Hematological Cancer Profiling System

ABSTRACT

A system for profiling lymphoma is provided that is based on the identification of sets of genes, which are characterized in that changes in expression of each gene within a set of genes can be correlated to one or more features of a specific lymphoma. The lymphoma profiling system provides for sets of “lymphoma profiling” genes and further provides for combinations of polynucleotide probes derived from one or more of the lymphoma profiling sets. These combinations of polynucleotide probes can be provided in solution or as an array. The combination of probes and the arrays can be used for disease prognosis, diagnosis, staging or grading, treatment management, monitoring of disease progression, predicting disease outcome or complications, and the like.

FIELD OF THE INVENTION

The present invention relates to the field of cancer diagnosis and profiling and, in particular, to tools for diagnosing and profiling hematological cancers.

BACKGROUND OF THE INVENTION

Hematological cancers are cancers of the blood and lymphatic system. These cancers usually affect the white blood cells (disease and infection-fighting cells) rather than the red blood cells (oxygen-carrying cells), and can occur in the marrow where all blood cells are made, or in the lymph nodes and other lymph tissues that the white blood cells flow through. Common hematological cancers are leukemia, lymphoma, and myeloma.

Lymphoma is a type of cancer affecting cells in the lymph system, and is most commonly caused by mutations in the genetic material of a B-cell or T-cell lymphocyte. Lymphocytes with these mutations lose their ability to control their own multiplication and are, therefore, able to overtake healthy tissue and form tumors. The type of mutation and the stage of development at which it occurs determine what class or type of lymphoma will arise. Since lymphocytes undergo several stages of hematopoietic differentiation during development from stem cell to mature B- or T-cell, many classes of lymphoma have been identified (Staudt L M. N Engl J Med. 2003; 348(18):1777-85. [Erratum: N Engl J Med. 2003; 348(25):2588.]) Correct identification of lymphoma types and/or sub-types is critical since different types of lymphomas have varied prognoses, and treatments for the various types may be entirely different (Soukup J, Krskova L, Mrhalova M, et al. Cas Lek Cesk. 2003; 142(7):417-2). Furthermore, recent studies have shown that within a single disease classification, the response to treatment between individuals can vary. For example, a group of patients were diagnosed with diffuse large cell B-cell lymphoma (DLBCL) by pathologists and treated. Some of these patients responded well to the treatment and were completely cured, but others did not and succumbed to the disease within a year (Alizadeh A A, Eisen M B, Davis R E et al. Nature. 2000; 403(6769):503-11).

In broadest terms, lymphomas can be classified as Hodgkin's disease or lymphoma (HD or HL) and non-Hodgkin's lymphoma (NHL). NHL can be further classified according to the type of lymphocyte affected, i.e. B-cell lymphomas or T-cell lymphomas.

The World Health Organization (WHO) has grouped non-Hodgkin's lymphomas into classes based on a combination of morphology, immunology, genetic features, and clinical features. According to this classification system, mature (peripheral) B-cell lymphomas have been classified into the following types: B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), B-cell prolymphocytic leukemia, lymphoplamacytic lymphoma, splenic marginal zone B-cell lymphoma, nodal marginal zone B-cell lymphoma, hairy cell leukemia, plasma cell myeloma/plasmacytoma, follicular lymphoma (FL), mantle cell lymphoma (MCL), Burkitt's lymphoma, and DLBCL. Hodgkin's lymphoma is also of B-cell origin.

DLBCL is an aggressive form of lymphoma that has a mortality rate of 50-60%. The WHO has sub-classified DLBCL into broad categories, thus making an accurate diagnosis difficult (Alizadeh A A, Eisen M B, Davis R E et al. Nature. 2000; 403(6769):503-11). More recently, however, molecular profiling of hundreds of DLBCL patient samples has resulted in the identification of the following sub-types of DLBCL based on gene expression patterns: a sub-type derived from differentiated activated peripheral blood B-cells (ABC), a second sub-type derived from the undifferentiated germinal centers of lymph nodes (GC), a third sub-type called mediastinal large B-cell lymphoma (MLBCL), and a fourth sub-type that remains largely heterogeneous (Rosenwald A, Wright G, Chan W C et al. N Engl J Med. 2002, 346(25):1937-47; Rosenwald A, Wright G, Leroy K. et al. J Exp Med. 2003, 198(6):851-62; Wright G, Tan B, Rosenwald A, et al. Proc Natl Acad Sci USA. 2003, 100(17):9991-6; Savage K J, Monti S, Kutok J L, et al. Blood. 2003, 102(12):3871-9).

T-cell lymphomas have been classified into the following types: lymphoblastic lymphoma, anaplastic large cell lymphoma (ALCL), subcutaneous T-cell lymphoma, mycosis fungoids/Sézary's syndrome, peripheral T-cell lymphomas, angioimmunoblastic lymphoma, angiocentric lymphoma (nasal T-cell lymphoma), intestinal T-cell lymphoma, and adult T-cell lymphoma/leukemia.

Despite efforts of the WHO and other organizations to classify lymphomas, these cancers are difficult to classify since there is no single marker that clinicians can consider to classify all of the various types of lymphoma (Harris N L, Jaffe E S, Diebold J et al. Ann Oncol. 2000; 11 Suppl 1:3-10). In most cases, physicians must employ a variety of techniques to clearly identify a patient's disease. These techniques include gross and microscopic morphological examination, detection of characteristic chromosomal rearrangements, and detection of aberrant gene expression. The complexity and subjectivity involved in interpreting the results obtained using these techniques add further challenges to clinicians and pathologists trying to diagnose and treat a patient with lymphoma.

Leukemia is a cancer of the white blood cells that starts in the bone marrow and spreads to the blood, lymph nodes, and other organs. Both children and adults can develop leukemia, which is a complex disease with many different types and sub-types. The treatment given and the outlook for patients with leukemia varies greatly according to the exact type and other individual factors. Leukemias are classified into types based on the kind of blood cell they involve, either lymphoid or myeloid, as well as the speed of disease progression, either acute or chronic. Acute lymphocytic leukemia (ALL) is the most common form of leukemia among children, often striking during infancy. Acute myelogenous leukemia (AML) occurs in both adults and children, while cases of chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML) are seen mainly in adults. Many leukemia subtypes exist within the various types. Subtypes are often defined by a specific mutation they share. Common subtypes include; MLL, T-ALL (T-cell acute lymphoblastic leukemia), BCR-ABL, TEL-AML1, E2A-PBX1, ALL with t(4;11). As for lymphoma, accurately distinguishing between the different types and subtypes of leukemia is critical for making correct diagnoses and for choosing the most beneficial treatment protocol. Current methods used to diagnose leukemia and distinguish types and subtypes of leukemia involve examination of a patient's medical history, a physical examination, complete blood counts, a bone marrow examination, cytogenetic studies, molecular diagnostics and immunophenotyping, followed by, in some cases assigning the patient to a specific risk group. This process can be difficult and expensive.

The advent of DNA array technology has allowed high-throughput analysis of gene expression in both lymphoma and leukemia. For example, “molecular profiling” of lymphomas has facilitated the identification of predictive factors or biomarkers that may potentially be used to characterize lymphomas. The “Lymphochip,” for example, has been used to identify sub-types of one specific type of lymphoma, DLBCL, and contains a total of 17,856 cDNA clones, the majority of which are derived from a germinal centre B-cell library, as well as cDNA clones derived from DLBCL, FL, MCL, and CLL libraries (Alizadeh A A, Eisen M B, Davis R E et al. Nature. 2000; 403(6769):503-11)). An oligonucleotide array has also been described, which was used to analyze the expression of 6,817 genes in diagnostic tumor specimens from DLBCL patients (Shipp M A, Ross K N, Tamayo P et al. Nat Med. 2002 January; 8(1):68-74). This array was used to predict outcome (cured vs. fatal) in this specific type of lymphoma and to identify potential therapeutic targets.

Other publications have described the use of oligonucleotide microarrays to accurately distinguish subtypes of leukemia. A commercially available microarray containing probes for 6817 genes was used to classify leukemia and identify a set of genes as class predictors (Golub T R, Slonim D K, Tamayo P, Huard C, Gaasenbeek M, Mesirov J P, Coller H, Loh M L, Downing J R, Caligiuri M A, Bloomfield C D and E S Lander. Science 1999 Oct. 15; 286(5439): 531-537). Others have used a commercially available microarray (Affymetrix U133A) to distinguish various subtypes of pediatric ALL with 96% accuracy (Ross M E, Zhou X, Song G, Shurtleff S A, Girtman K, Williams W K, Liu H C, Mahfouz R, Raimondi S C, Lenny N, Patel A and J R Downing. Blood 2003 Oct. 15; 102(8): 2951-2959).

In addition, U.S. Patent Application No. 20020110820 describes fourteen collections of 1000 genes, each representing a different cancer, including lymphoma and leukemia. Methods of using these collections to identify a tumor, predict the likelihood of tumor development, diagnose a tumor, or identify a compound for use in treating cancer are also described. The patent application further describes an oligonucleotide array containing a plurality of oligonucleotide probes specific for the genes in these collections.

U.S. Patent Application No. 20030175761 describes a group of 120 genes whose expression patterns allow differentiation between benign lymph node tissue, FL, MCL, and SLL. This patent application further describes nucleic acid arrays containing probes for these genes. U.S. Patent Application No. 20030219760 describes methods for diagnosing biological states or conditions based on ratios of gene expression data from tissue samples, such as cancer tissue samples. The application describes a method based on focused microarray-based profiling that permits confirmation of the presence of malignant pleural mesothelioma. The application also indicates that the method is applicable to a variety of other cancers, including lymphomas and leukemias, and lists sets of genes that were selected based on analysis of gene expression data presented in the prior art. The listed genes include genes that are differentially expressed in different sub-types of DLBCL, that are over-expressed in DLBCL and FL, and that are over-expressed in DLBCL of good and poor outcome.

U.S. Patent Application No. 20040018513 describes methods and compositions useful for diagnosing and choosing treatment for leukemia patients. These methods are based on analysis of gene expression using HG_U95Av2 Affymetrix™ oligonucleotide arrays, and relate to patients that can be assigned to a leukemia risk group selected from T-ALL, E2A-PBX1, TEL-AML1, BCR-ABL, MLL, Hyperdiploid >50, and a risk group called “Novel,” which is distinguishable from the others in the list based on expression profiling. The methods can be used to assign a subject affected by leukemia to a leukemia risk group, predict increased risk of relapse, predict increased risk of developing secondary acute myeloid leukemia, determine prognosis, choose therapy, and monitor disease state. The application also describes arrays having capture probes for the differentially-expressed genes described therein.

This background information is provided for the purpose of making known information believed by the applicant to be of possible relevance to the present invention. No admission is necessarily intended, nor should be construed, that any of the preceding information constitutes prior art against the present invention.

SUMMARY OF THE INVENTION

An object of the present invention is to provide a hematological cancer profiling system. In accordance with one aspect of the present invention, there is provided a system for profiling a hematological cancer comprising at least ten polynucleotide probes, each of said probes being between about 15 and about 500 nucleotides in length and comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene selected from the group of genes set forth in Table 1, wherein the level of expression of said gene is indicative of one or more features of said hematological cancer.

In accordance with another aspect of the present invention, there is provided a use of the system according to the present invention for the preparation of a nucleic acid array.

In accordance with another aspect of the present invention, there is provided a method of profiling a hematological cancer in a subject comprising: (a) providing one or more gene sets, each gene set comprising at least five genes selected from the genes set forth in Table 1, wherein the expression level of each gene in said one or more gene sets is indicative of a feature of a heinatological cancer; (b) determining the expression level of each gene in said one or more gene sets in a test sample obtained from said subject to provide an expression pattern profile, and (c) comparing said expression pattern profile with a reference expression pattern profile.

In accordance with another aspect of the present invention, there is provided a nucleic acid array comprising at least ten polynucleotide probes immobilized on a solid support, each of said probes being between about 15 and about 500 nucleotides in length and comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene selected from the group of genes set forth in Table 1, wherein the level of expression of said gene is indicative of one or more features of said hematological cancer.

In accordance with another aspect of the present invention, there is provided a polynucleotide probe between about 15 and about 500 nucleotides in length and comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene selected from the group of genes set forth in Table 1, wherein said probe comprises at least 15 consecutive nucleotides of a sequence as set forth in any one of SEQ ID NOs: 1-4530.

In accordance with another aspect of the present invention, there is provided a set of genes having an expression pattern representative of one or more features of a hematological cancer and comprising at least ten genes selected from: (a) at least ten genes selected from the genes set forth in Table 32; (b) at least ten genes selected from the genes set forth in Table 33; (c) at least ten genes selected from the genes set forth in Table 34; (d) at least ten genes selected from the genes set forth in Table 35; (e) at least ten genes selected from the genes set forth in Table 36; (f) at least ten genes selected from the genes set forth in Table 37; (g) at least ten genes selected from the genes set forth in Table 38; (h) at least ten genes selected from the genes set forth in Table 39; (i) at least ten genes selected from the genes set forth in Table 40, and (j) at least ten genes selected from the genes set forth in Table 41.

In accordance with another aspect of the present invention, there is provided a library of genes for profiling a hematological cancer, comprising the genes as set forth in Table 1.

In accordance with another aspect of the present invention, there is provided a computer-readable medium comprising one or more digitally-encoded expression pattern profiles representative of a set of genes according to any one of claims 38-41, each of said one or more expression pattern profiles being associated with one or more values wherein each of said one or more values is correlated with one of said one or more features of a hematological cancer.

BRIEF DESCRIPTION OF FIGURES

FIG. 1 depicts a hierarchical clustering image of DLBCL signature genes in DLBCL samples versus control.

FIG. 2 depicts a hierarchical clustering image of FL signature genes in FL samples versus control.

FIG. 3 depicts a hierarchical clustering image of HL signature genes in HL samples versus control.

FIG. 4 depicts a hierarchical clustering image of MCL signature genes in MCL samples versus control.

FIG. 5 depicts a hierarchical clustering image of MZL signature genes in MZL samples versus control.

FIG. 6 depicts a hierarchical clustering image of SLL signature genes in SLL samples versus control.

FIG. 7 depicts a hierarchical clustering image of TCL signature genes in TCL samples versus control.

FIG. 8 depicts a hierarchical clustering image of lymphoma signature genes in 23 lymphoma samples versus control.

FIG. 9 depicts a hierarchical clustering image of leukemia signature genes in 4 leukemia samples versus control, and in 3 lymphoma samples.

FIG. 10 depicts a hierarchical clustering image of CLL signature genes in CLL samples versus control.

FIG. 11 depicts a hierarchical clustering image of AML signature genes in AML samples versus control.

FIG. 12 depicts a hierarchical clustering image of T-ALL signature genes in T-All samples versus control.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides for a system for profiling hematological cancers. This system is based on the identification of a pool, or library, of genes that are characterized in that changes in expression of each of the genes can be correlated to one or more features of a hematological cancer. The library provided by the present invention can be used as a resource from which sets of “hematological cancer profiling” genes can be selected, each set representing a specific hematological cancer, for example, lymphoma or leukemia, or a type or sub-type of lymphoma or leukemia. The level of expression of each gene in a hematological cancer profiling set is indicative of one or more features of the hematological cancer represented by that set of genes. A combination of polynucleotide probes (a “hematological cancer profiling combination”) that comprises probes derived from the sequences of the genes of one or more hematological cancer profiling sets can then be prepared in order to profile one or more hematological cancers of interest. The system of the present invention thus provides the user with the flexibility of assessing the type(s) and/or feature(s) of the hematological cancer(s) that are of specific interest by selecting an appropriate hematological cancer profiling combination. In accordance with the present invention, the hematological cancer is selected from the group of: lymphoma and leukemia. Non-limiting examples of features of these cancers that can be assessed with system of the present invention include presence/absence, type, subtype, stage, progression, grade, aggressivity, outcome, survival and drug-responsiveness of hematological cancers, and the like.

The system of the present invention thus provides for sets of “hematological cancer profiling” genes selected from the library of genes. The system further provides for combinations of polynucleotide probes (“hematological cancer profiling combinations”) derived from the sequences of the genes of one or more hematological cancer profiling sets. A hematological cancer profiling combination thus comprises a plurality of probes that represent one or more hematological cancer profiling sets.

As indicated above, the system of the present invention allows for hematological cancer profiling combinations to be selected that are tailored to assess type(s) and/or feature(s) of the hematological cancer(s) of interest. The combination of probes thus may be tailored as desired such that it represents a single feature of a hematological cancer, multiple features of a hematological cancer, a single feature of multiple hematological cancers or multiple features of multiple hematological cancers.

The system provides for combinations of probes in solution, for example, for use in standard solution hybridization techniques or for use in quantitative PCR applications, as well as combinations of probes in an immobilised format, for example, as an array. The system can be used to analyse the expression pattern of genes belonging to one or more hematological cancer profiling (HCP) sets in a blood or biopsy sample from a patient having, suspected of having, or suspected of being at risk of developing, a hematological cancer. The resulting information allows the determination of one or more features of the hematological cancer such as those described above, and is, therefore, useful in disease prognosis, diagnosis, staging or grading, treatment management, monitoring of disease progression, predicting disease outcome or complications, and the like. The system can thus be used to profile a hematological cancer selected from the group of lymphoma and leukemia.

DEFINITIONS

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

As used herein, the term “about” refers to a +/−10% variation from the nominal value. It is to be understood that such a variation is always included in any given value provided herein, whether or not it is specifically referred to.

The term “feature of a hematological cancer,” as used herein, refers to a characteristic of a hematological cancer. Such characteristics include fundamental aspects such as presence/absence of the disease in a subject and type of hematological cancer that are useful in diagnosis, as well as characteristics such as subtype, stage, progression, grade, aggressivity, drug-responsiveness, and the like, which are useful for disease management and patient care.

The term “gene,” as used herein, refers to a segment of nucleic acid that encodes an individual protein or RNA (also referred to as a “coding sequence” or “coding region”) together with associated regulatory regions such as promoters, operators, terminators and the like, that may be located upstream or downstream of the coding sequence.

The term “target gene,” as used herein, refers to a gene, the expression of which is to be detected using a polynucleotide probe of a hematological cancer profiling combination. In the context of the present invention, the target gene is a member of a hematological cancer profiling set.

The term “target mRNA,” as used herein, refers to an mRNA transcribed from a target gene.

The terms “oligonucleotide” and “polynucleotide” as used interchangeably in the present application refer to a polymer of greater than one nucleotide in length of ribonucleic acid (RNA), deoxyribonucleic acid (DNA), hybrid RNA/DNA, modified RNA or DNA, or RNA or DNA mimetics. The polynucleotides may be single- or double-stranded. The terms include polynucleotides composed of naturally-occurring nucleobases, sugars and covalent internucleoside (backbone) linkages as well as polynucleotides having non-naturally-occurring portions which function similarly. Such modified or substituted polynucleotides are well-known in the art and for the purposes of the present invention, are referred to as “analogues.”

The terms “probe” and “polynucleotide probe,” as used herein, refer to a polynucleotide that is capable of hybridizing to a target gene or target mRNA and includes polynucleotides in solution as well as those that are immobilized to a solid substrate, e.g. in an array.

By “gene expression pattern” or “expression pattern” is meant the level of gene expression of one or more target genes in a test sample, for example, genes of a hematological cancer profiling set as assessed by methods described herein. The “level of gene expression” refers to an absolute or relative amount of the transcription product of the target gene(s). Typically, the level of expression is measured relative to a reference sample and can be increased (up-regulated), decreased (down-regulated) or unchanged relative to the reference sample. The gene expression pattern can be measured at a single time point or over a period of time.

By “altered gene expression” is meant an increase or decrease in gene expression, as described below.

By “decrease in gene expression” is meant a lowering of the level of expression of a gene relative to a reference sample. Typically, the decrease is at least 10% relative to the reference. In one embodiment, a decrease in gene expression refers to a decrease in expression of the gene by at least 25%. In other embodiments, a decrease in gene expression refers to a decrease in expression of the gene by at least 30%, 40%, 50%, 60%, 70%, 80%, and 90%. Alternatively, a decrease in gene expression is at least 2-fold relative to the reference. In further embodiments, a decrease in gene expression refers to a decrease in expression of the gene by at least 3, 5, 7, or 10-fold relative to the reference.

By “increase in gene expression” is meant a raising of the level of expression of a gene relative to a reference sample. Typically, the increase is at least 10% relative to the reference. In one embodiment, an increase in gene expression refers to a decrease in expression of the gene by at least 25%. In other embodiments, an increase in gene expression refers to an increase in expression of the gene by at least 30%, 40%, 50%, 60%, 70%, 80%, and 90%. Alternatively, an increase in gene expression is at least 2-fold relative to the reference. In further embodiments, an increase in gene expression refers to an increase in expression of the gene by at least 3, 5, 7, or 10-fold relative to the reference.

The term “selectively hybridize,” as used herein, refers to the ability of a polynucleotide probe bind detectably and specifically to a target gene or nucleic acids derived therefrom. A polynucleotide probe selectively hybridizes to a target gene or nucleic acids under hybridization and wash conditions that minimize appreciable amounts of detectable binding to non-specific nucleic acids. High stringency conditions can be used to achieve selective hybridization conditions as known in the art and discussed herein. Typically, hybridization and washing conditions are performed at high stringency according to conventional hybridization procedures. Washing conditions are typically 1-3×SSC, 0.1-1% SDS, 50-70° C. with a change of wash solution after about 5-30 minutes.

The terms “corresponding to” or “corresponds to” indicates that a polynucleotide sequence is identical to all or a portion of a reference polynucleotide sequence. In contradistinction, the term “complementary to” is used herein to indicate that the polynucleotide sequence is identical to all or a portion of the complementary strand of a reference polynucleotide sequence. For illustration, the nucleotide sequence “TATAC” corresponds to a reference sequence “TATAC” and is complementary to a reference sequence “GTATA.”

The following terms are used herein to describe the sequence relationships between two or more polynucleotides: “reference sequence,” “window of comparison,” “sequence identity,” and “percent sequence identity.” A “reference sequence” is a defined sequence used as a basis for a sequence comparison; a reference sequence may be a subset of a larger sequence, for example, as a segment of a full-length cDNA, or gene sequence, or may comprise a complete cDNA, or gene sequence. Generally, a reference polynucleotide sequence is at least 20 nucleotides in length, and often at least 50 nucleotides in length.

A “window of comparison”, as used herein, refers to a conceptual segment of the reference sequence of at least 15 contiguous nucleotide positions over which a candidate sequence may be compared to the reference sequence and wherein the portion of the candidate sequence in the window of comparison may comprise additions or deletions (i.e. gaps) of 20 percent or less as compared to the reference sequence (which does not comprise additions or deletions) for optimal alignment of the two sequences. The present invention contemplates various lengths for the window of comparison, up to and including the full length of either the reference or candidate sequence. Optimal alignment of sequences for aligning a comparison window may be conducted using the local homology algorithm of Smith and Waterman (Adv. Appl. Math. (1981) 2:482), the homology alignment algorithm of Needleman and Wunsch (J. Mol. Biol. (1970) 48:443), the search for similarity method of Pearson and Lipman (Proc. Natl. Acad. Sci. (U.S.A.) (1988) 85:2444), using computerized implementations of these algorithms (such as GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package Release 7.0, Genetics Computer Group, 573 Science Dr., Madison, Wis.), using publicly available computer software such as ALIGN or Megalign (DNASTAR), or by inspection. The best alignment (i.e. resulting in the highest percentage of identity over the comparison window) is then selected.

The term “sequence identity” means that two polynucleotide sequences are identical (i.e. on a nucleotide-by-nucleotide basis) over the window of comparison.

The term “percent (%) sequence identity,” as used herein with respect to a reference sequence is defined as the percentage of nucleotides in a candidate sequence that are identical with the nucleotides in the reference polynucleotide sequence over the window of comparison after optimal alignment of the sequences and introducing gaps, if necessary, to achieve the maximum percent sequence identity.

1. Hematological Cancer Profiling System

The system of the present invention is based on the identification of genes whose expression level is altered in a subject having a hematological cancer when compared to a reference subject and thus are indicative of a feature of the hematological cancer. For example, if the hematological cancer is lymphoma or leukemia, then depending on the feature in question, the reference subject can be, for example, a disease-free subject, a subject having a different type or subtype of lymphoma or leukemia, a subject undergoing a different therapeutic regimen, a subject with a different stage or grade of lymphoma or leukemia, a subject with an indolent form of disease, etc. Such genes are candidates for inclusion in one or more of the hematological cancer profiling (HCP) sets of the invention. Once genes have been selected for the HCP set(s), probes can be designed that specifically hybridise to the genes within the set. Combinations of the probes can then be formed that comprise probes representing those HCP sets that correlate with the hematological cancer(s) and/or feature(s) of the hematological cancer(s) that are of interest.

1.1 Hematological Cancer Profiling (HCP) Sets

An HCP set comprises one or more genes related to a hematological cancer, such as lymphoma or leukemia, i.e. a gene whose expression pattern is indicative of a selected lymphoma or leukemia, or a feature of a selected lymphoma or leukemia. For example, the level of expression of the gene can be indicative of the presence of a particular lymphoma or subtype thereof; the stage, grade, or aggressivity of a lymphoma or subtype thereof; the progression of a lymphoma or subtype thereof (for example, whether the lymphoma is localized, regional, or metastatic); the drug-responsiveness of a lymphoma or subtype thereof (for example, whether the lymphoma is drug-sensitive, drug-resistant or multi-drug resistant); the likelihood of transformation of one type of lymphoma to another (for example, transformation of FL into DLBCL); whether the lymphoma is refractory (i.e. not responsive to treatment); likelihood for the lymphoma to be fatal; mutational status of a lymphoma, and the like. Alternatively, the level of expression of the gene in an HCP set may reflect whether a subject affected by leukemia has a particular sub-type of leukemia, an increased risk of relapse, has an increased risk of developing secondary acute myeloid leukemia, prognosis for the subject with leukemia, selection of appropriate therapy for leukemia, the drug-responsiveness of leukemia or sub-type thereof, or the progression of the leukemia.

As is known in the art, some genes have been identified that correlate with more than one hematological cancer. For example, the expression level of a gene may be indicative of a feature of both lymphoma and leukemia. Moreover, some genes have been identified that correlate with more than one feature of a specific hematological cancer. For example, the expression level of a gene may be correlated to transformation of one type of lymphoma to another as well as being indicative of the subtype of that lymphoma. Such genes are also suitable for inclusion in the HCP sets of the present invention.

Each gene selected for inclusion in a particular HCP set relates to the same hematological cancer or type, or sub-type of a hematological cancer. As indicated above, hematological cancers contemplated by the present invention are selected from lymphoma or leukemia. Thus, for example, all of the genes of an HCP set may relate to lymphoma in general. Alternatively, exemplary types of lymphomas for which an HCP set can be formed include, but are not limited to, small lymphocytic lymphoma (SLL), B-cell prolymphocytic leukemia, lymphoplamacytic lymphoma, splenic marginal zone B-cell lymphoma, nodal marginal zone B-cell lymphoma, hairy cell leukemia, plasma cell myeloma/plasmacytoma, follicular lymphoma (FL), mantle cell lymphoma (MCL), Burkitt's lymphoma, diffuse large cell B-cell lymphoma (DLBCL), Hodgkin's lymphoma, lymphoblastic lymphoma, anaplastic large cell lymphoma (ALCL), cutaneous T-cell lymphoma, mycosis fungoids/Sézary's syndrome, peripheral T-cell lymphomas, angioimmunoblastic lymphoma, angiocentric lymphoma (nasal T-cell lymphoma), intestinal T-cell lymphoma, and adult T-cell lymphoma/leukemia. In one embodiment of the invention, genes selected for inclusion in an HCP set relate to a type of lymphoma selected from the group of: DLBCL, FL, CLL/SLL, MCL, HL, and ALCL.

Likewise, the present invention further contemplates that all of the genes of an HCP set may relate to leukemia in general. Alternatively, all of the genes of an HCP set may relate to a sub-type of leukemia. Exemplary sub-types of leukemias for which an HCP set can be designed include, but are not limited to B-cell chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute lymphocytic leukemia (ALL), acute myelogenous leukemia (AML), T-ALL, MLL, BCR-ABL, TEL-AML1, E2A-PBX1, ALL with t(4;11). In one embodiment of the invention, genes selected for inclusion in an HCP set relate to a leukemia selected from the group of CLL, AML, and T-ALL.

With respect to CLL, a worker skilled in the art would understand that this sub-type of hematological cancer may be considered as a sub-type of lymphoma. Alternatively, it may be considered as a sub-type of leukemia.

Appropriate candidate genes for inclusion in the HCP sets can be selected from genes known in the art to be markers for a particular feature of a hematological cancer. Such genes can be identified from publicly available databases using a variety of “data mining” approaches known in the art. Alternatively, candidate genes can be identified by screening a nucleic acid library derived from a hematological cancer exhibiting a specific feature and selecting for genes whose expression level is modulated in this library when compared to a reference nucleic acid library. Methods of creating nucleic acid libraries are well known in the art (see, for example, Ausubel et al., (1997 & updates) Current Protocols in Molecular Biology, Wiley & Sons, New York).

In one embodiment of the present invention, candidate genes for inclusion in the HCP sets are identified by data mining. As is known in the art, publication and sequence databases can be mined using a variety of search strategies. For example, currently available scientific and medical publication databases such as Medline, Current Contents, OMIM (online Mendelian inheritance in man), various Biological and Chemical Abstracts, Journal indexes, and the like can be searched using term or key-word searches, or by author, title, or other relevant search parameters. Many such databases are publicly available, and strategies and procedures for identifying publications and their contents, for example, genes, other nucleotide sequences, descriptions, indications, expression pattern, etc, are well known to those skilled in the art. Numerous databases are available through the internet for free or by subscription, see, for example, the National Center Biotechnology Information (NCBI), Infotrieve, Thomson ISI, and Science Magazine (published by the AAAS) websites. Additional or alternative publication or citation databases are also available that provide identical or similar types of information, any of which can be employed in the context of the invention. These databases can be searched for publications describing altered gene expression between features of hematological cancers such as types of hematological cancers, for example types of lymphoma or leukemia, or subtypes of a specific hematological cancer, such as subtypes of lymphoma or leukemia.

For example, genes can initially be selected by consulting publications to identify genes that have been shown to be indicative of features of hematological cancers. The methods used to determine the expression level of these genes can include a variety of methods including PCR, Northern blots and microarray studies. Points can be awarded to potential candidate genes based on the number of independent researchers finding modulations within the hematological cancer as well as the number of different methods used to determine the expression level of these genes in the hematological cancer. The genes can then be ranked according to the number of points awarded, and those with the highest number of points may be selected as candidate genes. The number of candidate genes selected can vary depending on the number of features to be analyzed.

Gene sequences for genes of interest can be obtained from a variety of publicly available and proprietary sequence databases (including Genbank, dbEST, UniGene, and TIGR and SAGE databases) including sequences corresponding to expressed nucleotide sequences, such as expressed sequence tags (ESTs). For example, the Genbank™ website located at the NCBI website among others, can be readily accessed and searched via the internet. These and other sequence and clone database resources are currently available; however, a number of additional or alternative databases comprising gene sequences, EST sequences, clone repositories, PCR primer sequences, and the like corresponding to individual nucleotide sequences are also known and are suitable for the purposes of the invention.

While the above discussion relates primarily to “genomics” approaches, one skilled in the art will understand that numerous, analogous “proteomics” approaches are also suitable for selection of candidate genes for the HCP sets. For example, a differentially expressed protein product can, for example, be identified using Western analysis, two-dimensional gel analysis, chromatographic separation, mass spectrometric detection, protein-fusion reporter constructs, colorimetric assays, binding to a protein array, or by characterization of polysomal mRNA. The protein is further characterized and the nucleotide sequence encoding the protein is identified using standard techniques, e.g. by screening a cDNA library using a probe based on protein sequence information. Genes identified in this manner can also be included in the HCP set.

Representative, non-limiting examples of candidate genes for inclusion in HCP sets in accordance with the present invention are shown in Table 1.

TABLE 1 Candidate genes whose expression pattern is indicative of one or more feature of a hematological cancer selected from the group of lymphoma and leukemia GenBank Accession Symbol AA594161 MYH11 AA766908 MME AB014540 SWAP70 AF196185 PARD3 AI597616 MRPL33 AI634809 ARID5B AI672553 AKAP12 AI809213 RGS13 AK022231 STAT1 AK022293 CTSD AK055652 C3orf6 AL080130 FLJ14001 AL833316 MIR AW291384 STS-1 BE897089 ZNF91 BG993697 SMYD3 BI769730 HLA-DRB1 BQ632574 RASA1 BX504817 SFRS7 H53164 IRF8 H57732 TGFBR2 L29376 3.8-1 M80899 AHNAK NM_000038 APC NM_000043 FAS NM_000061 BTK NM_000075 CDK4 NM_000109 DMD NM_000189 HK2 NM_000237 LPL NM_000269 NME1 NM_000271 NPC1 NM_000295 SERPINA1 NM_000313 PROS1 NM_000397 CYBB NM_000405 GM2A NM_000424 KRT5 NM_000483 APOC2 NM_000576 IL1B NM_000579 CCR5 NM_000584 IL8 NM_000585 IL15 NM_000600 IL6 NM_000626 CD79B NM_000627 LTBP1 NM_000633 BCL2 NM_000655 SELL NM_000713 BLVRB NM_000785 CYP27B1 NM_000788 DCK NM_000853 GSTT1 NM_000877 IL1R1 NM_000917 P4HA1 NM_000927 ABCB1 NM_001067 TOP2A NM_001068 TOP2B NM_001110 ADAM10 NM_001154 ANXA5 NM_001166 BIRC2 NM_001196 BID NM_001230 CASP10 NM_001238 CCNE1 NM_001242 TNFRSF7 NM_001254 CDC6 NM_001350 DAXX NM_001425 EMP3 NM_001552 IGFBP4 NM_001558 IL10RA NM_001618 PARP1 NM_001621 AHR NM_001647 APOD NM_001663 ARF6 NM_001706 BCL6 NM_001760 CCND3 NM_001762 CCT6A NM_001770 CD19 NM_001771 CD22 NM_001779 CD58 NM_001781 CD69 NM_001782 CD72 NM_001826 CKS1B NM_001827 CKS2 NM_001831 CLU NM_001852 COL9A2 NM_001853 COL9A3 NM_001877 CR2 NM_001888 CRYM NM_001894 CSNK1E NM_001951 E2F5 NM_001967 EIF4A2 NM_002002 FCER2 NM_002051 GATA3 NM_002095 GTF2E2 NM_002101 GYPC NM_002105 H2AFX NM_002120 HLA-DOB NM_002122 HLA-DQA1 NM_002155 HSPA6 NM_002189 IL15RA NM_002211 ITGB1 NM_002217 ITIH3 NM_002250 KCNN4 NM_002305 LGALS1 NM_002350 LYN NM_002358 MAD2L1 NM_002426 MMP12 NM_002467 MYC NM_002526 NT5E NM_002567 PBP NM_002646 PIK3C2B NM_002661 PLCG2 NM_002692 POLE2 NM_002738 PRKCB1 NM_002752 MAPK9 NM_002832 PTPN7 NM_002838 PTPRC NM_002891 RASGRF1 NM_002892 ARID4A NM_002943 RORA NM_002966 S100A10 NM_002967 SAFB NM_003037 SLAMF1 NM_003088 FSCN1 NM_003177 SYK NM_003217 TEGT NM_003226 TFF3 NM_003243 TGFBR3 NM_003254 TIMP1 NM_003290 TPM4 NM_003299 TRA1 NM_003332 TYROBP NM_003362 UNG NM_003451 ZNF177 NM_003648 DGKD NM_003656 CAMK1 NM_003810 TNFSF10 NM_003875 GMPS NM_003959 HIP1R NM_004049 BCL2A1 NM_004073 PLK3 NM_004091 E2F2 NM_004117 FKBP5 NM_004126 GNG11 NM_004184 WARS NM_004271 LY86 NM_004289 NFE2L3 NM_004322 BAD NM_004354 CCNG2 NM_004356 CD81 NM_004358 CDC25B NM_004422 DVL2 NM_004445 EPHB6 NM_004510 SP110 NM_004529 MLLT3 NM_004556 NFKBIE NM_004577 PSPH NM_004619 TRAF5 NM_004635 MAPKAPK3 NM_004737 LARGE NM_004844 SH3BP5 NM_004851 NAPSA NM_004951 EBI2 NM_005013 NUCB2 NM_005077 TLE1 NM_005127 CLECSF2 NM_005211 CSF1R NM_005213 CSTA NM_005214 CTLA4 NM_005271 GLUD1 NM_005292 GPR18 NM_005347 HSPA5 NM_005348 HSPCA NM_005415 SLC20A1 NM_005449 TOSO NM_005461 MAFB NM_005531 IFI16 NM_005582 LY64 NM_005601 NKG7 NM_005606 LGMN NM_005610 RBBP4 NM_005623 CCL8 NM_005638 SYBL1 NM_005652 TERF2 NM_005658 TRAF1 NM_005856 RAMP3 NM_005935 MLLT2 NM_005950 MT1G NM_005951 MT1H NM_006006 ZBTB16 NM_006014 DXS9879E NM_006115 PRAME NM_006162 NFATC1 NM_006164 NFE2L2 NM_006195 PBX3 NM_006218 PIK3CA NM_006254 PRKCD NM_006257 PRKCQ NM_006274 CCL19 NM_006317 BASP1 NM_006332 IFI30 NM_006475 POSTN NM_006498 LGALS2 NM_006558 KHDRBS3 NM_006620 HBS1L NM_006644 HSPH1 NM_006734 HIVEP2 NM_006761 YWHAE NM_006763 BTG2 NM_006841 SLC38A3 NM_006889 CD86 NM_006892 DNMT3B NM_006986 MAGED1 NM_007311 BZRP NM_007360 KLRK1 NM_007361 NID2 NM_012203 GRHPR NM_012448 STAT5B NM_012452 TNFRSF13B NM_013230 CD24 NM_014246 CELSR1 NM_014257 CD209L NM_014338 PISD NM_014456 PDCD4 NM_014686 KIAA0355 NM_014762 DHCR24 NM_015187 KIAA0746 NM_015641 TES NM_015866 PRDM2 NM_016076 PNAS-4 NM_016081 KIAA0992 NM_016187 BIN2 NM_016336 UBE2J1 NM_016628 WAC NM_017530 LOC55565 NM_017784 OSBPL10 NM_017935 BANK1 NM_017955 CDCA4 NM_018442 IQWD1 NM_018842 BAIAP2L1 NM_020151 STARD7 NM_020199 C5orf15 NM_020529 NFKBIA NM_020992 PDLIM1 NM_021813 BACH2 NM_021822 APOBEC3G NM_021950 MS4A1 NM_021966 TCL1A NM_022552 DNMT3A NM_023037 13CDNA73 NM_024708 ASB7 NM_025113 C13orf18 NM_025216 WNT10A NM_030666 SERPINB1 NM_030764 SPAP1 NM_030775 WNT5B NM_031305 ARHGAP24 NM_031942 CDCA7 NM_032991 CASP3 NM_033208 TIGD7 NM_033274 ADAM19 NM_057735 CCNE2 NM_078467 CDKN1A NM_079421 CDKN2D NM_080593 HIST1H2BK NM_138340 ABHD3 NM_138379 TIMD4 NM_139207 NAP1L1 NM_139276 STAT3 NM_144646 IGJ NM_145804 ABTB2 NM_152785 GCET2 NM_172373 ELF1 NM_173624 FLJ40504 NM_175870 LOC90925 NM_177968 PPM1B NM_181443 BTBD3 NM_181838 UBE2D2 NM_182746 MCM4 NM_182776 MCM7 NM_198833 SERPINB8 NM_201593 CACNB2 R99527 MGC39372 T66903 LOC54103 U37028 ITGAD W56129 SFRS9 X58529 IGHM AA188785 LOC286025 AA347638 BCR AA601122 SECTM1 AA642467 SLC2A14 AA682722 LARP AA757235 LOC399933 AA765313 FZD3 AB002310 HUWE1 AB002333 ZNF518 AB024402 ING1 AB028952 SYNPO AB032991 NDFIP2 AF008915 EVI5 AF108138 C15orf20 AF116668 LMO2 AF143327 FLJ32810 AF200348 D2S448 AF245480 MONDOA AI075159 SPTA1 BU948323 TCF4 AI523104 LILRB1 AI675029 C7 AI694012 PSMA5 AI732248 COL4A1 AJ007509 HNRPUL1 AK022224 ACTN1 AK023928 PSCD1 AK024580 NRP1 AK025005 MARCH1 AK091853 COL3A1 AK126650 CAPZB AK127124 ARHGEF4 AK127132 DRG1 AK129940 GNAI1 AL049313 CLIC5 AL049327 CBLB AL049449 GAB1 AL050391 CASP4 AL137527 LRCH3 AL353942 SEPT11 AL833915 TDRD9 AL834278 USP30 AU252485 MAP7 AV650179 PRG1 AV686223 KIAA1407 AW014009 MAP2K3 AW190768 SLC13A3 AW292143 GFAP AW439398 CCND1 AW452039 HRMT1L3 AW615076 LOC492304 AW664012 ALOX5 AW967479 CD38 AW970654 PHTF2 BC028066 NALP1 BC034289 LOC87769 BC042366 PCDH9 BC045532 LSM8 BC050383 TMPO BC050602 HIST1H2AC BC058855 VEGF BE147267 ECE1 BE549606 BZW1 BE798965 LAMC1 BE927772 SFRS3 BF055235 RIPK1 BF513638 WNT3 BF848289 CSDA BG682263 HDAC3 BG683220 PMS2 BG747999 MT1L BI493513 PHF8 BI559738 GPR56 BM709325 BCL7A BM711190 MED28 BM727177 GOLT1B BQ009245 GPM6B BQ021469 AGPS BQ215285 LEF1 BQ898221 ITGA6 BU929213 SESN3 BU954396 RPL11 BX095432 CNTN5 BX640908 EVI1 BX648339 USP53 BX648365 SEPT7 BX649193 TKT C05886 ETV6 D31762 TRAM2 D86967 EDEM1 H41942 NPEPPS M60028 HLA-DQB1 M77810 GATA2 N26272 MSI2 N28431 COL6A1 N41620 WWP1 N53163 COL27A1 N54946 EWSR1 N70000 UBE3B NM_000016 ACADM NM_000022 ADA NM_000024 ADRB2 NM_000033 ABCD1 NM_000062 SERPING1 NM_000089 COL1A2 NM_000099 CST3 NM_000110 DPYD NM_000118 ENG NM_000120 EPHX1 NM_000147 FUCA1 NM_000169 GLA NM_000182 HADHA NM_000194 HPRT1 NM_000214 JAG1 NM_000234 LIG1 NM_000239 LYZ NM_000246 MHC2TA NM_000249 MLH1 NM_000251 MSH2 NM_000277 PAH NM_000305 PON2 NM_000314 PTEN NM_000341 SLC3A1 NM_000361 THBD NM_000382 ALDH3A2 NM_000395 CSF2RB NM_000417 IL2RA NM_000418 IL4R NM_000435 NOTCH3 NM_000448 RAG1 NM_000484 APP NM_000485 APRT NM_000536 RAG2 NM_000545 TCF1 NM_000546 TP53 NM_000561 GSTM1 NM_000574 DAF NM_000578 SLC11A1 NM_000594 TNF NM_000598 IGFBP3 NM_000601 HGF NM_000604 FGFR1 NM_000610 CD44 NM_000628 IL10RB NM_000629 IFNAR1 NM_000640 IL13RA2 NM_000660 TGFB1 NM_000700 ANXA1 NM_000701 ATP1A1 NM_000717 CA4 NM_00729 CCK NM_000732 CD3D NM_000773 CYP2E1 NM_000778 CYP4N11 NM_000791 DHFR NM_000801 FKBP1A NM_000852 GSTP1 NM_000856 GUCY1A3 NM_000867 HTR2B NM_000878 IL2RB NM_000885 ITGA4 NM_000887 ITGAX NM_000905 NPY NM_000906 NPR1 NM_000953 PTGDR NM_000960 PTGDR NM_000964 RARA NM_000967 RPL3 NM_000968 RPL4 NM_000969 RPL5 NM_000970 RPL6 NM_000972 RPL7A NM_001001 CD36 547 NM_001005 RPS3 NM_001009 RPS5 NM_001015 RPS11 NM_001019 RPS15A NM_001069 TUBB2 NM_001079 ZAP70 NM_001092 ABR NM_001130 AES NM_001150 ANPEP NM_001165 BIRC3 NM_001175 ARHGDIB NM_001178 ARNTL NM_001207 BTF3 NM_001211 BUB1B NM_001219 CALU NM_001226 CASP6 NM_001228 CASP8 NM_001229 CASP9 NM_001237 CCNA2 NM_001239 CCNH NM_001255 CDC20 NM_001256 CDC27 NM_001265 CDX2 NM_001266 CES1 NM_001273 CHD4 NM_001274 CHEK1 NM_001280 CIRBP NM_001295 CCR1 NM_001312 CRIP2 NM_001313 CRMP1 NM_001337 CX3CR1 NM_001344 DAD1 NM_001345 DGKA NM_001398 ECH1 NM_001404 EEF1G NM_001428 ENO1 NM_001436 FBL NM_001441 FAAH NM_001456 FLNA NM_001459 FLT3LG NM_001462 FPRL1 NM_001489 NR6A1 NM_001513 GSTZ1 NM_001515 GTF2H2 NM_001540 HSPB1 NM_001560 IL13RA1 NM_001607 ACAA1 NM_001630 ANXA8 NM_001640 APEH NM_001654 ARAF NM_001664 RHOA NM_001700 AZU1 NM_001712 CEACAM1 NM_001715 BLK NM_001716 BLR1 NM_001728 BSG NM_001734 C1S NM_001743 CALM2 NM_001747 CAPG NM_001752 CAT NM_001753 CAV1 NM_001759 CCND2 NM_001767 CD2 NM_001772 CD33 NM_001774 CD37 NM_001776 ENTPD1 NM_001783 CD79A NM_001786 CDC2 NM_001793 CDH3 NM_001794 CDH4 NM_001795 CDH5 NM_001798 CDK2 NM_001830 CLCN4 NM_001838 CCR7 NM_001839 CNN3 NM_001897 CSPG4 NM_001901 CTGF NM_001905 CTPS NM_001908 CTSB NM_001916 CYC1 NM_001923 DDB1 NM_001928 DF NM_001939 DRP2 NM_001941 DSC3 NM_001952 E2F6 NM_001964 EGR1 NM_001993 F3 NM_001999 FBN2 NM_002015 FOXO1A NM_002017 FLI1 NM_002023 FMOD NM_002033 FUT4 NM_002046 GAPD NM_002049 GATA1 NM_002064 GLRX NM_002065 GLUL NM_002067 GNA11 NM_002068 GNA15 NM_002076 GNS NM_002086 GRB2 NM_002090 CXCL3 NM_002094 GSPT1 NM_002102 GYPE NM_002107 H3F3A NM_002108 HAL NM_002110 HCK NM_002118 HLA-DMB NM_002121 HLA-DPB1 NM_002128 HMGB1 NM_002129 HMGB2 NM_002135 NR4A1 NM_002141 HOXA4 NM_002145 HOXB2 NM_002162 ICAM3 NM_002166 ID2 NM_002167 ID3 NM_002186 IL9R NM_002193 INHBB NM_002198 IRF1 NM_002199 IRF2 NM_002222 ITPR1 NM_002224 ITPR3 NM_002228 JUN NM_002229 JUNB NM_002230 JUP NM_002248 KCNN1 NM_002276 KRT19 NM_002295 LAMR1 NM_002312 LIG4 NM_002341 LTB NM_002349 LY75 NM_002351 SH2D1A NM_002353 TACSTD2 NM_002356 MARCKS NM_002379 MATN1 NM_002388 MCM3 NM_002390 ADAM11 NM_002392 MDM2 NM_002393 MDM4 NM_002398 MEIS1 NM_002412 MGMT NM_002414 CD99 NM_002415 MIF NM_002417 MKI67 NM_002419 MAP3K11 NM_002421 MMP1 NM_002422 MMP3 NM_002436 MPP1 NM_002441 MSH5 NM_002444 MSN NM_002447 MST1R NM_002460 IRF4 NM_002462 MX1 NM_002466 MYBL2 NM_002475 MLC1SA NM_002483 CEACAM6 NM_002512 NME2 NM_002514 NOV NM_002527 NTF3 NM_002530 NTRK3 NM_002572 PAFAH1B2 NM_002576 PAK1 NM_002585 PBX1 NM_002592 PCNA NM_002600 PDE4B NM_002608 PDGFB NM_002609 PDGFRB NM_002616 PER1 NM_002619 PF4 NM_002621 PFC NM_002648 PIM1 NM_002658 PLAU NM_002659 PLAUR NM_002687 PNN NM_002704 PPBP NM_002729 HHEX NM_002730 PRKACA NM_002744 PRKCZ NM_002753 MAPK10 NM_002758 MAP2K6 NM_002791 PSMA6 NM_002800 PSMB9 NM_002814 PSMD10 NM_002827 PTPN1 NM_002831 PTPN6 NM_002835 PTPN12 NM_002844 PTPRK NM_002856 PVRL2 NM_002868 RAB5B NM_002870 RAB13 NM_002880 RAF1 NM_002887 RARS NM_002893 RBBP7 NM_002901 RCN1 NM_002908 REL NM_002913 RFC1 NM_002934 RNASE2 NM_002935 RNASE3 NM_002936 RNASEH1 NM_002953 RPS6KA1 NM_002960 S100A3 NM_002961 S100A4 NM_002971 SATB1 NM_002972 SBF1 NM_002975 CLEC11A NM_002983 CCL3 NM_002984 CCL4 NM_002985 CCL5 NM_003002 SDHD NM_003005 SELP NM_003006 SELPLG NM_003009 SEPW1 NM_003025 SH3GL1 NM_003038 SLC1A4 NM_003039 SLC2A5 NM_003058 SLC22A2 NM_003072 SMARCA4 NM_003073 SMARCB1 NM_003100 SNX2 NM_003113 SP100 NM_003118 SPARC NM_003120 SPI1 NM_003121 SPIB NM_003123 SPN NM_003127 SPTAN1 NM_003128 SPTBN1 NM_003133 SRP9 NM_003159 CDKL5 NM_003189 TAL1 NM_003200 TCF3 NM_003222 TFAP2C NM_003225 TFF1 NM_003234 TFRC NM_003262 TLOC1 NM_003288 TPD52L2 NM_003302 TRIP6 NM_003311 PHLDA2 NM_003315 DNAJC7 NM_003318 TTK NM_003352 SUMO1 NM_003361 UMOD NM_003383 VLDLR NM_003390 WEE1 NM_003395 WNT9A NM_003403 YY1 NM_003415 ZNF268 NM_003425 ZNF45 NM_003427 ZNF76 NM_003453 ZNF198 NM_003467 CXCR4 NM_003480 MEAP5 NM_003549 HYAL3 NM_003582 DYRK3 NM_003627 SLC43A1 NM_003636 KCNAB2 NM_003645 SLC27A2 NM_003692 TMEFF1 NM_003701 TNESF11 NM_003707 RUVBL1 NM_003739 AKR1C3 NM_003746 DNCL1 NM_003753 EIF3S7 NM_003801 GPAA1 NM_003805 CRADD NM_003821 RIPK2 NM_003824 FADD NM_003842 TNFRSF10B NM_003852 TIF1 NM_003874 CD84 NM_003877 SOCS2 NM_003879 CFLAR NM_003884 PCAF NM_003900 SQSTM1 NM_003902 FUBP1 NM_003914 CCNA1 NM_003954 MAP3K14 NM_003955 SOCS3 NM_003974 DOK2 NM_003998 NFKB1 NM_004039 ANXA2 NM_004047 ATP6V0B NM_004064 CDKN1B NM_004067 CHN2 NM_004077 CS NM_004083 DDIT3 NM_004088 DNTT NM_004093 EFNB2 NM_004099 STOM NM_004104 FASN NM_004111 FEN1 NM_004119 FLT3 NM_004177 STX3A NM_004208 PDCD8 NM_004221 NK4 NM_004235 KLF4 NM_004310 RHOH NM_004313 ARRB2 NM_004320 ATP2A1 NM_004324 BAX NM_004335 BST2 NM_004336 BUB1 NM_004343 CALR NM_004355 CD74 NM_004374 COX6C NM_004380 CREBBP NM_004385 CSPG2 NM_004413 DPEP1 NM_004425 ECM1 NM_004430 EGR3 NM_004448 ERBB2 NM_004449 ERG NM_004454 ETV5 NM_004475 FLOT2 NM_004494 HDGF NM_004501 HNRPU NM_004508 IDI1 NM_004513 IL16 NM_004526 MCM2 NM_004530 MMP2 NM_004557 NOTCH4 NM_004583 RAB5C NM_004615 TM4SF2 NM_004624 VIPR1 NM_004633 IL1R2 NM_004642 CDK2AP1 NM_004688 NMI NM_004689 MTA1 NM_004706 ARHGEF1 NM_004725 BUB3 NM_004815 PARG1 NM_004827 ABCG2 NM_004867 ITM2A NM_004924 ACTN4 NM_004936 CDKN2B NM_004938 DAPK1 NM_004941 DHX8 NM_004972 JAK2 NM_004994 MMP9 NM_004997 MYBPH NM_005012 ROR1 NM_005080 XBP1 NM_005084 PLA2G7 NM_005085 NUP214 NM_005098 MSC NM_005104 BRD2 NM_005123 NR1H4 NM_005157 ABL1 NM_005161 AGTRL1 NM_005178 BCL3 NM_005187 CBFA2T3 NM_005192 CDKN3 NM_005197 CHES1 NM_005215 DCC NM_005225 E2F1 NM_005230 ELK3 NM_005239 ETS2 NM_005245 FAT NM_005246 FER NM_005248 FGR NM_005252 FOS NM_005263 GFI1 NM_005317 GZMM NM_005318 H1F0 NM_005334 HCFC1 NM_005335 HCLS1 NM_005339 HIP2 NM_005340 HINT1 NM_005356 LCK NM_005375 MYB NM_005385 NKTR NM_005424 TIE1 NM_005427 TP73 NM_005439 MLF2 NM_005494 DNAJB6 NM_005504 BCAT1 NM_005521 TLX1 NM_005529 HSPG2 NM_005533 IFI35 NM_005556 KRT7 NM_005563 STMN1 NM_005566 LDHA NM_005572 LMNA NM_005583 LYL1 NM_005589 ALDH6A1 NM_005608 PTPRCAP NM_005621 S100A12 NM_005651 TDO2 NM_005654 NR2F1 NM_005671 D8S2298E NM_005687 FARSLB NM_005730 CTDSP2 NM_005731 ARPC2 NM_005738 ARL4A NM_005761 PLXNC1 NM_005767 P2RY5 NM_005781 TNK2 NM_005794 DHRS2 NM_005808 CTDSPL NM_005809 PRDX2 NM_005826 HNRPR NM_005835 SLC17A2 NM_005845 ABCC4 NM_005870 SAP18 NM_005895 GOLGA3 NM_005900 SMAD1 NM_005902 SMAD3 NM_005907 MAN1A1 NM_005911 MAT2A NM_005923 MAP3K5 NM_005933 MLL NM_005936 MLLT4 NM_005944 CD200 NM_005954 MT3 NM_005956 MTHFD1 NM_005957 MTHFR NM_005965 MYLK NM_006005 WFS1 NM_006017 PROM1 NM_006038 SPATA2 NM_006060 ZNFN1A1 NM_006079 CITED2 NM_006082 K-APHA-1 NM_006084 ISGF3G NM_006098 GNB2L1 NM_006101 KNTC2 NM_006113 VAV3 NM_006120 HLA-DMA NM_006142 SFN NM_006152 LRMP NM_006184 NUCB1 NM_006185 NUMA1 NM_006187 OAS3 NM_006190 ORC2L NM_006191 PA2G4 NM_006196 PCBP1 NM_006209 ENPP2 NM_006216 SERPINE2 NM_006230 POLD2 NM_006231 POLE NM_006235 POU2AF1 NM_006255 PRKCH NM_006263 PSME1 NM_006268 DPF2 NM_006273 CCL7 NM_006286 TFDP2 NM_006299 ZNF193 NM_006301 MAP3K12 NM_006302 GCS1 NM_006325 RAN NM_006329 FBLN5 NM_006343 MERTK NM_006354 TADA3L NM_006355 TRIM38 NM_006362 NXF1 NM_006427 SIVA NM_006472 TXNIP NM_006495 EVI2B NM_006509 RELB NM_006522 WNT6 NM_006534 NCOA3 NM_006559 KHDRBS1 NM_006565 CTCF NM_006579 EBP NM_006591 POLD3 NM_006602 TCFL5 NM_006676 USP20 NM_006739 MCM5 NM_006747 SIPA1 NM_006748 SLA NM_006759 UGP2 NM_006762 LAPTM5 NM_006769 LMO4 NM_006803 AP3M2 NM_006820 IFI44L NM_006825 CKAP4 NM_006845 KIF2C NM_006857 RY1 NM_006875 PIM2 NM_006904 PRKDC NM_006910 RBBP6 NM_006931 SLC2A3 NM_006932 SMTN NM_006937 SUMO2 NM_006938 SNRPD1 NM_006963 ZNF22 NM_006981 NR4A3 NM_006994 BTN3A3 NM_007022 CYB561D2 NM_007063 TBC1D8 NM_007065 CDC37 NM_007079 PTP4A3 NM_007111 TFDP1 NM_007117 TRH NM_012092 ICOS NM_012120 CD2AP NM_012207 HNRPH3 NM_012223 MYO1B NM_012267 HSPBP1 NM_012317 LDOC1 NM_012323 MAFF NM_012334 MYO10 NM_012384 GMEB2 NM_012417 PITPNC1 NM_012423 RPL13A NM_013282 UHRF1 NM_013314 BLNK NM_013416 NCF4 NM_014005 PCDHA6 NM_014207 CD5 NM_014232 VAMP2 NM_014244 ADAMTS2 NM_014298 QPRT NM_014345 ZNF318 NM_014365 HSPB8 NM_014575 SCHIP1 NM_014595 NT5C NM_014614 PSME4 NM_014624 S100A6 NM_014667 VGLL4 NM_014707 HDAC9 NM_014724 ZNF305 NM_014734 KIAA0247 NM_014735 PHF16 NM_014780 CUL7 NM_014792 KIAA0125 NM_014824 FCHSD2 NM_014890 DOC1 NM_014899 RHOBTB3 NM_014914 CENTG2 NM_015050 KIAA0082 NM_015069 ZNE423 NM_015099 CAMTA2 NM_015147 KIAA0582 NM_015149 RGL1 NM_015158 ANKRD15 NM_015166 MLC1 NM_015196 KIAA0922 NM_015210 KIAA0802 NM_015261 KIAA0056 NM_015335 THRAP2 NM_015436 RCHY1 NM_015458 MTMR9 NM_015474 SAMHD1 NM_015528 RNF167 NM_015568 PPP1R16B NM_015570 AUTS2 NM_015636 ELF2B4 NM_015670 SENP3 NM_015710 GLTSCR2 NM_015833 ADARB1 NM_015855 WIT-1 NM_015869 PPARG NM_015965 GRIM19 NM_016041 DERL2 NM_016091 EIF3S6IP NM_016184 CLECSF6 NM_016195 MPHOSPH1 NM_016221 DCTN4 NM_016308 UMP-CMPK NM_016343 CENPF NM_016570 PTX1 NM_016734 PAX5 NM_017437 CPSF2 NM_017448 LDHC NM_017617 NOTCH1 NM_017771 PXK NM_017787 C10orf26 NM_017794 KIAA1797 NM_018136 ASPM NM_018209 ARFGAP1 NM_018248 FLJ10858 NM_018462 C3orf10 NM_018664 SNFT NM_018951 HOXA10 NM_019028 ZDHHC13 NM_019071 ING3 NM_019102 HOXA5 NM_019111 HLA-DRA NM_019841 TRPV5 NM_019846 CCL28 NM_019857 CTPS2 NM_020310 MNT NM_020368 SAS10 NM_020371 AVEN NM_020631 KIAA0720 NM_020657 ZNF304 NM_020841 OSBPL8 NM_020843 ZNF291 NM_020892 DTX2 NM_020944 GBA2 NM_020956 PRX NM_020998 MST1 NM_021019 MYL6 NM_021025 TLX3 NM_021038 MBNL1 NM_021071 DO NM_021103 TMSB10 NM_021111 RECK NM_021114 SPINK2 NM_021603 FXYD2 NM_021643 TRIB2 NM_021814 ELOVL5 NM_021906 USP9X NM_021949 ATP2B3 NM_021960 MCL1 NM_022067 C14orf133 NM_022127 SLC28A3 NM_022161 BIRC7 NM_022334 ITGB1BP1 NM_022366 TFB2M NM_022436 ABCG5 NM_022438 MAL NM_022469 GREM2 NM_022549 FEZ1 NM_022716 PRRX1 NM_024006 VKORC1 NM_024099 MGC2477 NM_024319 C1orf35 NM_024408 NOTCH2 NM_024424 WT1 NM_024713 C15orf29 NM_024728 C7orf10 NM_025263 PRR3 NM_030660 ATXN3 NM_030674 SLC38A1 NM_030915 LBH NM_030926 ITM2C NM_030935 THG-1 NM_031243 HNRPA2B1 NM_031423 CDCA1 NM_031966 CCNB1 NM_032121 DKFZp564K142 NM_033238 PML NM_033512 TSPYL5 NM_033554 HLA-DPA1 NM_033642 FGF13 NM_057168 WNT16 NM_058195 CDKN2A NM_080284 ABCA6 NM_080700 TREX2 NM_130439 MXI1 NM_133259 LRPPRC NM_133378 TTN NM_138714 NFAT5 NM_144578 C14orf32 NM_144628 TBC1D20 NM_145698 ACBD5 NM_145867 LTC4S NM_147180 PPP3R2 NM_152739 HOXA9 NM_152788 EB-1 NM_152827 SNX3 NM_152890 COL24A1 NM_156038 CSF3R NM_172020 POM121 NM_173156 C1orf16 NM_173216 SIAT1 NM_173609 C15orf21 NM_173852 KRTCAP2 NM_175739 SERPINA9 NM_175744 RHOC NM_178586 PPP2R5C NM_181311 TAZ NM_181336 LEMD2 NM_181339 IL24 NM_181430 FOXK2 NM_181493 ITPA NM_181702 GEM NM_182729 TXNRD1 NM_182810 ATF4 NM_183395 CIAS1 NM_198232 RNASE1 NM_198400 NEDD4 NM_199335 FYB NM_199423 WWP2 NM_201592 GPM6A NM_201632 TCF7 NM_201998 SF1 NM_212474 FN1 R14777 CYFIP2 R56397 PIK3C3 R59027 GRP58 R72151 GNL3 R79128 MAP3K1 R86893 C6orf110 T07281 NRIP1 T28925 ITGAL U60115 FHL1 U79271 AKT3 W04885 MYL4 X66087 MYBL1 AK024272 AK025231 IGLC2 AL080190 BU618233 NM_001353.4 AKR1C1

Accordingly, one embodiment of the present invention provides for a library of candidate genes suitable for profiling hematological cancers. In a further embodiment, the library of candidate genes comprises the genes set forth in Table 1. The library provides a resource from which genes appropriate for inclusion in a HCP sets can be selected.

Once candidate genes have been identified, an HCP set is formed by selecting those genes relating to the hematological cancer of interest that are indicative of features of the hematological cancer that are to be investigated. If more than one hematological cancer is to be investigated, or more than one sub-type of a hematological cancer is to be investigated, then different HCP sets can be formed containing genes that are indicative of the feature(s) of interest. For example if lymphoma and leukemia are to be investigated, then different HCP sets can be created, each one relating to a sub-type of lymphoma or a sub-type of leukemia and containing genes that are indicative of the feature(s) of interest.

It will be readily apparent that some genes are suitable for inclusion in more than one HCP set. For example, a gene that allows two lymphomas to be distinguished, such as DLBCL and FL, would be suitable for inclusion in an HCP set relating to DLBCL as well as an HCP set relating to FL. Alternatively, a gene that allows two leukemias to be distinguished, for example CLL and AML, would be suitable for inclusion in an HCP set relating to CLL as well as an HCP set relating to AML. Examples of genes that may be included in more than one HCP set are: AKR1C1, MAL (T-cell differentiation protein), and TIMP1.

The HCP set can comprise between one and about 2000 genes, depending on the number of features of the lymphoma the set is intended to represent. When the set comprises more than one gene, each gene of the set can relate to a different feature of the hematological cancer, or multiple genes within the HCP set can relate to the same feature. Thus, the HCP set can comprise genes that are indicative of one feature of a hematological cancer, genes that are indicative of more than one feature of a hematological cancer, or combinations thereof.

In one embodiment, the HCP set comprises at least 5 genes. In another embodiment, the HCP set comprises at least 10 genes. In a further embodiment, the HCP set comprises at least 15 genes. In other embodiments, the HCP set comprises at least 20, at least 25, at least 30, at least 35, and at least 40 genes. As indicated above, the HCP set typically comprises less than 2000 genes. In one embodiment of the present invention, therefore, the HCP set comprises between about 5 and about 2000 genes. In another embodiment, the HCP set comprises between about 5 and about 1500 genes. In a further embodiment, the HCP set comprises between about 5 and about 1000 genes. In other embodiments, the HCP set comprises between about 5 and about 750 genes, between about 5 and about 500 genes, between about 5 and about 400 genes, and between about 5 and about 300 genes. In other embodiments, the HCP set comprises between about 10 and about 1500 genes, between about 15 and about 1000 genes, between about 20 and about 750 genes, between about 25 and about 500 genes, between about 30 and about 400 genes, between about 30 and about 300 genes, and between about 30 and about 250 genes.

As indicated above, the HCP set is representative of at least one feature of a hematological cancer. In one embodiment of the present invention, the HCP set is representative of two or more features of a specific hematological cancer. In another embodiment, the HCP set is representative of between one and 20 features of a specific hematological cancer. In a further embodiment, the HCP set is representative of between 2 and 20 features of a specific hematological cancer. In yet another embodiment, the HCP set is representative of between 3 and 20 features of a specific hematological cancer. In other embodiments, the HCP set is representative of between one and 18, between one and 16, between one and 14 features, and between one and 12 features of a specific hematological cancer.

In one embodiment of the present invention, genes for inclusion in the HCP sets are selected from the genes set forth in Table 1. Representative, non-limiting examples of HCP sets are provided in Tables 2-19 below. Additional HCP sets representing other hematological cancers, types or sub-types of hematological cancers, or one or more features thereof, can be readily formed by the skilled worker having reference to the genes set forth in Table 1.

The present invention contemplates that these HCP sets can be used as the basis for forming expanded HCP sets that include additional genes to those listed for each set in the Tables below as well as reduced HCP sets from which some, or most, of the genes have been removed. One skilled in the art will also appreciate that combinations of the genes listed in Tables 2-19 below can be used to form additional HCP sets, the genes being selected based on the hematological cancer and features thereof to be investigated. Thus, HCP sets can be formed by combining one or more genes selected from one of the HCP sets provided in Tables 2-19 with one or more genes selected from at least one of the other HCP sets provided in Tables 2-19. All such sets are considered to be within the scope of the invention.

TABLE 2 An HCP set specific for lymphoma, according to one embodiment of the invention: Accession Symbol AA594161.1 MYH11 AA766908.1 MME AB014540.1 SWAP70 AF196185.1 PARD3 AI597616.1 MRPL33 AI634809.1 ARID5B AI672553.1 AKAP12 AI809213.1 RGS13 AK022231.1 STAT1 AK022293.1 CTSD AK055652.1 C3orf6 AL080130.1 FLJ14001 AL833316.1 MIR AW271958.1 TYMS AW291384.1 STS-1 BE897089.1 ZNF91 BG993697.1 SMYD3 BI769730.1 HLA-DRB1 BQ632574.1 RASA1 BX504817.1 SFRS7 H53164.1 IRF8 H57732.1 TGFBR2 L29376.1 3.8-1 M80899.1 MGC5395 NM_000038.2 APC NM_000043.3 FAS NM_000061.1 BTK NM_000075.2 CDK4 NM_000109.2 DMD NM_000189.4 HK2 NM_000237.1 LPL NM_000269.2 NME1 NM_000271.1 NPC1 NM_000295.3 SERPINA1 NM_000313.1 PROS1 NM_000397.2 CYBB NM_000405.3 GM2A NM_000424.2 KRT5 NM_000483.3 APOC2 NM_000576.2 IL1B NM_000579.1 CCR5 NM_000584.2 IL8 NM_000585.2 IL15 NM_000600.1 IL6 NM_000626.1 CD79B NM_000627.2 LTBP1 NM_000633.1 BCL2 NM_000655.2 SELL NM_000713.1 BLVRB NM_000785.2 CYP27B1 NM_000788.1 DCK NM_000853.1 GSTT1 NM_000873.2 ICAM2 NM_000877.2 IL1R1 NM_000917.1 P4HA1 NM_000927.3 ABCB1 NM_001067.2 TOP2A NM_001068.2 TOP2B NM_001110.1 ADAM10 NM_001154.2 ANXA5 NM_001166.3 BIRC2 NM_001196.2 BID NM_001197.3 BIK NM_001230.3 CASP10 NM_001238.1 CCNE1 NM_001242.3 TNFRSF7 NM_001254.2 CDC6 NM_001350.2 DAXX NM_001353.4 AKR1C1 NM_001425.1 EMP3 NM_001552.1 IGFBP4 NM_001558.2 IL10RA NM_001618.2 PARP1 NM_001621.2 AHR NM_001647.1 APOD NM_001663.2 ARF6 NM_001706.2 BCL6 NM_001760.2 CCND3 NM_001762.2 CCT6A NM_001770.3 CD19 NM_001771.1 CD22 NM_001779.1 CD58 NM_001781.1 CD69 NM_001782.1 CD72 NM_001826.1 CKS1B NM_001827.1 CKS2 NM_001831.2 CLU NM_001852.3 COL9A2 NM_001853.2 COL9A3 NM_001877.2 CR2 NM_001888.1 CRYM NM_001894.4 CSNK1E NM_001951.2 E2F5 NM_001967.2 EIF4A2 NM_002002.3 FCER2 NM_002051.2 GATA3 NM_002095.3 GTF2E2 NM_002101.3 GYPC NM_002105.1 H2AFX NM_002120.2 HLA-DOB NM_002122.2 HLA-DQA1 NM_002155.3 HSPA6 NM_002189.2 IL15RA NM_002211.2 ITGB1 NM_002217.1 ITIH3 NM_002250.2 KCNN4 NM_002305.2 LGALS1 NM_002306.1 LGALS3 NM_002350.1 LYN NM_002358.2 MAD2L1 NM_002426.1 MMP12 NM_002467.2 MYC NM_002526.1 NT5E NM_002567.2 PBP NM_002646.2 PIK3C2B NM_002661.1 PLCG2 NM_002692.2 POLE2 NM_002738.5 PRKCB1 NM_002752.3 MAPK9 NM_002832.2 PTPN7 NM_002838.2 PTPRC NM_002891.3 RASGRF1 NM_002892.2 ARID4A NM_002943.2 RORA NM_002966.1 S100A10 NM_002967.2 SAFB NM_003037.1 SLAMF1 NM_003088.2 FSCN1 NM_003177.3 SYK NM_003217.1 TEGT NM_003226.2 TFF3 NM_003243.1 TGFBR3 NM_003254.1 TIMP1 NM_003290.1 TPM4 NM_003299.1 TRA1 NM_003332.2 TYROBP NM_003362.2 UNG NM_003451.1 ZNF177 NM_003648.2 DGKD NM_003656.3 CAMK1 NM_003810.2 TNFSF10 NM_003875.1 GMPS NM_003915.2 RBM12 NM_003959.1 HIP1R NM_004049.2 BCL2A1 NM_004073.2 PLK3 NM_004091.2 E2F2 NM_004117.2 FKBP5 NM_004125.2 GNG10 NM_004126.2 GNG11 NM_004184.3 WARS NM_004271.1 LY86 NM_004289.5 NFE2L3 NM_004322.2 BAD NM_004354.1 CCNG2 NM_004356.2 CD81 NM_004358.3 CDC25B NM_004422.2 DVL2 NM_004445.1 EPHB6 NM_004460.2 FAP NM_004510.2 SP110 NM_004529.1 MLLT3 NM_004556.1 NFKBIE NM_004577.3 PSPH NM_004619.2 TRAF5 NM_004635.3 MAPKAPK3 NM_004737.2 LARGE NM_004844.1 SH3BP5 NM_004851.1 NAPSA NM_004951.2 EBI2 NM_005013.1 NUCB2 NM_005077.3 TLE1 NM_005127.2 CLECSF2 NM_005211.2 CSF1R NM_005213.2 CSTA NM_005214.2 CTLA4 NM_005271.1 GLUD1 NM_005292.2 GPR18 NM_005347.2 HSPA5 NM_005348.2 HSPCA NM_005415.3 SLC20A1 NM_005449.3 TOSO NM_005461.3 MAFB NM_005531.1 IFI16 NM_005582.1 LY64 NM_005601.3 NKG7 NM_005606.3 LGMN NM_005610.1 RBBP4 NM_005623.2 CCL8 NM_005638.3 SYBL1 NM_005652.2 TERF2 NM_005658.2 TRAF1 NM_005856.1 RAMP3 NM_005935.1 MLLT2 NM_005950.1 MT1G NM_005951.1 MT1H NM_006006.3 ZBTB16 NM_006014.2 DXS9879E NM_006115.3 PRAME NM_006162.3 NFATC1 NM_006164.2 NFE2L2 NM_006195.2 PBX3 NM_006218.1 PIK3CA NM_006254.3 PRKCD NM_006257.2 PRKCQ NM_006274.2 CCL19 NM_006317.3 BASP1 NM_006332.3 IFI30 NM_006475.1 POSTN NM_006498.1 LGALS2 NM_006558.1 KHDRBS3 NM_006620.2 HBS1L NM_006644.2 HSPH1 NM_006734.2 HIVEP2 NM_006761.3 YWHAE NM_006763.2 BTG2 NM_006841.3 SLC38A3 NM_006889.2 CD86 NM_006892.3 DNMT3B NM_006986.2 MAGED1 NM_007311.2 BZRP NM_007360.1 KLRK1 NM_007361.2 NID2 NM_012203.1 GRHPR NM_012448.3 STAT5B NM_012452.2 TNFRSF13B NM_013230.1 CD24 NM_014246.1 CELSR1 NM_014257.3 CD209L NM_014338.3 PISD NM_014456.3 PDCD4 NM_014686.2 KIAA0355 NM_014762.1 DHCR24 NM_015187.1 KIAA0746 NM_015641.2 TES NM_015866.2 PRDM2 NM_016076.2 PNAS-4 NM_016081.2 KIAA0992 NM_016187.1 BIN2 NM_016336.2 UBE2J1 NM_016628.2 WAC NM_017530.1 LOC55565 NM_017784.3 OSBPL10 NM_017935.2 BANK1 NM_017955.2 CDCA4 NM_018442.1 IQWD1 NM_018842.3 BAIAP2L1 NM_020151.2 STARD7 NM_020199.1 C5orf15 NM_020529.1 NFKBIA NM_020992.2 PDLIM1 NM_021813.1 BACH2 NM_021822.1 APOBEC3G NM_021950.2 MS4A1 NM_021966.1 TCL1A NM_022552.3 DNMT3A NM_023037.1 13CDNA73 NM_024708.2 ASB7 NM_025113.1 C13orf18 NM_025216.2 WNT10A NM_030666.2 SERPINB1 NM_030764.2 SPAP1 NM_030775.2 WNT5B NM_031305.1 ARHGAP24 NM_031942.3 CDCA7 NM_032991.1 CASP3 NM_033208.2 TIGD7 NM_033274.1 ADAM19 NM_057735.1 CCNE2 NM_078467.1 CDKN1A NM_079421.2 CDKN2D NM_080593.1 HIST1H2BK NM_080881.1 DBN1 NM_138340.3 ABHD3 NM_138379.1 TIMD4 NM_139207.1 NAP1L1 NM_139276.2 STAT3 NM_144646.2 IGJ NM_145804.1 ABTB2 NM_152785.2 GCET2 NM_172373.2 ELF1 NM_173624.1 FLJ40504 NM_175870.3 LOC90925 NM_177968.1 PPM1B NM_181443.1 BTBD3 NM_181838.1 UBE2D2 NM_182746.1 MCM4 NM_182776.1 MCM7 NM_198833.1 SERPINB8 NM_201593.1 CACNB2 R99527.1 MGC39372 T66903.1 LOC54103 U37028.1 ITGAD U90916.1 SORL1 W56129.1 SFRS9 X58529.1 IGHM

TABLE 3 An HCP set specific for leukemia, according to one embodiment of the invention GenBank ™ Accession No. Name Symbol W04885.1 Myosin, light polypeptide 4, alkali; atrial, embryonic MYL4 NM_013230.1 CD24 antigen (small cell lung carcinoma cluster 4 antigen) CD24 NM_173624.1 Hypothetical protein FLJ40504 FLJ40504 NM_002276.3 Keratin 19 KRT19 NM_002102.2 Glycophorin E GYPE BC058855.1 Vascular endothelial growth factor VEGF NM_001353.4 Aldo-keto reductase family 1, member C2 (dihydrodiol AKR1C1 dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) NM_002358.2 MAD2 mitotic arrest deficient-like 1 (yeast) MAD2L1 NM_018136.2 Asp (abnormal spindle)-like, microcephaly associated ASPM (Drosophila) NM_005192.2 Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual CDKN3 specificity phosphatase) NM_001168.1 Baculoviral IAP repeat-containing 5 (survivin) BIRC5 NM_006845.2 Kinesin family member 2C KIF2C NM_031966.2 Cyclin B1 CCNB1 NM_001255.1 CDC20 cell division cycle 20 homolog (S. cerevisiae) CDC20 NM_001237.2 Cyclin A2 CCNA2 NM_001067.2 Topoisomerase (DNA) II alpha 170 kDa TOP2A NM_003234.1 Transferrin receptor (p90, CD71) TFRC NM_006101.1 Kinetochore associated 2 KNTC2 NM_003038.2 Solute carrier family 1 (glutamate/neutral amino acid SLC1A4 transporter), member 4 NM_018842.3 BAI1-associated protein 2-like 1 BAIAP2L1 NM_006115.3 Preferentially expressed antigen in melanoma PRAME NM_031942.3 Cell division cycle associated 7 CDCA7 NM_031423.2 Cell division cycle associated 1 CDCA1 NM_001786.2 Cell division cycle 2, G1 to S and G2 to M CDC2 NM_001254.2 CDC6 cell division cycle 6 homolog (S. cerevisiae) CDC6 NM_002692.2 Polymerase (DNA directed), epsilon 2 (p59 subunit) POLE2 NM_005563.3 Stathmin 1/oncoprotein 18 STMN1 NM_001274.2 CHK1 checkpoint homolog (S. pombe) CHEK1 NM_004577.3 Phosphoserine phosphatase PSPH NM_005951.1 Metallothionein 1H MT1H NM_005950.1 Metallothionein 1G MT1G NM_022438.1 Mal, T-cell differentiation protein MAL NM_002051.2 GATA binding protein 3 GATA3 NM_006748.1 Src-like-adaptor SLA NM_005077.3 Transducin-like enhancer of split 1 (E(sp1) homolog, TLE1 Drosophila) BE927772.1 Splicing factor, arginine/serine-rich 3 SFRS3 NM_004615.2 Transmembrane 4 superfamily member 2 TM4SF2 NM_000536.1 Recombination activating gene 2 RAG2 NM_004088.2 Deoxynucleotidyltransferase, terminal DNTT NM_000700.1 Annexin A1 ANXA1 NM_201632.1 Transcription factor 7 (T-cell specific, HMG-box) TCF7 NM_000732.2 CD3D antigen, delta polypeptide (TiT3 complex) CD3D NM_004221.3 Interleukin 32 NK4 NM_005601.3 Natural killer cell group 7 sequence NKG7 NM_002838.2 Protein tyrosine phosphatase, receptor type, C PTPRC NM_003467.1 Chemokine (C—X—C motif) receptor 4 CXCR4 NM_001767.2 CD2 antigen (p50), sheep red blood cell receptor CD2 NM_005356.2 Lymphocyte-specific protein tyrosine kinase LCK NM_006734.2 Human immunodeficiency virus type I enhancer binding protein 2 HIVEP2 NM_002412.2 O-6-methylguanine-DNA methyltransferase MGMT NM_001079.3 Zeta-chain (TCR) associated protein kinase 70 kDa ZAP70 NM_005608.1 Protein tyrosine phosphatase, receptor type, C-associated PTPRCAP protein NM_002831.3 Protein tyrosine phosphatase, non-receptor type 6 PTPN6 T28925.1 Integrin, alpha L (antigen CD11A (p180), lymphocyte function- ITGAL associated antigen 1; alpha polypeptide) NM_005531.1 Interferon, gamma-inducible protein 16 IFI16 NM_012151.2 Coagulation factor VIII-associated (intronic transcript) 1 F8A1 NM_000109.2 Dystrophin (muscular dystrophy, Duchenne and Becker types) DMD AI672553.1 A kinase (PRKA) anchor protein (gravin) 12 AKAP12 BU929213.1 Sestrin 3 SESN3 AL049313.1 Chloride intracellular channel 5 CLIC5 NM_000856.1 Guanylate cyclase 1, soluble, alpha 3 GUCY1A3 NM_005965.3 Myosin, light polypeptide kinase MYLK NM_000237.1 Lipoprotein lipase LPL AI307786.1 Transcription factor 4 TCF4 NM_000089.3 Collagen, type I, alpha 2 COL1A2 NM_001839.2 Calponin 3, acidic CNN3 NM_006209.2 Ectonucleotide pyrophosphatase/phosphodiesterase 2 ENPP2 (autotaxin) NM_000062.1 Serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), SERPING1 member 1, (angioedema, hereditary) NM_002658.1 Plasminogen activator, urokinase PLAU NM_212474.1 Fibronectin 1 FN1 NM_001901.1 Connective tissue growth factor CTGF NM_003302.1 Thyroid hormone receptor interactor 6 TRIP6 NM_000305.1 Paraoxonase 2 PON2 AK055652.1 Chromosome 3 open reading frame 6 C3orf6 NM_003821.4 Receptor-interacting serine-threonine kinase 2 RIPK2 BC050602.1 histone 1, H2ac HIST1H2AC NM_002870.2 RAB13, member RAS oncogene family RAB13 NM_007311.2 Benzodiazapine receptor (peripheral) BZRP NM_030666.2 Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), SERPINB1 member 1 NM_003254.1 Tissue inhibitor of metalloproteinase 1 (erythroid potentiating TIMP1 activity, collagenase inhibitor) NM_198232.1 Ribonuclease, RNase A family, 1 (pancreatic) RNASE1 NM_015149.2 Ral guanine nucleotide dissociation stimulator-like 1 RGL1 NM_025113.1 Chromosome 13 open reading frame 18 C13orf18 NM_021966.1 T-cell leukemia/lymphoma 1A TCL1A NM_002002.3 Fc fragment of IgE, low affinity II, receptor for (CD23A) FCER2 NM_002661.1 Phospholipase C, gamma 2 (phosphatidylinositol-specific) PLCG2 AK022231.1 Signal transducer and activator of transcription 1, 91 kDa STAT1 NM_006317.3 Brain abundant, membrane attached signal protein 1 BASP1 NM_006120.2 Major histocompatibility complex, class II, DM alpha HLA-DMA NM_001774.1 CD37 antigen CD37 NM_144646.2 Immunoglobulin J polypeptide, linker protein for IGJ immunoglobulin alpha and mu polypeptides NM_003121.1 Spi-B transcription factor (Spi-1/PU.1 related) SPIB NM_021950.2 Membrane-spanning 4-domains, subfamily A, member 1 MS4A1 NM_001877.2 Complement component (3d/Epstein Barr virus) receptor 2 CR2 NM_005658.2 TNF receptor-associated factor 1 TRAF1 NM_004513.3 Interleukin 16 (lymphocyte chemoattractant factor) IL16 NM_002341.1 Lymphotoxin beta (TNF superfamily, member 3) LTB AI523104.1 Leukocyte immunoglobulin-like receptor, subfamily B (with LILRB1 TM and ITIM domains), member 1 NM_013416.2 Neutrophil cytosolic factor 4, 40 kDa NCF4 NM_004355.1 CD74 antigen (invariant polypeptide of major CD74 histocompatibility complex, class II antigen-associated) NM_005213.2 Cystatin A (stefin A) CSTA BC042366.1 protocadherin 9 PCDH9 NM_001337.2 Chemokine (C—X3—C motif) receptor 1 CX3CR1 NM_002619.1 Platelet factor 4 (chemokine (C—X—C motif) ligand 4) PF4 NM_002704.2 Pro-platelet basic protein (chemokine (C—X—C motif) ligand 7) PPBP NM_015570.1 Autism susceptibility candidate 2 AUTS2 U90916.1 Sortilin-related receptor, L(DLR class) A repeats-containing SORL1 NM_004049.2 BCL2-related protein A1 BCL2A1 NM_015474.2 SAM domain and HD domain 1 SAMHD1 NM_004951.2 Epstein-Barr virus induced gene 2 (lymphocyte-specific G EBI2 protein-coupled receptor) NM_003037.1 Signaling lymphocytic activation molecule family member 1 SLAMF1 NM_156038.2 Colony stimulating factor 3 receptor (granulocyte) CSF3R NM_005248.1 Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene FGR homolog NM_016184.2 C-type lectin domain family 4, member A CLECSF6 NM_001776.3 Ectonucleoside triphosphate diphosphohydrolase 1 ENTPD1 NM_004851.1 Napsin A aspartic peptidase NAPSA NM_000484.2 Amyloid beta (A4) precursor protein (protease nexin-II, APP Alzheimer disease) NM_000626.1 CD79B antigen (immunoglobulin-associated beta) CD79B NM_001242.3 Tumor necrosis factor receptor superfamily, member 7 TNFRSF7 NM_006820.1 Interferon-induced protein 44-like IFI44L NM_021822.1 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide- APOBEC3G like 3F NM_000061.1 Bruton agammaglobulinemia tyrosine kinase BTK NM_002985.2 Chemokine (C-C motif) ligand 5 CCL5 NM_001558.2 Interleukin 10 receptor, alpha IL10RA NM_006254.3 Protein kinase C, delta PRKCD NM_002306.1 Lectin, galactoside-binding, soluble, 3 (galectin 3) LGALS3 NM_000610.3 CD44 antigen (homing function and Indian blood group system) CD44 NM_004271.1 Lymphocyte antigen 86 LY86 AB014540.1 SWAP-70 protein SWAP70 NM_001165.3 Baculoviral IAP repeat-containing 3 BIRC3 NM_006889.2 CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) CD86 NM_002110.2 Hemopoietic cell kinase HCK NM_003810.2 Tumor necrosis factor (ligand) superfamily, member 10 TNFSF10 T66903.1 Hypothetical protein LOC54103 LOC54103 NM_005335.3 Hematopoietic cell-specific Lyn substrate 1 HCLS1 NM_005767.3 Purinergic receptor P2Y, G-protein coupled, 5 P2RY5 NM_007360.1 Killer cell lectin-like receptor subfamily K, member 1 KLRK1 NM_006498.1 Lectin, galactoside-binding, soluble, 2 (galectin 2) LGALS2 NM_000118.1 Endoglin (Osler-Rendu-Weber syndrome 1) ENG AL050391.1 Caspase 4, apoptosis-related cysteine protease CASP4 NM_005211.2 Colony stimulating factor 1 receptor, formerly McDonough CSF1R feline sarcoma viral (v-fms) oncogene homolog NM_030764.2 SH2 domain containing phosphatase anchor protein 1 SPAP1 NM_001001547.1 CD36 antigen (collagen type I receptor, thrombospondin CD36 receptor) NM_005621.1 S100 calcium binding protein A12 (calgranulin C) S100A12 NM_000295.3 Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 SERPINA1 antiproteinase, antitrypsin), member 1 NM_005084.2 Phospholipase A2, group VII (platelet-activating factor PLA2G7 acetylhydrolase, plasma) NM_021038.3 Muscleblind-like (Drosophila) MBNL1 NM_001553.1 Insulin-like growth factor binding protein 7 IGFBP7 NM_006332.3 Interferon, gamma-inducible protein 30 IFI30 NM_002305.2 Lectin, galactoside-binding, soluble, 1 (galectin 1) LGALS1 NM_002961.2 S100 calcium binding protein A4 (calcium protein, calvasculin, S100A4 metastasin, murine placental homolog) NM_006472.1 Thioredoxin interacting protein TXNIP NM_014624.2 S100 calcium binding protein A6 (calcyclin) S100A6 NM_003332.2 TYRO protein tyrosine kinase binding protein TYROBP NM_033554.2 Major histocompatibility complex, class II, DP alpha 1 HLA-DPA1 NM_002121.4 Major histocompatibility complex, class II, DP beta 1 HLA-DPB1 NM_019111.2 Major histocompatibility complex, class II, DR alpha HLA-DRA

TABLE 4 An HCP set specific for ALCL, according to one embodiment of the invention Feature Accession Symbol Name Notes Level ALCL NM_001831 CLU Clusterin Diagnostic Up in Signature Marker ALCL ALK+ NM_000295 SERPINA1 serine (or cysteine) Genes up Up in vs. ALK− proteinase inhibitor, clade A regulated in ALK+ (ALCL) (aHCPha-1 antiproteinase, ALK+ ALCL ALCL vs antitrypsin), member 1 ALK− ALK+ NM_022743 SMYD3 SET and MYND domain Genes up Up in vs. ALK− containing 3 regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_003217 TEGT testis enhanced gene Genes up Up in vs. ALK− transcript (BAX inhibitor 1) regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_003352 UBL1 ubiquitin-like 1 (sentrin) Genes up Up in vs. ALK− regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_004762 PSCD1 pleckstrin homology, Sec7 Genes up Up in vs. ALK− and coiled-coil domains regulated in ALK+ (ALCL) 1(cytohesin 1) ALK+ ALCL ALCL vs ALK− ALK+ NM_002444 MSN moesin Genes up Up in vs. ALK− regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_006325 RAN RAN, member RAS Genes up Up in vs. ALK− oncogene family regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_006579 EBP emopamil binding protein Genes up Up in vs. ALK− (sterol isomerase) regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_032263 DKFZp434B227 hypothetical protein Genes up Up in vs. ALK− DKFZp434B227 regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_014670 BZW1 basic leucine zipper and W2 Genes up Up in vs. ALK− domains 1 regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_000877 IL1R1 interleukin 1 receptor, type I Genes up Up in vs. ALK− regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_018209 ARFGAP1 ADP-ribosylation factor Genes up Up in vs. ALK− GTPase activating protein 1 regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_001923 DDB1 damage-specific DNA Genes up Up in vs. ALK− binding protein 1, 127 kDa regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_001618 ADPRT ADP-ribosyltransferase Genes up Up in vs. ALK− (NAD+; poly (ADP-ribose) regulated in ALK+ (ALCL) polymerase) ALK+ ALCL ALCL vs ALK− ALK+ NM_021960 MCL1 myeloid cell leukemia Genes up Up in vs. ALK− sequence 1 (BCL2-related) regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_001165 BIRC3 baculoviral IAP repeat- Genes up Up in vs. ALK− containing 3 regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_018462 MDS027 uncharacterized Genes up Up in vs. ALK− hematopoietic regulated in ALK+ (ALCL) stem/progenitor cells protein ALK+ ALCL ALCL vs MDS027 ALK− ALK+ AB032991 NDFIP2 Nedd4 family interacting Genes up Up in vs. ALK− protein 2 regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_000417 IL2RA interleukin 2 receptor, Genes up Up in vs. ALK− aHCPha regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_031966 CCNB1 cyclin B1 Genes up Up in vs. ALK− regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_030674 SLC38A1 solute carrier family 38, Genes up Up in vs. ALK− member 1 regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− ALK+ NM_022366 TFB2M transcription factor B2, Genes up Up in vs. ALK− mitochondrial regulated in ALK+ (ALCL) ALK+ ALCL ALCL vs ALK− HL vs. NM_002228 JUN v-jun sarcoma virus 17 Differentially Up only in ALCL oncogene homolog (avian) regulated HL between ALCL and HL HL vs. NM_002961 S100A4 S100 calcium binding Differentially Up only in ALCL protein A4 (calcium protein, regulated HL calvasculin, metastasin, between ALCL murine placental homolog) and HL HL vs. NM_005178 BCL3 B-cell CLL/lymphoma 3 Diagnostic Up only in ALCL Marker ALCL HL vs. NM_176783 PSME1 proteasome (prosome, Differentially Up only in ALCL macropain) activator subunit regulated ALCL 1 (PA28 aHCPha) between ALCL and HL HL vs. NM_000485 APRT adenine Differentially Up in Both ALCL phosphoribosyltransferase regulated HL and between ALCL ALCL and HL HL vs. NM_001728 BSG basigin (OK blood group) Differentially Up only in ALCL regulated ALCL between ALCL and HL HL vs. NM_006763 BTG2 BTG family member 2 Differentially Up in Both ALCL regulated HL and between ALCL ALCL and HL HL vs. NM_001743 CALM2 calmodulin 2 (phosphorylase Differentially Up in Both ALCL kinase, delta) regulated HL and between ALCL ALCL and HL HL vs. NM_002086 GRB2 growth factor receptor-bound Differentially Up only in ALCL protein 2 regulated HL between ALCL and HL HL vs. NM_005340 HINT1 histidine triad nucleotide Differentially Up only in ALCL binding protein 1 regulated ALCL between ALCL and HL HL vs. NM_006191 PA2G4 proliferation-associated 2G4, Differentially Up in Both ALCL 38 kDa regulated HL and between ALCL ALCL and HL HL vs. NM_030666 SERPINB1 seine (or cysteine) Differentially Up in Both ALCL proteinase inhibitor, clade B regulated HL and (ovalbumin), member 1 between ALCL ALCL and HL HL vs. NM_003955 SOCS3 suppressor of cytokine Differentially Up only in ALCL signaling 3 regulated ALCL between ALCL and HL HL vs. NM_003254 TIMP1 tissue inhibitor of Genes unique Disagreement: ALCL metalloproteinase 1 to Up in (erythroid potentiating Reed/Sternberg HL; Up activity, collagenase cells; only in inhibitor) Differentially ALCL; Up regulated in Fatal; between ALCL Down in and HL; Genes Cured with prognostic value HL vs. NM_033306 CASP4 caspase 4, apoptosis-related Differentially Up only in ALCL cysteine protease regulated ALCL between ALCL and HL Signature; NM_003254 TIMP1 tissue inhibitor of Genes unique Disagreement: HL vs. metalloproteinase 1 to Up in ALCL; (erythroid potentiating Reed/Sternberg HL; Up Survival activity, collagenase cells; only in inhibitor) Differentially ALCL; Up regulated in Fatal; between ALCL Down in and HL; Genes Cured with prognostic value

TABLE 5 An HCP set specific for CLL/SLL, according to one embodiment of the invention Feature Accession Symbol Name Notes Level CLL/SLL NM_020944 GBA2 glucosidase, beta (bile down in vs MCL acid) 2 MCL vs SLL (−5.1) CLL/SLL NM_003222 TFAP2C transcription factor AP- down in 2 gamma (activating CLL/SLL enhancer binding (−7.2) protein 2 gamma) CLL/SLL NM_019846 CCL28 chemokine (C-C motif) up in FL vs FL ligand 28 vs CLL/SLL (5.2) CLL/SLL NM_004827 ABCG2 ATP-binding cassette, down in sub-family G CLL/SLL (WHITE), member 2 (−7.2) CLL/SLL NM_001830 CLCN4 chloride channel 4 down in vs MCL MCL vs SLL (−4.9) CLL vs. NM_000633 BCL2 B-cell CLL/lymphoma 2 CLL signature vs. High in DLBCL DLBCL CLL CLL/SLL NM_001237 CCNA2 cyclin A2 Down in CLL/SLL (−5) CLL vs. NM_053056 CCND1 cyclin D1 MCL, CLL High in MCL (BCL1/PRAD1: Signature&CLL CLL parathyroid Vs. MCL adenomatosis 1) Distinguisher MCL vs NM_003651 CSDA cold shock domain down in CLL/SLL protein A MCL vs SLL (−4.4) CLL vs. NM_002390 ADAM11 a disintegrin and Resting B-cell High in DLBCL metalloproteinase signature CLL domain 11 CLL vs. NM_000698 ALOX5 arachidonate 5- Resting B-cell High in DLBCL lipoxygenase signature CLL CLL vs. NM_001706 BCL6 B-cell CLL/lymphoma High in G-center Low in DLBCL 6 (zinc finger protein type DLBCL CLL; 51) High in G-center DLBCL CLL vs. NM_001197 BIK BCL2-interacting killer High in G-center Low in DLBCL (apoptosis-inducing) type DLBCL CLL; High in G-center DLBCL CLL vs. NM_016187 BIN2 bridging integrator 2 Resting B-cell High in DLBCL signature CLL CLL vs. NM_014207 CD5 CD5 antigen (p56-62) Hs.58685 High in DLBCL CLL CLL vs. NM_001775 CD38 CD38 antigen (p45) Hs.174944; Low in DLBCL Prognostically CLL; significant High in G-center DLBCL CLL/SLL NM_002984 CCL4 chemokine (C-C motif) down in ligand 4 SLL (−8.7) MCL vs NM_002466 MYBL2 v-myb myeloblastosis up in CLL/SLL viral oncogene MCL vs homolog (avian)-like 2 SLL (5.1) CLL/SLL NM_025113 C13orf18 chromosome 13 open up in reading frame 18 SLL (4.8) FL vs NM_025113 C13orf18 chromosome 13 open down in CLL/SLL reading frame 18 FL vs SLL (−5.3) MCL vs NM_032873 KIAA1959 nm23-phosphorylated down in CLL/SLL unknown substrate MCL vs SLL (−5.3) CLL/SLL NM_000633 BCL2 B-cell CLL/lymphoma 2 Up in SLL (4.4) MCL vs NM_000418 IL4R interlekin 4 receptor down in CLL/SLL MCL vs SLL (−7.1) CLL/SLL NM_004630 SF1 splicing factor 1 down in CLL/SLL (−7) CLL/SLL AF509494 KIAA1407 KIAA1407 protein up in SLL (4.1) CLL/SLL NM_006565 CTCF CCCTC-binding factor down in (zinc finger protein) SLL (−4.1); up in FL vs SLL (10.2) CLL/SLL NM_000483 APOC2 apolipoprotein C-II up in vs MCL MCL vs SLL (5.6) CLL/SLL AB018263 KIAA0720 putative NFkB Up in vs MCL activating protein MCL vs SLL (4.3) CLL/SLL NM_003915 CPNE1 copine I up in SLL (7.1); up in FL vs SLL (−4.5) CLL/SLL NM_005248 FGR Gardner-Rasheed feline down in sarcoma viral (v-fgr) FL vs oncogene homolog SLL (−5.8); down in MCL vs SLL (−4.5) CLL/SLL NM_003480 MFAP5 microfibrillar up in vs MCL associated protein 5 MCL vs CLL/SLL (4.2) CLL vs. NM_005248 FGR Gardner-Rasheed feline Resting B-cell High in DLBCL sarcoma viral (v-fgr) signature CLL oncogene homolog MCL vs NM_023037 13CDNA73 hypothetical protein MCL vs CLL/SLL CG003 SLL (−7.6) Mutational NM_002466 MYBL2 v-myb myeloblastosis Ig mutation Low in Status viral oncogene indicator: Low in Mutated (CLL) homolog (avian)-like 2 mut CLL vs. NM_005214 CTLA4 cytotoxic T- CLL signature vs. High in DLBCL lymphocyte-associated DLBCL CLL protein 4 CLL vs. NM_000075 CDK4 cyclin-dependent MCL, CLL High in MCL kinase 4 Signature&CLL CLL Vs. MCL Distinguisher CLL vs. NM_004064 CDKN1B cyclin-dependent MCL, CLL High in MCL kinase inhibitor 1B Signature&CLL CLL (p27, Kip1) Vs. MCL Distinguisher CLL vs. NM_004454 ETV5 ets variant gene 5 (ets- RT-PCR analysis High in MCL related molecule) shows up CLL regulation in CLL CLL vs. NM_002467 MYC v-myc RT-PCR analysis High in MCL myelocytomatosis viral shows up CLL oncogene homolog regulation in CLL (avian) Mutational NM_005100 AKAP12 A kinase (PRKA) Ig mutation Low in Status anchor protein (gravin) indicator: Low in Mutated (CLL) 12 mut CLL vs. NM_032663 USP30 ubiquitin specific CLL signature vs. High in DLBCL protease 30 DLBCL CLL Mutational NM_001826 CKS1B CDC28 protein kinase Ig mutation Low in Status regulatory subunit 1B indicator: Low in Mutated (CLL) mut CLL vs. NM_006472 TXNIP thioredoxin interacting Resting B-cell High in DLBCL protein signature CLL Mutational NM_006187 OAS3 2′-5′-oligoadenylate Ig mutation Low in Status synthetase 3, 100 kDa indicator: Low in Mutated (CLL) mut CLL/SLL NM_002933 RNASE1 ribonuclease, RNase A down in vs MCL family, 1 (pancreatic) MCL vs SLL (−5.4) CLL/SLL NM_006820 C1orf29 chromosome 1 open down in vs FL reading frame 29 FL vs MCL (−4.3) CLL/SLL BC046632 FLJ21195 protein related to DAN up in FL vs FL and cerberus vs SLL (4.1) CLL/SLL NM_024713 FLJ22557 hypothetical protein up in FLJ22557 SLL (11.9) CLL/SLL NM_031305 ARHGAP24 Rho GTPase activating up in protein 24 SLL (4.4) Mutational NM_017935 BANK1 B-cell scaffold protein Ig mutation High in Status with ankyrin repeats 1 indicator: high in Mutated (CLL) mut CLL vs. XM_034274 MYBL1 v-myb myeloblastosis High in G-center Low in DLBCL viral oncogene type DLBCL CLL; homolog (avian)-like 1 High in G-center DLBCL CLL/SLL NM_014686 KIAA0355 KIAA0355 down in vs FL FL vs SLL (−4.5 ) CLL vs. NM_058176 HDAC9 histone deacetylase 9 CLL signature vs. High in DLBCL DLBCL CLL CLL vs. NM_006850 IL24 interleukin 24 Resting B-cell High in DLBCL signature CLL CLL vs. NM_000417 IL2RA interleukin 2 receptor, CLL signature vs. High in DLBCL aHCPha DLBCL CLL CLL vs. NM_000418 IL4R interleukin 4 receptor Resting B-cell High in DLBCL signature CLL CLL vs. NM_005574 LMO2 LIM domain only 2 High in G-center Low in DLBCL (rhombotin-like 1) type DLBCL CLL; High in G-center DLBCL CLL vs. NM_001760 CCND3 cyclin D3 CLL Vs. MCL High in MCL Distinguisher CLL CLL vs. NM_007289 MME membrane metallo- High in G-center Low in DLBCL endopeptidase (neutral type DLBCL CLL; endopeptidase, High in enkephalinase, G-center CALLA, CD10) DLBCL CLL vs. NM_006495 EVI2B ecotropic viral Resting B-cell High in DLBCL integration site 2B signature CLL CLL vs. NM_002738 PRKCB1 protein kinase C, beta 1 Resting B-cell High in DLBCL signature CLL CLL vs. NM_002835 PTPN12 protein tyrosine CLL signature vs. High in DLBCL phosphatase, non- DLBCL CLL receptor type 12 CLL vs. NM_002927 RGS13 regulator of G-protein High in G-center Low in DLBCL signalling 13 type DLBCL CLL; High in G-center DLBCL CLL vs. NM_003005 SEHCP selectin P (granule CLL signature vs. High in DLBCL membrane protein DLBCL CLL 140 kDa, antigen CD62) CLL vs. NM_005449 TOSO regulator of Fas- Resting B-cell High in DLBCL induced apoptosis signature CLL CLL vs. NM_133378 TTN titin CLL signature vs. High in DLBCL DLBCL CLL CLL vs. XM_042066 MAP3K1 mitogen-activated Resting B-cell High in DLBCL protein kinase kinase signature CLL kinase 1

TABLE 6 An HCP set specific for DLBCL, according to one embodiment of the invention Feature Accession Symbol Name Notes Level CLL vs. XM_042066 MAP3K1 mitogen-activated Resting B-cell High in CLL DLBCL protein kinase kinase signature kinase 1 DLBCL Vs. NM_006472 TXNIP thioredoxin interacting Genes Down in FL protein specific to DLBCL, Up in either FL DLBCL or FL CLL vs. NM_003005 SEHCP selectin P (granule CLL High in CLL DLBCL membrane protein signature vs. 140 kDa, antigen CD62) DLBCL CLL vs. NM_002927 RGS13 regulator of G-protein High in G- Low in CLL; DLBCL signalling 13 center type High in G- DLBCL center DLBCL CLL vs. NM_002835 PTPN12 protein tyrosine CLL High in CLL DLBCL phosphatase, non- signature vs. receptor type 12 DLBCL CLL vs. NM_002738 PRKCB1 protein kinase C, beta 1 Resting B-cell High in CLL DLBCL signature CLL vs. NM_133378 TTN titin CLL High in CLL DLBCL signature vs. DLBCL CLL vs. NM_007289 MME membrane metallo- High in G- Low in CLL; DLBCL endopeptidase (neutral center type High in G- endopeptidase, DLBCL center DLBCL enkephalinase, CALLA, CD10) CLL vs. NM_006472 TXNIP thioredoxin interacting Resting B-cell High in CLL DLBCL protein signature CLL vs. NM_005574 LMO2 LIM domain only 2 High in G- Low in CLL; DLBCL (rhombotin-like 1) center type High in G- DLBCL center DLBCL CLL vs. NM_000418 IL4R interleukin 4 receptor Resting B-cell High in CLL DLBCL signature CLL vs. NM_000417 IL2RA interleukin 2 receptor, CLL High in CLL DLBCL aHCPha signature vs. DLBCL CLL vs. NM_006850 IL24 interleukin 24 Resting B-cell High in CLL DLBCL signature CLL vs. NM_058176 HDAC9 histone deacetylase 9 CLL High in CLL DLBCL signature vs. DLBCL CLL vs. NM_005248 FGR Gardner-Rasheed feline Resting B-cell High in CLL DLBCL sarcoma viral (v-fgr) signature oncogene homolog CLL vs. XM_034274 MYBL1 v-myb myeloblastosis High in G- Low in CLL; DLBCL viral oncogene homolog center type High in G- (avian)-like 1 DLBCL center DLBCL DLBCL Vs. NM_006152 LRMP lymphoid-restricted Shipp and High in FL; BCL6 membrane protein Alizadeh DLBCL; ? Translocation Common Partners Genes; Akasaka: Translocation partner of BCL6 but exp data not shown CLL vs. NM_000633 BCL2 B-cell CLL/lymphoma 2 CLL High in CLL DLBCL signature vs. DLBCL DLBCL Vs. NM_005582 LY64 lymphocyte antigen 64 Genes Down in FL homolog, radioprotective specific to DLBCL, Up in 105 kDa (mouse) either FL DLBCL or FL DLBCL Vs. NM_006851 GLIPR1 GLI pathogenesis-related Genes Down in FL 1 (glioma) specific to DLBCL, Up in either FL DLBCL or FL DLBCL Vs. NM_001891 CSN2 casein beta Genes Down in FL specific to DLBCL, Up in either FL DLBCL or FL DLBCL Vs. NM_001781 CD69 CD69 antigen (p60, Genes Down in FL early T-cell activation specific to DLBCL, Up in antigen) either FL DLBCL or FL CLL vs. NM_005449 TOSO regulator of Fas-induced Resting B-cell High in CLL DLBCL apoptosis signature DLBCL Vs. NM_012203 GRHPR glyoxylate Expression in Up in FL; BCL6 reductase/hydroxypyruvate FL to DLBCL transformation Translocation reductase transformation; from FL to Partners Translocation DLBCL partner of BCL6 but exp data not shown CLL vs. NM_014207 CD5 CD5 antigen (p56-62) Hs.58685 High in CLL DLBCL DLBCL Vs. NM_004310 ARHH ras homolog gene Genes Down in FL; BCL6 family, member H specific to DLBCL, Up in Translocation either FL; ? Partners DLBCL or FL; Shipp and Alizadeh Common Genes; Akasaka: Translocation partner of BCL6 but exp data not shown DLBCL Vs. NM_002266 KPNA2 karyopherin aHCPha 2 Genes Up in FL (RAG cohort 1, importin specific to transformation aHCPha 1) either from FL to DLBCL or DLBCL FL; Expression in FL to DLBCL transformation DLBCL Vs. NM_007146 ZNF161 zinc finger protein 161 Expression in Up in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_002228 JUN v-jun sarcoma virus 17 Expression in Up in FL FL oncogene homolog Fl vs. GC (avian) DLBCL FL vs. NM_000633 BCL2 B-cell CLL/lymphoma 2 Genes High in FL; Burkitts; significantly Up in FL DLBCL Vs. deregulated; FL Genes up regulated in FL; Prognostically significant CLL vs. NM_032663 USP30 ubiquitin specific CLL High in CLL DLBCL protease 30 signature vs. DLBCL DLBCL Vs. NM_002046 GAPD glyceraldehyde-3- Genes Up in FL phosphate Correlated transformation dehydrogenase with Survival; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_001197 BIK BCL2-interacting killer Expression in Down in FL FL (apoptosis-inducing) Fl vs. GC DLBCL DLBCL Vs. NM_002168 IDH2 isocitrate dehydrogenase Genes Up in DLBCL; FL 2 (NADP+), specific to Down in FL; mitochondrial either Up in DLBCL or transformation FL; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_004044 ATIC 5-aminoimidazole-4- Genes Up in DLBCL; FL carboxamide specific to Down in FL; ribonucleotide either Up in formyltransferase/IMP DLBCL or transformation cyclohydrolase FL; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_003403 YY1 YY1 transcription factor Expression in Down in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_002910 RENBP renin binding protein Expression in Down in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_000852 GSTP1 glutathione S-transferase Expression in Down in FL FL pi Fl vs. GC DLBCL CLL vs. NM_006495 EVI2B ecotropic viral Resting B-cell High in CLL DLBCL integration site 2B signature DLBCL Vs. NM_033306 CASP4 caspase 4, apoptosis- Expression in Down in FL FL related cysteine protease Fl vs. GC DLBCL DLBCL Vs. NM_006636 MTHFD2 methylene Genes Up in DLBCL; FL tetrahydrofolate specific to Down in FL; dehydrogenase (NAD+ either Up in dependent), DLBCL or transformation methenyltetrahydrofolate FL; from FL to cyclohydrolase Expression in DLBCL FL to DLBCL transformation FL vs. NM_002086 GRB2 growth factor receptor- Genes High in FL; Burkitts; bound protein 2 significantly Up in FL DLBCL Vs. deregulated FL DLBCL Vs. NM_058197 CDKN2A cyclin-dependent kinase Expression in Up in FL FL; inhibitor 2A (melanoma, Fl vs. GC Deletions p16, inhibits CDK4) DLBCL associated with FL DLBCL Vs. NM_002574 PRDX1 peroxiredoxin 1 Genes Up in DLBCL; FL specific to Down in FL either DLBCL or FL DLBCL Vs. NM_031966 CCNB1 cyclin B1 Genes Up in DLBCL; FL specific to Down in FL either DLBCL or FL DLBCL Vs. NM_002467 MYC v-myc myelocytomatosis Signature Uncertain in FL viral oncogene homolog genes Common (avian) common to Genes; Down both Shipp in and Alizadeh transformation from FL to DLBCL; Up in FL CLL vs. NM_001775 CD38 CD38 antigen (p45) Hs.174944; Low in CLL; DLBCL Prognostically High in G- significant center DLBCL DLBCL Vs. NM_004907 ETR101 immediate early protein Expression in Down in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_000418 IL4R interleukin 4 receptor Expression in Up in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_001344 DAD1 defender against cell Expression in Down in FL FL death 1 Fl vs. GC DLBCL CLL vs. NM_016187 BIN2 bridging integrator 2 Resting B-cell High in CLL DLBCL signature CLL vs. NM_001197 BIK BCL2-interacting killer High in G- Low in CLL; DLBCL (apoptosis-inducing) center type High in G- DLBCL center DLBCL CLL vs. NM_001706 BCL6 B-cell CLL/lymphoma 6 High in G- Low in CLL; DLBCL (zinc finger protein 51) center type High in G- DLBCL center DLBCL CLL vs. NM_000698 ALOX5 arachidonate 5- Resting B-cell High in CLL DLBCL lipoxygenase signature CLL vs. NM_002390 ADAM11 a disintegrin and Resting B-cell High in CLL DLBCL metalloproteinase signature domain 11 DLBCL Vs. NM_000884 IMPDH2 IMP (inosine Genes Up in DLBCL; FL monophosphate) specific to Down in FL; dehydrogenase 2 either Up in DLBCL or transformation FL; from FL to Expression in DLBCL FL tp DLBCL transformation DLBCL Vs. NM_002511 NMBR neuromedin B receptor Expression in Up in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_005566 LDHA lactate dehydrogenase A Genes Up in DLBCL; FL specific to Down in FL; either Up in DLBCL or transformation FL; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_002166 ID2 inhibitor of DNA Expression in Up in FL FL binding 2, dominant Fl vs. GC negative helix-loop-helix DLBCL protein DLBCL Vs. NM_005526 HSF1 heat shock transcription Expression in Up in FL FL factor 1 Fl vs. GC DLBCL DLBCL Vs. NM_001901 CTGF connective tissue growth Expression in Up in FL FL factor Fl vs. GC DLBCL DLBCL Vs. NM_000365 TPI1 triosephosphate Genes Up in DLBCL; FL isomerase 1 specific to Down in FL; either Up in DLBCL or transformation FL; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_000269 NME1 non-metastatic cells 1, Genes Up in DLBCL; FL protein (NM23A) specific to Down in FL; expressed in either Up in DLBCL or transformation FL; from FL to Expression in DLBCL FL to DLBCL transformation CLL vs. NM_005214 CTLA4 cytotoxic T-lymphocyte- CLL High in CLL DLBCL associated protein 4 signature vs. DLBCL DLBCL Vs. NM_003070 SMARCA2 SWI/SNF related, matrix Expression in Up in FL FL associated, actin Fl vs. GC dependent regulator of DLBCL chromatin, subfamily a, member 2 ABC VS NM_002648 PIM1 pim-1 oncogene Wright Low in GC GC predictor; DLBCL; Up in DLBCL; Expression in Transformation DLBCL Vs. FL to DLBCL FL transformation DLBCL Vs. NM_021643 TRB2 tribbles homolog 2 Genes Down in FL specific to DLBCL, Up in either FL DLBCL or FL Survival; NM_021603 FXYD2 FXYD domain Genes Up in cured; DLBCL Vs. containing ion transport Correlated Down in fatal; FL regulator 2 with Survival; Up in Expression in Transformed FL to DLBCL DLBCL transformation DLBCL Vs. NM_004619 TRAF5 TNF receptor-associated Genes Down in FL; MLBCL factor 5 specific to DLBCL, Up in vs. DLBCL either FL; Low in DLBCL or MLBCL FL DLBCL Vs. NM_005998 CCT3 chaperonin containing Genes Up in DLBCL; FL TCP1, subunit 3 specific to Down in FL; (gamma) either Up in DLBCL or Transformation FL; Expression in FL to DLBCL transformation DLBCL Vs. NM_000034 ALDOA aldolase A, fructose- Genes Up in DLBCL; FL bisphosphate specific to Down in FL; either Up in DLBCL or Transformation FL; Expression in FL to DLBCL transformation DLBCL vs. NM_019841 TRPV5 transient receptor Strong Down in MCL; potential cation channel, Classifier DLBCL; Up in CD5+/− subfamily V, member 5 Separating MCL; Down DLBCL MCLs and in CD5+; Up DLBCLs and in CD5− CD5+ from CD5− DLBCLs DLBCL Vs. NM_002162 ICAM3 intercellular adhesion Expression in Down in FL; DLBCL molecule 3 FL to DLBCL Transformed vs. MCL transformation; DLBCL; Strong Down in Classifier DLBCL; Up in Separating MCL MCLs and DLBCLs DLBCL Vs. NM_001901 CTGF connective tissue growth Expression in Down in FL factor FL to DLBCL Transformed transformation DLBCL ABC VS NM_004630 SF1 splicing factor 1 Signature Uncertain in GC DLBCL genes Common common to Genes both Shipp and Alizadeh ABC VS NM_000418 IL4R interleukin 4 receptor Signature Uncertain in GC DLBCL genes Common common to Genes both Shipp and Alizadeh ABC VS NM_001882 CRHBP corticotropin releasing Signature Uncertain in GC DLBCL hormone binding protein genes Common common to Genes both Shipp and Alizadeh ABC VS NM_001775 CD38 CD38 antigen (p45) Signature Uncertain in GC DLBCL genes Common common to Genes both Shipp and Alizadeh ABC VS NM_003656 CAMK1 calcium/calmodulin- Signature Uncertain in GC DLBCL dependent protein kinase I genes Common common to Genes both Shipp and Alizadeh Survival; NM_002046 GAPD glyceraldehyde-3- Genes Down in DLBCL Vs. phosphate Correlated Cured; Up in FL dehydrogenase with Survival; Fatal; Up in Expression in Transformed FL to DLBCL DLBCL transformation DLBCL Vs. NM_000598 IGFBP3 insulin-like growth Expression in Down in FL factor binding protein 3 FL to DLBCL Transformed transformation DLBCL MLBCL vs. NM_002447 MST1R macrophage stimulating MLBCL vs High in DLBCL 1 receptor (c-met-related DLBCL MLBCL tyrosine kinase) signature DLBCL vs. NM_156039 CSF3R colony stimulating factor Strong Down in MCL 3 receptor (granulocyte) Classifier DLBCL; Up in Separating MCL MCLs and DLBCLs DLBCL vs. NM_181430 ILF1 interleukin enhancer Strong Down in MCL binding factor 1 Classifier DLBCL; Up in Separating MCL MCLs and DLBCLs DLBCL vs. NM_004475 FLOT2 flotillin 2 Strong Down in MCL Classifier DLBCL; Up in Separating MCL MCLs and DLBCLs DLBCL vs. NM_004941 DHX8 DEAH (Asp-Glu-Ala- Strong Down in MCL His) box polypeptide 8 Classifier DLBCL; Up in Separating MCL MCLs and DLBCLs DLBCL vs. NM_053056 CCND1 cyclin D1 (PRAD1: Strong Down in MCL parathyroid Classifier DLBCL; Up in adenomatosis 1) Separating MCL MCLs and DLBCLs x (DLBCL) NM_002738 PRKCB1 protein kinase C, beta 1 Genes Down in Correlated Cured; Up in with Survival; Fatal; Low in MLBCL vs. MLBCL DLBCL Survival NM_058197 CDKN2A cyclin-dependent kinase Genes Down in (DLBCL) inhibitor 2A (melanoma, Correlated Cured; Up in p16, inhibits CDK4) with Survival Fatal ABC VS BC011857 IGHM immunoglobulin heavy Wright Low in GC GC constant mu predictor; DLBCL; Low DLBCL; Expression in in MLBCL; MLBCL vs. FL to DLBCL Down in DLBCL; transformation Transformed DLBCL Vs. DLBCL FL MLBCL vs. NM_004972 JAK2 Janus kinase 2 (a protein MLBCL vs High in DLBCL tyrosine kinase) DLBCL MLBCL signature MLBCL vs. NM_006889 CD86 CD86 antigen (CD28 MLBCL vs High in DLBCL antigen ligand 2, B7-2 DLBCL MLBCL antigen) signature MLBCL vs. NM_001715 BLK B lymphoid tyrosine MLBCL vs Low in DLBCL kinase DLBCL MLBCL signature DLBCL Vs. NM_012203 GRHPR glyoxylate Expression in Up in FL reductase/hydroxypyruvate FL to DLBCL Transformation reductase transformation DLBCL Vs. NM_003070 SMARCA 2 SWI/SNF related, matrix Expression in Down in FL associated, actin FL to DLBCL Transformed dependent regulator of transformation DLBCL chromatin, subfamily a, member 2 DLBCL Vs. NM_004907 ETR101 immediate early protein Expression in Down in FL FL to DLBCL Transformed transformation DLBCL DLBCL vs. NM_134269 SMTN smoothelin Strong Down in MCL Classifier DLBCL; Up in Separating MCL MCLs and DLBCLs DLBCL Vs. NM_000405 GM2A GM2 ganglioside Genes Up in DLBCL; FL activator protein specific to Down in FL either DLBCL or FL ABC VS NM_002460 IRF4 interferon regulatory Wright Low in GC GC factor 4, MUM1 predictor; DLBCL; DLBCL; Signature Uncertain in DLBCL Vs. genes Common FL common to Genesin both Shipp Common and Alizadeh; Genes; Up in Expression in Transformed FL to DLBCL DLBCL transformation ABC VS NM_002467 MYC v-myc myelocytomatosis Signature Uncertain in GC viral oncogene homolog genes Common DLBCL; (avian) common to Genes; Down DLBCL Vs. both Shipp in Cured; Up FL and Alizadeh; in Fatal; Down Rosenwald in Survival Transformation; Predictor Up in Genes Transformed DLBCL, de Vos DLBCL Vs. NM_006325 RAN RAN, member RAS Expression in Up in FL oncogene family FL to DLBCL transformation transformation from FL to DLBCL DLBCL Vs. NM_002129 HMGB2 high-mobility group box 2 Expression in Up in FL FL to DLBCL transformation transformation from FL to DLBCL DLBCL Vs. NM_005340 HINT1 histidine triad nucleotide Expression in Up in FL binding protein 1 FL to DLBCL transformation transformation from FL to DLBCL DLBCL Vs. NM_006472 TXNIP thioredoxin interacting Genes Down in FL protein specific to DLBCL, Up in either FL; Down in DLBCL or Transformed FL; DLBCL Expression in FL to DLBCL transformation DLBCL Vs. NM_001783 CD79A CD79A antigen Expression in Up in FL (immunoglobulin- FL to DLBCL transformation associated aHCPha) transformation from FL to DLBCL ABC VS NM_001706 BCL6 B-cell CLL/lymphoma 6 Wright High in GC GC DLBCL (zinc finger protein 51) predictor; DLBCL; Signature Uncertain in genes Common common to Genesin both Shipp Common and Alizadeh; Genes; Up in Rosenwald cured; Down Survival in fatal Predictor Genes DLBCL Vs. NM_002648 PIM1 pim-1 oncogene Wright Low in GC FL predictor; DLBCL; Up in Expression in transformation FL to DLBCL from FL to transformation DLBCL DLBCL Vs. NM_021960 Mcl-1 myeloid cell leukemia Genes up High in FL FL sequence 1 (BCL2- regulated in related) (MCL1) FL DLBCL Vs. NM_002838 PTPRC protein tyrosine Expression in Down in FL phosphatase, receptor FL to DLBCL transformation type, C transformation from FL to DLBCL DLBCL Vs. NM_152866 MS4A1 membrane-spanning 4- Expression in Down in FL domains, subfamily A, FL to DLBCL transformation member 1 transformation from FL to DLBCL DLBCL Vs. NM_006495 EVI2B ecotropic viral Expression in Down in FL integration site 2B FL to DLBCL transformation transformation from FL to DLBCL DLBCL Vs. NM_001647 APOD apolipoprotein D Expression in Down in FL FL to DLBCL transformation transformation from FL to DLBCL DLBCL Vs. NM_000626 CD79B CD79B antigen Expression in Up in FL (immunoglobulin- FL to DLBCL transformation associated beta) transformation from FL to DLBCL ABC VS NM_001092 ABR active BCR-related gene Signature Uncertain in GC genes Common DLBCL; common to Genes; Down DLBCL vs. both Shipp in DLBCL; Up MCL and Alizadeh; in MCL Strong Classifier Separating MCLs and DLBCLs DLBCL vs. NM_000277 PAH phenylalanine Strong Down in MCL hydroxylase Classifier DLBCL; Up in Separating MCL MCLs and DLBCLs ABC VS NM_000698 ALOX5 arachidonate 5- Signature Uncertain in GC lipoxygenase genes Common DLBCL; common to Genes; Down DLBCL Vs. both Shipp in FL and Alizadeh; Transformed Expression in DLBCL FL to DLBCL transformation ABC VS XM_034274 MYBL1 v-myb myeloblastosis Wright High in GC GC DLBCL viral oncogene homolog predictor; DLBCL; (avian)-like 1 Signature Uncertain in genes Common common to Genesin both Shipp Common and Alizadeh Genes ABC VS NM_006152 LRMP lymphoid-restricted Wright High in GC GC DLBCL membrane protein predictor; DLBCL; Signature Uncertain in genes Common common to Genesin both Shipp Common and Alizadeh Genes ABC VS NM_005574 LMO2 LIM domain only 2 Wright High in GC GC DLBCL (rhombotin-like 1) predictor; DLBCL; Signature Uncertain in genes Common common to Genesin both Shipp Common and Alizadeh Genes ABC VS NM_001987 ETV6 ets variant gene 6 (TEL Wright Low in GC GC DLBCL oncogene) predictor; DLBCL; Signature Uncertain in genes Common common to Genesin both Shipp Common and Alizadeh Genes ABC VS NM_001242 TNTFRSF7 tumor necrosis factor Signature Uncertain in GC receptor superfamily, genes Common DLBCL; member 7 common to Genes; Low in MLBCL vs. both Shipp MLBCL; DLBCL; and Alizadeh; Down in DLBCL Vs. MLBCL vs. Transformed FL DLBCL; DLBCL Expression in FL to DLBCL transformation ABC VS NM_002166 ID2 inhibitor of DNA Signature Uncertain in GC DLBCL binding 2, dominant genes Common negative helix-loop-helix common to Genes; Up in protein both Shipp CD5+; Down and Alizadeh; in CD5− Strong Classifier Genes Separating CD5+ from CD5− DLBCLs ABC VS NM_000633 BCL2 B-cell CLL/lymphoma 2 Signature Uncertain in GC genes Common DLBCL; common to Genes; Down DLBCL Vs. both Shipp in FL and Alizadeh Transformed DLBCL MLBCL vs. NM_003254 TIMP1 tissue inhibitor of MLBCL vs High in DLBCL metalloproteinase 1 DLBCL MLBCL (erythroid potentiating signature activity, collagenase inhibitor) DLBCL Vs. NM_006184 NUCB1 nucleobindin 1 Expression in Up in FL FL to DLBCL Transformed transformation DLBCL ABC VS NM_007289 MME membrane metallo- Wright High in GC GC endopeptidase (neutral predictor; DLBCL; DLBCL; endopeptidase, Signature Uncertain in MLBCL vs. enkephalinase, CALLA, genes Common DLBCL CD10) common to Genes; Up in both Shipp cured; Down and Alizadeh; in fatal; Low MLBCL vs. in MLBCL DLBCL signature ABC VS NM_004513 IL16 interleukin 16 Wright Low in GC GC (lymphocyte predictor; DLBCL; DLBCL; chemoattractant factor) Signature Uncertain in MLBCL vs. genes Common DLBCL common to Genes; Low in both Shipp MLBCL and Alizadeh; MLBCL vs. DLBCL signature ABC VS NM_001877 CR2 complement component Signature Uncertain in GC (3d/Epstein Barr virus) genes Common DLBCL; receptor 2 common to Genes; Down DLBCL Vs. both Shipp in FL and Alizadeh; Transformed Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_001831 CLU clusterin (complement Genes Down in FL lysis inhibitor, SP-40,40, specific to DLBCL, Up in sulfated glycoprotein 2, either FL; Down in testosterone-repressed DLBCL or Transformed prostate message 2, FL; DLBCL apolipoprotein J) Expression in FL to DLBCL transformation ABC VS NM_001923 DDB1 damage-specific DNA Wright Low in GC GC DLBCL binding protein 1, predictor; DLBCL; 127 kDa Signature Uncertain in genes Common common to Genesin both Shipp Common and Alizadeh Genes

TABLE 7 An HCP set specific for FL, according to one embodiment of the invention Feature Accession Symbol Name Notes Level FL BC011857 IGHM immunoglobulin heavy Down in FL (−6.6) constant mu FL; MCL NM_000424 KRT5 keratin 5 (epidermolysis down in FL (−5.3); bullosa simplex, down in Dowling- MCL (−4) Meara/Kobner/Weber- Cockayne types) FL vs MCL AB037771 USP53 ubiquitin specific up in FL vs protease 53 MCL (4.2) FL vs NM_025113 C13orf18 chromosome 13 open down in FL vs CLL/SLL reading frame 18 SLL (−5.3) FL vs MCL NM_000418 IL4R interleukin 4 receptor up in FL vs MCL (5.4) FL vs MCL NM_001781 CD69 CD69 antigen (p60, down in FL vs early T-cell activation MCL (−4.1) antigen) FL NM_002984 CCL4 chemokine (C-C motif) down in FL (−5.6) ligand 4 FL vs MCL NM_000405 GM2A GM2 ganglioside down in FL vs activator MCL (−4.4) FL vs MCL NM_002228 JUN v-jun sarcoma virus 17 down in FL vs oncogene homolog MCL (−4.6) (avian) FL NM_006850 IL24 interleukin 24 down in FL (−8.1) FL vs MCL NM_006475 POSTN periostin, osteoblast Up in FL vs specific factor MCL (4) FL vs SLL NM_031942 CDCA7 cell division cycle Up in FL vs associated 7 SLL (8.8) FL vs MCL NM_001640 APEH N-acylaminoacyl-peptide down in MCL hydrolase (−6.5); up in FL vs MCL (6) FL vs MCL NM_018842 LOC55971 insulin receptor tyrosine down in FL vs kinase substrate MCL (−8.4) FL NM_147180 PPP3R2 protein phosphatase 3 down in FL (−4.4) (formerly 2B), regulatory subunit B, 19 kDa, beta isoform (calcineurin B, type II) FL NM_002276 KRT19 keratin 19 down in FL (−5) FL NM_001675 ATF4 activating transcription up in FL (4.4) factor 4 (tax-responsive enhancer element B67) FL vs MCL NM_021813 BACH2 BTB and CNC up in FL vs homology 1, basic MCL (5.5) leucine zipper transcription factor 2 FL NM_006565 CTCF CCCTC-binding factor up in FL vs (zinc finger protein) MCL (9.3); up in FL vs SLL (10.2) FL NM_005537 ING1 inhibitor of growth up in FL (4.5) family, member 1 FL vs MCL NM_006164 NFE2L2 nuclear factor (erythroid- up in FL vs derived 2)-like 2 MCL (4.1) FL NM_004630 SF1 splicing factor 1 down in FL (−4.2) CLL/SLL vs NM_019846 CCL28 chemokine (C-C motif) up in FL vs FL ligand 28 CLL/SLL (5.2) FL vs MCL NM_006889 CD86 CD86 antigen (CD28 up in FL vs antigen ligand 2, B7-2 MCL (7.9) antigen) FL NM_032738 FREB Fc receptor homolog up in FL (4.8) expressed in B cells FL BC019046 IGHG1 immunoglobulin heavy down in FL (−6.6) constant gamma 1 (G1m marker) FL NM_002189 IL15RA interleukin 15 receptor, down in FL (−4.1) aHCPha FL NM_004827 ABCG2 ATP-binding cassette, down in FL (−8.4) sub-family G (WHITE), member 2 FLL NM_001647 APOD apolipoprotein D down in FL vs MCL (−8.3); down in FL vs CLL/SLL (−5.8) DLBCL Vs. NM_002467 MYC v-myc myelocytomatosis Signature Uncertain in FL viral oncogene homolog genes Common (avain) common to Genes; Down both Shipp in and Alizadeh transformation from FL to DLBCL; Up in FL DLBCL Vs. NM_031966 CCNB1 cyclin B1 Genes Up in DLBCL; FL specific to Down in FL either DLBCL or FL DLBCL Vs. NM_002574 PRDX1 peroxiredoxin 1 Genes Up in DLBCL; FL specific to Down in FL either DLBCL or FL DLBCL Vs. NM_058197 CDKN2A cyclin-dependent kinase Expression in Up in FL FL; inhibitor 2A (melanoma, Fl vs. GC Deletions p16, inhibits CDK4) DLBCL associated with FL FL vs. NM_002086 GRB2 growth factor receptor- Genes High in FL; Burkitts; bound protein 2 significantly Up in FL DLBCL Vs. deregulated FL DLBCL Vs. NM_001197 BIK BCL2-interacting killer Expression in Down in FL FL (apoptosis-inducing) Fl vs. GC DLBCL DLBCL Vs. NM_033306 CASP4 caspase 4, apoptosis- Expression in Down in FL FL related cysteine protease Fl vs. GC DLBCL DLBCL Vs. NM_004907 ETR101 immediate early protein Expression in Down in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_000852 GSTP1 glutathione S-transferase Expression in Down in FL FL pi Fl vs. GC DLBCL DLBCL Vs. NM_002910 RENBP renin binding protein Expression in Down in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_003403 YY1 YY1 transcription factor Expression in Down in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_004044 ATIC 5-aminoimidazole-4- Genes Up in DLBCL; FL carboxamide specific to Down in FL; ribonucleotide either Up in formyltransferase/IMP DLBCL or transformation cyclohydrolase FL; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_002168 IDH2 isocitrate dehydrogenase Genes Up in DLBCL; FL 2 (NADP+), specific to Down in FL; mitochondrial either Up in DLBCL or transformation FL; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_000884 IMPDH2 IMP (inosine Genes Up in DLBCL; FL monophosphate) specific to Down in FL; dehydrogenase 2 either Up in DLBCL or transformation FL; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_005566 LDHA lactate dehydrogenase A Genes Up in DLBCL; FL specific to Down in FL; either Up in DLBCL or transformation FL; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_006636 MTHFD2 methylene Genes Up in DLBCL; FL tetrahydrofolate specific to Down in FL; dehydrogenase (NAD+ either Up in dependent), DLBCL or transformation methenyltetrahydrofolate FL; from FL to cyclohydrolase Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_000269 NME1 non-metastatic cells 1, Genes Up in DLBCL; FL protein (NM23A) specific to Down in FL; expressed in either Up in DLBCL or transformation FL; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_000365 TPI1 triosephosphate Genes Up in DLBCL; FL isomerase 1 specific to Down in FL; either Up in DLBCL or transformation FL; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_001901 CTGF connective tissue growth Expression in Up in FL FL factor Fl vs. GC DLBCL DLBCL Vs. NM_005526 HSF1 heat shock transcription Expression in Up in FL FL factor 1 Fl vs. GC DLBCL DLBCL Vs. NM_002166 ID2 inhibitor of DNA Expression in Up in FL FL binding 2, dominant Fl vs. GC negative helix-loop-helix DLBCL protein DLBCL Vs. NM_000418 IL4R interleukin 4 receptor Expression in Up in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_002511 NMBR neuromedin B receptor Expression in Up in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_003070 SMARCA2 SWI/SNF related, matrix Expression in Up in FL FL associated, actin Fl vs. GC dependent regulator of DLBCL chromatin, subfamily a, member 2 FL vs. NM_000633 BCL2 B-cell CLL/lymphoma 2 Genes High in FL; Burkitts; significantly Up in FL DLBCL Vs. deregulated; FL Genes up regulated in FL; Prognostically significant DLBCL Vs. NM_002228 JUN v-jun sarcoma virus 17 Expression in Up in FL FL oncogene homolog Fl vs. GC (avian) DLBCL DLBCL Vs. NM_007146 ZNF161 zinc finger protein 161 Expression in Up in FL FL Fl vs. GC DLBCL DLBCL Vs. NM_002266 KPNA2 karyopherin aHCPha 2 Genes Up in FL (RAG cohort 1, importin specific to transformation aHCPha 1) either from FL to DLBCL or DLBCL FL; Expression in FL to DLBCL transformation DLBCL Vs. NM_004310 ARHH ras homolog gene Genes Down in FL; BCL6 family, member H specific to DLBCL, Up in Translocation either FL; ? Partners DLBCL or FL; Shipp and Alizadeh Common Genes; Akasaka: Translocation partner of BCL6 but exp data not shown DLBCL Vs. NM_006152 LRMP lymphoid-restricted Shipp and High in FL; BCL6 membrane protein Alizadeh DLBCL; ? Translocation Common Partners Genes; Akasaka: Translocation partner of BCL6 but exp data not shown DLBCL Vs. NM_012203 GRHPR glyoxylate Expression in Up in FL; BCL6 reductase/hydroxypyruvate FL to DLBCL transformation Translocation reductase transformation; from FL to Partners Translocation DLBCL partner of BCL6 but exp data not shown DLBCL Vs. NM_002046 GAPD glyceraldehyde-3- Genes Up in FL phosphate Correlated transformation dehydrogenase with Survival; from FL to Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_001781 CD69 CD69 antigen (p60, Genes Down in FL early T-cell activation specific to DLBCL, Up in antigen) either FL DLBCL or FL DLBCL Vs. NM_001891 CSN2 casein beta Genes Down in FL specific to DLBCL, Up in either FL DLBCL or FL FL NM_022829 SLC13A3 solute carrier family 13 up in FL (4.3) (sodium-dependent dicarboxylate transporter), member 3 DLBCL Vs. NM_006851 GLIPR1 GLI pathogenesis-related Genes Down in FL 1 (glioma) specific to DLBCL, Up in either FL DLBCL or FL DLBCL Vs. NM_005582 LY64 lymphocyte antigen 64 Genes Down in FL homolog, radioprotective specific to DLBCL, Up in 105 kDa (mouse) either FL DLBCL or FL DLBCL Vs. NM_021643 TRB2 tribbles homolog 2 Genes Down in FL specific to DLBCL, Up in either FL DLBCL or FL DLBCL Vs. NM_006472 TXNIP thioredoxin interacting Genes Down in FL protein specific to DLBCL, Up in either FL DLBCL or FL DLBCL Vs. NM_001344 DAD1 defender against cell Expression in Down in FL FL death 1 Fl vs. GC DLBCL DLBCL Vs. NM_001647 APOD apolipoprotein D Expression in Down in FL FL to DLBCL transformation transformation from FL to DLBCL DLBCL Vs. NM_006495 EVI2B ecotropic viral Expression in Down in FL integration site 2B FL to DLBCL transformation transformation from FL to DLBCL DLBCL Vs. NM_152866 MS4A1 membrane-spanning 4- Expression in Down in FL domains, subfamily A, FL to DLBCL transformation member 1 transformation from FL to DLBCL DLBCL Vs. NM_002838 PTPRC protein tyrosine Expression in Down in FL phosphatase, receptor FL to DLBCL transformation type, C transformation from FL to DLBCL DLBCL Vs. NM_021960 Mcl-1 myeloid cell leukemia Genes up High in FL FL sequence 1 (BCL2- regulated in related) (MCL1) FL DLBCL Vs. NM_002648 PIM1 pim-1 oncogene Wright Low in GC FL predictor; DLBCL; Up in Expression in transformation FL to DLBCL from FL to transformation DLBCL DLBCL Vs. NM_000405 GM2A GM2 ganglioside Genes Up in DLBCL; FL activator protein specific to Down in FL either DLBCL or FL DLBCL Vs. NM_001783 CD79A CD79A antigen Expression in Up in FL (immunoglobulin- FL to DLBCL transformation associated aHCPha) transformation from FL to DLBCL DLBCL Vs. NM_000626 CD79B CD79B antigen Expression in Up in FL (immunoglobulin- FL to DLBCL transformation associated beta) transformation from FL to DLBCL CLL/SL vs NM_006820 C1orf29 chromosome 1 open down in FL vs FL reading frame 29 MCL (−4.3) DLBCL Vs. NM_005340 HINT1 histidine triad nucleotide Expression in Up in FL binding protein 1 FL to DLBCL transformation transformation from FL to DLBCL DLBCL Vs. NM_002129 HMGB2 high-mobility group box 2 Expression in Up in FL FL to DLBCL transformation transformation from FL to DLBCL DLBCL Vs. NM_006325 RAN RAN, member RAS Expression in Up in FL oncogene family FL to DLBCL transformation transformation from FL to DLBCL FL vs. NM_000277 PAH phenylalanine Genes High in FL Burkitts hydroxylase significantly deregulated FL vs. NM_133480 TADA3L transcriptional adaptor 3 Genes High in FL Burkitts (NGG1 homolog, yeast)- significantly like deregulated FL vs. NM_003656 CAMK1 calcium/calmodulin- Genes High in FL Burkitts dependent protein kinase I significantly deregulated FL vs. NM_005248 FGR Gardner-Rasheed feline Genes Low in FL Burkitts sarcoma viral (v-fgr) significantly oncogene homolog deregulated FL vs. NM_002447 MST1R macrophage stimulating Genes Low in FL Burkitts 1 receptor (c-met-related significantly tyrosine kinase) deregulated FL vs. NM_003254 TIMP1 tissue inhibitor of Genes Low in FL Burkitts metalloproteinase 1 significantly (erythroid potentiating deregulated activity, collagenase inhibitor) ABC VS NM_002467 MYC v-myc myelocytomatosis Signature Uncertain in GC viral oncogene homolog genes Common DLBCL; (avian) common to Genes; Down DLBCL Vs. both Shipp in Cured; Up FL and Alizadeh; in Fatal; Down Rosenwald in Survival Transformation; Predictor Up in Genes Transformed DLBCL, de Vos ABC VS NM_002460 IRF4 interferon regulatory Wright Low in GC GC factor 4, MUM1 predictor; DLBCL; DLBCL; Signature Uncertain in DLBCL Vs. genes Common FL common to Genesin both Shipp Common and Alizadeh; Genes; Up in Expression in Transformed FL to DLBCL DLBCL transformation ABC VS NM_001242 TNFRSF7 tumor necrosis factor Signature Uncertain in GC receptor superfamily, genes Common DLBCL; member 7 common to Genes; Low in MLBCL vs. both Shipp MLBCL; DLBCL; and Alizadeh; Down in DLBCL Vs. MLBCL vs. Transformed FL DLBCL; DLBCL Expression in FL to DLBCL transformation ABC VS NM_000633 BCL2 B-cell CLL/lymphoma 2 Signature Uncertain in GC genes Common DLBCL; common to Genes; Down DLBCL Vs. both Shipp in FL and Alizadeh Transformed DLBCL ABC VS NM_001877 CR2 complement component Signature Uncertain in GC (3d/Epstein Barr virus) genes Common DLBCL; receptor 2 common to Genes; Down DLBCL Vs. both Shipp in FL and Alizadeh; Transformed Expression in DLBCL FL to DLBCL transformation DLBCL Vs. NM_006184 NUCB1 nucleobindin 1 Expression in Up in FL FL to DLBCL Transformed transformation DLBCL ABC VS NM_000698 ALOX5 arachidonate 5- Signature Uncertain in GC lipoxygenase genes Common DLBCL; common to Genes; Down DLBCL Vs. both Shipp in FL and Alizadeh; Transformed Expression in DLBCL FL to DLBCL transformation ABC VS BC011857 IGHM immunoglobulin heavy Wright Low in GC GC constant mu predictor; DLBCL; Low DLBCL; Expression in in MLBCL; MLBCL vs. FL to DLBCL Down in DLBCL; transformation Transformed DLBCL Vs. DLBCL FL DLBCL Vs. NM_001831 CLU clusterin (complement Genes Down in FL lysis inhibitor, SP-40,40, specific to DLBCL, Up in sulfated glycoprotein 2, either FL; Down in testosterone-repressed DLBCL or Transformed prostate message 2, FL; DLBCL apolipoprotein J) Expression in FL to DLBCL transformation DLBCL Vs. NM_006472 TXNIP thioredoxin interacting Genes Down in FL protein specific to DLBCL, Up in either FL; Down in DLBCL or Transformed FL; DLBCL Expression in FL to DLBCL transformation Survival; NM_002046 GAPD glyceraldehyde-3- Genes Down in DLBCL Vs. phosphate Correlated Cured; Up in FL dehydrogenase with Survival; Fatal; Up in Expression in Transformed FL to DLBCL DLBCL transformation ABC VS NM_002648 PIM1 pim-1 oncogene Wright Low in GC GC predictor; DLBCL; Up in DLBCL; Expression in Transformation DLBCL Vs. FL to DLBCL FL transformation DLBCL Vs. NM_002162 ICAM3 intercellular adhesion Expression in Down in FL; DLBCL molecule 3 FL to DLBCL Transformed vs. MCL transformation; DLBCL; Strong Down in Classifier DLBCL; Up in Separating MCL MCLs and DLBCLs DLBCL Vs. NM_000598 IGFBP3 insulin-like growth Expression in Down in FL factor binding protein 3 FL to DLBCL Transformed transformation DLBCL DLBCL Vs. NM_000034 ALDOA aldolase A, fructose- Genes Up in DLBCL; FL bisphosphate specific to Down in FL; either Up in DLBCL or Transformation FL; Expression in FL to DLBCL transformation DLBCL Vs. NM_005998 CCT3 chaperonin containing Genes Up in DLBCL; FL TCP1, subunit 3 specific to Down in FL; (gamma) either Up in DLBCL or Transformation FL; Expression in FL to DLBCL transformation FL vs MCL NM_024728 C7orf10 chromosome 7 open up in FL vs reading frame 10 MCL (4.5) CLL/SLL vs BC046632 FLJ21195 protein related to DAN up in FL vs FL and cerberus SLL (4.1) DLBCL Vs. NM_004619 TRAF5 TNF receptor-associated Genes Down in FL; MLBCL factor 5 specific to DLBCL, Up in vs. DLBCL either FL; Low in DLBCL or MLBCL FL Survival; NM_021603 FXYD2 FXYD domain Genes Up in cured; DLBCL Vs. containing ion transport Correlated Down in fatal; FL regulator 2 with Survival; Up in Expression in Transformed FL to DLBCL DLBCL transformation DLBCL Vs. NM_001901 CTGF connective tissue growth Expression in Down in FL factor FL to DLBCL Transformed transformation DLBCL FL NM_024713 FLJ22557 hypothetical protein up in FL (6.5) FLJ22557 DLBCL Vs. NM_004907 ETR101 immediate early protein Expression in Down in FL FL to DLBCL Transformed transformation DLBCL DLBCL Vs. NM_003070 SMARCA2 SWI/SNF related, matrix Expression in Down in FL associated, actin FL to DLBCL Transformed dependent regulator of transformation DLBCL chromatin, subfamily a, member 2 DLBCL Vs. NM_012203 GRHPR glyoxylate Expression in Up in FL reductase/hydroxypyruvate FL to DLBCL Transformation reductase transformation CLL/SLL vs NM_014686 KIAA0355 KIAA0355 down in FL vs FL SLL (−4.5) FL AB029034 PHF8 PHD finger protein 8 down in FL (−10.8) FL BC001077 LOC87769 hypothetical protein down in FL (−4.9) BC004360 FL NM_024319 C1orf35 chromosome 1 open down in FL (−4.4); reading frame 35 down in FL vs SLL (−5) FL vs MCL NM_015670 SENP3 SUMO1/sentrin/SMT3 up in FL vs specific protease 3 MCL

TABLE 8 An HCP set specific for HL, according to one embodiment of the invention Feature Accession Symbol Name Notes Level Survival NM_001618 ADPRT ADP-ribosyltransferase Genes with Down in Fatal; (HL) (NAD+; poly (ADP- prognostic Up in Cured ribose) polymerase) value Survival NM_000038 APC adenomatosis polyposis Genes with Down in Fatal; (HL) coli prognostic Up in Cured value Survival NM_001226 CASP6 caspase 6, apoptosis- Genes with Down in Fatal; (HL) related cysteine protease prognostic Up in Cured value Survival NM_001795 CDH5 cadherin 5, type 2, VE- Genes with Up in Fatal; (HL) cadherin (vascular prognostic Down in Cured epithelium) value Survival NM_058197 CDKN2A cyclin-dependent kinase Genes with Down in Fatal; (HL) inhibitor 2A (melanoma, prognostic Up in Cured p16, inhibits CDK4) value Survival NM_005215 DCC deleted in colorectal Genes with Down in Fatal; (HL) carcinoma prognostic Up in Cured value Survival NM_004119 FLT3 fms-related tyrosine Genes with Down in Fatal; (HL) kinase 3 prognostic Up in Cured value HL vs. NM_002086 GRB2 growth factor receptor- Differentially Up only in HL ALCL bound protein 2 regulated between ALCL and HL HL vs. NM_176783 PSME1 proteasome (prosome, Differentially Up only in ALCL macropain) activator regulated ALCL subunit 1 (PA28 between aHCPha) ALCL and HL HL vs. NM_002961 S100A4 S100 calcium binding Differentially Up only in HL ALCL protein A4 (calcium regulated protein, calvasculin, between metastasin, murine ALCL and HL placental homolog) HL NM_000698 ALOX5 arachidonate 5- Genes unique Down in HL Signature lipoxygenase to Reed/Sternberg cells HL NM_001715 BLK B lymphoid tyrosine Genes unique Down in HL Signature kinase to Reed/Sternberg cells HL NM_002987 CCL17 chemokine (C-C motif) Genes unique Up in HL Signature ligand 17 to Reed/Sternberg cells HL NM_001783 CD79A CD79A antigen Genes unique Down in HL Signature (immunoglobulin- to associated aHCPha) Reed/Sternberg cells HL NM_000626 CD79B CD79B antigen Genes unique Down in HL Signature (immunoglobulin- to associated beta) Reed/Sternberg cells HL NM_182908 DHRS2 dehydrogenase/reductase Genes unique Up in HL Signature (SDR family) member 2 to Reed/Sternberg cells HL NM_004434 EML1 echinoderm microtubule Genes unique Up in HL Signature associated protein like 1 to Reed/Sternberg cells HL NM_006495 EVI2B ecotropic viral Genes unique Down in HL Signature integration site 2B to Reed/Sternberg cells HL NM_013451 FER1L3 fer-1-like 3, myoferlin Genes unique Up in HL Signature (C. elegans) to Reed/Sternberg cells HL NM_002048 GAS1 growth arrest-specific 1 Genes unique Up in HL Signature to Reed/Sternberg cells HL BM722299 H2AFB H2A histone family, Genes unique Up in HL Signature member B to Reed/Sternberg cells HL NM_002167 ID3 inhibitor of DNA Genes unique Down in HL Signature binding 3, dominant to negative helix-loop-helix Reed/Sternberg protein cells HL BC011857 IGHM Immunoglobulin heavy Genes unique Down in HL Signature constant mu to Reed/Sternberg cells HL NM_005933 MLL myeloid/lymphoid or Genes unique Down in HL Signature mixed-lineage leukemia to (trithorax homolog, Reed/Sternberg Drosophila) cells HL NM_152866 MS4A1 membrane-spanning 4- Genes unique Down in HL Signature domains, subfamily A, to member 1 Reed/Sternberg cells HL AB033114 MTSG1 mitochondrial tumor Genes unique Up in HL Signature suppressor gene 1 to Reed/Sternberg cells HL NM_004289 NFE2L3 nuclear factor (erythroid- Genes unique Up in HL Signature derived 2)-like 3 to Reed/Sternberg cells HL NM_020992 PDLIM1 PDZ and LIM domain 1 Genes unique Down in HL Signature (elfin) to Reed/Sternberg cells HL NM_002661 PLCG2 phospholipase C, gamma Genes unique Down in HL Signature 2 (phosphatidylinositol- to specific) Reed/Sternberg cells HL NM_006115 PRAME preferentially expressed Genes unique Up in HL Signature antigen in melanoma to Reed/Sternberg cells HL NM_002838 PTPRC protein tyrosine Genes unique Down in HL Signature phosphatase, receptor to type, C Reed/Sternberg cells HL NM_015055 SWAP70 SWAP-70 protein Genes unique Down in HL Signature to Reed/Sternberg cells HL NM_004665 VNN2 vanin 2 Genes unique Down in HL Signature to Reed/Sternberg cells Signature; NM_003254 TIMP1 tissue inhibitor of Genes unique Disagreement: Up HL vs. metalloproteinase 1 to in HL; Up ALCL; (erythroid potentiating Reed/Sternberg only in ALCL; Survival activity, collagenase cells; Up in Fatal; inhibitor) Differentially Down in Cured regulated between ALCL and HL; Genes with prognostic value Survival NM_024408 NOTCH2 Notch homolog 2 Genes with Down in Fatal; (HL) (Drosophila) prognostic Up in Cured value Survival NM_000314 PTEN phosphatase and tensin Genes with Down in Fatal; (HL) homolog (mutated in prognostic Up in Cured multiple advanced value cancers 1) Survival NM_003005 SEHCP selectin P (granule Genes with Up in Fatal; (HL) membrane protein prognostic Down in Cured 140 kDa, antigen CD62) value Survival NM_003810 TNFSF10 tumor necrosis factor Genes with Down in Fatal; (HL) (ligand) superfamily, prognostic Up in Cured member 10 value HL vs. NM_005178 BCL3 B-cell CLL/lymphoma 3 Diagnostic Up only in ALCL Marker ALCL HL vs. NM_000485 APRT adenine Differentially Up in Both HL ALCL phosphoribosyltransferase regulated and ALCL between ALCL and HL HL vs. NM_001728 BSG basigin (OK blood Differentially Up only in ALCL group) regulated ALCL between ALCL and HL HL vs. NM_006763 BTG2 BTG family, member 2 Differentially Up in Both HL ALCL regulated and ALCL between ALCL and HL HL vs. NM_001743 CALM2 calmodulin 2 Differentially Up in Both HL ALCL (phosphorylase kinase, regulated and ALCL delta) between ALCL and HL HL vs. NM_033306 CASP4 caspase 4, apoptosis- Differentially Up only in ALCL related cysteine protease regulated ALCL between ALCL and HL HL vs. NM_005340 HINT1 histidine triad nucleotide Differentially Up only in ALCL binding protein 1 regulated ALCL between ALCL and HL HL vs. NM_002228 JUN v-jun sarcoma virus 17 Differentially Up only in HL ALCL oncogene homolog regulated (avian) between ALCL and HL HL vs. NM_006191 PA2G4 proliferation-associated Differentially Up in Both HL ALCL 2G4, 38 kDa regulated and ALCL between ALCL and HL HL vs. NM_030666 SERPINB1 serine (or cysteine) Differentially Up in Both HL ALCL proteinase inhibitor, regulated and ALCL clade B (ovalbumin), between member 1 ALCL and HL HL vs. NM_003955 SOCS3 suppressor of cytokine Differentially Up only in ALCL signaling 3 regulated ALCL between ALCL and HL HL vs. NM_003254 TIMP1 tissue inhibitor of Genes unique Disagreement: Up ALCL metalloproteinase 1 to in HL; Up (erythroid potentiating Reed/Sternberg only in ALCL; activity, collagenase cells; Up in Fatal; inhibitor) Differentially Down in Cured regulated between ALCL and HL; Genes with prognostic value

TABLE 9 An HCP set specific for MCL, according to one embodiment of the invention Feature Accession Symbol Name Notes Level MCL vs. NM_001675 ATF4 activating transcription High in Up in MCL- MCL-BV factor 4 (tax-responsive Aggressive BV vs. MCL enhancer element B67) Blast Variant MCL vs. NM_001826 CKS1B CDC28 protein kinase High in Up in MCL- MCL-BV regulatory subunit 1B Aggressive BV vs. MCL Blast Variant; RT-Confirmed MCL vs. NM_001831 CLU clusterin (complement RT-Confirmed Up in MCL- MCL-BV lysis inhibitor, SP- BV vs. MCL 40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) MCL vs. NM_001344 DAD1 defender against cell RT-Confirmed Up in MCL- MCL-BV death 1 BV vs. MCL MCL vs. NM_005243 EWSR1 Ewing sarcoma RT-Confirmed Up in MCL- MCL-BV breakpoint region 1 BV vs. MCL MCL vs. NM_006769 LMO4 LIM domain only 4 High in Up in MCL- MCL-BV Aggressive BV vs. MCL Blast Variant; RT-Confirmed MCL vs. NM_005582 LY64 lymphocyte antigen 64 High in Up in MCL- MCL-BV homolog, Aggressive BV vs. MCL radioprotective 105 kDa Blast Variant; (mouse) RT-Confirmed MCL vs. NM_004689 MTA1 metastasis associated 1 RT-Confirmed Up in MCL- MCL-BV BV vs. MCL MCL vs. NM_002466 MYBL2 v-myb myeloblastosis RT-Confirmed Up in MCL- MCL-BV viral oncogene BV vs. MCL homolog (avian)-like 2 MCL vs. NM_002648 PIM1 pim-1 oncogene High in Up in MCL- MCL-BV Aggressive BV vs. MCL Blast Variant; RT-Confirmed MCL vs. NM_003403 YY1 YY1 transcription High in Up in MCL- MCL-BV factor Aggressive BV vs. MCL Blast Variant; RT-Confirmed MCL NM_053056 CCND1 cyclin D1 (PRAD1: RT-PCR Up in MCL; Signature parathyroid Comparison of Down in adenomatosis 1) CLL and MCL DLBCL; Up in MCL; up in MCL MCL NM_000633 BCL2 B-cell CLL/lymphoma 2 Gene High in MCL Signature Expression and DLBCL Analysis in cell lines; MCL cell lines; Down in RT-PCR MCL & Comparison of MZL, Up in CLL, MCL & CLL MZL MCL NM_002162 ICAM3 intercellular adhesion Strong Down in Signature molecule 3 Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs Survival; NM_002592 PCNA proliferating cell Proliferation High in Short MCL vs. nuclear antigen Signature Survival; Up MCL-BV in MCL-BV vs. MCL MCL NM_000698 ALOX5 arachidonate 5- up in MCL lipoxygenase (5.8) MCL vs. NM_005104 BRD2 bromodomain High in Up in MCL- MCL-BV containing 2 Aggressive BV vs. MCL Blast Variant MCL vs. NM_001728 BSG basigin (OK blood High in Up in MCL- MCL-BV group) Aggressive BV vs. MCL Blast Variant MCL vs. NM_001469 G22P1 thyroid autoantigen High in Up in MCL- MCL-BV 70 kDa (Ku antigen) Aggressive BV vs. MCL Blast Variant MCL vs. NM_031844 HNRPU heterogeneous nuclear High in Up in MCL- MCL-BV ribonucleoprotein U Aggressive BV vs. MCL (scaffold attachment Blast Variant factor A) MCL vs. NM_002460 IRF4 interferon regulatory High in Up in MCL- MCL-BV factor 4 Aggressive BV vs. MCL Blast Variant MCL vs. NM_006152 LRMP lymphoid-restricted High in Up in MCL- MCL-BV membrane protein Aggressive BV vs. MCL Blast Variant MCL vs. NM_006819 STIP1 stress-induced- High in Up in MCL- MCL-BV phosphoprotein 1 Aggressive BV vs. MCL (Hsp70/Hsp90- Blast Variant organizing protein) MCL NM_001092 ABR active BCR-related Signature genes Down in Signature gene common to both DLBCL; Up Shipp and in MCL Alizadeh; Strong Classifier Separating MCLs and DLBCLs MCL NM_156039 CSF3R colony stimulating Strong Down in Signature factor 3 receptor Classifier DLBCL; Up (granulocyte) Separating in MCL MCLs and DLBCLs MCL NM_004941 DHX8 DEAH (Asp-Glu-Ala- Strong Down in Signature His) box polypeptide 8 Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs MCL BC025340 MGC39372 hypothetical protein up in MCL MGC39372 (8.4); down in FL vs MCL (−13.6); up in MCL vs SLL (6.3) MCL NM_004513 IL16 interleukin 16 up in FL vs (lymphocyte MCL (4.9); chemoattractant factor) down in MCL vs SLL (−7.8) MCL vs NM_002466 MYBL2 v-myb myeloblastosis up in MCL vs CLL/SLL viral oncogene SLL (5.1) homolog (avian)-like 2 Signature; NM_000075 CDK4 cyclin-dependent RT-PCR Up in MCL; MCL vs. kinase 4 Comparison of Up in MCL- MCL-BV CLL and MCL; BV vs. MCL RT confirmed CLL/SLL AB018263 KIAA0720 putative NFkB Up in MCL vs MCL activating protein vs SLL (4.3) FL; MCL NM_000424 KRT5 keratin 5 down in FL (−5.3); (epidermolysis bullosa down in simplex, Dowling- MCL (−4) Meara/Kobner/Weber- Cockayne types) FL vs AB037771 USP53 ubiquitin specific up in FL vs MCL protease 53 MCL (4.2) MCL vs NM_032873 KIAA1959 nm23-phosphorylated down in CLL/SLL unknown substrate MCL vs SLL (−5.3) FL vs NM_000418 IL4R interleukin 4 receptor up in FL vs MCL MCL (5.4) MCL vs NM_000418 IL4R interleukin 4 receptor down in CLL/SLL MCL vs SLL (−7.1) MCL vs NM_023037 13CDNA73 hypothetical protein MCL vs SLL CLL/SLL CG003 (−7.6) MCL AF509494 KIAA1407 KIAA1407 protein up in MCL (10) FL vs NM_001781 CD69 CD69 antigen (p60, down in FL MCL early T-cell activation vs MCL (−4.1) antigen) MCL vs NM_030926 ITM2C integral membrane up in MCL vs SLL protein 2C SLL MCL AF331856 DNMT3A DNA (cytosine-5-)- down in FL methyltransferase 3 vs MCL (−8); aHCPha up in MCL vs SLL (5.2) FL vs NM_000405 GM2A GM2 ganglioside down in FL MCL activator vs MCL (−4.4) CLL/SLL NM_000483 APOC2 apolipoprotein C-II up in MCL vs vs MCL SLL (5.6) FL vs NM_002228 JUN v-jun sarcoma virus 17 down in FL MCL oncogene homolog vs MCL (−4.6) (avian) FL vs NM_006889 CD86 CD86 antigen (CD28 up in FL vs MCL antigen ligand 2, B7-2 MCL (7.9) antigen) CLL/SLL NM_003480 MFAP5 microfibrillar up in MCL vs vs MCL associated protein 5 CLL/SLL (4.2) MCL NM_181430 ILF1 interleukin enhancer Strong Down in Signature binding factor 1 Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs MCL NM_003222 TFAP2C transcription factor AP- down in 2 gamma (activating MCL (−8.2) enhancer binding protein 2 gamma) FL vs NM_006164 NFE2L2 nuclear factor up in FL vs MCL (erythroid-derived 2)- MCL (4.1) like 2 MCL NM_004235 KLF4 Kruppel-like factor 4 up in MCL (gut) (5) MCL vs NM_003651 CSDA cold shock domain down in CLL/SLL protein A MCL vs SLL (−4.4) MCL NM_001888 CRYM crystallin, mu up in MCL (8.5); down in FL vs MCL (−7.3); up in MCL vs SLL (9.3) MCL NM_001675 ATF4 activating transcription up in MCL factor 4 (tax-responsive (4.3) enhancer element B67) MCL NM_003804 RIPK1 receptor (TNFRSF)- down in interacting serine- MCL (−4.2) threonine kinase 1 MCL NM_004924 ACTN4 actinin, aHCPha 4 up in MCL (4.5) FL vs NM_018842 LOC55971 insulin receptor down in FL MCL tyrosine kinase vs MCL (−8.4) substrate MCL NM_002483 CEACAM6 carcinoembryonic down in antigen-related cell MCL (−4.4); adhesion molecule 6 up in FL vs (non-specific cross MCL (4.7) reacting antigen) FL vs NM_001640 APEH N-acylaminoacyl- down in MCL peptide hydrolase MCL (−6.5); up in FL vs MCL (6) FL vs NM_006475 POSTN periostin, osteoblast Up in FL vs MCL specific factor MCL (4) MCL NM_000700 ANXA1 annexin A1 down in MCL (−4.1) FL vs NM_021813 BACH2 BTB and CNC up in FL vs MCL homology 1, basic MCL (5.5) leucine zipper transcription factor 2 DLBCL NM_053056 CCND1 cyclin D1 (PRAD1: Strong Down in vs. MCL parathyroid Classifier DLBCL; Up adenomatosis 1) Separating in MCL MCLs and DLBCLs CLL vs. NM_002467 MYC v-myc RT-PCR High in CLL MCL myelocytomatosis viral analysis shows oncogene homolog up regulation in (avian) CLL CLL/SLL NM_002933 RNASE1 ribonuclease, RNase A down in vs MCL family, 1 (pancreatic) MCL vs SLL (−5.4) MCL NM_022829 SLC13A3 solute carrier family 13 up in MCL (sodium-dependent (4.9) dicarboxylate transporter), member 3 MCL NM_003339 UBE2D2 ubiquitin-conjugating up in MCL enzyme E2D 2 (4.4) (UBC4/5 homolog, yeast) ABC VS NM_001092 ABR active BCR-related Signature genes Uncertain in GC gene common to both Common DLBCL; Shipp and Genes; Down DLBCL Alizadeh; in DLBCL; vs. MCL Strong Up in MCL Classifier Separating MCLs and DLBCLs DBFCL NM_002162 ICAM3 intercellular adhesion Expression in Down in Vs. FL; molecule 3 FL to DLBCL Transformed DLBCL transformation; DLBCL; vs. MCL Strong Down in Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs FL vs NM_024728 C7orf10 chromosome 7 open up in FL vs MCL reading frame 10 MCL (4.5) MCL NM_025263 PRR3 proline rich 3 up in MCL (4.3) DLBCL NM_019841 TRPV5 transient receptor Strong Down in vs. MCL; potential cation Classifier DLBCL; Up CD5+/− channel, subfamily V, Separating in MCL; DLBCL member 5 MCLs and Down in DLBCLs and CD5+; Up in CD5+ from CD5− CD5− DLBCLs MCL NM_024713 FLJ22557 hypothetical protein up in MCL FLJ22557 (15.7) MCL AK092000 SLC3A1 solute carrier family 3 up in MCL (cystine, dibasic and (4.3) neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 MCL NM_022436 ABCG5 ATP-binding cassette, down in sub-family G MCL (−4.1) (WHITE), member 5 (sterolin 1) MCL NM_004475 FLOT2 flotilline 2 Strong Down in Signature Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs DLBCL NM_134269 SMTN smoothelin Strong Down in vs. MCL Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs CLL vs. NM_000075 CDK4 cyclin-dependent MCL, CLL High in CLL MCL kinase 4 Signature&CLL Vs. MCL Distinguisher DLBCL NM_004941 DHX8 DEAH (Asp-Glu-Ala- Strong Down in vs. MCL His) box polypeptide 8 Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs DLBCL NM_004475 FLOT2 flotillin 2 Strong Down in vs. MCL Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs DLBCL NM_181430 ILF1 interleukin enhancer Strong Down in vs. MCL binding factor 1 Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs DLBCL NM_156039 CSF3R colony stimulating Strong Down in vs. MCL factor 3 receptor Classifier DLBCL; Up (granulocyte) Separating in MCL MCLs and DLBCLs DLBCL NM_000277 PAH phenylalanine Strong Down in vs. MCL hydroxylase Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs MCL BC022095 C6orf110 chromosome 6 open up in MCL reading frame 110 (4.8) MCL NM_031305 ARHGAP24 Rho GTPase activating up in MCL protein 24 (5.6) MCL AB029034 PHF8 PHD finger protein 8 down in MCL (−5.8) MCL NM_198243 ASB7 ankyrin repeat and down in SOCS box-containing 7 MCL (−6) MCL NM_016570 PTX1 PTX1 protein up in FL vs MCL (5.8); down in MCL vs SLL (−8.8) MCL BC001077 LOC87769 hypothetical protein down in BC004360 MCL (−4.9) MCL NM_138379 LOC91937 hypothetical protein down in BC008988 MCL (−4.1); down in MCL vs SLL (−4.3) FL vs NM_015670 SENP3 SUMO1/sentrin/SMT3 up in FL vs MCL specific protease 3 MCL MCL BX647445 GTF2H2 general transcription up in MCL factor IIH, polypeptide (5.9) 2, 44 kDa MCL NM_030956 TLR10 toll-like receptor 10 Molecular Up in MCL Signature Diagnosis vs. CLL/DLBCL MCL NM_000277 PAH phenylalanine Strong Down in Signature hydroxylase Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs MCL NM_134269 SMTN smoothelin Strong Down in Signature Classifier DLBCL; Up Separating in MCL MCLs and DLBCLs MCL NM_019841 TRPV5 transient receptor Strong Down in Signature potential cation Classifier DLBCL; Up channel, subfamily V, Separating in MCL; member 5 MCLs and Down in DLBCLs and CD5+; Up in CD5+ from CD5− CD5− DLBCLs MCL NM_001760 CCND3 cyclin D3 RT-PCR Up in MCL Signature Comparison of vs. CLL CLL and MCL MCL NM_004064 CDKN1B cyclin-dependent RT-PCR Down in Signature kinase inhibitor 1B Comparison of MCL vs. (p27, Kip1) CLL and MCL CLL MCL NM_005225 E2F1 E2F transcription RT-PCR Up in MCL Signature factor 1 Comparison of vs. CLL CLL and MCL MCL NM_003810 TNFSF10 tumor necrosis factor RT-PCR Up in MCL Signature (ligand) superfamily, Comparison of vs. CLL member 10 CLL and MCL MCL NM_013995 LAMP2 lysosomal-associated Gene High in MCL Signature membrane protein 2 Expression and DLBCL Analysis in cell lines MCL cell lines MCL NM_000698 ALOX5 arachidonate 5- Molecular Up in MCL Signature lipoxygenase Diagnosis vs. CLL/DLBCL MCL NM_017935 BANK1 B-cell scaffold protein Molecular Up in MCL Signature with ankyrin repeats 1 Diagnosis vs. CLL/DLBCL MCL NM_004126 GNG11 guanine nucleotide Molecular Up in MCL Signature binding protein (G Diagnosis vs. protein), gamma 11 CLL/DLBCL MCL NM_000598 IGFBP3 insulin-like growth Molecular Up in MCL Signature factor binding protein 3 Diagnosis vs. CLL/DLBCL MCL NM_007360 KLRK1 killer cell lectin-like Molecular Up in MCL Signature receptor subfamily K, Diagnosis vs. member 1 CLL/DLBCL CLL vs. NM_004454 ETV5 ets variant gene 5 (ets- RT-PCR High in CLL MCL related molecule) analysis shows up regulation in CLL MCL NM_001647 APOD apolipoprotein D up in MCL (5.5); down in FL vs MCL (−8.3) MCL NM_015436 RCHY1 ring finger and CHY up in MCL zinc finger domain (4.3) containing 1 CLL vs. NM_001760 CCND3 cyclin D3 CLL Vs. MCL High in CLL MCL Distinguisher MCL NM_017784 OSBPL10 oxysterol binding up in MCL protein-like 10 (4.7) CLL/SLL NM_020944 GBA2 glucosidase, beta (bile down in vs MCL acid) 2 MCL vs SLL (−5.1) CLL vs. NM_053056 CCND1 cyclin D1 MCL, CLL High in CLL MCL (BCL1/PRAD1: Signature&CLL parathyroid Vs. MCL adenomatosis 1) Distinguisher MCL NM_004225 MFHAS1 malignant fibrous Molecular Up in MCL Signature histiocytoma amplified Diagnosis vs. sequence 1 CLL/DLBCL MCL NM_014257 CD209L CD209 antigen-like down in MCL (−5.1); down in MCL vs SLL (−4.8) MCL NM_152866 MS4A1 membrane-spanning 4- Molecular Up in MCL Signature domains, subfamily A, Diagnosis vs. member 1 CLL/DLBCL MCL NM_004827 ABCG2 ATP-binding cassette, down in sub-family G MCL (−4.6) (WHITE), member 2 Survival NM_006325 RAN RAN, member RAS Proliferation High in Short (MCL) oncogene family Signature Survival Survival NM_002129 HMGB2 high-mobility group Proliferation High in Short (MCL) box 2 Signature Survival MCL NM_003254 TIMP1 tissue inhibitor of RT-PCR Up in MCL, Signature metalloproteinase 1 Comparison of Down in (erythroid potentiating CLL, MCL & MZL and activity, collagenase MZL CLL inhibitor) MCL NM_024408 NOTCH2 Notch homolog 2 RT-PCR Down in Signature (Drosophila) Comparison of MCL & CLL, CLL, MCL & Up in MZL MZL CLL vs. NM_004064 CDKN1B cyclin-dependent MCL, CLL High in CLL MCL kinase inhibitor 1B Signature&CLL (p27, Kip1) Vs. MCL Distinguisher CLL/SLL NM_001830 CLCN4 chloride channel 4 down in vs MCL MCL vs SLL (−4.9)

TABLE 10 An HCP set specific for DLBCL, according to one embodiment of the invention DLBCL Signature Accession Symbol NM_000785.2 CYP27B1 NM_005652.2 TERF2 NM_006317.3 BASP1 NM_057735.1 CCNE2 NM_145804.1 ABTB2 NM_182776.1 MCM7 NM_001067.2 TOP2A NM_002426.1 MMP12 NM_000075.2 CDK4 NM_000877.2 IL1R1 NM_002661.1 PLCG2 NM_005658.2 TRAF1 NM_001951.2 E2F5 NM_002358.2 MAD2L1 NM_021950.2 MS4A1 NM_000269.2 NME1 NM_001826.1 CKS1B NM_175870.3 LOC90925 NM_182746.1 MCM4 NM_004460.2 FAP NM_006892.3 DNMT3B NM_012203.1 GRHPR AI809213.1 RGS13 NM_001197.3 BIK NM_001618.2 PARP1 NM_001771.1 CD22 NM_002692.2 POLE2 NM_031942.3 CDCA7 NM_015641.2 TES NM_014456.3 PDCD4 NM_181443.1 BTBD3 H57732.1 TGFBR2 NM_004445.1 EPHB6 NM_003243.1 TGFBR3 NM_004951.2 EBI2 NM_005935.1 MLLT2 NM_000633.1 BCL2 NM_000927.3 ABCB1 NM_002350.1 LYN NM_001558.2 IL10RA NM_005213.2 CSTA NM_005127.2 CLECSF2 W56129.1 SFRS9 NM_004358.3 CDC25B NM_004126.2 GNG11 BX504817.1 SFRS7 AI597616.1 MRPL33 NM_006257.2 PRKCQ NM_000873.2 ICAM2 NM_002943.2 RORA NM_001230.3 CASP10

TABLE 11 An HCP set specific for FL, according to one embodiment of the invention FL Signature Accession Symbol NM_004619.2 TRAF5 NM_015187.1 KIAA0746 NM_006317.3 BASP1 NM_152785.2 GCET2 NM_006558.1 KHDRBS3 NM_017784.3 OSBPL10 NM_145804.1 ABTB2 NM_006475.1 POSTN NM_002002.3 FCER2 NM_000877.2 IL1R1 NM_001770.3 CD19 NM_004356.2 CD81 NM_005658.2 TRAF1 NM_006986.2 MAGED1 NM_001951.2 E2F5 NM_021950.2 MS4A1 NM_175870.3 LOC90925 NM_182746.1 MCM4 NM_002646.2 PIK3C2B NM_144646.2 IGJ NM_001242.3 TNFRSF7 H53164.1 IRF8 NM_001877.2 CR2 NM_005292.2 GPR18 NM_005214.2 CTLA4 AI809213.1 RGS13 AI634809.1 ARID5B NM_013230.1 CD24 NM_000237.1 LPL NM_138379.1 TIMD4 NM_001197.3 BIK NM_001831.2 CLU NM_002101.3 GYPC NM_001618.2 PARP1 NM_001771.1 CD22 NM_016336.2 UBE2J1 NM_030764.2 SPAP1 NM_031942.3 CDCA7 NM_006274.2 CCL19 NM_016187.1 BIN2 NM_000271.1 NPC1 NM_138340.3 ABHD3 NM_003332.2 TYROBP NM_006254.3 PRKCD NM_003243.1 TGFBR3 NM_002350.1 LYN NM_000917.1 P4HA1 NM_005077.3 TLE1 NM_004184.3 WARS NM_005601.3 NKG7 NM_032991.1 CASP3 NM_003810.2 TNFSF10 NM_001425.1 EMP3 NM_000397.2 CYBB NM_002155.3 HSPA6 NM_005610.1 RBBP4 NM_005638.3 SYBL1 NM_001110.1 ADAM10 NM_001350.2 DAXX NM_000295.3 SERPINA1 BX504817.1 SFRS7 AI597616.1 MRPL33 NM_000585.2 IL15 NM_002305.2 LGALS1 NM_007311.2 BZRP NM_006332.3 IFI30 NM_007360.1 KLRK1 NM_024708.2 ASB7 NM_033208.2 TIGD7 NM_000189.4 HK2

TABLE 12 An HCP set specific for HL, according to one embodiment of the invention HL Signature Accession Symbol NM_006274.2 CCL19 NM_000785.2 CYP27B1 NM_014762.1 DHCR24 NM_005606.3 LGMN NM_003226.2 TFF3 NM_002426.1 MMP12 NM_000877.2 IL1R1 NM_004356.2 CD81 NM_000483.3 APOC2 NM_005658.2 TRAF1 NM_003037.1 SLAMF1 NM_006115.3 PRAME NM_000853.1 GSTT1 NM_002646.2 PIK3C2B NM_016081.2 KIAA0992 NM_005214.2 CTLA4 AK022231.1 STAT1 NM_173624.1 FLJ40504 NM_001353.4 AKR1C1 NM_020529.1 NFKBIA NM_014338.3 PISD NM_003243.1 TGFBR3 NM_004951.2 EBI2 NM_002350.1 LYN NM_079421.2 CDKN2D U90916.1 SORL1 NM_005213.2 CSTA NM_002155.3 HSPA6 NM_004126.2 GNG11 NM_023037.1 13CDNA73 AI597616.1 MRPL33 NM_007360.1 KLRK1 AW291384.1 STS-1

TABLE 13 An HCP set specific for MCL, according to one embodiment of the invention MCL Signature Accession Symbol NM_004851.1 NAPSA NM_004619.2 TRAF5 NM_015187.1 KIAA0746 NM_002250.2 KCNN4 NM_012452.2 TNFRSF13B NM_006317.3 BASP1 NM_017530.1 LOC55565 NM_017784.3 OSBPL10 R99527.1 MGC39372 NM_182776.1 MCM7 NM_003177.3 SYK L29376.1 3.8-1 NM_001770.3 CD19 NM_002661.1 PLCG2 NM_201593.1 CACNB2 NM_001951.2 E2F5 NM_006162.3 NFATC1 NM_020992.2 PDLIM1 NM_002120.2 HLA-DOB NM_021950.2 MS4A1 NM_003362.2 UNG NM_175870.3 LOC90925 NM_000405.3 GM2A NM_002095.3 GTF2E2 NM_002646.2 PIK3C2B NM_001242.3 TNFRSF7 NM_014686.2 KIAA0355 AA594161.1 MYH11 NM_033274.1 ADAM19 NM_000626.1 CD79B NM_022552.3 DNMT3A NM_001877.2 CR2 U37028.1 ITGAD NM_014246.1 CELSR1 AA766908.1 MME BQ632574.1 RASA1 NM_013230.1 CD24 NM_003451.1 ZNF177 NM_000237.1 LPL NM_001618.2 PARP1 NM_001771.1 CD22 NM_004556.1 NFKBIE NM_030764.2 SPAP1 NM_031305.1 ARHGAP24 NM_017935.2 BANK1 NM_025113.1 C13orf18 AK055652.1 C3orf6 BG993697.1 SMYD3 NM_016187.1 BIN2 NM_138340.3 ABHD3 NM_003332.2 TYROBP NM_014338.3 PISD NM_012448.3 STAT5B NM_198833.1 SERPINB8 NM_001760.2 CCND3 NM_004184.3 WARS NM_005601.3 NKG7 NM_006889.2 CD86 NM_003037.1 SLAMF1 NM_003810.2 TNFSF10 U90916.1 SORL1 NM_005213.2 CSTA NM_002051.2 GATA3 NM_000043.3 FAS NM_005013.1 NUCB2 NM_001779.1 CD58 NM_030666.2 SERPINB1 NM_006620.2 HBS1L NM_001621.2 AHR NM_004635.3 MAPKAPK3 NM_023037.1 13CDNA73 NM_000295.3 SERPINA1 AI597616.1 MRPL33 NM_002966.1 S100A10 NM_000576.2 IL1B NM_006498.1 LGALS2 NM_006257.2 PRKCQ NM_003656.3 CAMK1 NM_004529.1 MLLT3 NM_006332.3 IFI30

TABLE 14 An HCP set specific for MZL, according to one embodiment of the invention MZL Signature Accession Symbol NM_004619.2 TRAF5 NM_006274.2 CCL19 NM_003959.1 HIP1R NM_014257.3 CD209L NM_015187.1 KIAA0746 NM_001894.4 CSNK1E NM_002250.2 KCNN4 NM_012452.2 TNFRSF13B NM_006317.3 BASP1 NM_006558.1 KHDRBS3 NM_017530.1 LOC55565 NM_017784.3 OSBPL10 NM_145804.1 ABTB2 NM_014762.1 DHCR24 NM_182776.1 MCM7 NM_004445.1 EPHB6 NM_001888.1 CRYM NM_003226.2 TFF3 NM_003177.3 SYK NM_001853.2 COL9A3 NM_000075.2 CDK4 NM_002002.3 FCER2 NM_001770.3 CD19 NM_000483.3 APOC2 NM_000109.2 DMD NM_006986.2 MAGED1 NM_003088.2 FSCN1 NM_001951.2 E2F5 NM_006841.3 SLC38A3 NM_006761.3 YWHAE NM_004073.2 PLK3 NM_006162.3 NFATC1 NM_002120.2 HLA-DOB NM_002738.5 PRKCB1 NM_021950.2 MS4A1 NM_000269.2 NME1 NM_175870.3 LOC90925 NM_000405.3 GM2A NM_002217.1 ITIH3 NM_000853.1 GSTT1 NM_021966.1 TCL1A NM_002646.2 PIK3C2B NM_144646.2 IGJ NM_001242.3 TNFRSF7 NM_030775.2 WNT5B NM_000626.1 CD79B NM_001877.2 CR2 NM_004422.2 DVL2 U37028.1 ITGAD NM_006892.3 DNMT3B AI809213.1 RGS13 AI634809.1 ARID5B AA766908.1 MME BQ632574.1 RASA1 NM_173624.1 FLJ40504 NM_013230.1 CD24 NM_001647.1 APOD AK022293.1 CTSD NM_080881.1 DBN1 NM_001782.1 CD72 NM_000237.1 LPL NM_004844.1 SH3BP5 NM_001197.3 BIK NM_006763.2 BTG2 NM_001353.4 AKR1C1 NM_000424.2 KRT5 NM_001771.1 CD22 NM_002832.2 PTPN7 NM_002891.3 RASGRF1 AW271958.1 TYMS NM_025216.2 WNT10A NM_030764.2 SPAP1 NM_031942.3 CDCA7 X58529.1 IGHM NM_001852.3 COL9A2 NM_018842.3 BAIAP2L1 NM_025113.1 C13orf18 NM_002122.2 HLA-DQA1 AK055652.1 C3orf6 NM_000271.1 NPC1 NM_138340.3 ABHD3 NM_003332.2 TYROBP NM_020199.1 C5orf15 NM_004117.2 FKBP5 NM_004289.5 NFE2L3 NM_177968.1 PPM1B NM_015641.2 TES NM_080593.1 HIST1H2BK NM_015866.2 PRDM2 T66903.1 LOC54103 NM_001154.2 ANXA5 NM_002467.2 MYC NM_005935.1 MLLT2 NM_001762.2 CCT6A NM_000313.1 PROS1 NM_000927.3 ABCB1 NM_002350.1 LYN NM_005271.1 GLUD1 NM_000917.1 P4HA1 NM_000655.2 SELL NM_000788.1 DCK NM_000038.2 APC M80899.1 MGC5395 NM_172373.2 ELF1 NM_001760.2 CCND3 NM_001663.2 ARF6 NM_004184.3 WARS NM_005461.3 MAFB NM_005601.3 NKG7 NM_006889.2 CD86 NM_003875.1 GMPS NM_032991.1 CASP3 NM_003810.2 TNFSF10 NM_004354.1 CCNG2 NM_003915.2 RBM12 U90916.1 SORL1 NM_000397.2 CYBB NM_005348.2 HSPCA NM_002526.1 NT5E NM_001068.2 TOP2B NM_005610.1 RBBP4 NM_005013.1 NUCB2 NM_005638.3 SYBL1 NM_005127.2 CLECSF2 NM_002838.2 PTPRC NM_006006.3 ZBTB16 NM_006218.1 PIK3CA NM_002306.1 LGALS3 NM_139276.2 STAT3 NM_000627.2 LTBP1 NM_030666.2 SERPINB1 NM_002967.2 SAFB NM_003217.1 TEGT NM_018442.1 IQWD1 NM_004125.2 GNG10 NM_181838.1 UBE2D2 W56129.1 SFRS9 NM_002211.2 ITGB1 NM_004126.2 GNG11 NM_000584.2 IL8 NM_006195.2 PBX3 NM_023037.1 13CDNA73 NM_000295.3 SERPINA1 NM_004049.2 BCL2A1 NM_002966.1 S100A10 NM_000585.2 IL15 NM_003656.3 CAMK1 NM_000579.1 CCR5 NM_001967.2 EIF4A2 NM_002752.3 MAPK9 NM_002892.2 ARID4A NM_002943.2 RORA NM_006164.2 NFE2L2 NM_006644.2 HSPH1 NM_007360.1 KLRK1 NM_016628.2 WAC NM_021822.1 APOBEC3G NM_024708.2 ASB7 NM_000713.1 BLVRB

TABLE 15 An HCP set specific for SLL, according to one embodiment of the invention SLL Signature Accession Symbol NM_004619.2 TRAF5 NM_006274.2 CCL19 NM_014257.3 CD209L NM_015187.1 KIAA0746 NM_001894.4 CSNK1E NM_002250.2 KCNN4 NM_017530.1 LOC55565 NM_017784.3 OSBPL10 NM_006734.2 HIVEP2 NM_003226.2 TFF3 NM_003177.3 SYK L29376.1 3.8-1 NM_001853.2 COL9A3 NM_000075.2 CDK4 NM_002002.3 FCER2 NM_001770.3 CD19 NM_000109.2 DMD NM_201593.1 CACNB2 NM_001951.2 E2F5 NM_006841.3 SLC38A3 NM_004073.2 PLK3 NM_006162.3 NFATC1 NM_002120.2 HLA-DOB NM_002738.5 PRKCB1 NM_021950.2 MS4A1 NM_003362.2 UNG NM_000269.2 NME1 NM_021966.1 TCL1A NM_001242.3 TNFRSF7 H53164.1 IRF8 AA594161.1 MYH11 NM_000626.1 CD79B NM_001877.2 CR2 NM_006892.3 DNMT3B AI634809.1 ARID5B BQ632574.1 RASA1 AI672553.1 AKAP12 NM_002567.2 PBP NM_173624.1 FLJ40504 NM_013230.1 CD24 NM_003451.1 ZNF177 AK022293.1 CTSD NM_005449.3 TOSO NM_001782.1 CD72 NM_000237.1 LPL NM_004844.1 SH3BP5 NM_001197.3 BIK NM_001353.4 AKR1C1 NM_001552.1 IGFBP4 NM_001771.1 CD22 NM_002692.2 POLE2 NM_002832.2 PTPN7 NM_002891.3 RASGRF1 NM_004556.1 NFKBIE NM_025216.2 WNT10A NM_030764.2 SPAP1 NM_001852.3 COL9A2 NM_001238.1 CCNE1 NM_025113.1 C13orf18 NM_002122.2 HLA-DQA1 AK055652.1 C3orf6 AL080130.1 FLJ14001 NM_000271.1 NPC1 NM_138340.3 ABHD3 NM_003332.2 TYROBP NM_004117.2 FKBP5 NM_001196.2 BID NM_015641.2 TES NM_012448.3 STAT5B NM_181443.1 BTBD3 NM_006254.3 PRKCD H57732.1 TGFBR2 NM_001154.2 ANXA5 NM_002467.2 MYC NM_004951.2 EBI2 NM_005935.1 MLLT2 NM_005415.3 SLC20A1 NM_000927.3 ABCB1 NM_000917.1 P4HA1 NM_004184.3 WARS NM_005601.3 NKG7 NM_006889.2 CD86 NM_032991.1 CASP3 NM_003810.2 TNFSF10 NM_001166.3 BIRC2 NM_004354.1 CCNG2 NM_003915.2 RBM12 U90916.1 SORL1 NM_005211.2 CSF1R NM_000397.2 CYBB NM_005213.2 CSTA NM_002051.2 GATA3 NM_001068.2 TOP2B NM_005013.1 NUCB2 NM_005638.3 SYBL1 NM_002838.2 PTPRC NM_006006.3 ZBTB16 NM_001110.1 ADAM10 NM_002306.1 LGALS3 NM_000627.2 LTBP1 NM_030666.2 SERPINB1 NM_002967.2 SAFB NM_003217.1 TEGT NM_018442.1 IQWD1 W56129.1 SFRS9 NM_002211.2 ITGB1 NM_000584.2 IL8 NM_000295.3 SERPINA1 NM_004049.2 BCL2A1 NM_002966.1 S100A10 NM_003299.1 TRA1 NM_000576.2 IL1B NM_006498.1 LGALS2 NM_000585.2 IL15 NM_001831.2 CLU NM_003656.3 CAMK1 NM_003254.1 TIMP1 NM_002305.2 LGALS1 NM_000579.1 CCR5 NM_001967.2 EIF4A2 NM_002943.2 RORA NM_004529.1 MLLT3 NM_006164.2 NFE2L2 NM_006332.3 IFI30 NM_006644.2 HSPH1 BI769730.1 HLA-DRB1 NM_005347.2 HSPA5 NM_000189.4 HK2

TABLE 16 An HCP set specific for TCL, according to one embodiment of the invention TCL Signature Accession No. Symbol NM_006274.2 CCL19 NM_005856.1 RAMP3 NM_004577.3 PSPH NM_004737.2 LARGE AF196185.1 PARD3 NM_017955.2 CDCA4 NM_014762.1 DHCR24 NM_006475.1 POSTN NM_004091.2 E2F2 NM_016076.2 PNAS-4 NM_078467.1 CDKN1A NM_002189.2 IL15RA NM_006841.3 SLC38A3 NM_002358.2 MAD2L1 NM_001254.2 CDC6 NM_000600.1 IL6 NM_002105.1 H2AFX NM_000269.2 NME1 NM_001826.1 CKS1B NM_001827.1 CKS2 NM_182746.1 MCM4 NM_000853.1 GSTT1 NM_007361.2 NID2 NM_004460.2 FAP NM_016081.2 KIAA0992 NM_003290.1 TPM4 NM_030775.2 WNT5B NM_004322.2 BAD NM_005623.2 CCL8 NM_006892.3 DNMT3B NM_005950.1 MT1G NM_080881.1 DBN1 NM_005951.1 MT1H NM_003254.1 TIMP1 NM_001353.4 AKR1C1 NM_002692.2 POLE2 NM_006014.2 DXS9879E NM_016336.2 UBE2J1 NM_002122.2 HLA-DQA1 NM_000075.2 CDK4 NM_004851.1 NAPSA AB014540.1 SWAP70 NM_015641.2 TES NM_015866.2 PRDM2 NM_014456.3 PDCD4 T66903.1 LOC54103 NM_139207.1 NAP1L1 H57732.1 TGFBR2 NM_003648.2 DGKD NM_005582.1 LY64 NM_003243.1 TGFBR3 NM_004951.2 EBI2 NM_005935.1 MLLT2 NM_003177.3 SYK NM_002002.3 FCER2 NM_002350.1 LYN NM_000655.2 SELL NM_005531.1 IFI16 NM_005077.3 TLE1 NM_003810.2 TNFSF10 NM_004354.1 CCNG2 NM_006162.3 NFATC1 U90916.1 SORL1 NM_000397.2 CYBB NM_021950.2 MS4A1 NM_175870.3 LOC90925 NM_005013.1 NUCB2 NM_021966.1 TCL1A NM_005127.2 CLECSF2 NM_002838.2 PTPRC NM_001781.1 CD69 NM_000627.2 LTBP1 NM_030666.2 SERPINB1 NM_001706.2 BCL6 NM_002967.2 SAFB NM_003217.1 TEGT NM_000061.1 BTK W56129.1 SFRS9 NM_004271.1 LY86 NM_002211.2 ITGB1 NM_000626.1 CD79B NM_023037.1 13CDNA73 NM_004510.2 SP110 AL833316.1 MIR NM_001967.2 EIF4A2 NM_006164.2 NFE2L2 NM_007360.1 KLRK1 NM_020151.2 STARD7 NM_021813.1 BACH2 NM_030764.2 SPAP1 BE897089.1 ZNF91 NM_017935.2 BANK1

TABLE 17 An HCP set specific for CLL, according to one embodiment of the invention GenBank ™ Symbol Accession No. BAIAP2L1 NM_018842.3 C3orf6 AK055652.1 CD74 NM_004355.1 CDCA7 NM_031942.3 CDKN3 NM_005192.2 CLIC5 NM_016184.2 CNN3 AL049313.1 COL1A2 NM_001839.2 CX3CR1 NM_000089.3 ENPP2 NM_001337.2 GATA3 NM_006209.2 HCK NM_002051.2 IGFBP7 NM_002110.2 ITGAL NM_001553.1 LGALS2 T28925.1 LGALS3 NM_006498.1 LOC54103 NM_002306.1 MT1H AI523104.1 NK4 T66903.1 NKG7 NM_005951.1 PLA2G7 NM_004221.3 PLAU NM_005601.3 PON2 NM_005084.2 PPBP NM_002658.1 PRKCD NM_000305.1 SPAP1 NM_002704.2 SPIB NM_006254.3 STAT1 NM_030764.2 TCF4 NM_003121.1 TLE1 AK022231.1 TNFSF10 AI307786.1 TRIP6 NM_005077.3 TYROBP NM_003810.2 CLECSF6 NM_003302.1 LILRB1 NM_003332.2 ANXA1 NM_000700.1 BCL2A1 NM_000484.2 CCNA2 NM_004049.2 CD24 NM_001237.2 CDC2 NM_013230.1 CSF3R NM_001786.2 ENTPD1 NM_156038.2 FN1 NM_001776.3 APP NM_212474.1 STMN1 NM_005531.1 IFI16 NM_001558.2 IL10RA NM_007360.1 KLRK1 NM_000237.1 LPL NM_002341.1 LTB NM_002358.2 MAD2L1 NM_021038.3 MBNL1 NM_002619.1 PF4 NM_002692.2 POLE2 NM_006115.3 PRAME NM_004577.3 PSPH NM_005608.1 PTPRCAP NM_015149.2 RGL1 NM_003821.4 RIPK2 NM_005621.1 S100A12 NM_006748.1 SLA U90916.1 SORL1 NM_005563.3 SWAP70 AB014540.1 TFRC NM_003234.1 TRAF1 NM_005658.2 ZAP70 NM_001079.3

TABLE 18 An HCP set specific for AML, according to one embodiment of the invention GenBank ™ Symbol Accession No. BIRC5 NM_001168.1 BZRP NM_007311.2 C13orf18 NM_025113.1 C3orf6 AK055652.1 CDC20 NM_001255.1 CDC6 NM_001254.2 CDCA7 NM_031942.3 CDKN3 NM_005192.2 CHEK1 NM_001274.2 CLIC5 AL049313.1 CSF1R NM_005211.2 DMD NM_000109.2 FGR NM_005248.1 HCK NM_002110.2 IL16 NM_004513.3 KNTC2 NM_006101.1 LGALS1 NM_002305.2 LGALS3 NM_002306.1 LILRB1 AI523104.1 NKG7 NM_005601.3 PCDH9 BC042366.1 PLA2G7 NM_005084.2 PLCG2 NM_002661.1 PON2 NM_000305.1 PPBP NM_002704.2 PRKCD NM_006254.3 PTPN6 NM_002831.3 PTPRC NM_002838.2 RAB13 NM_002870.2 RAG2 NM_000536.1 S100A6 NM_014624.2 SERPINA1 NM_000295.3 SFRS3 BE927772.1 SPAP1 NM_030764.2 SPIB NM_003121.1 TCF4 AI307786.1 TCF7 NM_201632.1 TIMP1 NM_003254.1 TLE1 NM_005077.3 AKAP12 AI672553.1 ANXA1 NM_000700.1 APOBEC3G NM_021822.1 ASPM NM_018136.2 AUTS2 NM_015570.1 BASP1 NM_006317.3 BCL2A1 NM_004049.2 BIRC3 NM_001165.3 BTK NM_000061.1 CASP4 AL050391.1 CCL5 NM_002985.2 CCNA2 NM_001237.2 CD2 NM_001767.2 CD24 NM_013230.1 CD36 NM_001001547.1 CD3D NM_000732.2 CD44 NM_000610.3 CD79B NM_000626.1 CD86 NM_006889.2 CDC2 NM_001786.2 CDCA1 NM_031423.2 CR2 NM_001877.2 CSF3R NM_156038.2 CSTA NM_005213.2 CTGF NM_001901.1 CX3CR1 NM_001337.2 CXCR4 NM_003467.1 DNTT NM_004088.2 EBI2 NM_004951.2 ENPP2 NM_006209.2 ENTPD1 NM_001776.3 FCER2 NM_002002.3 FLJ40504 NM_173624.1 GUCY1A3 NM_000856.1 HCLS1 NM_005335.3 HIST1H2AC BC050602.1 HIVEP2 NM_006734.2 HLA- NM_006120.2 DMA HLA- NM_033554.2 DPA1 HLA- NM_002121.4 DPB1 HLA- NM_019111.2 DRA IFI30 NM_006332.3 IFI44L NM_006820.1 IGJ NM_144646.2 IL10RA NM_001558.2 KIF2C NM_006845.2 KLRK1 NM_007360.1 KRT19 NM_002276.3 LCK NM_005356.2 LTB NM_002341.1 LY86 NM_004271.1 MAD2L1 NM_002358.2 MAL NM_022438.1 MBNL1 NM_021038.3 MGMT NM_002412.2 MS4A1 NM_021950.2 MT1G NM_005950.1 MYL4 W04885.1 NAPSA NM_004851.1 NCF4 NM_013416.2 P2RY5 NM_005767.3 PF4 NM_002619.1 PLAU NM_002658.1 POLE2 NM_002692.2 PRAME NM_006115.3 PSPH NM_004577.3 PTPRCAP NM_005608.1 RGL1 NM_015149.2 RIPK2 NM_003821.4 RNASE1 NM_198232.1 S100A12 NM_005621.1 S100A4 NM_002961.2 SAMHD1 NM_015474.2 SERPINB1 NM_030666.2 SERPING 1 NM_000062.1 SESN3 BU929213.1 SLA NM_006748.1 SLAMF1 NM_003037.1 SLC1A4 NM_003038.2 SORL1 U90916.1 STMN1 NM_005563.3 SWAP70 AB014540.1 TCL1A NM_021966.1 TFRC NM_003234.1 TOP2A NM_001067.2 TRIP6 NM_003302.1 TXNIP NM_006472.1 TYROBP NM_003332.2 VEGF BC058855.1 ZAP70 NM_001079.3

TABLE 19 An HCP set specific for T-ALL, according to one embodiment of the invention GenBank ™ Symbol Accession No. BIRC5 NM_002102.2 C13orf18 NM_001168.1 C3orf6 NM_001255.1 CD74 NM_006101.1 CDC20 NM_001254.2 CDC6 NM_001274.2 CHEK1 NM_000536.1 CLIC5 NM_004088.2 CSF1R NM_201632.1 DNTT NM_005601.3 FGR NM_002838.2 GYPE AL049313.1 IL16 AI307786.1 KNTC2 NM_000305.1 LILRB1 AK055652.1 NKG7 NM_002870.2 PCDH9 NM_025113.1 PLCG2 NM_002661.1 PON2 NM_003121.1 PTPRC NM_004513.3 RAB13 AI523104.1 RAG2 NM_004355.1 SERPINA1 BC042366.1 SPIB NM_005248.1 TCF4 NM_001242.3 TCF7 NM_005211.2 TNFRSF7 NM_000295.3 AKAP12 W04885.1 ANXA1 NM_013230.1 APP NM_173624.1 ASPM BC058855.1 AUTS2 NM_002358.2 BASP1 NM_018136.2 BCL2A1 NM_006845.2 BIRC3 NM_031966.2 BTK NM_001237.2 CASP4 NM_001067.2 CCL5 NM_003234.1 CCNA2 NM_001786.2 CCNB1 NM_002692.2 CD2 NM_004577.3 CD24 NM_022438.1 CD36 NM_006748.1 CD37 NM_004615.2 CD3D NM_000700.1 CD44 NM_000732.2 CD86 NM_003467.1 CDC2 NM_001767.2 CNN3 NM_005356.2 CSF3R NM_006734.2 CSTA NM_001079.3 CTGF NM_005608.1 CXCR4 NM_005531.1 EBI2 NM_012151.2 ENG AI672553.1 ENPP2 BU929213.1 ENTPD1 NM_005965.3 F8A1 NM_000237.1 FCER2 NM_001839.2 FLJ40504 NM_006209.2 FN1 NM_000062.1 HCK NM_212474.1 HCLS1 NM_001901.1 HIST1H2AC NM_003302.1 HIVEP2 NM_003821.4 HLA-DMA BC050602.1 HLA-DPA1 NM_015149.2 HLA-DPB1 NM_021966.1 HLA-DRA NM_002002.3 IFI16 NM_006317.3 IFI30 NM_006120.2 IFI44L NM_001774.1 IGJ NM_144646.2 IL10RA NM_021950.2 KIF2C NM_002341.1 KLRK1 NM_013416.2 LCK NM_005213.2 LPL NM_015570.1 LTB U90916.1 LY86 NM_004049.2 MAD2L1 NM_015474.2 MAL NM_004951.2 MBNL1 NM_003037.1 MS4A1 NM_156038.2 MYL4 NM_001776.3 MYLK NM_004851.1 NAPSA NM_000484.2 NCF4 NM_006820.1 POLE2 NM_000061.1 PSPH NM_002985.2 PTPRCAP NM_001558.2 RGL1 NM_000610.3 RIPK2 NM_004271.1 S100A12 AB014540.1 S100A4 NM_001165.3 SAMHD1 NM_006889.2 SERPING1 NM_002110.2 SESN3 NM_005335.3 SLA NM_007360.1 SLAMF1 NM_000118.1 SORL1 AL050391.1 SWAP70 NM_001001547.1 TCL1A NM_005621.1 TFRC NM_021038.3 TM4SF2 NM_006332.3 TOP2A NM_002961.2 TRIP6 NM_006472.1 TXNTP NM_003332.2 TYROBP NM_033554.2 VEGF NM_002121.4 ZAP70 NM_019111.2

1.2 Polynucleotide Probes

The system of the present invention provides for combinations of polynucleotide probes (hematological cancer profiling (HCP) combinations) that are capable of detecting the genes of one or more HCP set. Each polynucleotide probe of the HCP combination comprises a nucleotide sequence derived from the nucleotide sequence of a gene within an HCP set (the target gene). The nucleotide sequence of the polynucleotide probe is designed such that it corresponds to, or is complementary to, a region that is unique to the target gene, or mRNA transcribed from the gene.

The polynucleotide probe can specifically hybridize under either stringent or lowered stringency hybridization conditions to a region of the target gene, to a mRNA transcribed from the target gene, or to a nucleic acid sequence (such as a cDNA) derived therefrom. If splice variants of a gene are known, the probe may be designed such that it hybridises to only a single splice variant (for example, comprising a sequence complementary to a region of the mRNA unique to that splice variant), or it may be designed such that it hybridises to all splice variants (for example, comprising a sequence complementary to a region of the mRNA common to all splice variants). When splice-variant specific probes are used, several different probes may be designed, each one specific for a different splice-variant.

The selection of the polynucleotide probe sequences and determination of their uniqueness may be carried out in silico using techniques known in the art, for example, based on a BLASTN search of the polynucleotide sequence in question against gene sequence databases, such as the Human Genome Sequence, UniGene, dbEST or the non-redundant database at NCBI. In one embodiment of the invention, the polynucleotide probe is complementary to a region of a target mRNA derived from a target gene in the HCP set. Computer programs can also be employed to select probe sequences that will not cross hybridize or will not hybridize non-specifically.

One skilled in the art will understand that the nucleotide sequence of the polynucleotide probe need not be identical to its target sequence in order to specifically hybridise thereto. The polynucleotide probes of the present invention, therefore, comprise a nucleotide sequence that is at least about 75% identical to a region of the target gene or mRNA. In another embodiment, the nucleotide sequence of the polynucleotide probe is at least about 90% identical a region of the target gene or mRNA. In a further embodiment, the nucleotide sequence of the polynucleotide probe is at least about 95% identical to a region of the target gene or mRNA. Methods of determining sequence identity are known in the art and can be determined, for example, by using the BLASTN program of the University of Wisconsin Computer Group (GCG) software or provided on the NCBI website. The nucleotide sequence of the polynucleotide probes of the present invention may exhibit variability by differing (e.g. by nucleotide substitution, including transition or transversion) at one, two, three, four or more nucleotides from the sequence of the target gene.

Other criteria known in the art may be employed in the design of the polynucleotide probes of the present invention. For example, the probes can be designed to have <50% G content and/or between about 25% and about 70% G+C content. Strategies to optimize probe hybridization to the target nucleic acid sequence can also be included in the process of probe selection. Hybridization under particular pH, salt, and temperature conditions can be optimized by taking into account melting temperatures and by using empirical rules that correlate with desired hybridization behaviours. Computer models may be used for predicting the intensity and concentration-dependence of probe hybridization.

As is known in the art, in order to represent a unique sequence in the human genome, a probe should be at least 15 nucleotides in length. Accordingly, the polynucleotide probes of the present invention range in length from about 15 nucleotides to the full length of the target gene or target mRNA. In one embodiment of the invention, the polynucleotide probes are at least about 15 nucleotides in length. In another embodiment, the polynucleotide probes are at least about 20 nucleotides in length. In a further embodiment, the polynucleotide probes are at least about 25 nucleotides in length. In another embodiment, the polynucleotide probes are between about 15 nucleotides and about 500 nucleotides in length. In other embodiments, the polynucleotide probes are between about 15 nucleotides and about 450 nucleotides, about 15 nucleotides and about 400 nucleotides, about 15 nucleotides and about 350 nucleotides, about 15 nucleotides and about 300 nucleotides in length. Larger polynucleotide probes, for example, of about 525, 550, 575, 600, 625, 650, 675, or 700 nucleotides in length are also contemplated by the present invention. In further embodiments, the polynucleotide probes are between about 15 nucleotides and about 100 nucleotides, about 20 nucleotides and about 100 nucleotides, about 25 nucleotides and about 100 nucleotides, and about 25 nucleotides and about 75 nucleotides in length.

In one embodiment of the invention, each of the polynucleotide probes in an HCP combination comprises a sequence corresponding to or complementary to, the sequence of an mRNA transcribed from one of the genes listed in Table 1. Representative examples of suitable probe sequences include probes comprising all or a portion of one of the sequences as set forth in any one of SEQ ID NOs: 1-4530 (Tables 20-23, below). In one embodiment, the probes comprise at least 15 consecutive nucleotides of one of the sequences as set forth in SEQ ID NOs:1-4530 (Tables 20-23).

TABLE 20 30mer polynucleotide probes, according to one embodiment GenBank Accession SEQ ID NO: No. for target gene Symbol 30mer 1 AA594161 MYH11 tcgagacgcagacttcaatggaaccaaggc 2 AA766908 MME caaagttttatcaagtttgggtctgtgctg 3 AB014540 SWAP70 acctgttaaagggccaacagaactcttggt 4 AF196185 PARD3 tggtgttaccagtgtacgcgcagtgacctt 5 AI597616 MRPL33 ttcagaaaccctgtagcgtgtaataaaaga 6 AI634809 ARID5B ctacttgcttccttttagcttctgccttgc 7 AI672553 AKAP12 catggcatgaaataagtcaggttctttaca 8 AI809213 RGS13 gaaacccacaaaatcagaaacacagtacaa 9 AK022231 STAT1 agatggcgagaacctaagtttcagttgatt 10 AK022293 CTSD gtttgtatccaactccgggcaatgtggggc 11 AK055652 C3orf6 atgaccctaataggtctgtttagtaacagt 12 AL080130 FLJ14001 ccacctgaattgagcatttaggaatttatg 13 AL833316 MIR tgctatacactgggatgtctaattgcagca 14 AW291384 STS-1 gggctacaatccattgttcttagtccaata 15 BE897089 ZNF91 catttatatcatcctcaaccctaaatggac 16 BG993697 SMYD3 aagaaatgcctataaagacagacttgagtg 17 BI769730 HLA-DRB1 gtacgaggagcatacgccacacttatgatt 18 BQ632574 RASA1 aacttctgactacttgttgtatctgctgga 19 BX504817 SFRS7 tgttgcacttggttagctttaattgttctg 20 H53164 IRF8 gaacctcccagtgaaagggcagccttcatt 21 H57732 TGFBR2 tagacagagtacaaggtgtaattcagacag 22 L29376 3.8-1 atatgtataaaaacagtagtttgggggcct 23 M80899 ARNAK gtgtcggtgccaaaattggagggagattta 24 NM_000038 APC agatcagagggtgactgatgatacatgcat 25 NM_000043 FAS tactaactgctctcagagaaagtagctttg 26 NM_000061 BTK gtgggggtggaccgaatttggcaagaatga 27 NM_000075 CDK4 acactcgtgttcatgttggtgcgatcgggg 28 NM_000109 DMD aacaaggggttactttacatcctactaaga 29 NM_000189 HK2 cggggtgtgatgaatagcgaatcatctcaa 30 NM_000237 LPL caagaaagaaacgtacttaactgtgtgaag 31 NM_000269 NME1 cccgtcttaccgctagttccctgcatagca 32 NM_000271 NPC1 aaagaaagcatctcgtaggtgtgtctactg 33 NM_000295 SERPINA1 cccaaactaatctaggaatcactgtctaac 34 NM_000313 PROS1 cattcatagccagatgtgtatcagatgttt 35 NM_000397 CYBB caactaagttatgaaagtagagagatctgc 36 NM_000405 GM2A actatagaatcccatacacaacggaatcac 37 NM_000424 KRT5 tatccttttctggagagtagtctagaccaa 38 NM_000483 APOC2 cgaagcgtacggagcagtaagacacataag 39 NM_000576 IL1B attcgctcccacattctgatgagcaaccgc 40 NM_000579 CCR5 gagagtgcaacagtagcataggaccctacc 41 NM_000584 IL8 cagccaaaactccacagtcaatattagtaa 42 NM_000585 IL15 ggctctcattgacttccttactaagcatag 43 NM_000600 IL6 cagtacacccgcccgttcttactgctaaaa 44 NM_000626 CD79B cgtggaataaacggtgtgtcctgagaaacc 45 NM_000627 LTBP1 gatgatccccaatatatctaccattgtatg 46 NM_000633 BCL2 caccattagctataatggcactttgtttgt 47 NM_000655 SELL gtttccttttatgagacccattcctatttc 48 NM_000713 BLVRB agagagagtagcgtgcggactagcaacgca 49 NM_000785 CYP27B1 tctgccctagcctggtttacggtttcttat 50 NM_000788 DCK gtggaattaaaggaatccctagaataagga 51 NM_000853 GSTT1 gtggtgcactcctataaaaattgaagctgc 52 NM_000877 IL1R1 agcatgcatcacggatcaatagactgtact 53 NM_000917 P4HA1 tacgttgtcagaattggaatgacaaacagg 54 NM_000927 ABCB1 actttcatgtgactggagtcatcttgtcca 55 NM_001067 TOP2A cagcaatgagctattagattcattttggga 56 NM_001068 TOP2B atctttggtgaccctctcggttctgcttct 57 NM_001110 ADAM10 tttcttacgtacactgtacttctgtgtgca 58 NM_001154 ANXA5 cctggatgttaaacagatcaatctcactcc 59 NM_001166 BIRC2 tctcttatttctccccctagtttgtgagaa 60 NM_001196 BID ctgcctgctgtaagaccatcctctatggtt 61 NM_001230 CASP10 agtcctgtggttaacgccttcatttataga 62 NM_001238 CCNE1 acattatcagttgacagtgtacaatgcctt 63 NM_001242 TNFRSF7 gagtgttgtggccgtgaggacttttctgtc 64 NM_001254 CDC6 cataaggagactataactctacagattgtg 65 NM_001350 DAXX agggatggactaagctaatccccttttggt 66 NM_001425 EMP3 atagatcttgttcccccccgcacctttccc 67 NM_001552 IGFBP4 gaaggagacttaggaacctaccagttggcc 68 NM_001558 IL10RA atgtgccttgaacacaaagctctgtcaata 69 NM_001618 PARP1 gaaggaacgctaacaatttctcatacttag 70 NM_001621 AHR gatttagaccagaggtctagattaatactc 71 NM_001647 APOD taacagggtagggcatggttacatgtttag 72 NM_001663 ARF6 attattgaatgttgcaggtgagatgtggtt 73 NM_001706 BCL6 gcgtcatgcttgtgttataactactccgga 74 NM_001760 CCND3 ggaccatcatcctactgtaataaagatgat 75 NM_001762 CCT6A cacccaaattacgtttccacgagattattt 76 NM_001770 CD19 atctgaagacctcgagcagatgatgccaac 77 NM_001771 CD22 agacgtacgtatcagcggccccttgactct 78 NM_001779 CD58 gaataggagggtaattaagactcctggtct 79 NM_001781 CD69 tgtagacaggtccttttcgatggtacatat 80 NM_001782 CD72 ccccccaagaacttcccatggtagaatggg 81 NM_001826 CKS1B gatgaaacccctgcacactattgtcagtaa 82 NM_001827 CKS2 cataaaataatcgttccccggattctctca 83 NM_001831 CLU ggtcagaggtatttgcttaagtgatcataa 84 NM_001852 COL9A2 cttctctttctcgcataactccccacccct 85 NM_001853 COL9A3 cagattaatgactggctacagagtaacaaa 86 NM_001877 CR2 cactcagtgattgcaatttgcacaagtttt 87 NM_001888 CRYM aaagcaaagctaggtagccatttcttctgt 88 NM_001894 CSNK1E ctgggttttggattaacccatccttcctag 89 NM_001951 E2F5 aaaatgtgccaatgcctgtacattaacaga 90 NM_001967 EIF4A2 gcctgtaaccttacagtgtattcctaataa 91 NM_002002 FCER2 tgagtatccccagctcaggtggtgagtcct 92 NM_002051 GATA3 gatcactgcctttaatacagtctgttggaa 93 NM_002095 GTF2E2 gtttgcccatagtcttgaatgcaatatttg 94 NM_002101 GYPC actgagcatacccagtgggccaacaagcac 95 NM_002105 H2AFX gttccacccaagccaatttcagacccttcg 96 NM_002120 HLA-DOB agacaaatgctcaggtagtcactgtttcct 97 NM_002122 HLA-DQA1 agccacccggctacctaattcctcagtaac 98 NM_002155 HSPA6 gtcagggctatgctatgggccttctagact 99 NM_002189 IL15RA cagcgtttgggcttctaaccaccctgtctc 100 NM_002211 ITGB1 cactagtcacattcttgttttaagtgcctt 101 NM_002217 ITIH3 ggatggatggcccggattttatggcatctg 102 NM_002250 KCNN4 ttacaagtgcaggcgactggaggcaggact 103 NM_002305 LGALS1 ggagacttcaagattaagtgcgtggccttt 104 NM_002350 LYN tcaagcggttctgttcactaaatttttctc 105 NM_002358 MAD2L1 tgtcgacccacaatcactcacggcgcgtaa 106 NM_002426 MMP12 gtccattcttgcttgactctactattaagt 107 NM_002467 MYC ctcaaattggactttgggcataaaagaact 108 NM_002526 NT5E ggccagtaaaatagggtaaatcctattaga 109 NM_002567 PBP tgacgagaagagctagtaatcacctgcaca 110 NM_002646 PIK3C2B tgctcctgatttaaagagatctgtgtactg 111 NM_002661 PLCG2 aactggcatgagttggggtaatttcctatt 112 NM_002692 POLE2 tcactacgacaaataccgaatgcctctgca 113 NM_002738 PRKCB1 agttactgtgaactattgtctcttggagga 114 NM_002752 MAPK9 ctgcttctgaagttatctcttaatcctctt 115 NM_002832 PTPN7 acgactgtctatgccaatgaggctcggtgg 116 NM_002838 PTPRC gcatgctcgattattccctgtacaatattt 117 NM_002891 RASGRF1 tgaatttctgcaccgtttcagacttcgccc 118 NM_002892 ARID4A tgcccaggattgaaggtgtaaatgggacaa 119 NM_002943 RORA gtcatggtattcttcattactgtgcagttg 120 NM_002966 S100A10 gtccacttaccacccactttgtgtttcctt 121 NM_002967 SAFB gttctgttaggagttaccttaaactgtgta 122 NM_003037 SLAMF1 cctaggttcagatcttaacttggccactta 123 NM_003088 FSCN1 ctaaacgcccatgatagtagcttcaaactg 124 NM_003177 SYK cccaaggatgccttagcatgtgactcctga 125 NM_003217 TEGT cctgttaactctccataaatttggtgattc 126 NM_003226 TFF3 ggtggccacacataagctcatcagcataga 127 NM_003243 TGFBR3 aaagggcactcatttggattgccttacttc 128 NM_003254 TIMP1 gatctcataacgctggtataaggtggtctg 129 NM_003290 TPM4 cttggttatcctcttccaatgtgaggacac 130 NM_003299 TRA1 ttgttttggatgccccctaatccccttctc 131 NM_003332 TYROBP cccaatactctcctaaaataaacatgaagc 132 NM_003362 UNG gagttggctctacgcgaggtttgttaataa 133 NM_003451 ZNF177 ttaaaccactcttgtgggaagttcctcttt 134 NM_003648 DGKD ggtggggcttaccccctcgtatttataatc 135 NM_003656 CAMK1 tggcccccactctcatagatgtcatccagg 136 NM_003810 TNFSF10 actaaaagatcgcagtttgcctggtgcagt 137 NM_003875 GMPS caacacctggcaatgagatccctgtagagg 138 NM_003959 HIP1R aggaatgtcgcccattactcctcaggcctg 139 NM_004049 BCL2A1 gttgcggagttcataatgaataacacagga 140 NM_004073 PLK3 ccagctagggggcgttatttatggaccact 141 NM_004091 E2F2 ttatgagcaccatgtaagcctccttgtatt 142 NM_004117 FKBP5 aggctgcatatggattgccaagtcagcata 143 NM_004126 GNG11 tcacccaagagccataatacacctattata 144 NM_004184 WARS caggcctcatttcatcacgcagcatgtgca 145 NM_004271 LY86 gagatcaccgacatcatgacacagacacac 146 NM_004289 NFE2L3 aagatcacacttgtgggcaatctgggggag 147 NM_004322 BAD gagtccacaaactcgtcactcatcctccgg 148 NM_004354 CCNG2 cagtaatagataagtgagacagattgcttg 149 NM_004356 CD81 acaacatcctgactccgtcatttaataaag 150 NM_004358 CDC25B gggagcgttttgttgagcatgacagcctgc 151 NM_004422 DVL2 atccattgggccccttctaaccccagaatg 152 NM_004445 EPHB6 tgagaatgacgatacccgtgactcagccct 153 NM_004510 SP110 gttcagatcagataaagcttcttcgggctg 154 NM_004529 MLLT3 agaaggatttcttgtattggtgaaagacgg 155 NM_004556 NFKBIE ggtcacccctatgctggcatgaagagcatg 156 NM_004577 PSPH tcttagaaatacggattcggcagccttcag 157 NM_004619 TRAF5 agccttacgggagcacatgcgtttggtttt 158 NM_004635 MAPKAPK3 atgtcagataggacaacactgctgggtttt 159 NM_004737 LARGE agttgcaatgtgaccagcgaaagctgcatt 160 NM_004844 SH3BP5 tttccctaactccagttattctgctgctgc 161 NM_004851 NAPSA cgcggaggtcctgctacccagtaaaaatcc 162 NM_004951 EBI2 tttggaataaagagcaggatgctgcaaagt 163 NM_005013 NUCB2 aatatcatcaggtcatacagcagatggaac 164 NM_005077 TLE1 ttccttgcagttcacctcactttccgtcct 165 NM_005127 CLECSF2 cctcaaaactttactagggccaataaactt 166 NM_005211 CSF1R agtcacgccgtgggatgtctctgtccacat 167 NM_005213 CSTA caggtatcattttggctgattgcttctttg 168 NM_005214 CTLA4 ggcccaattcttacaaacatgtggttaatg 169 NM_005271 GLUD1 acagtagtgtccccatgaagtgctagataa 170 NM_005292 GPR18 cactaactactctggcgtcaatggatattc 171 NM_005347 HSPA5 ccacctagtctgtaactctttctgaggagc 172 NM_005348 HSPCA taaaagcctacctaagcatatcgtaaagct 173 NM_005415 SLC20A1 ccatgttcatttgtctacctcttaactgaa 174 NM_005449 TOSO gaacgtctacttatctcaagttctatgcta 175 NM_005461 MAFB gttgaaatcaaacctgccgcaacagaaatt 176 NM_005531 IFI16 caccatatatactagctgttaatcctatgg 177 NM_005582 LY64 catcagcccccacaatttgtcagagctgaa 178 NM_005601 NKG7 agctaccaccctcgtatttatcatacacac 179 NM_005606 LGMN ttttattgaagagggccgcaagccccaaat 180 NM_005610 RBBP4 tctctagcccactttatatcctgccaccag 181 NM_005623 CCL8 ctttggcaatcagtgctcctgtaagtcaaa 182 NM_005638 SYBL1 tgacatagatcttaggcccacttgaactct 183 NM_005652 TERF2 tgttcgtgtcttgcactggaattcaacatt 184 NM_005658 TRAF1 tggtaaccctgggcctattgaaagcaggat 185 NM_005856 RAMP3 tcatgatgctgtgcccgctatgggctgtgt 186 NM_005935 MLLT2 tgattttgtacatagggtagggaagcagtg 187 NM_005950 MT1G cacataccagcaccactactcacactacag 188 NM_005951 MT1H gcgaggaacacgcacacgttctgtgcaaac 189 NM_006006 ZBTB16 agagaagacgtacctctacctgtgctatgt 190 NM_006014 DXS9879E atatacgcgaatgaggcgccctatacccgc 191 NM_006115 PRAME tgttgacttgaggagttaatgtgatctttg 192 NM_006162 NFATC1 gtgcagcctttctcaggggactgtcattga 193 NM_006164 NFE2L2 tttgcctgtcacgtttgagtgttcctgggc 194 NM_006195 PBX3 acttactacctctgaacaatactcacgctg 195 NM_006218 PIK3CA cagggtttgatagcacttaaactagttcat 196 NM_006254 PRKCD tggaccagtctgcattcgctggcttctcct 197 NM_006257 PRXCQ aagatcaatggcccatgcatgctgtttgca 198 NM_006274 CCL19 gccgcagcagttaacctatgaccgtgcaga 199 NM_006317 BASP1 ttctcatgacgagttaatgcatgtccgtgg 200 NM_006332 IFI30 aaattccaccccatgatcaagaatcctgct 201 NM_006475 POSTN acataaaatgcacgcaagccattatctctc 202 NM_006498 LGALS2 aactggcttacgctgttggcacatttcctt 203 NM_006558 KHDRBS3 gattgacttacatactacagcacatgtact 204 NM_006620 HBS1L tattgaggaattctcatagctctgccttat 205 NM_006644 HSPH1 gtctgtagtctttatgatcctaaaagggaa 206 NM_006734 HIVEP2 acagagggtcgcacttggactctgagggtt 207 NM_006761 YWHAE ggtttggggagggacttcgttgtaatggtt 208 NM_006763 BTG2 ggaagaatgtacagcttatggacaaatgta 209 NM_006841 SLC38A3 tgaggtgacacagcctgtaggaacatacac 210 NM_006889 CD86 gccttgattagactcctagcacctggctag 211 NM_006892 DNMT3B cggatgcctagagtttaccttatgtttaat 212 NM_006986 MAGED1 tagagagccacatcctgttgactgaaagtg 213 NM_007311 BZRP ttctgcatgcttagagcatgttcttggaac 214 NM_007360 KLRK1 atttgtacttgcttgagtcccatgactgtt 215 NM_007361 NID2 tcctgtagtgcctctatagaagtacccaca 216 NM_012203 GRHPR ggacacatttgcgccaaaagtatggtaatt 217 NM_012448 STAT5B tcctatgcagagttacagtcacaaagttgt 218 NM_012452 TNFRSF13B cagtgcagctgtaggtcgtcatcacctaac 219 NM_013230 CD24 aatgaacactcttgctttattccagaatgc 220 NM_014246 CELSR1 agacctcttgatgttttcccactggtccct 221 NM_014257 CD209L tgcatttagggggcgggcttggtatgttgt 222 NM_014338 PISD ttgattcagggtctgtcttggaggcagagg 223 NM_014456 PDCD4 gttaagtaaaaggtggctggaacatctatt 224 NM_014686 KIAA0355 agactgtgtgaagccgtttgtgtggtctcc 225 NM_014762 DHCR24 gttttggatggagttaaacttgatgccagt 226 NM_015187 KIAA0746 tgcaatattgtgggtccaaactactctttg 227 NM_015641 TES gtccatggatatatcaaatgtcttcacttg 228 NM_015866 PRDM2 ccttcaacgctcccagacggtcaggaaaac 229 NM_016076 PNAS-4 gatatagcattgggctatcatgttacaaca 230 NM_016081 KIAA0992 tgctgggtttgggattaactagcattattt 231 NM_016187 BIN2 tctgtctttgacttacgacccattttgcaa 232 NM_016336 UBE2J1 agttgccttcagaactagtttgagctgctc 233 NM_016628 WAC gatttcttgtagatgtatccttcacgttgt 234 NM_017530 LOC55565 gtgggctctacgtcgacagaatgagccttt 235 NM_017784 OSBPL10 ttttagcctttacacatgaggtcaaaggag 236 NM_017935 BANK1 ccagtcattattgttacatcatgtttgcag 237 NM_017955 CDCA4 atcctcatggaccctagtttaaagggtatg 238 NM_018442 IQWD1 attttccctaaccttcaaatgtgggagctt 239 NM_018842 BAIAP2L1 ttctctgtttcacgtagttgggttgacaag 240 NM_020151 STARD7 gtctgtacagttactcatgtcattgtaatg 241 NM_020199 C5orf15 tcttgggcggacagtgtactttcctaatag 242 NM_020529 NFKBIA tacacttgtatgtggccgtccacggcagca 243 NM_020992 PDLIM1 aacccaatcaaatataacgtgtctgacact 244 NM_021813 BACH2 gcattgctatgaactaatggaattggaact 245 NM_021822 APOBEC3G caatttgaatcggttttgtaggtagaggaa 246 NM_021950 MS4A1 ctctaaatagccaacacccatctgtttttt 247 NM_021966 TCL1A actctgctcgccttagcactaccactcctg 248 NM_022552 DNMT3A tctcactttagccaattcgagggctccttg 249 NM_023037 13CDNA73 tgaaaagggaattgtaaatggactgcaatg 250 NM_024708 ASB7 ttttgtaccctggtggtcgagtcttccctt 251 NM_025113 C13orf18 gtgaactgtaactgacaagatgaattactc 252 NM_025216 WNT10A gcgagacacaacacttgtcctcttggaggt 253 NM_030666 SERPINB1 aagacaagcttgcctcgcctgacttttctg 254 NM_030764 SPAP1 ctgaacctgcaatatcaccaaagtatgcat 255 NM_030775 WNT5B tctgccccaggtgtacggtttctctctgac 256 NM_031305 ARHGAP24 tgggttcaaatggtatacaatttgccagct 257 NM_031942 CDCA7 gaccttgaatcgataagtgtaaatacagct 258 NM_032991 CASP3 gctcaaaaaatgagctcgcatttgtcaatg 259 NM_033208 TIGD7 cagagattccacttcacactgaaagagatg 260 NM_033274 ADAM19 ttatttgggagattgttcacggaaaacaga 261 NM_057735 CCNE2 cttgctgtacataggctagctatttctaaa 262 NM_078467 CDKN1A ttctccacctagactgtaaacctctcgagg 263 NM_079421 CDKN2D tccagtctcttgtacagcgttttaaaagaa 264 NM_080593 HIST1H2BK tgttccgatagtgtctcgcgggcgaaacca 265 NM_138340 ABHD3 ccagtattgtgtctaaattctgtggatgat 266 NM_138379 TIMD4 tgactattaacggcgggcgaaacgaaaata 267 NM_139207 NAP1L1 agttttaagggacgtcagtgtttatgccat 268 NM_139276 STAT3 cccgtgggttgcttacctacctataaggtg 269 NM_144646 IGJ taagtcattgctgactgcatagctcttttt 270 NM_145804 ABTB2 ctgacacctgtcatatttatggaccagaca 271 NM_152785 GCET2 ggactaagacactacccatataattcccag 272 NM_172373 ELF1 cttgggctaatctggctgagtagtcagtta 273 NM_173624 FLJ40504 caaatctcatgaccttgccaaaatcttggc 274 NM_175870 LOC90925 cccgcggagtaacctggcgacatatttaga 275 NM_177968 PPM1B ctgtactgatagtacttcccagtatgatat 276 NM_181443 BTBD3 cagctaattcaagacactgtagtcacttgt 277 NM_181838 UBE2D2 tttcctaattgtaaactaggccaacctgaa 278 NM_182746 MCM4 acctcattggtaaagggctagagcctttct 279 NM_182776 MCM7 ctgcacttactccttttgctaataaaagtg 280 NM_198833 SERPINB8 ctcctgtcactcagtacaattattttgaga 281 NM_201593 CACNB2 caaaggtaactaggaaagcattcatctgct 282 R99527 MGC39372 tcgtctctgtagtgatgacttcctgtcctc 283 T66903 LOC54103 atttgcagcagggtttgtctttgtgaattc 284 U37028 ITGAD agaagaagacgaggtctacaatgccattcc 285 W56129 SFRS9 actgtgactgagtcggcccattctgtttag 286 X58529 IGHM tgggagtggtcgattatgtactactttgac 287 AA188785 LOC286025 aatgcagtatagttaaaatggcttcccaca 288 AA347638 BCR gaagggaacgtgaccggattccctcactgt 289 AA601122 SECTM1 aataaggttccgtccgcgtgctgggtcaga 290 AA642467 SLC2A14 gttctggtcaatcatgttgaaagcctcctt 291 AA682722 LARP tcatagaaggctctggtggtacctctgggc 292 AA757235 LOC399933 ccaactctgtggcataacctcaaagccata 293 AA765313 FZD3 ttgggttacttcagatgcctaacaccttcc 294 AB002310 HUWE1 gctatccaggagtgctctgaaggctttggg 295 AB002333 ZNF518 gctttgtgctccagatattctagttggaac 296 AB0244O2 ING1 cccaccatctgtttgaagattatatgaagt 297 AB028952 SYNPO agccttgagaaaccggcagttcccaagcca 298 AB032991 NDFIP2 tgtgaaattaggttggggttgcaacatctt 299 AF008915 EVI5 agtttttacatcacatccattgatctgcct 300 AF108138 C15orf20 acagagaacggaacttaggtgtgtctctac 301 AF116668 LMO2 tgactttgacgcttgcgaactagagatgtg 302 AF143327 FLJ32810 gctacagtggatctattcaaagcttaactt 303 AF200348 D2S448 gctgtaacaggagtggaatgtacatattta 304 AF245480 MONDOA cttcaaaatgctgacgctttggagagtaag 305 AO075159 SPTA1 agctattttgtatgcaactagtcactgctg 306 BU948323 TCF4 agcacaaaaatttagtctgctggctgactg 307 AI523104 LILRB1 tttcctataagaaatttagggcagggcacg 308 AI675029 C7 ctctgtattgttctgaccctggtaaatata 309 AI694012 PSMA5 tagtaaaaagtaataattaggcccaggcac 310 AI732248 COL4A1 gctagtattgccacagacgcattaaaagaa 311 AJ007509 HNRPUL1 cttccccttgactcatatgttttaacatga 312 AK022224 ACTN1 gtttgctagctcacttgtccatgaaaatat 313 AK023928 PSCD1 tggatgcattttgtggtgggccccctagag 314 AK024580 NRP1 gtttcaaaatgaacagcgaagccttaactt 315 AK025005 MARCH1 ctagtataccctgtcaatacaactttcatc 316 AK091853 COL3A1 actttgtaagcttgtatgtggttgttgatc 317 AK126650 CAPZB acatttccatagagaccgtgtggtttttgt 318 AK127124 ARHGEF4 ttagggaggagtgcctactacccaaagaaa 319 AK127132 DRG1 agaaacaggatgccccagtaaacatgattt 320 AK129940 GNAI1 tggtaagtagtttccaagttacgtgttgtc 321 AL049313 CLIC5 tttcctacaatctgactcaactgccaggtg 322 AL049327 CBLB ttgcttagatgatgacgttgtggattcatt 323 AL049449 GAB1 gatcaggtttagacaatgagctttggttgt 324 AL050391 CASP4 gcaccttcattagtacagcttgcatattta 325 AL137527 LRCH3 ttgctttcaccctgcggtattgttttccct 326 AL353942 SEPT11 atatcactagtgccaagacataaagcgggg 327 AL833915 TDRD9 gtgtctgggtgttacagtctgtgcccactg 328 AL834278 USP30 atagctgtgcaaagccttttaacctgactt 329 AU252485 MAP7 tggttgaactgctaggttgaatgagagact 330 AV650179 PRG1 gaaaaagctcccacagtatgtggcgtctga 331 AV686223 KIAA1407 cactcagtttgtcttctagtactcagctca 332 AW014009 MAP2K3 cgagccatttgtcccaagtgccaaagaagc 333 AW190768 SLC13A3 ctggggattccacagagttgacctctctga 334 AW292143 GFAP atgtacccagtattctaggtagtgccctat 335 AW439398 CCND1 cagcaccaacatgtaaccggcatgtttcca 336 AW452039 HRMT1L3 ccaaatgtaactcccacattgagtttatct 337 AW615076 LOC4923O4 aaggttcctcaattttgcgaaaggggcaac 338 AW664012 ALOX5 taagacttagaataaggaggtggggaatgt 339 AW967479 CD38 agaaacaacgcaaccgacgacgcacaacgc 340 AW970654 PHTF2 aactgttgtttctttgccacatgtgttgta 341 BC028066 NALP1 agcgctctaaccctgcatattatttacttg 342 BC034289 LOC87769 tggaataaatgacgacgtaaacgtagctgc 343 BC042366 PCDH9 ggggtgtttgatgactttgacagaataaat 344 BC045532 LSM8 catttccctgcttaccatagggattttaaa 345 BC050383 TMPO ccagcacacaattttgatttcaattagcct 346 BC050602 HIST1H2AC catgtgtatgaattgttggtgctctaaaga 347 BC058855 VEGF gcagtttttcgagatattccgtagtacata 348 BE147267 ECE1 ccatgtctatctcaggggcccgttacctct 349 BE549606 BZW1 ttaacaagttaatcaggcgctacaaatacc 350 BE798965 LAMC1 aattccaactgtggaccttttatatgtgcc 351 BE927772 SFRS3 ggtacattgtagagccgaactttgagttac 352 BF055235 RIPK1 ttactacttggccaccacgcagccttggct 353 BF513638 WNT3 acctgaggcttatctttgcacatgttaaag 354 BF848289 CSDA tgtggaagggagtcgttacgctgcagatcg 355 BG682263 HDAC3 atgaacgggtagacaaggactgagattgcc 356 BG683220 PMS2 cactgctggatgttgaaggtaacttaataa 357 BG747999 MT1L gagaatacaacaacgatgcggcacgaggaa 358 B1493513 PHF8 cctccctttcctatagagataaaagtgatt 359 B1559738 GPR56 atcagctgttgtaatcacctagcaaactgg 360 BM709325 BCL7A ccatcagtagatatggtttgtacaatgtac 361 BM711190 MED28 cacccatgagaattagacattattctcctt 362 BM727177 GOLT1B gtcttacctctcaataaaagggtacttttc 363 BQ009245 GPM6B gtggaaatagttgtggatgtactaagagta 364 BQ021469 AGPS ttagtgacccactgaccgtatttgaacaaa 365 BQ215285 LEF1 ctttgctagctaacctgactccgggtgagg 366 BQ898221 ITGA6 tttcgtaacacagcattgtatatgtgaagc 367 BU929213 SESN3 tgactaaagctgacctaaatggatcagttt 368 BU954396 RPL11 gggatcatccttcctggcaaataaattccc 369 BX095432 CNTN5 ttgatcgttggtgggttgctagcctttcag 370 BX640908 EVI1 tcagtgcattactatgggaggagcaactaa 371 BX648339 USP53 ccaactacttttcatgaagagtgctttgaa 372 BX648365 SEPT7 accaacctgtttctacctatatgcagtctc 373 BX649193 TKT ctgagaggaggggtaaatatatgttttgag 374 C05886 ETV6 cctgcaaaccagaacgactctagaatttcc 375 D31762 TRAM2 gacagtaaatataataccgctgtttccttg 376 D86967 EDEM1 attaccttagccacagggtggctgagcagg 377 H41942 NPEPPS tggtgtggcttaacggtatttcagaaggtc 378 M60028 HLA-DQB1 acacttttgatattagcccccgcgggaccc 379 M77810 GATA2 cctctctgaaatagccgaactccaggctgg 380 N26272 MSI2 aggataccagaccactgtaatcaataagaa 381 N28431 COL6A1 gatgtgttcgacgttttatcaaaggccccc 382 N41620 WWP1 caggtgcttgaacttgtcagtttgttttaa 383 N53163 COL27A1 ctggaagttggacctgcgtgcttcctctga 384 N54946 EWSR1 gcagagatcggccctactagatgcagagac 385 N70000 UBE3B cttatggattgagatgtgatcaaaggcttt 386 NM_000016 ACADM aaagacttattgtagcccgtgaacacattg 387 NM_000022 ADA atatccacgtcacggatgcttccatgcccg 388 NM_000024 ADRB2 tcccgagcaaaggtctaaagtttacagtaa 389 NM_000033 ABCD1 ttccgtgggatgccataaaagccgcccagt 390 NM_000062 SERPING1 catggccctgccatgctctccaaaccactt 391 NM_000089 COL1A2 ctgtattgagttgtatcgtgtggtgtattt 392 NM_000099 CST3 ctcaaataggccagaacaactcactaatta 393 NM_000110 DPYD gaacaaagctcaaagtatgcaatgcttcat 394 NM_000118 ENG gaacttgcctaactaactggcaggggagac 395 NM_000120 EPHX1 ccaactccgtgtggtaagcaacatggcttt 396 NM_000147 FUCA1 gccaaaattcgctatgtttacagtgatact 397 NM_000169 GLA aggaagctagggttctatgaatggacttca 398 NM_000182 HADHA accacggtgtaccgggatattaaacctctt 399 NM_000194 HPRT1 ttaccagtgaatctttgtcagcagttccct 400 NM_000214 JAG1 gattcccttgttattcaacagcaagtgtga 401 NM_000234 LIG1 tggacggaccccagggttattattgccttt 402 NM_000239 LYZ atagatcttaggcaaaataccagctgatga 403 NM_000246 MHC2TA aatcgtgacaacacttgtgttatgaagcat 404 NM_000249 MLH1 gttggtagcacttaagacttatacttgcct 405 NM_000251 MSH2 agcatgtaatagagtgtgctaaacagaaag 406 NM_000277 PAH gcataatggtaaatcttttggggtcatctt 407 NM_000305 PON2 tttattccagtaaggaacggcccttttagt 408 NM_000314 PTEN atgatgcacttattcaatagctgtcagccg 409 NM_000341 SLC3A1 cttgaatgtaaccgctttaagaaaggttct 410 NM_000361 THBD tcattaaatggggctcacaaaccatgcaaa 411 NM_000382 ALDH3A2 caatcctttgatcataaattctccccaact 412 NM_000395 CSF2RB cataagtggttaagcaagtattctcgttac 413 NM_000417 IL2RA acactggtagaacgtaaccacggaaaagag 414 NM_000418 IL4R ggttgagtaatgctcgtctgtgtgttttag 415 NM_000435 NOTCH3 agccttatggcagaatagaggtatttttag 416 NM_000448 RAG1 ataagaggcaggatatataagcgccagtga 417 NM_000484 APP gaatgattggcttgagatagattggtggaa 418 NM_000485 APRT tggatcccagggaaatatcagccttgggca 419 NM_000536 RAG2 ttggattatgcccatgaacaagttagtttc 420 NM_000545 TCF1 cttcagtgtaccgcgtctaccctgggattc 421 NM_000546 TP53 tgacaacctcttggtcgaccttagtaccta 422 NM_000561 GSTM1 tgagacgcacacacattctaacctcccgcc 423 NM_000574 DAF ctgaatcgagatgtccatagtcaaatttgt 424 NM_000578 SLC11A1 tgcggagcctgtaataattgagggacaggc 425 NM_000594 TNF ccctactattcagtggcgagaaataaagtt 426 NM_000598 IGFBP3 acacacgctgcatagagctctccttgaaaa 427 NM_000601 HGF catgcaagtgtaataacatatctcctgaag 428 NM_000604 FGFR1 ttttaaaagggtcgttaccagagatttacc 429 NM_000610 CD44 cctgggctaagtcatttaaactgggtcttt 430 NM_000628 IL10RB ccctggacttagccaccagagagctacatt 431 NM_000629 IFNAR1 ctttcaggattagttcgttccaaggaggct 432 NM_000640 IL13RA2 actcaacagtttccagtcatggccaaatgt 433 NM_000660 TGFB1 cattaatgaactcattcagtcaccatagca 434 NM_000700 ANXA1 atcaggattatggtttcccgttctgaaatt 435 NM_000701 ATP1A1 gtaaaaaaggaacacccggaaagactgaaa 436 NM_000717 CA4 gggactttaggcatgattaaaatatggaca 437 NM_000729 CCK tgagaggcagctgcgtttctgcaacctatg 438 NM_000732 CD3D ctgagagggacattactgatgggagtgagg 439 NM_000773 CYP2E1 gttacaaactctgtgtcattccccgctcat 440 NM_000778 CYP4A11 aacctggttttttcccgtgtgaggaatgcc 441 NM_000791 DHFR acccatgaaggtaactaacggaaggaaaaa 442 NM_000801 FKBP1A agagcgagccgaacacaaaggagacgaaca 443 NM_000852 GSTP1 actcacacgtatggaatacccctgcacgcg 444 NM_000856 GUCY1A3 gagttttttgtacgattcctgcaacttttc 445 NM_000867 HTR2B tagttatgtatagcagaactggcagttgtc 446 NM_000878 IL2RB ttaatgatccgtgtgtaccatctttgtgat 447 NM_000885 ITGA4 cgagtggaccattatcactttaaagccctt 448 NM_000887 ITGAX cgatttcccaggctgaattgggagtgagat 449 NM_000905 NPY cgaaaacgcctgacacgaagagcgagacaa 450 NM_000906 NPR1 gaaaagagactaggtgaagagagggcaggg 451 NM_000953 PTGDR ggcatacaaggagtatgatttaacagtatg 452 NM_000960 PTGIR tgatgacgtaggacatgtgcttggtacaaa 453 NM_000964 RARA gctaatgaagattactgacctgcgaagcat 454 NM_000967 RPL3 ggtggtcttgatgccttaggcctctcttgt 455 NM_000968 RPL4 tcttgcgtggtgctcgaagggctctttgga 456 NM_000970 RPL6 aagagagtggtgccgtccgacaaaacacgg 457 NM_000972 RPL7A gccaaacagaattaacgcaactaataacct 458 NM_001001547 CD36 cctgcatataccaatagcattacctatgac 459 NM_001005 RPS3 aaggagagcaggtagagcgaagcagacgag 460 NM_001009 RPS5 catagagactaactagcggggagaggagca 461 NM_001015 RPS11 catatattcatgtgtcatcgttcaggaaca 462 NM_001019 RPS15A gcactatgttgaactattaaacttaccagc 463 NM_001069 TUBB2 gttcttggagtcgaacatctgctgggtgag 464 NM_001079 ZAP70 tcaggtggtcaggcgtagatcaccagaata 465 NM_001092 ABR attgatgtaaaccacgtgagaggaaaatgt 466 NM_001130 AES gctgtatcaagggtgggcttagctgtgcct 467 NM_001150 ANPEP tccctaaagaccctaaatctgaggaatcaa 468 NM_001165 BIRC3 cattgtactaataccgggaacatgaagcca 469 NM_001175 ARHGDIB cccaactgatatgttcatagaatgacagtt 470 NM_001178 ARNTL gcactccagctaacaaaagattgacaataa 471 NM_001207 BTF3 cattctttgcagctaattaagccgaagaag 472 NM_001211 BUB1B agatgcactaccattgctgttctacttttt 473 NM_001219 CALU aatgcgaacaggtacctatctgtttctaaa 474 NM_001226 CASP6 atcgttagggtgaagcattatggtctaatg 475 NM_001228 CASP8 gtgaactatgaagtaagcaacaaggatgac 476 NM_001229 CASP9 agcaaaccggggcctactagagtctgaaca 477 NM_001237 CCNA2 gttgtggccaagtacaaattatggtatcta 478 NM_001239 CCNH tctgcataatcaaaggggtagcacaaataa 479 NM_001255 CDC20 aagcgaagagcaacgcacgagagaaacgac 480 NM_001256 CDC27 ctccatacagtgtactcttattcttggcaa 481 NM_001265 CDX2 gtctgtgtaacatccaagccagagttttta 482 NM_001266 CES1 aagactggggtcttttgcgaaagggattgc 483 NM_001273 CHD4 ataccacctccaccgctgagcagtgacctt 484 NM_001274 CHEK1 gcaaactgcaaatagtagttcctgaagtgt 485 NM_001280 CIRBP cctgtgaaagtcggattcgaataaagggcc 486 NM_001295 CCR1 aacaatgatggacttcaattgtactcactg 487 NM_001312 CRIP2 tgtgctgtcaataaacggtttgaggattgc 488 NM_001313 CRMP1 tggcacttgtaactcaccgtgctgtcttct 489 NM_001337 CX3CR1 cttcaagatcatgtaccccaatttacttgc 490 NM_001344 DAD1 agatacgaacaacgcaaccgcacgcagcca 491 NM_001345 DGKA ccctggatgcagacgccctgtacaatcaag 492 NM_001398 ECH1 gggcgatgacagttgtttctatgccttctg 493 NM_001404 EEF1G ccaccaattcatgcgctatcaaatgtatta 494 NM_001428 ENO1 agagtcatgtgagcctcgtgtcatctccgg 495 NM_001436 FBL cagcatactaaccagacagcgacacgcaga 496 NM_001441 FAAH acataggccaaggcccaactaacagtcaag 497 NM_001456 ELNA agggagccatttggtggcgctgcttgtctt 498 NM_001459 FLT3LG aagccctggatcactcgccagaacttctcc 499 NM_001462 FPRL1 ctgaaaaggaattgagaagtaattcctctg 500 NM_001489 NR6A1 gacattaggtcagccactagatgtatttgt 501 NM_001513 GSTZ1 cccgcgctgaaatttggcgtgaattaaact 502 NM_001515 GTF2H2 gttatggatgtcagggggaattgaaagacc 503 NM_001540 HSPB1 cccttgccgttacttacgaaacacccaaaa 504 NM_001560 IL13RA1 ttttggtagtcttcaaccagggattgtttc 505 NM_001607 ACAA1 ccgctgccgtctttgaataccctgggaact 506 NM_001630 ANXA8 ccaaggacactgtgttataagaggcgtggg 507 NM_001640 APEH tctggctacgcacacacttgggcagctgaa 508 NM_001654 ARAF ccatgtggattttgggggtcccttttgtgt 509 NM_001664 RHOA ctcataccacttgtttctgccgtgctcatg 510 NM_001700 AZU1 gctgtaataaagaagccgatctctcctctg 511 NM_001712 CEACAM1 acacggactgtgcatactttccctcatcca 512 NM_001715 BLK tagtatttgggcatggcttacacctgtcat 513 NM_001716 BLR1 aagctgggtaatcgatgggggagtctgaag 514 NM_001728 BSG aatgctgtctggttgcgccatttttgtgct 515 NM_001734 C1S tggacaaatcgccagagatgtggtaagtga 516 NM_001743 CALM2 gttgttgttgaagtgtggagttgtaactct 517 NM_001747 CAPG aagacggcagaacgagtaagaacagacagg 518 NM_001752 CAT cccactttctatagcagattgtgtaacaat 519 NM_001753 CAV1 atgcatgtcctgtaaaggttacaagcctgc 520 NM_001759 CCND2 agctgccttttaagaggtcttatctgttca 521 NM_001767 CD2 agttacagggtgatgcttagagagggcttg 522 NM_001772 CD33 cactaaagatcacgtaccatatgattccat 523 NM_001774 CD37 ttcatgacgctctcgatattcctgtgcaga 524 NM_001776 ENTPD1 tctagaaaactccttaccatttgtcttagg 525 NM_001783 CD79A ctctttcctcgcgccgtgccgtttttacct 526 NM_001786 CDC2 cttatcttggctttcgagtctgagtttaaa 527 NM_001793 CDH3 agatgaagggtgaggacaatcgtgtatatg 528 NM_001794 CDH4 cataactgccaggttccgacttctgtccac 529 NM_001795 CDH5 ctgcaagggattgtagataacactgacttg 530 NM_001798 CDK2 ggtcatagtgggtggatttgttgccatgtg 531 NM_001830 CLCN4 tgttggtcttcaggaggggaagtttgctgt 532 NM_001838 CCR7 ttctgctttcgattcgttaagagagcaaca 533 NM_001839 CNN3 ccaatgtatcaatgtagagttgctctgttt 534 NM_001897 CSPG4 aataggataatatattcagggtgcagggtg 535 NM_001901 CTGF ccaaaagttacatgtttgcacctttctagt 536 NM_001905 CTPS cagactcgatgtgtactctaacttaagaaa 537 NM_001908 CTSB gccacaaattcataaccacttatccttcca 538 NM_001916 CYC1 acaacaagacaacgcacgaacaacgagcgg 539 NM_001923 DDB1 atgggtagcctgggtgtaaaacctggagat 540 NM_001928 DF ggagtcgatataaggcgtacggcagaatgc 541 NM_001939 DRP2 tgattcttctgaccctagaaatgttccctt 542 NM_001941 DSC3 ccaagactttactagtgccgataaactttc 543 NM_001952 E2F6 ctcattgggtaagtcatttaccactctgtg 544 NM_001964 EGR1 tattgcccatgggatatgtggtgtatatcc 545 NM_001993 F3 ggtacttaaagcttctatggttgacattgt 546 NM_001999 FBN2 accaaacctcatatgtgaaatggccaaagc 547 NM_002015 FOXO1A cagattccacgttcttgttccgatactctg 548 NM_002017 FLI1 tggaaatgcgtgtaacagtactgcaataat 549 NM_002023 FMOD catgagtggtggctaacctgaccaataaag 550 NM_002033 FUT4 ccttggtatttagtttggtgaatacttgca 551 NM_002046 GAPD cccacaaacacgaaacgggaatccattttt 552 NM_002049 GATA1 gaaggatggtattcagactcgaaaccgcaa 553 NM_002064 GLRX ccctacaccaagagtgtatctgtgaaagag 554 NM_002065 GLUL gtaaacaaactgtgtaactgcccaaagcag 555 NM_002067 GNA11 cctcttcacccatcaacgctgtgctttgcc 556 NM_002068 GNA15 accagaattctaggtgcgagtctcagctgt 557 NM_002076 GNS ccttcaaaaggaccctgttcactgctgcac 558 NM_002086 GRB2 atagcatttggtaggtagtgattaactgtg 559 NM_002090 CXCL3 cttacttctctcctgtcagttggtgctccc 560 NM_002094 GSPT1 agacagcaggttaatacctagatctcattt 561 NM_002102 GYPE ccatgcaaaactgtagatcaataaaacctc 562 NM_002107 H3F3A attttgggtagacgtaatcttcaccctttc 563 NM_002108 HAL ggaatctttggggattaaccaacctccttt 564 NM_002110 HCK aatccacaatctgacattctcaggaagccc 565 NM_002118 HLA-DMB gtgtgccatagaggacagcaactggtgatt 566 NM_002121 HLA-DPB1 caaatctgcctgataggacccatattccca 567 NM_002128 HMGB1 tgtgtacccgaggggtaatgattaaatgat 568 NM_002129 HMGB2 gcacagcaaacttgtaggaattagtatcaa 569 NM_002135 NR4A1 tttttaacacatagcgccgtgctgtaaata 570 NM_002141 HOXA4 gtgcatttagacttatgtggaactgtacaa 571 NM_002145 HOXB2 acacagaaaaattccgtttggtagactcct 572 NM_002162 ICAM3 tccagttctgtgcggcatgagaaaggggct 573 NM_002166 ID2 tgtgtttattgaatggtgattgcctgcttt 574 NM_002167 ID3 aggcacaagaacacgagacaacgcagacac 575 NM_002186 LL9R cacataagtgcatcttgcggggcagtgagt 576 NM_002193 INHBB gaaactggactcgtacgactctttttatat 577 NM_002198 IRF1 tacactaacatttcccccgagctcttggcc 578 NM_002199 IRF2 tatgcttgaatgccacgcggtacaaaggaa 579 NM_002222 ITPR1 gcctagttttgtacatggatctcattttac 580 NM_002224 ITPR3 tgagctgcgcttgcgtggctgtttcatgac 581 NM_002228 JUN gcttaccaaaggatagtgcgatgtttcagg 582 NM_002229 JUNB gaaacacgcacttagtctctaaagagttta 583 NM_002230 JUP tgcagggtcgttgtcaggttatgtgagaaa 584 NM_002248 KCNN1 accaaccgcgttgatggacacccactgtgt 585 NM_002276 KRT19 aacggagagaaggacacgacgacagagcag 586 NM_002295 LAMR1 acataagatgcctccgtgagaggctggtgg 587 NM_002312 LIG4 gatccatgcgatactatgtgtgcattattt 588 NM_002341 LTB agtcaagggagtagccggggtagtggctta 589 NM_002349 LY75 gaaaagcacggctgtatataatggtgatgt 590 NM_002351 SH2D1A agcatttaatatggatgccgtgggagtaca 591 NM_002353 TACSTD2 ggcgttgtggctctaagattaaacgacttt 592 NM_002356 MARCKS cctgcttaaggtgttctaattttctgtgag 593 NM_002379 MATN1 tcactcatcgcagttctccccacggctact 594 NM_002388 MCM3 tctttgcagtagcaccagttaaggtgaata 595 NM_002390 ADAM11 gatcgtctccaattcgaaaacaaccgtcct 596 NM_002392 MDM2 cctactttggtagtggaatagtgaatactt 597 NM_002393 MDM4 ccactaacttctgtaatgtaagattgagtc 598 NM_002398 MEIS1 gcgcatggctgaaatcctaggcgagaagaa 599 NM_002412 MGMT ccgctgtattaaaggaagtggcagtgtcct 600 NM_002414 CD99 ccctgccgccctaacaataggagatagaag 601 NM_002415 MIF tcaccccctttggttcattctcccgaatgt 602 NM_002417 MKI67 ctggttactgtatcccagtgaccagccaca 603 NM_002419 MAP3K11 ttgaccggaggagaaacgtcttcgaggtcg 604 NM_002421 MMP1 ggcaagggataactcttctaacacaaaata 605 NM_002422 MMP3 agagaaggggaagcactcgtgtgcaacaga 606 NM_002436 MPP1 tctataatgccaaaatgacacatctgtgca 607 NM_002441 MSH5 tgtcctcattctcccctatatgacatgcaa 608 NM_002444 MSN atgtcctatattggctaaattgaaacctgg 609 NM_002447 MST1R cccttgaaccaataaaggaacaaatgacta 610 NM_002460 IRF4 gtaagttatgttttacatgccccgtttttg 611 NM_002462 MX1 ttcagccctcagaatcgctccaccttgcag 612 NM_002466 MYBL2 gctcctggtgctaacaacaaagttccactt 613 NM_002475 MLC1SA tgcactatcccacacacgtactcaccacgc 614 NM_002483 CEACAM6 tttccttgttccaatttgacaaaacccact 615 NM_002512 NME2 acagcgcacgacagcacgaagcggaaaaac 616 NM_002514 NOV ttaatgccaccacacgtgttccgcttctct 617 NM_002527 NTF3 aaaacttgttttgtgatccggctctcagga 618 NM_002530 NTRK3 gttgaacatcaaggagatctacaaaatcct 619 NM_002572 PAFAH1B2 atgcccggctcttaggaattttgtctgttt 620 NM_002576 PAK1 tcatgctctgaggtactactgcctctgcag 621 NM_002585 PBX1 tcagcctggttttcgtcatcttccctgccc 622 NM_002592 PCNA aagtgaacacacacgaccaacagcagcgcg 623 NM_002600 PDE4B tcttctgataacacttgttaggcctcttac 624 NM_002608 PDGFB cacgtgaacttgtgcgtgtctctggcagtg 625 NM_002609 PDGFRB ggactcacgttaactcacatttatacagca 626 NM_002616 PER1 gctgtaccctctgccgatggcatttgtgtt 627 NM_002619 PF4 cattcttcagcgtggctatcagttgggcag 628 NM_002621 PFC tcaaccccgtgaggtgagtattaatattac 629 NM_002648 PIM1 ggcattgctgactgtgtatataggataatt 630 NM_002658 PLAU ccttttagcctagttcatccaatcctcact 631 NM_002659 PLAUR cactctcctctggacctaaacctgaaatcc 632 NM_002687 PNN tatctgttggccattactatacatgtgcaa 633 NM_002704 PPBP gaacccattgcaaccaagtcgaagtgatag 634 NM_002729 HHEX aataaagccgtccgtgggacgactgacctc 635 NM_002730 PRKACA tgcgaaggacgagacttcctcttgaacagt 636 NM_002744 PRKCZ gttcatctttcgtcctgtgtctgactttct 637 NM_002753 MAPK10 tatatggggggagtgagctctctcagaccc 638 NM_002758 MAP2K6 atagatcccctgagaggtatctgagaagaa 639 NM_002791 PSMA6 aagacgagacgcaaacgagccaagcagagg 640 NM_002800 PSMB9 tagcatataagccaggcatgtctcccgagg 641 NM_002814 PSMD10 cacattttaagttggatggtgtgctctaaa 642 NM_002827 PTPN1 atgtgacaacaattgctaaagcaaaccttg 643 NM_002831 PTPN6 tctccctgaccctgtatatagcccagccag 644 NM_002835 PTPN12 cagtaagtgccttggaacaatattgaattc 645 NM_002844 PTPRK tttctagattgccagctcatgacatggtgc 646 NM_002856 PVRL2 actggacttctcccgtctctagggctgcat 647 NM_002868 RAB5B acagaatgcgactgctgatttaccgatgta 648 NM_002870 RAB13 aggctagctcggcactacactagggaattt 649 NM_002880 RAF1 tttcttaggggacacgtcctcctttcacag 650 NM_002887 RARS tgtccaaaggatgtaatccttcataggttt 651 NM_002893 RBBP7 acaagtagcagggtattgcctttgattcaa 652 NM_002901 RCN1 gcttataccatggaatgaggacaaggtgat 653 NM_002908 REL gcaattgagtgactcctttccatatgaatt 654 NM_002913 RFC1 aggaactggtagtcttgtttgggtgatgag 655 NM_002934 RNASE2 tgacctgtcctagtaacaaaactcgcaaaa 656 NM_002935 RNASE3 acgggattctccacggtatcctgtggttcc 657 NM_002936 RNASEHI cattagttgtctgtcaaggaaggtgagtgg 658 NM_002953 RPS6KA1 cagctccttttccgttctgttctgctggga 659 NM_002960 S100A3 gcgcagaagtgtgaccgactgaatcataaa 660 NM_002961 S100A4 ctcgcgttctgatgacacgtctactaaaac 661 NM_002971 SATB1 agaaatgttctgactaggagtggttattga 662 NM_002972 SBF1 cagagtctatataaagagagaactaacgcc 663 NM_002975 CLEC11A atgttggcgtacacgttgcaggctgcgtga 664 NM_002983 CCL3 cctcttctatggactggttgttgccaaaca 665 NM_002984 CCL4 gttatgacgaaccatccgcccgccaagctt 666 NM_002985 CCL5 attaccactcaaacgcgaaacacaatcaaa 667 NM_003002 SDHD aacgatagagacagaacgcatgcgcgcagg 668 NM_003005 SELP tcaagctagaaggccacatgtcaccgtgga 669 NM_003006 SELPLG gtactgaagagtgacggacttctgaggctg 670 NM_003009 SEPW1 agcgagacaaacgcgagcataggacaccca 671 NM_003025 SH3GL1 acgtctccagcacacctgaagaactggagg 672 NM_003038 SLC1A4 gctgttctctttctaacatgttgtggtaaa 673 NM_003039 SLC2A5 tattaccggcctcgtcggtgtggtctgtct 674 NM_003058 SLC22A2 tcatgaggtccttccatatttagattgggt 675 NM_003072 SMARCA4 gtgcgtcaccgtccactcctcctactgtat 676 NM_003073 SMARCB1 ttgtcaccaccatcgcatacagcatccggg 677 NM_003100 SNX2 aagtggactgtggcatgacattctgcaata 678 NM_003113 SP100 catagtgctaaaagcagaactgccattcca 679 NM_003118 SPARC ccaaaatcaagagtgagatgtagaaagttg 680 NM_003120 SPI1 gaaggggcggttctcctcgaccttagatga 681 NM_003121 SPIB gttcaaagagagaattatatgctggcgcgg 682 NM_003123 SPN cttcttgacgcttttcataatgtgcaaagt 683 NM_003127 SPTAN1 tgccctcattccgacttcagaaaatcgaag 684 NM_003128 SPTBN1 tctctgtgcctaatgttcctcaatgtggtt 685 NM_003133 SRP9 gcatggtaagttcccttagctatatgaatt 686 NM_003159 CDKL5 gacataccatgagaatgcggcactgacggg 687 NM_003189 TAL1 gtgaggatgtatcgggaagatttctaaata 688 NM_003200 TCF3 gacctgtcctgtatataacagcactgtagc 689 NM_003222 TFAP2C cccaaataattgttgtgtgtatgatacgtg 690 NM_003225 TFF1 cgccactacgcctctactacacgaacacaa 691 NM_003234 TFRC gaatgaaatatcagactagtgacaagctcc 692 NM_003262 TLOC1 tcaaaggccaatgatacttcgcataattca 693 NM_003288 TPD52L2 cccatgcccactctttaggcacaaatgcag 694 NM_003302 TRIP6 tcctttgattgatcactctccctgacatcc 695 NM_003311 PHLDA2 aaatgaaattgcggccattgatctctaacc 696 NM_003315 DNAJC7 aaagggaaccaatgccgaagaccgagggca 697 NM_003318 TTK attttactcttggaatagtgggtggatagc 698 NM_003352 SUMO1 gagaggaaacgagtagggacaaacacgagg 699 NM_003361 UMOD aatgggacttgtgacggtgtacctgaggcc 700 NM_003383 VLDLR aggacaaaacgggttactaagatgaaattg 701 NM_003390 WEE1 ttcttggttgagattggttggttgagactc 702 NM_003395 WNT9A tccgagtctccgtgcgtgcaatgatttctc 703 NM_003403 YY1 gtgctcagttgtagaatgtattgtaccttt 704 NM_003415 ZNF268 tgtatcggaagcatataccttggagggacc 705 NM_003425 ZNF45 tcagtttctggctagcaactagaagttttg 706 NM_003427 ZNF76 ggtggcacatggatgaatgagtatttaata 707 NM_003453 ZNF198 ccttacaaggttatgtagagagataccatc 708 NM_003467 CXCR4 cctacagtgtacagtcttgtattaagttgt 709 NM_003480 MFAP5 tgaccctcctactccacattgcaacatttc 710 NM_003549 HYAL3 atagactgccccgacagtctacaagcctca 711 NM_003582 DYRK3 gtggacagagatatgcccagagatgcatat 712 NM_003627 SLC43A1 tacccctgaggtcccatgtgccatgagtgt 713 NM_003636 KCNAB2 agactcagaccgcgacacagccaccgtatt 714 NM_003645 SLC27A2 gaaatttgcatacccgtaaagggagacttt 715 NM_003692 TMEFF1 cagattggaataaagcctattctaccagtt 716 NM_003701 TNFSF11 caccaggtgcctttcaaatttagaaactaa 717 NM_003707 RUVBL1 tgaaagaacccttccttacctggtgtgttt 718 NM_003739 AKR1C3 acttctcccgccgtattggttgcggacctt 719 NM_003746 DNCL1 aaggagcgaccgaagacaagcgaacgagac 720 NM_003753 EIF3S7 cttagtggaatgtgtgtctaacttgctctc 721 NM_003801 GPAA1 atgttccgcaagctcaaccacctcctggag 722 NM_003805 CRADD tcctcccctgtaatacttagcaggccagtt 723 NM_003821 RIPK2 gtccccatttttaacctcagccttccctac 724 NM_003824 FADD aggcagcgggatctcgtatctttaaaaagc 725 NM_003842 TNFRSF10B ctgccctgtcaaaggtccctatttgaaatg 726 NM_003852 TIF1 gtaggttagatgctattaagaaggcactta 727 NM_003874 CD84 ttggtccttctatcactaaaactcatctca 728 NM_003877 SOCS2 tttctgaatgaccggaagttcttctgatct 729 NM_003879 CFLAR acatggtaaacgctgtccctagtaaaaatg 730 NM_003884 PCAF gctttgtaccggatctgctgaagcatctgt 731 NM_003900 SQSTM1 tggatgggactccatagctccttcccagga 732 NM_003902 FUBP1 agggccaataataagaagtggacaatacag 733 NM_003914 CCNA1 atggaagcacttccagaacttcacctccat 734 NM_003954 MAP3K14 agactccgtgggagaagctcattcccacat 735 NM_003955 SOCS3 gtattctgtgtcaggtattgggctggacag 736 NM_003974 DOK2 cctgcacctttcagatttcttggtggcatt 737 NM_003998 NFKB1 attaaaggtatcacggtcgccacctggcat 738 NM_004039 ANXA2 acacagacggaagggacaaggagcggaaca 739 NM_004047 ATP6V0B ttgctgcgtgttgatttggaggcactgcag 740 NM_004064 CDKN1B cttaaaaggttgcatactgagccaagtata 741 NM_004067 CHN2 tattttacgtggagcatcattgtgtgactg 742 NM_004077 CS taaacccctgggtaactgtcaagtcatgat 743 NM_004083 DDIT3 acatacgcagggggaaggcttggagtagac 744 NM_004088 DNTT gttgtcactggtggctcattcagggaagct 745 NM_004093 EFNB2 ttgctgcatatttgtgccgtaattatgtac 746 NM_004099 STOM cttgggagggacgcatagaaggagctctag 747 NM_004104 FASN taactgtcagtgtacacgtctggaccccgt 748 NM_004111 FEN1 gaaactcgaacttgctatgtaatttgtgtc 749 NM_004119 FLT3 tggagcattgatctgcatccaaggccttct 750 NM_004177 STX3A cttacagtttggaatacaacatgtgaaggt 751 NM_004208 PDCD8 gagtgtgaatgatcaagtcctttgtgaata 752 NM_004221 NK4 aaggacagaaccacgacacgacacagagaa 753 NM_004235 KLF4 tttttatgcagacagtctgttatgcactgt 754 NM_004310 RHOH gaaatctagccagtgtgtagacaatgttga 755 NM_004313 ARRB2 taaaacagagatattaggagctccatcact 756 NM_004320 ATP2A1 tccccaccccgatagtgacacatcttcagg 757 NM_004324 BAX acgcaaggactagcggagacaagacagagg 758 NM_004335 BST2 tgtttgtaaaaagggccagacaaaggggca 759 NM_004336 BUB1 gctcttagaatgtaagcgttcacgaaaata 760 NM_004343 CALR ctggttcggatttggggtggattttggttt 761 NM_004355 CD74 acagggagaagggataaccctacacccaga 762 NM_004374 COX6C ggctattcagagtggtcagggagcttagag 763 NM_004380 CREBBP ctttaagatcccctgtaagaatgtttaagg 764 NM_004385 CSPG2 aaggactccaatgtcgaactcttctttgct 765 NM_004413 DPEP1 caagtatccagacctgatcgctgagctgct 766 NM_004425 ECM1 ctgaacactcattacactaaacacctcttg 767 NM_004430 EGR3 gacaatcagccggcctataaatctccttat 768 NM_004448 ERBB2 ttcttgtatcccttttacagtcaaagtcca 769 NM_004449 ERG tcatggatagctgcaatttctcactttaca 770 NM_004454 ETV5 catcctgccaagctgcgttatattctgtac 771 NM_004475 FLOT2 gttggggacagaaaagtgtgtagaccttct 772 NM_004494 HDGF gtcaccagatctgatttgtaacccactgag 773 NM_004501 HNRPU gtttctgacaataactgggaaggttttttc 774 NM_004508 IDI1 tcaacccccaactgaggaccactgtcctac 775 NM_004513 IL16 catgaaactccaccttgcggggataaagag 776 NM_004526 MCM2 cactctcttatttgtgcattcggtttggtt 777 NM_004530 MMP2 agcatgtccctaccgagtctcttctccact 778 NM_004557 NOTCH4 ctgctatcgctatttaagaaccctaaatct 779 NM_004583 RAB5C tgtgcctgtctacctgcgcgtttgctgtac 780 NM_004615 TM4SF2 cccacagtatattggttattggtcctgaag 781 NM_004624 VIPR1 tgcaacaggcttgtgcaacaataaatgttg 782 NM_004633 IL1R2 gaaaagcagatggtctgactgtgctatggc 783 NM_004642 CDK2AP1 gatctcagttctgcgtttattgtaagttga 784 NM_004688 NMI acaacaattgagacacaagcggtccctctc 785 NM_004689 MTA1 ggcttgcttctatgggctttgcaccaccct 786 NM_004706 ARHGEF1 catcactgagactgccggatccctgaaagt 787 NM_004725 BUB3 ccctagtaagcccagttgctgtatctgaac 788 NM_004815 PARG1 tagttctatgtgatgtaaaggtctagggag 789 NM_004827 ABCG2 gaataggtaggttagtagcccttcagtctt 790 NM_004867 ITM2A gagtttaggttgtatgaattctacaaccct 791 NM_004924 ACTN4 atgaagacatagccgattctctgcccgggc 792 NM_004936 CDKN2B cctgttaagttcgtatctaaacctaagaca 793 NM_004938 DAPK1 ggtttcataacttcctgtacttgaagtcta 794 NM_004941 DHX8 accagcaggtggtctatatccatccttcca 795 NM_004972 JAK2 gctcattaagaagtgcagcaggttaagaat 796 NM_004994 MMP9 ctacgtgacctatgacatcctgcagtgccc 797 NM_004997 MYBPH accaggcctacagtcaaactccagagatgc 798 NM_005012 ROR1 catggtggagcgtgacgattgtcccagcta 799 NM_005080 XBP1 ctagtgtagcttctgaaaggtgctttctcc 800 NM_005084 PLA2G7 catgttacagaactcttcaggaatagagaa 801 NM_005085 NUP214 tccctcccactattaaacagtctgtttccg 802 NM_005098 MSC aagtgatcctgcgatagggaacgcgccctt 803 NM_005104 BRD2 ctccccatttggtcccctggactgtctttg 804 NM_005123 NR1H4 cacaactgtaaatattgggctagatagaac 805 NM_005157 ABL1 ttctaagtggcgtgtgcatagcgtcctgcc 806 NM_005161 AGTRL1 ctcaaagcatccagtgaacactggaagagg 807 NM_005178 BCL3 gtaacgggcacggatcacgatgtaaattat 808 NM_005187 CBFA2T3 catgatggtaataaacgagatgtttgccaa 809 MM_005192 CDKN3 aacttctctccgccccggttttctttcccc 810 NM_005197 CHES1 ttcagcaaacaagtgctagcttcactgacc 811 NM_005215 DCC gcataccaattacccataaacagcacacct 812 NM_005225 E2F1 aggcctgggtgatttatttattgggaaagt 813 NM_005230 ELK3 gggcaatatgaaagcatatatcacgttttg 814 NM_005239 ETS2 ggggttcagcctaacagttatggaaactac 815 NM_005245 FAT ttattggaaagtgtaacggggaccttctgc 816 NM_005246 FER gtcctccagcagagtaacattattgttctc 817 NM_005248 FGR acaccacctagggcaacctacttgttttac 818 NM_005252 FOS attgttgaggtggtctgaatgttctgacat 819 NM_005263 GFI1 ttgaccctccatgtgtaccatagagggggg 820 NM_005317 GZMM acagggagggaccaataaatcataatgaag 821 NM_005318 H1F0 gggctagtacttagtttcacacccgggagc 822 NM_005334 HCFC1 taccatagtgcgatgtcgttttgtgctatt 823 NM_005335 HCLS1 acccgggaaagtacgtctagattgtgtggt 824 NM_005339 HIP2 gaaggttggggtatttgtcttgagaattaa 825 NM_005340 HINT1 aggcaatgattaagttaggcaatttccagt 826 NM_005356 LCK caggactttatctaatacctctgtgtgctc 827 NM_005375 MYB atgacggtgtacttactgccttgtagcaaa 828 NM_005385 NKTR cctctgctgcagcgttcaacttgtgtgttt 829 NM_005424 TIE1 aacatgccctgttcagctactcccactccc 830 NM_005427 TP73 tttttaacaggattggggtgtccaaactgc 831 NM_005439 MLF2 gatcccatcgtgaccgacggtgtttgtgta 832 NM_005494 DNAJB6 aaaactgttggtgaggtagtgtttcagtta 833 NM_005504 BCAT1 gatcatccgcaggctatgttaaaaggattt 834 NM_005521 TLX1 atgggcatctatgggagagtgtcaaccaga 835 NM_005529 HSPG2 gtcctagaagggaccctcctgtggtctttg 836 NM_005533 IFI35 ccgaatcttctgtgttcgttcttctttgct 837 NM_005556 KRT7 gatgaattccactggtggcagtagcagtgg 838 NM_005563 STMN1 ttatttaaagggaccttattttctgcccct 839 NM_005566 LDHA ttttggactcctatcccgttatgtctgggc 840 NM_005572 LMNA agcctgcgtacggctctcatcaactccact 841 NM_005583 LYL1 ttaacccctttggtactctcctgcatctcc 842 NM_005589 ALDH6A1 gcttatctgaaagtagtgcttaaacctgat 843 NM_005608 PTPRCAP tcacgcgtacctctacttatcaactaacgt 844 NM_005621 S100A12 ggagtaagagttaataaacacactcacgaa 845 NM_005651 TDO2 gtgacaagactaagcattaagatgagaaag 846 NM_005654 NR2F1 aggatcagatctgtgagcacgttggcgagg 847 NM_005671 D8S2298E actttcgaatcacaccataccttgattgag 848 NM_005687 FARSLB aagctgggtctcatgtttgagacaagttcc 849 NM_005730 CTDSP2 tcccccttcaagatgccatttggagggtag 850 NM_005731 ARPC2 tcctcgcgcccgtgcaggtgacaaataaca 851 NM_005738 ARL4A ccctttgtagcctaagtacgtaaacaaatt 852 NM_005761 PLXNC1 gtttgcacataggttccactttgggcactg 853 NM_005767 P2RY5 tcactgggacagaactttcaagttccttca 854 NM_005781 TNK2 agcggagaaagggtgccagaccattctctg 855 NM_005794 DHRS2 ggctgatccaattaacatgtggggttcttg 856 NM_005808 CTDSPL caatcaaaaggtttgcaatgatttccttcc 857 NM_005809 PRDX2 atatatatcgcgacatcaccggcccgaatc 858 NM_005826 HNRPR cccaatgctttctgatagtaggagataatt 859 NM_005835 SLC17A2 cagcaccgatcagaactgtaaagctataat 860 NM_005845 ABCC4 gacagtcatataaacgtcctgtttctgttt 861 NM_005870 SAP18 ggatgtgctattgtatgattacgaatagtc 862 NM_005895 GOLGA3 aatgttgtacgtgaagattctaggagggga 863 NM_005900 SMAD1 gctctcgtacattgagtacttttattccaa 864 NM_005902 SMAD3 gtctaccagttgacccgaatgtgcaccatc 865 NM_005907 MAN1A1 caaccccatggattaggctgaaacatatga 866 NM_005911 MAT2A cttaattgccacctctaacagcaccaaatc 867 NM_005923 MAP3K5 gcttgttctaaagctatccattgtgtcata 868 NM_005933 MLL ggccctaggggttccactagtgtctgcttt 869 NM_005936 MLLT4 cccatacacaagtggatttggccatctttg 870 NM_005944 CD200 tgttctaaagatattgttccagctagtgga 871 NM_005954 MT3 tgacgcgtttccgcgtattgtcccctataa 872 NM_005956 MTHFD1 ctgggagttaggaagtataagtaagccaag 873 NM_005957 MTHFR gcaactagccaaggctagttcctttcaatt 874 NM_005965 MYLK aaaggataccacagtgcatgctgtttgttc 875 NM_006005 WFS1 ggtgaatgtgtgaaggtcttgcctgaatcc 876 NM_006017 PROM1 actggtcggacaaaatttaacgttgatgta 877 NM_006038 SPATA2 gtcacagactggaatacgaaatactacagc 878 NM_006060 ZNFN1A1 ggcatttggaaacgggaataaacaaaattg 879 NM_006079 CITED2 ggccaaactgttctggatcaggaaagtcat 880 NM_006082 K-ALPHA-1 gaaggagaggaatactaattatccattcct 881 NM_006084 ISGF3G tcatctgtaagggactaggaaattccaaat 882 NM_006098 GNB2L1 tcggcacacgctagaagtttatggcagagc 883 NM_006101 KNTC2 ggagcagattgctaaagttgatagagaata 884 NM_006113 VAV3 ctgcagatttgtgtagagttctaataccaa 885 NM_006120 HLA-DMA gtgtcccttccccttatgattttactttcc 886 NM_006142 SFN cagtgcaagaccgagattgagggaaagcat 887 NM_006152 LRMP ttatctccccaactaaaatacaatggggaa 888 NM_006184 NUCB1 ttccatgttccggttccatccaaatacact 889 NM_006185 NUMA1 ttaagggccggggatggatcttttctaaat 890 NM_006187 OAS3 cagcatattcataactagagccatatcaca 891 NM_006190 ORC2L cagcttacagtcatcacataccccctgaaa 892 NM_006191 PA2G4 aggtttgtgccccactacagaacagggcta 893 NM_006196 PCBP1 atgatccaactgtgtaatttctggtcagtg 894 NM_006209 ENPP2 acatttagtcctgtactgtatggaaacact 895 NM_006216 SERPINE2 ctcctgtcttgctagacaaggttgctgttg 896 NM_006230 POLD2 tattagtttcctgtaggcgctgtaacaaag 897 NM_006231 POLE agcactacggcatgtcgtacctcctggaga 898 NM_006235 POU2AF1 agaatccatgtagaagtcatggacttttct 899 NM_006255 PRKCH ctcatgtcagtgaccagatttgtggcttat 900 NM_006263 PSME1 gacgctcccttgtcgttcagtatgtcggag 901 NM_006268 DPF2 cctaactcactgtcgctttggagttgaggt 902 NM_006273 CCL7 gtagttgaagtattaatcccaactggctga 903 NM_006286 TFDP2 attcctatgaccaaattgcttgcctacagt 904 NM_006299 ZNF193 tattacccctatatgcatcaaagctgcaac 905 NM_006301 MAP3K12 tactgtaacccctgtgaaaaaccttgaaat 906 NM_006302 GCS1 ttggataccagtaattcaaaccttcctcat 907 NM_006325 RAN tattgcgaattgcgtcgaacctcccctccc 908 NM_006329 FBLN5 ttttacccaattggattggaatgcagaggt 909 NM_006343 MERTK ttttgtttgctgacgactcctcagaaggct 910 NM_006354 TADA3L caggcatctgtgactgaccgattgatttga 911 NM_006355 TRIM38 tccagtctgctaggaccaattaccttgaaa 912 NM_006362 NXF1 tgtacttaaccccaggacctccttactttt 913 NM_006427 SIVA taggactttgacgtttgaatggtggggggt 914 NM_006472 TXNIP ttggtcagtcactctcagccatagcacttt 915 NM_006495 EVI2B gatcaagatcttaatgaatccctgccacct 916 NM_006509 RELB gtggggggtaggttggttgttcagagtctt 917 NM_006522 WNT6 atccgcgcgttggtgcaactgcacaacaac 918 NM_006534 NCOA3 aaccacatgaaatgacttatgggggatggt 919 NM_006559 KHDRBS1 ctacatgtgtaagtctgcctaaataggtag 920 NM_006565 CTCF ttaggacgccaacatgagacctgtaataaa 921 NM_006579 EBP gggttgctctagtcagggatgttacagttg 922 NM_006591 POLD3 aattatgctggggtctcgactaaaactgaa 923 NM_006602 TCFL5 gaatgtattctgatcggatcgtttatggtt 924 NM_006676 USP20 atgtctgtgctgtctagtttgtgttcaaaa 925 NM_006739 MCM5 gtgcttttggcatccgttaataataaagcc 926 NM_006747 SIPA1 tggagaccctaagggaactccaaaatctga 927 NM_006748 SLA ggatgctgggattcttgcctgtatgaatgc 928 NM_006759 UGP2 gattgtgtgaactattcatctggctcttgg 929 NM_006762 LAPTM5 ttcagtcaaagcaggcaacccccttgtggg 930 NM_006769 LMO4 cagagacatttgctctagtatggtgtattt 931 NM_006803 AP3M2 aataactgtcctgtcacatgtgcagcaggc 932 NM_006820 IFI44L gaagcggtgggctaagataggtcctactgc 933 NM_006825 CKAP4 ctctgagctgtattgttctttaatggctgt 934 NM_006845 KIF2C ctaaaccttctacgcctttgggccgagcac 935 NM_006857 RY1 cctcccatgacttgccattataattaaaac 936 NM_006875 PIM2 accggacaccaccagacactaggatgggat 937 NM_006904 PRKDC tgttagggatagtactaagcatttcagttc 938 NM_006910 RBBP6 ctgaattcattacaaccctgttatgtcact 939 NM_006931 SLC2A3 gcagtaaggcagggtcccatttctcactga 940 NM_006932 SMTN cccatgatcatcatgtcgtccacctccacc 941 NM_006937 SUMO2 gcacttatcataagtaaatactccctaacc 942 NM_006938 SNRPD1 cagtgcctcctttattaaggggttctttga 943 NM_006963 ZNF22 tgccaagtgtcagactctaatgagccctca 944 NM_006981 NR4A3 tgccttctgtgggcggaaatcaggaagcca 945 NM_006994 BTN3A3 gagttgacatccctattgactctttcccag 946 NM_007022 CYB561D2 tacctataccgcaagaggatccaaccatga 947 NM_007063 TBC1D8 cactgtttcaatgctggtaattgaaaccat 948 NM_007065 CDC37 ctatttggcaaacagcaatgatcttccaat 949 NM_007079 PTP4A3 caggtgctccggacacccgaaggcaataaa 950 NM_007111 TFDP1 gaatgcaactttctaaacagccccaagcaa 951 NM_007117 TRH atcacagtagcgctcatggctcgtaggttt 952 NM_012092 ICOS tagtttacaagtgagacccgatatgtcatt 953 NM_012120 CD2AP tttttgtttgtgaccactaagcttctgtct 954 NM_012207 HNRPH3 cagcatctggtctactagactttcttacag 955 NM_012223 MYO1B aaggtgattggtacagggtgcctattttag 956 NM_012267 HSPBP1 gaagaccagaagcacgacagacgagacgag 957 NM_012317 LDOC1 acgttcgaggcgggcgccctcattatttgt 958 NM_012323 MAFF tacagcaagcgagttatcgtcttctgtatt 959 NM_012334 MYO10 tgtccctttgtgtacaaccatgcaaaactg 960 NM_012384 GMEB2 gcaagtatctgcctggtactttgatttaaa 961 NM_012417 PITPNC1 ttaaacatgtaacagttgcagattggctca 962 NM_012423 RPL13A ggcatctgttggactttccacctggtcata 963 NM_013282 UHRF1 agcactgcaaggacgacgtgaacagactct 964 NM_013314 BLNK ggtgaggttgagttatcatgctactaatat 965 NM_013416 NCF4 cttcacctcgatgacgaaaacctaaggagg 966 NM_014005 PCDHA6 attgaatgttctggttcaaggctccacctc 967 NM_014207 CD5 ctctttcatctatagtttggccaccataca 968 NM_014232 VAMP2 gtgttctagaccccccatattatcccagtg 969 NM_014244 ADAMTS2 aatattgtccccccctaccttaagaagata 970 NM_014298 QPRT aatggggcacatttggcactagcttgagcc 971 NM_014345 ZNF318 cacaaacccatatgtatcctttcctcaacc 972 NM_014365 HSPB8 ggtattgtgtatatgggcgggacgtgtgtg 973 NM_014575 SCHIP1 ctgtctctcccaacgtgactatgaattccc 974 NM_014595 NT5C cttacctactcccgtctagaaaatgctgaa 975 NM_014614 PSME4 ttatcttgttacaaaaactgagatgtgggg 976 NM_014624 S100A6 gatataggcatcgcacctctatcatcgtca 977 NM_014667 VGLL4 tgtcagtgaacaagggcgtcactctgggag 978 NM_014707 HDAC9 taatgaaggcactgcttatttgtagtcacc 979 NM_014724 ZNF305 acaagaccgtgtaggtgtcccttcagagag 980 NM_014734 KIAA0247 caggatgtcactcaatcagtttgggtttgc 981 NM_014735 PHF16 catgcctttcaattctgagtgggaggaaaa 982 NM_014780 CUL7 taccttccggtagccctagacttggggtca 983 NM_014792 KIAA0125 gacattgagaattggtacctacaacagtct 984 NM_014824 FCHSD2 gatcacttcagtgacaatacccattaatga 985 NM_014890 DOC1 cacacctcttcctcgacaatcacaaattac 986 NM_014899 RHOBTB3 agtataatattgggaccccataccgttagc 987 NM_014914 CENTG2 tgtttagatttccacgttacacaaacacac 988 NM_015050 KIAA0082 gtgtcttgcagaatcttggatcattaaaga 989 NM_015069 ZNF423 ccagttcaccggacagtgattaaaactatg 990 NM_015099 CAMTA2 gtttatacgaattgccattaaacatcgctg 991 NM_015147 KIAA0582 ttgttgtaaatcccaatctttactgccatg 992 NM_015149 RGL1 taatgcttttagctgctcgcatgcttgtct 993 NM_015158 ANKRD15 ggattcctttttaccgtgtcacatttactt 994 NM_015166 MLC1 tgggggcagaccagagagctcaagtttcag 995 NM_015196 KIAA0922 tatggactaccacagcgaataggaatgcaa 996 NM_015210 KIAA0802 ccaacaggagagatctagttttctcaaggt 997 NM_015261 KIAA0056 ctttattccatttgaaagtgtcaagcccat 998 NM_015335 THRAP2 gctggtacagtacactaaaagactttgata 999 NM_015436 RCHY1 tacgaattttttggtgcatagcatctcagc 1000 NM_015458 MTMR9 gtgtgtaatatttgcgtatggtgttcctct 1001 NM_015474 SAMHD1 ctaagcataagtgaaagacacctcccctca 1002 NM_015528 RNF167 ccttacccacacctatccttttgaggggct 1003 NM_015568 PPP1R16B tgaggtaacttccacgtagccccttgccac 1004 NM_015570 AUTS2 atcggcggagccttcttgtgtaatgtaaac 1005 NM_015636 EIF2B4 gtacctgttgttctacgagtcaagagcagt 1006 NM_015670 SENP3 tgagagaatacttgttgatttctgatgtgc 1007 NM_015710 GLTSCR2 agatgccggagactcgcccttcaataaaaa 1008 NM_015833 ADARB1 ttacaactgcatgagcttcctctcgcacaa 1009 NM_015855 WIT-1 gtctgaggttacaattagaactcctgaccc 1010 NM_015869 PPARG taaactacaattgtttggcaccctctcttc 1011 NM_015965 GRIM19 cgcgctgttgccactgttacaggcagaaac 1012 NM_016041 DERL2 acaccatcctccattcgacccattgacttc 1013 NM_016091 EIF3S6IP aactcagttaacaagttaaggaccgaagtg 1014 NM_016184 CLECSF6 ggtctgtacattgactgattcactttttca 1015 NM_016195 MPHOSPH1 ggatgtaataggtcaggtatttggtttact 1016 NM_016221 DCTN4 atgagctaagtgtcatgcatatttgtgaag 1017 NM_016308 UMP-CMPK gaaagaccccaatttaagccttgcttattt 1018 NM_016343 CENPF ctggtgatggattaacatatagcctttgtt 1019 NM_016570 PTX1 gtatcccccccatattgtgatgatgcaatc 1020 NM_016734 PAX5 agaacactcggaggggcgggaatcagaaga 1021 NM_017437 CPSF2 actatgtgtggaacaacccagtaatatcag 1022 NM_017448 LDHC tggagaacagaagatagcaggctgtgtatt 1023 NM_017617 NOTCH1 atgccagtgagggacgtcagacttggctca 1024 NM_017771 PXK cgttcacaacattctcttaagttctaacag 1025 NM_017787 C10orf26 cagacagaagcttgactgggtcttcaatga 1026 NM_017794 KIAA1797 ttagtacccgggccagttgagactgaaaca 1027 NM_018136 ASPM ttcaagacttaagccagattgggttttgag 1028 NM_018209 ARFGAP1 agggagtcccttttgatgggaagtgcagtc 1029 NM_018248 FLJ10858 atgcttttagtctcttgtaactggggagaa 1030 NM_018462 C3orf10 caatgacataacagagcacgcatcagaaga 1031 NM_018664 SNFT acatccaacaggcgccaaactcacagagcc 1032 NM_018951 HOXA10 gcgtggaaaaagacgatgtttatgttctta 1033 NM_019028 ZDHHC13 ttatgtcgatgccctgtagtttgaaagtga 1034 NM_019071 ING3 gaaggggaaagggcgttaaagtgatacatt 1035 NM_019102 HOXA5 gctgtactaacgaccaccaagacgccacca 1036 NM_019111 HLA-DRA ggcagaatataaacgacgcaccttcttccc 1037 NM_019841 TRPV5 agtaagctgtgaggctattctggctcccca 1038 NM_019846 CCL28 ctttcaggtcctgcatactgatgaaactac 1039 NM_019857 CTPS2 cccatgtcagtttctattgcattgagagcc 1040 NM_020310 MNT cgagacatgaatactatccatgtaataagc 1041 NM_020368 SAS10 cctaactataattattgggccagatacttg 1042 NM_020371 AVEN ccttgtttctagcctccttccttgcagtgt 1043 NM_020631 KIAA0720 aagcactgggaagtaatggggtgtggggtg 1044 NM_020657 ZNF304 aatagttgacagatctaactttcctagtgg 1045 NM_020841 OSBPL8 cagatagttataggccactgttttgtaatg 1046 NM_020843 ZNF291 gcttaataatgggcgataatgtcaagtgat 1047 NM_020892 DTX2 gcgaagacctgacgagagactgtaaaggaa 1048 NM_020944 GBA2 ccctgactgcgtgaaatgttcagggaggtc 1049 NM_020956 PRX aactagcactaaccctaagagggccgggag 1050 NM_020998 MST1 cttcttgtcagacataaagccatgtttcct 1051 NM_021019 MYL6 acagagcacaacaaaggacgagcagcgcca 1052 NM_021025 TLX3 gccgggcgcctgtattatactttgtacttt 1053 NM_021038 MBNL1 ctaccattaaggtgaaatcatggatcagat 1054 NM_021071 DO tgatcctatagctattgcatctctctcctt 1055 NM_021103 TMSB10 acttgtacgcctcccgtgagaccactctgt 1056 NM_021111 RECK agtgctgatgtagcatgcttgttgcaattg 1057 NM_021114 SPINK2 ttatcgcgcgtctatatggccccgatcacc 1058 NM_021603 FXYD2 cctctcttcgcttcacttggactgaccctg 1059 NM_021643 TRIB2 tagtgtgtggcatgtatgtgcagactcttg 1060 NM_021814 ELOVL5 cacatacaattacgtaccatatacagtgct 1061 NM_021906 USP9X agtgcaaagcaatgaaacgtccaatggtta 1062 NM_021949 ATP2B3 gaatggcttggtcaactgtgttcagttcat 1063 NM_021960 MCL1 tcaaatgtagtgtgtttccctaactttctg 1064 NM_022067 C14orf133 ctgacatgcctagactcctaataaaggtat 1065 NM_022127 SLC28A3 tgcacatgaatcatgagtcccttctccact 1066 NM_022161 BIRC7 tgcttggcgtgggggatggcttaactgtac 1067 NM_022334 ITGB1BP1 atctgttcataccgcatgacaccgtccact 1068 NM_022366 TFB2M ctggtttgcctttcagtttgttgaaatgta 1069 NM_022436 ABCG5 ggagttacctgatcacatcgagagagtgct 1070 NM_022438 MAL tgatggatcttaggttgcctgaaggcacgt 1071 NM_022469 GREM2 gctccttctggggttatcgtatgtacaaag 1072 NM_022549 FEZ1 taacaacagctcacagccaaatagagcaat 1073 NM_022716 PRRX1 tagtcatctatccgttcttcacttagcagg 1074 NM_024006 VKORC1 ggatttcagttccccgcgtcctcattaaat 1075 NM_024099 MGC2477 gggaagtaccttcattgggttgttctgaaa 1076 NM_024319 C1orf35 agccatgggcctatgagcggtctaactgtg 1077 NM_024408 NOTCH2 gcatattcctgactaaacgtagtaaggaaa 1078 NM_024424 WT1 aaggcaaagacacgtaaatctctgccaaca 1079 NM_024713 C15orf29 tgagttatttaagaggccagttttcaggac 1080 NM_024728 C7orf10 gctctggtattaatgaatctagtgcctttt 1081 NM_025263 PRR3 aatgggtcaggagttgtattggcaagaggg 1082 NM_030660 ATXN3 ttagtttcagtgttccctatccctcattct 1083 NM_030674 SLC38A1 gggtgatttaagtgagtcacaagtcacaaa 1084 NM_030915 LBH acttctatctgttcttttttgaggctcagg 1085 NM_030926 ITM2C gaggagggctgtaacgccttcagtcagtct 1086 NM_030935 THG-1 agacagcgacgatgatagtggctccggaag 1087 NM_031243 HNRPA2B1 tggtctttgtaagagtgtagaagcattcct 1088 NM_031423 CDCA1 gaaaagttgaagcgaatggaagtatcagaa 1089 NM_031966 CCNB1 gtaaaagtctaccaccgaatccctagtccc 1090 NM_032121 DKFZp564K142 tgagggctagacgtgtgctctgaagaatgg 1091 NM_033238 PML attccgtagggtcttgttcccacgaccgga 1092 NM_033512 TSPYL5 ggtaatttgacaccctgttaataacgcaat 1093 NM_033554 HLA-DPA1 atagcacatttccaactaataacaccccct 1094 NM_033642 FGF13 atacccaaatacgcaccgaataaactcttt 1095 NM_057168 WNT16 ggacatcgaagagaatttaacttagcagtt 1096 NM_058195 CDKN2A gttgtatttcgtcttatgtctcgagttcct 1097 NM_080284 ABCA6 tggccttatttttccaatcccagagcccac 1098 NM_080700 TREX2 atcgagcccatgtacttgccgcctgatgac 1099 NM_130439 MXI1 ggtggtgtagattgtatgagtaagaagtat 1100 NM_133259 LRPPRC caagctctgccctaggcttgttactttata 1101 NM_133378 TTN caacactttgttcgctcattttacgctgtc 1102 NM_138714 NFAT5 tgttctctgggggaatttcatttgcatcta 1103 NM_144578 C14orf32 agtttgagatactaggttttatcacctgct 1104 NM_144628 TBC1D20 aacttgtccatgtgccaagagggtggcgca 1105 NM_145698 ACBD5 gataaccatttctatcctgttccaaagtct 1106 NM_145867 LTC4S aggaacagcgggaagtactcgctgcagttc 1107 NM_147180 PPP3R2 ccttgaactgagagcctgtatctggattta 1108 NM_152739 HOXA9 accgccattgggctactgtagatttgtatc 1109 NM_152788 EB-1 tccttcactttagtggtctaatcaacagat 1110 NM_152827 SNX3 actacaccattggtttccaatactgcacac 1111 NM_152890 COL24A1 cacagcaaaccacacttaacctatctataa 1112 NM_156038 CSF3R ccaggcgatctgcatactttaaggaccaga 1113 NM_172020 POM121 gatttctagaactccctctttgcatagtgc 1114 NM_173156 C1orf16 catcctcactgtggagtaatgagggggagg 1115 NM_173216 SIAT1 gctgcctgtgtctatggggttctgtcttct 1116 NM_173609 C15orf21 tcaaccctcactaaactttgccggttcaga 1117 NM_173852 KRTCAP2 tccaccgagtctgtgtcaccacctgcttca 1118 NM_175739 SERPINA9 tgggatgttgctgggttaccatatttccat 1119 NM_175744 RHOC aggggggcatgaataaaggctacaggctcc 1120 NM_178586 PPP2R5C ctttttagtgtggctttagtatggcttcct 1121 NM_181311 TAZ agaaggcaggtgagcaaccagttggctagg 1122 NM_181336 LEMD2 gccccgtggtgaggccatgttctcataatc 1123 NM_181339 IL24 atatcacttccatgacataagtgctattgc 1124 NM_181430 FOXK2 agatcccaggtctctccgtggtatgtttgt 1125 NM_181493 ITPA gtgattcacttattcgccctccctactttg 1126 NM_181702 GEM atatagaattgggaactgatacatgtgtcc 1127 NM_182729 TXNRD1 gtggagtggaatgttctatccccacaagaa 1128 NM_182810 ATF4 tcaggagcgtcaatgtgcttgtacatagag 1129 NM_183395 CIAS1 gctttttgtagctggttgaaaattcaggaa 1130 NM_198232 RNASE1 ctcaaggcgggttaaacggttactcaaaag 1131 NM_198400 NEDD4 tgcgggacagtcagtaggatcattttcata 1132 NM_199335 FYB ataatacaggaacaggtatagatgtagcct 1133 NM_199423 WWP2 taactgaagtgtctgtacggaatgcccttt 1134 NM_201592 GPM6A gaaatgtagaacagagtgcttgcaaaatgt 1135 NM_201632 TCF7 gttttcaccatagcctacgttaacccattt 1136 NM_201998 SF1 aacactgcgctaaagcggggatgttccatt 1137 NM_212474 FN1 ctaatggagatagctttacactttctgctt 1138 R14777 CYFIP2 cataggatccaactggacaacgtgtgggat 1139 R56397 PIK3C3 tattacatggtacctgagttctgcttcctt 1140 R59027 GRP58 attttagtcccagccttgcagcttacacac 1141 R72151 GNL3 cattgtgagtggaagtagttatctggaata 1142 R79128 MAP3K1 ttgagtttgtttgcagttccctcagcttgc 1143 R86893 C6orf110 ctcccacgtctatgttcacatttgtggtcc 1144 T07281 NRIP1 aaagaatgtgctttgattcgaagggtctta 1145 T28925 ITGAL cgtgggacatctagtaggtgcttgacataa 1146 U60115 FHL1 catctaacgtttcagtgtatccttacagaa 1147 U79271 AXT3 atatgccacaacgcaccacgaccttcccag 1148 W04885 MYL4 ggcggtggggtctagattccacatttatgt 1149 X66087 MYBL1 atacttgcatggaaactgactacacataca 1150 AK024272 gaacattccaacagcagaatacatgttctt 1151 AK025231 IGLC2 gatgggatttcacctaattttaatgtggct 1152 AL080190 tctccttcgtgtgttcacctctcccccaga 1153 BU618233 agaggcaactttgcggtccatcacgcaatc

TABLE 21 50mer polynucleotide probes, according to one embodiment GenBank Accession No. SEQ ID NO: for Target gene Symbol 50mer 1154 AA594161 MYH11 atgaagttgagagcgtcacagggatgcttaacgaggccgaggggaaggcc 1155 AA766908 MME ttttagtccaaataacaagtaccaaagttttatcaagtttgggtctgtgc 1156 AB014540 SWAP70 ttaggagtcaaatagtctctgcatggtggggaggatcatgatggaatatg 1157 AF196185 PARD3 cacgtgcggcggtgtctaagtggtgttaccagtgtacgcgcagtgacctt 1158 AI597616 MRPL33 actgagggcggggatactgattcagaaaccctgtagcgtgtaataaaaga 1159 AI634809 ARID5B aagcttagctggtcatatttctacttgcttccttttagcttctgccttgc 1160 AI672553 AKAP12 gctggactgcattcacacatggcatgaaataagtcaggttctttacaaat 1161 AI809213 RGS13 atgagatttctatcgtacagggcaagcctacattgtggacatattctaga 1162 AK022231 STAT1 ataatatgcacacagtgctttccgtggcactgcatacaatctgaggcctc 1163 AK022293 CTSD gcacccctagctcttgggatgtttgtatccaactccgggcaatgtggggc 1164 AK055652 C3orf6 tgggttctgatgggaatatatacactcatctggactaggccaatggaagc 1165 AL080130 FLJ14001 atttagctgcataaaacgttcggctcatttatctgacatcttagtcacat 1166 AL833316 MIR tttttgggccttaggcgtttcgttcatcctgctaaggggatgaagcaaac 1167 AW291384 STS-1 caaatgcatcaattataccagggatgtatagtaagtcagggaactaatat 1168 BG993697 SMYD3 cctttccatgctacacaagcaagaaatgcctataaagacagacttgagtg 1169 BI769730 HLA-DRB1 gaaatatgcacaatcgcggtgtacgaggagcatacgccacacttatgatt 1170 BQ632574 RASA1 tcccgtgatttagcagcattgcatgagatttgcgtggctcattcagatga 1171 BX504817 SFRS7 catcaagtttattcggtagtttgaccgctagtatgttggaagttatttgg 1172 H53164 IRF8 cagcaccaatcccgcattcagaacctcccagtgaaagggcagccttcatt 1173 H57732 TGFBR2 aatgtgtccaaaaggttggatggcaaggtttgggtgctactgccttggca 1174 L29376 3.8-1 tatatgtacagtttcacatatgtataaaaacagtagtttgggggcctctt 1175 M80899 AHNAK aaaggccctaaatttaagatgccagacatgcacttcaaggcccccaagat 1176 NM_000038 APC aagcagcctagcacagactaagcattgagcataataggcccacataattt 1177 NM_000043 FAS ttcgtgagctcgtctctgatctcgcgcaagagtgacacacaggtgttcaa 1178 NM_000061 BTK atttccagtccggtggtccccaccggaagtcctgatgtatagcaagttca 1179 NM_000075 CDK4 cagaggtagaacgcatatcgacgtagacttatcgttacaactaattagaa 1180 NM_000109 DMD tcagcctatgctgctccgagtggttggcagtcaaacttcggactccatgg 1181 NM_000189 HK2 atacagtggatctcaatcttcggggtgtgatgaatagcgaatcatctcaa 1182 NM_000237 LPL tcgtgcctataaatagtaggaccaatgttgtgattaacatcatcaggctt 1183 NM_000269 NME1 gtggaaatgcgtgtcacggccccgtcttaccgctagttccctgcatagca 1184 NM_000271 NPC1 ggaatgcacagttgacttgggaagcagtattactagatctggaggcaacc 1185 NM_000295 SERPINA1 tgctccctccgtctctaccaggaatggccttgtcctatggaaggcactgc 1186 NM_000313 PROS1 taatatatcggatacaggccctaagtctatgttccgatcaacaatctcat 1187 NM_000397 CYBB cccttggagccacaaatgtttagaactcttcaacttcggtaatgaggaag 1188 NM_000405 GM2A gtataactgtgagtcttggagccatagtaatgtttctcatgccccccaaa 1189 NM_000424 KRT5 ttatccttttctggagagtagtctagaccaagccaattgcagaaccacat 1190 NM_000483 APOC2 catacctgcccgctgtagatgagaaactcagggacttgtacagcaaaagc 1191 NM_000576 IL1B aagaatctgtacctgtcctgcgtgttgaaagatgataagcccactctaca 1192 NM_000579 CCR5 ccttttgctcttaagttgtggagagtgcaacagtagcataggaccctacc 1193 NM_000584 IL8 ctattaaaacagccaaaactccacagtcaatattagtaatttcttgctgg 1194 NM_000585 IL15 ttatttcacttgagtccggagatgcaagtattcatgatacagtagaaaat 1195 NM_000600 IL6 gagcccagctatgaactccttctccacaagcgccttcggtccagttgcct 1196 NM_000626 CD79B tagtgacgctgcggacaggggaagtgaagtggtctgtaggtgagcaccca 1197 NM_000627 LTBP1 gctgctgtacatcaggcgcgggatggggagataactgcgaaatcttcccc 1198 NM_000633 BCL2 atggcaaatgaccagcagattcaaatctatggtggtttgacctttagaga 1199 NM_000655 SELL gtagcctcgccgtctgtgaattggaccatcctatttaactggcttcagcc 1200 NM_000713 BLVRB aatgacctcagtcccacgacagtgatgtccgagggcgcccggaacattgt 1201 NM_000785 CYP27B1 cttgcccctaggaaggtgaatctgccctagcctggtttacggtttcttat 1202 NM_000788 DCK cttaagtataaaccttatgaactacagtggagctacactcattgaaatgt 1203 NM_000853 GSTT1 aatctcaggatggacgcacctccgatgaattcctctgacattctgccagg 1204 NM_000877 IL1R1 gaaatagccaccgtctacagatggcttagttaagtcatccacagcccaag 1205 NM_000917 P4HA1 tcagcgtcacataaaaagagcatgtaggatgggacatattgggatgtatt 1206 NM_000927 ABCB1 atacatggttttccgatccatgctcagacaggatgtgagttggtttgatg 1207 NM_001067 TOP2A gttatattgataaccatgctcagcaatgagctattagattcattttggga 1208 NM_001068 TOP2B tgtccttaagcacaacagtcataccagcacaacgcaatgcttatgtcct 1209 NM_001110 ADAM10 ggaagacatttcaacctacgaatgaagagggacacttcccttttcagtga 1210 NM_001154 ANXA5 tatagtcccagatgtatctcccttaatcatggaataaagagaggtggcaa 1211 NM_001166 BLRC2 agagtataatggaagatagcacgatcttgtcagattggacaaacagcaac 1212 NM_001196 BID tgctttcctcaaacaggatactgcctgctgtaagaccatcctctatggtt 1213 NM_001230 CASP10 ttattgcctctttcacattgaaacccaggagtggataacactggcttcag 1214 NM_001238 CCNE1 tatggtatacttgctgcttcggccttgtatcatttctcgtcatctgaatt 1215 NM_001242 TNFRSF7 acctgaattcccaccgcagagagtgttgtggccgtgaggacttttctgtc 1216 NM_001254 CDC6 ttttagactcgttgagtttcttgggcactcccaagggcgttggggtcata 1217 NM_001350 DAXX gggataacatttggaggaaggtgggaagcagatgactgaggaagggatgg 1218 NM_001425 EMP3 cagctttgcaccagcgtggcggtgtttactggcggccttgatctatgcca 1219 NM_001552 IGFBP4 ggcttgactggatggaaggagacttaggaacctaccagttggccatgatg 1220 NM_001558 IL10RA actgacttgtctaattcgtagggatgtgaggttctgctgaggaaatgggt 1221 NM_001618 PARP1 ggtgtagacgttcctcttgggaccgggatttcatctggtgtgatagacac 1222 NM_001621 AHR catgaggtatctaaggatttagaccagaggtctagattaatactctattt 1223 NM_001647 APOD tctgcccctagtgtgtgttgcgtgtccgctccacggcgtacatgttgctt 1224 NM_001663 ARF6 tggttagctggttaggaccagtaactggattgcgaccactatgataatat 1225 NM_001706 BCL6 tgtttgtctcatcccattctgcgtcatgcttgtgttataactactccgga 1226 NM_001760 CCND3 cctgttgacacaggtctttcctaaggctgcaaggtttaggctggtggccc 1227 NM_001762 CCT6A agatgatggaaggtgtggtgactaagggccacggttattgggtgaaattt 1228 NM_001770 CD19 acacctgactctgaaatctgaagacctcgagcagatgatgccaacctctg 1229 NM_001771 CD22 ttggaagtgaggcattgcacggggagacgtacgtatcagcggccccttga 1230 NM_001779 CD58 gttcctttcatcacaacaaacgttatggagattatgcgataccaggcact 1231 NM_001781 CD69 gatgtggcaaatctctattaggaaatattctgtaatcttcagacctagaa 1232 NM_001782 CD72 agttgactgatgatacacaacgcactaggacttatgctcaaagctcaaaa 1233 NM_001826 CKS1B gatcatgtcgcacaaacaaatttactattcggacaaatacgacgacgagg 1234 NM_001827 CKS2 cagctaaacactcctgcggtcgtatggtcgacaacaatcacacataaaat 1235 NM_001831 CLU acttaaagcttagcttatgtccaaggtaagtattttagcatggctgtcaa 1236 NM_001852 COL9A2 ctgaaggaatagggcggctttccttccagcgagcatcattcggctgttac 1237 NM_001853 COL9A3 accctcatcgggctgtcgcctgacagcatacctcaaaaggccctagctaa 1238 NM_001877 CR2 cttcttaccttcttgattgtcattaccttatacgtgatatcaaaacacag 1239 NM_001888 CRYM tttatgtttgtagttggaaagcaaagctaggtagccatttcttctgttct 1240 NM_001894 CSNK1E gccagcccgaattcccgttctcctgtgtctactaacaaggacatgggggt 1241 NM_001951 E2F5 gacattccactttcctaggttataggaaagatctgtttatgtagtttgtt 1242 NM_001967 EIF4A2 aatatccttgctgcgtaaactgcacgggtctttaagctccagacgttttc 1243 NM_002002 FCER2 tgtgtgcaacacgtgccctgaaaagtggatcaatttccaacggaagtgct 1244 NM_002051 GATA3 tgaataagccattctgactcatatcccctatttaacagggtctctagtgc 1245 NM_002095 GTF2E2 acagaaaaagcgacgctttaagactcataacgaacacttggctggagtgc 1246 NM_002101 GYPC taactgagcatacccagtgggccaacaagcacgctctaaatacaaaacca 1247 NM_002105 H2AFX gcctacccaccaatccttaacgcgcctcaccggaccttaacattccaccc 1248 NM_002120 HLA-DOB cattgccaagggcattgtccagaaactcccctgagaccttactccttcca 1249 NM_002122 HLA-DQA1 gccacccggctacctaattcctcagtaacctccatctaaaatctccaagg 1250 NM_002155 HSPA6 tatcttatatatctgtattcgcatggtaacatatcttcggccttcctgag 1251 NM_002189 IL15RA cggtacatttgtaactctggtttcaagcgtaaagccggcacgtccagcct 1252 NM_002211 ITGB1 gttatactgtggctatgcaacagctctcacctacgcgagtcttactttga 1253 NM_002217 ITIH3 tgactacattgtccccaacctgttttgagtagacacaccagctcctgttg 1254 NM_002250 KCNN4 taactcaccagcctctgctcttatctttgtaataaatgttaaagccagaa 1255 NM_002305 LGALS1 tggcggcggatggagacttcaagattaagtgcgtggcctttgagtgaagc 1256 NM_002350 LYN tgatttcatgtgcggggatcatctgccgtgcctggatcctgaaatagagg 1257 NM_002358 MAD2L1 ccagaacatgttacaccactcctacgatggcttgcccgattcgatgcccc 1258 NM_002426 MMP12 aaatagttaccttcaaaggccaagagaattctatttgaagcatgctctgt 1259 NM_002467 MYC tcctcaagaggtgccacgtctccacacatcagcacaactacgcagcgcct 1260 NM_002526 NT5E gcagcaaaataatagcctcggttctatgcatatatggattagctataaaa 1261 NM_002567 PBP accccccacgatccaagagaaaaaccgatagcacgtaacccgctgctcag 1262 NM_002646 PIK3C2B gctcattttattatgacctatatgctcctgatttaaagagatctgtgtac 1263 NM_002661 PLCG2 agaagatatgttcagcgatcccaactttcttgctcatgccacttacccca 1264 NM_002692 POLE2 ttccacccactgagccctctagtactactagggcatactatggaaatatt 1265 NM_002738 PRKCB1 aaattgtgagtaagctttgcagttactgtgaactattgtctcttggagga 1266 NM_002752 MAPK9 acgaagctctgcgtcacccatacatcactgtttggtatgaccccgccgaa 1267 NM_002832 PTPN7 ctcaaataataccctgggtatgcaggacccactataccttgcatttgctg 1268 NM_002838 PTPRC cttatgattataaccgtgttgaactctctgagataaacggagatgcaggg 1269 NM_002891 RASGRF1 cccggggacatgtgctagatgatactgtacatattcgtttggtttcactg 1270 NM_002892 ARID4A agaggcagaagtcaaaacggggacgacctcctttaaaatcaaccctctca 1271 NM_002943 RORA acctaataaacacaacttttactaattatctatactactacaa 1272 NM_002966 S100A10 acggatcgctcccatgtttggtccacttaccacccactttgtgtttcctt 1273 NM_002967 SAFB cttggccatcaaataagtaggcatagagtgtgactcgccctctcttggtc 1274 NM_003037 SLAMF1 aggccctccacgttatctaggagatcgctacaagttttatctggagaatc 1275 NM_003088 FSCN1 actttgacatcgagtggcgtgaccggcgcatcacactgagggcgtccaat 1276 NM_003177 SYK ctgcaagaaatgtgttgctagttacccaacattacgccaagatcagtgat 1277 NM_003217 TEGT acttccttcctgttaaacccctgttaactctccataaatttggtgattct 1278 NM_003226 TFF3 tgtatccgaaacacggtgacaccgctggtgccggctaaacccccattgtg 1279 NM_003243 TGFBR3 caggtgagaacatccataatttggggccctgagttttacccagactcaag 1280 NM_003254 TIMP1 atacatcttggtcatcttgatctcataacgctggtataaggtggtctggt 1281 NM_003290 TPM4 ccttatgagaagaggccagaacttggttatcctcttccaatgtgaggaca 1282 NM_003299 TRA1 ggatctaaaaagagcgattacattaagctctatgtgcgccgtgtattcat 1283 NM_003332 TYROBP tgagagaccagaccgctccccaatactctcctaaaataaacatgaagcac 1284 NM_003362 UNG gttcactgatgcagttgtgtcctggctaaatcagaactcgaatggccttg 1285 NM_003451 ZNF177 gactgatgtactgtggcagacagaactagttgctgtctcaatatccattc 1286 NM_003648 DGKD tcttgccaagcgcagtcgcagtggtaaattccgcctcgtgaccaagttta 1287 NM_003656 CAMK1 caaagagtttggcatcattctcgtcatagaagggagggtaaccgcagagc 1288 NM_003810 TNFSF10 aaaagagagaagaggcaccactaaaagatcgcagtttgcctggtgcagtg 1289 NM_003875 GMPS tctggctaggcttatacctcgcatgtgtcacaacgttaacagagttgttt 1290 NM_003959 HIP1R acatccgggagattggagacctgtggggacatttgcatgaccgctacgga 1291 NM_004049 BCL2A1 aatctggctggatgacttttctagaagttacaggaaagatctgtgaaatg 1292 NM_004073 PLK3 ataagcctgagccttagctcccagctagggggcgttatttatggaccact 1293 NM_004091 E2F2 acccaaatactcacaagggtcttatcagacgcccgtcttaaagtccagca 1294 NM_004117 FKBP5 ttcagtccttacgggtaaacagattgagcatggctctctattccctcagc 1295 NM_004126 GNG11 atcacccaagagccataatacacctattataagcgaccagcataataaag 1296 NM_004184 WARS ggccctcacagatgtctaggcaggcctcatttcatcacgcagcatgtgca 1297 NM_004271 LY86 tcagcccgcgcgtggaaccgagacaagtaaacaagacgccagatctctga 1298 NM_004289 NFE2L3 cactgaccatgaatctagttcccatcatgacttagaaggtgctgtaggtg 1299 NM_004322 BAD cctagcacaaaataagggcataagaaatactagttacatcacaaggtcag 1300 NM_004354 CCNG2 tcacacatgcaaattgtcagcttattgagacaacccacttagattcatat 1301 NM_004356 CD81 cgtcgccttcaactgtaatcacaacatcctgactccgtcatttaataaag 1302 NM_004358 CDC25B gagattactctaaggccttcctcctacagacagtagacggaaagcaccaa 1303 NM_004422 DVL2 aggaagctgggagatttgggccatgtagctgcctttgttactctatttat 1304 NM_004445 EPHB6 agcccaggactcggggtgaagtattacatcgacccctccacctacgagga 1305 NM_004510 SP110 tgatggttttagcaatacctaaatccgtgatatcatcagaggttgcaaaa 1306 NM_004529 MLLT3 gaaatcaacgttaccgccatttgatgatattgtggatcccaatgattcag 1307 NM_004556 NFKBIE cagacccttgtccttgctgtggaaatgatgagggatggagggacaagagg 1308 NM_004577 PSPH tgtgatcaggcaacaagtcaaggataacgccaaatggtatatcactgatt 1309 NM_004619 TRAF5 attctgggccggtaccaggttggtattactcatgaacgatatctgctttt 1310 NM_004635 MAPKAPK3 ttgatcctctacaactggtgttgctcccgttatgcggacagaagacagcc 1311 NM_004737 LARGE gttccaacaagcaataccgcatctgtctcaaaaccctcaaggaagagttt 1312 NM_004844 SH3BP5 gctatcattctagggctggatttccctaactccagttattctgctgctgc 1313 NM_004851 NAPSA gcgcagcgggtggtcgcggaggtcctgctacccagtaaaaatccactatt 1314 NM_004951 EBI2 gaggatgctgaaacggcaagtcagtgtatcgatttctagtgctgtgaagt 1315 NM_005013 NUCB2 gcggcaacaagtgatctggaacactatgacaagactcgtcatgaagaatt 1316 NM_005077 TLE1 atgggttgtaggattgaggaacggaatctgccgactcacatgacagccca 1317 NM_005127 CLECSF2 tttgtacctgtctggttaattctgcttacgtgtcaggctacacataaaag 1318 NM_005211 CSF1R gctgactcatcctaactaacagtcacgccgtgggatgtctctgtccacat 1319 NM_005213 CSTA aacactttgggtacatgctgctaaaagcccgtcagctcgtcatccttgtt 1320 NM_005214 CTLA4 caccttatatttacgtatgagacgtttatagccgaaatgatcttttcaag 1321 NM_005271 GLUD1 aacagtagtgtccccatgaagtgctagataatatatgtgtaagagtcagc 1322 NM_005292 GPR18 gtcattagtgtcatgctataccgtaattaccttcgaagcatgcgcagaaa 1323 NM_005347 HSPA5 aaggctctcactaccgtggaccacctagtctgtaactctttctgaggagc 1324 NM_005348 HSPCA agttgacaattctgcatgtactagtcctctagaaataggttaaactgaag 1325 NM_005415 SLC20A1 ctccaagaagcgaattcgaatggacagttacaccagttactgcaatgctg 1326 NM_005449 TOSO tagttgacaggtaagctgtaggcatgtagagcaattgtcccaatgccact 1327 NM_005461 MAFB tttaactttagcatgttgttgatcatggatcatactccccttgtttcttt 1328 NM_005531 IFI16 ctgctttgaattggcaccgaaaagtgggaataccggggagttgagatctg 1329 NM_005582 LY64 ccaaacgggaatatccaatctcgagtttattccagtgcacaatctggaaa 1330 NM_005601 NKG7 cgtccactcccccgctatccaacgtcacatctaagcactatgacatgcac 1331 NM_005606 LGMN ctggcactcccccacgtacgagtatgcgttgagacatttgtacgtgctgg 1332 NM_005610 RBBP4 gcatctctagcccactttatatcctgccaccagtacttcttgtaatccca 1333 NM_005623 CCL8 tgttgtggggtcctcccatggatcatcaaggtgaaacactttggtattct 1334 NM_005638 SYBL1 gcatgttttagggatcaattacctaactgttccttggtctatttatgtat 1335 NM_005652 TERF2 acaggagcatggttcctaataatagcccctgatagtctgctctttctttc 1336 NM_005658 TRAF1 atccctactcaccgagtgttgagcccaaggggggatttgtagaacaagcc 1337 NM_005856 RAMP3 tctcatcccgctgatcgttatacccgtcgttctgactgtcgccatggctg 1338 NM_005935 MLLT2 ttgttttgggtcccacttaggattaacggatgtaaggtattttcctgtgc 1339 NM_005950 MT1G acattatcaactagatactacacataccagcaccactactcacactacag 1340 NM_005951 MT1H gtaaaatccaggattttatattcctacaactccgactcatttgctacatt 1341 NM_006006 ZBTB16 gcctgagaagcatctgggcatctactccgtgttgcccaaccacaaggctg 1342 NM_006014 DXS9879E acaacaccagcgcccaatatacgcgaatgaggcgccctatacccgcctct 1343 NM_006115 PRAME tctaagtggggtcatgctgaccgatgtaagtcccgagcccctccaagctc 1344 NM_006162 NFATC1 tgcttattacgtatgattactcacagcgatctattgttccatataaccaa 1345 NM_006164 NFE2L2 ggccagtaaacacctgttcctgagtgatacatctttaaggagccggtaga 1346 NM_006195 PBX3 ttctgtagcttagagtgctcacttactacctctgaacaatactcacgctg 1347 NM_006218 PIK3CA actgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaa 1348 NM_006254 PRKCD tccgtgtggacacgccacattatccccgctggatcaccaaggagtccaag 1349 NM_006257 PRKCQ gacaagtaatcactaacccgttttattctattcctatctgtggatgtgta 1350 NM_006274 CCL19 acctcagccaagatgaagcgccgcagcagttaacctatgaccgtgcagag 1351 NM_006317 BASP1 ggccccggcagctaattccgaccaaaccgtaaccgtgaaagagtgacaag 1352 NM_006332 IFI30 atgcaccgcttgtcaatgtgaccctctactatgaagcactgtgcggtggc 1353 NM_006475 POSTN aagactgcttcagggagacacacccgtgaggaagttgcaagccaacaaaa 1354 NM_006498 LGALS2 ctgtgctcagggtctcaactcgtggtcaagcttatatcctagaatattac 1355 NM_006558 KHDRBS3 cagccaccgaatgcttaagaactcatctaagccagtcctctcattgattg 1356 NM_006620 HBSIL ttagatttaagtctgactgaggcatgttcaaagacactacactgcctctc 1357 NM_006644 HSPH1 gctcaggctaaaaagagtcttgatcaggatccagttgtacgtgctcagga 1358 NM_006734 HIVEP2 gaactaaggctacacagagggtcgcacttggactctgagggttgggtgtg 1359 NM_006763 BTG2 tacaatccaaatttgtcgtagacttgtgcaatatatactgttgtgggttg 1360 NM_006841 SLC38A3 tgcggcatgtgcttattgccgttggcctgctcacttgtatcaacctgctg 1361 NM_006889 CD86 ataaatttgacctgctcatctatacacggttacccagaacctaagaagat 1362 NM_006892 DNMT3B agggctggagtctgcacgggacctattagagtattttccacaatgatgat 1363 NM_006986 MAGED1 tccttctaaacacagctatctagagagccacatcctgttgactgaaagtg 1364 NM_007311 BZRP cctctactgactcctccggtgagggaagctattaaagcagaaggggttgc 1365 NM_007360 KLRK1 cagagaagagattacaccagcggtaacactgccaaccgagactaaaggaa 1366 NM_007361 NID2 ctgatgagtatctcccagaacaacgatctcacctctacgggataactgca 1367 NM_012203 GRHPR gtattactcattagtgcacaagtattacttagtgcacaatatacagtctc 1368 NM_012448 STAT5B agtttcagctccgtgtgtgagatgtgcaggttttttctagggggtagggg 1369 NM_012452 TNFRSF13B actgacacctgtctgggggcgttctacgctggtgattgcccttagctcct 1370 NM_013230 CD24 actccccgaagtcttttgttcgcatggtcacacactgatgcttagatgtt 1371 NM_014246 CELSR1 agtggaacgtgccggaactttttgtccattccctagtaggcctgccacag 1372 NM_014257 CD209L cacggggtaactgcgatcattgcacttggtgttcacagtgggccaggcac 1373 NM_014338 PISD acctgcatcactaccgcaacctcagcgagttcttccggcgcaagctgaag 1374 NM_014456 PDCD4 gaattagcactggatactcctagagcaccacagttggtgggccagtttat 1375 NM_014686 KIAA0335 gggccagtcacatcagggctctccgttggtgacaaggcataattctgctg 1376 NM_014762 DHCR24 attactacaagccgtggttctttaagcatgtggagaactatctgaagaca 1377 NM_015187 KIAA0746 gaggatcctgcgttaatctatgactatgccattgtgctattcaagggtca 1378 NM_015641 TES ccctaataccaaggcgctacgtttattgcctcgtcttattcactgacctt 1379 NM_015866 PRDM2 aaaatgccttccgacgaatgggacagcccaaaaggcttaactttagtgtt 1380 NM_016076 PNAS-4 cttcacttttgctaccttgatatagcattgggctatcatgttacaacatt 1381 NM_016081 KIAA0992 accgcacttatatgcattgctagtatggaatttaagataccatacacagt 1382 NM_016187 BIN2 acacttgcctatacagagacataaccacacacactcagaggatagtgaac 1383 NM_016336 UBE2J1 tacccaacctgtagctaagaatacctccatgagccctcgacagcgccggg 1384 NM_016628 WAC gcaggcatcaagattacgcgaagaagcgcataacatgggaactattcaca 1385 NM_017530 LOC55565 cgccacctcttaatccactcggaggaccagcgatctaactgtgctgtgtg 1386 NM_017784 OSBPL10 caagttcatgggcatgtccgtgggggtctctatgataggggaaggtgtgt 1387 NM_017935 BANK1 ctcacattcagagttccagtcattattgttacatcatgtttgcagaaacc 1388 NM_017955 CDCA4 atgtcattcataaccccttgatctgtagtgtcatgggtgctgccgcaggc 1389 NM_018442 IQWD1 ctggtcaccattagaagagtcaaggatttttaaccgaaaacttgctgatg 1390 NM_018842 BAIAP2L1 ctgtgaaactccgcccgactgtgacgaatgatcgctcggcacccatcatt 1391 NM_020151 STARD7 acaagtgcgaaggagttgcggttgctccatgttctgacttagggcaattt 1392 NM_020199 C5orf15 ctcctgcttgtgtccgccgctctatccagtgttgtatcacggactgattc 1393 NM_020529 NFKBIA catgccgataagtaaacgtcgaacaattgcccttcaaccactccctctaa 1394 NM_020992 PDLIM1 tggacatcagccaaatttgaacccaatcaaatataacgtgtctgacactg 1395 NM_021813 BACH2 tgtgtgtgcaaatcctgggatgcccgtttcacgctctgacataaagacat 1396 NM_021822 APOBEC3G ctactaatccagcgacaatttgaatcggttttgtaggtagaggaataaaa 1397 NM_021950 MS4A1 accacaccccatgagggaagctctaaatagccaacacccatctgtttttt 1398 NM_021966 TCL1A gtttctgttcaccttcgtttactatgcctgtgtcttctccaccacgctgg 1399 NM_022552 DNMT3A atgtacgtcggggacgtccgcagcgtcacacagaagcatatccaggagtg 1400 NM_023037 13CDNA73 aaaaggcaatcgggcactggaccagtttaccctggcgagctttggagaag 1401 NM_024708 ASB7 aacacacggaactatgaaggacagaccccattggctgtttcaataagtat 1402 NM_025113 C13orf18 gaattccttctcaccagaggtatttgtgctgcctgttgatgtagaaaagg 1403 NM_025216 WNT10A cgagacacaacacttgtcctcttggaggttacattcttgctggggggagg 1404 NM_030666 SERPINB1 ttttctttattcggcataattcctcaggtagcatcctattcttggggaga 1405 NM_030764 SPAP1 tgatgccggcaaatattactgtagagctgacaacggccatgtgcctatcc 1406 NM_030775 WNT5B gctgtgtataagatggcagacgtagcctgcaaatgccacggcgtctcggg 1407 NM_031305 ARHGAP24 gttacaaaaggcataatcggaaatagagactacatacttgagtttatggg 1408 NM_031942 CDCA7 caatgtttgatgcataattggaccttgaatcgataagtgtaaatacagct 1409 NM_032991 CASP3 tttcttgttgctcaaaaaatgagctcgcatttgtcaatgacagtttcttt 1410 NM_033208 TIGD7 aacagaaacgctcagccggtgttccggtaagaggcgtggagcttcaggct 1411 NM_033274 ADAM19 acccccaacgcgtcctctcacaccgtccactgtgcgtttgtatgtgtctg 1412 NM_057735 CCNE2 catgtaggttgcttggtaataacctttttgtatatcacaatttgggtgaa 1413 NM_078467 CDKN1A ctgaagtgcttagtgtacttggagtattggggtctgaccccaaacacctt 1414 NM_079421 CDKN2D gcttgttttccagtctcttgtacagcgttttaaaagaaatggattctatt 1415 NM_080593 HIST1H2BK ggggcgattctcttgttgttccgatagtgtctcgcgggcgaaaccaccag 1416 NM_138340 ABHD3 ggaattccagtattgtgtctaaattctgtggatgatgttttctcacccag 1417 NM_138379 TIMD4 acgaagacggcctttttaccctctaacaacgcagtagcatgttagattga 1418 NM_139207 NAP1L1 aggtagaagtagaggcctaccttgaattaagggttatactcagtttttaa 1419 NM_139276 STAT3 gtgatatccagtggcacttgtaatggcgtcttcattcagttcatgcaggg 1420 NM_144646 IGJ gaataagcctaacacagtagaaattgctgtatggtgtagataaaacaatc 1421 NM_145804 ABTB2 ttgttcaatcactgatgggcaaaggggagatgtagctaactggtggccct 1422 NM_152785 GCET2 ctgatggccttgtacagagaacccgatgattgatgagggtatagcacagc 1423 NM_172373 ELF1 taaaccaccacgaccagattccccagccactacgccaaatatatctgtga 1424 NM_173624 FLJ40504 aaaaaattggccgtcaaaacctgagtcctgtcctcttgccctcctccccg 1425 NM_175870 LOC90925 ctgtcataaacattggatttcccgcggagtaacctggcgacatatttaga 1426 NM_177968 PPM1B atctgtattgaactttcggccctagaaaccagtggagttatttcaccaca 1427 NM_181443 BTBD3 gcaaattggtagaccttataagaaggcacttgtttgtaagccagagaaga 1428 NM_181838 UBE2D2 aaaacacagaggcattgctatttggtaagttaagcttctgtgattgtaat 1429 NM_182746 MCM4 tacattgcctacgcgcacagcaccatcatgccgcggctaagtgaggaagc 1430 NM_182776 MCM7 atatttgccaccgtccgtgaactggtctcagggggccgaagtgtccggtt 1431 NM_198833 SERPINB8 catctatgctttgtagtatgactcctgtcactcagtacaattattttgag 1432 NM_201593 CACNB2 acagttcacactgattgtgacacattcttagtagctagtgtctgttctag 1433 R99527 MGC39372 gggtcaaaccatacatcgcttcgtctctgtagtgatgacttcctgtcctc 1434 T66903 LOC54103 gtccagtgtctccctttgcataacctgctgcattgcattgacagtggagt 1435 U37028 ITGAD gctgagcatcgataccgtgtgaataacctcagccagcgagatctggccat 1436 W56129 SFRS9 tactatggagatcaacagttactgtgactgagtcggcccattctgtttag 1437 X58529 IGHM gagagggtttattacgattttgggagtggtcgattatgtactactttgac 1438 AA188785 LOC286025 gggaaggaggactccggtcttaactcccacgctaactttagctcaagtgg 1439 AA347638 BCR ttccatggagacgcagatggctcgttcggaacaccacctggatacggctg 1440 AA601122 SECTM1 gcgtttgtgtctcgggttaaaataaggttccgtccgcgtgctgggtcaga 1441 AA642467 SLC2A14 tggtcttggctttggtccacttgctgaacattttggcttcaggaagcagt 1442 AA682722 LARP agaatacctcggcaaattccgacgtcttgaagacttccgagtagatcccc 1443 AA757235 LOC399933 cttttggagtagtgtattctatgggtccagtccctttcatgcagccatta 1444 AA765313 FZD3 gatagctgtaactcacagttaacatgctttcagtcaagtacagattgtgt 1445 AB002310 HUWE1 gttaaaccagatcctacggcagtccacgacccaccttgctgatgggcctt 1446 AB002333 ZNF518 taaagaaagccatacatagaatgcttcaagctatcttgctatgcacatta 1447 AB024402 ING1 agaaatgtctcgctgatgcgggagatcgacgcgaaataccaagagatcct 1448 AB028952 SYNPO ggtttgggacttaccggggtgatgttagatctggaacccccaagtgaggc 1449 AB032991 NDFIP2 cactcgacaggttgacaacctagacagctcccccggacttgccttacttt 1450 AF008915 EVI5 aggtcattccacatcagtttgatggtgtcccagacaagctaatccaagca 1451 AF108138 C15orf20 gcacccatattttaagctgctttttcaggggataaatagtgtttggggac 1452 AF116668 LMO2 ttaggggatggtagacctttattgggtatcaagacatagcatccaagtgg 1453 AF143327 FLJ32810 attttaggactctaccgaataggaggagtgaactccaaagttcaaaaact 1454 AF200348 D2S448 cgctgctcgaagcagctgtatagcctgtgactctccgtgtgtcagctcct 1455 AF245480 MONDOA tgccgtatctgctgcagacatgattgtttcttgttctagaggttttcttg 1456 AI075159 SPTA1 gacaaagcttggagactatgccaacctaaaacaattctaccgagaccttg 1457 BU948323 TCF4 gtttatacaactgtcagtccacccagtggtgcaactggttctgattcagt 1458 AI675029 C7 tgatgctgagagcagcaaatgtgtctgccgagaagcatcggagtgcgagg 1459 AI694012 PSMA5 tgttagtgttaggctattaacaatagttaggtgaaaggtaatgagggcat 1460 AI732248 COL4A1 acgcttacagcttttggctcgccaccatagagaggagcgagatgttcaag 1461 AJ007509 HNRPUL1 tcatggataagatgcgggtgatgggcctacgccggcagcggaactatgct 1462 AK022224 ACTN1 tgtttcccgctgtgtgtatagcgtcatgccctatgcattcccacagactc 1463 AK023928 PSCD1 cataagttgcttgaaagtcgagaatggcagacatagggttgtggtgttgc 1464 AK024580 NRP1 atcatagacgagacagtccattcatcttagttaaattggattgagaatgc 1465 AK025005 MARCH1 attgtctgcagtagttaaatggcacattgtactccacgattttccaaatg 1466 AK091853 COL3A1 gggaaacatgcataagtgccaatcctttgaatgttccacggaaacactgg 1467 AK126650 CAPZB ctctgtttcatgctaaccagacacgccgtgcactcgttagattcctttct 1468 AK127124 ARHGEF4 aaaagcaaagatgccggaagccccaaaaagcccaccctagtgagtctgcc 1469 AK127132 DRG1 caacccagtcctccttaccttgcacctattaacgttggttcaacatgaag 1470 AK129940 GNAI1 agtctttcagtacacgttactggtaagtagtttccaagttacgtgttgtc 1471 AL049313 CLIC5 agtctcactacttctgacactctggttattgggcactaagggccagactg 1472 AL049327 CBLB cactctagttcaaatccacattctagttgaatccctgcaatgtaacttga 1473 AL049449 GAB1 cagtgatgtgctaatacactgatcaggtttagacaatgagctttggttgt 1474 AL050391 CASP4 taatcaacttcaaggagcaccttcattagtacagcttgcatatttaacat 1475 AL137527 LRCH3 aaacatattgagtaccggttgaaagtgtctctaccttgtgatctcggagc 1476 AL353942 SEPT11 tgtgctttcgcctttgcatgtaagtacggtagtaagaaacctttgagatc 1477 AL833915 TDRD9 cccgagcacgacatggagcttgcgtttgacgttcaattcagcgtggagga 1478 AL834278 USP30 agcttgaactgtacggtccgtcctgcactcacccgatgcagaccttgact 1479 AU252485 MAP7 gacacggaccttcatggaagtccttgctctgcgtggcatctgtcagcttt 1480 AV650179 PRG1 ggccccttgccgattttctatacccccccacaaatccctctttttacaat 1481 AV686223 KIAA1407 caagtctggtgaacgaatgagccagattagtgtaatatttaggacaggaa 1482 AW014009 MAP2K3 tctagattagtctccaccgccgtccaggacccacttgcagcatggagtcg 1483 AW190768 SLC13A3 gaagttctagaaaccgcagctgacatctcgacccaagagatttaggattc 1484 AW292143 GFAP aactgaggcacgagcaaagtgaagacactggctcatattcctgcagcctg 1485 AW439398 CCND1 aacacggctcacgcttacctcaaccatcctggctgcggcgtctgtctgaa 1486 AW452039 HRMT1L3 gatcctcatggtctgccacgtaatcattttcttagacgtttgctccacca 1487 AW615076 LOC492304 acgcagactgagcatagacagagcgcagacaatcacaaagcagaaaagca 1488 AW664012 ALOX5 ctgatttttaagacttagaataaggaggtggggaatgtgaaatatctcat 1489 AW967479 CD38 gagaaccgcgacgagcaccacataagccgtaggaccgcatgaaagaagag 1490 AW970654 PHTF2 atgagaacttatcatgttggtgtgttaggtaaatcgggcaaatatgatag 1491 BC028066 NALP1 accttggcaagatatttacccaccggccatctctgtttactcatgaatgt 1492 BC034289 LOC87769 caacttaatggcagactgtgatcgctaactgcatctggcacaaaaacatg 1493 BC042366 PCDH9 cttctcatatgatagcttatgatgccggaattctgtaaacaataaagatg 1494 BC045532 LSM8 tagtcacattagtacataggtgtcctttgcaactgctgtcaactctacat 1495 BC050383 TMPO caaaagacaagttgaagagtgagttggtcgccaacaatgtgacgctgccg 1496 BC050602 HIST1H2AC tccctatgagaacatacagagcttcctgtacacagttgcatgtactgcat 1497 BC058855 VEGF ttaaacgaacgtacttgcagatgtgacaagccgaggcggtgagccgggca 1498 BE147267 ECE1 tgatggctatagcagaatgaggtcgggtcaggaccctcaaacaccatctg 1499 BE549606 BZW1 ttcaagactgtattattcaaggcttaactgaaaccggtactgatttggaa 1500 BE798965 LAMC1 tttcattaagtggctacatcctaacatatgcattggtcaaggttgcagca 1501 BE927772 SFRS3 ggtacctaagtcttgtcatggacttacaggtttgcatgggttccaaatac 1502 BF055235 RIPK1 caggccaattccaagtcatatgcctagtctgcataatatcccagtgcctg 1503 BF513638 WNT3 ctagggtctgataggaacagacctgaggcttatctttgcacatgttaaag 1504 BG682263 HDAC3 ctatagtgaatacttcgagtactttgccccagacttcacacttcatccag 1505 BG683220 PMS2 tgttcagctgccccctagtgactccgtgtgtgaagagtacggtttgagct 1506 BG747999 MT1L aaattccgataaagccgaggttaaccggcattaaagaacgcgggaaaaag 1507 BI493513 PHF8 gtgttagtaatcaaggtttagaacaccatgagatagttacccctgatctc 1508 BI559738 GPR56 gattacatcttctctatggcaagcgtgacttcttgctgagtgacaaagcc 1509 BM709325 BCL7A tatgtaacgatataagctatcggagggtgaaccgatcaggaacgctttt 1510 BM711190 MED28 ctttgggagggtattttgctctcgttagttttgtgggcagcctcagattc 1511 BM727177 GOLT1B cactgtatctctggaagtgatgcatgaattcgattggattgtgtcatttt 1512 BQ009245 GPM6B ctccttaatagggacctgtgactccttaataaggacctgtgacatgccca 1513 BQ021469 AGPS agttcagtactgtaggaggatgggtatctactcgcgcatcaggcatgaag 1514 BQ215285 LEF1 ggcgtaggagtaacctcgcactttgctagctaacctgactccgggtgagg 1515 BQ898221 ITGA6 attagaattagagcatgggagggtcatcactatgacctaaattatttact 1516 BU929213 SESN3 gctgtagatatagtctaaggtagttaaccatataagccttttcaactctt 1517 BU954396 RPL11 ttagccattgctgcaatctctgctgttgcctcctgttctgaaaaaattaa 1518 BX095432 CNTN5 gtgtaaagataaatgatctgcttattgatagtgtcatcgaatgagcatga 1519 BX640908 EVI1 gtagcatggctctttcatataggactatttacaagactgctgagcagaat 1520 BX648339 USP53 taatggttctactaatttggactcacctgttatcgatggaaatggtacag 1521 BX648365 SEPT7 atggagattaagatgccttgaattgtctagggtgttctgtacttagaaag 1522 BX649193 TKT atggtggcgtccctgaggtagtgtagggtggaagctatggtgcagcttgg 1523 C05886 ETV6 gcgtgactcatttcaacactaagtactaggggtgttgtcaggagacaaat 1524 D31762 TRAM2 catggatgctttaattggaagtgggttgccgacccccttgtgcctagaaa 1525 D86967 EDEM1 ggtgaaaaggtagggctgagtgattaccttagccacagggtggctgagca 1526 1141942 NPEPPS aatggttaaacacaaaaggctgatagctggtatcacatagttggagtcag 1527 M60028 HLA-DQB1 cattcgaatactaaaatagtgggagtggtctttttcgtcatccctgcggc 1528 M77810 GATA2 tctcctctggcttccctctctgaaatagccgaactccaggctgggctgag 1529 N26272 MSI2 atttactaacatatgataggtattaagccactagggtcatgcctgacccc 1530 N28431 COL6A1 caccaaggaccgcctgggccggacgaatgcgagattttggacatcatcat 1531 N41620 WWP1 tgttcagaaaggtattaagggcttaggccaaatcttactttgagtatgtt 1532 N53163 COL27A1 catcagggaagcagtaccgcctggaagttggacctgcgtgcttcctctga 1533 N54946 EWSR1 ttcagtgtcttgtacaggtaaggcactcaatgttgttaacatgccctttt 1534 N70000 UBE3B tcaggtaaggcctcgccaagcctctatgcaccccacaaagtttctgcctc 1535 NM_000016 ACADM atgataaaactggtgaatatccagtccccctaattagaagagcctgggaa 1536 NM_000022 ADA gccttcgacgagcccaaagtagaactgcatgtccacctagacggatccat 1537 NM_000024 ADRB2 ttcccccactcctcttatttgctcacacggggtattttaggcagggattt 1538 NM_000033 ABCD1 tccctattcgtagccatctccgtggccaatgtgactaccgtgccagcagc 1539 NM_000062 SERPING1 gacagaggacccagatcttcaggtttctgcgatgcagcaccagacagtgc 1540 NM_000089 COL1A2 catgagtgtgatccacattgttaggtgctgacctagacagagatgaactg 1541 NM_000099 CST3 gaaaccctcaaataggccagaacaactcactaattaaattcatcccctcc 1542 NM_000110 DPYD cattaatattggtggattgcagcaatttgctactgaggtattcaaagcaa 1543 NM_000118 ENG aagtatgatcagcaatgaggcggtggtcaatatcctgtcgagctcatcac 1544 NM_000120 EPHX1 tattcctacatggttcgtgggggccactttgcggcctttgaggagccgga 1545 NM_000147 FUCA1 attttcagagcaatctaaaagcgccaaaattcgctatgtttacagtgata 1546 NM_000169 GLA ccggcaggagattggtggacctcgctcttataccatcgcagttgcttccc 1547 NM_000182 HADHA atttatcagagtaacgagaagacaaactccggcactgggtttgctccctg 1548 NM_000194 HPRT1 ttattcctcatggactaattatggacaggactgaacgtcttgctcgagat 1549 NM_000214 JAG1 gccccatctaggagagccttgattcccttgttattcaacagcaagtgtga 1550 NM_000234 LIG1 aagcagacgttctgcgaggttcccgacctggaccgaattatccccgtgct 1551 NM_000239 LYZ aaatgggagagtggttacaacacacgagctacaaactacaatgctggaga 1552 NM_000246 MHC2TA gtcagagcctcgagttattaacactaacgatttgttaatgatagctactg 1553 NM_000249 MLH1 caaagtgtaccaacataagtgttggtagcacttaagacttatacttgcct 1554 NM_000251 MSH2 cctctacctacgatggatttgggttagcatgggctatatcagaatacatt 1555 NM_000277 PAH accagacggtcgcaggcttagtccaattgcagagaactcgcttcccaggc 1556 NM_000305 PON2 agctgctcataggcactttataccacagagccttgtattgtgaactctaa 1557 NM_000341 SLC3A1 tgctgcttggtgaacaatcattaattcttcgatatttctgtagcttgaat 1558 NM_000361 THBD acaacaacaccagctatagcaggtgggcacggctcgacctcaatggggct 1559 NM_000382 ALDH3A2 gacagatggtggatggtctggacaagaagcgagtaagccactgcggttgg 1560 NM_000395 CSF2RB cccttgagaccccacgtcatgtagagaagttaacggcccaagtggtgggc 1561 NM_000417 IL2RA ataatctttgggtaacttcaaaacggggcagccaaacccatgaggcaatg 1562 NM_000418 IL4R gccagacccccaaaatcgtgaactttgtctccgtgggacccacatacatg 1563 NM_000435 NOTCH3 agtacacgacccaggtatgtaccaagtaggcacccttgggcgcacccact 1564 NM_000448 RAG1 acttatgagttggtttttgcaattgagtttccctctgggttgcattgagg 1565 NM_000484 APP cttccacataggaaagactttgacccaatgaggaattagtcattgtcctt 1566 NM_000485 APRT tgcttcttgttccttctgcgagctggtattgagcgcctgccacgagccag 1567 NM_000536 RAG2 atataccttcaagcaaccctttggattatgcccatgaacaagttagtttc 1568 NM_000545 TCF1 aacctggccttcagtgtaccgcgtctaccctgggattcaggaaaaggcct 1569 NM_000546 TP53 gggcagctggttaggtagagggagttgtcaagtcttgctggcccagccaa 1570 NM_000561 GSTM1 taagaagaactgtgcggcacagcgcccgctactacagctcgtcacacggt 1571 NM_000574 DAF aagtggaaccacttcaggtactacccgtcttctatctgggcacacgtgtt 1572 NM_000578 SLC11A1 cctcaggatttgcggagcctgtaataattgagggacaggcggggcgccat 1573 NM_000594 TNF gtgtctgtaatcgccctactattcagtggcgagaaataaagtttgcttag 1574 NM_000598 IGFBP3 gactttgtgacttaggcggctgtgttgcctatgtagagaacacgcttcac 1575 NM_000601 HGF ttgatcaactatgatggcctattacgagtggcacatctctatataatggg 1576 NM_000604 FGFR1 ggtggtgccagtggcttattaattccgatactagtttgctttgctgacca 1577 NM_000610 CD44 ttgtagtccctcacttggatatacctctgttttcacgatagaaataaggg 1578 NM_000628 IL10RB cactaaaataagatcatgttttaattgtgagaaacagggccgagcacagt 1579 NM_000629 IFNAR1 gatgttacagttcctaatttgaaaccactgactgtatattgtgtgaaagc 1580 NM_000640 IL13RA2 tatcaagagacatggtattgactcaacagtttccagtcatggccaaatgt 1581 NM_000660 TGFB1 ggataacacactgcaagtggacatcaacgggttcactaccggccgccgag 1582 NM_000700 ANXA1 gaactcgccataaggcattgatcaggattatggtttcccgttctgaaatt 1583 NM_000701 ATP1A1 agaacggcttcctcccaattcacctgttgggcctccgagtggactgggat 1584 NM_000717 CA4 agaaggtcgtctggactgtgttccgggagcccattcagcttcacagagaa 1585 NM_000729 CCK aaaggcactgccaaccccatttcacagaccgcaaaccgaggcgcgaggaa 1586 NM_000732 CD3D gtaaatgtggttgcattgtcaatagggacgctaaagttcaggccaccttt 1587 NM_000773 CYP2E1 atggacggtatcaccgtgactgtggccgacctgttctttgcggggacaga 1588 NM_000791 DHFR tcaggggttacctccatgtgccctttttagggaagctgttggagaaaata 1589 NM_000801 FKBP1A caccggacggagaacatgatgaacgacgcacatggcatagcaacgacgaa 1590 NM_000852 GSTP1 tggtgccggggcgacaaggtcgcaactataatctaaccgccttgctgctc 159 NM_000856 GUCY1A3 attagaagattttacaggacgagggctctacctctcagacatcccaattc 1592 NM_000867 HTR2B aactctcagaaaacgctccagtaagatctacttccggaatccaatggcag 1593 NM_000878 IL2RB tatctatacatccgtatcttttaatgatccgtgtgtaccatctttgtgat 1594 NM_000885 ITGA4 actgtagcaatacctttaaaatatgaggttaagctgactgttcatgggtt 1595 NM_000887 ITGAX ccaaaatgtcgtgcaccgattgttccatgcctcatatggggcccgtaggg 1596 NM_000905 NPY ttaaccttggtcagcactcggcacacccctgcgcggtgcacataacagca 1597 NM_000906 NPR1 tgaaacgtgtgaaccgtaaacgcattgagctgac&cgaaaagtcctgttt 1598 NM_000953 PTGDR acctccagccagaagtcccttccaaatataagagtactcatgtttattta 1599 NM_000960 PTGIR gtgggtgatgacgtaggacatgtgcttggtacaaaaagggcctgagacat 1600 NM_000964 RARA gggcaaatacactacgaacaacagctcagaacaacgtgtctctctggaca 1601 NM_000967 RPL3 tgataactgcaaaggggagcttggaattatgttagtcagtccctgtgaat 1602 NM_000968 RPL4 gggcttttcaagattctgctaagatctgtattaatcatcttgtgcatggg 1603 NM_000969 RPL5 ttctgccacatcacgcagagctagtgatcgagtttgcacaattacaccaa 1604 NM_000970 RPL6 gtgaaccctccacggtggaaaaaatgccgcccttagtcgggtggggaaaa 1605 NM_000972 RPL7A gctggcttaacctatgagaagttctatctgacgatcagcttggaacagcc 1606 NM_001001547 CD36 gtatgcacgtacaaatttcttaacctgttatcaatgtctgagctacataa 1607 NM_001005 RPS3 gcgtatcagaggtagcggagaatgaagagcgacaagtgggacgagctgta 1608 NM_001009 RPS5 aggaagacgagacgactagaagcacacaataagacgacaaccagacacaa 1609 NM_001015 RPS11 tagcccatatattcatgtgtcatcgttcaggaacaagtcagtgacaaact 1610 NM_001019 RPS15A cgcacatttgcatactatatgcttgttacagtgatccccacagtaactca 1611 NM_001069 TUBB2 caatactttaattgtaagaggagttccacatcattacatcaacagtgtga 1612 NM_001079 ZAP70 agtaacggtgccacgtggataccaatgcacacgcccctagagtccaccct 1613 NM_001092 ABR tctgctgatacacaggtaggatgggacccttcatgaatatctgactttaa 1614 NM_001130 AES aatgctgtatcaagggtgggcttagctgtgcctttccaataaagatgtga 1615 NM_001150 ANPEP tggtgaaggacagccagtatgagatggacagcgagttcgagggggagttg 1616 NM_001165 BIRC3 ccttgatgagaagttcctaccactgtgcaatgaataacgaaaatgccaga 1617 NM_001175 ARHGDIB tctcccccaactgatatgttcatagaatgacagtttgtagatagaagatc 1618 NM_001178 ARNTL gcaaaactctctcattgaaagcgttcacatagttcctaatgtttctttat 1619 NM_001207 BTF3 tattctttggttctgctcccccactattgaccaatgtatgagatgggaag 1620 NM_001211 BUB1B tgtattgtttggcaccaatatataaactgcttcacccttcaggatcttct 1621 NM_001219 CALU tgagaagaattatcgtattccacgtttttagccctcaggttaccaagata 1622 NM_001226 CASP6 gatagagacaatcttacccgcaggttttcagatctaggatttgaagtgaa 1623 NM_001228 CASP8 ggaggagttgtgtggggtaatgacaatctcggactctccaagagaacagg 1624 NM_001229 CASP9 accagtatcgctcatagatcagcaaaccggggcctactagagtctgaaca 1625 NM_001237 CCNA2 gactggatataccctggaaagtcttaagccttgtctcatggaccttcacc 1626 NM_001239 CCNH ttgaactaaatatccagcagatacaacaagtagtcagaagttcaaagatg 1627 NM_001255 CDC20 cgcaaagaggcaagcgcaagacgacaggaaacgaagcgagagacgagaag 1628 NM_001256 CDC27 tcccataaacaaatgtaatgggcatattgggactcgtatgtaggaatcaa 1629 NM_001265 CDX2 ttaaagccttctggatccatggggggagaagtgatatggtgaagggaagt 1630 NM_001266 CES1 ggaggagcaaagactggggtcttttgcgaaagggattgcaggttcagaag 1631 NM_001273 CHD4 aggatgcttttactacccagtggcttgtaagagacctgcgaggcaaatca 1632 NM_001274 CHEK1 atattggttgacttccggctttctaagggtgatggattggagttcaagag 1633 NM_001280 CIRBP gtgcgccccacagtagacgtgcagacgtccctgagaggttcttgaagatg 1634 NM_001295 CCR1 ggaacatagaactcatgacggaagagttgagacctaacgagaaatagaaa 1635 NM_001312 CRIP2 agtgttatttatgctcccttcgtgggtgatggccacgccctcaccatgtc 1636 NM_001313 CRMP1 ataaggatgtctaccaaatgtccgacagccagctctatgaagcctttacc 1637 NM_001337 CX3CR1 agcactcccaagtctacagagtgatagccttccgtaacccaactctcctg 1638 NM_001344 DAD1 gaccggagtaccttgcgtgcagttatgtcggcgtcggtagtgtctgtcat 1639 NM_001345 DGKA gaccgggctgcattgtgtatggtgccacctagagatccacgatgactgcc 1640 NM_001398 ECH1 ctgcagacccaagacctcgtgaagtcggtccaggccacgactgagaacaa 1641 NM_001404 EEF1G attggaccgacataggaccgtccggatgcaactctccccgtacaaccctg 1642 NM_001428 ENO1 aagtgtctagagtcatgtgagcctcgtgtcatctccggggtggccacagg 1643 NM_001436 FBL ctaggaccctcacgaacggacaacacagaagcgcaacgcgcaacacacaa 1644 NM_001441 FAAH gcagcccatgggtatgacataggccaaggcccaactaacagtcaagaaac 1645 NM_001456 FLNA aggcaacctgacggagacctacgttcaggaccgtggcgatggcatgtaca 1646 NM_001459 FLT3LG ccgtgagctgtctgactacctgcttcaagattacccagtcaccgtggcct 1647 NM_001462 EPRL1 tgtaatggtctctgaaaaggaattgagaagtaattcctctgattctgttt 1648 NM_001489 NR6A1 tcacagatgccttctctaagacagctcctgtgtacagcatcgttctttgc 1649 NM_001513 GSTZ1 ctacgagacggtgcccatcaatctcataaaggatgggggccaacagtttt 1650 NM_001515 GTF2H2 tataatggagaaagattttgttatggatgtcagggggaattgaaagacca 1651 NM_001540 HSPB1 tttaccctcgcgcgctgattatccaccctgggcgagggataccgatgtgt 1652 NM_001560 IL13RA1 taccagtcccgacactaactatactctctactattggcacagaagcctgg 1653 NM_001607 ACAA1 atgggagccgctgccgtctttgaataccctgggaactgagtgaggtccca 1654 NM_001630 ANXA8 gaaacatcgtttcaaggagcgagattgacttaaatcttatcaaatgtcac 1655 NM_001640 APEH ctgagatgctggacaaatcgcccatcagatacatccctcaggtgaagaca 1656 NM_001654 ARAF gacgtctatgcctacggggttgtgctctacgagcttatgactggctcact 1657 NM_001664 RHOA cccaccccagagctatgccaacaaaatctgttacggagtaaagccctgaa 1658 NM_001700 AZU1 ggctgagaaacagtagctatcaaacgccggctgtgagccacgtctgtgct 1659 NM_001712 CEACAM1 aggaggattagcttggagttctctatactcaggtacctctttcagggttt 1660 NM_001715 BLK caccttactggggcttagtactccggatgaccgtgcgaggtcactgttac 1661 NM_001716 BLR1 ataagctatagacccgaggaaactcagagtcggaacggagaaaggtggac 1662 NM_001728 BSG cactcccagtgcttgcaagattccaagttctcacctcttaaagaaaaccc 1663 NM_001734 C1S aatttagctatagtctagaaagttagtcgaagttaactagggagggtgtg 1664 NM_001743 CALM2 actattgcaaaacgggtgtattatccaggtactcgtacactatttttttg 1665 NM_001747 CAPG agactgcagaggaatgacgaaagcgacgggccagttgacgacgcgaagag 1666 NM_001752 CAT caggaaagtacccctcctggactttttacatccaggtcatgacatttaat 1667 NM_001753 CAV1 cgctttattggctgagatatgaacatattgttgaaaggtaatttgagaga 1668 NM_001759 CCND2 cagcagtaccgtcaggaccaacgtgacggatccaagtcggaggatgaact 1669 NM_001767 CD2 agccacacatctccataaagatgtaagaggtaattatttcagctgggtgc 1670 NM_001772 CD33 caatgcatatcattcagacataaagatgggccgaagtacagatacatgct 1671 NM_001774 CD37 tcttctgtgtggtgagtggaccgcttaccccactaggtgaagatgtcagc 1672 NM_001776 ENTPD1 attcaacaatctaaccatactgagctgctgattccccagggattgcatat 1673 NM_001783 CD79A ctaggtcgcacagggcatagacgatagtaccattcctggttgaaacacga 1674 NM_001786 CDC2 tctccagaagtattgctggggtcagctcgttactcaactccagttgacat 1675 NM_001793 CDH3 atgacgtggcaccaaccatcatcccgacacccatgtaccgtcctaggcca 1676 NM_001794 CDH4 acttggtgctatgagccctccaagtattaaccttacacagagcccccgct 1677 NM_001795 CDH5 ctgcatgacggagccgagccatgtgtctttacacctcgctgttgtcacat 1678 NM_001798 CDK2 agccttcctacacgttagatttgccgtaccaatctctgaatgccccataa 1679 NM_001830 CLCN4 ttaggtccaccatacgatctgtgtaagtaagattatcccacttgcccttt 1680 NM_001838 CCR7 tgcaaggggcgtgggagtggcctgaagagtcctctgaatgaaccttctgg 1681 NM_001839 CNN3 gtatcaatgtagagttgctctgttttcttcaactgtatttattgctgcat 1682 NM_001897 CSPG4 actggctaggggtgtcaatgcatcagccgtagtgaacgtcactgtgaggg 1683 NM_001901 CTGF tgagagtgtgaccaaaagttacatgtttgcacctttctagttgaaaataa 1684 NM_001905 CTPS ttactttcttaatgtgacctagcaataggcatagctacgtggcactatat 1685 NM_001908 CTSB cttaacaaaggttaccataagccacaaattcataaccacttatccttcca 1686 NM_001916 CYC1 aacacgacagccaacgtgcataagcatgcaacactaccgaggtagccaca 1687 NM_001923 DDB1 gcaaacctacagtatgacgatggcagcggtatgaagcgagaggccactgc 1688 NM_001928 DF agtagtgattagtcgtatttcgcgacacctcacacggtagatgtgatcaa 1689 NM_001939 DRP2 ctcttgatggagccagatccccatcctatagttcatagtcctctcctggt 1690 NM_001941 DSC3 gaatataccattcctattactgtaaaagacagggccggccaagctgcaac 1691 NM_001952 E2F6 ccaaggggttttacttaggacaagttgtaccttgccctctctccagctct 1692 NM_001964 EGRL taaacacattgaatgcgctttattgcccatgggatatgtggtgtatatcc 1693 NM_001993 F3 gattatatattccgcacttaaggattaaccaggtcgtccaagcaaaaaca 1694 NM_001999 FBN2 atgtgctattaagagcacgtatccattattcttctcaacccaagaacctg 1695 NM_002015 FOXO1A acccgagtttagtaacagtgcagattccacgttcttgttccgatactctg 1696 NM_002017 FLI1 gaaagcaaagcactggtacagttatttaacaggcatacacaagcagggaa 1697 NM_002023 FMOD tacccgtatgagacctacgagccttacccctatggggtggatgaagggcc 1698 NM_002033 FUT4 ctcctagttccacgtgctatcattctactaactggcaccctaaggttgaa 1699 NM_002046 GAPD aaaagcccctttggtgtgaaaaacggcccccacaagtttataaaaggggg 1700 NM_002049 GATA1 ccaagaagcgcctgattgtcagtaaacgggcaggtactcagtgcaccaac 1701 NM_002064 GLRX cttctggcgtaaaaacattctcgagttaataatgttaccccttataacag 1702 NM_002065 GLUL aagtcaaataactcctcattgtaaacaaactgtgtaactgcccaaagcag 1703 NM_002067 GNA11 ttattgacgcccagcgcgcctcgcctcttcacccatcaacgctgtgcttt 1704 NM_002068 GNA15 ggagcatggactttggaaccagaattctaggtgcgagtctcagctgtgtg 1705 NM_002076 GNS tcttacagttgatgcaaagtatcaactactttaccctaccttctcccctt 1706 NM_002086 GRB2 ttaatcctttaactctgcggatagcatttggtaggtagtgattaactgtg 1707 NM_002090 CXCL3 gatgttcttgaggtgaattccctgcagtgtctgcaagcactggcagcgca 1708 NM_002094 GSPT1 cttagtgactagttttcgctagacagcaggttaatacctagatctcattt 1709 NM_002102 GYPE gaagtgggatttacccattaccatatattcaccaccaggtcactgacgag 1710 NM_002107 H3F3A gcgaggacggggctttgtagaatgctcgctggtggtagctgttgttcctc 1711 NM_002108 HAL ggtgcgctctgttgtaaggccctggataaaagatcgcttcatggccccgg 1712 NM_002110 HCK caatccacaatctgacattctcaggaagcccccaagttgatatttctatt 1713 NM_002118 HLA-DMB cacatgggagatctagatgtagaaggtacacaagtagtaggataactcac 1714 NM_002121 HLA-DPB1 cagactgcaaatctgcctgataggacccatattcccacagcactaattca 1715 NM_002128 HMGB1 ctgtgcaaaggttgagagctattgctgattagttaccacagttctgatga 1716 NM_002129 HMGB2 ggtagcacagcaaacttgtaggaattagtatcaatagtaaattttgggtt 1717 NM_002135 NR4A1 ttggggccctagtggtggggctacaaggcttgctcctagatctactccaa 1718 NM_002141 HOXA4 tgtcagcgccgttaaccccagttataacggaggggagcctaagcgctctc 1719 NM_002145 HOXB2 tccttccaatgaaatctcaggaataattaaactctagggggactttctta 1720 NM_002162 ICAM3 aagaagctgcgtccgtcgtcactctcggtagcatttagctgaagttgagc 1721 NM_002166 ID2 ttggacctgcagatcgccctggactcgcatcccactattgtcagcctgca 1722 NM_002167 ID3 ctatagaggccgattatcgaagccggtacgtaaagacagcgcaagaagag 1723 NM_002186 IL9R gaacctgtcgtgcaaagctcacgtcaccaactgctgcagttatctcctga 1724 NM_002193 INHBB cacgtgaactatgcaatttaaagggttgacccacactagacgaaactgga 1725 NM_002198 IRF1 taaatgaatctcgttcccaaagaactacccccttttcagctgagccctgg 1726 NM_002199 IRF2 ctgaaacctatcgaataatcgggccgagccgcagagcacaagggaaccag 1727 NM_002222 ITPR1 agggaactttctatgcaatgttcaggataaatcgatactgctggccaatc 1728 NM_002224 ITPR3 attgtgctggtccgcgtgaagaacaagaccgactacacgggccctgagag 1729 NM_002228 JUN ttgcggccccgaaacttgtgcgcgcagcccaaactaacctcacgtgaagt 1730 NM_002229 JUNB tacacgactacaaactcctgaaaccgagcctggcggtcaacctggccgac 1731 NM_002230 JUP gccagtgatagtagttaccttgcagggtcgttgtcaggttatgtgagaaa 1732 NM_002248 KCNN1 aagacccagaccgtcatgtacgaccttgtatcggagctgcacgctcagca 1733 NM_002276 KRT19 acaggaagatcactacaacaatttgtctgctccaaggtctctgaggcagc 1734 NM_002295 LAMR1 gtaggtaggttaacataagatgcctccgtgagaggctggtggtcagccct 1735 NM_002312 LIG4 catattgaaatgtacggaatttgatccatgcgatactatgtgtgcattat 1736 NM_002341 LTB ggcagcatgagtggttaagagtcaagggagtagccggggtagtggcttac 1737 NM_002349 LY75 ttgtaaaacgtgatggatttccactatgggttgggctctcaagtcatgat 1738 NM_002351 SH2D1A tccccgtgtgtaggtagatctggtctttagaggcagatagataggtcagt 1739 NM_002353 TACSTD2 tgttaactgggcctatgtagtagcctcatttaccatcgtttgtattactg 1740 NM_002356 MARCKS taggaacttttcacttatctcatgttagctgtaccagtcagtgattaagt 1741 NM_002379 MATN1 gaagaagttcatcagtcagatcgtggatacgctggacgtgtcagacaagc 1742 NM_002388 MCM3 gctgccaaccctgtctacggcaggtatgaccagtataagactccaatgga 1743 NM_002390 ADAM11 ccacatgtcccagatcgtctccaattcgaaaacaaccgtcctgctgtccc 1744 NM_002392 MDM2 aagttgaatctctcgactcagaagattatagccttagtgaagaaggacaa 1745 NM_002393 MDM4 tagtatgggtttctaatcctaggcttgtacaatggattggagttgagcca 1746 NM_002398 MEIS1 gcgcgcatggctgaaatcctaggcgagaagaaagattcttctgcctgata 1747 NM_002412 MGMT atgtttgagcgacacacacgtgtaacactgcatcggatgcggggcgtgga 1748 NM_002414 CD99 caaagagcccgcagcgatgaaacgagactgaggcggcgaacaaacagaaa 1749 NM_002415 MIF ttttccccgcaccccctaataatcgctcgccttatatgtcccccccgcac 1750 NM_002417 MKI67 tattggctgccatgatagggttctcacagcgtcatccatgatcgtaaggg 1751 NM_002419 MAP3K11 tatcagcatgccactcgacttcaagcaccgcatcaccgtgcaggcctcac 1752 NM_002421 MMP1 cgtgtgacagtaagctaacctttgatgctataactacgattcggggagaa 1753 NM_002422 MMP3 ttttatgttattacagggcattcaaatgggctgctgcttagcttgcacct 1754 NM_002436 MPP1 tctctgcagctatcctaattcagccagtaaggttcagtcttcttgctcag 1755 NM_002441 MSH5 ctcgtggcaaggaggtctcagacttgatccgcagtggaaaacccatcaag 1756 NM_002444 MSN tcctctccagctataacagtagggatgagtacccaaaagctcagccagcc 1757 NM_002447 MST1R gagatgaatgtgcgtccagaacagccgcagttctcacccatgccagggaa 1758 NM_002460 IRF4 catctgttctatgcttcctcgtgccaattatagtttgacagggccttaaa 1759 NM_002462 MX1 tcctgtcggagccctgtctcctctctctgtaataaactcatttctagcag 1760 NM_002466 MYBL2 ttagtggttgtgaatggtgcgtgtgagatctgcatcctggcgtcaggcct 1761 NM_002475 MLC1SA tcatgacacgcgcccaccctatgcgcgttttcacaaactccgaagaacgc 1762 NM_002483 CEACAM6 actcttggtattaccctcctaatagtcatactagtagtcatactccctgg 1763 NM_002512 NME2 ctgaacacgtgcggacaacgacacgcttcgcgcgctgttggatgtaacca 1764 NM_002514 NOV agggagataactgtgtgttcgatggggtcatctaccgcagtggagagaaa 1765 NM_002527 NTF3 aataaactcgtgggctggcggtggatacggatagacacgtcctgtgtgtg 1766 NM_002530 NTRK3 gaggtcattgagtgcattacccaaggtcgtgttttggagcggccccgagt 1767 NM_002572 PAFAH1B2 tcgccgtagacagcgctctggctaccaccgtgaggctacttgaactgtca 1768 NM_002576 PAK1 ccttctcatgctctgaggtactactgcctctgcagcacaaatttctattt 1769 NM_002585 PBX1 ctgcccaagcaaatgcattataatcataagtgatccagtatttcttctct 1770 NM_002592 PCNA gatatcattacactacgggccgaacgatcacgcggataccttggcgctag 1771 NM_002600 PDE4B gttcaggcgttcttctcctagacaactataccgatcgcattcaggtcctt 1772 NM_002608 PDGFB ttccctcgtccgtctgtctcgatgcctgattcggacggccaatggtgctt 1773 NM_002609 PDGFRB agtgggttctcaatacggtaccaaagatataatcacctaggtttacaaat 1774 NM_002616 PER1 atcaggacgcactttccggctccagtgacctgctcgaacttctgctgcaa 1775 NM_002619 PF4 gggaggtggtcttcacacacaggcactgcaggtccccatcttcttcagct 1776 NM_002621 PFC ttcatgtgtcattgactccgaccttcagttacccatgcttttagctgcca 1777 NM_002648 PIM1 ttctgctgaatgccgcgatgggtcaggtaggggggaaacaggttgggatg 1778 NM_002658 PLAU aatttcagtgtggccaaaagactctgaggccccgctttaagattattggg 1779 NM_002659 PLAUR ccatgaatcaatgtctggtagccaccggcactcacgaaccgaaaaaccaa 1780 NM_002687 PNN tccgacagaaagaggtctatatcagagagtagtcgatcaggcaaaagatc 1781 NM_002704 PPBP gaagtgatcgggaaaggaacccattgcaaccaagtcgaagtgatagccac 1782 NM_002729 HHEX taagtaacttgactataaaataaagccgtccgtgggacgactgacctcgt 1783 NM_002730 PRKACA gggcgattcaacctgtgtgctgcgaaggacgagacttcctcttgaacagt 1784 NM_002744 PRKCZ tgaccatctgtggtaaccgagaattccttggaggcagcgtcttcaccgcc 1785 NM_002753 MAPK10 atgcactggggtaccacatggtccatttcatgtgatctattactctgaca 1786 NM_002758 MAP2K6 gttggaaaagaatcatgggtctcaagatcaaatgaattggaatttgcatt 1787 NM_002791 PSMA6 agtgcttctaccaacatgtcccgtggttccagcgccggttttgaccgcca 1788 NM_002800 PSMB9 aatatcagctataaatatcgagaggacttgtctgcacatctcatggtagc 1789 NM_002814 PSMD10 ggattctgtaatgttcctccatacagttaaaacatcctaacttgtttttc 1790 NM_002827 PTPN1 ttgcttacttcccccttctaaacaacaatcccaacccttacgccatggtg 1791 NM_002831 PTPN6 cacaacctgaacctaggagtgccccattcttttgtaatttaaatggctgc 1792 NM_002835 PTPN12 ccacaggaattaagttcagatctaaatgtcggtgatacttcccagaattc 1793 NM_002844 PTPRK agaaccagattgaaatgagaacgtattggtgtttgtacagtgaacatgcc 1794 NM_002856 PVRL2 ctagggttccagactggttggacttgttcgtctggacgacactggagtgg 1795 NM_002868 RAB5B ccaacataacaatcgtggtaacagaatgcgactgctgatttaccgatgta 1796 NM_002870 RAB13 aggttttagggtcctgcaaaaggctagctcggcactacactagggaattt 1797 NM_002880 RAF1 ttgagctgctccaacactctctaccgaagatcaaccggagcgcttccgag 1798 NM_002887 RARS agcagatatgattatctatgttgtggacaatggacaatctgtgcacttcc 1799 NM_002893 RBBP7 gcactttcaagtgagctgttgcgtactgtatcatattgtagctattaggg 1800 NM_002901 RCN1 catgtttgtcggaagccaagctaccaattacggggaagatctcacaaaaa 1801 NM_002908 REL tgtgcagataacagcatgataaatgagtcgggaccatcaaacagtactaa 1802 NM_002913 RFC1 agcagtaggcttatgtacacctcttatagaggttgataggactgcttggg 1803 NM_002934 RNASE2 agtaacaaaactcgcaaaaattgtcaccacagtggaagccaggtgccttt 1804 NM_002935 RNASE3 gacactatagagtgtgtcataaccgagaccggataggggagtagttactt 1805 NM_002936 RNASEH1 tgtctgtcaaggaaggtgagtggtgaagggtttttacatatatacaagaa 1806 NM_002953 RPS6KA1 gaactcattctatccccaatcagctccttttccgttctgttctgctggga 1807 NM_002960 S100A3 ccccgactgagtttcgggaatgtgactacaacaaattcatgagtgttctg 1808 NM_002961 S100A4 atgactgctgtccgcgactactcgcgttctgatgacacgtctactaaaac 1809 NM_002971 SATB1 gaggcgaggtggccttcccaatgcgcgttattcggggttattgaagaata 1810 NM_002972 SBF1 cttccgcatttctccggtcaaccgcatgtatgccatctgccgcagctacc 1811 NM_002975 CLEC11A ctgcgtgctgtgcgactgtttttcgatccgctaggtgtggctgcgactgt 1812 NM_002983 CCL3 tgcatcacgtgagtctgagtttcgttgtgggtatcaccactctctggcca 1813 NM_002984 CCL4 gtatttctccccgtccgggcgctgagtagtgtgggttatggtatgttccc 1814 NM_002985 CCL5 gcagtcgtctttgtcacccgaaagaaccgccaagtgtgtgccaacccaga 1815 NM_003002 SDHD aacgggcaatcgcctagaaacgatagagacagaacgcatgcgcgcaggcg 1816 NM_003005 SELP cacatgtcaattcatctgtgacgagggatattctttgtctggaccagaaa 1817 NM_003006 SELPLG tgcagtatcccaactgcaggtccagtgcaggcaataaatatgtgatggac 1818 NM_003009 SEPW1 caaccacggcagggaaaagcggagtacggaacgaccatcgagcacaacag 1819 NM_003025 SH3GL1 gctagcaatatcgtgtgttgcgcactcgtaaagtgtgttatttcaaccct 1820 NM_003038 SLC1A4 ttccagtctcctgtgaagccaaaagggaccaggaaccgtgcaaaggaaac 1821 NM_003039 SLC2A5 agttcccgccagggttctacacaccgtctgcaagtcagtcaagtggatca 1822 NM_003058 SLC22A2 gaatggggatcacaatggcctatgagatagtctgcctggtcaatgctgag 1823 NM_003072 SMARCA4 tctctcaacgctgtccaactgggcgtacgagtttgacaagtgggccccct 1824 NM_003073 SMARCB1 gatgcatcgctgcactcaccctccgtgctgattccgccttagttctccac 1825 NM_003100 SNX2 tgaatcaaagagtatgtctgctcccgtgatctttgatagatccagggaag 1826 NM_003113 SP100 cagacgtacacccgagtagaagggtttgtgcaggacatgcgtctcatctt 1827 NM_003118 SPARC caccagattggtgtgtcatttttagaccctttactaggcatttatagatg 1828 NM_003120 SPI1 ctacaaagtttggcccctcccaatggtaagagggacaccccccttccttg 1829 NM_003121 SPIB aatgccaatgacctagagacacgagaagtccatgtggaggcacacagcag 1830 NM_003123 SPN ctaggatcccacaccgtgacaggtggaaccataacaacgaactctccaga 1831 NM_003127 SPTAN1 agaaaatggtgcttcactaacccgcttccggtccagtcacaatcatcatg 1832 NM_003128 SPTBN1 agcatgtcacgatgttacaagaacgattccgggagtttgcccgagacacc 1833 NM_003133 SRP9 catgttgaacagcattttagcatggtaagttcccttagctatatgaattt 1834 NM_003159 CDKL5 gtaaaccaagctgcgctcctgacataccatgagaatgcggcactgacggg 1835 NM_003189 TAL1 tggccgtacttgtgatttcgatggtacgtgaccctctgctgaagacttgc 1836 NM_003200 TCF3 cagctggctggatgattgggactttaaaacgaccctctttcaggtggatt 1837 NM_003222 TFAP2C aagtggtatctgacacactctaaaccccgtgttcaaacgggggccttctg 1838 NM_003225 TFF1 cagagwzgtgtacagtggccccccgtgaaagacagaattgtggttttcct 1839 NM_003234 TFRC ggactgacatttagcgtagctaagtgaaaaggtcatagctgagattcctg 1840 NM_003262 TLOC1 tgaattctatccgtgaatcccttagaggtctgtgaattgtaggttaagaa 1841 NM_003288 TPD52L2 ctgcatcctgacccacgtgtttgtagatcctttcagctattggcgccctg 1842 NM_003302 TRIP6 ctttgattgatcactctccctgacatccacctgtatgactttgtcaccaa 1843 NM_003311 PHLDA2 tcttcacgcgcccaccgccgcaatcgatccccccttattaCcttcttacc 1844 NM_003315 DNAJC7 caaatgctaaactctactgtaatcggggtacggttaattccaagcttagg 1845 NM_003318 TTK gtactatatgacttacgggaaaacaccatttcagcagataattaatcaga 1846 NM_003352 SUMO1 gccgatctacagtcattcaccgggggtaggagagtcacacaagtacaacc 1847 NM_003361 UMOD tctgggaccagattccgaagtgggagtgtcatagatcaatcccgtgtcct 1848 NM_003383 VLDLR ttcagctttggatgtggttaccgagtatctgtaacccttgaatttctaga 1849 NM_003390 WEE1 gcatctatgccgatctatgccgatctaagttgagcatcagtatggtgacc 1850 NM_003395 WNT9A ccgccgtccctgtgttatagtacataagaacccttattctcctgtggttc 1851 NM_003403 YY1 agcactaggactctagcctgcatttaggaagacttgccattttgccaagt 1852 NM_003415 ZNF268 cctgtcacttccagcgaggcacacaaaactgaccgtagggatggccacca 1853 NM_003425 ZNF45 atggtttggtcgtaggatcagcagggctcgcacttcggtcagcaggaaaa 1854 NM_003427 ZNF76 agagtccgccacccaaacgaccccggatagcttacctttcggaggtgaag 1855 NM_003453 ZNF198 tacagagttgcttacaatgacggatatgatgagtgaagacgaggggaaaa 1856 NM_003467 CXCR4 ggagtgggttgatttcagcacctacagtgtacagtcttgtattaagttgt 1857 NM_003480 MFAP5 agaatatcttcacgaacttgaccctcctactccacattgcaacatttcca 1858 NM_003549 HYAL3 ggagggaaccttgggtaggtttgagcagggggtatagtgtctgctttgca 1859 NM_003582 DYRK3 atgaaggagaccagttggcctgcatgatggagcttctagggatgccacca 1860 NM_003627 SLC43A1 tcagtgctgtgttcgccttgcttcagcagccacttttcatggcgatggtg 1861 NM_003636 KCNAB2 gcagtttgggagccacaaaaagcgtagcggtgtgatttctagctcagcct 1862 NM_003645 SLC27A2 gaggaaattttgtaggaaatttgcatacccgtaaagggagacttttttaa 1863 NM_003692 TMEFF1 acagactttagtattctctatgtagtgccaagtaggcaaaagctcactca 1864 NM_003701 TNFSF11 actaatggtgtacgtcactaaaaccagcatcaaaatcccaagttctcata 1865 NM_003707 RUVBL1 tgccatgttaaatatccctatctgtcggacacctgtatacatataagttt 1866 NM_003739 AIKR1C3 atttcacacaagacttctcccgccgtattggttgcggaccttgcgcggcc 1867 NM_003746 DNCL1 gataaaacgccgaacggaacacgaactgcgacactgaaagaacccacccg 1868 NM_003753 EIF3S7 tgtccgttgtgagcacgatggcgtcatgactggagccaacggggaagtgt 1869 NM_003801 GPAA1 ttctggaatgtgctcttctggaagtgagatctgcctgtccgggctgggac 1870 NM_003805 CRADD tggtagatctaaataccataaatggtggctagctttataggaaaacccat 1871 NM_003821 RIPK2 ccatatgatatacctcaccgagcacgtatgatctctctaatagaaagtgg 1872 NM_003824 FADD gatttcctgtagtgaatcaggcaccggagtgcaggttcgggggtggaatc 1873 NM_003842 TNFRSF10B acattgtaagatccatctacacagtcgttgtccgacttcacttgatacta 1874 NM_003852 TIF1 gtaggttagatgctattaagaaggcacttaatagtacatcatgtaagatg 1875 NM_003874 CD84 tagactcatctagcaccaactaccattagcactatgttaggagctgcaag 1876 NM_003877 SOCS2 agaggactgaccatattaaagagttagggctactaacctcaaaaagtttc 1877 NM_003879 CFLAR gagcaagcccctaggaatctgcctgataatcgattgcattggcaatgaga 1878 NM_003884 PCAF ggtcataaccccctaaaatccatcatgcaaccttattaatctgtcttggg 1879 NM_003900 SQSTM1 cacatgtgaactttttctaggtggcaggacaaatcgcgcccatttagagg 1880 NM_003902 FUBP1 ttcgtggcactccacaacagatagactatgctcggcaactcatagaagaa 1881 NM_003914 CCNA1 tgagtgagcttcataaagcgtaccttgatataccccatcgacctcagcaa 1882 NM_003954 MAP3K14 cacgtagcattaaatcagctgtgaatcgtcagggggtgtctgctagcctc 1883 NM_003955 SOCS3 tgtcagcccagtaagtattggccagtcaggcgcctcgtggtcagagcaga 1884 NM_003974 DOK2 ctggccctacaggtttctgcggcgctttgggcgggacaaggtaacctttt 1885 NM_003998 NFKB1 cgcaaactcagctttaccgagtctctgaccagtggtgcctcactgctaac 1886 NM_004039 ANXA2 agacagacgagacacgacagaccggaacgcacgaccaccgaacaagcaac 1887 NM_004047 ATP6V0B ttgctgcgtgttgatttggaggcactgcagtccaggCcgagtCctcagtg 1888 NM_004064 CDKN1B agacggggttagcggagcaatgcgcaggaataaggaagcgacctgcaacc 1889 NM_004067 CHN2 cagaagtgacatcctattgctttcaccatgttttatctgttagaagcaaa 1890 NM_004077 CS acctctttttgaacagggaattgattcaagattggacatggtctcctctg 1891 NM_004083 DDIT3 atgatgtgaccctcaatcccacatacgcagggggaaggcttggagtagac 1892 NM_004088 DNTT gtaatgggtaaggttctaataggccatgtttatgactgttgcatagaatt 1893 NM_004093 EFNB2 cagcttgtttaacggcagtgtcattcccctttgcactgtaatgaggaaaa 1894 NM_004099 STOM cttgcctgtacttgtcagaactagaggaaatagccaagactaatgaaaaa 1895 NM_004104 FASN gacattccacggggtcctactggatgcgttcttcaacgagagcagtgctg 1896 NM_004111 FEN1 cagaggagtaagatggtgatgttcacctggcaatcagctgagttgagact 1897 NM_004119 FLT3 aaacctcaagtgctcgcagaagcatcggcaagtcaggcgtcctgtttctc 1898 NM_004177 STX3A gggcattttagcattgattattggactttccgttgggctgaattaagagt 1899 NM_004208 PDCD8 ggcgggtagagcaccatgatcacgctgttgtgagtggaagattggctgga 1900 NM_004221 NK4 caaaaccctcaagaactgacagcattacactgaacaccgacaccaagagc 1901 NM_004235 KLF4 caatggtttattcccaagtatgccttaagcagaacaaatgtgtttttcta 1902 NM_004310 RHOH ttgcttccctttccccacaagaacaaagcactggccgggtaaggtggctc 1903 NM_004313 ARRB2 tattcaccctgggcgcgcgtccactccccggatgttttctgtgcaatcga 1904 NM_004320 ATP2A1 aatcctcaagttcgttgctcggaactacctagagggataactgttccccc 1905 NM_004324 BAX tgccggaactgatcagaaccatcatgggctggacattggacttcctccgg 1906 NM_004335 BST2 ggtagtacttcttgtccgcgattctcacgcttaagacctggttttctctt 1907 NM_004336 BUB1 ttccagaatggcagtgtattagtaggagagctctacagctatggaacatt 1908 NM_004343 CALR gacgggtggacttcccgctggatcgaatccaaacacaagtcagattttgg 1909 NM_004355 CD74 cagtcatggatgaccagcgcgaccttatctccaacaatgagcaactgccc 1910 NM_004374 COX6C ttgttaggtgggtgtccacgagtgactagctgtctttccataggtctggt 1911 NM_004380 CREBBP caagcgctctaattcctataaatacgaaactcgagaagattcaatcactg 1912 NM_004385 CSPG2 gcaagataccgagacatgtgactatggctggcacaaattccaagggcagt 1913 NM_004413 DPEP1 tttcgggacgaggcagagaggatcatgagggactcccctgtcattgatgg 1914 NM_004425 ECM1 cttgtggtaaggttgggttcttgatgccggggggtgtcctttaaccccag 1915 NM_004430 EGR3 cctcgctccttctggtatatgcatgtcactgcatgataattgagttttcc 1916 NM_004448 ERBB2 tgttaggagcctcaaaaccttcttgtatcccttttacagtcaaagtccaa 1917 NM_004449 ERG catttggggactgtgtacaatgagttatggagactcgagggttcatgcag 1918 NM_004454 ETV5 taaggggtgcactttatagctatggaaacatgagattctcctctattgga 1919 NM_004475 FLOT2 aacaacgggaacgttactgactctggtgccttatctcgaagggaccagaa 1920 NM_004494 HDGF gtagctttggaagtttagctctgagaaccgtagatgatttcagttctagg 1921 NM_004501 HNRPU gggtaagctaaatcatagtttctgacaataactgggaaggttttttctta 1922 NM_004508 IDI1 aagcaatccagccgagcttgaggaaagtgacgcccttggagtgaggcgag 1923 NM_004513 IL16 agatgaacataatctaccaacgaaagacgtgattcaattcaacactccct 1924 NM_004526 MCM2 aactaccagcgtatccgaatccaggagagtccaggcaaagtggcggctgg 1925 NM_004530 MMP2 cccctgttcactctacttagcatgtccctaccgagtctcttctccactgg 1926 NM_004557 NOTCH4 atgtaagatgttctttcctatatatggtttccaaagggtgcccctatgat 1927 NM_004583 RAB5C gggcatactctgcgttaaggtggacgttttgaccgagtcgatgcgccgtt 1928 NM_004615 TM4SF2 tgatttaatgtagtactctgcttctgtatccccgaggtgagtcagaaaaa 1929 NM_004624 VIPR1 ccagaagatcccctcaggactgcaacaggcttgtgcaacaataaatgttg 1930 NM_004633 IL1R2 atttctaagtgtgagggggaccactcacttactcgtacacgatgtggccc 1931 NM_004642 CDK2AP1 cccaccaaacctaacaaggacccccgaacactttcatactaagactgtaa 1932 NM_004688 NMI tccaggactcatattggcgactggtaatcgggatataactaaaagataga 1933 NM_004689 MTA1 ttggaatatatggtccaatgaagcacatccctcgcgcccgacccgccctg 1934 NM_004706 ARHGEF1 ttttgcaagaaggagaggaatgggggagaggacgtgagggaccaccccca 1935 NM_004725 BUB3 aacaattgatcccagaagggcaaattgtttgagtcagtaatgagctgaga 1936 NM_004815 PARG1 tatttttgatccggattacatcaaggagttggtgaatgatatcaggaagt 1937 NM_004827 ABCG2 acctccttctgtcatcaactcagatgggtttccaagcgttcattcaaaaa 1938 NM_004867 ITM2A tggtgaaaatcgccttcaatacccctaccgccgtgcaaaaggaggaggcg 1939 NM_004924 ACTN4 aatgaagacatagccgattctctgcccgggccccttgctgatgctcctcc 1940 NM_004936 CDKN2B gctggaacctagatcgccgatgtagatttgtacaggagtctccgttggcc 1941 NM_004938 DAPK1 agcagcatcatgtgcttcgggtgtcacgacgtctactcacaggccagcct 1942 NM_004941 DHX8 gattgccaccaatatcgcagagacatcgctgactattgatggtatctact 1943 NM_004972 JAK2 caataatgtaaatcaacgcccctcctttagggatctagctcttcgagtgg 1944 NM_004994 MMP9 ttctgccaggaccgcttctactggcgcgtgagttcccggagtgagttgaa 1945 NM_004997 MYBPH aataccgcgccctctctgagcaaggcgtctgcaccctagagatccggaaa 1946 NM_005012 ROR1 gagtgtttagaaagtgtaagggctctgcaactaaaaggacctgacctaga 1947 NM_005080 XBP1 cagctgattagtgtctaaggaatgatccaatactgttgcccttttccttg 1948 NM_005084 PLA2G7 caacacatcatgttacagaactcttcaggaatagagaaatacaattagga 1949 NM_005085 NUP214 atccttcggcacgctcgcgagtcagaatgcccccactttcggatcactgt 1950 NM_005098 MSC tccaaaaagagcttcctttcgtgacgagacgcggacgcaggtccaccctc 1951 NM_005104 BRD2 atccacctccatccgcttggaaatggccttcgtcccggcctatgactggt 1952 NM_005123 NR1H4 gttccttcgttcagctgagattttcaataagaaacttccgtctgggcatt 1953 NM_005157 ABL1 ttcatccctctcatatcaacccgagtgtctcttcggaaaacccgccagcc 1954 NM_005161 AGTRL1 gaccgtgaggatgaaattaatagtggggcctttgtgagctagaggctggg 1955 NM_005178 BCL3 tgaacctgcctacacccctataccccatgatgtgccccatggaacacccc 1956 NM_005187 CBFA2T3 gcctgaagctgagcgtgtacgttaatgtgaatgtatatagtctttgcaga 1957 NM_005192 CDKN3 taccgaaaaaccttaatacactgctatggaggacttgcgagatcttgtct 1958 NM_005197 CHES1 acacttttgctatataacctaagtgataaccctcttttagttacctgcca 1959 NM_005215 DCC aattttccgggaactttgcagcataccaattacccataaacagcacacct 1960 NM_005225 E2F1 aaggaactgaggcctgggtgatttatttattgggaaagtgagggagggag 1961 NM_005230 ELK3 ctgtcagcatggaaagtcgggggctttcgcccgggtcctcctagaaattc 1962 NM_005239 ETS2 ttacatttaatagacttacagggataaggcctgtggggggtaatccctgc 1963 NM_005245 FAT ggatacatcagattggatgccaagcgttcctctgccggacatacaagagt 1964 NM_005246 FER tcattagacgctgctgctggtatgttgtatctcgagagtaaaaactgtat 1965 NM_005248 FGR tcccctacccaggcatgaataaacgggaagtgttggaacaggtggagcag 1966 NM_005252 FOS attgttgaggtggtctgaatgttctgacattaacagttttccatgaaaac 1967 NM_005263 GFI1 agactattccctccgtttagagaatgtaccggcgcctagccgagcagaca 1968 NM_005317 GZMM tccaagtgctggacacccgcatgtgtaacaacagccgcttctggaacggc 1969 NM_005318 H1F0 ctacaaggtgggtgagaacgctgactcgcagatcaagttgtccatcaagc 1970 NM_005334 HCFC1 taacccctgtgactcaatattaccatagtgcgatgtcgttttgtgctatt 1971 NM_005335 HCLS1 cttttgtgaggattcgttaggaagaaaagcgctaagttagtgaatgaaac 1972 NM_005339 HIP2 gtgtctgctggaagtctactgccattatagggaaccttgcttgttagctt 1973 NM_005340 HINT1 gttcaaagattagagcgagtacttaatggtaaaataccgtcttatatgca 1974 NM_005356 LCK catatgcaccttgtgtctgtacacgtgtcctgtagttgcgtggactctgc 1975 NM_005375 MYB ttggtcacaaattgactgttacaacaccatttcatagagaccagactgtg 1976 NM_005385 NKTR gtgtacttaatcaccttagtgccagtttaatccagttatgcagaagaaat 1977 NM_005424 TIE1 atgaagtgtacgagctgatgcgtcagtgctggcgggaccgtccctatgag 1978 NM_005427 TP73 cagtcaagccgggggaataatgaggtggtgggcggaacggattccagcat 1979 NM_005439 MLF2 tctcaatttaccacccaaacgcgccaccgacccgatcccatcgtgaccga 1980 NM_005494 DNAJB6 gccagtttcattctgacgagctctatagtagtccggtgtggacctctgcc 1981 NM_005504 BCAT1 taacaaggaataatcccacaatatacctagctacctaatacatggagctg 1982 NM_005521 TLX1 aagggcccccacatttgtgccgacactgttctccttcggtggaagagctc 1983 NM_005529 HSPG2 aggagtctctgccacccactcaggattgggaattgtctttagtgccggct 1984 NM_005533 IFI35 ttcgctctctccgctcctatacctctatctgtcgtgcttaaacctctgct 1985 NM_005556 KRT7 tgtctgcagtggagagagggggagggcacacatgtggaagcttcggaaag 1986 NM_005563 STMN1 cgcccgaagagcctcagtgcttacactaaggagtcgtcttctatgcaata 1987 NM_005566 LDHA cgtccctctttttgttggttaccccattatcgtttgccctagcccccgcc 1988 NM_005572 LMNA agtgcgtgaggagtttaaggagctgaaagcgcgcaataccaagaaggagg 1989 NM_005583 LYL1 cttgaccctaggaagtgcccggcgtaccagtaccttcgccatccttttgt 1990 NM_005589 ALDH6A1 caatgaaaccagatttctcacttgctcttcatacttctattttgaggtaa 1991 NM_005608 PTPRCAP aagaattccaagggagcggacagtggcacgctgtgattgacacccaggcg 1992 NM_005621 S100A12 aaaacccagccttgcccgtggggagtaagagttaataaacacactcacga 1993 NM_005651 TDO2 aatctttcaacatacctgattccccgacactggataccgaagatgaaccc 1994 NM_005654 NR2F1 agcccacccagcagaaatacaatccgagctacaaagcatgggaaaaagag 1995 NM_005671 D8S2298E caaagctcttggaggctttaaagttctttctgttgggtgtgcattacagt 1996 NM_005687 FARSLB tggaccctttttgtgaagattggtctctgtggtgtgattctcttcccagg 1997 NM_005730 CTDSP2 cagagccagcctagtcattatttgctgtcgggtttccagtttcaccgtgt 1998 NM_005731 ARPC2 gtttcttggtaaatccagaatcaggatacaatgtctctttgctatatgac 1999 NM_005738 ARL4A agctaagctggaagggtgcttatccctgcgtagaaacgcctgccaatgct 2000 NM_005761 PLXNC1 ttccggaattcagtactgtggcattaaacgtcgtctttgaaaaaatcccg 2001 NM_005767 P2RY5 acccgccgtttttgttcagtctacccactctcagggtaacaatgcctcag 2002 NM_005781 TNK2 ctacctcagaatgacgaccattacgtcatgcaggaacatcgcaaggtgcc 2003 NM_005794 DHRS2 ctgccagactagcaatttgggggcttactcatgctaggcttgaggaagaa 2004 NM_005808 CTDSPL tgggaatcgaacctagggatagtgctccacttctgacgatggagtgaaga 2005 NM_005809 PRDX2 aacttaccgatcatcgcacgccggagttcgatcacgagaccgacggggaa 2006 NM_005826 HNRPR tgaaactgtgtgacagctatgaaattcgccctggtaaacaccttggagtg 2007 NM_005835 SLC17A2 ttgtccaggaatcttctcagattgatcactgtgcgaaagctcttttcatc 2008 NM_005845 ABCC4 cacttccaatggacagccctcgaccttaactattttcgagacagcactgt 2009 NM_005870 SAP18 tgtacttaagcatcactcaagggtaagtgttctaggaaggttgatttagc 2010 NM_005895 GOLGA3 gtgtgtcacaacaggctagggcacttcacgatgtcactacttgtttttct 2011 NM_005900 SMAD1 ctgctattctgaaattgcctacatgtttcaataccagttatatggagtgc 2012 NM_005902 SMAD3 agacacatcggaagaggcgtgcggctctactacatcggaggggaggtctt 2013 NM_005907 MAN1A1 tcatttgatccgcaagtctagcagcggactaacttatatcgcagagtgga 2014 NM_005911 MAT2A agggagtgttccctatccaatcaatcttgcatgtaacgcaagttcccagt 2015 NM_005923 MAP3K5 gatgtttgccttagacagtatcattcggaaggcggtacagacagccatta 2016 NM_005933 MLL attgtcatctttgccatgcgtaagatctaccgaggagaggaactcactta 2017 NM_005936 MLLT4 cttgagcggcatcgaatagaggcagctatggaccgaaagtctgatagtga 2018 NM_005944 CD200 ggactgtgaccgactttaagcaaaccgtcaacaaaggctattggttttca 2019 NM_005954 MT3 tttttcaccggggcgtggctaccctgtcgtgacgcgtttccgcgtattgt 2020 NM_005956 MTHFD1 aaaggtgtccctacaggcttcattctgcccattcgcgacatccgcgccag 2021 NM_005957 MTHFR ttggagcccgtgcagtacaggcaaaacacgcaagggcatcaggcactggt 2022 NM_005965 MYLK cttatttgtgctgttatagaatatcagctctgaacgtgtggtaaagattt 2023 NM_006005 WFS1 ttcagccactcaggaccctggctttctgctccaaggcactgaacacagtc 2024 NM_006017 PROM1 gagattttcatctattatactttatcaaagattggccatgttccacttgg 2025 NM_006038 SPATA2 cgtaacttaccctatggacaaaagcaggaatgactaacacatcctaggag 2026 NM_006060 ZNFN1A1 tgtcgcttcctagaatccccttctccaaacgattagtctaaattttcaga 2027 NM_006079 CITED2 cccagcagagtgagctgttgactcgatcgaaaccccggcgaaagaaatca 2028 NM_006082 K-ALPHA-1 cttcaattaccctctacaccattattacacattcacacaac 2029 NM_006084 ISGF3G ataattctcagtagttgtccgtgataatcgtgtcctgaaaatcctcgcac 2030 NM_006098 GNB2L1 tgttgaaatgagagcggtttcttacagtctacccggcgttgtggcacatg 2031 NM_006101 KNTC2 actacaccataaaatgctatgagagttttatgagtggtgccgacagcttt 2032 NM_006113 VAV3 cctgttagagaccctcatgggctaggacttttcatctaggatagattcaa 2033 NM_006120 HLA-DMA gcagaccctaatctctcctcaccgacagatggcacttcacagaacagaaa 2034 NM_006142 SFN gtgacgacaagaagcgcatcattgactcagcccggtcagcctaccaggag 2035 NM_006152 LRMP gcaagaggactcatggacgtctctagaacatatcttgtggccatttacca 2036 NM_006184 NUCB1 ttgtggaaccagtgatgcctcaaagacagtgtcccctccacagctgggtg 2037 NM_006185 NUMA1 aagagccagacagcgccaactcatcgttctacagcacgcggtctgctcct 2038 NM_006187 OAS3 atggcgctggtacgtaaatagaccaatgcagttaggtggctctttccaag 2039 NM_006190 ORC2L ttgatcagcctggctggtaccgtctagtactatgcagcggtcctcaagtt 2040 NM_006191 PA2G4 cagagttgctgagttcagtattgctaatgcagtatttttcattgtgcctt 2041 NM_006196 PCBP1 tctcccagtctccgcaagggagagtcatgaccattccgtaccagcccatg 2042 NM_006209 ENPP2 ggcttgtgttgtaatagtgtgggccgctttgtctcaaatccgcagttcta 2043 NM_006216 SERPINE2 taacttgctggccttatgcttacatggtctcatgtaatgtgcacaacaca 2044 NM_006230 POLD2 acattttcagcgttggctgagttacatgtacagtgcttaggccacctggg 2045 NM_006231 POLE agacaaccaggtgatgcacttctaccgctggcttcggtcgccatcctctc 2046 NM_006235 POU2AF1 agcctaaaggtgatgggtcctcgcctaggcttagtgctaccatgtgggtt 2047 NM_006255 PRKCH cccaaagggaatagagattctccaggaatttcctctatgggaccttccca 2048 NM_006263 PSME1 ggctgcgataagtgaagagttgaaccacacaacccgcgttgtgaataatt 2049 NM_006268 DPF2 aaaggagcaacacactgcccctaggcgtgcgtgtggcccagtttctctct 2050 NM_006273 CCL7 tttgggttttcttgtccaggtgcttcataaagtcctggacccacttctgt 2051 NM_006286 TFDP2 gagattgctacacggagcagtccttgacgatcgtgtttctgacgtttctc 2052 NM_006299 ZNF193 tttcagtttcatattacccctatatgcatcaaagctgcaacttcccttgc 2053 NM_006301 MAP3K12 actgctgactggtgagatcccctacaaagacgtagattcctcagccatta 2054 NM_006302 GCS1 tgcctgtagcccatatgctagaggttggtgaccctgacgacttggctttc 2055 NM_006325 RAN gcattcttcttacttccccgtacgctttctgtgctattccgcctccccct 2056 NM_006329 FBLN5 tcctcatcttttcgcaccaccaagcctactaatgcccacgggctctcagg 2057 NM_00634-3 MERTK tgacgttcggaaccaagcagacgttatttacgtcaatacacagttgctgg 2058 NM_006354 TADA3L gctgaaggcacttagtgcccacaaccgcaccaagaagcacgacctgctga 2059 NM_006355 TRIM38 ctatgaggccggagttgtatccttttataacgggaatactggctgccaca 2060 NM_006362 NXF1 gaagcagtcccccctgtaaatagtccttggatattaccgtctggttgtcg 2061 NM_006427 SIVA ccccatgtcagtgccgtcatctagactgattatgcccgcagtgatcctgt 2062 NM_006472 TXNIP cctattgcactgtgttctcctactgcaaatattttcatatgggaggatgg 2063 NM_006495 EVI2B gataatacaatcatttccaccgcttgactcacttaacttgcccctgccac 2064 NM_006509 RELB tctgacccccatggcatcgagagcaaacggcggaagaaaaagccggccat 2065 NM_006522 WNT6 taaaggcctctggatactgggctccccagaactgctggccacaggatggt 2066 NM_006534 NCOA3 ctccaaggaatgcacccacgagccaacatcatgagaccccggacaaacac 2067 NM_006559 KHDRBS1 tgatacatacgcagaacaaagttacgaaggctacgaaggctattacagcc 2068 NM_006565 CTCF tttaagagagccatcagttagctatcagactctaggttgatgcattttgt 2069 NM_006579 EBP ctaagtgaccgccccacctgtggcttatacgtggcgtggcctctttcttc 2070 NM_006591 POLD3 cccaatatgctgcctcaactctgagctgtctgcaaggcttagtaagtatt 2071 NM_006602 TCFL5 caagccatcgtggttggctggaactagacgtgtgatttgaatgcaggagt 2072 NM_006676 USP20 ttctttgccgctgatgagttaaagggtgacaacatgtacagctgtgagcg 2073 NM_006739 MCM5 tgctggccaagcatgtcatcactctgcacgtgagcgcactgacacagaca 2074 NM_006747 SIPA1 cctctcagagaaggtctctcacttggagtccatgctcaggaagctgcagg 2075 NM_006748 SLA tggaactactttaactaatccatagggacttctggtatgctttcctctct 2076 NM_006759 UGP2 aaataaaacacgtgcagatgtaaagggcgggacactcactcaatatgaag 2077 NM_006762 LAPTM5 tgtcgctggccatccattcagtcgattcagtcataggcgaatctgttctg 2078 NM_006769 LMO4 ctgctaaaaggtcagagtaatgcagaatgcgtgccttcatctcagatttg 2079 NM_006803 AP3M2 tcaaagaccatgatggtatcggactagttttcagacactgcctgttgctg 2080 NM_006820 IFI44L ctagtgttcatggaggtagcattgaagatatggttgaaagatgcagccgt 2081 NM_006825 CKAP4 gtcggcaaggagcgtgcatactgcgtttgtgtaattgtttgctgtatctc 2082 NM_006845 KIF2C ctccaaaagaaagtcttcgaagccgctccactcgcatgtccactgtctca 2083 NM_006857 RY1 ttggtaaacattggcttgcctcccatgacttgccattataattaaaactg 2084 NM_006875 PIM2 ctaccaccacacaaacttagttcatatgctcttacttgggcaagggtgct 2085 NM_006904 PRKDC ggatcgactttgggcatgcgtttggatccgctacacagtttctgccagtc 2086 NM_006910 RBBP6 aggctagaacgtcagataaacatgattccactcgtgcttcctcaaataaa 2087 NM_006931 SLC2A3 aacttcatgtcaactttctggctcctcaaacagtaggttggcagtaaggc 2088 NM_006932 SMTN agagcgactgcacataggggaaaacacacttggggtcaggctttttgccc 2089 NM_006937 SUMO2 ttttttgtacgtagctgttacatgtagggcaatctgtctttaagtaggga 2090 NM_006938 SNRPD1 aactgtaaccattgaattgaagaacggaacacaggtccatggaacaatca 2091 NM_006963 ZNF22 tggggcatgactattcgatttgactcaagcttcagtagactcagaagaag 2092 NM_006981 NR4A3 ggattagtgggctgcgtttcaacattccgtgttcgtactcccttttgtat 2093 NM_006994 BTN3A3 acatggctcgtggagagaagtctttggcctatcatgaatggaaaatggcc 2094 NM_007022 CYB561D2 ttcaggctacaaccactagcacggctgacgatggccctttctgcggagac 2095 NM_007063 TBC1D8 ttcaaccaccgagtgatcggggcacaagttgaccagtctgtcttcgagga 2096 NM_007065 CDC37 ttctatttggcaaacagcaatgatcttccaataaaagatttcagatgctc 2097 NM_007079 PTP4A3 ttattagaccccggggcagtcaggtgctccggacacccgaaggcaataaa 2098 NM_007117 TRH ggtgtcccaacgtataaactatcacagtagcgctcatggctcgtaggttt 2099 NM_012092 ICOS ttgtaatttgaatctagtatggtgttctgttttcagctgacttggacaac 2100 NM_012120 CD2AP caggttttacgatgtataatttacctaatagaccaaactaactcatggag 2101 NM_012207 HNRPH3 caacatacaatcttacaacacatcttctactaactttcttaca 2102 NM_012223 MYO1B cgaccattgctgcatattggcatgggacccaggtacgtagagaatacagg 2103 NM_012267 HSPBP1 acacagttgccctaatgcggctggaatccccattgggggtaggtgagcag 2104 NM_012317 LDOC1 gtcttacatgctcgtgaacgagaaccgattctgcaacgacgccatgaagg 2105 NM_012323 MAFF cctccccactgtttatttattgcacggatctaagttattctccccagcca 2106 NM_012334 MYO10 tacagatataataaccatgttgactatgggggagagacgctgcattccag 2107 NM_012384 GMEB2 ccaaaataatggtgagtgcctaggcttcccgagttagctctttgggtggc 2108 NM_012417 PITPNC1 atatccaggagattcattaggtcatcagcgatcaaaggttagcattttat 2109 NM_013282 UHRF1 gggctgtacaaggtcaatgagtacgtcgatgctcgggacacgaacatggg 2110 NM_013314 BLNK taagaagctcatgtggacttgttctattgcctgacctgatgaactgttaa 2111 NM_013416 NCF4 atcctccttttgtcttcacctcgatgacgaaaacctaaggaggacagagg 2112 NM_014005 PCDHA6 cgccctaagtcctccagtctccttagagctagtacttactaagcatttac 2113 NM_014207 CD5 catctatagtttggccaccatacagtggcctcaaagcaaccatggcctac 2114 NM_014232 VAMP2 gaagttcagtatgttatgatggaccaataattctgcccttcgggtttctc 2115 NM_014244 ADAMTS2 accctctccgcccttggggtaatgtactttgtgatattgccacccgcccc 2116 NM_014298 QPRT ccacatggggttctgcggtgataatgagcacatagtgaggggtcagcaaa 2117 NM_014345 ZNF318 attgaactcattccctgttccacaaacccatatgtatcctttcctcaacc 2118 NM_014365 HSPB8 tccctccgcggattctccggggctggttcatcacctccgaatattcctgt 2119 NM_014575 SCHIP1 atgtgacctgctttcgatcataagactgtgttaagaccttctcctcagtg 2120 NM_014595 NT5C tttacggcagacgtacccccgttcaccccacgttactagtaggggaccga 2121 NM_014614 PSME4 acccagcgatgtgttgcagaaattatagctggtttaatcagaggttctaa 2122 NM_014624 S100A6 caccactacgcgcacgcagcgatataggcatcgcacctctatcatcgtca 2123 NM_014667 VGLL4 agtcctagatatacttactgctggtacagttgtactctaagattggtatt 2124 NM_014707 HDAC9 ttcctactgagtaaatcagcaacgaaagacactccaactaatggaaaaaa 2125 NM_014724 ZNF305 ctacctttatattctccaacacaagaccgtgtaggtgtcccttcagagag 2126 NM_014734 KIAA0247 aagtctttccatcatagcaggcgtgaccagggggtatctggggaccaggt 2127 NM_014735 PHF16 gaacaaaatcgtatccgagatacccactagagagcaagaataaccgtttg 2128 NM_014780 CUL7 gggtgaagacggccagaacttggagaagagacggaatcttctgaactgcc 2129 NM_014792 KIAA0125 aggagaaaacacggtaacgtaattagaatagtcagagaaaagtagccaga 2130 NM_014824 FCHSD2 gtatccttagaatccaaatgtctagataagttgaggacacatacctgcat 2131 NM_014890 DOC1 actgcaggataaccgaactcaaggcttaattaacggggcactaaacaaaa 2132 NM_014899 RHOBTB3 atattcactcccggaaatgtcgttgcttagtaatgtaacctggagctttt 2133 NM_014914 CENTG2 agctcggctcaaagtgcgaagttgtttagatttccacgttacacaaacac 2134 NM_015050 KIAA0082 gggtatatcagtgtgtcttgcagaatcttggatcattaaagataaacata 2135 NM_015069 ZNF423 acacgatgagccagcacgcacagtgagggatcgctcaacaggacacctct 2136 NM_015099 CAMTA2 acatgatctcactagccaagcagatcatcgaagccacaccggagcggatt 2137 NM_015147 KIAA0582 ccagttttagaggatgtccttgggaggatcgcaaagcagtctggtgagct 2138 NM_015149 RGL1 cagtttctggcaaccccgtgtatttccgttttccccctaaagaacatatc 2139 NM_015158 ANKRD15 acttgaatctcaaagaagtgcggtctatcggttgtggagattgttctgtt 2140 NM_015166 MLC1 acctggggaacgtgttcccggctgagatggattacttgcgctgtgctgca 2141 NM_015196 KIAA0922 aatactacccggggttcaacccgtttcgcgcctatatgaacctggacata 2142 NM_015210 KIAA0802 aggaacttcggcgagaactggaccgcgctaataaaaactgccgaatcctg 2143 NM_015261 KIAA0056 agttcagctgttgacgccttgcagaggctttgtagagcatctgcagagac 2144 NM_015335 THRAP2 gtgtactgccagtgcaggcgaccactgcctacacagatccacattaaatc 2145 NM_015436 RCHY1 ccgactttgacactgttatctccgtaatagctttaccattaggctaggat 2146 NM_015458 MTMR9 aagagtgctgtaaggtacaggtttccatattgtgaacctgtgtacgcaca 2147 NM_015474 SAMHD1 gacagtacttcagtccaaaatccaactcgcctccgagaagcatccaaaag 2148 NM_015528 RNF167 gttgtatccagcaccggaaacggctccagcggaatcgacttaccaaagag 2149 NM_015568 PPP1R16B atatcgtactgaggtaacttccacgtagccccttgccacgcggcaccggt 2150 NM_015570 AUTS2 acaggtcaaccttgtggagccatcgcgagttagagggtgaaagatggcag 2151 NM_015636 EIF2B4 ctggctaactggcagaaccacgcatccctacggttgttgaatctagtcta 2152 NM_015670 SENP3 tcacctattttgactcgcagcgtaccctaaaccgccgctgccctaagcat 2153 NM_015710 GLTSCR2 ttcacttaaccatacggtcagcctagttagagtatgtgattcagtggctt 2154 NM_015833 ADARB1 cacagtctatggaacgctaatggagtcagcccctaaagctgtttgctttt 2155 NM_015855 WIT-1 ggcccatgaaattgatgaactgagagttgcttccagtcctgagcgcacca 2156 NM_015869 PPARG ttgcttaccaaactggacatcattgatgatctggattcaggcagggtctg 2157 NM_015965 GRIM19 atcgcgctgttgccactgttacaggcagaaaccgaccggaggaccttgca 2158 NM_016041 DERL2 aattactggttggtttgtaaacaccatcctccattcgacccattgacttc 2159 NM_016091 EIF3S6IP ttcattccctggtagacaaatccaacatcaaccgacagttggaggtatac 2160 NM_016184 CLECSF6 ttggattggtatctgtcattgtagggatagataataagctcttcttattc 2161 NM_016195 MPHOSPH1 tcaaagcactcgatttccaaaacctgagttagagattcaatttacacctt 2162 NM_016221 DCTN4 ctgctgttaatgatccagcattggtcacaatgtaccaactgctttctgca 2163 NM_016308 UMP-CMPK caacttgtacaaagttgtatgacagggcatattctttgcttccaagattt 2164 NM_016343 CENPF gacaggaaagactagcccatatatcctgcgaagaacaaccatggcaactc 2165 NM_016570 PTX1 aataatttgctgtcgtttcagacttggatcctataaacctgtcaattctg 2166 NM_016734 PAX5 gcctggggtaattggaggatccaaaccaaaggtcgccacacccaaagtgg 2167 NM_017437 CPSF2 ggaaggatcgatcttatttaactatgtgtggaacaacccagtaatatcag 2168 NM_017448 LDHC gttgtaatctagactctgcccgtttccgttacctaattggagaaaagttg 2169 NM_017617 NOTCH1 tcactgtgggcgggtccaccagtttgaatggtcaatgcgagtggctgtcc 2170 NM_017771 PXK atggaactcttctttggggactattactttgcaaatggggtcagagcctc 2171 NM_017787 C10orf26 cattgatcttacgcatttactgtttaccgaacaaatgtctgactgtgtac 2172 NM_017794 KIAA1797 cctaagagaggagtgcattgctttagtacccgggccagttgagactgaaa 2173 NM_018136 ASPM tacagttatcctacaagcactggtgcgtggttggctagtacgaaaaagat 2174 NM_018209 ARFGAP1 tcagccacttgcagaacaggatgggaccgagatttcagcgagccctcctg 2175 NM_018248 FLJ10858 aaattaatatgacagatggccctcgtaccttaaatcctgacagccctcgc 2176 NM_018462 C3orf10 agagtacattgaagctcgggtgacaaaaggtgagacactcacctagaaca 2177 NM_018664 SNFT agcattgttcaaatgagtacactgtcagtggggtttaagatcatttggtg 2178 NM_018951 HOXA10 gtattgctgctgtgcgtggaaaaagacgatgtttatgttcttatagaata 2179 NM_019028 ZDHHC13 cactgccatgtatgcaactgctgtgtggctcgatatgatcaacactgcct 2180 NM_019071 ING3 tgccctatagaatggttccattatggctgcgttggattgacagaggcacc 2181 NM_019102 HOXA5 tcatagttccgtgagcgagcaattcagggactcggcgagcatgcactccg 2182 NM_019111 HLA-DRA aaagatcgtaacgcgagagccatccgccctatgtgggagatcccacaccc 2183 NM_019841 TRPV5 tgattaacatcgctatcactcttgaccttactcccggttggcctgggggc 2184 NM_019846 CCL28 atacggccataaaactccttattagagagtctacagataaatctacagag 2185 NM_019857 CTPS2 aactggccttaggagatccaaatagggaaccaagattgcagagtgtccca 2186 NM_020310 MNT tctagtgccgaatgactatgtccagattggtgacgatgggtgttgctgtt 2187 NM_020368 SAS10 gcaggtcccacgctcaccgacgaaaatggagatgatttaggattgccacc 2188 NM_020371 AVEN cgactcaacgttgctgccgaactggtccagggtacagttcctttagaggt 2189 NM_020631 KIAA0720 tcaccttcgaggcctacaggttcgggggacactaccttcgtgtcaaagcc 2190 NM_020657 ZNF304 tctagaggggacatccacaagtctcggtgcagttatgatggtgtgggatg 2191 NM_020841 OSBPL8 ggtgacccacctcttaggactttggtcttatccacgtgtatgttgttttc 2192 NM_020843 ZNF291 cctcacaaggtgatccttttaacaatcgagttcaggaccttatcagctac 2193 NM_020892 DTX2 acagggcctgatattagtgaaactacactgggatagcatcagccatttaa 2194 NM_020944 GBA2 tgcaggtttatcgggactattacctcacgggtgatcaaaacttcctgaag 2195 NM_020956 PRX cgaaagtgtcaaagattcggctgccggaaatgcaagtgccgaaggttccc 2196 NM_020998 MST1 tggacatgccaatacacattactgacaggtatgcccacctgacctgcacc 2197 NM_021019 MYL6 accagaacagagcacaacaaaggacgagcagcgccagccgagacgacgta 2198 NM_021025 TLX3 ggcgcctgtattatactttgtacttttgcccaaacgtgtaaataataaaa 2199 NM_021038 MBNL1 gtgtaaccatgattctattatgtattggtacgtctgtagaccaagatata 2200 NM_021071 DO gaatggcactctgtgctatgaggtgcattataggacgaaggatgtccact 2201 NM_021103 TMSB10 tccacatcacgactggggtctcgaagaggacgggggtaggaaatcctcca 2202 NM_021111 RECK tacagataattacctactctggctagaagctaggggtcccagtgaagagc 2203 NM_021114 SPINK2 actatactctcccttatcgcgcgtctatatggccccgatcacccttccgc 2204 NM_021603 FXYD2 ccccaggagcttactacaagtgctagaaatctggacaccaggccaaggaa 2205 NM_021643 TRIB2 cagtagagacaagcgggaaggataattagctgaaagctatgatgatataa 2206 NM_021814 ELOVL5 actgctaaaggacaagtttagtcatacactgcataaccatattttggtca 2207 NM_021906 USP9X aacagaacgtacaattcatgcataaccgaatgcagtacagtatggagtat 2208 NM_021949 ATP2B3 tctctgtcgtagacacaccgataggaccaatggccaatagatattaaaag 2209 NM_021960 MCL1 agcaggtggtaataccatgggtgctgtgacactaacagtcattgagaggt 2210 NM_022067 C14orf133 agaacaatgcccctgtgcagatattacaggagtatgtcaatctggtggaa 2211 NM_022127 SLC28A3 tgtggttttgccaatatcgggtccctaggaatcgtgatcggcggactcac 2212 NM_022161 BIRC7 cccttgcttggcgtgggggatggcttaactgtacctgtttggatgcttct 2213 NM_022334 ITGB1BP1 tttgaggtcacgcggctagtaattggagcctggtttagaaccaagtcagt 2214 NM_022366 TFB2M cgttccaaagattgtgcttataaatggctgtatgatgaaaccctggaaga 2215 NM_022436 ABCG5 agatgtccacacgaggggtcggagttacctgatcacatcgagagagtgct 2216 NM_022438 MAL ggatttattaaaaccaagttgtccctaaggaatcagatgtgggcatctct 2217 NM_022469 GREM2 aaacacgagcacactctcttcgaacccaattgtgggtgtagcaatgaaag 2218 NM_022549 FEZ1 cttgctcgctactttctagggtcttaatagtagtcaagaaaagggatctg 2219 NM_022716 PRRX1 ggctaattctaagcactaaagtctacatctaagctatagatttaagcttg 2220 NM_024006 VKORC1 tgctacgtgctcattagtgttcgtccgacgacgaccgtcatatgtccacc 2221 NM_024099 MGC2477 tacaaaaacaaatgagcccgggatagtggcacaggcatgtagttccaact 2222 NM_024319 C1orf35 aggatcagacggaaagcaggggagtttctcgggtcacccttgaagagagg 2223 NM_024408 NOTCH2 ttctttcacaccgtgtggtccgtgttactggtatacccagtatgttctca 2224 NM_024424 WT1 ttgtttcttcttttaccatccttggcacttttagcggggggagaggaggt 2225 NM_024713 C15orf29 cacgtctgtgatttgagaggtgagttatttaagaggccagttttcaggac 2226 NM_024728 C7orf10 actcttcctcataacctcatccaatacactcaaacaacact 2227 NM_025263 PRR3 agcatgatccccaccgctatggtctatctatgatcaccgtgctttgtgaa 2228 NM_030660 ATXN3 tgagatgtacagagagtttcttgctgggtcaataggatagtatcattttg 2229 NM_030674 SLC38A1 acacttgaatcttggtcgttggtatgtaatccactctctagagtccagtg 2230 NM_030915 LBH ttatttttgctggtccctagaccactttgtatgaccgtttgcagtctgag 2231 NM_030926 ITM2C catgtttttactgatcattcgatatgctaaccgttctcagccctgagcct 2232 NM_030935 THG-1 ggaaagctgtagacatgcggctgcggatggagttgggtgctccagaagag 2233 NM_031243 HNRPA2B1 ttcaattgatgggagagtagttgagccaaaacgtgctgtagcaagagagg 2234 NM_031423 CDCA1 aaagaaaagttgaagcgaatggaagtatcagaagtaccaaataatgttgg 2235 NM_031966 CCNB1 ttcctactgtagggtagcggaaaagttgtcttaaaaggtatggtggggat 2236 NM_032121 DKFZp564K142 gtagaaacattttaggccatgtataagttacactgattttagcactaagc 2237 NM_033238 PML ctgttttcagatgtgattgaggggtgttctgccctgcctccactgtcaca 2238 NM_033512 TSPYL5 tattgaaaatccaagacactatgccaatgcaaccgtgactactttgggag 2239 NM_033554 HLA-DPA1 cttagatcccccctcggagtagcggctcacgcaacacaaagtatagcaca 2240 NM_033642 FGF13 ggaaacctggcacgggccaacttttcccgattatcacgccaagaagttgc 2241 NM_057168 WNT16 atactcaggataagatccttgaatatggaacttagttacaggactcaata 2242 NM_058195 CDKN2A atagatacatttcccgtatacttctgcgactatatctctctgtatttcta 2243 NM_080284 ABCA6 cctgtatcacttggttgggggatcctaattcatctaaggtttggccttat 2244 NM_080700 TREX2 cggctttagttacgatgactacagttcccacgtgcgcaactctgcccttg 2245 NM_130439 MXI1 aaacctatagtgcacattttaactgccccctaaattacccttccctgggt 2246 NM_133259 LRPPRC gagctaggtatagtgaccgtgaactttctaacgcataatattctgtgata 2247 NM_133378 TTN acgctccacccaaagccgaactggatgcccgattacacggtgatctggtt 2248 NM_138714 NFAT5 tagtgtacttcttgtctatcctcagttaatttacctagacaaaaagtgtc 2249 NM_144578 C14orf32 attcttaccattaagttaacaatggacgaagagatgacgctttgcttttt 2250 NM_144628 TBC1D20 ccttggcgtcgttttttgggtctgacttgtctcgtcaactgctggtctct 2251 NM_145698 ACBD5 gttcctgctttgtttaataagaacctcatttaaacttgacagctatggta 2252 NM_145867 LTC4S aactttaatgatagagactaggatgcggaagcgagcgcccctccccgggg 2253 NM_147180 PPP3R2 aattttacatggaggaagtgagcacatgtcatgctagccaagaggacatt 2254 NM_152739 HOXA9 atccccgcacaaagcggctctaaacctcaggccacatcttttccaaggca 2255 NM_152788 EB-1 gcttgtgcaaaaatgcgggctaactgtcagaagtctacagagcaaatgaa 2256 NM_152827 SNX3 agaaactggtataacatgccttcagtatactaacactcatatgctcagtt 2257 NM_152890 COL24A1 acacaaacaagtggcccaggattgcctattggtttcaagggatggaatgg 2258 NM_156038 CSF3R gcctcccaggcgatctgcatactttaaggaccagatcatgctccatccag 2259 NM_172020 POM121 catatatagatttctagaactccctctttgcatagtgccctcctttcttt 2260 NM_173156 C1orf16 ctaaaatcagtgctatctacaagccgaaatttaagcaacaactgtgacac 2261 NM_173216 SIAT1 ggtagagaaggatacagtgtctatcctcaagttgctacggttcagtgaga 2262 NM_173609 C15orf21 cactttgaacgccttagaggcaaaaagagctttgtgagttgtaagaggaa 2263 NM_173852 KRTCAP2 agacagatgacgcttttcgattctgcaccttgtatagctcctggagttgg 2264 NM_175739 SERPINA9 gccttccgcctataccgcaggctggttttggagaccccgagtcagaacat 2265 NM_175744 RHOC tccaggtccgcaagaacaagcgtcggaggggctgtcccattctctgagat 2266 NM_178586 PPP2R5C aatgtcactattccaagtgtctttttagtgtggctttagtatggcttcct 2267 NM_181311 TAZ caccagggaaagtgaacatgagttccgaattcctgcgtttcaagtgggga 2268 NM_181336 LEMD2 tcgtcctgacacgattccaaaggtctgccatactcttcagaggagttcgg 2269 NM_181339 IL24 aggaggtgggatatcacttccatgacataagtgctattgcagagccgtgg 2270 NM_181430 FOXK2 caagttcagacgaagctactctggcatctgcacatttccgtgttacagca 2271 NM_181493 ITPA atccttccttcgtctggctcgtgattcacttattcgccctccctactttg 2272 NM_181702 GEM agatgtggtttcccccattgtagcagggagctagcgtattagccttgtgg 2273 NM_182729 TXNRD1 tgtgcagaggtattcacaacattgtctgtgaccaagcgctctggggcaag 2274 NM_182810 ATF4 ggtcccctagttgaggatagtcaggagcgtcaatgtgcttgtacatagag 2275 NM_183395 CIAS1 ggggttcagataatgcacgtgtttcgaatcccactgtgatatgccaggaa 2276 NM_198232 RNASE1 caattatattaaactcggccaaaccctctgcgggataaaggggttttgtt 2277 NM_198400 NEDD4 tcagtgcatttcacccaacgaaaagcagctacattagactgtgaaacaac 2278 NM_199335 FYB ggtctgtccagctttcacacattgatatgtgaggctacatttgcatgtta 2279 NM_199423 WWP2 gccggccagttaattcattctcagccaatgaaggtttgtctaagctgcct 2280 NM_201592 GPM6A taattttacaagttcttgtagtaggtagggggtactactagggatatctg 2281 NM_201632 TCF7 tctactccgccttcaatctgctcatgcattacccacccccctcgggagca 2282 NM_201998 SF1 cttttttcggtgttagattcaacactgcgctaaagcggggatgttccatt 2283 NM_212474 FN1 gtcaacgaaggcttgaaccaacctacggatgactcgtgctttgaccccta 2284 R14777 CYFIP2 agcagcgtcgctttgacctgttcgacttctgttaccacctgctaaaagtg 2285 R56397 PIK3C3 gtgagcagtaccaagagttccgtaaacagtgttacacggctttcctccac 2286 R59027 GRP58 ctctttttgtggatttgatgaccttatggatattgccaaagtttaaggca 2287 R72151 GNL3 ctgttctctgtataagttatggtatgcatgagctgtgtaaattttgtgaa 2288 R79128 MAP3K1 ctctgtatgtaacaatccatcattcaccttcactactggtagtaacatag 2289 R86893 C6orf110 cccgtgttacaacgtggctcgcctaatgttcctcgatgcagagaggaaga 2290 T07281 NRIP1 gactaataaaagtacaaggcacatatacgtgacagaattggtactcaatc 2291 T28925 ITGAL cgtacttagcagctatctctcagtgaactgtgagggtaaaggctatactt 2292 U60115 FHL1 atgtaatgacaatacatactaacattcttgtaggagtggttagagaagct 2293 U79271 AKT3 tctggtttagacttaatatgccacaacgcaccacgaccttcccagggtga 2294 W04885 MYL4 atcttcttgtcgtgaccccgatcacaaataacaaatgctcttaacactct 2295 X66087 MYBL1 ctggatatacatagtctgcaatcaccaaagtataatatcttgtaaggcta 2296 AK024272 gaggttgcgacaagctactccaatacccctgctgggatagtgtcacagaa 2297 AK025231 IGLC2 caaagctgaaaccaaatctttataacaagggtggttaggtcagcattctt 2298 AL080190 ccatgcttgaaaatgtctgaatggcagtaatgaggataagttttttaatc 2299 BU618233 actcctattattcatcgcaagactcttctatagtaatccagttcaagata

TABLE 22 60mer polynucleotide probes, according to one embodiment GenBank SEQ Accession No. ID for Target NO: gene Symbol 60mers 2300 AA594161 MYH11 aactgcggctggaagtcaacatgcaggcgctcaagggccagttcgaaagggatctccaag 2301 AA766908 MME acagagcagtaccagcgctctaaaagcacctccttgtcactttattactccagaacaac 2302 AB014540 SWAP70 ggctaagatagatacttgtgaatcaaagatagcacagaaatgaactaagtatatcccatt 2303 AF196185 PARD3 gtttcttaatcacgtgcggcggtgtctaagtggtgttaccagtgtacgcgcagtgacctt 2304 AI597616 MRPL33 taagctcattcttagtcgtagatagcttgggaatctcatatgcagagtatccatattgac 2305 AI634809 ARID5B ttctcttaccatccgatattaagttgggcatgatccaactagtatcactaccttttgaag 2306 AI672553 AKAP12 ctgcattcacacatggcatgaaataagtcaggttctttacaaatggtattttgatagata 2307 AI809213 RGS13 aggacagtatatgagatttctatcgtacagggcaagcctacattgtggacatattctaga 2308 AK022231 STAT1 tcgcactctgtgtatataacctcgacagtcttggcacctaacgtgctgtgcgtagctgct 2309 AK022293 CTSD gccagtaaaggcacccctagctcttgggatgtttgtatccaactccgggcaatgtggggc 2310 AK055652 C3orf6 ataatttagaaacgtgatctcttgagagagagactacgcattgcctgggcactttcagat 2311 AL080130 FLJ14001 gtgagaataaatttagctgcataaaacgttcggctcatttatctgacatcttagtcacat 2312 AL833316 MIR gccctcagtctttttgggccttaggcgtttcgttcatcctgctaaggggatgaagcaaac 2313 AW291384 STS-1 ggctgaagatacccgcttaaggatgctaacatttaccctggtactgccacattttctcta 2314 BG993697 SMYD3 tttcttgaaaacctcctgtagttcctgttgtgtacgggataaaggtgcttaccatggggc 2315 BI769730 HLA-DRB1 cactatcgccgaaatatgcacaatcgcggtgtacgaggagcatacgccacacttatgatt 2316 BQ632574 RASA1 cctccaactaaccagtggtatcacggaaaacttgacagaacgatagcagaagaacgcctc 2317 BX504817 SFRS7 tactggtctgcatcaagtttattcggtagtttgaccgctagtatgttggaagttatttgg 2318 H53164 IRF8 cagcctgagtcagcaccaatcccgcattcagaacctcccagtgaaagggcagccttcatt 2319 H57732 TGFBR2 tttttatatttttcgtcacgttccccctgtagcctggaaagggacggtaacaattaaaga 2320 L29376 3.8-1 tgtttaaccttatatgtacagtttcacatatgtataaaaacagtagtttgggggcctctt 2321 M80899 AHNAK tgcaaagttgaaaggccctaaatttaagatgccagacatgcacttcaaggcccccaagat 2322 NM_000038 APC ttgccagctccgttcagagtgaaccatgcagtggaatggtaagtggcattataagcccca 2323 NM_000043 FAS accggggcttttcgtgagctcgtctctgatctcgcgcaagagtgacacacaggtgttcaa 2324 NM_000061 BTK tgggggtggaccgaatttggcaagaatgaaatggtgtcataaagatgggaggggagggtg 2325 NM_000075 CDK4 aaatatcagacgtcatattacacatagtatccgccccaaaaccgatgaacacacccagca 2326 NM_000109 DMD gaacatgcattcaacatcgccagatatcaattaggcatagagaaactactcgatcctgaa 2327 NM_000189 HK2 atttcaccaagcgtggactactcttccgaggccgcatctcagagcggctcaagacaaggg 2328 NM_000237 LPL agagagatgatcgtgcctataaatagtaggaccaatgttgtgattaacatcatcaggctt 2329 NM_000269 NME1 cgactaccaccgaacaccttccccgatgtgatcctcaactaaccgacaaaatatacacgg 2330 NM_000271 NPC1 tgactgaactgtgtctaagggtcggtcggtttaccactggacgggtgctgcatcggcaag 2331 NM_000295 SERPINA1 ggttgagtcataccaaatagtgatttcgatagttcaaaatggtgaaattagcaattctac 2332 NM_000313 PROS1 tcaaactgggttattcactgctgcacgtcagtcaactaatgcttatcctgacctaagaag 2333 NM_000397 CYBB attgacatctgagcatactccagtttactaatacagcagggtaactgggccagatgttct 2334 NM_000405 GM2A ccgctttaaggtccataaatatccctaaggaaaaatccaccgtggtacattcagtcctct 2335 NM_000424 KRT5 aagccatgttttatccttttctggagagtagtctagaccaagccaattgcagaaccacat 2336 NM_000483 APOC2 cctgcccgctgtagatgagaaactcagggacttgtacagcaaaagcacagcagccatgag 2337 NM_000576 IL1B gtagcagtgtctgtaaaagagcctagtttttaatagctatggaatcaattcaatttggac 2338 NM_000579 CCR5 aatgtctttccttttgctcttaagttgtggagagtgcaacagtagcataggaccctaccc 2339 NM_000584 IL8 gagttagaactattaaaacagccaaaactccacagtcaatattagtaatttcttgctggt 2340 NM_000585 IL15 agtgatgttgtcttatagtctctatattctattcagtctcggcttgtcttttctagtggt 2341 NM_000600 IL6 actggcagaaaacaacctgaaccttccaaagatggctgaaaaagatggatgcttccaatc 2342 NM_000626 CD79B atgaggacatagtgacgctgcggacaggggaagtgaagtggtctgtaggtgagcacccacg 2343 NM_000627 LTBP1 aatctgtcctggtggaatgggttatacggtttctggcgttcatagacgcaggccaatcca 2344 NM_000633 BCL2 gatattctgcaacactgtacacataaaaaatacggtaaggatactttacatggttaaggt 2345 NM_000655 SELL tatttgcactgtagcctcgccgtctgtgaattggaccatcctatttaactggcttagcc 2346 NM_000713 BLVRB cggataacagcgacaatcgaacgctgaccgcttagaccttcgtgagtagctcggtgtcgt 2347 NM_000785 CYP27B1 ccctaggaaggtgaatctgccctagcctggtttacggtttcttataactctcctttgctc 2348 NM_000788 DCK ctctcacttcgttggtgaccagtttcttaaactgaaagctttaatgttacatagtaaatg 2349 NM_000853 GSTT1 gaagcagaatccaggtatggctggtggggcaagtaaggcgactctacttggctaagcctt 2350 NM_000877 IL1R1 agaatcgattaaattcattaagcagaaacatggggctatccgctggtcaggggactttac 2351 NM_000917 P4HA1 cagacgaatgtcagcgtcacataaaaagagcatgtaggatgggacatattgggatgtatt 2352 NM_000927 ABCB1 agcggctccgatacatggttttccgatccatgctcagacaggatgtgagttggtttgatg 2353 NM_001067 TOP2A cttgcttcaaacggaatgacaagcgagaagtaaaggttgcccaattagctggatcagtgg 2354 NM_001068 TOP2B ccaacaccaactgcaaagtcgactcagagatgtagtctagccatgtgctcaggtacagac 2355 NM_001110 ADAM10 gtacactgtacttctgtgtgcaattgtaaacagaaattgcaatatggatgtttctttgta 2356 NM_001154 ANXA5 ttggtcatgagcatgctagtatgaataaggcaatgtgttaagcactggcatacaaatgca 2357 NM_001166 BIRC2 tggagttcatcagagttatggtgccgaattgtctttggtgcttttcacttgtgttttaaa 2358 NM_001196 BID tcttgctttcctcaaacaggatactgcctgctgtaagaccatcctctatggttgtacttt 2359 NM_001230 CASP10 cctggaactgtattttgaatccttaaaggtgagccctcatagggagatccaaagtcctgt 2360 NM_001238 CCNE1 tgaatttccttatggtatacttgctgcttcggccttgtatcatttctcgtcatctgaatt 2361 NM_001242 TNFRSF7 caggcaaggcacctgaattcccaccgcagagagtgttgtggccgtgaggacttttctgtc 2362 NM_001254 CDC6 cattgtggcattttagactcgttgagtttcttgggcactcccaagggcgttggggtcata 2363 NM_001350 DAXX agaatgttctgggataacatttggaggaaggtgggaagcagatgactgaggaagggatgg 2364 NM_001425 EMP3 gttatagatcttgttcccccccgcacctttcccgccgcgttttggcttcttccctctgtt 2365 NM_001552 IGFBP4 ggcatcttctggcttgactggatggaaggagacttaggaacctaccagttggccatgatg 2366 NM_001558 IL10RA cagaataatgactgacttgtctaattcgtagggatgtgaggttctgctgaggaaatgggt 2367 NM_001618 PARP1 tgggtagtacctgtactaaaccacctcagaaaggattttacagaaacgtgttaaaggttt 2368 NM_001621 AHR ccaagcggcatagagaccgacttaatacagagttggaccgtttggctagcctgctgcctt 2369 NM_001663 ARF6 gaacaataaccattggtgactggagcaggtaattatagcctgcagaaaaaattatctaag 2370 NM_001706 BCL6 tttgggaatgtttgtctcatcccattctgcgtcatgcttgtgttataactactccggaga 2371 NM_001760 CCND3 agggaggcaagccctgttgacacaggtctttcctaaggctgcaaggtttaggctggtggc 2372 NM_001762 CCT6A agaggtaaaaagatgatggaaggtgtggtgactaagggccacggttattgggtgaaattt 2373 NM_001770 CD19 cccaagattcacacctgactctgaaatctgaagacctcgagcagatgatgccaacctctg 2374 NM_001771 CD22 tctcctttggaagtgaggcattgcacggggagacgtacgtatcagcggccccttgactct 2375 NM_001779 CD58 gcattagttttggctgtcatcaacttattatatgactaggtgcttgctttttttgtcagt 2376 NM_001781 CD69 gcaatatgtgatgtggcaaatctctattaggaaatattctgtaatcttcagacctagaat 2377 NM_001782 CD72 aaggattggaagttgactgatgatacacaacgcactaggacttatgctcaaagctcaaaa 2378 NM_001826 CKS1B caaaccgagcgatcatgtcgcacaaacaaatttactattcggacaaatacgacgacgagg 2379 NM_001827 CKS2 atcgcgcgaccagctaaacactcctgcggtcgtatggtcgacaacaatcacacataaaat 2380 NM_001831 CLU gtcagtgtgattcacttaatgatatacattaattagaattatggggtcagaggtatttgc 2381 NM_001852 COL9A2 tgaaggaatagggcggctttccttccagcgagcatcattcggctgttaccaaaacaaaca 2382 NM_001853 COL9A3 ataaaaggttgtgtacaactccacgaggtgaaaaatattcagtaacttgtttacatagca 2383 NM_001877 CR2 cattactgtatatactttgccttccataatcactcagtgattgcaatttgcacaagtttt 2384 NM_001888 CRYM gagatcctcatttatgtttgtagttggaaagcaaagctaggtagccatttcttctgttct 2385 NM_001894 CSNK1E gctatccctccgaattctcaacatacctcaacttctgccgctccctgcggtttgacgaca 2386 NM_001951 E2F5 ttgacttctgacattccactttcctaggttataggaaagatctgtttatgtagtttgttt 2387 NM_001967 EIF4A2 ggactctttacctcgcggcggaagaatatagctgcggagttagttaaacctcgctttccc 2388 NM_002002 FCER2 ccagcggctttgtgtgcaacacgtgccctgaaaagtggatcaatttccaacggaagtgct 2389 NM_002051 GATA3 ttttaacatcgacggtcaaggcaaccacgtcccgccctactacggaaactcggtcagggc 2390 NM_002095 GTF2E2 tttcttcctcgtttgttactttagagcaagtttgcccatagtcttgaatgcaatatttgt 2391 NM_002101 GYPC catcttccagtaactgagcatacccagtgggccaacaagcacgctctaaatacaaaacca 2392 NM_002105 H2AFX ttggtcacgatccccgcctacccaccaatccttaacgcgcctcaccggaccttaacattc 2393 NM_002120 HLA-DOB cctgggtgaggtaaaggacattcatgaggtcaatgttctgggaataactctcttccctga 2394 NM_002122 HLA-DQA1 cctggggtaagccacccggctacctaattcctcagtaacctccatctaaaatctccaagg 2395 NM_002155 HSPA6 gctgtgactgtcagggctatgctatgggccttctagactgtcttctatgatcctgccctt 2396 NM_002189 IL15RA aggtgggagagatgctgagcccagcgaatcctctccattgaaggattcaggaagaagaaa 2397 NM_002211 ITGB1 ccatcttgtttcacactagtcacattcttgttttaagtgcctttagttttaacagttcac 2398 NM_002217 ITIH3 gtgtccacactgactacattgtccccaacctgttttgagtagacacaccagctcctgttg 2399 NM_002250 KCNN4 ggaagaagtgtaactcaccagcctctgctcttatctttgtaataaatgttaaagccagaa 2400 NM_002305 LGALS1 atcaactacatggcggcggatggagacttcaagattaagtgcgtggcctttgagtgaagc 2401 NM_002350 LYN tccaaaaatgcacccaactagctctatgtttacaaatggacataggactcaaagtttcag 2402 NM_002358 MAD2L1 catgttcgtgccagaacatgttacaccactcctacgatggcttgcccgattcgatgcccc 2403 NM_002426 MMP12 ttaagtttgaaaatagttaccttcaaaggccaagagaattctatttgaagcatgctctgt 2404 NM_002467 MYC gccataatgtaaactgcctcaaattggactttgggcataaaagaacttttttatgcttac 2405 NM_002526 NT5E tctgaacagtcactgtaaatcattcttaagcccagatatgagaacttctgctggaaagtg 2406 NM_002567 PBP agggcatttcaaatgacgagaagagctagtaatcacctgcacaaagggcgatggtggcgt 2407 NM_002646 PIK3C2B tatgcctcccgctatggcaaccgaaagaatgcgacgcctggcaagaaccgccggatttct 2408 NM_002661 PLCG2 gtgccctattcacactctgggaagacgctaatctgtgacatcttttcttcaagcctgcca 2409 NM_002692 POLE2 gcctttggatttccacccactgagccctctagtactactagggcatactatggaaatatt 2410 NM_002738 PRKCB1 agagagatccttaacagctagtgcccattagggggctaaacctaaagcctgggtggtgat 2411 NM_002752 MAPK9 atctctgtagacgaagctctgcgtcacccatacatcactgtttggtatgaccccgccgaa 2412 NM_002832 PTPN7 gcttccatggctcaaataataccctgggtatgcaggacccactataccttgcatttgctg 2413 NM_002838 PTPRC gacattcttccttatgattataaccgtgttgaactctctgagataaacggagatgcaggg 2414 NM_002891 RASGRF1 ggcacgcgcaaaggctacctgagcaagcggagttcggacaacacaaaatggcaaacc aag 2415 NM_002892 ARID4A aagttttatatttggtacattactatggatggaatgtcaggtatgatgagtgggtgaagg 2416 NM_002943 RORA ctctagggagacctaataaacacaactgtgttactaattgatgctatactgagctgacaa 2417 NM_002966 S100A10 ctcataccaactatcggcaagaacgcaccgtttccgcacttcatttttaccccgcgcttc 2418 NM_002967 SAFB aatgtgccgtgggttccacgccgtgtgcgcaagttccctgtgtgaaagcacgtctgtctt 2419 NM_003037 SLAMF1 caagctacggaacaggtgggcgcatgatgaactgcccaaagattctccggcagttgggaa 2420 NM_003088 FSCN1 ttgacatcgagtggcgtgaccggcgcatcacactgagggcgtccaatggcaagtttgtga 2421 NM_003177 SYK attgcagagtggcctagagcactctcaccccaagcggccttttccaaatgcccaaggatg 2422 NM_003217 TEGT tactaaaggcacttccttcctgttaaacccctgttaactctccataaatttggtgattct 2423 NM_003226 TFF3 ttcgcctgaccatccacttattctgccacccctgcatggtccccactgcacttaacaggg 2424 NM_003243 TGFBR3 ctgctttgtccaggtgagaacatccataatttggggccctgagttttacccagactcaag 2425 NM_003254 TIMP1 ggaaccctttatacatcttggtcatcttgatctcataacgctggtataaggtggtctggt 2426 NM_003290 TPM4 ggattaaggcccttatgagaagaggccagaacttggttatcctcttccaatgtgaggaca 2427 NM_003299 TRA1 cttgttttggatgccccctaatccccttctcccctgcactgtaaaatgtgggattatggg 2428 NM_003332 TYROBP gtgccatccctgagagaccagaccgctccccaatactctcctaaaataaacatgaagcac 2429 NM_003362 UNG gctgggagcagttcactgatgcagttgtgtcctggctaaatcagaactcgaatggccttg 2430 NM_003451 ZNF177 ctaaatgaaacaacaggggagatacaatattatctggttgcactaatcctgtgctgctta 2431 NM_003648 DGKD tgatgctggatcttgccaagcgcagtcgcagtggtaaattccgcctcgtgaccaagttta 2432 NM_003656 CAMK1 actcacagctgcatgatgaggtagaggtggcccccactctcatagatgtcatccagggct 2433 NM_003810 TNFSF10 tccttaagtcaaaagagagaagaggcaccactaaaagatcgcagtttgcctggtgcagtg 2434 NM_003875 GMPS ctgtggttattcgaacctttattactagtgacttcatgactggtatacctgcaacacctg 2435 NM_003959 HIP1R tttgcccgtcagatttgaacgaatgtgtgtcccttgagcccaaggagagcggcaggaggg 2436 NM_004049 BCL2A1 cctataaggagatttcatattttgttgcggagttcataatgaataacacaggagaatgga 2437 NM_004073 PLK3 cgaatgggttggcttctccaataagttcggctttgggtatcaactgtccagccgccgtgt 2438 NM_004091 E2F2 tttatgagcaccatgtaagcctccttgtattgagataattgggcattaaacattaaactg 2439 NM_004117 FKBP5 gtggttctgagcaaataactacagggtgcccattaccactcaagaagacacttcacgtat 2440 NM_004126 GNG11 cggcagcaatatcacccaagagccataatacacctattataagcgaccagcataataaag 2441 NM_004184 WARS cccctcccaaaaagaaattgataagtaaaagcttcgttatacatttgactaagaaatcac 2442 NM_004271 LY86 gaagcggcaatcagcccgcgcgtggaaccgagacaagtaaacaagacgccagatctct ga 2443 NM_004289 NFE2L3 tggcagccatcctttttaagagtaagttggttacttcaaaaagagcaaacactggggatc 2444 NM_004322 BAD gaggccctgtgcctagcacaaaataagggcataagaaatactagttacatcacaaggtca 2445 NM_004354 CCNG2 ggttgttaaacagtaatagataagtgagacagattgcttgttatttatggtcaaatggtg 2446 NM_004356 CD81 ctttctaacacgtcgccttcaactgtaatcacaacatcctgactccgtcatttaataaag 2447 NM_004358 CDC25B cccactcggtcccagttttgttgccccagaaagggatgttattatccttgggggctccca 2448 NM_004422 DVL2 tcagcctaccagctgctgccatacaggagattgtggccactgtgactctcaccagcagtg 2449 NM_004445 EPHB6 tgcccgggaagtcgatcctgcttatatcaagattgaggaggtcattgggacaggctcttt 2450 NM_004510 SP110 tcccatctttagaagcaatctaccatagttcaccctctggccacagtagttcacatcttt 2451 NM_004529 MLLT3 tattccatcttctccataagtggagaaatgaaaagtaagaacagctcatcttcaaagttt 2452 NM_004556 NFKBIE cttgttttacccatgttgggtcagcctgaaactgccaaccagtaggaagcatggactctc 2453 NM_004577 PSPH agctagccaaaatctgtggcgttgaggacgcggtgtcagaaatgacacggcgagccatgg 2454 NM_004619 TRAF5 gagcaagactgtccttttaagcactatggctgtgctgtaacggataaacggaggaacctg 2455 NM_004635 MAPKAPK3 cttgctgcatttgatcctctacaactggtgttgctcccgttatgcggacagaagacagcc 2456 NM_004737 LARGE tggagaaatgcgagacaatccacgttgctattgtctgcgctggatacaatgccagccggg 2457 NM_004844 SH3BP5 ctttgctatcattctagggctggatttccctaactccagttattctgctgctgccgccat 2458 NM_004951 EBI2 aatgggctttgactggagaatcggagatgccttgtgtaggataactgcgctagtgtttta 2459 NM_005013 NUCB2 gctaatcaaagcggcaacaagtgatctggaacactatgacaagactcgtcatgaagaatt 2460 NM_005077 TLE1 cagaggggccatgggttgtaggattgaggaacggaatctgccgactcacatgacagccca 2461 NM_005127 CLECSF2 tgctatttatactttgagttactcttcaaaagtggtatacctctagtttggagctgtgct 2462 NM_005211 CSF1R actcccccaagctgactcatcctaactaacagtcacgccgtgggatgtctctgtccacat 2463 NM_005213 CSTA gcgggtttggcctcagataagcctccaggtatcattttggctgattgcttctttgctgga 2464 NM_005214 CTLA4 agccaggtgactgaagtctgtgcggcaacctacatgatggggaatgagttgaccttccta 2465 NM_005271 GLUD1 gggccttttgaacagtagtgtccccatgaagtgctagataatatatgtgtaagagtcagc 2466 NM_005292 GPR18 tcaggctcgagtcattagtgtcatgctataccgtaattaccttcgaagcatgcgcagaaa 2467 NM_005347 HSPA5 ccttacctcaaaggctctcactaccgtggaccacctagtctgtaactctttctgaggagc 2468 NM_005348 HSPCA ccctgtagttgacaattctgcatgtactagtcctctagaaataggttaaactgaagcaac 2469 NM_005415 SLC20A1 ttcgggcaagttaaatgggacagccttccatgttcatttgtctacctcttaactgaataa 2470 NM_005449 TOSO cagccccctgtagttgacaggtaagctgtaggcatgtagagcaattgtcccaatgccact 2471 NM_005461 MAFB gtgcactggtaagcagacactgcactgaaccaactgctatgctcagaatgtaccagaaac 2472 NM_005531 IFI16 tgaaactcacctgctttgaattggcaccgaaaagtgggaataccggggagttgagatctg 2473 NM_005582 LY64 gcgacagcattgattctcttagccatcttaagggaatctacctcaatctggctgccaaca 2474 NM_005601 NKG7 ctcgtccactcccccgctatccaacgtcacatctaagcactatgacatgcaccgaccgaa 2475 NM_005606 LGMN actgcttcaactggcactcccccacgtacgagtatgcgttgagacatttgtacgtgctgg 2476 NM_005610 RBBP4 ccattgctctgcatctctagcccactttatatcctgccaccagtacttcttgtaatccca 2477 NM_005623 CCL8 ctgtctgtagtgttgtggggtcctcccatggatcatcaaggtgaaacactttggtattct 2478 NM_005638 SYBL1 ctgaataaaattgatgtgcatgttttagggatcaattacctaactgttccttggtctatt 2479 NM_005652 TERF2 tatgtaggcaggttaatcctccacttctcatgtggttgaaccagtgtgttttttggtaaa 2480 NM_005658 TRAF1 taacctcttgatccctactcaccgagtgttgagcccaaggggggatttgtagaacaagcc 2481 NM_005856 RAMP3 agacgaggttctcatcccgctgatcgttatacccgtcgttctgactgtcgccatggctgg 2482 NM_005935 MLLT2 tgtagtcatatctgagcataagaccttgatgtgtgattcctgatgaccggtttcatttat 2483 NM_005950 MT1G aatacaaagatctcggattatccatcacctcttgtacaattacaccccaagtccctcgtc 2484 NM_006006 ZBTB16 ttgcggctgagaatgcacttactggctcattcagcgggtgccaaagcctttgtctgtgat 2485 NM_006014 DXS9879E tacaacacaacaccagcgcccaatatacgcgaatgaggcgccctatacccgcctctccac 2486 NM_006115 PRAME tgtcctgagtctaagtggggtcatgctgaccgatgtaagtcccgagcccctccaagctct 2487 NM_006162 NFATC1 gtacaattagttgcttattacgtatgattactcacagcgatctattgttccatataacca 2488 NM_006164 NFE2L2 atcctcatttataaacctggggtttgaactgcggtctccacgatcactgtcagctctcct 2489 NM_006195 PBX3 acagctttattacctcatgcgaactcatacaaaccaatagaatttcaacatgttctgtag 2490 NM_006218 PIK3CA ggggatgatttacggcaagatatgctaacacttcaaattattcgtattatggaaaatatc 2491 NM_006254 PRKCD gccttcggagggaaattgtaaatcctgtgtttcattacttgaatgtagttatctattgaa 2492 NM_006257 PRKCQ ctcagccgcagacaagtaatcactaacccgttttattctattcctatctgtggatgtgta 2493 NM_006317 BASP1 ttagcctacctagatttctcatgacgagttaatgcatgtccgtggttgggtgcacctgta 2494 NM_006332 IFI30 aagaagtccaatgcaccgcttgtcaatgtgaccctctactatgaagcactgtgcggtggc 2495 NM_006475 POSTN atactggaaaccatcggaggcaaacagctcagagtcttcgtatatcgtacagctgtctgc 2496 NM_006498 LGALS2 gccacgagggaactggcttacgctgttggcacatttccttccagacggttctccacagat 2497 NM_006558 KHDRBS3 aagcttccatcagccaccgaatgcttaagaactcatctaagccagtcctctcattgattg 2498 NM_006620 HBS1L acactaccaaactgtcagtgaacccgccgttattaaacgattgattagtgtcttaaacaa 2499 NM_006644 HSPH1 gtcatgaatgctcaggctaaaaagagtcttgatcaggatccagttgtacgtgctcaggaa 2500 NM_006734 HIVEP2 tcgatgagaatatgacccaaaggacactggtcaccaacgcagccatgcaagggataggat 2501 NM_006763 BTG2 aaacaggtccctgcctttttagaagcagcctcatggtctcatgcttaatcttgtctctct 2502 NM_006841 SLC38A3 ttcagctggctgcggcatgtgcttattgccgttggcctgctcacttgtatcaacctgctg 2503 NM_006889 CD86 actcctagcacctggctagtttctaacatgttttgtgcagcacagtttttaataaatgct 2504 NM_006892 DNMT3B ggaaccgtgaagcacgaggggaatatcaaatacgtgaacgacgtgaggaacatcacaa ag 2505 NM_006986 MAGED1 ttatgttcacagatattgctatcaatcgcagtagtctttcccctgtgtgaggctgaagcc 2506 NM_007311 BZRP tgtctagcgggctcctcacactcaacatgtcctaaatgctgggtatcgcatgaagcactg 2507 NM_007360 KLRK1 acaggttcacagttaagaaggaattttgcctctgaataaatagaatcttgagtctcatgc 2508 NM_007361 NID2 ggccagtttactgatgagtatctcccagaacaacgatctcacctctacgggataactgca 2509 NM_012203 GRHPR tatatgtacttgtcacattggtgttggacacatttgcgccaaaagtatggtaattctatt 2510 NM_012448 STAT5B tccagcaaccctggttggggggtcagacttgatacactttcaggttgggagtggacccac 2511 NM_012452 TNFRSF13B catcagcccatctccagcgctgtcccaattacagccctagcaagtggagacaacaagaag 2512 NM_013230 CD24 aaaaatagacactccccgaagtcttttgttcgcatggtcacacactgatgcttagatgtt 2513 NM_014246 CELSR1 ataaaaaactctagtccctttaaacgtttgcccctggcgtttcctaagtacgaaaaggtt 2514 NM_014257 CD209L gaaatgagaacacggggtaactgcgatcattgcacttggtgttcacagtgggccaggcac 2515 NM_014338 PISD tgcaggagagacatcattgaattttttcaactgtatcagtagcacagtatttttgtatga 2516 NM_014456 PDCD4 catgtttattatctaatcattccaagttttgcattgatgtctgactgccactcctttctt 2517 NM_014686 KIAA0355 tgtgagactgtgtgaagccgtttgtgtggtctccatgtaggtgctgtgttcccggcaccg 2518 NM_014762 DHCR24 gatgaatggttaacacgagctagttaaacagtgccattgttttgccagtgaagcctccaa 2519 NM_015187 KIAA0746 agtggtttcgactggatatctcttttaacggaggccagatagtagtaaccactagcattg 2520 NM_015641 TES agccacccatttgcttttaatccaaagaacatgtatagtttttgtacccagagactatga 2521 NM_015866 PRDM2 taatgatgcgcttttgtcccgtaaatgttaacactcatgaagcataccccggcctctcag 2522 NM_016076 PNAS-4 agggaattctggttttagtccattggtagcattgtgtgtatgaggagattcaacaccaca 2523 NM_016081 KIAA0992 cagtcgctatgcagcactttcggaccagggactagacatcaaagcagcgttccaacctga 2524 NM_016187 BIN2 atagacacagacacttgcctatacagagacataaccacacacactcagaggatagtgaac 2525 NM_016336 UBE2J1 tcatcaacctacccaacctgtagctaagaatacctccatgagccctcgacagcgccgggc 2526 NM_016628 WAC aactggtatatgtcaggctttcccaatagcttaactgtgaccctatacggatggcttttt 2527 NM_017530 LOC55565 gtcattgggtcgccacctcttaatccactcggaggaccagcgatctaactgtgctgtgtg 2528 NM_017784 OSBPL10 ctactgtgagtgcgaggagaagagactgtgcgtcaacactcatgtatggaccaaaagcaa 2529 NM_017935 BANK1 ttctgaatttctcacattcagagttccagtcattattgttacatcatgtttgcagaaacc 2530 NM_017955 CDCA4 atctgaatccatgtcattcataaccccttgatctgtagtgtcatgggtgctgccgcaggc 2531 NM_018442 IQWD1 tattttaattaactgtcgacgtgctgccacgtctgttgctatttgcccaccaataccata 2532 NM_018842 BAIAP2L1 tcatgcttctctgtttcacgtagttgggttgacaagtttctgcctttaagataaatgagt 2533 NM_020151 STARD7 atgcacaagtgcgaaggagttgcggttgctccatgttctgacttagggcaatttgattct 2534 NM_020199 C5orf15 ggtcttggcgctcctgcttgtgtccgccgctctatccagtgttgtatcacggactgattc 2535 NM_020529 NFKBIA atgaacggtccatgccgataagtaaacgtcgaacaattgcccttcaaccactccctctaa 2536 NM_020992 PDLIM1 gtcccagagccaggttgtgaaggttttccttcactgcggagcccttaggttatgaacatg 2537 NM_021813 BACH2 agaaaagtctcattgtggcagattgagcataaattattcaactgacggtgcaaaaacatt 2538 NM_021822 APOBEC3G agtttcaaacctactaatccagcgacaatttgaatcggttttgtaggtagaggaataaaa 2539 NM_021950 MS4A1 cttagagttaccacaccccatgagggaagctctaaatagccaacacccatctgttttttg 2540 NM_021966 TCL1A tgcctgtagcccactctgctcgccttagcactaccactcctgcccaggaggattccattt 2541 NM_022552 DNMT3A aaccacagaggcggaaataccggagggctttgccttgcgaaaagggttggacatcatctc 2542 NM_023037 13CDNA73 tgcttgagcaccagacaagcttggtatcttctgaggacggtgcccgagagcaggagaaca 2543 NM_024708 ASB7 aggtaccacaccgcttcagctcgccattatccgagagaggtcaagctgtgtgaaaatcct 2544 NM_025113 C13orf18 tgtggaactccagtagagcctagtaagtacggataatggatcgcctgcttatgatgtgat 2545 NM_025216 WNT10A tgtgagtaagcgagacacaacacttgtcctcttggaggttacattcttgctggggggagg 2546 NM_030666 SERPINB1 agagttacactctcaactccgacctcgcccgcctaggtgtgcaggatctctttaacagta 2547 NM_030764 SPAP1 tggtgtggaaaattacctggtgttgtagcgaagtagccatttccattctaacccagtcct 2548 NM_030775 WNT5B aagtccaaggtcatctctggcccagtgaccacagagagatctgcacctcccggacttcag 2549 NM_031305 ARHGAP24 ttcatatcttttcacctatttccagtccttatcatagttgataaaaacctcagactcatc 2550 NM_031942 CDCA7 taggtaattattgcagattgatgtctctcaatcccatgtattgcgcttatgttacaagtt 2551 NM_032991 CASP3 acgggagatttcttgttgctcaaaaaatgagctcgcatttgtcaatgacagtttcttttt 2552 NM_033208 TIGD7 catattgtccgttttccggtattgagttagggaaagtatgcaggtattcctgtcattcct 2553 NM_033274 ADAM19 agatcgccaactatgttgataagttttaccgatccttgaacatccggattgctctcgtgg 2554 NM_057735 CCNE2 gctttcttgacatgtaggttgcttggtaataacctttttgtatatcacaatttgggtgaa 2555 NM_078467 CDKN1A accctgtactgttctgtgtctttcacagctcctcccacaatgctgaatatacagcaggtg 2556 NM_079421 CDKN2D gttggaagcttgttttccagtctcttgtacagcgttttaaaagaaatggattctatttat 2557 NM_080593 HIST1H2BK gtgtgggccgtaaaaggaagggcaaaagctacactttagaatgcacgaggtccatctttc 2558 NM_138340 ABHD3 caattgatgattattatactgatgccagtccgagtcctagactgaagtcagtaggaattc 2559 NM_138379 TIMD4 cccaaaaaagaggccggagtgagagggagtgactattaacggcgggcgaaacgaaaa taa 2560 NM_139207 NAP1L1 tcctttctgagaagttagtgttaaggtcttggaatgtgaacacattgtttgtagtgctat 2561 NM_139276 STAT3 taatccctgaaacgggcttcaggtcaaacccttaagacatctgaagctgcaacctggcct 2562 NM_144646 IGJ atgcctgctatcctgactaatttaagtcattgctgactgcatagctctttttcttgagag 2563 NM_145804 ABTB2 ctagagctgtttgttcaatcactgatgggcaaaggggagatgtagctaactggtggccct 2564 NM_152785 GCET2 tagtactcttcagcagagttccctgatggccttgtacagagaacccgatgattgatgagg 2565 NM_172373 ELF1 gggctaatctggctgagtagtcagttataaaagcataattgctttatattttggatcatt 2566 NM_173624 FLJ40504 cagctttaacaaaaaattggccgtcaaaacctgagtcctgtcctcttgccctcctccccg 2567 NM_175870 LOC90925 aaaggaactcctgtcataaacattggatttcccgcggagtaacctggcgacatatttaga 2568 NM_177968 PPM1B gcagcgtgatgatacaacgtgttaatggttcattagcagtatctcgtgctctgggggact 2569 NM_181443 BTBD3 atagctgctgtgcaaattggtagaccttataagaaggcacttgtttgtaagccagagaag 2570 NM_181838 UBE2D2 aagagcacagtcttgtttggagagtctacataattactttgcactaacatttgcaggatg 2571 NM_182746 MCM4 cagagtgaatgttacaggcatctatcgagctgtgcctattcgagtcaatccaagagtgag 2572 NM_182776 MCM7 tctggcaggtcaatgcttcccggacacggatcacttttgtctgattccagcctgcttgca 2573 NM_198833 SERPINB8 aaccatacatcatctatgctttgtagtatgactcctgtcactcagtacaattattttgag 2574 NM_201593 CACNB2 ccacaacgagtgcaacaagcagcgcagccgtcataaatccaaggatcgctactgtgaaaa 2575 R99527 MGC39372 tccactgggtcaaaccatacatcgcttcgtctctgtagtgatgacttcctgtcctctgct 2576 T66903 LOC54103 catcctcggggtccagtgtctccctttgcataacctgctgcattgcattgacagtggagt 2577 U37028 ITGAD ctagaagaagacgaggtctacaatgccattcccatcatcatgggcagctctgtgggggct 2578 W56129 SFRS9 gttgctctactatggagatcaacagttactgtgactgagtcggcccattctgtttagaaa 2579 X58529 IGHM atgttaaccctgccgcgtggaatccccccgggaatcgaaattccgaacccaatgcagtcc 2580 AA188785 LOC286025 ttcctccaggtttttcaggggtcacttcacatttctaaagaaagagtgaataggctgggc 2581 AA347638 BCR aacttagagtctaaaagatttctactggatcacttgtcaagatgcgccctctctggggag 2582 AA601122 SECTM1 caagaggggcgcgtttgtgtctcgggttaaaataaggttccgtccgcgtgctgggtcaga 2583 AA642467 SLC2A14 gtcaaacatcacgaagacattggatgtggccccctgtgctgtggtcgcttcttggtcttg 2584 AA682722 LARP acacgtctaccataagtatcgtaggcgctgccttaatgagcggaaacgcttgggcattgg 2585 AA757235 LOC399933 ttggtatgtagaaatatatctgatttgcatactggtcctttatccagcaaccttcttaaa 2586 AA765313 FZD3 ttgcatgactgatagctgtaactcacagttaacatgctttcagtcaagtacagattgtgt 2587 AB002310 HUWE1 accgcactgtgttaaaccagatcctacggcagtccacgacccaccttgctgatgggcctt 2588 AB002333 ZNF518 gccatatcaggaaaataatgtcgagatatgtacttcttgcctttaagttttaacagccat 2589 AB024402 ING1 cgacttgcagagaaatgtctcgctgatgcgggagatcgacgcgaaataccaagagatcct 2590 AB028952 SYNPO ttgagaaaccggcagttcccaagccagcgcctggctgttctctcattgtcactgccctct 2591 AB032991 NDFIP2 gcgggtcgagtgctgtagttcgatttttgcgtgtgtgcgttgcttgcggcctttgtgcct 2592 AF008915 EVI5 gatgctatttatgatccaagtttttacatcacatccattgatctgcctatcccttctttt 2593 AF108138 C15orf20 tgcaaaatgtgcacccatattttaagctgctttttcaggggataaatagtgtttggggac 2594 AF116668 LMO2 aagggatttcttaggggatggtagacctttattgggtatcaagacatagcatccaagtgg 2595 AF143327 FLJ32810 tcaaagcttaacttctgtaggttccaaggagacacccaaagcttcaccaaacccagacct 2596 AF200348 D2S448 gacagagctataaactcaacccgaacacatttgtttgacagccgtcctcgttctccaaat 2597 AF245480 MONDOA ggagatatttctgtaactcattctcttggtgctcacgattgccatggccatagggccaca 2598 AI075159 SPTA1 ttgatgagcggacaaagcttggagactatgccaacctaaaacaattctaccgagaccttg 2599 BU948323 TCF4 cttcgtctgaaaaatgccaatattcaatcatcatgcagcattataacaagccttataagt 2600 AI675029 C7 gttttcagggagtacacaggtagattagtttgaagcattgaccttttatttattccttat 2601 AI694012 PSMA5 agtcaatacctgttagtgttaggctattaacaatagttaggtgaaaggtaatgagggcat 2602 AI732248 COL4A1 tactacgcaaacgcttacagcttttggctcgccaccatagagaggagcgagatgttcaag 2603 AJ007509 HNRPUL1 cttttattccgggcgtcttggtagtttctggtgggattcagtgggtgagagggaagaagg 2604 AK022224 ACTN1 tttctccaatctcatgtccattttggtgtgggagtcggggtagggggtactcttgtcaaa 2605 AK023928 PSCD1 gcacctgggtcagtattagtctatttatcagaggtgtaaataatctatgtatagtttttc 2606 AK024580 NRP1 tcacatttgcatcatagacgagacagtccattcatcttagttaaattggattgagaatgc 2607 AK025005 MARCH1 cttagctgggtcttccactcctaacggaattgagctcgttgatctgggatccaaaggtaa 2608 AK091853 COL3A1 cctcctgggattaatggtagtcctggtggtaaaggcgaaatgggtcccgctggcattcct 2609 AK126650 CAPZB agggacctacacacagaggagtgaacttagggttctagggactatggccgggtcaccggt 2610 AK127124 ARHGEF4 tatccacttgcctggtagaagtagcttgaaggtgagagagataaacaattgtcctcttcc 2611 AK127132 DRG1 ctagcagcttcaacccagtcctccttaccttgcacctattaacgttggttcaacatgaag 2612 AK129940 GNAI1 gaaaaggttagtctttcagtacacgttactggtaagtagtttccaagttacgtgttgtca 2613 AL049313 CLIC5 ggaagaaagtccatgagactttctgactaggaaaccatgtggtttgaacttgaagaaaaa 2614 AL049327 CBLB catgctaattcactctagttcaaatccacattctagttgaatccctgcaatgtaacttga 2615 AL049449 GAB1 ctgtggatttaaacaaattgcgaaaagatgctagttctcaagactgctatgatattccac 2616 AL050391 CASP4 catgatgagggatgggatgaaggcagcaaggggtaaccatcttgaccttctgttttttct 2617 AL137527 LRCH3 ccaactgcgtaaacatattgagtaccggttgaaagtgtctctaccttgtgatctcggagc 2618 AL353942 SEPT11 tctaattggatgtgctttcgcctttgcatgtaagtacggtagtaagaaacctttgagatc 2619 AL833915 TDRD9 agatgaaaacccccatgatggtgaattgaccttcttaggaagagttttagcccaacttcc 2620 AL834278 USP30 gaaagcattcattatgtccggagtgtctttttactcatctgatacaggtaattaaaagaa 2621 AU252485 MAP7 tccaccatgaatctttcgaaatatgttgatcccgtcattagcaagcggctctcctcttca 2622 AV650179 PRG1 tccaacaagatcccccgtctgaggactgacctttttccaaagacgagaatccaggacttg 2623 AV686223 KIAA1407 aaatacatgctgacgtggttccagcgtagtcaggaaagtctggctagaaagatggcccag 2624 AW014009 MAIP2K3 agttgtgtgaataccccaagactcccatgagggagatgccatgagccgcccaaggccttc 2625 AW190768 SLC13A3 cacccccttactctgctataatttctccttaataggacactgtataacttattttcttat 2626 AW292143 GFAP catagtgaccggctgcttttccctaagccaagggcctcttgcggtcccttcttactcaca 2627 AW439398 CCND1 gccaccacggcgttgtacctgtaggactctcattcgggatgattggaatagcttctggaa 2628 AW452039 HRMT1L3 gtttgctccaccagatttaaccaaatgtaactcccacattgagtttatctatattgaaaa 2629 AW664012 ALOX5 gttcacacctgatttttaagacttagaataaggaggtggggaatgtgaaatatctcattt 2630 AW967479 CD38 acaaataagcgagaaccgcgacgagcaccacataagccgtaggaccgcatgaaagaa gag 2631 AW970654 PHTF2 aaacattaccctaatgaggacgcccctaaatcgggtactagttgcagctctcgctgttca 2632 BC028066 NALP1 accaggaaccaccttggcaagatatttacccaccggccatctctgtttactcatgaatgt 2633 BC034289 LOC87769 acttactcttcaacttaatggcagactgtgatcgctaactgcatctggcacaaaaacatg 2634 BC042366 PCDH9 gtgtttaaagagggtcaagtggaggtgcatattccagagaatgctcccgtaggtacctct 2635 BC045532 LSM8 tacttggagatagtcacattagtacataggtgtcctttgcaactgctgtcaactctacat 2636 BC050383 TMPO ggggagataaatcagacttaacatgtatgtaagatcaattcacttaaaagtatggtccaa 2637 BC050602 HIST1H2AC tggtaagtgaactgaaaattccagtcactcttgggctagactcaacgttcttaaaaacta 2638 BC058855 VEGF ttaacatcacgtctttgtctctagtgcagtttttcgagatattccgtagtacatatttat 2639 BE147267 ECE1 agcaggggactgatggctatagcagaatgaggtcgggtcaggaccctcaaacaccatctg 2640 BE549606 BZW1 ttaactgaaaccggtactgatttggaagcagtagctaagtttcttgatgcttctggagca 2641 BE798965 LAMC1 acttacgtacgtggcataacacatcgtgtgagcccatgtatgctggggtagagcaagtag 2642 BE927772 SFRS3 tatccacctggtacctaagtcttgtcatggacttacaggtttgcatgggttccaaatact 2643 BF055235 RIPK1 tgagttctgtttgctccttgtaccaccatccaaatggtgttatcaaatctcttagattcc 2644 BF513638 WNT3 ttttagttctctagggtctgataggaacagacctgaggcttatctttgcacatgttaaag 2645 BG682263 HDAC3 taagagtggcttgggatgctgtgtcccaaggaatttcttttcacctcttggaagggctgg 2646 BG683220 PMS2 gacctctttgataggaatgtttgatagtgatgtcaacaagctaaatgtcagtcagcagcc 2647 BG747999 MT1L ccacggagaatacaacaacgatgcggcacgaggaaaagctggagtcagggaacaacc aga 2648 BI493513 PHF8 ggggttgggagtgttagtaatcaaggtttagaacaccatgagatagttacccctgatctc 2649 BI559738 GPR56 tggttaattctgtccaacaaacacacacgggtagattgctggcctgttgtaggtggtagg 2650 BM709325 BCL7A cccacttctctatgtaacgatataagctatcggagggtggtaccgatcaggaacgctttt 2651 BM711190 MED28 atctcttctgttgccctcgctaggttctccctggtgggttagtgctttgtatctgtctct 2652 BM727177 GOLT1B tttccagttgcactgtatctctggaagtgatgcatgaattcgattggattgtgtcatttt 2653 BQ009245 GPM6B atatgtcacactccttaatagggacctgtgactccttaataaggacctgtgacatgccca 2654 BQ021469 AGPS gattccctggagttcagtactgtaggaggatgggtatctactcgcgcatcaggcatgaag 2655 BQ215285 LEF1 acctaacaaaggcgtaggagtaacctcgcactttgctagctaacctgactccgggtgagg 2656 BQ898221 ITGA6 tcagtattcgggagtaccttggtggatcatcctagtggctattctcgctgggatcttgat 2657 BU929213 SESN3 aatgtaaggcagatgacgtgatctttaagactgctatatatatcagtctcttactctata 2658 BU954396 RPL11 aggctgcattggggccaaacacagaatcagcaaagaggaggccatgcgctggttccag ca 2659 BX095432 CNTN5 ttaagccttcgcagtttccacgtggcattgagcgttcgagtgcacagaactagaagtcaa 2660 BX640908 EVI1 aatccagtgctatccagtccataagccacgtatgacgttatcaaggttgaccagagtggg 2661 BX648339 USP53 gatcatataaacatgaccgagttgtacctcagagtcgagcttctgcacaaataataagtt 2662 BX648365 SEPT7 ctgctaaaatagaatatagcatctttcatatggtaggaaccaacaaggaaactttccttt 2663 BX649193 TKT tgtggcttgttctgcccatgtagactcaggtatatgaggacgttctgagtgggggtttgg 2664 C05886 ETV6 aatccacccggcgtgactcatttcaacactaagtactaggggtgttgtcaggagacaaat 2665 D31762 TRAM2 tcttatcttccatggatgctttaattggaagtgggttgccgacccccttgtgcctagaaa 2666 D86967 EDEM1 ttagccacatggtgagaccgtggtgaaagggggatggaaattgcttggccagtctttgcc 2667 H41942 NPEPPS catttctgggaatggttaaacacaaaaggctgatagctggtatcacatagttggagtcag 2668 M60028 HLA-DQB1 agggggcaaaggggagaacccccacatggtgaagaacttttcccgcgcactttttaaagg 2669 M77810 GATA2 ggctaggacagggtctcggactagggaagtggtttctctgcttaaaaagggtcagggtgg 2670 N26272 MSI2 ttgaatataagattcccaaacagaggagcataacacattcctagtacctaagttccaggt 2671 N28431 COL6A1 cctcagaatagtgatgtgttcgacgttttatcaaaggccccctttctatgttcatgttag 2672 N41620 WWP1 ctgtacagtgaattttccgaacctctcaaagtatgttttccgttcttccacagaaatatg 2673 N53163 COL27A1 tttgccatcagccgggtccagatgaatttcctgcacctgctaagctccgaggtgacccag 2674 N54946 EWSR1 aagcagtctgtcggatcctgtggggatagacgggcatttccctcgttgccccccttttta 2675 N70000 UBE3B ccctcattagcggattccgttccattatcaaacccgagtggatccgaatgttctcaactc 2676 NM_000016 ACADM gatttatgaaggtacttcacaaattcaaagacttattgtagcccgtgaacacattgacaa 2677 NM_000022 ADA cgccttcgacgagcccaaagtagaactgcatgtccacctagacggatccatcaagcctga 2678 NM_000024 ADRB2 ggaagtttacatcctcctaaattggataggctatgtcaattctggtttcaatccccttat 2679 NM_000033 ABCD1 attggattccctattcgtagccatctccgtggccaatgtgactaccgtgccagcagcggg 2680 NM_000062 SERPING1 tcatggagaaattggaattcttcgatttttcttatgaccttaacctgtgtgggctgacag 2681 NM_000089 COL1A2 cttttgccgtataaatagggcagatccgggatttgttattttagcaccacggcagcagga 2682 NM_000099 CST3 ttgaactcaggaaaccctcaaataggccagaacaactcactaattaaattcatcccctcc 2683 NM_000110 DPYD ggctttaaatcctcgaacacaaactcatgcaactctgtgttccacttcggccaagaaatt 2684 NM_000118 ENG catgtccttgatccagacaaagtgtgccgacgacgccatgaccctggtactaaagaaaga 2685 NM_000120 EPHX1 ccttttgagctattgcacacgcctgaaaagtgggtgaggttcaagtacccaaagctcatc 2686 NM_000147 FUCA1 gtcagtgcaaaaacaatgccagagctgtacgaccttgttaacagctataaacctgatctg 2687 NM_000169 GLA ctatgataaaccggcaggagattggtggacctcgctcttataccatcgcagttgcttccc 2688 NM_000182 HADHA gaaaaattgacagcgtatgccatgactattccatttgtcaggcaacaggtttacaaaaaa 2689 NM_000194 HPRT1 gcagtcaattttcacatcaaagacagcatctaagaagttttgttctgtcctggaattatt 2690 NM_000214 JAG1 ggaacaagttgagctatgacttaacatagccaaaatgtgagtggttgaatatgattaaaa 2691 NM_000234 LIG1 ttgctttttagcaaatctgctgtggcaggctgtggattttgagagtcaggggaggggtgt 2692 NM_000239 LYZ ggagtaggaattaagtgaaaggtcacactaccattatttccccttcaaacaaataatatt 2693 NM_000246 MHC2TA tttgtcacacactttggctattagagatcaaccccttcgctcctgtgtcttgcaatggca 2694 NM_000249 MLH1 tggagggactgcctatcttcattcttcgactagccactgaggtgaattgggacgaagaaa 2695 NM_000251 MSH2 tgttgcagagcttgctaatttccctaagcatgtaatagagtgtgctaaacagaaagccct 2696 NM_000277 PAH ctgcacctaatccccataacttccagtatcattttccaattaattatcaagtctgttttg 2697 NM_000305 PON2 gaaagctgctttcgaataaagtgaatacattttgcacaaagtaagcctcacctttgcctt 2698 NM_000341 SLC3A1 ttcgggccttcccgctaaaataagaataaggttaagtaccaattctgccgacaaaggcag 2699 NM_000361 THBD agtgggttacgggagacaacaacaccagctatagcaggtgggcacggctcgacctcaatg 2700 NM_000382 ALDH3A2 tcataaaattggcatcaattttaatgacgctcctggtatggaacctcagatataccctat 2701 NM_000395 CSF2RB acctccagtcccttgagaccccacgtcatgtagagaagttaacggcccaagtggtgggca 2702 NM_000417 IL2RA cgtacgtttcctgagaagtgtctaaaaacaccaaaaagggatccgtacattcaatgttta 2703 NM_000418 IL4R agggaaggcgggaaccttgggttgagtaatgctcgtctgtgtgttttagtttcatcacct 2704 NM_000435 NOTCH3 tgactgggatcccgtgtaccgagtacacgacccaggtatgtaccaagtaggcacccttgg 2705 NM_000448 RAG1 tagggcaaccacttatgagttggtttttgcaattgagtttccctctgggttgcattgagg 2706 NM_000484 APP gccaggcctcatacatactatttactggttctctttctgcgggtgctccaccaagaattc 2707 NM_000485 APRT ccgggtaggtgatgggtaacattccttaaatggtgcatgtcactggcctttcagctggga 2708 NM_000536 RAG2 tcaagcaaccctttggattatgcccatgaacaagttagtttctcatagctttacagatgt 2709 NM_000546 TP53 atctcttgtatatgatgatctggatccaccaagacttgttttatgctcagggtcaatttc 2710 NM_000561 GSTM1 ataagaagaactgtgcggcacagcgcccgctactacagctcgtcacacggtgttgtccga 2711 NM_000574 DAF atattgaagagttctgcaatcgtagctgcgaggtgccaacaaggctaaattctgcatccc 2712 NM_000578 SLC11A1 ccattgtgggctccgacatgcaggaagtcatcggcacggccattgcattcaatctgctct 2713 NM_000594 TNF caggggagttgtgtctgtaatcgccctactattcagtggcgagaaataaagtttgcttag 2714 NM_000598 IGFBP3 acactcagcgggcctaggcacgcgtggctcttgttgccttagctgaaatttctgttgtgc 2715 NM_000601 HGF ctacactggattgatcaactatgatggcctattacgagtggcacatctctatataatggg 2716 NM_000604 FGFR1 gccccagataggtggtgccagtggcttattaattccgatactagtttgctttgctgacca 2717 NM_000610 CD44 gattttgtagccaacattcattcaatactgttatatcagaggagtaggagagaggaaaca 2718 NM_000628 IL10RB ccttttatatcactaaaataagatcatgttttaattgtgagaaacagggccgagcacagt 2719 NM_000629 IFNAR1 tgtctaaaagttaaagcagcactacttacgtcatggaaaattggtgtctatagtccagta 2720 NM_000640 IL13RA2 agactttccatatcaagagacatggtattgactcaacagtttccagtcatggccaaatgt 2721 NM_000660 TGFB1 tgtgacagcagggataacacactgcaagtggacatcaacgggttcactaccggccgccga 2722 NM_000700 ANXA1 gatcctggaaagtaagcgcaaggctactctctaatgctaactcttatgtatgtaagaggt 2723 NM_000701 ATP1A1 ctctaccctggtaggaaagcaccgcagcatgtggggaagcaagacgtcctggaatgaagc 2724 NM_000717 CA4 acctgcgatgagaaggtcgtctggactgtgttccgggagcccattcagcttcacagagaa 2725 NM_000729 CCK agtgcgctctggtcgtctacaccctgaaaccctttgagttcgagtccgcttgctggtgct 2726 NM_000732 CD3D cctcgtaggccacaggggaaaaaggtccatttgtctcaccgggaggctcaatattgcctg 2727 NM_000773 CYP2E1 gcttgtacacaatggacggtatcaccgtgactgtggccgacctgttctttgcggggacag 2728 NM_000801 FKBP1A ccatattgcgcacaaacacccctatcacgaaaattacaccccccaacggcaacttttaca 2729 NM_000852 GSTP1 agcggatgctatggtgccggggcgacaaggtcgcaactataatctaaccgccttgctgct 2730 NM_000856 GUCY1A3 agacgtttagcgggatcatgactatgttgaatatgcagtttgttgtacgagtgaggagat 2731 NM_000867 HTR2B ataagacatttcgggatgcatttggccgatatatcacctgcaattaccgggccacaaagt 2732 NM_000878 IL2RB gtgacatatgtatctatacatccgtatcttttaatgatccgtgtgtaccatctttgtgat 2733 NM_000885 ITGA4 tggctcgccaacgcttcagtgatcaatcccggggcgatttacagatgcaggatcggaaag 2734 NM_000887 ITGAX tcagggcttcatcgtggggctctcagttccgatttcccaggctgaattgggagtgagatg 2735 NM_000905 NPY tcctgcaatgttaaccttggtcagcactcggcacacccctgcgcggtgcacataacagca 2736 NM_000906 NPR1 gtggcgcagaagggttgggggcctgtatgccttgcttctaccatgagcagagacaattaa 2737 NM_000953 PTGDR gcaactgaagcggagactctaaacccagcttgcaggtaagagctttcacctttggtaaaa 2738 NM_000960 PTGIR ctgctgcattgtgggtgatgacgtaggacatgtgcttggtacaaaaagggcctgagacat 2739 NM_000964 RARA ggagcccgtgggtgcacctgttactgttgggctttccactgagatctactggataaagaa 2740 NM_000967 RPL3 tgtagcctactgataactgcaaaggggagcttggaattatgttagtcagtccctgtgaat 2741 NM_000968 RPL4 ttggatctctgggcttttcaagattctgctaagatctgtattaatcatcttgcatggg 2742 NM_000970 RPL6 ggacatatctgtgaaccctccacggtggaaaaaatgccgcccttagtcgggtggggaaaa 2743 NM_000972 RPL7A caaataactggctggcttaacctatgagaagttctatctgacgatcagcttggaacagcc 2744 NM_001001547 CD36 ctgaagagcaaatgaatcctagtacattgaagagtaccgtactctatctggcacttaatt 2745 NM_001005 RPS3 gtgtagtaatgcgtatcagaggtagcggagaatgaagagcgacaagtgggacgagctgta 2746 NM_001009 RPS5 ggtaacaataccgggagcgcaacatacgtacacttctgtaacgcgcactgcacgtgtata 2747 NM_001015 RPS11 aactatttcttagcccatatattcatgtgtcatcgttcaggaacaagtcagtgacaaact 2748 NM_001019 RPS15A attttaatgccgcacatttgcatactatatgcttgttacagtgatccccacagtaactca 2749 NM_001069 TUBB2 cacagacaatactttaattgtaagaggagttccacatcattacatcaacagtgtgaattt 2750 NM_001079 ZAP70 cgataacctcctcatagctgacattgaacttggctgcggcaactttggctcagtgcgcca 2751 NM_001092 ABR ctgatgctccgtgctgttcgggaattgttttatgtacacttgtcaggcagaaaaggtagt 2752 NM_001130 AES gtctgtatatagtcagcttatctcgtgttcaatcgtctgatctctacagagagaagtgga 2753 NM_001150 ANPEP tacaccctgaacccggacttaatccggaagcaggacgccacctctaccatcatcagcatt 2754 NM_001165 BIRC3 cagggacacatttctctgtcttttttgatcagtgtcctatacatcgaaggtgtgcatata 2755 NM_001175 ARHGDIB tgttactttatctcccccaactgatatgttcatagaatgacagtttgtagatagaagatc 2756 NM_001178 ARNTL aagagaatactcgagcgcggagcgattccattgcatttccttccagtagccaggttttga 2757 NM_001207 BTF3 tgtgtcattgtattctttggttctgctcccccactattgaccaatgtatgagatgggaag 2758 NM_001211 BUB1B tcaagatggctgtattgtttggcaccaatatataaactgcttcacccttcaggatcttct 2759 NM_001219 CALU gtgcttctgaggaacaactctaattagtacacttgtgtttgtagatttacactttgtatt 2760 NM_001226 CASP6 cacctgcgcagatagagacaatcttacccgcaggttttcagatctaggatttgaagtgaa 2761 NM_001228 CASP8 ccagacacgtacaaaatccagctatgaatatagagggcttatgattcagattgttatcta 2762 NM_001229 CASP9 ctacacacaaaccagtatcgctcatagatcagcaaaccggggcctactagagtctgaaca 2763 NM_001237 CCNA2 taatacgaaagactggatataccctggaaagtcttaagccttgtctcatggaccttcacc 2764 NM_001239 CCNH aactatacagttgaactaaatatccagcagatacaacaagtagtcagaagttcaaagatg 2765 NM_001255 CDC20 aagcgcaagacgacaggaaacgaagcgagagacgagaagccggtgacgagcagga gaaag 2766 NM_001256 CDC27 ttcgatgatctcccataaacaaatgtaatgggcatattgggactcgtatgtaggaatcaa 2767 NM_001265 CDX2 gccagagtttttaaagccttctggatccatggggggagaagtgatatggtgaagggaagt 2768 NM_001273 CHD4 tagcagtgttatccactacgatgataaggccattgaacggctgctagaccgtaaccagga 2769 NM_001274 CHEK1 cggtgtgcttgggagtggcgattgtgatttacacgacaaaatgccgaggtgctcggtgga 2770 NM_001280 CIRBP gctcaattgaccgtcttttccagacctctttaagtcacactcttaacttagctttctctg 2771 NM_001295 CCR1 acttccactacccaaagacaaaatgtgcccactgtgtgcttttgagtgtattttctttta 2772 NM_001312 CRIP2 gggcagctggttttcttctgagccattagacccaatcgattctgtgttcccaactcggac 2773 NM_001313 CRMP1 ccagtccaacttcagcttatcaggtgcccagatagatgacaacaatcccaggcgcaccgg 2774 NM_001337 CX3CR1 gttccttcaagatcatgtaccccaatttacttgccattactcaattgataaacatttaac 2775 NM_001344 DAD1 taccacaccaaccagacgatcactgcatagtagcacatgacgagtactgcagtcgactcc 2776 NM_001345 DGKA accacagtctgaccgggctgcattgtgtatggtgccacctagagatccacgatgactgcc 2777 NM_001398 ECH1 tgctgcagacccaagacctcgtgaagtcggtccaggccacgactgagaacaaggaactga 2778 NM_001404 EEF1G aacttttagcatcaaacggggcatcttctcacacagtgcacttccgcccaagacagccgg 2779 NM_001428 ENO1 tttccaccaagtgtctagagtcatgtgagcctcgtgtcatctccggggtggccacaggct 2780 NM_001436 FBL acggacctggctagtgacccaaagaccgaagaaaccaagcgaacagccgaagcagat atg 2781 NM_001441 FAAH cccccatgtggcagcccatgggtatgacataggccaaggcccaactaacagtcaagaaac 2782 NM_001456 FLNA gactcaccaagggggatgcagtgcgagatgtggacatcatcgaccaccatgacaacacct 2783 NM_001462 FPRL1 aagagaaacttgtaatggtctctgaaaaggaattgagaagtaattcctctgattctgttt 2784 NM_001489 NR6A1 ggcccttgatggatctaaaactcggaacattactcctcaatgccgtttccccagttgctc 2785 NM_001513 GSTZ1 aaggcatcgactacgagacggtgcccatcaatctcataaaggatgggggccaacagtttt 2786 NM_001515 GTF2H2 cctagaagaatataatggagaaagattttgttatggatgtcagggggaattgaaagacca 2787 NM_001540 HSPB1 tacttttaccctcgcgcgctgattatccaccctgggcgagggataccgatgtgtcccagt 2788 NM_001560 IL13RA1 gtctgcaagtggggtcccagtgtagcaccaatgagagtgagaagcctagcattttggttg 2789 NM_001607 ACAA1 ttgaaagggatactagcctgcagtgggcatctgtcaccgtgtgtgtgcccaagtgggagg 2790 NM_001630 ANXA8 aactacaaattcctgacccaaggacactgtgttataagaggcgtgggctcccctggtggc 2791 NM_001640 APEH ccggaatgtgcctgttcggctcctgctctatcccaaaagcacccacgcattatcagaggt 2792 NM_001654 ARAF tctcaagtctaacaacatcttcctacatgaggggctcacggtgaagatcggtgactttgg 2793 NM_001664 RHOA ggtgggccagacgggttggacatcgttaataatcatagttggcttctaaatactggtagc 2794 NM_001712 CEACAM1 gaggattagcttggagttctctatactcaggtacctctttcagggttttctaaccctgac 2795 NM_001715 BLK cagtcctgaacaccttactggggcttagtactccggatgaccgtgcgaggtcactgttac 2796 NM_001716 BLR1 ctcccttcccataagctatagacccgaggaaactcagagtcggaacggagaaaggtggac 2797 NM_001728 BSG cgccggagtccactcccagtgcttgcaagattccaagttctcacctcttaaagaaaaccc 2798 NM_001734 C1S ttcattaggtccatctgatagtcatgtagggtaggcggaactgataggatttctgtttta 2799 NM_001743 CALM2 tgcaaaacgggtgtattatccaggtactcgtacactatttttttgtactgctggtcctgt 2800 NM_001747 CAPG agcacgcacaaggaacgcaccagatcaaccgacagcagaacgcacgagagccaaga ccat 2801 NM_001752 CAT tagagaatcccactttctatagcagattgtgtaacaattttaatgctatttccccagggg 2802 NM_001753 CAV1 cctcacagttttcatccagccacgggccagcatgtctgggggcaaatacgtagactcgga 2803 NM_001759 CCND2 tatgcgaaaaggtttttaggaagtatggcaaaaatgttgtattggctatgatggtgacat 2804 NM_001767 CD2 cactcaaagccatctgatgctcacatttcatgtagtcagaggaggccatctggtttgaat 2805 NM_001772 CD33 tacattcctgcaatgcatatcattcagacataaagatgggccgaagtacagatacatgct 2806 NM_001774 CD37 ctgctacaacttgtcggcgaccaacgactccacaatcctagataaggtgatcttgcccca 2807 NM_001776 ENTPD1 ctgcccccatattcaacaatctaaccatactgagctgctgattccccagggattgcatat 2808 NM_001783 CD79A ggaaacgacactaggtcgcacagggcatagacgatagtaccattcctggttgaaacacga 2809 NM_001786 CDC2 ttggtcagagtaataactgaaggagttgcttatcttggctttcgagtctgagtttaaaac 2810 NM_001793 CDH3 aggacaccttccgagggagtgtcttagagggagtcctaccaggtacttctgtgatgcaga 2811 NM_001794 CDH4 gggaaggcgcacttggtgctatgagccctccaagtattaaccttacacagagcccccgct 2812 NM_001795 CDH5 tagacaaggacataacaccacgaaacgtgaagttcaaattcaccttgaatactgagaaca 2813 NM_001798 CDK2 ggagcttgttatcgcaaatgctgcactacgaccctaacaagcggatttcggccaaggcag 2814 NM_001830 CLCN4 aagctatgtattaggtccaccatacgatctgtgtaagtaagattatcccacttgcccttt 2815 NM_001838 CCR7 tcaaagccacactctgggctccagagtggggatgacatgcactcagctcttggctccact 2816 NM_001839 CNN3 ttgtgccaatgtatcaatgtagagttgctctgttttcttcaactgtatttattgctgcat 2817 NM_001897 CSPG4 agagtcctggcactggctaggggtgtcaatgcatcagccgtagtgaacgtcactgtgagg 2818 NM_001901 CTGF cagtttatttgttgagagtgtgaccaaaagttacatgtttgcacctttctagttgaaaat 2819 NM_001905 CTPS gaacctcaagtgtgtgttattgagcttggtggaaccgtgggggacatagaaagcatgccc 2820 NM_001908 CTSB aaagatgcttaacaaaggttaccataagccacaaattcataaccacttatccttccagtt 2821 NM_001916 CYC1 cttgaacctcaacacgacagccaacgtgcataagcatgcaacactaccgaggtagccaca 2822 NM_001923 DDB1 tgactgccaagccatgggtagcctgggtgtaaaacctggagatggtggatgatccccacg 2823 NM_001928 DF gacagagcgcagtagtgattagtcgtatttcgcgacacctcacacggtagatgtgatcaa 2824 NM_001939 DRP2 ggactttgccacaaccttaaagaacaaattccgctccaagcattatttcagcaaacaccc 2825 NM_001941 DSC3 ctgtaaccagaagccagttttatctaacggctactgaaacacccactgtgttttgctcac 2826 NM_001952 E2F6 tgttgagtcagtccaaggggttttacttaggacaagttgtaccttgccctctctccagct 2827 NM_001964 EGR1 gtttggcttataaacacattgaatgcgctttattgcccatgggatatgtggtgtatatcc 2828 NM_001993 F3 acatgctttagattatatattccgcacttaaggattaaccaggtcgtccaagcaaaaaca 2829 NM_001999 FBN2 ctgctgttgaacagatcagcctagagagtgtcgacatggacagccccgtcaacatgaagt 2830 NM_002015 FOXO1A gcatttcgctacccgagtttagtaacagtgcagattccacgttcttgttccgatactctg 2831 NM_002017 FLI1 gtcgaagtctacccaatatcccccagtaagagaataaggggcaagaatgactcatgaact 2832 NM_002023 FMOD ctggggagcacttaattcttcccatttcaaaagtaatgttgcctggggcttaacccacc 2833 NM_002033 FUT4 gtaacctcttcaactggacgctctcctaccgggcggactcggacgtctttgtgccttatg 2834 NM_002046 GAPD ccccccacacaaaagcccctttggtgtgaaaaacggcccccacaagtttataaaaggggg 2835 NM_002049 GATA1 caagaagcgcctgattgtcagtaaacgggcaggtactcagtgcaccaactgccagacgac 2836 NM_002064 GLRX cttgaaaactcttctggcgtaaaaacattctcgagttaataatgttaccccttataacag 2837 NM_002065 GLUL agtatgttcaaagtcaaataactcctcattgtaaacaaactgtgtaactgcccaaagcag 2838 NM_002067 GNA11 ttaagttattgacgcccagcgcgcctcgcctcttcacccatcaacgctgtgctttgccca 2839 NM_002068 GNA15 aatctgcagccgctccatggcctcgatcatggcccgcatggacacgaagatgttctggta 2840 NM_002076 GNS tttgacttagaaagtgcccttcaaaaggaccctgttcactgctgcacttttcaatgaatt 2841 NM_002086 GRB2 tcagtgtttaaataaagacctatgtacttaatcctttaactctgcggatagcatttgta 2842 NM_002090 CXCL3 gaaccctcgtaagaaatagtcaaacacattaagtcctttccagctgtccctagaaagctg 2843 NM_002094 GSPT1 ctcccttggcgatctgcaggaacactagtaatgactggaattactccgtgatctttgatg 2844 NM_002102 GYPE catcctgtaacattggcttacctgtatattatatgccacccgtaaccataaaaacaccag 2845 NM_002107 H3F3A tttgagaggtgattgatactgctaacaattttctagtactctagtttgtttcaagaagag 2846 NM_002108 HAL tcggatgctcttggctttaaggatcaatgtcttagccaaaggatacagtggcatttccct 2847 NM_002110 HCK ttgactcttgcaatccacaatctgacattctcaggaagcccccaagttgatatttctatt 2848 NM_002118 HLA-DMB caaggctatatttctgggatgaatataatctgaggaagggagttaaagaccctcctgggg 2849 NM_002121 HLA-DPB1 gttaactattgtataatgtggcctgttatacatgacactcttctgaattgactgtatttc 2850 NM_002128 HMGB1 acccctcttcaatctgaagattagtatggtttggtgttctaacagtatcccctagaagtt 2851 NM_002129 HMGB2 ttgtagctttttgatgggctactcatacagttagattttacagcttctgatgttgaatgt 2852 NM_002135 NR4A1 cggcctttatgttttttgtaagataaaccgtttttaacacatagcgccgtgctgtaaata 2853 NM_002141 HOXA4 tttaagacactgttacagagatactgttgtcaccttctggggcacggtctttggggagag 2854 NM_002145 HOXB2 gcactcggttatcttttaaaattcacacagaaaaattccgtttggtagactccttccaat 2855 NM_002166 ID2 cgactacatcttggacctgcagatcgccctggactcgcatcccactattgtcagcctgca 2856 NM_002167 ID3 acaggaagagagaagaagcgacagccacggaaacaagcaacgccacagagacacga gggc 2857 NM_002186 IL9R cggcctgtgtgaacctgtcgtgcaaagctcacgtcaccaactgctgcagttatctcctga 2858 NM_002193 INHBB tccaagtgccacgtgaactatgcaatttaaagggttgacccacactagacgaaactggac 2859 NM_002198 IRF1 cccctcttattcctctaggcaagcaggacctggcatcatggtggatatggtgcagagaag 2860 NM_002199 IRF2 tctttaggccttgtctgtaaaacgaatggctcaggctaagtgatctctaaatgcctaaat 2861 NM_002222 ITPR1 ataattattattagtgtgggtatggctaatgagttctgattcacccacgaaggttacatt 2862 NM_002224 ITPR3 cttgtacttcattgtgctggtccgcgtgaagaacaagaccgactacacgggccctgagag 2863 NM_002228 JUN aagccgggtagcgcgcgcgagtcgacaagtaagagtgcgggaggcatcttaattaaccct 2864 NM_002229 JUNB aaaatggaacagcccttctaccacgacgactcatacacagctacgggatacggccgggcc 2865 NM_002230 JUP gtaaagtggagccagtgatagtagttaccttgcagggtcgttgtcaggttatgtgagaaa 2866 NM_002248 KCNN1 gaaaaacctgttcccatcaccggcctagcctagaatcctagcctagaagccctctctccc 2867 NM_002276 KRT19 atcacaaccataacccacccacacaaacgatagagactcaataaaacatgtccagctgtc 2868 NM_002295 LAMR1 cagcgcaatggtaggtaggttaacataagatgcctccgtgagaggctggtggtcagccct 2869 NM_002312 LIG4 aacattttgcccgtgaatatgattgctatggtgatagttatttcattgatacagacttga 2870 NM_002341 LTB ggtagatgtataggcagcatgagtggttaagagtcaagggagtagccggggtagtggcttac 2871 NM_002349 LY75 gaagccgtcctgtactgtgccagcaatcacagctttcttgcgactataacatcttttgtg 2872 NM_002351 SH2D1A taagcgaggttccccgtgtgtaggtagatctggtctttagaggcagatagataggtcagt 2873 NM_002353 TACSTD2 gaaggcttaaatgagtttagatgggaaatagcgttgttatcgccttgggtttaaattatt 2874 NM_002356 MARCKS ccaagctgtgataagtggaatggttactgtttatactgtggtatgtttttgattacagca 2875 NM_002379 MATN1 cttgcccttcactcatcgcagttctccccacggctactccaggtcctcttgaaatccgtc 2876 NM_002388 MCM3 ttctctagttcgtcccaaagtcgtccgcagtgtccactactgtcctgctactaagaagac 2877 NM_002390 ADAM11 ggtacggcaaccacatgtcccagatcgtctccaattcgaaaacaaccgtcctgctgtccc 2878 NM_002392 MDM2 gacctactttggtagtggaatagtgaatacttactataatttgacttgaatatgtagctc 2879 NM_002393 MDM4 tctgattagtcaaattattaagtgccatggattactttatgcagcagtcaggtacatagt 2880 NM_002398 MEIS1 ttagagctgcttaaaacaggaagtgatgtataaggtggtggttgttgcatggggacaatg 2881 NM_002412 MGMT agtaggatggatgtttgagcgacacacacgtgtaacactgcatcggatgcggggcgtgga 2882 NM_002414 CD99 caaccaccctagttcctccggtagcttttcagatgctgaccttgcggatggcgtttcagg 2883 NM_002415 MIF cccccgcgaaaacccgcccagcttttattgcccccgttccaaatttctccctatgagtta 2884 NM_002417 MKI67 acttgtactatattggctgccatgatagggttctcacagcgtcatccatgatcgtaaggg 2885 NM_002419 MAP3K11 aagcgcgagatccagggtctcttcgacgagctgcgagccaaggaaaaggaactactga gc 2886 NM_002421 MMP1 accccaaaagcgtgtgacagtaagctaacctttgatgctataactacgattcggggagaa 2887 NM_002422 MMP3 gagaaggggaagcactcgtgtgcaacagacaagtgactgtatctgtgtagactatttgct 2888 NM_002436 MPP1 cgtttttaactgcaactttctataatgccaaaatgacacatctgtgcaatagaatgatgt 2889 NM_002441 MSH5 ccgaaattggggcagtagacgccatcttcacacgaattcatagctgcgaatccatctccc 2890 NM_002444 MSN gaagatcctaccccaattccttgtaggagtataggccggtctaaagtgagctctatgggc 2891 NM_002447 MST1R cacctcgcatgagatgaatgtgcgtccagaacagccgcagttctcacccatgccagggaa 2892 NM_002460 IRF4 gttttacatgccccgtttttgagactgatctcgatgcaggtggatctccttgagatcctg 2893 NM_002462 MX1 tgtgtgtgcgtcctgtcggagccctgtctcctctctctgtaataaactcatttctagcag 2894 NM_002466 MYBL2 cagcctcaccctgtcaggtatcaaagaagacaacagcttgctcaaccagggcttcttgca 2895 NM_002475 MLC1SA cctacacatctcatgacacgcgcccaccctatgcgcgttttcacaaactccgaagaacgc 2896 NM_002483 CEACAM6 ccagtctacttgagttagcataatacagaagtcccctctactttaacttttacaaaaaag 2897 NM_002512 NME2 cttcattccattgacttagaggcaaccaggattgaccattcttttatagagctatttgcc 2898 NM_002514 NOV acggcggtagagggagataactgtgtgttcgatggggtcatctaccgcagtggagagaaa 2899 NM_002527 NTF3 tcactctgtaaaatctgtgtacaccagtattttgcattcagtattgtcaaggccatgact 2900 NM_002530 NTRK3 ggaatatcacttccatacacatagagaactggcgcagtcttcacacgctcaacgccgtgg 2901 NM_002572 PAFAH1B2 atgtgttctcggtcgccgtagacagcgctctggctaccaccgtgaggctacttgaactgt 2902 NM_002576 PAK1 ccattgactaccttctcatgctctgaggtactactgcctctgcagcacaaatttctattt 2903 NM_002585 PBX1 tggcaggatgctactaccccttcatcagtgacctcccctacagaaggccctggcagtgtt 2904 NM_002592 PCNA accgacgaatgacactgacagccgacgaatacccacaacacgctaaacggtagccaca gc 2905 NM_002600 PDE4B tactatcattgtggctttggttcaaaaggaaacactacatttgctcacagatgattcttc 2906 NM_002608 PDGFB tattgtttccctcgtccgtctgtctcgatgcctgattcggacggccaatggtgcttcccc 2907 NM_002609 PDGFRB ggggctttttctttatcaccctcagtcttaatccatccaccagagtctagaaggccagac 2908 NM_002616 PER1 gagtcctccaatcaggacgcactttccggctccagtgacctgctcgaacttctgctgcaa 2909 NM_002621 PFC tttcggaggtaaaagaaagtagctcatgccaacaagtaacattcaccagcatttattgag 2910 NM_002648 PIM1 catcatgagttctgctgaatgccgcgatgggtcaggtaggggggaaacaggttgggatgg 2911 NM_002658 PLAU gtaacagctgaggtctcttgagggagcttagccaatgtgggagcagcggtttggggagca 2912 NM_002659 PLAUR tgactgccagactgtggggaggcactctcctctggacctaaacctgaaatccccctctct 2913 NM_002687 PNN gaattcccggtccgacagaaagaggtctatatcagagagtagtcgatcaggcaaaagatc 2914 NM_002704 PPBP ccaaagtttggaagtgatcgggaaaggaacccattgcaaccaagtcgaagtgatagccac 2915 NM_002729 HHEX agtacctcccaattcaagcagagaaactgacctgactaaagttaatcgcagatgaactag 2916 NM_002730 PRKACA tgaaacagatcgaacacaccctgaatgaaaagcgcatcctgcaagctgtcaactttccgt 2917 NM_002744 PRKCZ acgcccacgtcagggtgaccatctgtggtaaccgagaattccttggaggcagcgtcttca 2918 NM_002753 MAPK10 catgtgatctattactctgacataaacccatctgtaatatattgccagtatataagctgt 2919 NM_002758 MAP2K6 atcttggcagaactttctatatcgcctatagactgatttgcttagatctcttataatttg 2920 NM_002791 PSMA6 acacgcagagagacgtaagcaaaacctaagacgcaaagagcgaagcgactaagaaga agg 2921 NM_002800 PSMB9 gcagttaccatacgagaaatcaaggtcgttgggacggaagtaaccttatctgcttttccc 2922 NM_002814 PSMD10 cttgttttccaggcatcgaataactgttgagattgttctactgttgtcgtatattcttct 2923 NM_002827 PTPN1 taaactcaccttgcttacttcccccttctaaacaacaatcccaacccttacgccatggtg 2924 NM_002831 PTPN6 gtctccccgctggacaatggagacctgattcgggagatctggcattaccagtacctgagc 2925 NM_002835 PTPN12 aatctctaagccacaggaattaagttcagatctaaatgtcggtgatacttcccagaattc 2926 NM_002844 PTPRK gctaaaaaacgcaaagatgccatggggaatacccggcaggagatgactcacatggtgaat 2927 NM_002856 PVRL2 agggttccagactggttggacttgttcgtctggacgacactggagtggaacactgcctcc 2928 NM_002868 RAB5B tcttcctctcccaacataacaatcgtggtaacagaatgcgactgctgatttaccgatgta 2929 NM_002870 RAB13 ttactagatcaggttttagggtcctgcaaaaggctagctcggcactacactagggaattt 2930 NM_002880 RAF1 gatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtctgtttcc 2931 NM_002887 RARS atattgaaggtgaacatgtggcgtatgctgctatgtgaagcagtagctgctgtcatggcc 2932 NM_002893 RBBP7 cccagttggaatactgatagctctaaaaacttagtaaaacctttgttaggattaacagga 2933 NM_002901 RCN1 aaacggagcggagttctggatcatgtcccatccagtccagtgaatccacgacccgcagac 2934 NM_002908 REL gcaaaatgagcaattgagtgactcctttccatatgaattttttcaagtataacttgcaag 2935 NM_002913 RFC1 aaggaagcccaccttactccatactcacttcaagctataaaggcatctagacacagcaca 2936 NM_002934 RNASE2 gacctgtcctagtaacaaaactcgcaaaaattgtcaccacagtggaagccaggtgccttt 2937 NM_002935 RNASE3 tgtgggttgagacactatagagtgtgtcataaccgagaccggataggggagtagttactt 2938 NM_002936 RNASEH1 atgcattagttgtctgtcaaggaaggtgagtggtgaagggtttttacatatatacaagaa 2939 NM_002953 RPS6KA1 ctgtttagcagaactcattctatccccaatcagctccttttccgttctgttctgctggga 2940 NM_002960 S100A3 gccacctggaccccgactgagtttcgggaatgtgactacaacaaattcatgagtgttctg 2941 NM_002961 S100A4 tcgcatacaatcatgtctcacagcgctgatcttagcacattatgtcatgtttccatctca 2942 NM_002971 SATB1 aaaatgtgctttacacagttgcctataaaaagtgctctatgttatccaagcaattcatac 2943 NM_002972 SBF1 aagtctgagcccttccgcatttctccggtcaaccgcatgtatgccatctgccgcagctac 2944 NM_002975 CLEC11A tgctgatctcgtggacatgcttccgctccagctgttagcgacttgagctcgtcttcacag 2945 NM_002983 CCL3 accagttctctgcatcacgtgagtctgagtttcgttgtgggtatcaccactctctggcca 2946 NM_002984 CCL4 cacaaatcaacggttgttatatgtagtttaaaacctaaccagtgtgcggggaatttttct 2947 NM_002985 CCL5 acttcagattctacattaccactcaaacgcgaaacacaatcaaaatacccgagagaccgc 2948 NM_003002 SDHD acaggtgtctaacgggcaatcgcctagaaacgatagagacagaacgcatgcgcgcagg cg 2949 NM_003005 SELP gtgaggctatttcgtgtgagccgctggagagtcctgtccacggaagcatggattgctctc 2950 NM_003006 SELPLG caaggaagatggagctcccccatcccacacgcactgcactgccattgtcttttggttgcc 2951 NM_003009 SEPW1 tcctcctgtcccgtggtttcatcatatctctttgcataccccatgtcttccccagttgtc 2952 NM_003025 SH3GL1 tggaccggtggctagcaatatcgtgtgttgcgcactcgtaaagtgtgttatttcaaccct 2953 NM_003038 SLC1A4 gtcggtagaccaggggttacgtgactggggaaaatctcacatctccttgtctgaaaacat 2954 NM_003039 SLC2A5 gaagacttccccttgacgttgctgtggtctgtaaccgtgtccatgtttccatttggaggg 2955 NM_003058 SLC22A2 tgcttgggaagaatggggatcacaatggcctatgagatagtctgcctggtcaatgctgag 2956 NM_003072 SMARCA4 tcatcatcgtgcctctctcaacgctgtccaactgggcgtacgagtttgacaagtgggccc 2957 NM_003073 SMARCB1 ggaggaccagtcagaccagcgcgtcatcatcaagctgaacatccatgtgggaaacatttc 2958 NM_003100 SNX2 ctcctagaattgaatcaaagagtatgtctgctcccgtgatctttgatagatccagggaag 2959 NM_003113 SP100 tttgaatgagcagacgtacacccgagtagaagggtttgtgcaggacatgcgtctcatctt 2960 NM_003118 SPARC caagtactaggcgtggatatctggataatgaaggagtgtgaattaagaaggagtaccagg 2961 NM_003120 SPI1 ttgggaagttcccaactttcccgttagggtaaaatccgaaattttcccctttttaaaccc 2962 NM_003121 SPIB aggaggaaggaatgccaatgacctagagacacgagaagtccatgtggaggcacacagc ag 2963 NM_003123 SPN cgcttttcataatgtgcaaagtcatcaaagattgaggtggtatgcttgaaagtagcaatt 2964 NM_003127 SPTAN1 tgcaggcctttgccgaccagctcatcgctgccggccattatgccaagggagacatttcta 2965 NM_003128 SPTBN1 caggactatgagcatgtcacgatgttacaagaacgattccgggagtttgcccgagacacc 2966 NM_003133 SRP9 cacatttaaactacctgttaatataagggatttgtagtatcagcttgttgagcaatgact 2967 NM_003159 CDKL5 cccaacccagcaatccgggttctctttcttcgtgagacacgttatgagggaagccctgat 2968 NM_003189 TAL1 gcccagcactttccgtcaacgttgtactgtatgtgatgaattgcgttggtctctgcattt 2969 NM_003200 TCF3 tggcctcgatctactccccggatcactcaagcaataacttctcgtccagcccttctaccc 2970 NM_003222 TFAP2C tctatttaattgaaactctctgttcagaaagcaataactttgtctcgttcctgttgggct 2971 NM_003225 TFF1 agaggaccgccagcgcgcatagagagatcggtgcgcggacagatttgtctcgaacatagt 2972 NM_003234 TFRC gcttgaagatcgttagtatctaacatgtatcccaactcctataattccctatcttttagt 2973 NM_003262 TLOC1 agaggtctgtgaattgtaggttaagaacccctgccctagctaatcagatccaccaatgtt 2974 NM_003288 TPD52L2 ccacaggtcacgctcaggacccgcatctcattccgatcctccttgtgtgggtggtactta 2975 NM_003302 TRIP6 agttcccatcctttgattgatcactctccctgacatccacctgtatgactttgtcaccaa 2976 NM_003311 PHLDA2 taatctttcaccgccccagcgcagacctgggaagcggaaaatcccgccgtattttcccag 2977 NM_003315 DNAJC7 acttacataaaagcctacttgagaagagctcagtgttacatggacacagaacagtatgaa 2978 NM_003318 TTK aatcactggcagattccggagttagcccgaaaagttaatacagagcagaaacataccact 2979 NM_003352 SUMO1 tatgatccaggccgatctacagtcattcaccgggggtaggagagtcacacaagtacaacc 2980 NM_003361 UMOD ttctcaaaatgggacttgtgacggtgtacctgaggcccccatctccttaaagagtgtggc 2981 NM_003383 VLDLR cagtctatggtgccaataaattcactggatcagagcatgccactctagtcaacaacctga 2982 NM_003390 WEE1 gccctactcccacgtatccaacctagtctaccctagaatccactaacgctttattatgtt 2983 NM_003395 WNT9A tgtctgctagctagttggtttctatacaaatacatattcgaatgtcttgctggatgaaga 2984 NM_003403 YY1 agttgctgagtgggttgatctctggtctttccttgacagtgcacgttcgaaggctgtggg 2985 NM_003415 ZNF268 gcatataccttggagggaccatgctatgagggaaagtgtaaatctagaaatgagaaaccc 2986 NM_003425 ZNF45 tttaacttttatggtttggtcgtaggatcagcagggctcgcacttcggtcagcaggaaaa 2987 NM_003427 ZNF76 ttggcaccagggacttcctgacaccacagtcaattaattcctcaggggcctgtggctgga 2988 NM_003453 ZNF198 atgctcttgatacagagttgcttacaatgacggatatgatgagtgaagacgaggggaaaa 2989 NM_003467 CXCR4 agggaactgaacattccagagcgtgtagtgaatcacgtaaagctagaaatgatccccagc 2990 NM_003480 MFAP5 gtcaacaaggagatctgctctcgtcttgtctgtaaggaacacgaagctatgaaagatgag 2991 NM_003549 HYAL3 ttttcctatggagggaaccttgggtaggtttgagcagggggtatagtgtctgctttgcat 2992 NM_003582 DYRK3 ggagcatcttaagaaacaggataaaactggtagtatgaacgttatccacatgctggaaag 2993 NM_003627 SLC43A1 aagggacctggatgacaggcaatcaaggcctgagcaaccaaaaggagtgccccatatg gc 2994 NM_003636 KCNAB2 aaacgagactcagaccgcgacacagccaccgtatttatggaatgacaaaataaataaagc 2995 NM_003645 SLC27A2 gaagattgtgaggaaattttgtaggaaatttgcatacccgtaaagggagacttttttaaa 2996 NM_003692 TMEFF1 cacatggtaattctaagacttgttctttacccatggaatgtaatatttttgcaaagatgg 2997 NM_003701 TNFSF11 agtatcttcaactaatggtgtacgtcactaaaaccagcatcaaaatcccaagttctcata 2998 NM_003707 RUVBL1 aactgttcctgtggttgctttgaaagaacccttccttacctggtgtgttttctataaatc 2999 NM_003739 AKR1C3 tcttctatttcacacaagacttctcccgccgtattggttgcggaccttgcgcggccggag 3000 NM_003746 DNCL1 ggagtgacgcgataaaacgccgaacggaacacgaactgcgacactgaaagaacccac ccg 3001 NM_003753 EIF3S7 tgaccttattgtccgttgtgagcacgatggcgtcatgactggagccaacggggaagtgtc 3002 NM_003801 GPAA1 ggccctaaccctgcgtggcatcaatagcttccgccagtacaagtatgacctggtggcagt 3003 NM_003805 CRADD tcttcctaagtggtagatctaaataccataaatggtggctagctttataggaaaacccat 3004 NM_003821 RIPK2 tttggtttatcaaagtggcgcatgatgtccctctcacagtcacgaagtagcaaatctgca 3005 NM_003824 FADD cgctcttgtcgatttcctgtagtgaatcaggcaccggagtgcaggttcgggggtggaatc 3006 NM_003842 TNFRSF10B tatttgggctacattgtaagatccatctacacagtcgttgtccgacttcacttgatacta 3007 NM_003852 TIF1 caacagaagggtaggttagatgctattaagaaggcacttaatagtacatcatgtaagatg 3008 NM_003874 CD84 aatgaatccatagactcatctagcaccaactaccattagcactatgttaggagctgcaag 3009 NM_003877 SOCS2 gctagaacatttactaatgccaggtgttgcatttgacactttacaagtataacctcactg 3010 NM_003879 CFLAR gacgtcgaggcattacaatcgcgaaaccaagccatagcatgaaacagcgagcttgcagcc 3011 NM_003884 PCAF atgcgtccagggtcataaccccctaaaatccatcatgcaaccttattaatctgtcttggg 3012 NM_003900 SQSTM1 gtccacatgtgaactttttctaggtggcaggacaaatcgcgcccatttagaggatgtggc 3013 NM_003902 FUBP1 agttatttacaattcgtggcactccacaacagatagactatgctcggcaactcatagaag 3014 NM_003914 CCNA1 cacttgccagttgttccggacacatagaaagataacgacgggaagagcggggcccgcttt 3015 NM_003954 MAP3K14 ggtctggaatacctccactcacgaaggattctgcatggggacgtcaaagctgacaacgtg 3016 NM_003955 SOCS3 aacccatgcctcccagctgagcactgggaatgtcagcccagtaagtattggccagtcagg 3017 NM_003974 DOK2 agctgtacgactggccctacaggtttctgcggcgctttgggcgggacaaggtaacctttt 3018 NM_003998 NFKB1 gttgtccctctgctacgttcctattgtcattaaaggtatcacggtcgccacctggcattc 3019 NM_004039 ANXA2 tttatttctcttatcgctccttctaagtacacagacggaagggacaaggagcggaacagg 3020 NM_004047 ATP6V0B tatattaccggctcctccatcattggtggaggagtgaaggcccccaggatcaagaccaag 3021 NM_004064 CDKN1B aagactgatccgtcggacagccagacggggttagcggagcaatgcgcaggaataagga ag 3022 NM_004067 CHN2 gttattaccctgtgtaccttgtccctcattttgctgtgacaccctgaaaaagctgaccac 3023 NM_004077 CS gaaccacactgttgagttggacacactgtaaacccctgggtaactgtcaagtcatgatgg 3024 NM_004083 DDIT3 tgatgtgaccctcaatcccacatacgcagggggaaggcttggagtagacaaaaggaaagg 3025 NM_004088 DNTT caaagcccactttgttcgcagtgtagctgaaatactgtctatctctaataaaaacaggag 3026 NM_004093 EFNB2 gaagagcccgtcgcgctggacagcttacctagtcttgtagcattcggccttggtgaacac 3027 NM_004099 STOM agatgagcgctagccttccaagcatgaagtcggggaccaaattagcctttaactcataaa 3028 NM_004104 FASN gaaatttactgtaactgtcagtgtacacgtctggaccccgtttcatttttacaccaattt 3029 NM_004111 FEN1 tctagttattcagaggagtaagatggtgatgttcacctggcaatcagctgagttgagact 3030 NM_004119 FLT3 tttccttgtgagcaaaagggtcttgataacggatacagcatatccaagttttgcaatcat 3031 NM_004177 STX3A atgatactgatgcggttgagattgctatcgacaacacggcttttatggacgagttctttt 3032 NM_004208 PDCD8 ttgggaaggaggcgggtagagcaccatgatcacgctgttgtgagtggaagattggctgga 3033 NM_004221 NK4 ccgaggagcctaggggagagctttagtgacaaggtcatgagatggttccaggccatgctg 3034 NM_004235 KLF4 caaactgctgcatactttgacaaggaaaatctatatttgtcttccgatcaacatttatga 3035 NM_004310 RHOH gtttttggaattgcttccctttccccacaagaacaaagcactggccgggtaaggtggctc 3036 NM_004313 ARRB2 gaatggggtggtagacttggaagagggatgggctagttggcaggatttcacgtttctgct 3037 NM_004320 ATP2A1 gctcgacgaaatcctcaagttcgttgctcggaactacctagagggataactgttccccct 3038 NM_004324 BAX aactgatcagaaccatcatgggctggacattggacttcctccgggagcggctgttgggct 3039 NM_004335 BST2 tgggagctggggtagtacttcttgtccgcgattctcacgcttaagacctggttttctctt 3040 NM_004336 BUB1 tgcccacttattccagaatggcagtgtattagtaggagagctctacagctatggaacatt 3041 NM_004343 CALR tggacggagacgggtggacttcccgctggatcgaatccaaacacaagtcagattttggca 3042 NM_004355 CD74 ccatagactggaaggtctttgagagctggatgcaccattggctcctgtttgaaatgagca 3043 NM_004374 COX6C tcacagaatttcttcaggttgaattacctagaagtttgtcactgacttgtgttcctgaac 3044 NM_004380 CREBBP ccaagaatacggctctgattgcccccctccaaacacgaggcgtgtgtacatttcttatct 3045 NM_004385 CSPG2 caatctatttaccaggacctgatcgctgcaaaatgaacccgtgccttaacggaggcacct 3046 NM_004413 DPEP1 tgcagacttctttcgggacgaggcagagaggatcatgagggactcccctgtcattgatgg 3047 NM_004425 ECM1 gtgtgccaaacttgtggtaaggttgggttcttgatgccggggggtgtcctttaaccccag 3048 NM_004430 EGR3 gccacagcttgcagcatggtcttgactgaatgtactgttcctgttagcgttacttctcct 3049 NM_004448 ERBB2 agtgttgagggaaaacacatcccccaaagccaacaaagaaatcttagacgaagcatacgt 3050 NM_004449 ERG ggactcaggacatttggggactgtgtacaatgagttatggagactcgagggttcatgcag 3051 NM_004454 ETV5 ttcgcagggataaggggtgcactttatagctatggaaacatgagattctcctctattgga 3052 NM_004475 FLOT2 tcagaggatttccctagagattatgacgttgcagccccgctgcgaggacgtagagacggc 3053 NM_004494 HDGF tcttcctactggtctctctatgcctctctacagtctcgtctcttttaccctggcccctct 3054 NM_004501 HNRPU agtggagggggtaagctaaatcatagtttctgacaataactgggaaggttttttcttaaa 3055 NM_004508 IDI1 tcatccattaagcaatccagccgagcttgaggaaagtgacgcccttggagtgaggcgagc 3056 NM_004513 IL16 ttaagaggcaggctcggatggactatagctttgataccacagccgaagacccttgggtta 3057 NM_004526 MCM2 ccatctatcagaactaccagcgtatccgaatccaggagagtccaggcaaagtggcggctg 3058 NM_004530 MMP2 agtgatggttcccctgttcactctacttagcatgtccctaccgagtctcttctccactgg 3059 NM_004557 NOTCH4 ggcatatgggatgtaagatgttctttcctatatatggtttccaaagggtgcccctatgat 3060 NM_004583 RAB5C gcaccttcctgggcatactctgcgttaaggtggacgttttgaccgagtcgatgcgccgtt 3061 NM_004615 TM4SF2 ctgcttattttaatcacagaagccttaaggggactgatagttgtatgaagggtaggagct 3062 NM_004624 VIPR1 tctgccagaagatcccctcaggactgcaacaggcttgtgcaacaataaatgttggcttgg 3063 NM_004633 IL1R2 gattttaaatgtgttgtccataataccctgagttttcagacactacgcaccacagtcaag 3064 NM_004642 CDK2AP1 gactgtaagtagatctcagttctgcgtttattgtaagttgataaaaacatctggaagaaa 3065 NM_004688 NMI gcacctacatcattgcttctacgcttgacgtggctctgagctcccaatctcctgggacag 3066 NM_004689 MTA1 agatgttggaatatatggtccaatgaagcacatccctcgcgcccgacccgccctggcagt 3067 NM_004706 ARHGEF1 acggcccttcggaaagtgctgtccctgaagcagcttctgtttccggcggaggaagacaat 3068 NM_004725 BUB3 gactgtgccaattccatcggtaccccacgagcatcgcatcacttgccttcagtaatgatg 3069 NM_004815 PARG1 gttccaactctatttttgatccggattacatcaaggagttggtgaatgatatcaggaagt 3070 NM_004827 ABCG2 gtaggttagtagcccttcagtcttaatactttatgatgctatggtttgccattatttaat 3071 NM_004867 ITM2A tgttgagaccaagatctgtcaagagtaagaggcaacagatagagtgtccttggtaataag 3072 NM_004924 ACTN4 tcataatgaagacatagccgattctctgcccgggccccttgctgatgctcctccgggtct 3073 NM_004936 CDKN2B gacaggtttagctgtttcatcagcagcctaatatatactgttaaatttgttaaggatttc 3074 NM_004938 DAPK1 ctatgatgttaaccaacccaacaagcacgggacacctccattactcattgctgctggctg 3075 NM_004941 DHX8 aagtccacagtccgagtgcagaaggccatctgcagtgggttcttccgtaatgctgccaag 3076 NM_004972 JAK2 agaaagcaggtaatcagactggactgtatgtacttcgatgcagtcctaaggactttaata 3077 NM_004994 MMP9 tatttctgccaggaccgcttctactggcgcgtgagttcccggagtgagttgaaccaggtg 3078 NM_004997 MYBPH gcagaaggcagacaaaaagacagggcaatggttcacagtgctggagcgctaccaccca ac 3079 NM_005012 ROR1 taatcatatctgacacttacatagtactccagcttgaatagtactcatgtgcctccgggt 3080 NM_005080 XBP1 ttttaggtcctttagtttgcttctgtaagcaacgggaacacctgctgagggggctctttc 3081 NM_005084 PLA2G7 gacatagattcaaatgcagctattgatcttagcaacaaagcttcattagcattcttacaa 3082 NM_005085 NUP214 ggaacgctcgagtctgcttgctgtgtccaacaaatatggtctggtcttcgctggtggagc 3083 NM_005098 MSC acgtgagatccgcgtcgggacagggttttaagtgacaaagaagggcgagtggcttctctg 3084 NM_005104 BRD2 cgccattacaatccacctccatccgcttggaaatggccttcgtcccggcctatgactggt 3085 NM_005123 NR1H4 ttgaagctatgttccttcgttcagctgagattttcaataagaaacttccgtctgggcatt 3086 NM_005157 ABL1 ctcttgaactgggcgaatgtcttatttaattaccgtgagtgacatagcctcatgttctgt 3087 NM_005161 AGTRL1 ctgccagagagaccgtgaggatgaaattaatagtggggcctttgtgagctagaggctggg 3088 NM_005178 BCL3 aggtgggccgtaacgggcacggatcacgatgtaaattattaagcattttggttggatttc 3089 NM_005187 CBFA2T3 atagtctttgcagaggtccaaatgatattcatgatggtaataaacgagatgtttgccaaa 3090 NM_005192 CDKN3 ttttatataccacgccacccatggggggtcttaacacgtgggggggcacccgataagcag 3091 NM_005197 CHES1 atatacatcaacacttttgctatataacctaagtgataaccctcttttagttacctgcca 3092 NM_005215 DCC gtgataggcttactcatcaaatcatggatctcaaccttgatactatgtattactttcgaa 3093 NM_005225 E2F1 taaaggttttttctgattgaagctttaatggagcgttatttatttatcgaggcctctttg 3094 NM_005230 ELK3 atgttgccaaacgctgccagtatttcatccgcctcacccttctcatctcggtccccgtcc 3095 NM_005239 ETS2 gcctaacagttatggaaactacagtccttataaaccattggcatggtaataaacagatct 3096 NM_005245 FAT tcaattatagatggcaaccaaggaagctcgttcacaattgaccccgtcaggggagaagtc 3097 NM_005246 FER agaaagtttgcaagtaatgttgaaaacgttagcggaagaacttatgcaaacacagcagat 3098 NM_005248 FGR aagggccgaatcccctacccaggcatgaataaacgggaagtgttggaacaggtggagc ag 3099 NM_005252 FOS ctgatcatgcattgttgaggtggtctgaatgttctgacattaacagttttccatgaaaac 3100 NM_005263 GFI1 ccttcccatttccagccctaatctacagacaggaatgcccttcaggtttcttccctcccc 3101 NM_005318 H1F0 cctctggatttttgttcctcctgtacaagaggtgtctttgcttggtttggtggggctgcg 3102 NM_005334 HCFC1 tattgtagagtaacccctgtgactcaatattaccatagtgcgatgtcgttttgtgctatt 3103 NM_005335 HCLS1 ctctgggcttcccagtttgtttacccgggaaagtacgtctagattgtgtggtttgcctca 3104 NM_005339 HIP2 gggtctattctgagccgttaacttcctgtaaggggaaaatgggtgggttaccagaaatac 3105 NM_005340 HINT1 ccatgttcttggaggtcggcaaatgcattggcctcctggttaagcacgttttggggataa 3106 NM_005356 LCK acatgtgacacatatgcaccttgtgtctgtacacgtgtcctgtagttgcgtggactctgc 3107 NM_005375 MYB acccccctcattggtcacaaattgactgttacaacaccatttcatagagaccagactgtg 3108 NM_005385 NKTR aaatgggtcggatagtaagcagtacaatatcatgtgtccctgtaaggaaggttcccaagt 3109 NM_005424 TIE1 atggagcagcctcgaaactgtgacgatgaagtgtacgagctgatgcgtcagtgctggcgg 3110 NM_005427 TP73 gtccaaactgcatcgagtatttcacctcccaagggttacagagcatttaccacctgcaga 3111 NM_005439 MLF2 attcaccgtcagcatatgagccgaatgctgtccggtggctttggatatagccccttcctc 3112 NM_005494 DNAJB6 gcattgtagcacgcgctgtatggttgtgcgttgtagcgtgcgctgtatagttgtgatgcc 3113 NM_005504 BCAT1 gtaatctactgttgggatggtaagaattgatgtaggctgtggtgtaagaatgaattaaaa 3114 NM_005521 TLX1 cacacatggaaacccataggtccacacacaggtggtgttactgtccctcctggtgtcacc 3115 NM_005529 HSPG2 ggtctcaccagctgattctggagaatatgtgtgccgtgtggagaatggatcgggccccaa 3116 NM_005533 IFI35 ctgactttctcgcggcggtagacagcgcctcgcagttgctgtcgacatatttgttcctac 3117 NM_005556 KRT7 actctcaaacaccagcccctctatcggcagcctgtctgaagttctttgaagcccctgtca 3118 NM_005563 STMN1 cacacacacccgcccgaagagcctcagtgcttacactaaggagtcgtcttctatgcaata 3119 NM_005566 LDHA acacaagattaataccatccagcatcaggatatagctgtggattttacaaaccattctta 3120 NM_005572 LMNA gtgcgtgaggagtttaaggagctgaaagcgcgcaataccaagaaggagggtgacctgata 3121 NM_005583 LYL1 catccttttgttaattcttcaggggcccgttcccgactggcgccgttcgtttccgcccat 3122 NM_005589 ALDH6A1 cctagtgtaacaatgaaaccagatttctcacttgctcttcatacttctattttgaggtaa 3123 NM_005608 PTPRCAP tttttaatcccgccaacgcacaatctccggaggaatgcccacgagctctcgcgttggtgg 3124 NM_005621 S100A12 atgctaatcaagatgaacaggtcgactttcaagaattcatatccctggtagccattgcgc 3125 NM_005651 TDO2 gatgctctgatttaattctagaaacaatttgattacctcttgtttgtgacaagactaagc 3126 NM_005654 NR2F1 agacaggagcagcccacccagcagaaatacaatccgagctacaaagcatgggaaaaa gag 3127 NM_005671 D8S2298E gaagaagcttcaaagctcttggaggctttaaagttctttctgttgggtgtgcattacagt 3128 NM_005687 FARSLB aaatacttaattgagctactagtttctctattgtcccagggagatattagacctctcttt 3129 NM_005730 CTDSP2 acttgccccagagaagctactcggccaaacctagccagggtctgttcttgtggaccagag 3130 NM_005731 ARPC2 gtgtacgggagtttcttggtaaatccagaatcaggatacaatgtctctttgctatatgac 3131 NM_005738 ARL4A taggctatttagtcccatagtagttcagatctgcttagatgtgacaggcattgaaggctg 3132 NM_005761 PLXNC1 tgcagccgaaactcatgctgagacgcacggagtccgtcgtcgaaaaactcctcacaaact 3133 NM_005767 P2RY5 gaggaagtgcacccgccgtttttgttcagtctacccactctcagggtaacaatgcctcag 3134 NM_005781 TNK2 gatgcgagcactacctcagaatgacgaccattacgtcatgcaggaacatcgcaaggtgcc 3135 NM_005794 DHRS2 ccagagtgtcaggacatgtgtgacttagcccagattcagactttagtcacaagcaggatc 3136 NM_005808 CTDSPL atatttcatgggaatcgaacctagggatagtgctccacttctgacgatggagtgaagaca 3137 NM_005809 PRDX2 aacttaccgatcatcgcacgccggagttcgatcacgagaccgacggggaactgtcgatct 3138 NM_005826 HNRPR caggaagccgtgaaactgtgtgacagctatgaaattcgccctggtaaacaccttggagtg 3139 NM_005835 SLC17A2 ataacgcagcgtgtgagtctgagcattgcgatcatcgccatggtgaacaccactcagcag 3140 NM_005845 ABCC4 tggttacaaacacttccaatggacagccctcgaccttaactattttcgagacagcactgt 3141 NM_005870 SAP18 gtatgatacctgtacttaagcatcactcaagggtaagtgttctaggaaggttgatttagc 3142 NM_005895 GOLGA3 tccccacaccgtgtgtcacaacaggctagggcacttcacgatgtcactacttgtttttct 3143 NM_005900 SMAD1 actcaaatgggttcacctcataatcctatttcatctgtatcttaaatggccccaggcatc 3144 NM_005902 SMAD3 gctgtctaccagttgacccgaatgtgcaccatccgcatgagcttcgtcaaaggctgggga 3145 NM_005907 MAN1A1 ctatcgagactcatttgatccgcaagtctagcagcggactaacttatatcgcagagtgga 3146 NM_005911 MAT2A tggcagaactacgccgtaatggcactttgccttggttacgccctgattctaaaactcaag 3147 NM_005923 MAP3K5 gaattcggcagcgagtagataatatcgaagtcttgacagcagatattgtcataaatctgt 3148 NM_005933 MLL ctgcttcagcccgattgttttcgccactccattctggaacaaggtttgatatgcacaaaa 3149 NM_005936 MLLT4 agcttaccaacttgagcggcatcgaatagaggcagctatggaccgaaagtctgatagtga 3150 NM_005944 CD200 gggaccacgtctgttaccagcatcctccatatcaaagaccctaagaatcaggtggggaag 3151 NM_005954 MT3 gtttttcaccggggcgtggctaccctgtcgtgacgcgtttccgcgtattgtcccctataa 3152 NM_005956 MTHFD1 agcaaaaaggtgtccctacaggcttcattctgcccattcgcgacatccgcgccagcgttg 3153 NM_005957 MTHFR gtttctccatcagcttatgggatccttgtctttactgacaagaatggaatagaaatgtaa 3154 NM_005965 MYLK aaccaggattcttatttgtgctgttatagaatatcagctctgaacgtgtggtaaagattt 3155 NM_006005 WFS1 tgacatgggtgtgccaggctagactaggaggttccggtgtctggaaaagcactttacaga 3156 NM_006017 PROM1 tcttcacgcagagattttcatctattatactttatcaaagattggccatgttccacttgg 3157 NM_006038 SPATA2 cgtgatgccacgtaacttaccctatggacaaaagcaggaatgactaacacatcctaggag 3158 NM_006060 ZNFN1A1 gattctaatcccaacaagcaagggtctccttcaagattaatgctatcaatcattaaggtc 3159 NM_006079 CITED2 gatgtgggccaaactgttctggatcaggaaagtcatactgttcactttcaagttggctgt 3160 NM_006082 K-ALPHA-1 gccatggtaaatacatggcttgctgcctgttgtaccgtggtgacgtggttcccaaagatg 3161 NM_006084 ISGF3G cctctttgtgataattctcagtagttgtccgtgataatcgtgtcctgaaaatcctcgcac 3162 NM_006098 GNB2L1 gtggaagacagcgtcatggaaggagcacttagccagcgtctctaacgtaaaatggcaaac 3163 NM_006101 KNTC2 tttggaaagttgagtataaacaaaccgacatctgaaagaaaagtctcgctatttggcaaa 3164 NM_006113 VAV3 aacaagggacactcaaactaccagagaaacggaccaatggactgcgaagaactcctaa ac 3165 NM_006120 HLA-DMA cattctttggtgtcccttccccttatgattttactttccacagtgaatggcatttatttt 3166 NM_006152 LRMP tttcctctttttgcctttatctccccaactaaaatacaatggggaagaagtctgcctatg 3167 NM_006184 NUCB1 cccctaccttttgtggaaccagtgatgcctcaaagacagtgtcccctccacagctgggtg 3168 NM_006185 NUMA1 tgggcctggccagtcttcctcttagcctctggatctagaagggaccataagaggagtagg 3169 NM_006187 OAS3 cttaaacagcatggcgctggtacgtaaatagaccaatgcagttaggtggctctttccaag 3170 NM_006190 ORC2L gatttttaccagcagtgtcgggaggcattcctcgtcaatagtgatctgacactccgggcc 3171 NM_006191 PA2G4 caaaattcatcgtcttcaagcccctctttctagccttttctactactctctgcttggtca 3172 NM_006196 PCBP1 ttggatgcatctactcaaaccacccatgaactcaccattccaaataacttaattggctgc 3173 NM_006209 ENPP2 acccagaacaggcttgtgttgtaatagtgtgggccgctttgtctcaaatccgcagttcta 3174 NM_006216 SERPINE2 tggaacagcagtataaggtagtaggtcccggatgagtggtctacattccagtgcagagga 3175 NM_006230 POLD2 aaaagaaaatggcagttatttgtgggacagggctgtgttgagacttggcatgcttctttt 3176 NM_006231 POLE ccttcaagactttgatattcgagcaattctggattgggactactacattgagcggctggg 3177 NM_006235 POU2AF1 gaccccattaagcctaaaggtgatgggtcctcgcctaggcttagtgctaccatgtgggtt 3178 NM_006255 PRKCH gaattgcaggccactcatgtcagtgaccagatttgtggcttataaacattagcagtttat 3179 NM_006263 PSME1 taatgcccgcgcgcgctggtgggcgctttataataaagcggagcatttacacacacccgc 3180 NM_006268 DPF2 gtcttcacaccctgattcctcaagttttctgcttagtggcactgacattaagtagtgggg 3181 NM_006273 CCL7 agctttggagtttgggttttcttgtccaggtgcttcataaagtcctggacccacttctgt 3182 NM_006286 TFDP2 tcttagaattgagattgctacacggagcagtccttgacgatcgtgtttctgacgtttctc 3183 NM_006299 ZNF193 gttctactgttttcagtttcatattacccctatatgcatcaaagctgcaacttcccttgc 3184 NM_006301 MAP3K12 cctgtcttaaggcccagggggaggttaggagactgatagcatgtgatggctcaggctgaa 3185 NM_006302 GCS1 accctacttttgcctgtagcccatatgctagaggttggtgaccctgacgacttggctttc 3186 NM_006325 RAN gtccacatgggaccggaacatttaaggccaggccctagagggtgggtttaagcccccaaa 3187 NM_006329 FBLN5 catgcctggtattttcaaccataaaagaagtttcagttgtccttaaatttgtataacggt 3188 NM_006343 MERTK aaagtttgcctgacgttcggaaccaagcagacgttatttacgtcaatacacagttgctgg 3189 NM_006354 TADA3L gcacctcccctcgcaatcagaacaagcccttcagtgtgccgcatactaagtccctggaga 3190 NM_006355 TRIM38 gtgtgagagaagggttaagactggcttacaatgagatgcttcaaatgaaaagggaattat 3191 NM_006362 NXF1 tacgatacaacccctataccacccgacctaaccgtcggggtgatacttggcatgatcgag 3192 NM_006427 SIVA agcgctcggtgttcacactgaactgtggggtcgacgggaggggtgccttttacatgttct 3193 NM_006472 TXNIP tgtgtgaagttactcgtgtcaaagccgttaggatcctggcttgcggagtggctaaagtgc 3194 NM_006495 EVI2B acaatcatttccaccgcttgactcacttaacttgcccctgccaccagtagattttatgaa 3195 NM_006509 RELB aaggtggggggtaggttggttgttcagagtcttcccaataaagatgagtttttgagcctc 3196 NM_006534 NCOA3 caattttcctctccaaggaatgcacccacgagccaacatcatgagaccccggacaaacac 3197 NM_006559 KHDRBS1 agttaaagtcctaattggatttgtaccgtcctcccattttgttctcggaagattaaatgc 3198 NM_006565 CTCF gtgagctttgcagttacacgtgtccacggcgttcaaatttggatcgtcacatgaaaagcc 3199 NM_006579 EBP acttgtgtacctaagtgaccgccccacctgtggcttatacgtggcgtggcctctttcttc 3200 NM_006591 POLD3 ttggttggagttccatcttgcaagggataatacaaatcctatgatctctatgcccaatat 3201 NM_006602 TCFL5 tggcctgcagcaagccatcgtggttggctggaactagacgtgtgatttgaatgcaggagt 3202 NM_006676 USP20 actcattgctgattggaacaccaggaggaggttggatttctgccagtgggggatgtttct 3203 NM_006739 MCM5 ttgtgaagtgcggaaaaccagaggcgcagtcatgtcgggattcgacgatcctggcatttt 3204 NM_006747 SIPA1 agcctgggaacctctcagagaaggtctctcacttggagtccatgctcaggaagctgcagg 3205 NM_006748 SLA gccctgaatggaactactttaactaatccatagggacttctggtatgctttcctctcttt 3206 NM_006759 UGP2 agcaaaataggaaacggggtcgcataggacaatctctagtgcttgtaaatctaaggaaat 3207 NM_006762 LAPTM5 tcaacgctttaggctgagtcactcctcgggtctctccataattcagcccaacaatgcttg 3208 NM_006769 LMO4 accagaaggtctgctaaaaggtcagagtaatgcagaatgcgtgccttcatctcagatttg 3209 NM_006803 AP3M2 agattttccctcaaagaccatgatggtatcggactagttttcagacactgcctgttgctg 3210 NM_006820 IFI44L ctctataagtctagtgttcatggaggtagcattgaagatatggttgaaagatgcagccgt 3211 NM_006825 CKAP4 gggcagccctgtcggcaaggagcgtgcatactgcgtttgtgtaattgtttgctgtatctc 3212 NM_006845 KIF2C ggtctcgctatcaagatccaacgcagtaatggtttaattcacagtgccaatgtaaggact 3213 NM_006857 RY1 aatcgaaaaggtggattcaacagacctttggatttcattgcatgagaattgaagtgttga 3214 NM_006875 PIM2 aggggaaataaggcttgctgtttgttctcctggggcgctccctccaacttttgcagattc 3215 NM_006904 PRKDC ggcgtgatcgggatcgactttgggcatgcgtttggatccgctacacagtttctgccagtc 3216 NM_006910 RBBP6 tcttccaaagaggctagaacgtcagataaacatgattccactcgtgcttcctcaaataaa 3217 NM_006931 SLC2A3 cctagatctttcttgaagacttgaattagattacagcgatggggacacagaaggtcaccc 3218 NM_006932 SMTN agggggttgtagagcgactgcacataggggaaaacacacttggggtcaggctttttgccc 3219 NM_006937 SUMO2 atgcaagtatactagcagaaaaattgggccatagtatcgtggatttccaggtattttctg 3220 NM_006938 SNRPD1 gaaacgctgagtattcgaggaaataacattcggtattttattctaccagacagtttacct 3221 NM_006963 ZNF22 gatgctttatagtagatcacttaaatactggatcttttgctagtgtgaaaacattgggaa 3222 NM_006981 NR4A3 cttcagttatagtaactgactggtatattcattcagaagcgccataagtcagttgagtat 3223 NM_006994 BTN3A3 aaaatccagtacatggctcgtggagagaagtctttggcctatcatgaatggaaaatggcc 3224 NM_007022 CYB561D2 tatgctttcaggctacaaccactagcacggctgacgatggccctttctgcggagaccgag 3225 NM_007063 TBC1D8 gcccgattacttcaaccaccgagtgatcggggcacaagttgaccagtctgtcttcgagga 3226 NM_007065 CDC37 tgtctgtgtcttctatttggcaaacagcaatgatcttccaataaaagatttcagatgctc 3227 NM_007079 PTP4A3 gcaccttaaattattagaccccggggcagtcaggtgctccggacacccgaaggcaataaa 3228 NM_007117 TRH cgcttatgtcggtgtcccaacgtataaactatcacagtagcgctcatggctcgtaggttt 3229 NM_012092 ICOS tgagccagaggccactaggtattcttgctcccagaggctgaagtcaccctgggaatcaca 3230 NM_012120 CD2AP aatgggatgagggaagtttccagcagatttcaggctgttcttaaagtttttgttggtcat 3231 NM_012207 HNRPH3 caaaaacaccaacatacaagtcttgacaacagcatctggtctactagactttcttacaga 3232 NM_012223 MYO1B gaagcagtcacgaccattgctgcatattggcatgggacccaggtacgtagagaatacagg 3233 NM_012267 HSPBP1 ataaggggggcttacacagttgccctaatgcggctggaatccccattgggggtaggtgag 3234 NM_012317 LDOC1 caaccgcccgtttgatcgccgggcgtggtgattttttgtgagctccgcacacctactttc 3235 NM_012323 MAFF ttattgtgccaatatgccctccaaaccctcccaggattcaaagctaggtttggctgtctg 3236 NM_012334 MYO10 agaaatttgccttgtccctttgtgtacaaccatgcaaaactgtttgttggctcacagaag 3237 NM_012384 GMEB2 attaattcccaatcccccattccaccagggctgggagcccattcccagtgcttcccaagg 3238 NM_012417 PITPNC1 agtgtctgagatatccaggagattcattaggtcatcagcgatcaaaggttagcattttat 3239 NM_013282 UHRF1 tacaggggcaaacagatggaggacggccataccctcttcgactacgaggtccgcctgaat 3240 NM_013314 BLNK gcctgacctgatgaactgttaatatctggtgaggttgagttatcatgctactaatatttt 3241 NM_013416 NCF4 tgaacagttttcactggggttgagatcaaatcacagaacagtgtcaggggccctggaagg 3242 NM_014005 PCDHA6 atttgtctcccgccctaagtcctccagtctccttagagctagtacttactaagcatttac 3243 NM_014207 CD5 aaagctctttcatctatagtttggccaccatacagtggcctcaaagcaaccatggcctac 3244 NM_014232 VAMP2 tctattgtctttttaaatggcacaattttaagggtttgagggtacagtcccttaacctgc 3245 NM_014244 ADAMTS2 gaacaatacaccctctccgcccttggggtaatgtactttgtgatattgccacccgccccc 3246 NM_014298 QPRT aaaggatcaaccacatggggttctgcggtgataatgagcacatagtgaggggtcagcaaa 3247 NM_014345 ZNF318 tgaccactgttcctcagttgaccaccgcttctcagctgaccgctgttcctcagttgacca 3248 NM_014365 HSPB8 ggtgatatacaggtcttatatccccatatggaatttatccatcaaccacataaaaacaaa 3249 NM_014575 SCHIP1 accagcaattatgtgacctgctttcgatcataagactgtgttaagaccttctcctcagtg 3250 NM_014595 NT5C ccccggaaagatgattttgatcaagcacaggtaatcaggactgtcctcaggactttatgt 3251 NM_014614 PSME4 acatgaaagcacccagcgatgtgttgcagaaattatagctggtttaatcagaggttctaa 3252 NM_014624 S10OA6 tcgatcgcgatgtaagtcgcgagccggcaatcgcgtgtgcacatactcgcagatccttct 3253 NM_014667 VGLL4 tgtcagttacagtcctagatatacttactgctggtacagttgtactctaagattggtatt 3254 NM_014707 HDAC9 ctgcaagaaactgggctgctaaataaatgtgagcgaattcaaggtcgaaaagccagcctg 3255 NM_014724 ZNF305 aaatttgagactacctttatattctccaacacaagaccgtgtaggtgtcccttcagagag 3256 NM_014734 KIAA0247 catggagattagctgccgtctcaacgaggataaagacacccacacatcacttggggtccc 3257 NM_014735 PHF16 caaacatcaaaacagtgcttcagccaaattccatatgtaatgccattgggagagtattga 3258 NM_014780 CUL7 aaggaacccaggtcgagatgggacattgtgcggctcatcccacctcagacgtacctgcaa 3259 NM_014792 KIAA0125 acgggcacatacaggaaaacacggtaatgtaattagaatagtcagagaaaagtagccaga 3260 NM_014824 FCHSD2 aagttaaaagcccggcgatctgagtgtaattccaaagctacccacgcaaggaatgattat 3261 NM_014890 DOC1 cagacttttaaggcattccaaatcccagtcttcatgttgaactgggttaagcatttatta 3262 NM_014899 RHOBTB3 tataatattgggaccccataccgttagcccttgtatgtataccaacactgccaaagtaaa 3263 NM_014914 CENTG2 agcagtggagagctcggctcaaagtgcgaagttgtttagatttccacgttacacaaacac 3264 NM_015050 KIAA0082 ccaattctgggtatatcagtgtgtcttgcagaatcttggatcattaaagataaacatatt 3265 NM_015069 ZNF423 atggtctgcttttaaatgtgacttaatctgactgcagtaactagtacagttcaataaagg 3266 NM_015099 CAMTA2 atcccggtggacatgatctcactagccaagcagatcatcgaagccacaccggagcggatt 3267 NM_015147 KIAA0582 ggagaacaccccagttttagaggatgtccttgggaggatcgcaaagcagtctggtgagct 3268 NM_015149 RGL1 gggagaacctactcaagaggtgtctaaattcaaactttccaccaaggtagaaagcacggg 3269 NM_015158 ANKRD15 ctctttgtatttatggattcctttttaccgtgtcacatttactttggtcctctatgtatt 3270 NM_015166 MLC1 aagacatgaacgttttctcttcaccgccgtggggtgtattgactggtcccccatgggctg 3271 NM_015196 KIAA0922 ccaatgtctggactttttggttccatctgggccccgcaaagcgatgtgtatgaaaattgc 3272 NM_015210 KIAA0802 aaagccgaccagccaaataacaggacgtcaccagggatggcccagaaagggtacagt gag 3273 NM_015261 KIAA0056 agaggtgatcagttcagctgttgacgccttgcagaggctttgtagagcatctgcagagac 3274 NM_015335 THRAP2 ggcattttcagtgtactgccagtgcaggcgaccactgcctacacagatccacattaaatc 3275 NM_015436 RCHY1 gatgatccagccgactttgacactgttatctccgtaatagctttaccattaggctaggat 3276 NM_015458 MTMR9 ctgaaacctcaagagtgctgtaaggtacaggtttccatattgtgaacctgtgtacgcaca 3277 NM_015474 SAMHD1 ggaatggaacgacagtacttcagtccaaaatccaactcgcctccgagaagcatccaaaag 3278 NM_015528 RNF167 cttcccctgttatcctggtctaataaccccccacacatacacctctggtgacctatttgc 3279 NM_015568 PPP1R16B cagatctttgatatcgtactgaggtaacttccacgtagccccttgccacgcggcaccggt 3280 NM_015570 AUTS2 aacagccgtaacaggtcaaccttgtggagccatcgcgagttagagggtgaaagatggcag 3281 NM_015636 EIF2B4 catgttgcgctggctaactggcagaaccacgcatccctacggttgttgaatctagtctat 3282 NM_015670 SENP3 agcatattgccaagtatctacaggcagaggcggtaaagaaagaccgactggatttccacc 3283 NM_015710 GLTSCR2 agttgtagctgccatcagatgccggagactcgcccttcaataaaaaatctcttctagctg 3284 NM_015833 ADARB1 cggttaaaagcacagtctatggaacgctaatggagtcagcccctaaagctgtttgctttt 3285 NM_015855 WIT-1 cagatacgtaggcccatgaaattgatgaactgagagttgcttccagtcctgagcgcacca 3286 NM_015869 PPARG agcccaatatttgcttaccaaactggacatcattgatgatctggattcaggcagggtctg 3287 NM_015965 GRIM19 aaatcgaggacttcgaggctcgcatcgcgctgttgccactgttacaggcagaaaccgacc 3288 NM_016041 DERL2 ccaacaccgtcatacatatacctccgctacgcaaccttacctagttacgccccaattgta 3289 NM_016091 EIF3S6IP tccggcggtgctcgcaagcgaggcagccatgtcttatcccgctgatgattatgagtctga 3290 NM_016184 CLECSF6 tgtgtaagggaggtccatagaatttaggtggtctgtcaactattctacttatgagagaat 3291 NM_016195 MPHOSPH1 atatctgtttggattatagctaggatttggagaataagtgtgtacagatcacaaaacatg 3292 NM_016221 DCTN4 aaaggtagacctgctgttaatgatccagcattggtcacaatgtaccaactgctttctgca 3293 NM_016308 UMP- ttatatagtgttattcatggttcagctgatcttaacaaaattcgtagcagtggaaccttg CMPK 3294 NM_016343 CENPF ctgacatcccgacaggaaagactagcccatatatcctgcgaagaacaaccatggcaactc 3295 NM_016570 PTX1 aacctgagctttaggacctttaaaatctcagcatgccttttaagctagtacttttcctgt 3296 NM_016734 PAX5 gaagcatcaagcctggggtaattggaggatccaaaccaaaggtcgccacacccaaagtgg 3297 NM_017437 CPSF2 ttgcgtctttcttgtgactaaccaccctgatatagtattaaccactgtgttcaagagtaa 3298 NM_017448 LDHC ggcggaatggtgtctcagatgttgtgaaaattaacttgaattctgaggaggaggcccttt 3299 NM_017617 NOTCH1 aatgagtctgttgtgtgtcatgccagtgagggacgtcagacttggctcagctcggggagc 3300 NM_017771 PXK aaaattcaagtacacacatcagtgttggttactatgcagagaatgtcattgtgtatagtt 3301 NM_017787 C10orf26 tcttcaatgacaggcttggactagctgtggcccagacatcggccctgcccagaattgcca 3302 NM_017794 KIAA1797 acacatgcctcctaagagaggagtgcattgctttagtacccgggccagttgagactgaaa 3303 NM_018136 ASPM ggcagctgtgatttccctccagtctgcttatcgtggctggaaggttcggaaacagattag 3304 NM_018209 ARFGAP1 tgtgctcgtcccaccctagggactcagccacttgcagaacaggatgggaccgagatttca 3305 NM_018248 FLJ10858 ataagccctcttctaaggcatgtgatgcttgcttgacctcaaggcctattgattcagtgc 3306 NM_018462 c3orf10 cggagaatagagtacattgaagctcgggtgacaaaaggtgagacactcacctagaacagt 3307 NM_018664 SNFT aggggctgttgtgagcccattggtatagcaactagtggtgctgtctactgcaaagcaaat 3308 NM_018951 HOXA10 gtaagcggaataaactagagaagggagacattgtttggatttcctttatactgtgaagtt 3309 NM_019028 ZDHHC13 ggaagacaccatacaatcttggattcatgcagaacctggcagatttctttcagtgtggct 3310 NM_019071 ING3 taaccaagattgccctatagaatggttccattatggctgcgttggattgacagaggcacc 3311 NM_019102 HOXA5 agatcatagttccgtgagcgagcaattcagggactcggcgagcatgcactccggcaggta 3312 NM_019111 HLA-DRA ccaactatacttcgatcaccaatgtacctccagacgtaactgtgctcacaaacagccctg 3313 NM_019841 TRPV5 ctaccatttttgattaacatcgctatcactcttgaccttactcccggttggcctgggggc 3314 NM_019846 CCL28 aacacgaaacatacggccataaaactccttattagagagtctacagataaatctacagag 3315 NM_019857 CTPS2 cgttttccccgtactagatggttagggcgcatagtgccgaactacgctgctgctacagaa 3316 NM_020310 MNT tggctccacggtcatcgcccacacagctaccactcacgcttcagtcatccagactgtgaa 3317 NM_020368 SAS10 gagaatgcatctttgacagttatcttatttgtaaggcagcctataaaatagttctgaagt 3318 NM_020371 AVEN caggaccagccagtttacaagcatgtctcaagctagtgtgttccattatgctcacagcag 3319 NM_020631 KIAA0720 agcaccatgcattatgatgggcatgtccgcttcgaccttcccccacaaggctctgtgctg 3320 NM_020657 ZNF304 attcgaacattctagaggggacatccacaagtctcggtgcagttatgatggtgtgggatg 3321 NM_020841 OSBPL8 tggatccattactcaacccttacctagcagttatttgatcatccgagctacttcagagtc 3322 NM_020843 ZNF291 caagattaccttcttaatggacctcctgatacaccagttgacggtttatgttccagatga 3323 NM_020892 DTX2 tcagccacgatcctctggacagagatttgtggcgaagacctgacgagagactgtaaagga 3324 NM_020944 GBA2 aagacacctttcatcgacatgatcaattctgtacccctaagacagatttatggttgtccc 3325 NM_020956 PRX aggtgcagctgccgaaagtgtcagagattcggctgccggaaatgcaagtgccgaaggttc 3326 NM_020998 MST1 tctcctacccatacttggaggccccgctcagacggtcctgaaaacgtctgaaaggcggtt 3327 NM_021019 MYL6 aaggaccaggcacctatgaggattatgtcgaaggacttcgggtgtttgacaaggaaggaa 3328 NM_021038 MBNL1 cagacagacttgaggtatgtcgagagtaccaacgtggcaattgcaaccgaggagaaaatg 3329 NM_021071 DO cctttttgaccagtgtcatcatcttttccaaaagcagagtataaagaaatcttgtggctc 3330 NM_021103 TMSB10 ctctccgatttgtgtgtgcggcgttgtctttacttgtacgcctcccgtgagaccactctg 3331 NM_021111 RECK caaccctcgatgagaccatcaacaatctccatttccgttttcttggacatcaggattctc 3332 NM_021114 SPINK2 tcacccacctcactatactctcccttatcgcgcgtctatatggccccgatcacccttccg 3333 NM_021643 TRIB2 tggaagacgcctacattctgcggggagatgatgattccctctccgacaagcatggctgcc 3334 NM_021814 ELOVL5 acttatgtgtttgtggagatgttggtgtaaacctactgcactgctaattctataaaagta 3335 NM_021906 USP9X gaaaaactattcctaatcaacatggagtggagagtttattcactgtcttatctgcagaaa 3336 NM_021949 ATP2B3 ttcttctcactctctgtcgtagacacaccgataggaccaatggccaatagatattaaaag 3337 NM_021960 MCL1 tgatcctgttagcaggtggtaataccatgggtgctgtgacactaacagtcattgagaggt 3338 NM_022067 C14orf133 attttgcacaagaacaatgcccctgtgcagatattacaggagtatgtcaatctggtggaa 3339 NM_022127 SLC28A3 agtggatcatctggggaatgccatccccactgtagaaatgctgcctcaaaaatgttctgg 3340 NM_022161 BIRC7 gcaaacctggtcagagccagtgttccctccatgggacctaaagacagtgccaagtgcctg 3341 NM_022334 ITGB1BP1 ggagtccgtttttgaggtcacgcggctagtaattggagcctggtttagaaccaagtcagt 3342 NM_022366 TFB2M ccctggaagataggtagcaactagactgtcgtttttggtggagcggttcatttatttgga 3343 NM_022436 ABCG5 atgcagatgtccacacgaggggtcggagttacctgatcacatcgagagagtgctgggcag 3344 NM_022438 MAL aatgaagactttggatttattaaaaccaagttgtccctaaggaatcagatgtgggcatct 3345 NM_022469 GREM2 tacagaatgcaaacacgagcacactctcttcgaacccaattgtgggtgtagcaatgaaag 3346 NM_022549 FEZ1 cctggtatcacttgctcgctactttctagggtcttaatagtagtcaagaaaagggatctg 3347 NM_022716 PRRX1 ccagccatgcttttgtaacttgccaggtggacttgaccaactacattaccatgctgtgcc 3348 NM_024006 VKORC1 agctcccgcgactgctacgtgctcattagtgttcgtccgacgacgaccgtcatatgtcca 3349 NM_024319 C1orf35 taccagggatggcccctggcttggcctgcgaaggtgaacctgcccagatttatcagtaga 3350 NM_024408 NOTCH2 acagaccatatggatcgtcttccccgggatgtggctcgggatcgcatgcaccatgacatt 3351 NM_024424 WT1 tggaagtcgtttttcctaactaggactcaactatgaggggcgaggagccctttatgaaaa 3352 NM_024713 C15orf29 cagattattgcacgtctgtgatttgagaggtgagttatttaagaggccagttttcaggac 3353 NM_024728 C7orf10 ctctggtattaatgaatctagtgccttttaaatgtatcccacgttttgttccctaccatc 3354 NM_025263 PRR3 tggtggaaactcaagtgtgtctactttgtgagaactgggttgtgcacttaaaactggtgt 3355 NM_030660 ATXN3 catggaatgtaggtgtctgcttcacatcttttagtaggtatagcttgtcaaagatggtga 3356 NM_030674 SLC38A1 cagatgggtgatttaagtgagtcacaagtcacaaaactttgctattcatagttaatcaaa 3357 NM_030915 LBH aatgcctgttgtgagatgaacctcctgtaacttctatctgttcttttttgaggctcaggg 3358 NM_030926 ITM2C tgctaaccgttctcagccctgagccttggagaggagggctgtaacgccttcagtcagtct 3359 NM_030935 THG-1 cagcctggttcacaaatctccagaccccttcggagcagtagcagctcagaagttcagcct 3360 NM_031243 HNRPA2B1 caagacctcattcaattgatgggagagtagttgagccaaaacgtgctgtagcaagagagg 3361 NM_031423 CDCA1 tatttctaaacttgaaaactgctttggagaaataccacgacggtattgaaaaggcagcag 3362 NM_031966 CCNB1 tcttccagttatgcagcacctggctaagaatgtagtcatggtaaatcaaggacttacaaa 3363 NM_032121 DKFZp564K142 acaagttccgtcgccttgtgaaagccccaccgagaaattactccgttatcgtcatgttca 3364 NM_033238 PML accatgtgtgctgttttcagatgtgattgaggggtgttctgccctgcctccactgtcaca 3365 NM_033512 TSPYL5 ttgaggatgttcccaaagttttgtccaatcttatcattagtagattttataagccacaga 3366 NM_033554 HLA-DPA1 tacttggcgtcttagatcccccctcggagtagcggctcacgcaacacaaagtatagcaca 3367 NM_033642 FGF13 aatctgtgttccaaaagtggacatagcatgtacaggcagttttctgtcctgtgcacaaaa 3368 NM_057168 WNT16 gccttttcactgggagaatctggaaaaacctccataaggtatatagcaatctttgatctt 3369 NM_058195 CDKN2A atgtgtcacgatagatacatttcccgtatacttctgcgactatatctctctgtatttcta 3370 NM_080284 ABCA6 tctagttccactgtggaattcctttctggttgtacatttgctaggtagtgacaactaatg 3371 NM_080700 TREX2 gacatcagcaccctagaccagaagctgcgtctggtcacttccgacttccaccagctaatc 3372 NM_130439 MXI1 gttgtgtgttaatgttagactatccctttgtgagtgacactttaacagcattcactgctt 3373 NM_133259 LRPPRC aatccttagagagggtaaccaggaagttccgtttgacgtacctgagttgtggtatgaaga 3374 NM_133378 TTN cgagatgaatacgctccacccaaagccgaactggatgcccgattacacggtgatctggtt 3375 NM_138714 NFAT5 gtgagtttgtctgatgttctaccacaacgtggcgtctgataacagtgagggggggtgggg 3376 NM_144578 C14orf32 ggcactttcactgcctgtcactgatcagcagatactgacttgttgccattaagtgaactt 3377 NM_144628 TBC1D20 ccactcactaccttggcgtcgttttttgggtctgacttgtctcgtcaactgctggtctct 3378 NM_145698 ACBD5 ggatatagtgttcctgctttgtttaataagaacctcatttaaacttgacagctatggtat 3379 NM_145867 LTC4S gtcactagaactttaatgatagagactaggatgcggaagcgagcgcccctccccggggca 3380 NM_147180 PPP3R2 ccttgaactgagagcctgtatctggatttagcacttgaaagatctaactggatatttggg 3381 NM_152739 HOXA9 aatagttacctcaaggcctactgaccaaattgttgtgttgagatgatatttaactttttg 3382 NM_152788 EB-1 aacccaagatgcttgtgcaaaaatgcgggctaactgtcagaagtctacagagcaaatgaa 3383 NM_152827 SNX3 ttcctccaggcttgtaatacccttcacatggaagattaatgagggaaatctttatattct 3384 NM_152890 COL24A1 tttcacacccaggaacctaatcaacttccagtgattgaagtacaaaaacttcctcatctc 3385 NM_156038 CSF3R ttgtggcctataactcagccgggacctctcgtcccactccggtggtcttctcagaaagca 3386 NM_172020 POM121 tcaaccaagtatctgtgcaccccatggtcccttcaagttgacacttgaaattacccatca 3387 NM_173156 C1orf16 gagcccagggctaaaatcagtgctatctacaagccgaaatttaagcaacaactgtgacac 3388 NM_173216 SIAT1 gtacaatgaaggaatcctaattgtatgggacccatctgtataccactcagatatcccaaa 3389 NM_173609 C15orf21 aaggaccagccactttgaacgccttagaggcaaaaagagctttgtgagttgtaagaggaa 3390 NM_173852 KRTCAP2 ggatttctcctggactccatgtgcagatgcctagtatttccattctgaccgttgccctcc 3391 NM_175739 SERPINA9 agctaccgccaccaagttcatagtccgatcgaaggatggtccctcttacttcactgtctc 3392 NM_175744 RHOC caggggccttgtctctcactgcatttggtcaggggggcatgaataaaggctacaggctcc 3393 NM_178586 PPP2R5C tggaccccgttccgtaggcaataacgtgcgtccgcctcagcgcgagattaggagttcaaa 3394 NM_181311 TAZ gtgaacatgagttccgaattcctgcgtttcaagtggggaatcgggcgcctgattgctgag 3395 NM_181336 LEMD2 actttcagtctcgtcctgacacgattccaaaggtctgccatactcttcagaggagttcgg 3396 NM_181339 IL24 gagtatatgtaggaggtgggatatcacttccatgacataagtgctattgcagagccgtgg 3397 NM_181430 FOXK2 tatgtttgtatttggggtgtccctccggctctaggcggcctctgacctgctgtctactcc 3398 NM_181493 ITPA tgtcgtgtccatccttccttcgtctggctcgtgattcacttattcgccctccctactttg 3399 NM_181702 GEM atgcaggtcggggacgcatacctgattgtctactcaatcacagaccgagcgagcttcgag 3400 NM_182729 TXNRD1 cattcctgctactctacctgtatttctcagttgcagcactgagtggtcaaaatacatttc 3401 NM_182810 ATF4 ggaagaaaagggtcccctagttgaggatagtcaggagcgtcaatgtgcttgtacatagag 3402 NM_183395 CIAS1 gagccgaagtggggttcagataatgcacgtgtttcgaatcccactgtgatatgccaggaa 3403 NM_198232 RNASE1 cgcaacatgcaattatattaaactcggccaaaccctctgcgggataaaggggttttgttt 3404 NM_198400 NEDD4 ggtctggaagaaacatgtatcaagcaacacagccccttatcccagatagaaaagtgtctc 3405 NM_199335 FYB tgagctgtgtggtctgtccagctttcacacattgatatgtgaggctacatttgcatgtta 3406 NM_199423 WWP2 aagtggtgtccgcaaagcccaaggtgcataatcgtcaacctcgaattaactcctacgtgg 3407 NM_201592 GPM6A tatggaaattttgtctgaagatcagtggccatattactgtaggccctggttcatgttttc 3408 NM_201632 TCF7 aaagagaccgtctactccgccttcaatctgctcatgcattacccacccccctcgggagca 3409 NM_201998 SF1 cttgtaaagttgccgagggtaggttcatctccaggtttcgggattcccatccgtcctggc 3410 NM_212474 FN1 gggcaactctgtcaacgaaggcttgaaccaacctacggatgactcgtgctttgaccccta 3411 R14777 CYFIP2 ctgctgggccagcagcgtcgctttgacctgttcgacttctgttaccacctgctaaaagtg 3412 R56397 PIK3C3 gaaccagataaaactgtgaaaaaggttcaggataaattccgcttagacctgtcggatgaa 3413 R59027 GRP58 ctcattgaaactctttttgtggatttgatgaccttatggatattgccaaagtttaaggca 3414 R72151 GNL3 gctaaactgttctctgtataagttatggtatgcatgagctgtgtaaattttgtgaatatg 3415 R79128 MAP3K1 gtagcagcaatagtagtaatgctgttatacccagtgacgagacagtgttcaccccagtag 3416 R86893 C6orf110 tcgaagcccgcccgtgttacaacgtggctcgcctaatgttcctcgatgcagagaggaaga 3417 T07281 NRIP1 gcatacatccacagattcactttgtttatgcatatgtagatacaaggatgcacatataca 3418 T28925 ITGAL taatgattgacgtacttagcagctatctctcagtgaactgtgagggtaaaggctatactt 3419 U60115 FHL1 accgtgtagacacacgacatgcaagagttgcagcggctgctccaactcactgctcaccct 3420 U79271 AKT3 tttacattcatctggtttagacttaatatgccacaacgcaccacgaccttcccagggtga 3421 W04885 MYL4 tccgtgtaaccacatgcgcccaatgtccgtttgtctctcccgtgtgcgaaaaaacttgtg 3422 X66087 MYBL1 ggctcattgaacgatggtggtaatatggcgctaaaacatacaccactgaaaacactacca 3423 AK024272 ctttcacctcaagaggttgcgacaagctactccaatacccctgctgggatagtgtcacag 3424 AK025231 IGLC2 aaaatgtcaatggtgtgtctggctggctgatgggatttcacctaattttaatgtggcttt 3425 AL080190 ggctgaaccttatggacagtactgctgatttagtgatctgaccttgaattaggggtttca 3426 BU618233 ccaccatcagtgtatgagactgcctgattccctgtacattcattcctgtggctgctctaa

TABLE 23 70mer polynucleotide probes, according to one embodiment GenBank Accession SEQ No. for ID NO: Target gene Symbol 70mer 3427 AA594161 MYH11 atttcaccagatccatcctcactcctcgtatcaaggttgggcgagatgtggtacagaaagct cagacaaa 3428 AA766908 MME aatcgagtgagacaaaattttagtccaaataacaagtaccaaagttttatcaagtttgggtct gtgctgc 3429 AB014540 SWAP70 gctttggctaagatagatacttgtgaatcaaagatagcacagaaatgaactaagtatatccc atttggaa 3430 AF196185 PARD3 tggttctgtttcttaatcacgtgcggcggtgtctaagtggtgttaccagtgtacgcgcagtga ccttgga 3431 AI597616 MRPL33 cctgggatggaggaactgagtttgcaaatcagctccatcttcatatcaaggaatagtaaaat aagagaaa 3432 AI634809 ARID5B ccctgttcttcaaagcttagctggtcatatttctacttgcttccttttagcttctgccttgcttgtttta 3433 AI672553 AKAP12 atatgctggactgcattcacacatggcatgaaataagtcaggttctttacaaatggtattttga tagata 3434 AI809213 RGS13 ctctcctttcttcgaatgattcccatagaggatcactgtcagagctcgcctttcttctatctgcc ttata 3435 AK022231 STAT1 aggttaacgttcgcactctgtgtatataacctcgacagtcttggcacctaacgtgctgtgcgt agctgct 3436 AK022293 CTSD aggcacccctagctcttgggatgtttgtatccaactccgggcaatgtggggctacaaaggc ccctggctt 3437 AK055652 C3orf6 tgtataacatgataatgatgcctggtgtattgaaatcctcaataaatactgccaagtgtggatc agttgg 3438 AL080130 FLJ14001 ccacagtggtttctctctagtcagtaacaaaatttcattatggtttcaggcattatatggtggta aataa 3439 AL833316 MIR gcacagttagatgcaatgtttatagaaattgattgttaaaccaaatttacactggcatgtgtgg tgtagt 3440 AW291384 STS-1 atgcctcatagtttacctcagcggagtggtggtttccgagattacgagaaagatgctcccat cactgtgt 3441 BG993697 SMYD3 cttcactccctttcttgaaaacctcctgtagttcctgttgtgtacgggataaaggtgcttaccat ggggc 3442 BI769730 HLA-DRB1 aggtataaaggtcccttacgatacctcgctgtcccgtcatcgtcaatatctaggacggcata gtgaccac 3443 BQ632574 RASA1 gttgaccgctcctccaactaaccagtggtatcacggaaaacttgacagaacgatagcaga agaacgcctc 3444 BX504817 SFRS7 aacttgggaatactggtctgcatcaagtttattcggtagtttgaccgctagtatgttggaagtt atttgg 3445 H53164 IRF8 tgggatgccttactttgcacttaatttaataagggcattctcggaggagtagacgtttaatacg aagtgg 3446 H57732 TGFBR2 ttcctgagagcatgagggcccctagacagagtacaaggtgtaattcagacagccagcca gaaaaagaatt 3447 L29376 3.8-1 ggttgcaggttgtttaaccttatatgtacagtttcacatatgtataaaaacagtagtttggggg cctctt 3448 M80899 AHNAK ctcctgatttggatattgagggaccagaaggaaagttgaaaggctccaaatttaagatgcc caagttgaa 3449 NM_000038 APC tcgttcgattgccagctccgttcagagtgaaccatgcagtggaatggtaagtggcattataa gccccagt 3450 NM_000043 FAS cctcctgaccaccggggcttttcgtgagctcgtctctgatctcgcgcaagagtgacacaca ggtgttcaa 3451 NM_000061 BTK atgtaaatagccgcacaaaggggtccaacagctctttgagtaggcatttggtagagcttgg gggtgtgtg 3452 NM_000075 CDK4 caggtaccaatagatgggacgacctcggtaaacacatgattcctgctcggaattgcctaac cttccaaac 3453 NM_000109 DMD gacatcaagtgtaattagcttttggagagtgggctgacatcaagtgtaattagcttttggaga gtgggtt 3454 NM_000189 HK2 tctcatcgatttcaccaagcgtggactactcttccgaggccgcatctcagagcggctcaag acaaggggc 3455 NM_000237 LPL agagatgatcgtgcctataaatagtaggaccaatgttgtgattaacatcatcaggcttggaat gaattct 3456 NM_000269 NME1 cacgggatgcatagcgtcgcacgcgatcgggtcgcgtctactaatgcttcgatatctatac gtcgcacac 3457 NM_000271 NPC1 ttctagccctctcgcagggcatcctgactgaactgtgtctaagggtcggtcggtttaccact ggacgggt 3458 NM_000295 SERPINA1 ggatgaggttgagtcataccaaatagtgatttcgatagttcaaaatggtgaaattagcaattc tacatga 3459 NM_000313 PROS1 aggaatcttcttcttggcagctgcagtctgtcaggatgagatatcagattaggttggataggt ggggaaa 3460 NM_000397 CYBB tagtgacagtattgacatctgagcatactccagtttactaatacagcagggtaactgggcca gatgttct 3461 NM_000405 GM2A ccccacggtcccgctttaaggtccataaatatccctaaggaaaaatccaccgtggtacattc agtcctct 3462 NM_000424 KRT5 gaagggataaaaagggggcatcaccgttcctgggtaacagagccaccttctgcgtcctgc tgagctctgt 3463 NM_000483 APOC2 agaagacatacctgcccgctgtagatgagaaactcagggacttgtacagcaaaagcaca gcagccatgag 3464 NM_000576 IL1B tgcccgtcttcctgggagggaccaaaggcggccaggatataactgacttcaccatgcaatt tgtgtcttc 3465 NM_000579 CCR5 ctaaaaccatcatagtacaggtaaggtgagggaatagtaagtggtgagaactactcaggg aatgaaggtg 3466 NM_000584 IL8 gtgctgtgttgaattacggaataatgagttagaactattaaaacagccaaaactccacagtc aatattag 3467 NM_000585 IL15 tttctcttggagttacaagttatttcacttgagtccggagatgcaagtattcatgatacagtaga aaatc 3468 NM_000600 IL6 gcaaagaggcactggcagaaaacaacctgaaccttccaaagatggctgaaaaagatgg atgcttccaatc 3469 NM_000626 CD79B acagccacctatgaggacatagtgacgctgcggacaggggaagtgaagtggtctgtagg tgagcacccag 3470 NM_000627 LTBP1 aagtcctctgaagacaatgagaggatttaggatgagcccgataggtgtggcagaccaaat ggacatttct 3471 NM_000633 BCL2 gaggtggctgatattctgcaacactgtacacataaaaaatacggtaaggatactttacatgg ttaaggta 3472 NM_000655 SELL aaatttcatctcaggcctccctcaaccccaccacttcttttataactagtcctttactaatccaa cccat 3473 NM_000713 BLVRB catgacggcccggataacagcgacaatcgaacgctgaccgcttagaccttcgtgagtag ctcggtgtcgt 3474 NM_000785 CYP27B1 tttgtcttgcccctaggaaggtgaatctgccctagcctggtttacggtttcttataactctccttt gctc 3475 NM_000788 DCK tccctggtgcctctcacttcgttggtgaccagtttcttaaactgaaagctttaatgttacatagt aaatg 3476 NM_000853 GSTT1 aaagagaatataggcccgtggcagatacagaggttttctgcccttttggcctgcatgccca acctttggg 3477 NM_000877 IL1R1 agaaaatgccagaatcgattaaattcattaagcagaaacatggggctatccgctggtcagg ggactttac 3478 NM_000917 P4HA1 cctaccactgcagacgaatgtcagcgtcacataaaaagagcatgtaggatgggacatatt gggatgtatt 3479 NM_000927 ABCB1 atcctcaccaagcggctccgatacatggttttccgatccatgctcagacaggatgtgagttg gtttgatg 3480 NM_001067 TOP2A atcagataggagcagtgacgaaagtaattttgatgtccctccacgagaaacagagccacg gagagcagca 3481 NM_001068 TOP2B tcactggtgtcaagatgtatgagaaggcatatatatagtgaatttcacttcttaacttgttctca agtgt 3482 NM_001110 ADAM10 gacatgtatttcttacgtacactgtacttctgtgtgcaattgtaaacagaaattgcaatatggat gtttc 3483 NM_001154 ANXA5 cgtgtatgtgttggtcatgagcatgctagtatgaataaggcaatgtgttaagcactggcatac aaatgca 3484 NM_001166 BIRC2 attcggaagaacagaatggctctctttcaacaattgacatgtgtgcttcctatcctggataatc ttttaa 3485 NM_001196 BID aaacgaagttgaaaaagtcaagcccctgtgtactggggccggacttcccatcatttgagtg cagcacttt 3486 NM_001230 CASP10 tctgttaattcctggaactgtattttgaatccttaaaggtgagccctcatagggagatccaaa gtcctgt 3487 NM_001238 CCNE1 tccacattatcagttgacagtgtacaatgcctttgatgaactgttttgtaagtgctgctatatcta tcca 3488 NM_001242 TNFRSF7 ttgtcaccatcaggcaaggcacctgaattcccaccgcagagagtgttgtggccgtgagga cttttctgtc 3489 NM_001254 CDC6 ggcactcccaagggcgttggggtcataaggagactataactctacagattgtgaatatattt attttcaa 3490 NM_001350 DAXX tatgtgagctgaaagactgctcttcactgaccggccgtgtcatagagcagcgcatccccta ccgtggcac 3491 NM_001425 EMP3 tgttgtgcgtgttatagatcttgttcccccccgcacctttcccgccgcgttttggcttcttccct ctgtt 3492 NM_001552 IGFBP4 ggtagcagatggagtaatggtcacgaggtccagacccactcccaaagctcagacttgcc aggctcccttt 3493 NM_001558 IL10RA tactcttaggtgccagtctggtaactgaactccctctggaggcaggcttgagggaggattc ctcagggtt 3494 NM_001618 PARP1 aagttgctgatgggtagtacctgtactaaaccacctcagaaaggattttacagaaacgtgtt aaaggttt 3495 NM_001621 AHR tccacagtcagccataataactcctcagacatgttatgctggggccgtgtcgatgtatcagt gccagcca 3496 NM_001663 ARF6 gatgtagttaaattgaacaataaccattggtgactggagcaggtaattatagcctgcagaaa aaattatc 3497 NM_001706 BCL6 tttttcacggaagttttcaatgatgggcgagcgtgcaccatccctttttgaagtgtaggcaga cacaggg 3498 NM_001760 CCND3 gtctagagagggaggcaagccctgttgacacaggtctttcctaaggctgcaaggtttaggc tggtggccc 3499 NM_001762 CCT6A aagaacaggcagaggtaaaaagatgatggaaggtgtggtgactaagggccacggttatt gggtgaaattt 3500 NM_001770 CD19 ttgttgccccgggccacagctcaagacgctggaaagtattattgtcaccgtggcaacctga ccatgtcat 3501 NM_001771 CD22 ggctcagagccagtctttttggtgagggtaaccccaaacctccaaaactcctgcccctgttc tcttccac 3502 NM_001779 CD58 caaagaacaagcattagttttggctgtcatcaacttattatatgactaggtgcttgctttttttgt cagt 3503 NM_001781 CD69 gttggaaaatgtgcaatatgtgatgtggcaaatctctattaggaaatattctgtaatcttcaga cctaga 3504 NM_001782 CD72 aattgtcctcacctaatccagtacctccttacgctttagtcagtcaaatcttgtatttcagcctgt gatg 3505 NM_001826 CKS1B tccccgttataaccgcaccgatacccgcctccgctaatcggatgaaacccctgcacactat tgtcagtaa 3506 NM_001827 CKS2 ttattttatcatcgcgcgaccagctaaacactcctgcggtcgtatggtcgacaacaatcaca cataaaat 3507 NM_001831 CLU ggtaagtattttagcatggctgtcaaggaaattcagagtaaagtcagtgtgattcacttaatg atataca 3508 NM_001852 COL9A2 gtcgaagcgctgaaggaatagggcggctttccttccagcgagcatcattcggctgttacca aaacaaaca 3509 NM_001853 COL9A3 ataaaattcaacgtgaggaagcaagtgacaaggacgcccgaagcacagtggacggtcat gaaggagcggg 3510 NM_001877 CR2 atggctctaaaagttttgccctttttaaggaggcactaaaaagagctgtcctggtatctagac ccatctt 3511 NM_001888 CRYM cttaaatgctgagatcctcatttatgtttgtagttggaaagcaaagctaggtagccatttcttct gttct 3512 NM_001894 CSNK1E ctctgcaaaggctatccctccgaattctcaacatacctcaacttctgccgctccctgcggttt gacgaca 3513 NM_001951 E2F5 gacaaaagaaataccagatcaatctaaagagtcattcaggacctatccatgtgctgcttata aataaaga 3514 NM_001967 EIF4A2 ggctcgtggccggaacccgtttcttgcggaggaattttctcgccgtgcttcggtcagctaca aaattgtg 3515 NM_002002 FCER2 accaagcatgccagccacaccggctcctggattggccttcggaacttggacctgaaggg ggagtttatct 3516 NM_002051 GATA3 tttttaacatcgacggtcaaggcaaccacgtcccgccctactacggaaactcggtcaggg ccacggtgca 3517 NM_002095 GTF2E2 tcctggttcctttcttcctcgtttgttactttagagcaagtttgcccatagtcttgaatgcaatattt gt 3518 NM_002101 GYPC cccatctgcagtgagtaggaagaggtcccctcaacagaggtgagaggttgggccaagtc aagtcagtttg 3519 NM_002105 H2AFX cttgattggtcacgatccccgcctacccaccaatccttaacgcgcctcaccggaccttaac attccaccc 3520 NM_002120 HLA-DOB agctaagggctcagaaaggatatgtgaggacgcagatgtctggtaatgaggtctcaagag ctgttctgct 3521 NM_002122 HLA-DQA1 caaagacatgcctggggtaagccacccggctacctaattcctcagtaacctccatctaaaa tctccaagg 3522 NM_002189 IL15RA gttgaacaaggccacgaatgtcgcccactggacaacccccagtctcaaatgcattagaga ccctgccctg 3523 NM_002211 ITGB1 tttgagttgcccatcttgtttcacactagtcacattcttgttttaagtgcctttagttttaacagttc ac 3524 NM_002217 ITIH3 ctgattgatggtgtccacactgactacattgtccccaacctgttttgagtagacacaccagct cctgttg 3525 NM_002250 KCNN4 gttaatgccactgggcacctttcagacacactttggctgatccccatcacattcctgaccatc ggctatg 3526 NM_002305 LGALS1 catggaggccatcaactacatggcggcggatggagacttcaagattaagtgcgtggccttt gagtgaagc 3527 NM_002350 LYN atctattctctccaaaaatgcacccaactagctctatgtttacaaatggacataggactcaaa gtttcag 3528 NM_002358 MAD2L1 ctcgcgcgtacatgttcgtgccagaacatgttacaccactcctacgatggcttgcccgattc gatgcccc 3529 NM_002426 MMP12 gactctactattaagtttgaaaatagttaccttcaaaggccaagagaattctatttgaagcatg ctctgt 3530 NM_002467 MYC cagaaatgtcctgagcaatcacctatgaacttgtttcaaatgcatgatcaaatgcaacctca caaccttg 3531 NM_002526 NT5E tgaattcattctactcatactacacacccagttatggaatgtccagagttctcgaagaaaata aatgact 3532 NM_002567 PBP gagctgggcaaagtgccgacgcccacccaggttaagaatagacccaccagcatttcgtg ggatggtcttg 3533 NM_002646 PIK3C2B gtatcaatgatgcaattactaggctcaacttgaaatcgacctatgatgtggagatgttgcgg gatgccac 3534 NM_002661 PLCG2 agcctgccatcaaggacatttcttaagacccaactggcatgagttggggtaatttcctattatt ttcatc 3535 NM_002692 POLE2 ccatcttaccaaggccaccacttgctgaaagcatcactaatgaattcagacaaagggtacc attttcagt 3536 NM_002738 PRKCB1 aggattcacggtgcacatgctggcattcaacatgtggaaagcttgtcttagagggcttttctt tgtatgt 3537 NM_002752 MAPK9 tgacaagcggatctctgtagacgaagctctgcgtcacccatacatcactgtttggtatgacc ccgccgaa 3538 NM_002832 PTPN7 aatgcttctgcttggccttatggaggagctgctccttccttacagccttggggatggacttgc ccacacc 3539 NM_002838 PTPRC ccgttatgttgacattcttccttatgattataaccgtgttgaactctctgagataaacggagatg caggg 3540 NM_002891 RASGRF1 gcgcaaggacggcacgcgcaaaggctacctgagcaagcggagttcggacaacacaaa atggcaaaccaag 3541 NM_002892 ARID4A gataagaccagcattgaggatgtagcagttgaaagctctgagtctaactctcttgtttctattc cacctg 3542 NM_002943 RORA ataaaaaccagttccataacaatactgaggcattgtttcccctttttactacggtgaccatttgt attaa 3543 NM_002966 S100A10 tccgccgccactcataccaactatcggcaagaacgcaccgtttccgcacttcatttttaccc cgcgcttc 3544 NM_002967 SAFB tgggctaaatgtgccgtgggttccacgccgtgtgcgcaagttccctgtgtgaaagcacgtc tgtcttcca 3545 NM_003037 SLAMF1 gcttttggggcaagctacggaacaggtgggcgcatgatgaactgcccaaagattctccgg cagttgggaa 3546 NM_003088 FSCN1 tgctactttgacatcgagtggcgtgaccggcgcatcacactgagggcgtccaatggcaag tttgtgacct 3547 NM_003177 SYK ggctgcaagaaatgtgttgctagttacccaacattacgccaagatcagtgatttcggactttc caaagca 3548 NM_003217 TEGT cttgagaacttactaaaggcacttccttcctgttaaacccctgttaactctccataaatttggtg attct 3549 NM_003243 TGFBR3 tgcgtttgcagcctttgtgatcggagcactcctgacgggggccttgtggtacatctattctca cacaggg 3550 NM_003254 TIMP1 cctaaggcttggaaccctttatacatcttggtcatcttgatctcataacgctggtataaggtgg tctggt 3551 NM_003290 TPM4 gccccctctccaattcatgtgttgaagccctcgtctccatgtgatggtaattggtgttggggc ctttgga 3552 NM_003299 TRA1 ttgggagagacttgttttggatgccccctaatccccttctcccctgcactgtaaaatgtggga ttatggg 3553 NM_003332 TYROBP ctacagcgacctcaacacacagaggccgtattacaaatgagcccgaatcatgacagtca gcaacatgata 3554 NM_003362 UNG ggttaagattgctgtgagctttatcagataagagaccgagagaagtaagctgggtcttgttat tccttgg 3555 NM_003451 ZNF177 agaaaggatactaaatgaaacaacaggggagatacaatattatctggttgcactaatcctgt gctgctta 3556 NM_003648 DGKD aaacgcctcttgtattgtcatgtacatagtccatacctgagtgctgtacataagttgttctgtgt ataaa 3557 NM_003656 CAMK1 aggttgggccactcacagctgcatgatgaggtagaggtggcccccactctcatagatgtc atccagggct 3558 NM_003810 TNFSF10 agggacaacatccttaagtcaaaagagagaagaggcaccactaaaagatcgcagtttgc ctggtgcagtg 3559 NM_003875 GMPS tgccagagatctgtggttattcgaacctttattactagtgacttcatgactggtatacctgcaa cacctg 3560 NM_003959 HIP1R tttaatattccgagctagagctcttcttcctacgtttgtagtcagcacactgggaaaccgggc cagcgtg 3561 NM_004049 BCL2A1 gatgtggatacctataaggagatttcatattttgttgcggagttcataatgaataacacagga gaatgga 3562 NM_004073 PLK3 tgtggttcagcgaatgggttggcttctccaataagttcggctttgggtatcaactgtccagcc gccgtgt 3563 NM_004091 E2F2 tggtcgtgtctttatgagcaccatgtaagcctccttgtattgagataattgggcattaaacatta aactg 3564 NM_004117 FKBP5 gggtgtgtgagtggttctgagcaaataactacagggtgcccattaccactcaagaagaca cttcacgtat 3565 NM_004126 GNG11 tgacctttccccggagactttcttaagcaccatatagatacggttatgtttttaaagcctatgtg cctac 3566 NM_004184 WARS gtttcttcctgtgagttccattatttctatctcttatgggcaaagcattgtgggtaattggtgctg gcta 3567 NM_004271 LY86 ccaaacataggaagcggcaatcagcccgcgcgtggaaccgagacaagtaaacaagac gccagatctctga 3568 NM_004289 NFE2L3 ctttccatcttggcagccatcctttttaagagtaagttggttacttcaaaaagagcaaacactg gggatc 3569 NM_004322 BAD agctggagacctagcacccagaagatgagaccgcaattcgagaatcaaagggccggga gcgatggtgagc 3570 NM_004354 CCNG2 tttgggggagggttgttaaacagtaatagataagtgagacagattgcttgttatttatggtcaa atggtg 3571 NM_004356 CD81 tgtcctttctaacacgtcgccttcaactgtaatcacaacatcctgactccgtcatttaataaag aaggaa 3572 NM_004358 CDC25B tgattggagattactctaaggccttcctcctacagacagtagacggaaagcaccaagacct caagtacat 3573 NM_004422 DVL2 ttcggagacctcagtggtggctgtgagagctacctagtcaacctgtctctcaatgacaacg atggctcca 3574 NM_004445 EPHB6 tccgagaacttgcccgggaagtcgatcctgcttatatcaagattgaggaggtcattgggac aggctcttt 3575 NM_004510 SP110 acattgctgctcccatctttagaagcaatctaccatagttcaccctctggccacagtagttca catcttt 3576 NM_004529 MLLT3 acaaaagtgtacctgtaaatgtcctgaatccagcattgttgagctgtcatcaacattcttgtgt ctgttt 3577 NM_004556 NFKBIE ggcaggtgctcttgttttacccatgttgggtcagcctgaaactgccaaccagtaggaagcat ggactctc 3578 NM_004577 PSPH atcgatgagctagccaaaatctgtggcgttgaggacgcggtgtcagaaatgacacggcg agccatgggcg 3579 NM_004619 TRAF5 tcctgaagctgagcaagactgtccttttaagcactatggctgtgctgtaacggataaacgga ggaacctg 3580 NM_004635 MAPKAPK3 ggctgggaaaccctagaccatgtcagataggacaacactgctgggttttacatccagatag taataaaca 3581 NM_004737 LARGE ttgtccccgcgttcgagacactgcgctaccggctgtccttccccaagtcaaaagcggagtt gctgtcaat 3582 NM_004844 SH3BP5 tgttggatggcacagatgtagcacatgtcatcgtcacagaagttccgtcagccagcactgg agagcactt 3583 NM_004951 EBI2 ttgtttcgttctgggtcataaaactttgttaaggaactcttttggaataaagagcaggatgctg caaagt 3584 NM_005013 NUCB2 atttagatatgctaatcaaagcggcaacaagtgatctggaacactatgacaagactcgtcat gaagaatt 3585 NM_005077 TLE1 ccaagcggacagaggggccatgggttgtaggattgaggaacggaatctgccgactcaca tgacagcccat 3586 NM_005127 CLECSF2 catagcacttagacaggactttcatgacccaatatggaacaatttgagtaccagaatagga gattatggc 3587 NM_005211 CSF1R actcccccaagctgactcatcctaactaacagtcacgccgtgggatgtctctgtccacatta aactaaca 3588 NM_005213 CSTA ttgggtacatgctgctaaaagcccgtcagctcgtcatccttgtttttgtcaacctggtatccag taagta 3589 NM_005214 CTLA4 cagaacactgtcttgaagacaatggcttactccaggagacccacaggtatgaccttctagg aagctccag 3590 NM_005271 GLUD1 tatttggccagggccttttgaacagtagtgtccccatgaagtgctagataatatatgtgtaag agtcagc 3591 NM_005292 GPR18 aaaacaatttcaggctcgagtcattagtgtcatgctataccgtaattaccttcgaagcatgcg cagaaaa 3592 NM_005347 HSPA5 ctcaaaggctctcactaccgtggaccacctagtctgtaactctttctgaggagctgttactga atattaa 3593 NM_005348 HSPCA acttttcattccctgtagttgacaattctgcatgtactagtcctctagaaataggttaaactgaa gcaac 3594 NM_005415 SLC20A1 gaatgtgaacttcgggcaagttaaatgggacagccttccatgttcatttgtctacctcttaact gaataa 3595 NM_005449 TOSO acgcctttgccctgatccaaatgttagcacttgctagtgaacgtctacttatctcaagttctatg ctaaa 3596 NM_005461 MAFB ttcagtcccagctgtaggcttgtaaatacccgccccgccaaaccgcatagagaacgtggc agcaagctga 3597 NM_005531 IFI16 tgctttgaattggcaccgaaaagtgggaataccggggagttgagatctgtaattcatagtca catcaagg 3598 NM_005582 LY64 agcctgacatgcgacagcattgattctcttagccatcttaagggaatctacctcaatctggct gccaaca 3599 NM_005601 NKG7 gcgatatattctcgtccactcccccgctatccaacgtcacatctaagcactatgacatgcac cgaccgaa 3600 NM_005606 LGMN ttccggacccactgcttcaactggcactcccccacgtacgagtatgcgttgagacatttgta cgtgctgg 3601 NM_005610 RBBP4 atgcacaaatcgtcaaatctgaaaccatcttaacctcttccttagagtagctttctaattattct ccatt 3602 NM_005623 CCL8 aataggaaaattcctatccagaggctggagagctacacaagaatcaccaacatccaatgt cccaaggaag 3603 NM_005638 SYBL1 cacacctgaataaaattgatgtgcatgttttagggatcaattacctaactgttccttggtctattt atgt 3604 NM_005652 TERF2 tctgctgggctatgtaggcaggttaatcctccacttctcatgtggttgaaccagtgtgttttttg gtaaa 3605 NM_005658 TRAF1 gtcctagcaataacctcttgatccctactcaccgagtgttgagcccaaggggggatttgtag aacaagcc 3606 NM_005856 RAMP3 acttggaggaccccccagacgaggttctcatcccgctgatcgttatacccgtcgttctgact gtcgccat 3607 NM_005935 MLLT2 catcacaagaaaggtgaccgaagagctgacggagaccactgtgcttcggtgacagattc ggctccagaga 3608 NM_005950 MT1G cattatcaactagatactacacataccagcaccactactcacactacagcccactcaaaaa catcatcca 3609 NM_006006 ZBTB16 cctggatagtttgcggctgagaatgcacttactggctcattcagcgggtgccaaagcctttg tctgtgat 3610 NM_006014 DXS9879E accccaacgattacaacacaacaccagcgcccaatatacgcgaatgaggcgccctatac ccgcctctcca 3611 NM_006115 PRAME ccaggatgtgcatgcatcttgaagcaacaaagcagccacagtttcagacaaatgttcagtg tgagtgagg 3612 NM_006162 NFATC1 gtacaattagttgcttattacgtatgattactcacagcgatctattgttccatataaccaaaaag catgg 3613 NM_006164 NFE2L2 tgctcagttaggtcagacctggggccagttgcccatttagcatctcaggcctcaggatcctc atttataa 3614 NM_006195 PBX3 ccaatagaatttcaacatgttctgtagcttagagtgctcacttactacctctgaacaatactca cgctgt 3615 NM_006218 PIK3CA ggggatgatttacggcaagatatgctaacacttcaaattattcgtattatggaaaatatctgg caaaatc 3616 NM_006254 PRKCD cttttcctctgccttcggagggaaattgtaaatcctgtgtttcattacttgaatgtagttatctatt gaa 3617 NM_006257 PRKCQ cggatctcactcagccgcagacaagtaatcactaacccgttttattctattcctatctgtggat gtgtaa 3618 NM_006317 BASP1 gcagtacatcgtttgtacctgaaactgccgccacatgcactcctccaccgctgagagttga atagctttt 3619 NM_006332 IFI30 gagcaaaacttgatagctttgcatagggaaagagggcattgatgctggggttttgaaaggt gagtaggag 3620 NM_006475 POSTN gattcattacaattcaaatcgaagagttgtgaactgttatcccattgaaaagaccgagccttg tatgtat 3621 NM_006498 LGALS2 taatgccaccgccacgagggaactggcttacgctgttggcacatttccttccagacggttct ccacagat 3622 NM_006558 KHDRBS3 actgtgggaaaactcgagagcgctcaggaattgtaggtagcaattactgtaaaggtggatt tatggatta 3623 NM_006620 HBS1L ctgtgctgttacactaccaaactgtcagtgaacccgccgttattaaacgattgattagtgtctt aaacaa 3624 NM_006644 HSPH1 gatgaataatgtcatgaatgctcaggctaaaaagagtcttgatcaggatccagttgtacgtg ctcaggaa 3625 NM_006734 HIVEP2 atatgcaaagtcgatgagaatatgacccaaaggacactggtcaccaacgcagccatgca agggataggat 3626 NM_006763 BTG2 tcttgtctgcaaacaggtccctgcctttttagaagcagcctcatggtctcatgcttaatcttgtc tctct 3627 NM_006841 SLC38A3 aaaccaggagttcagctggctgcggcatgtgcttattgccgttggcctgctcacttgtatca acctgctg 3628 NM_006889 CD86 ccttgattagactcctagcacctggctagtttctaacatgttttgtgcagcacagtttttaataa atgct 3629 NM_006892 DNMT3B aagaagtcgtttttagggagaacgggaattcagacaagctgcatttcagaaatgctgtcata atggtttt 3630 NM_006986 MAGED1 aaagtgctgagattcattgcagaggttcagaaaagagaccctcgtgactggactgcacag ttcatggagg 3631 NM_007311 BZRP cccacccaagtgtctagcgggctcctcacactcaacatgtcctaaatgctgggtatcgcat gaagcactg 3632 NM_007360 KLRK1 ctccacaggaccaaaccatagaacaatttcactgcaaacatgcatgattctccaagacaaa agaagagag 3633 NM_007361 NID2 taactgcagtctacccctactgcccaacaggaagaaagtaagtacagtaatgtaaaggaa gacttggagt 3634 NM_012203 GRHPR gtgattctgatatatgtacttgtcacattggtgttggacacatttgcgccaaaagtatggtaatt ctatt 3635 NM_012448 STAT5B tctgttccagcaaccctggttggggggtcagacttgatacactttcaggttgggagtggacc caccccag 3636 NM_012452 TNFRSF13B tcgattcacccatcagcccatctccagcgctgtcccaattacagccctagcaagtggagac aacaagaag 3637 NM_013230 CD24 ccccgaagtcttttgttcgcatggtcacacactgatgcttagatgttccagtaatctaatatgg ccacag 3638 NM_014246 CELSR1 cttctgtgactccagtgactcagacgttagacctcttgatgttttcccactggtccctgaggct ctgttc 3639 NM_014257 CD209L cccagcttccagcggtactggaacagtggagaacccaacaatagcgggaatgaagactg tgcggaattta 3640 NM_014338 PISD tacaatgacttcagcttcgtgacgcacaccaatagagagggcgtccccatgcgtaagggc gagcacctgg 3641 NM_014456 PDCD4 ttgtaagtgccatgtttattatctaatcattccaagttttgcattgatgtctgactgccactccttt ctt 3642 NM_014686 KIAA0355 tctccatgggctgtgagactgtgtgaagccgtttgtgtggtctccatgtaggtgctgtgttcc cggcacc 3643 NM_014762 DHCR24 attgtcttagacactgtggttgcaaaacccacggaaagcctcatttgtgtggaaagtcagag gaaaaatg 3644 NM_015187 KIAA0746 tacatgctgctaaggtagtgaataaatcagtaatgcaatattgtgggtccaaactactctttgc actact 3645 NM_015641 TES ataaaagccaagccacccatttgcttttaatccaaagaacatgtatagtttttgtacccagag actatga 3646 NM_015866 PRDM2 ttccttatcctaatgatgcgcttttgtcccgtaaatgttaacactcatgaagcataccccggcc tctcag 3647 NM_016076 PNAS-4 atgtaaagggttctagtagaaatagtgtcctaaggccaattacctaccatactaacaatcag cagataaa 3648 NM_016081 KIAA0992 cttcccataaggagaccaaattgggtgaacacgcctcgaggagacctcaggataacagg tcaacacctgt 3649 NM_016187 BIN2 aaaagtatctatagacacagacacttgcctatacagagacataaccacacacactcagag gatagtgaac 3650 NM_016336 UBE2J1 cagcatcctttcatcaacctacccaacctgtagctaagaatacctccatgagccctcgaca gcgccgggc 3651 NM_016628 WAC accgttaagctgggcaaaggaaatgacaaggggacggggtctgtgagagtcaattcagg ggaaagataca 3652 NM_017530 LOC55565 ttagctccccggggtcattgggtcgccacctcttaatccactcggaggaccagcgatctaa ctgtgctgt 3653 NM_017784 OSBPL10 gaagctgttaaagatttatgccagagccttgcaggatggagcacctctgggacaactaag agccaaggcc 3654 NM_017935 BANK1 tgctttcagggtgaagcaagcttgaatttggattgcctgctttctttaaagcgaattcatactat aacag 3655 NM_017955 CDCA4 cctgggtgaaaatcaggaaccgcacacagccacatcttcctagacctaagagtaaattatg gaggatttt 3656 NM_018442 IQWD1 ggatactttgaacattagaaggccgctagtaaaaatggtttataaaggccatcgcaactcca ggacaatg 3657 NM_018842 BAIAP2L1 cttaagcaaatcatgcttctctgtttcacgtagttgggttgacaagtttctgcctttaagataaat gagt 3658 NM_020151 STARD7 tgaactacactgttcagataaggtcacaatctgatgctgtcagtttgaccgagctggttttgct tatggt 3659 NM_020199 C5orf15 aaaggatcccaaacttgtaactaaattctgacatatctgttactgctgactcacattcattctcc gccat 3660 NM_020529 NFKBIA acttggccccatgaacggtccatgccgataagtaaacgtcgaacaattgcccttcaaccac tccctctaa 3661 NM_021813 BACH2 accaagaatgtctataatgcatcatcacacagtacctcaggttttgcaagcacattccggga agataact 3662 NM_021822 APOBEC3G catagctgcttgtaggtgccacctcttaaggccattaccatagcaattaatactgaacatgag ctttgga 3663 NM_021950 MS4A1 gtggcacattcttagagttaccacaccccatgagggaagctctaaatagccaacacccatc tgttttttg 3664 NM_021966 TCL1A cgcctggctgcccttaaccatcgagataaaggataggttacagttacgggtgctcttgcgtc gggaagac 3665 NM_022552 DNMT3A ggaaagggtatttggtttcccagtccactatactgacgtctccaacatgagccgcttggcga ggcagaga 3666 NM_023037 13CDNA73 cttaaacttaatgctgtcaagtgttagatgtgtgcatgtgaacttgttgcactgcagaaacata ttcaga 3667 NM_024708 ASB7 tcagtgataaaggtaccacaccgcttcagctcgccattatccgagagaggtcaagctgtgt gaaaatcct 3668 NM_025113 C13orf18 ctgtgccggctgtggaactccagtagagcctagtaagtacggataatggatcgcctgctta tgatgtgat 3669 NM_025216 WNT10A aggccacagatgtgagtaagcgagacacaacacttgtcctcttggaggttacattcttgctg gggggagg 3670 NM_030666 SERPINB1 aaactggaagagagttacactctcaactccgacctcgcccgcctaggtgtgcaggatctct ttaacagta 3671 NM_030764 SPAP1 cagacactgtgcaaataaattatttctgctaccttctcttaagcaatcagtgtgtaaagatttga gggaa 3672 NM_030775 WNT5B tcatccacgtgcacttgtgcggcatctgcagtttacaggaacggctccttccctaaaatgag aagtccaa 3673 NM_031305 ARHGAP24 taactctcccttcatatcttttcacctatttccagtccttatcatagttgataaaaacctcagact catc 3674 NM_031942 CDCA7 ccattcaatgtttgatgcataattggaccttgaatcgataagtgtaaatacagcttttgatctgt aatgc 3675 NM_032991 CASP3 gtatgacatttcacgggagatttcttgttgctcaaaaaatgagctcgcatttgtcaatgacagt ttcttt 3676 NM_033208 TIGD7 ctcctctcttcatattgtccgttttccggtattgagttagggaaagtatgcaggtattcctgtcat tcct 3677 NM_033274 ADAM19 ttccaaagtcagtaattgtgttaaccacgtgtataacagctctgctggacacccaagaaagc catgggaa 3678 NM_057735 CCNE2 cctaactggggctttcttgacatgtaggttgcttggtaataacctttttgtatatcacaatttggg tgaa 3679 NM_078467 CDKN1A cccctggaggcactgaagtgcttagtgtacttggagtattggggtctgaccccaaacacctt ccagctcc 3680 NM_079421 CDKN2D cagacgagacccaagggcagagcatttaagagtgaagtcatgacctccagggagccta gaagctggtggc 3681 NM_080593 HIST1H2BK acctcaaagctctcccgtggggcgattctcttgttgttccgatagtgtctcgcgggcgaaac caccagca 3682 NM_138340 ABHD3 ggataccaaacaattgatgattattatactgatgccagtccgagtcctagactgaagtcagt aggaattc 3683 NM_138379 TIMD4 tcataacccagcccccccggcaagttgatacttgatcatgaagtcccccaaaaataccaaa tacttttat 3684 NM_139207 NAP1L1 tgagtatgtcacttacccgtgcttctgtttactgtgtaattaaaatgggtagtactgtttacctaa ctac 3685 NM_139276 STAT3 gtaatttatataatccctgaaacgggcttcaggtcaaacccttaagacatctgaagctgcaa cctggcct 3686 NM_144646 IGJ ttaaccccagatgcctgctatcctgactaatttaagtcattgctgactgcatagctctttttcttg agag 3687 NM_145804 ABTB2 ctcctctgccctagagctgtttgttcaatcactgatgggcaaaggggagatgtagctaactg gtggccct 3688 NM_152785 GCET2 tactcttcagcagagttccctgatggccttgtacagagaacccgatgattgatgagggtata gcacagct 3689 NM_172373 ELF1 tgagccttgggctaatctggctgagtagtcagttataaaagcataattgctttatattttggatc atttt 3690 NM_175870 LOC90925 aggttgttcatggtgtatattacatggttaacatcaaaaggctgctaataggcacctcttcaat attaat 3691 NM_177968 PPM1B aatgcaggaggcagcgtgatgatacaacgtgttaatggttcattagcagtatctcgtgctct gggggact 3692 NM_181443 BTBD3 ctttatcccaccattagagagagaaatgcgatgatgttcaataatgatttgatggcagatgta cattttg 3693 NM_181838 UBE2D2 tttattgaacaagttagaggcataagcttaagagcatttccatgaaacaacacatgcagcatt ccaggaa 3694 NM_182746 MCM4 ctgaagcagtctgcaactgatccccggactggcatcgtggacatatctattcttactacggg gatgagtg 3695 NM_182776 MCM7 gagctcaatgtctggcaggtcaatgcttcccggacacggatcacttttgtctgattccagcct gcttgca 3696 NM_198833 SERPINB8 catacatggaaccatacatcatctatgctttgtagtatgactcctgtcactcagtacaattatttt gaga 3697 NM_201593 CACNB2 accgctgacatctcgcttgccaaacgctcggtattaaacaatcccagtaagcacgcaataa tagaaagat 3698 R99527 MGC39372 tgtggataaagaccccagataaagatgcctgtgttgctcaactcttgtaaatactcttgagac attttga 3699 T66903 LOC54103 atacagtggcataaacgatgctcttcctagtagcttaataggccacaagctagtttctgttgc actctga 3700 U37028 ITGAD tggacccaggtcgtctgacttctcgtgccattttcaatgaaaccaagaaccccactttgactc gaagaaa 3701 W56129 SFRS9 gtctttgtgggttgctctactatggagatcaacagttactgtgactgagtcggcccattctgttt agaaa 3702 X58529 IGHM cacccatagcatgttaaccctgccgcgtggaatccccccgggaatcgaaattccgaaccc aatgcagtcc 3703 AA188785 LOC286025 gtaacatactcatcaactatgatagacttaacacttgttacctaatgaacaaggaggatgtgc atttcgg 3704 AA601122 SECTM1 aaaatctgaaagaaacgtctttagtggctttaagccccaaaacgtccctaaggcgtcctcg agatgaaga 3705 AA642467 SLC2A14 agtgaaacctgaggattcctcgttgaagcaggtattcatccatggggttcttccgcggtgaa gccagctt 3706 AA682722 LARP gcttcacacaacacgtctaccataagtatcgtaggcgctgccttaatgagcggaaacgctt gggcattgg 3707 AA757235 LOC399933 ctaactgtttattgttggtatgtagaaatatatctgatttgcatactggtcctttatccagcaacc ttct 3708 AA765313 FZD3 tttgcatgactgatagctgtaactcacagttaacatgctttcagtcaagtacagattgtgtcca ctggaa 3709 AB002310 HUWE1 gcagagactcaccgcactgtgttaaaccagatcctacggcagtccacgacccaccttgct gatgggcctt 3710 AB002333 ZNF518 catttcagaatagccatatcaggaaaataatgtcgagatatgtacttcttgcctttaagttttaa cagcc 3711 AB024402 ING1 caggaaattactgcccacttgtcaagttcagcccaccatctgtttgaagattatatgaagttta aattct 3712 AB028952 SYNPO ttggctggtagagccttctagaggttcagaatattagcttcaggatcagctgggggtatgga attggctg 3713 AB032991 NDFIP2 tcatcctgtgtataattgtagactgtaccaagaagcaactaccttagctccactgccctttga gggatgg 3714 AF008915 EVI5 aggtatagtggatgctatttatgatccaagtttttacatcacatccattgatctgcctatcccttc tttt 3715 AF108138 C15orf20 gaacataagctgcaaaatgtgcacccatattttaagctgctttttcaggggataaatagtgttt ggggac 3716 AF116668 LMO2 agggtggggtaagggatttcttaggggatggtagacctttattgggtatcaagacatagcat ccaagtgg 3717 AF143327 FLJ32810 gtggatctattcaaagcttaacttctgtaggttccaaggagacacccaaagcttcaccaaac ccagacct 3718 AF200348 D2S448 ggatcccaccctaccacgactacagggtctactgcaatctatcggcggcacacacgttcg aggacctgaa 3719 AF245480 MONDOA tctttgtattggagatatttctgtaactcattctcttggtgctcacgattgccatggccataggg ccaca 3720 AI075159 SPTA1 gcacaactgattgatgagcggacaaagcttggagactatgccaacctaaaacaattctacc gagaccttg 3721 BU948323 TCF4 ttcatcttttgcatccaacaggcagaatatgatctgtgtccaaaagtgaacttgagtcaggaa tgaatca 3722 AI675029 C7 acagatacaaactatttctatcctgagtagtaatctcacacttcatcctatagagtcaaccacc acagat 3723 AI694012 PSMA5 ggggaaagtgagtcaatacctgttagtgttaggctattaacaatagttaggtgaaaggtaat gagggcat 3724 AI732248 COL4A1 gacctgcaattactacgcaaacgcttacagcttttggctcgccaccatagagaggagcga gatgttcaag 3725 AJ007509 HNRPUL1 tgaacttgaaaccttttattccgggcgtcttggtagtttctggtgggattcagtgggtgagag ggaagaa 3726 AK022224 ACTN1 gctgtattcatttctccaatctcatgtccattttggtgtgggagtcggggtagggggtactctt gtcaaa 3727 AK023928 PSCD1 agacagagaggcacctgggtcagtattagtctatttatcagaggtgtaaataatctatgtata gtttttc 3728 AK024580 NRP1 tacagaaaacggtgccatccctgaacacggctggccactgggtatactgctgacaaccgc aacaacaaaa 3729 AK025005 MARCH1 ttataaaccagagaaaggcagcaaatatgtctatctttttaaatattcatgataatggaccag gcacggt 3730 AK091853 COL3A1 atggagcaaaacagtctttgaatatcgaacacgcaaggctgtgagactacctattgtagata ttgcaccc 3731 AK126650 CAPZB acatagggacctacacacagaggagtgaacttagggttctagggactatggccgggtca ccggtggccag 3732 AK127124 ARHGEF4 aaagatgccggaagccccaaaaagcccaccctagtgagtctgcctctaggacccgaagt tctctccccag 3733 AK127132 DRG1 gaagcctttactagcagcttcaacccagtcctccttaccttgcacctattaacgttggttcaac atgaag 3734 AK129940 GNAI1 ctttagttttcgacattatttttaggttttaagagtggcaacttaggattttagggtgatggctttg gaa 3735 AL049313 CLIC5 ttggactggtggcatcatgtaactgctaaccttacagtaaaaacccaagaatgggtcaaaa atgtcttcc 3736 AL049327 CBLB cagagtcagcatgctaattcactctagttcaaatccacattctagttgaatccctgcaatgtaa cttgac 3737 AL049449 GAB1 gatcaggtttagacaatgagctttggttgtgttcttgttagtcctaatattggttttcagtttggaa tta 3738 AL050391 CASP4 caagaagaatcatgatgagggatgggatgaaggcagcaaggggtaaccatcttgacctt ctgttttttct 3739 AL137527 LRCH3 ccctgcggtattgttttccctctgttgtatgtatagatatatgctacttgtcaattttccaattttga aa 3740 AL353942 SEPT11 gacctgtagtggcatgagagtgtataacatttcctaagatgacaggcaaagtagaactaac cctggcact 3741 AL833915 TDRD9 ccagagagagttgcgcagcttcaagacattgcccgtcagaagcttttaggtttgttctgtca gtcaaaac 3742 AL834278 USP30 atgtgaccttaaagtgtactgcaaagctgtaactttaagtaattgctgttctgccactgcttact ctgaa 3743 AU252485 MAP7 gcggtcagtttccaccatgaatctttcgaaatatgttgatcccgtcattagcaagcggctctc ctcttca 3744 AV650179 PRG1 acagctcgtccttgggagagaaaaagctcccacagtatgtggcgtctgaggggtaacag cattatatttc 3745 AV686223 KIAA1407 tcccacctgcaactgctgaataatacactcagtttgtcttctagtactcagctcagtttgatcta gatat 3746 AW014009 MAP2K3 gagcaccttgcagacgtgatcttgcttcgtcctgcagcactgtgcggggcaggaaaatcc aagaggaaga 3747 AW190768 SLC13A3 tcattactctccacccccttactctgctataatttctccttaataggacactgtataacttattttct ta 3748 AW292143 GFAP ggttgtgggtgaccagttgcacttggcctctggattgtgggaattaaggaagtgattcatcct cttgaag 3749 AW439398 CCND1 tggctgaagtcacctcttggttacagtagcgtagcgtggccgtgtgcatgtcctttgcgcct gtgaccac 3750 AW452039 HRMT1L3 cattttcttagacgtttgctccaccagatttaaccaaatgtaactcccacattgagtttatctata ttga 3751 AW615076 LOC492304 gtccattggacctaaactacacgcagactgagcatagacagagcgcagacaatcacaaa gcagaaaagca 3752 AW664012 ALOX5 caagtgcaaagttcacacctgatttttaagacttagaataaggaggtggggaatgtgaaata tctcattt 3753 AW967479 CD38 aaggaaaaacaaataagcgagaaccgcgacgagcaccacataagccgtaggaccgca tgaaagaagagac 3754 AW970654 PHTF2 ttcaaagagaattgtggcagatgttgtgtgtgaactgttgtttctttgccacatgtgttgtatttg aaag 3755 BC028066 NALP1 accaggaaccaccttggcaagatatttacccaccggccatctctgtttactcatgaatgttaa atgttaa 3756 BC034289 LOC87769 gggagagctcacttactcttcaacttaatggcagactgtgatcgctaactgcatctggcaca aaaacatg 3757 BC042366 PCDH9 tcatcatcaccgcaactctgacgtttcctacaagaagttagagacttaagcagtattggcatc ggatgga 3758 BC045532 LSM8 gaattttacaagctggttaattgatgtcttgttagtagcttgaaattggctgtggtgggagtgtt tgcac 3759 BC050383 TMPO gacacagtatcatgaaagtcctatttcagtaagacccatttacatacagtagatttttagcag agatctt 3760 BC050602 HIST1H2AC gctggaatggtggtaagtgaactgaaaattccagtcactcttgggctagactcaacgttctt aaaaacta 3761 BC058855 VEGF gggaaaagatattaacatcacgtctttgtctctagtgcagtttttcgagatattccgtagtacat attta 3762 BE147267 ECE1 tctgggaacaccaagcaccctgaatcgagactgcaggagccctgcggggtgagactgtg tcagagataca 3763 BE549606 BZW1 tattcaaggcttaactgaaaccggtactgatttggaagcagtagctaagtttcttgatgcttct ggagca 3764 BE798965 LAMC1 gtggcatcctacttacgtacgtggcataacacatcgtgtgagcccatgtatgctggggtag agcaagtag 3765 BE927772 SFRS3 caaaattacactatccacctggtacctaagtcttgtcatggacttacaggtttgcatgggttcc aaatac 3766 BF055235 RIPK1 gggcctgggtgagttctgtttgctccttgtaccaccatccaaatggtgttatcaaatctcttag attcca 3767 BF513638 WNT3 ggggctttctttttagttctctagggtctgataggaacagacctgaggcttatctttgcacatgt taaag 3768 BG682263 HDAC3 tgtggagatttaagagtggcttgggatgctgtgtcccaaggaatttcttttcacctcttggaag ggctgg 3769 BG683220 PMS2 tacatctcaggtttcatttcacaatgcacgcatggagttggaaggagttcaacagacagaca gtttttct 3770 BI493513 PHF8 gggaggggttgggagtgttagtaatcaaggtttagaacaccatgagatagttacccctgat ctccagtcc 3771 BI559738 GPR56 actggaaccgacatgctgggagattacatcttctctatggcaagcgtgacttcttgctgagt gacaaagc 3772 BM709325 BCL7A ttccacaaagtgctggcacttacacccacaacccggaaggctgtggaccgattcctctag ggtggtgacc 3773 BM711190 MED28 caggactttgatctcttctgttgccctcgctaggttctccctggtgggttagtgctttgtatctgt ctct 3774 BM727177 GOLT1B aagcattattagacttgaaagggtttgataatctcccagtccttagtaaagattgagagaggc tggagca 3775 BQ009245 GPM6B caactatctaaaacctaattgcaaattgaccacagacctctaacctcctacttttatagacttg aatact 3776 BQ021469 AGPS aaggatttgacccaaatcagctaagtgtagccacattactgtttgagggggatcgtgagaa ggttcttca 3777 BQ215285 LEF1 gcttcttgtcacctaacaaaggcgtaggagtaacctcgcactttgctagctaacctgactcc gggtgagg 3778 BQ898221 ITGA6 agactgtagctcagtattcgggagtaccttggtggatcatcctagtggctattctcgctggga tcttgat 3779 BU929213 SESN3 tgactggactaatgtaaggcagatgacgtgatctttaagactgctatatatatcagtctcttac tctata 3780 BU954396 RPL11 cagatgtgaattctcaaaagttagccattgctgcaatctctgctgttgcctcctgttctgaaaa aattaa 3781 BX095432 CNTN5 gatgtaagccttaagccttcgcagtttccacgtggcattgagcgttcgagtgcacagaacta gaagtcaa 3782 BX640908 EVI1 cccctttccgaatttcaaggaccaaggtgacccgacctgtgtatgagagtgccaaatggtg tttggcttt 3783 BX648339 USP53 caaggaaaaggatcatataaacatgaccgagttgtacctcagagtcgagcttctgcacaaa taataagtt 3784 BX648365 SEPT7 tggcactgctaaaatagaatatagcatctttcatatggtaggaaccaacaaggaaactttcct ttaactc 3785 BX649193 TKT tcaccatcaagcccctggacagaaaactcattctcgacagcgctcgtgccaccaagggc aggatcctcac 3786 C05886 ETV6 gtacctgcctaatccacccggcgtgactcatttcaacactaagtactaggggtgttgtcagg agacaaat 3787 D31762 TRAM2 cacttacatcatagataaattttagcttcccagtaactgagggatttgtttcctaacgccattgg aggcc 3788 D86967 EDEM1 gtgctggtgaaaaggtagggctgagtgattaccttagccacagggtggctgagcaggaa ctttagaagaa 3789 H41942 NPEPPS ggaatggttaaacacaaaaggctgatagctggtatcacatagttggagtcagtgcataattc caagtggc 3790 M60028 HLA-DQB1 aagaaggctttgcggatccccggagaccttcgggtagcaactgtcaccttgatgctggcg atgctgagct 3791 M77810 GATA2 gggaggtagctaattctcctctgtagctcttgcaatcccgttgattctaacatcaggcttctga gagttc 3792 N26272 MSI2 tcctcgttttgaatataagattcccaaacagaggagcataacacattcctagtacctaagttc caggtgg 3793 N28431 COL6A1 atgccatggactttatcaacgacgccaccgacgtcaacgatgccctgggctatgtgaccc gcttctaccg 3794 N41620 WWP1 gggaagtcatctgtaactaaaggtggtccacaaattgcttatgaacgcggctttaggtgga agcttgctc 3795 N53163 COL27A1 gtcgagtttgccatcagccgggtccagatgaatttcctgcacctgctaagctccgaggtga cccagcaca 3796 N54946 EWSR1 atagacgtgtcatgtagtggggtgtaatcggtatatgaacggtagggtagatggtattagatt ctaattt 3797 N70000 UBE3B cttttgtaactggtgttcactgacaccttgatggctcttgatggctctaaaaagttgtaggatttt ttgt 3798 NM_000016 ACADM caaaatctatcagatttatgaaggtacttcacaaattcaaagacttattgtagcccgtgaaca cattgac 3799 NM_000024 ADRB2 cctacacccttggacttgaggattttgagtatctcggacctttcagctgtgaacatggactctt ccccca 3800 NM_000033 ABCD1 agcctaatttattggattccctattcgtagccatctccgtggccaatgtgactaccgtgccag cagcggg 3801 NM_000062 SERPING1 atgctctcaatcatggagaaattggaattcttcgatttttcttatgaccttaacctgtgtgggct gacag 3802 NM_000089 COL1A2 tccttgatattgcacctttggacatcggtggtgctgaccatgaattctttgtggacattggccc agtctg 3803 NM_000099 CST3 aaacacacctctgaggccagcggccagcgtctgactcacaagccatgactgccccacct tcttacaacaa 3804 NM_000110 DPYD tattgtcgactgcatcaaaatggtttccaggacaacaccttatgaaccaaagagaggcgta cccttatct 3805 NM_000118 ENG agtagccaagctgcttgtcctgggcctgcccctgtgtattcaccaccaataaatcagaccat gaaacctg 3806 NM_000120 EPHX1 ctccaggcttttcttggggaagataccccttttctgaggaatgagtttgcctccgtcccctgc ccatgct 3807 NM_000147 FUCA1 attaaaggaactgagtacattaccctgatgtctaaatggaccaaagatctgagatccattgt gattatat 3808 NM_000169 GLA tgggctgtagctatgataaaccggcaggagattggtggacctcgctcttataccatcgcag ttgcttccc 3809 NM_000182 HADHA ctgtctgtgcagatgctttgcccaggcttctcaccacggtgtaccgggatattaaacctcttt ccccagc 3810 NM_000194 HPRT1 gaaaagtaagaagcagtcaattttcacatcaaagacagcatctaagaagttttgttctgtcct ggaatta 3811 NM_000214 JAG1 gtgtcggtcttccagtctccagccggtgaagacaaagtgcacctctgactcctattaccag gataactgt 3812 NM_000234 LIG1 agtgacaagggcatctcccttcgcttccctcggtttattcgagtccgtgaagacaagcagc cggagcagg 3813 NM_000246 MHC2TA tcaattctcatttgtcacacactttggctattagagatcaaccccttcgctcctgtgtcttgcaa tggca 3814 NM_000249 MLH1 gtgccccctttggagggactgcctatcttcattcttcgactagccactgaggtgaattggga cgaagaaa 3815 NM_000251 MSH2 ttgggattcatgttgcagagcttgctaatttccctaagcatgtaatagagtgtgctaaacaga aagccct 3816 NM_000277 PAH actttgctgccacaatacctcggcccttctcagttcgctacgacccatacacccaaaggatt gaggtctt 3817 NM_000305 PON2 ctcagtgtatgatgggaagctgctcataggcactttataccacagagccttgtattgtgaact ctaaatt 3818 NM_000341 SLC3A1 ataatatgatttcgggccttcccgctaaaataagaataaggttaagtaccaattctgccgaca aaggcag 3819 NM_000361 THBD caaagctttttccagaggctattattttcactgtagaatgatttcatgctatctctgtgtgcacaa atat 3820 NM_000382 ALDH3A2 tggtctggacaagaagcgagtaagccactgcggttggtcatactgaagggaattgatggc aagaggatcc 3821 NM_000395 CSF2RB ggagtccagagcccacgtctactgcggaaaagtcaggggaaactgccaaacaaaggaa aatgccccaaag 3822 NM_000417 IL2RA caaatcaatgcgtacgtttcctgagaagtgtctaaaaacaccaaaaagggatccgtacatt caatgttta 3823 NM_000418 IL4R ctcaggtgctagggaaggcgggaaccttgggttgagtaatgctcgtctgtgtgttttagtttc atcacct 3824 NM_000435 NOTCH3 acacaggcatgactgggatcccgtgtaccgagtacacgacccaggtatgtaccaagtag gcacccttggg 3825 NM_000448 RAG1 gaggcaggatatataagcgccagtggtagttgggaggaataaaccattatttggatgcag gtggtttttg 3826 NM_000484 APP caagaagagtagaagacagagccttactttataatcagaattatgaaaagaggagccaat gagagggaaa 3827 NM_000485 APRT ggaagcagctccgggtaggtgatgggtaacattccttaaatggtgcatgtcactggcctttc agctggga 3828 NM_000536 RAG2 ttatataccttcaagcaaccctttggattatgcccatgaacaagttagtttctcatagctttaca gatgt 3829 NM_000546 TP53 ttggtagtttctacagttgggcagctggttaggtagagggagttgtcaagtcttgctggccca gccaaac 3830 NM_000561 GSTM1 tctgcccatataagaagaactgtgcggcacagcgcccgctactacagctcgtcacacggt gttgtccgac 3831 NM_000574 DAF gtcttctatctgggcacacgtgtttcacgttgacaggtttgcttgggacgctagtaaccatgg gcttgct 3832 NM_000578 SLC11A1 atcgagctagccattgtgggctccgacatgcaggaagtcatcggcacggccattgcattc aatctgctct 3833 NM_000594 TNF atatttatctgattaagttgtctaaacaatgctgatttggtgaccaactgtcactcattgctgag cctct 3834 NM_000598 IGFBP3 taggctttgtgttatgtgatggcactatttcaattggctttctaattggacaattgatactatgct atct 3835 NM_000601 HGF tatcttgtgccaaaacgaaacaattgcgagttgtaaatgggattccaacacgaacaaacat aggatggat 3836 NM_000604 FGFR1 acctctgccccagataggtggtgccagtggcttattaattccgatactagtttgctttgctgac caaatg 3837 NM_000610 CD44 accaagaattgattttgtagccaacattcattcaatactgttatatcagaggagtaggagaga ggaaaca 3838 NM_000628 IL10RB gtaattttcagccttttatatcactaaaataagatcatgttttaattgtgagaaacagggccga gcacag 3839 NM_000629 IFNAR1 aatgaagtttgctgtggtattgcatagccttgctttcttgaactaaactgtttgcccttcacaag tagtt 3840 NM_000640 IL13RA2 tgatacatgaagactttccatatcaagagacatggtattgactcaacagtttccagtcatggc caaatgt 3841 NM_000660 TGFB1 tgctggcacccagcgactcgccagagtggttatcttttgatgtcaccggagttgtgcggca gtggttgag 3842 NM_000700 ANXA1 tcagaagatgtatggtatctccctttgccaagccatcctggatgaaaccaaaggagattatg agaaaatc 3843 NM_000701 ATP1A1 gagtttggaactctaccctggtaggaaagcaccgcagcatgtggggaagcaagacgtcc tggaatgaagc 3844 NM_000717 CA4 caccacaccgacctgcgatgagaaggtcgtctggactgtgttccgggagcccattcagct tcacagagaa 3845 NM_000732 CD3D agtttcagatcctcgtaggccacaggggaaaaaggtccatttgtctcaccgggaggctca atattgcctg 3846 NM_000773 CYP2E1 agtgcagagcgcttgtacacaatggacggtatcaccgtgactgtggccgacctgttctttg cggggacag 3847 NM_000801 FKBP1A ggcgggggcaccatattgcgcacaaacacccctatcacgaaaattacaccccccaacgg caacttttaca 3848 NM_000852 GSTP1 ttgggtcggccagttcagcggatgctatggtgccggggcgacaaggtcgcaactataatc taaccgcctt 3849 NM_000856 GUCY1A3 tgactttgactcaataaaccactcaccctattattggaaagtgccataggccttgagaaagta tagttac 3850 NM_000867 HTR2B actgaagagcgagttagttatgtatagcagaactggcagttgtcatcaaacataatgatgag taagatga 3851 NM_000878 IL2RB cccctaccccgacccctccacgtatctttcctaggcagatcacgttgcaatggctcaaaca acattccac 3852 NM_000885 ITGA4 cactggcaatagtatggctcccaatgttagtgtggaaataatggtaccaaattcttttagccc ccaaact 3853 NM_000887 ITGAX cagcatcagctcagggcttcatcgtggggctctcagttccgatttcccaggctgaattggg agtgagatg 3854 NM_000905 NPY tgtgctgcactcctgcaatgttaaccttggtcagcactcggcacacccctgcgcggtgcac ataacagca 3855 NM_000906 NPR1 cttactgggaggagaaagagtcacctgaaggggaacatgaaaagagactaggtgaaga gagggcagggga 3856 NM_000953 PTGDR aaacgcagctgcaactgaagcggagactctaaacccagcttgcaggtaagagctttcacc tttggtaaaa 3857 NM_000960 PTGIR gaaggggaggctgctgcattgtgggtgatgacgtaggacatgtgcttggtacaaaaaggg cctgagacat 3858 NM_000964 RARA ggcaaatacactacgaacaacagctcagaacaacgtgtctctctggacattgacctctggg acaagttca 3859 NM_000967 RPL3 ggctcagagtgagcgctgggtacagcgcccgaatcggacagtgtagaaccattctctact gccttccttc 3860 NM_000968 RPL4 gaagggctctttggatctctgggcttttcaagattctgctaagatctgtattaatcatcttgtgc atggg 3861 NM_000970 RPL6 gggcacgaggggacatatctgtgaaccctccacggtggaaaaaatgccgcccttagtcg ggtggggaaaa 3862 NM_000972 RPL7A aaccttgaaaatctcagaaaacagtaagccaagctaactgcctctttttgtcttttcagatccg ccgtca 3863 NM_001001547 CD36 tttgatagttctgaagagcaaatgaatcctagtacattgaagagtaccgtactctatctggca cttaatt 3864 NM_001005 RPS3 atggaagagggtgtagtaatgcgtatcagaggtagcggagaatgaagagcgacaagtgg gacgagctgta 3865 NM_001009 RPS5 gaagagcgaggagcgaagaaggaagacgagacgactagaagcacacaataagacga caaccagacacaaa 3866 NM_001015 RPS11 acaatgccgggggccctcagcttggtgttggagaaaggcccatagtgtcatgttacagcat cctgtgggg 3867 NM_001019 RPS15A tgagtgttgatgtttttctgcactagaaggcactatgttgaactattaaacttaccagcactttct tttt 3868 NM_001069 TUBB2 gtgcggaggaagtaattaggttgggcgagtcggtatcggttgtgatgttggcgtatcgtatg tctggagg 3869 NM_001079 ZAP70 tcctgaagcgcgataacctcctcatagctgacattgaacttggctgcggcaactttggctca gtgcgcca 3870 NM_001092 ABR atacagccttttgggtaaacactgggaactccagaagttgtggggagagtggggaatcag acagccgcct 3871 NM_001130 AES ccacacctgtgtctgtatatagtcagcttatctcgtgttcaatcgtctgatctctacagagaga agtgga 3872 NM_001150 ANPEP gtacctgagctacaccctgaacccggacttaatccggaagcaggacgccacctctaccat catcagcatt 3873 NM_001165 BIRC3 tctagtagtatgcaaagattgtgctccttctttaagaaagtgtcctatttgtaggagtacaatca agggt 3874 NM_001175 ARHGDIB attagcaacacttagccaactatatgccacctatctgcctatgtatacttttcaatgcccaact attctt 3875 NM_001178 ARNTL ctggaagctgtaggctaatgggactggcccacagctttcctactctacttcattaccacact gggtttca 3876 NM_001207 BTF3 attgtgtgtcattgtattctttggttctgctcccccactattgaccaatgtatgagatgggaaga ggggg 3877 NM_001211 BUB1B tctggaaacttagccaaaatatttctgagctaaaagatggtgaattgtggaataaattctttgt gcggat 3878 NM_001219 CALU agggaagccgtgcttctgaggaacaactctaattagtacacttgtgtttgtagatttacacttt gtatta 3879 NM_001226 CASP6 ttcctttggatgtagtagataatcagacagagaagttggacaccaacataactgaggtggat gcagcctc 3880 NM_001228 CASP8 gcaataaataccagacacgtacaaaatccagctatgaatatagagggcttatgattcagatt gttatcta 3881 NM_001229 CASP9 ggatttttggctacacacaaaccagtatcgctcatagatcagcaaaccggggcctactaga gtctgaaca 3882 NM_001237 CCNA2 ataccctggaaagtcttaagccttgtctcatggaccttcaccagacctacctcaaagcacca cagcatgc 3883 NM_001239 CCNH accaatgtcattctgccacgtatgttccatatgtcctatctatctgccctgcacaattatgaga gggaag 3884 NM_001255 CDC20 gcaaagaggcaagcgcaagacgacaggaaacgaagcgagagacgagaagccggtg acgagcaggagaaag 3885 NM_001256 CDC27 gagccccactattacatctcccccaaacgcactgcctcgaagaagttcacgactctttacta gtgacagc 3886 NM_001265 CDX2 taacatccaagccagagtttttaaagccttctggatccatggggggagaagtgatatggtg aagggaagt 3887 NM_001273 CHD4 tgaggttacagatgtcagagcgtaacattctcagccgcctggcaaaccgggcacccgaa cctaccccaca 3888 NM_001274 CHEK1 tttcaaccttcggtgtgcttgggagtggcgattgtgatttacacgacaaaatgccgaggtgct cggtgga 3889 NM_001280 CIRBP agtccttgcccacaacgatgtggagccctgtgaaagtcggattcgaataaagggccacgt gtgcacccag 3890 NM_001295 CCR1 cattacctacacttccactacccaaagacaaaatgtgcccactgtgtgcttttgagtgtatttt ctttta 3891 NM_001313 CRMP1 gaaacctccaccagtccaacttcagcttatcaggtgcccagatagatgacaacaatccca ggcgcaccgg 3892 NM_001337 CX3CR1 gagagaataagtcatgttccttcaagatcatgtaccccaatttacttgccattactcaattgat aaacat 3893 NM_001344 DAD1 gatgaagagtggcggcagacagagcgcaggagagcgaacagaacgaccaagaagag ccagacgaagagca 3894 NM_001345 DGKA tgagcaacctgtccctagaaggcatcgcagtgctaaacatccctagcatgcatggtggctc caacctctg 3895 NM_001398 ECH1 aaggagatgatgtggcccggatcagctggtacctccgtgacatcatcactcgataccagg agaccttcaa 3896 NM_001404 EEF1G cccctaatcactgtcgcctgtaattctccaaaacccttccaccaattcatgcgctatcaaatgt attatt 3897 NM_001428 ENO1 ttctcgcctcactttccaccaagtgtctagagtcatgtgagcctcgtgtcatctccggggtgg ccacagg 3898 NM_001436 FBL gagcaagcacataaacgagggaacacatcatacaccagtccgcgaagcgctaggacca tacgagacagac 3899 NM_001441 FAAH gtagtggtgcatgtgctgaagctgcagggtgccgtgcccttcgtgcacaccaatgttccac agtccatgt 3900 NM_001456 FLNA aagaaccgcaccttctccgtctggtacgtccccgaggtgacggggactcataaggttact gtgctctttg 3901 NM_001459 FLT3LG agactgtcgctgggtccaagatgcaaggcttgctggagcgcgtgaacacggagatacac tttgtcaccaa 3902 NM_001462 FPRL1 agagtcaaatttagagcagaaaatactagcaaaggggactgaaaagcggtggccaattg agcttcaaatg 3903 NM_001489 NR6A1 tgatgattttggcccttgatggatctaaaactcggaacattactcctcaatgccgtttccccag ttgctc 3904 NM_001513 GSTZ1 ctggccttgaaaggcatcgactacgagacggtgcccatcaatctcataaaggatgggggc caacagtttt 3905 NM_001515 GTF2H2 tgaatgtaaaatctgtggtcttactttggtgtctgctccccacttggcacggtcttaccatcatt tgttt 3906 NM_001540 HSPB1 ttgtcggtcaggcgcgacaccacgctcgcaatgataccacacatcactacaactccgccc gacgacaaac 3907 NM_001560 IL13RA1 catcccctgtgggaaattagtaggctcatttactgttttaggtctagcctatgtggattttttcct aaca 3908 NM_001607 ACAA1 taagggccagccttgaaagggatactagcctgcagtgggcatctgtcaccgtgtgtgtgcc caagtggga 3909 NM_001630 ANXA8 taacaaaataaactacaaattcctgacccaaggacactgtgttataagaggcgtgggctcc cctggtggc 3910 NM_001640 APEH ccctcaagacccggaatgtgcctgttcggctcctgctctatcccaaaagcacccacgcatt atcagaggt 3911 NM_001654 ARAF gctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaattttgtacggaagacctt cttcagc 3912 NM_001664 RHOA aaaggaccctggtgggccagacgggttggacatcgttaataatcatagttggcttctaaata ctggtagc 3913 NM_001712 CEACAM1 ctttctccaggaggattagcttggagttctctatactcaggtacctctttcagggttttctaacc ctgac 3914 NM_001715 BLK ccagcttgtcgcaagtaacgacacggaacagctcgaacgctcgtgactttattgcagaaa agccccgcag 3915 NM_001716 BLR1 cctcgcaagctgggtaatcgatgggggagtctgaagcagatgcaaagaggcaagaggc tggattttgaat 3916 NM_001728 BSG tggaacccggcacagtcttcactaccgtagaagaccttggctccaagatactcctcacctg ctccttgaa 3917 NM_001734 C1S actagggagggtgtgaggggcacggtgccatgtggggatgttggtgatatggccctgtgt gttatacctt 3918 NM_001743 CALM2 gttgcactattgcaaaacgggtgtattatccaggtactcgtacactatttttttgtactgctggt cctgt 3919 NM_001747 CAPG ccgacaacgaagcacgcacaaggaacgcaccagatcaaccgacagcagaacgcacg agagccaagaccat 3920 NM_001752 CAT ggcttcaaaatagagaatcccactttctatagcagattgtgtaacaattttaatgctatttcccc agggg 3921 NM_001753 CAV1 tcaccggggtggtttagtggctcaacattgtgttcccatttcagctgatcagtgggcctccaa ggagggg 3922 NM_001759 CCND2 atgatcagtgtatgcgaaaaggtttttaggaagtatggcaaaaatgttgtattggctatgatg gtgacat 3923 NM_001767 CD2 tttgactctacactcaaagccatctgatgctcacatttcatgtagtcagaggaggccatctgg tttgaat 3924 NM_001772 CD33 caaaatctggtacattcctgcaatgcatatcattcagacataaagatgggccgaagtacag atacatgct 3925 NM_001774 CD37 agctggagcgaagcttgcgggacgtcgtagagaaaaccatccaaaagtacggcaccaa ccccgaggagac 3926 NM_001776 ENTPD1 ccactgcagtttaatggatgagatgcccacttttaagccaaaaatactaagctcagactgga cctcctct 3927 NM_001783 CD79A ccagagaaacgaagtgagcagaactcgtaggaaaggctcgtgggtaaggagagtgcgc gcggtgactgca 3928 NM_001786 CDC2 ttcttatgccttggtcagagtaataactgaaggagttgcttatcttggctttcgagtctgagttt aaaac 3929 NM_001793 CDH3 aatgcctcccattcggatggatctctgcgtttttatactgagtgtgcctaggttgccccttatttt ttat 3930 NM_001794 CDH4 gcactgccaaagcttgtccgtgggagtgccacactcataactgccaggttccgacttctgt ccaccctag 3931 NM_001795 CDH5 gaccgaggttcccactctgggcaaagcccctcacactgcaagggattgtagataacactg acttgtttgt 3932 NM_001798 CDK2 cttccttttagtattcttagttgttcagttgccaaggatccctgatcccattttcctctgacgtcca cct 3933 NM_001830 CLCN4 ggaaaatattgagctaggcacattactctctgaacgaaattcatattatcttattaaggaaga gtgttgg 3934 NM_001838 CCR7 atcaaagccacactctgggctccagagtggggatgacatgcactcagctcttggctccact gggatggga 3935 NM_001839 CNN3 gtgtatctggtttctacatggaagactaaactcatgcttattgctaaatgtggtctttgccaact aaatt 3936 NM_001897 CSPG4 ttgaggccaacatgttcagcgtcatcatccccatgtgcctggtacttctgctcctggcgctca tcctgcc 3937 NM_001901 CTGF gtttttcggacagtttatttgttgagagtgtgaccaaaagttacatgtttgcacctttctagttga aaat 3938 NM_001905 CTPS gccatgaaaccagagacaaaatctctatactgccctgagttggggggaattctcagtgcca actgtggct 3939 NM_001908 CTSB gcagagaatcacgtcctggaactgcatgttcttgcgactcttgggacttcatcttaacttctc gctgccc 3940 NM_001916 CYC1 gggggccgaacttgaacctcaacacgacagccaacgtgcataagcatgcaacactaccg aggtagccaca 3941 NM_001923 DDB1 caagatgcaggaggtggtggcaaacctacagtatgacgatggcagcggtatgaagcga gaggccactgca 3942 NM_001928 DF caccgctatggacagagcgcagtagtgattagtcgtatttcgcgacacctcacacggtaga tgtgatcaa 3943 NM_001939 DRP2 aggtgcatgcgggcagtgatgggagaaggggaggcatgattcttctgaccctagaaatgt tccctttaat 3944 NM_001941 DSC3 tttgctcactcccactcaccgatcaaaacctgctacctccccaagactttactagtgccgata aactttc 3945 NM_001952 E2F6 gcagccttgctgttgagtcagtccaaggggttttacttaggacaagttgtaccttgccctctct ccagct 3946 NM_001964 EGR1 tttggcttataaacacattgaatgcgctttattgcccatgggatatgtggtgtatatccttccaa aaaat 3947 NM_001993 F3 tttgcacataacatgctttagattatatattccgcacttaaggattaaccaggtcgtccaagca aaaaca 3948 NM_001999 FBN2 cctgatcccactgctgttgaacagatcagcctagagagtgtcgacatggacagccccgtc aacatgaagt 3949 NM_002015 FOXO1A catgcctcctgcatttcgctacccgagtttagtaacagtgcagattccacgttcttgttccgat actctg 3950 NM_002017 FLI1 atgatgacatgtcgaagtctacccaatatcccccagtaagagaataaggggcaagaatga ctcatgaact 3951 NM_002023 FMOD tatagtttggctggggagcacttaattcttcccatttcaaaaggtaatgttgcctggggcttaa cccacc 3952 NM_002033 FUT4 gtaacctcttcaactggacgctctcctaccgggcggactcggacgtctttgtgccttatggc tacctcta 3953 NM_002046 GAPD acctcttttgccccccacacaaaagcccctttggtgtgaaaaacggcccccacaagtttata aaaggggg 3954 NM_002049 GATA1 tcatccggcccaagaagcgcctgattgtcagtaaacgggcaggtactcagtgcaccaact gccagacgac 3955 NM_002064 GLRX aacatctgataaaacttacagccccctacaccaagagtgtatctgtgaaagagctcctaca ctttgaaaa 3956 NM_002065 GLUL gccatgtacagtatgttcaaagtcaaataactcctcattgtaaacaaactgtgtaactgccca aagcagc 3957 NM_002068 GNA15 atggaatctgcagccgctccatggcctcgatcatggcccgcatggacacgaagatgttct ggtagaccag 3958 NM_002076 GNS atctcagtcatttgacttagaaagtgcccttcaaaaggaccctgttcactgctgcacttttcaa tgaatt 3959 NM_002086 GRB2 ctgcttctcttttcctcgcagatgataaaaggaatctggcattctacacctggaccatttgatt gtttta 3960 NM_002090 CXCL3 gaccttacattcacactttggatgttcttgaggtgaattccctgcagtgtctgcaagcactgg cagcgca 3961 NM_002094 GSPT1 atcagctaagctcccttggcgatctgcaggaacactagtaatgactggaattactccgtgat ctttgatg 3962 NM_002102 GYPE agtttcacaacatcctgtaacattggcttacctgtatattatatgccacccgtaaccataaaaa caccag 3963 NM_002107 H3F3A aggaggcaaaaccaaaagtttatgtggtgcttggggtggaccggtcggcggatgtcgtgc gttaattaaa 3964 NM_002108 HAL ctgagaggtgtcggatgctcttggctttaaggatcaatgtcttagccaaaggatacagtggc atttccct 3965 NM_002110 HCK caccaggaatcagggaggcaggctctgaggacatcatcgtggttgccctgtatgattacg aggccattca 3966 NM_002118 HLA-DMB aattattgtccaaggctatatttctgggatgaatataatctgaggaagggagttaaagaccct cctgggg 3967 NM_002121 HLA-DPB1 ggagcaagaaagttcaacgaggatctgcataaacagggttcctgacctcaccgaaaaga ctaatgtgcct 3968 NM_002128 HMGB1 gtcaaatttcctaactttgctgtgcaaaggttgagagctattgctgattagttaccacagttctg atgat 3969 NM_002129 HMGB2 aaaatgcaggttgtagctttttgatgggctactcatacagttagattttacagcttctgatgttg aatgt 3970 NM_002135 NR4A1 aggtttggcacccacttctccacaccttgagggctcggggatactggatacacccgtgacc tcaaccaag 3971 NM_002141 HOXA4 cttgcatttatttaagacactgttacagagatactgttgtcaccttctggggcacggtctttgg ggagag 3972 NM_002145 HOXB2 aaaatattgggcactcggttatcttttaaaattcacacagaaaaattccgtttggtagactcctt ccaat 3973 NM_002162 ICAM3 atttgcctcgtgagctggacgcttggcactgataagtaccattatgtgttacgttgacgaaga acgggat 3974 NM_002166 ID2 tacatcttggacctgcagatcgccctggactcgcatcccactattgtcagcctgcatcacca gagacccg 3975 NM_002167 ID3 aaggtcttttcagagcgtggaggtgtggaaggagtggctgctctccaaactatgccaagg cggcggcaga 3976 NM_002186 IL9R cagatgtgggcggcctgtgtgaacctgtcgtgcaaagctcacgtcaccaactgctgcagtt atctcctga 3977 NM_002193 INHBB cctctagatgtccaagtgccacgtgaactatgcaatttaaagggttgacccacactagacg aaactggac 3978 NM_002198 IRF1 agtggcagccaacaaacgtggatgggaaggggtacctactcaatgaacctggagtccag cccacctctgt 3979 NM_002199 IRF2 ttgcggttactctttaggccttgtctgtaaaacgaatggctcaggctaagtgatctctaaatgc ctaaat 3980 NM_002222 ITPR1 acccccgtgaaatatgcccgcctctggtcggagattccctcggagatcgccattgacgact atgatagta 3981 NM_002224 ITPR3 agttgtacgcccaggcaacaagggctgagctgcgcttgcgtggctgtttcatgaccgcttg tttttctcc 3982 NM_002228 JUN ttcaaagccgggtagcgcgcgcgagtcgacaagtaagagtgcgggaggcatcttaatta accctgcgctc 3983 NM_002229 JUNB actaaaatggaacagcccttctaccacgacgactcatacacagctacgggatacggccg ggcccctggtg 3984 NM_002230 JUP atagtagttaccttgcagggtcgttgtcaggttatgtgagaaaaaataagcagggcattgaa ttcactgc 3985 NM_002248 KCNN1 gtgggaatcagaaaaacctgttcccatcaccggcctagcctagaatcctagcctagaagc cctctctccc 3986 NM_002276 KRT19 aggggatgcgaaggacggggaccttaaccccgggtcttctcctgagctgccgaataaac ttttggtccca 3987 NM_002312 LIG4 ctagtgaggaaagcctctgatctggcagactcattgcagcaggtggtaatgataaaatact aaactacat 3988 NM_002341 LTB ccacatgaatggtagatgtaggcagcatgagtggttaagagtcaagggagtagccgggg tagtggcttac 3989 NM_002349 LY75 aacattttcccaagtgtgggaacattatttttagattgagtaggtaccttgtagcagtgtgcttt gcatt 3990 NM_002351 SH2D1A aagtacatgataagcgaggttccccgtgtgtaggtagatctggtctttagaggcagatagat aggtcagt 3991 NM_002353 TACSTD2 agaggagaggcgacagtcgcgagccacactttgcaatgaaactctttagactttctgccg ggagagcggc 3992 NM_002356 MARCKS ttaaactcaaccaagctgtgataagtggaatggttactgtttatactgtggtatgtttttgattac agca 3993 NM_002379 MATN1 agcgagccgcaggacgaacacgtcgattacgtggagagctacagcgtcatcgagaagc tgtccaggaagt 3994 NM_002388 MCM3 aggagtcggccacctacattgcagaagagtattcacgcctgcgcagccaggatagcatg agctcagacac 3995 NM_002390 ADAM11 ctaggttatgggtacggcaaccacatgtcccagatcgtctccaattcgaaaacaaccgtcc tgctgtccc 3996 NM_002392 MDM2 aaatgcacttcatgcaatgaaatgaatcccccccttccatcacattgcaacagatgttgggc ccttcgtg 3997 NM_002393 MDM4 acagaagtaatctgattagtcaaattattaagtgccatggattactttatgcagcagtcaggta catagt 3998 NM_002398 MEIS1 agtctatgttttagagctgcttaaaacaggaagtgatgtataaggtggtggttgttgcatggg gacaatg 3999 NM_002412 MGMT ggcgtggaggcaccgctgtattaaaggaagtggcagtgtcctgggaacaagcgtgtctg ccctttctgtt 4000 NM_002414 CD99 gggtgttctggtcgccgccccggatggtggtttcgatttatccgatgcccttcctgacaatga aaacaag 4001 NM_002415 MIF tctgtgcctctgcgcgggtctcctggtccttctgccatcatgccgatgttcatcgtaaacacc aacgtgc 4002 NM_002417 MKI67 tgcttccttctacgtaggccaacctcaaaactttcagtaggaatgttgctatgatcaagttgtt ctaaca 4003 NM_002419 MAP3K11 aggaaggctggaagcgcgagatccagggtctcttcgacgagctgcgagccaaggaaaa ggaactactgag 4004 NM_002421 MMP1 gaacacatgtgcagtcactggtgtcaccctggataggcaagggataactcttctaacacaa aataagtgt 4005 NM_002422 MMP3 tttatgttattacagggcattcaaatgggctgctgcttagcttgcaccttgtcacatagagtga tctttc 4006 NM_002436 MPP1 ttggagaaagcgtttttaactgcaactttctataatgccaaaatgacacatctgtgcaataga atgatgt 4007 NM_002441 MSH5 cttggtgagaattttctaacagatttacactcagagcctggtcgccccccgttagcccagatt caaaagg 4008 NM_002444 MSN aggctgagtagaagatcctaccccaattccttgtaggagtataggccggtctaaagtgagc tctatgggc 4009 NM_002447 MST1R agcacctcgcatgagatgaatgtgcgtccagaacagccgcagttctcacccatgccagg gaatgtacgcc 4010 NM_002460 IRF4 tgtaagttatgttttacatgccccgtttttgagactgatctcgatgcaggtggatctccttgaga tcctg 4011 NM_002462 MX1 tctctgcttatccgttagccgtggtgatttagcaggaagctgtgagagcagtttggtttctagc atgaag 4012 NM_002466 MYBL2 tgtctctgaccaactcccagttctctacagagcacgggaaagcccctcggggacgtctttc ctgcagtgt 4013 NM_002475 MLC1SA gtttccgcgtacgaacacctaaggatctactaaccgttcgcattctacttaacgcaggtcctt tctcttg 4014 NM_002483 CEACAM6 acacaggagattccagtctacttgagttagcataatacagaagtcccctctactttaactttta caaaaa 4015 NM_002512 NME2 taggtgatcacacacaccagccctgaacacgtgcggacaacgacacgcttcgcgcgctg ttggatgtaac 4016 NM_002514 NOV tggcatctgcacggcggtagagggagataactgtgtgttcgatggggtcatctaccgcagt ggagagaaa 4017 NM_002527 NTF3 ctctcaggagtcactctgtaaaatctgtgtacaccagtattttgcattcagtattgtcaaggcc atgact 4018 NM_002530 NTRK3 acggataactttatcttgtttgacgaagtgagtcccacacctcctatcactgtgacccacaaa ccagaag 4019 NM_002572 PAFAH1B2 gctacttgaactgtcaggggcatctgcctaaaccagaatcttttgtcagaaaccttaaccca acaaaaca 4020 NM_002576 PAK1 catgtcagccccattgactaccttctcatgctctgaggtactactgcctctgcagcacaaatt tctattt 4021 NM_002585 PBX1 tagaattttagaggcatagaagagagatcctaggtctagagactacaatccaaatagacta agttgggaa 4022 NM_002592 PCNA tcagacgtgtgaacggcacaccgacaatcacatggacaccccccaagaagtgatacgag ccaagccccca 4023 NM_002600 PDE4B agaaaggagcagtggtgtcgttcaccgtgagagtctgcatagaactcagcagtgtgccct gctgtgtctt 4024 NM_002608 PDGFB tggagtgataatattgtttccctcgtccgtctgtctcgatgcctgattcggacggccaatggt gcttccc 4025 NM_002609 PDGFRB agttggtccaaggagggagagtgggttctcaatacggtaccaaagatataatcacctaggt ttacaaata 4026 NM_002616 PER1 atctccaggagtccatgagaggctttcttctcctatgtcccaattctcagaactcagatgtgg ctagacc 4027 NM_002621 PFC agggtatatatttcggaggtaaaagaaagtagctcatgccaacaagtaacattcaccagca tttattgag 4028 NM_002648 PIM1 ctgttttcttcatcatgagttctgctgaatgccgcgatgggtcaggtaggggggaaacaggt tgggatgg 4029 NM_002658 PLAU attaggaagtgtaacagctgaggtctcttgagggagcttagccaatgtgggagcagcggtt tggggagca 4030 NM_002659 PLAUR ctgctaatgactgccagactgtggggaggcactctcctctggacctaaacctgaaatcccc ctctctgcc 4031 NM_002687 PNN caaaggataagaattcccggtccgacagaaagaggtctatatcagagagtagtcgatcag gcaaaagatc 4032 NM_002704 PPBP aacttctttaactcaccaggaagggtagaattttgaaacctgattttctatacgttctcatttatt cagg 4033 NM_002729 HHEX ttaaggggatagtacctcccaattcaagcagagaaactgacctgactaaagttaatcgcag atgaactag 4034 NM_002730 PRKACA acagggtctgccggggaagtttcaacattagccaggcggtgatgttcaccttgggatacca tggggccga 4035 NM_002744 PRKCZ gaaaaacgcccacgtcagggtgaccatctgtggtaaccgagaattccttggaggcagcgt cttcaccgcc 4036 NM_002753 MAPK10 ggtccatttcatgtgatctattactctgacataaacccatctgtaatatattgccagtatataag ctgtt 4037 NM_002758 MAP2K6 gctttcctttgagattggatagcaaaccatataagtagtattccttatcatggctgagaacata agaaga 4038 NM_002791 PSMA6 gatgtcaccctgtgctctcgtcacagactaacctgtcgtaggttaacagatcgcgagcaca cacgtgctg 4039 NM_002800 PSMB9 ataatatcaggcagttaccatacgagaaatcaaggtcgttgggacggaagtaaccttatct gcttttccc 4040 NM_002814 PSMD10 ttgtgataggagggatatttacatattttagtggaccacattttaagttggatggtgtgctctaa aatac 4041 NM_002827 PTPN1 aaaggcacaagatcacatttccagttaccctattacattgatatatacggccatgaaaagta gatggatt 4042 NM_002831 PTPN6 tgaccaactgcggggagcatgacacaaccgaatacaaactccgtaccttacaggtctccc cgctggacaa 4043 NM_002835 PTPN12 tagctgataaaatctctaagccacaggaattaagttcagatctaaatgtcggtgatacttccc agaattc 4044 NM_002844 PTPRK tttgtaattgactaaagcattccagtgtcctctttctagattgccagctcatgacatggtgcttat aaag 4045 NM_002856 PVRL2 ggtgtcacggtcacctgcaaagtggagcatgagagcttcgaggaaccagccctgatacct gtgaccctct 4046 NM_002868 RAB5B tcttcaaaggcccagtttcccctcacgcagcctcttaggtagcgtttcccctaatcgtgggg gttggacc 4047 NM_002870 RAB13 cttcaccccttatagttggctcgagagcatggaatccgatttttcgaaactagtgctaaatcc agtatga 4048 NM_002880 RAF1 ctttctccagaggcagaacacatgttttcagagaagctgctgctaaggaccttctagactgc tcacaggg 4049 NM_002887 RARS ggatgatggcagaaagattgtatttgtcccagggtgttccataccattaaccatagtaaaatc agatgga 4050 NM_002893 RBBP7 agagtatgttacatggcatataacggattgattaccttagatgtttgcacctaactgtatatga gcaaat 4051 NM_002901 RCN1 cttttcgactttatactctgagttattacttactgtaagtggtgtatatgaaacctccatgcatttt cca 4052 NM_002908 REL ggcagtatgcaaaatgagcaattgagtgactcctttccatatgaattttttcaagtataacttg caagat 4053 NM_002913 RFC1 cagaccagtaggaaccaggctgggtcaggctcttaatttcactatggtgggggacaaaat gaacactggc 4054 NM_002934 RNASE2 acccaaatatgacctgtcctagtaacaaaactcgcaaaaattgtcaccacagtggaagcca ggtgccttt 4055 NM_002935 RNASE3 agaggggcctgtgggttgagacactatagagtgtgtcataaccgagaccggatagggga gtagttacttc 4056 NM_002936 RNASEH1 aaaatggtggtattctcattctgtcgttttgcttgcctttattagctggaatggttttctaagaaa gtgt 4057 NM_002953 RPS6KA1 gagcatctggctgtttagcagaactcattctatccccaatcagctccttttccgttctgttctgc tggga 4058 NM_002960 S100A3 cgtccgaaacacccgaactggtcaactctcaagagaccatctggttcaggttcctgactgg gccagcgag 4059 NM_002961 S100A4 ctgtatacgatcgcatacaatcatgtctcacagcgctgatcttagcacattatgtcatgtttcc atctca 4060 NM_002971 SATB1 ggaagaggaccccaagactgcatcccagtctttgctggtaaaccttcgggctatgcagaat ttcttgcag 4061 NM_002972 SBF1 atgtggaccggctgagcaagaggacgcctgtgttccacaattacatgtatgcgcccgagg acgcagaggt 4062 NM_002975 CLEC11A cgaacgggtgtgctgatctcgtggacatgcttccgctccagctgttagcgacttgagctcgt cttcacag 4063 NM_002983 CCL3 tccaagcccggtgtcatgtaagtgccagtcttcctgctcacctctatggaggtagggaggg tcagggttg 4064 NM_002984 CCL4 tcgaattcataatatcgatggagcgggggagggagataataaaagaatagaagggttcctt cccccccac 4065 NM_002985 CCL5 ctgcatcaacacttcagattctacattaccactcaaacgcgaaacacaatcaaaatacccg agagaccgc 4066 NM_003002 SDHD ccggataaacaggtgtctaacgggcaatcgcctagaaacgatagagacagaacgcatgc gcgcaggcggg 4067 NM_003005 SELP ccttgccaacctgtgaggctatttcgtgtgagccgctggagagtcctgtccacggaagcat ggattgctc 4068 NM_003009 SEPW1 cgtttgcaagcgtatcacggatgtcacatcacactactcggatgacaatttcaacccgcaa aagaacaac 4069 NM_003025 SH3GL1 ccgaaagtcctggaccggtggctagcaatatcgtgtgttgcgcactcgtaaagtgtgttattt caaccct 4070 NM_003038 SLC1A4 agtccacagagtcggtagaccaggggttacgtgactggggaaaatctcacatctccttgtc tgaaaacat 4071 NM_003039 SLC2A5 tctgaaggacacggggacgttctcaccagcacatggtattaccggcctcgtcggtgtggtc tgtctgatg 4072 NM_003058 SLC22A2 caggaatacaacttaagtaatcatgaggtccttccatatttagattgggtaagcatgaatgtg tattttc 4073 NM_003072 SMARCA4 tggatgcatgtgcgtcaccgtccactcctcctactgtattttattggacaggtcagactcgcc gggggcc 4074 NM_003073 SMARCB1 acatgatcacggatacacgactctagccaccagtgtgaccctgttaaaagcctcggaagt ggaagagatt 4075 NM_003100 SNX2 tttatctagagctttgtctcagcttgcagaggttgaggagaagatagaccagttacatcaag aacaagct 4076 NM_003113 SP100 ccactaatctgtgactgctcctgtggaaactccacatcacaattctccaaaatttatcattgcc atttta 4077 NM_003118 SPARC cataatcctgcaagtactaggcgtggatatctggataatgaaggagtgtgaattaagaagg agtaccagg 4078 NM_003121 SPIB ccacaaagactgagttctcatggggatcctacccttcctagtgccactccctatggccatgc tgaagacc 4079 NM_003123 SPN ctcttcttgacgcttttcataatgtgcaaagtcatcaaagattgaggtggtatgcttgaaagta gcaatt 4080 NM_003127 SPTAN1 agcacgccaacgccttccaccagtggatccaagagaccaggacatacctcctcgatggg tcctgtatggt 4081 NM_003128 SPTBN1 tgaactgggacaggactatgagcatgtcacgatgttacaagaacgattccgggagtttgcc cgagacacc 4082 NM_003133 SRP9 caaggtgttaggtgtgactgtcacaactgttatgttttccagtaaactagaagtacgatatttg ataatt 4083 NM_003159 CDKL5 ctttcagctgcccaacccagcaatccgggttctctttcttcgtgagacacgttatgagggaa gccctgat 4084 NM_003189 TAL1 agcatttgggtaatttagattgtaaaccgctttggcctgagttattgagattgtcctcatttctcc agat 4085 NM_003200 TCF3 accctctttcaggtggattcagagacctgtcctgtatataacagcactgtagcaataaacgt gacatttt 4086 NM_003222 TFAP2C cttggaagattctatttaattgaaactctctgttcagaaagcaataactttgtctcgttcctgttg ggct 4087 NM_003225 TFF1 aaagagatcgatattataccaacctgtgcggcccaccgcgaagtcgtactccgactcggc cgccccaatc 4088 NM_003234 TFRC catcttcaaagcttgaagatcgttagtatctaacatgtatcccaactcctataattccctatcttt tagt 4089 NM_003262 TLOC1 tgaatcccttagaggtctgtgaattgtaggttaagaacccctgccctagctaatcagatcca ccaatgtt 4090 NM_003288 TPD52L2 cacttggagttgttttggttgcaggtgacagaaagcacgactcaaggtagcatcaaccaaa cagggaggt 4091 NM_003302 TRIP6 tctcagttccagttcccatcctttgattgatcactctccctgacatccacctgtatgactttgtca ccaa 4092 NM_003311 PHLDA2 ccttgattaatctttcaccgccccagcgcagacctgggaagcggaaaatcccgccgtatttt cccagccc 4093 NM_003315 DNAJC7 aaggcagttcagtttttcgtacaggctctcaggatggctcctgaccacgagaaggcctgca ttgcctgca 4094 NM_003318 TTK tgcatcttcaaatcactggcagattccggagttagcccgaaaagttaatacagagcagaaa cataccact 4095 NM_003352 SUMO1 actacgatactacaaacacaccacacaacccaactcaaaccacatcaatgcaatacatca acaaaatcac 4096 NM_003361 UMOD atgctgctttttctcaaaatgggacttgtgacggtgtacctgaggcccccatctccttaaaga gtgtggc 4097 NM_003383 VLDLR aaactaattttggtacgtatgaatgatatctttgacctcaatggaggtttgcaaagactgagtg ttcaaa 4098 NM_003390 WEE1 ctgtagtccggccctactcccacgtatccaacctagtctaccctagaatccactaacgcttta ttatgtt 4099 NM_003395 WNT9A agaccaaaaatgtctgctagctagttggtttctatacaaatacatattcgaatgtcttgctgga tgaaga 4100 NM_003403 YY1 gtctggtcagagttgctgagtgggttgatctctggtctttccttgacagtgcacgttcgaagg ctgtggg 4101 NM_003415 ZNF268 tgtatcggaagcatataccttggagggaccatgctatgagggaaagtgtaaatctagaaat gagaaaccc 4102 NM_003425 ZNF45 tgcagatctcgtggacaagtgtttatcaaactgaaggttgcagcttgttagtgggttcagaaa tcagttt 4103 NM_003427 ZNF76 gtatgccagcaaggttcttcatgacagccagattccccgtaatggaaaagggcagcaagtt ggagacaga 4104 NM_003453 ZNF198 accagatggttgtgtatgggtagcactactaaaagtttagaacttgcagtgtctttcggaattt ttaaaa 4105 NM_003467 CXCR4 actgtagaaaagggaactgaacattccagagcgtgtagtgaatcacgtaaagctagaaat gatccccagc 4106 NM_003480 MFAP5 ttaagaatatcttcacgaacttgaccctcctactccacattgcaacatttccatcagacagcat ttcaat 4107 NM_003549 HYAL3 ctacaggaggagagccactgtggtctgaagagatgctactgcctggagactggggtctta acctccagcc 4108 NM_003582 DYRK3 ggattccctctgaaaccctagatcggggtatatgttaagggattacgaaaatctaggactttt tgtgggg 4109 NM_003627 SLC43A1 ttctcagaccaagggacctggatgacaggcaatcaaggcctgagcaaccaaaaggagtg ccccatatggc 4110 NM_003636 KCNAB2 aagtccagtctgtgccggggaaggcactggttaggaaggatgttcaaacggtcccaccc aagcctgtcac 4111 NM_003645 SLC27A2 actgcttcggtatttatgcaactcaccacagaaaccaaatgaccgtgatcataaagtgaga ctggcactg 4112 NM_003692 TMEFF1 aagacagactttagtattctctatgtagtgccaagtaggcaaaagctcactcatgttcttattg cagcaa 4113 NM_003701 TNFSF11 ttggccaccaggtgcctttcaaatttagaaactaattgactttagaaagctgacattgccaaa aaggata 4114 NM_003707 RUVBL1 aagttatcgtaactgttcctgtggttgctttgaaagaacccttccttacctggtgtgttttctata aatc 4115 NM_003739 AKR1C3 aacagtcggtcttctatttcacacaagacttctcccgccgtattggttgcggaccttgcgcgg ccggagg 4116 NM_003746 DNCL1 cacaaagcgaggagtgacgcgataaaacgccgaacggaacacgaactgcgacactga aagaacccacccg 4117 NM_003753 EIF3S7 gagatgatattgaccttattgtccgttgtgagcacgatggcgtcatgactggagccaacgg ggaagtgtc 4118 NM_003801 GPAA1 aaagttacactgaggctccccccaccgatgctgcatacagatggtgtcgggcaccaacgt gtacggcatc 4119 NM_003805 CRADD gcctcttctaccttctaactccttgctttctaagccccaggtatctgataacttgattttgtcctg agtc 4120 NM_003821 RIPK2 ccatttttaacctcagccttccctactgtcaccaacaaccaagctaaataaagtcaacagcct gatgtgt 4121 NM_003824 FADD gtcgaaaacgcgctcttgtcgatttcctgtagtgaatcaggcaccggagtgcaggttcggg ggtggaatc 4122 NM_003842 TNFRSF10B ccagtcagtaggaaagtgccacaattgtcacatgaccggtactggaagaaactctcccatc caacatcac 4123 NM_003852 TIF1 ccaaacggtgcaacagaagggtaggttagatgctattaagaaggcacttaatagtacatca tgtaagatg 4124 NM_003874 CD84 ccatagactcatctagcaccaactaccattagcactatgttaggagctgcaaggccccaaa gtagaagat 4125 NM_003877 SOCS2 atgggaaacccacgggtacagaggactgaccatattaaagagttagggctactaacctca aaaagtttct 4126 NM_003879 CFLAR tcagggctccccctgcatcacatcaggaggatgttcatgggagattcatgcccttatctagc agggaagc 4127 NM_003884 PCAF acattagtatatgcgtccagggtcataaccccctaaaatccatcatgcaaccttattaatctgt cttggg 4128 NM_003900 SQSTM1 catcatcgaagtcttccccagttataaagaggtcacatagtcgtgtgggtcgaggattctgt gcctccag 4129 NM_003902 FUBP1 tcctccagcacctcagggccaataataagaagtggacaatacagtatttgcttcattgtgtg ggggaaaa 4130 NM_003914 CCNA1 gtaccttgatataccccatcgacctcagcaagcaattagggagaagtacaaggcttcaaag tacctgtgt 4131 NM_003954 MAP3K14 cttggtactgcagagtctgggttgtagagaactctttgtaagcaataaagtttggggtgatga caaatgt 4132 NM_003955 SOCS3 ttggggtgacctgaagggaaccatcctggtaccccacatcctctcctccgggacagtcac cgaaaacaca 4133 NM_003974 DOK2 tgtacgactggccctacaggtttctgcggcgctttgggcgggacaaggtaaccttttcctttg aggcagg 4134 NM_003998 NFKB1 tgtcattgctgttgtccctctgctacgttcctattgtcattaaaggtatcacggtcgccacctgg cattc 4135 NM_004039 ANXA2 caaagagaacgacgtcacgtccacaacccaaagcctcatgcgataccaggcgacatcat ctgtttatttc 4136 NM_004047 ATP6V0B gtgtgtccatcctggttagtcatatatctcttgtggtctgtccatccaaccatgtgctagatgtc atctt 4137 NM_004064 CDKN1B aagactgatccgtcggacagccagacggggttagcggagcaatgcgcaggaataagga agcgacctgcaa 4138 NM_004067 CHN2 actgcagaggatcgctgagtggggtactgtgtctcatagacatgcgccacctccacgtga gaacaagggt 4139 NM_004077 CS cccagtcccagaaccacactgttgagttggacacactgtaaacccctgggtaactgtcaag tcatgatgg 4140 NM_004083 DDIT3 gaccagggaagtagaggcgactcgccgagctctgattgaccgaatggtgaatctgcacc aagcatgaaca 4141 NM_004088 DNTT ggaagctcatcaaagcccactttgttcgcagtgtagctgaaatactgtctatctctaataaaa acaggag 4142 NM_004093 EFNB2 actcctcctcggaagagcccgtcgcgctggacagcttacctagtcttgtagcattcggcctt ggtgaaca 4143 NM_004099 STOM gcgggtgacatttgtaacatttcctctttgagactctgagttcacctagagaagtctaagcat aacagct 4144 NM_004104 FASN actttgtggtcttctcctctgtgagctgcgggcgtggcaatgcgggacagagcaactacgg ctttgccaa 4145 NM_004111 FEN1 gtaatttgtgtctagttattcagaggagtaagatggtgatgttcacctggcaatcagctgagtt gagact 4146 NM_004119 FLT3 catatctgagagcgttccagagccgatcgtggaatgggtgctttgcgattcacaggggga aagctgtaaa 4147 NM_004177 STX3A cccagtggtaaatcccttagatcccctgctggtctctggcagtctccttgattttgggtaccat gtatat 4148 NM_004208 PDCD8 caaagtggtcgtggggattgtgctatggaacatctttaaccgaatgccaatagcaaggaag atcattaag 4149 NM_004221 NK4 gatcccgcaaccgaggagcctaggggagagctttagtgacaaggtcatgagatggttcc aggccatgctg 4150 NM_004235 KLF4 gccaaagttttcaaactgctgcatactttgacaaggaaaatctatatttgtcttccgatcaaca tttatg 4151 NM_004310 RHOH aggaattgtcgaaaccgtggaaatctatttagctgaaatctagccagtgtgtagacaatgtt gaaatttt 4152 NM_004313 ARRB2 atcatcagagagatgatccgtctcctggatcagggtttaaacatcccagagaaaggggaa gttgctgact 4153 NM_004320 ATP2A1 gggcctcatgtcaactacagccagctgactcacttcatgcagtgcaccgaggacaacacc cactttgagg 4154 NM_004336 BUB1 agttctattctgcccacttattccagaatggcagtgtattagtaggagagctctacagctatg gaacatt 4155 NM_004343 CALR caccaacgatgaggcatacgctgaggagtttggcaacgagacgtggggcgtaacaaag gcagcagagaaa 4156 NM_004355 CD74 accatggagaccatagactggaaggtctttgagagctggatgcaccattggctcctgtttg aaatgagca 4157 NM_004374 COX6C gtgtggtatgcccaaaatggaaaagaggctattcagagtggtcagggagcttagaggagc gtaaaggaga 4158 NM_004380 CREBBP gaatgcacgtccaagaatacggctctgattgcccccctccaaacacgaggcgtgtgtaca tttcttatct 4159 NM_004385 CSPG2 tgagcatgacttccgttggactgatggcagcacactgcaatacgagaattggagacccaa ccagccagac 4160 NM_004413 DPEP1 atggtgaacttctacaacaattacatttcctgcaccaacaaggccaacctgtcccaagtggc cggtaggt 4161 NM_004425 ECM1 atacccttgacaaatactgtgaccgggagtatgctgtgaagacccaccaccacttgtgttgc cgccaccc 4162 NM_004430 EGR3 taaggtacttggttatccagtgcagtgcaccggaataaagagaatttgtaggcgtatacagc tttaaatg 4163 NM_004448 ERBB2 tggccatcaaagtgttgagggaaaacacatcccccaaagccaacaaagaaatcttagac gaagcatacgt 4164 NM_004449 ERG gaacgagcgcagagttatcgtgccagcagatcctacgctatggagtacagaccatgtgcg gcagtggctg 4165 NM_004454 ETV5 tgtgaagaggttcgcagggataaggggtgcactttatagctatggaaacatgagattctcct ctattgga 4166 NM_004475 FLOT2 tagagattatgacgttgcagccccgctgcgaggacgtagagacggccgagggggtagct ttaactgtgac 4167 NM_004494 HDGF tctctgaagccacaaataggatgcttgggaagactcctagctgtcctttttcctctccacaca gtgctca 4168 NM_004501 HNRPU tttgctgggtagtggagggggtaagctaaatcatagtttctgacaataactgggaaggtttttt cttaaa 4169 NM_004508 IDI1 tgctgtgcattgcaggatggtgagcagcgtccctctcatgtgacacccacagttatgccgg atgttgcca 4170 NM_004513 IL16 tggtgggggtgcagatgaggttgctagagaatgttagaggatccctctctggattggagat agggaaaga 4171 NM_004526 MCM2 cagttctgaggccctatgccatccataaggattccttgggattctggtttggggtggtcagtg ccctctg 4172 NM_004530 MMP2 cagcccacatagtgatggttcccctgttcactctacttagcatgtccctaccgagtctcttctc cactgg 4173 NM_004557 NOTCH4 aagaattgcaggcatatgggatgtaagatgttctttcctatatatggtttccaaagggtgccc ctatgat 4174 NM_004583 RAB5C taaggtggacgttttgaccgagtcgatgcgccgttcttgtgcctgtctacctgcgcgtttgct gtacgcg 4175 NM_004615 TM4SF2 tttaatgtagtactctgcttctgtatccccgaggtgagtcagaaaaatttcaagttgccacgcc ttggcc 4176 NM_004624 VIPR1 tacccacacctctgccagaagatcccctcaggactgcaacaggcttgtgcaacaataaat gttggcttgg 4177 NM_004633 IL1R2 atttcccccctcaagaccatatcagcttctctggggtcaagactgacaatcccgtgtaaggt gtttctgg 4178 NM_004642 CDK2AP1 ccgaacactttcatactaagactgtaagtagatctcagttctgcgtttattgtaagttgataaaa acatc 4179 NM_004688 NMI ttctctaaaagcacctacatcattgcttctacgcttgacgtggctctgagctcccaatctcctg ggacag 4180 NM_004689 MTA1 tgtcagtgagagatgttggaatatatggtccaatgaagcacatccctcgcgcccgacccgc cctggcagt 4181 NM_004706 ARHGEF1 acagactgtgtcggagcggaaaaactggtgtgctctcatcactgagactgccggatccct gaaagtccct 4182 NM_004725 BUB3 aacaaaaagcgactgtgccaattccatcggtaccccacgagcatcgcatcacttgccttca gtaatgatg 4183 NM_004815 PARG1 aagtccttaagttccaactctatttttgatccggattacatcaaggagttggtgaatgatatca ggaagt 4184 NM_004827 ABCG2 catctttaaaatgaataggtaggttagtagcccttcagtcttaatactttatgatgctatggtttg ccat 4185 NM_004867 ITM2A tttatttaccaactttgcaataacagaaagtccttccgccttcgtcgcagagacctcttgctgg gtttca 4186 NM_004924 ACTN4 tctcctgctctcataatgaagacatagccgattctctgcccgggccccttgctgatgctcctc cgggtct 4187 NM_004936 CDKN2B ggttcccttctctcaatgtttgtaataattgctcataagcaataccagcaattcataaaaactg cttact 4188 NM_004938 DAPK1 ttggtgcatagcagatggtttccacatttagatcctggtttcataacttcctgtacttgaagtct aaaag 4189 NM_004941 DHX8 ttcctgtggcaagtccacagtccgagtgcagaaggccatctgcagtgggttcttccgtaat gctgccaag 4190 NM_004972 JAK2 catcttgtgtgatgttttacacacatgagggctggtgttcattaatactgttttctaatttttccat agt 4191 NM_004994 MMP9 gagtgagttgaaccaggtggaccaagtgggctacgtgacctatgacatcctgcagtgccc tgaggactag 4192 NM_004997 MYBPH aatctgccaaggtgcccacagcagagcctcccggagaagtggcagtatcagagtccacc agagaagagca 4193 NM_005012 ROR1 aggagtagggccattgctagcccgtctctcactttggtgaaatttagaaaaaggcggttcct tttagaaa 4194 NM_005080 XBP1 ccagctgattagtgtctaaggaatgatccaatactgttgcccttttccttgactattacactgcc tggag 4195 NM_005084 PLA2G7 ctcaaattaaagggagacatagattcaaatgcagctattgatcttagcaacaaagcttcatta gcattct 4196 NM_005085 NUP214 aattgcccaaggaacgctcgagtctgcttgctgtgtccaacaaatatggtctggtcttcgct ggtggagc 4197 NM_005098 MSC agaggtctagacgtgagatccgcgtcgggacagggttttaagtgacaaagaagggcgag tggcttctctg 4198 NM_005104 BRD2 tacctgaggccatagctgccctattcacttctaagggccctgttttgagattgtttgttctaattt attt 4199 NM_005123 NR1H4 gggtctgcggttgaagctatgttccttcgttcagctgagattttcaataagaaacttccgtctg ggcatt 4200 NM_005157 ABL1 tgatagaaatggtttcctctggatcgttttatgcggttcttacagcacatcacctctttcccccc gacgg 4201 NM_005161 AGTRL1 gatgtctacactgccagagagaccgtgaggatgaaattaatagtggggcctttgtgagcta gaggctggg 4202 NM_005178 BCL3 aggaggggagaggtgggccgtaacgggcacggatcacgatgtaaattattaagcattttg gttggatttc 4203 NM_005187 CBFA2T3 gtgaatgtatatagtctttgcagaggtccaaatgatattcatgatggtaataaacgagatgttt gccaaa 4204 NM_005192 CDKN3 tttttatataccacgccacccatggggggtcttaacacgtgggggggcacccgataagca gctttcggta 4205 NM_005197 CHES1 cctgaagcccgatgacatcttacgaggtggacgttggactgttcatgcgcatcgggtgtca gtgactcat 4206 NM_005215 DCC acaatcagtggtgataggcttactcatcaaatcatggatctcaaccttgatactatgtattactt tcgaa 4207 NM_005225 E2F1 cgtggactcttcggagaactttcagatctcccttaagagcaaacaaggcccgatcgatgttt tcctgtgc 4208 NM_005230 ELK3 tctttaatgttgccaaacgctgccagtatttcatccgcctcacccttctcatctcggtccccgt ccctgt 4209 NM_005239 ETS2 atggggttcagcctaacagttatggaaactacagtccttataaaccattggcatggtaataa acagatct 4210 NM_005245 FAT catccactactcaattatagatggcaaccaaggaagctcgttcacaattgaccccgtcagg ggagaagtc 4211 NM_005246 FER ttcagaaagagctcactatcatcaagagaaaactcacatagtgacaggatggcgccaaac tcagccttca 4212 NM_005248 FGR gctcatcaccaagggccgaatcccctacccaggcatgaataaacgggaagtgttggaac aggtggagcag 4213 NM_005252 FOS tgtaatgttactgatcatgcattgttgaggtggtctgaatgttctgacattaacagttttccatga aaac 4214 NM_005263 GFI1 agagtgagaaccaagtgactccctaggcttcggacacaaataggctcctctacacctgaa gacaaaggca 4215 NM_005318 H1F0 cttttcttttcctctggatttttgttcctcctgtacaagaggtgtctttgcttggtttggtggggctg cg 4216 NM_005334 HCFC1 caccgttcactattgtagagtaacccctgtgactcaatattaccatagtgcgatgtcgttttgt gctatt 4217 NM_005335 HCLS1 tgctctgtagtatcctgtgtccataccagcctgtttctacattaaacacctatactcagcctga agcccc 4218 NM_005339 HIP2 tttcttcagtgtctacatattatgtcacacgttctatttgcactgctgcaatatagatcaaagatc ttgt 4219 NM_005340 HINT1 tgtgctgctgatctgggcctgaataagggttatcgaatggtggtgaatgaaggttcagatgg tggacagt 4220 NM_005356 LCK cccacatgtgacacatatgcaccttgtgtctgtacacgtgtcctgtagttgcgtggactctgc acatgtc 4221 NM_005375 MYB tgatgcaagatggccagcactgaacttttgagatatgacggtgtacttactgccttgtagca aaataaag 4222 NM_005385 NKTR aggagtactgtctcatctcatcatattcacgggttctggagattagctcattgaaagtgggag gggcatt 4223 NM_005424 TIE1 aagccaggaaggcctatgtgaacatgtcgctgtttgagaacttcacttacgcgggcattgat gccacagc 4224 NM_005427 TP73 ggattggggtgtccaaactgcatcgagtatttcacctcccaagggttacagagcatttacca cctgcaga 4225 NM_005439 MLF2 accctttgctattcaccgtcagcatatgagccgaatgctgtccggtggctttggatatagccc cttcctc 4226 NM_005494 DNAJB6 ccccacgggagcattgtagcacgcgctgtatggttgtgcgttgtagcgtgcgctgtatagtt gtgatgcc 4227 NM_005504 BCAT1 atgtttcctggggtgacttaacaaggaataatcccacaatatacctagctacctaatacatgg agctggg 4228 NM_005521 TLX1 cctgttgagtgacagtgtttcgcagctgagcccttaaggagattctcagttgggcagagac atcccttcc 4229 NM_005529 HSPG2 cctcggatgctggggtctacatttgcacctgccgtaatctccaccaatccaataccagccg ggcagagct 4230 NM_005533 IFI35 tcctatacctctatctgtcgtgcttaaacctctgctgctcgcgtactcgtcaccgtgcgcatca gtgagc 4231 NM_005556 KRT7 cccatctcccggccaaagctggtgccactgtctcagacccccttgtgagatctccagcaca gaatgttct 4232 NM_005563 STMN1 gtattttatgatagggataattcaggtcctaattttggtgttatttaaagggaccttattttctgcc cct 4233 NM_005572 LMNA gatcaagcgccagaatggagatgatcccttgctgacttaccggttcccaccaaagttcacc ctgaaggct 4234 NM_005583 LYL1 agtgacaaatcattccacacgataccccttgcattccagtagcgaaggttgttaccgccctc ctaccctt 4235 NM_005589 ALDH6A1 tagggaactgcctagtgtaacaatgaaaccagatttctcacttgctcttcatacttctattttga ggtaa 4236 NM_005608 PTPRCAP tccatttttaatcccgccaacgcacaatctccggaggaatgcccacgagctctcgcgttggt ggcgttta 4237 NM_005621 S100A12 gagcatctggagggaattgtcaatatcttccaccaatactcagttcggaaggggcattttga caccctct 4238 NM_005651 TDO2 ccacgatgctctgatttaattctagaaacaatttgattacctcttgtttgtgacaagactaagca ttaag 4239 NM_005654 NR2F1 aggagggccgagacaggagcagcccacccagcagaaatacaatccgagctacaaagc atgggaaaaagag 4240 NM_005671 D8S2298E taaaaacttggaagaagcttcaaagctcttggaggctttaaagttctttctgttgggtgtgcat tacagt 4241 NM_005687 FARSLB tgtgtgggtagagaccatcctttccctgcatattaggccagcttgtgccatataccagtgtgg tgtctgt 4242 NM_005730 CTDSP2 attcccacttgccccagagaagctactcggccaaacctagccagggtctgttcttgtggac cagagccag 4243 NM_005731 ARPC2 attaaagagggtgtacgggagtttcttggtaaatccagaatcaggatacaatgtctctttgct atatgac 4244 NM_005738 ARL4A attgaccagctaggctatttagtcccatagtagttcagatctgcttagatgtgacaggcattg aaggctg 4245 NM_005761 PLXNC1 tgtagtaacatgcagccgaaactcatgctgagacgcacggagtccgtcgtcgaaaaactc ctcacaaact 4246 NM_005767 P2RY5 actgtgatcggaggaagtgcacccgccgtttttgttcagtctacccactctcagggtaacaa tgcctcag 4247 NM_005781 TNK2 actttgggctgatgcgagcactacctcagaatgacgaccattacgtcatgcaggaacatcg caaggtgcc 4248 NM_005794 DHRS2 ttgtgagtatgccttaaattctatggggacaaggtaagaggacaagcaaatgaaagctcag agagacaaa 4249 NM_005808 CTDSPL gaattgaccagcggctgttacactgttctttgccactgtgcctatgctcagaatatgctcact gctaagc 4250 NM_005809 PRDX2 taatagaaaaagtcgaacacgctacagctaacttcttccgttatgagagcttgagactgcgc cgccgctc 4251 NM_005826 HNRPR aggccggacccatttgggatctacgtcttatgatgaatccactgtccggtcagaatagagg gtatgcatt 4252 NM_005835 SLC17A2 gtagccatatgttacagatctcagcaccgatcagaactgtaaagctataatccccagaatta aagttttt 4253 NM_005845 ABCC4 ccacactaaggaatcgtaccttctcagagtcttcggtttggtctcaacaatcttctagaccct ccttgaa 4254 NM_005870 SAP18 ttatgtagtagtatgatacctgtacttaagcatcactcaagggtaagtgttctaggaaggttga tttagc 4255 NM_005895 GOLGA3 ggcgtgttcatccccacaccgtgtgtcacaacaggctagggcacttcacgatgtcactactt gtttttct 4256 NM_005900 SMAD1 tcctgctattctgaaattgcctacatgtttcaataccagttatatggagtgcttgaatttaataag cagt 4257 NM_005902 SMAD3 gggctttgaggctgtctaccagttgacccgaatgtgcaccatccgcatgagcttcgtcaaa ggctgggga 4258 NM_005907 MAN1A1 gctgttcaggctatcgagactcatttgatccgcaagtctagcagcggactaacttatatcgc agagtgga 4259 NM_005911 MAT2A ctggtgcttatgctcttaattgccacctctaacagcaccaaatcaaaatctctccactttcagc tgtctt 4260 NM_005923 MAP3K5 attatacactattggatgttctctactatgttacacgtgatgacttaaaatgcttgagactaagg ggagg 4261 NM_005933 MLL cacccttttctcgccgcaagaagcccattcctatggaagtctagcaaagcaatacgactca gcccagcac 4262 NM_005936 MLLT4 gagaagataaagcttaccaacttgagcggcatcgaatagaggcagctatggaccgaaag tctgatagtga 4263 NM_005944 CD200 ggaggcaaatatgagcatacaatccctttgttctaaagatattgttccagctagtggaatgat gttgaat 4264 NM_005954 MT3 gcagaattccgtttttcaccggggcgtggctaccctgtcgtgacgcgtttccgcgtattgtcc cctataa 4265 NM_005956 MTHFD1 ttctgcccattcgcgacatccgcgccagcgttggggctggttttctgtaccccttagtagga acgatgag 4266 NM_005957 MTHFR gtgaaaacatcaccaatgcccctgaactgcagccgaatgctgtcacttggggcatcttccc tgggcgaga 4267 NM_005965 MYLK gcgttattgatgggcattaatctatgttagttggcaccttaagatactagtgcagctagatttc atttag 4268 NM_006005 WFS1 cctttctgagtgacatgggtgtgccaggctagactaggaggttccggtgtctggaaaagca ctttacaga 4269 NM_006017 PROM1 tacagcatattcttcacgcagagattttcatctattatactttatcaaagattggccatgttccac ttgg 4270 NM_006038 SPATA2 tctaaccaaccgtgatgccacgtaacttaccctatggacaaaagcaggaatgactaacac atcctaggag 4271 NM_006060 ZNFN1A1 ggtgtgtggagattctaatcccaacaagcaagggtctccttcaagattaatgctatcaatcat taaggtc 4272 NM_006079 CITED2 gcagatattactgcacaaactgccatctcgcttcatttttttaactatgcatttgagtacagact aattt 4273 NM_006082 K-ALPHA-1 tccacttgacagtcatcaatagattggtttaaattgtgatcttttttccttcccgcagcgtgagt gcatc 4274 NM_006084 ISGF3G ctttgtgataattctcagtagttgtccgtgataatcgtgtcctgaaaatcctcgcacacactgg ctggtg 4275 NM_006098 GNB2L1 ccaccacttacaagctggctgttgaaatgagagcggtttcttacagtctacccggcgttgtg gcacatgc 4276 NM_006101 KNTC2 ggagcagattgctaaagttgatagagaatatgaagaatgcatgtcagaagatctctcggaa aatattaaa 4277 NM_006113 VAV3 tgttatggagggagcagcctcacacaagcagaaacactcctgtggatggtattgtagcatg tattgttta 4278 NM_006120 HLA-DMA cacctgagctataccaacagtctcctaaattatttgctagacacatggctatttggatttaaatt aatac 4279 NM_006152 LRMP gccgctcccacacagcaagaggactcatggacgtctctagaacatatcttgtggccattta ccagactcc 4280 NM_006184 NUCB1 tcaagaccttcccctaccttttgtggaaccagtgatgcctcaaagacagtgtcccctccaca gctgggtg 4281 NM_006185 NUMA1 aaacaaagagctgcgagctgaagctgaacggctgggccatgagctacagcaggctggg ctgaagaccaag 4282 NM_006187 OAS3 tgggacatgcatgctatggggaccctcttgttggacacctaattggatgcctcttcatgaga ggcctcct 4283 NM_006190 ORC2L ggaacaatacgtcatatatttggaacagttattgtctgtgccatgaccttcatgataccagtga gaagcc 4284 NM_006191 PA2G4 aatcaggagtcaaaattcatcgtcttcaagcccctctttctagccttttctactactctctgcttg gtca 4285 NM_006196 PCBP1 ttgggcaagtttggatgcatctactcaaaccacccatgaactcaccattccaaataacttaat tggctgc 4286 NM_006209 ENPP2 cagaaatcctgacactcaagacatacctgcatacatatgagagcgagatttaactttctgag catctgca 4287 NM_006216 SERPINE2 tttaaaaaactcctgtcttgctagacaaggttgctgttgtgcagtgtgcctgtcactactggtc tgtact 4288 NM_006230 POLD2 tggcacattttcagcgttggctgagttacatgtacagtgcttaggccacctgggggagagta agagtggg 4289 NM_006231 POLE actgtcaggcgccctacgactcctctgccatcgagatgacgctggtggaagttctacagaa gaagctgat 4290 NM_006235 POU2AF1 aggtttgtaggagactgagttgttagcaggtgtgcttagctcttgatagtgaacgtgtacctt gggaact 4291 NM_006255 PRKCH aaactcacaacctaaagcccaatcttgaaaatatgttgtgcaccaagacgactgcttcagct tcttctct 4292 NM_006263 PSME1 acacaacccgcgttgtgaataattggttgtttgggccggtgaatacaccggccacgcaaca agtttacca 4293 NM_006268 DPF2 gaaaggagcaacacactgcccctaggcgtgcgtgtggcccagtttctctctgctctccatt aagtgcatt 4294 NM_006286 TFDP2 catgtaatattcttagaattgagattgctacacggagcagtccttgacgatcgtgtttctgacg tttctc 4295 NM_006299 ZNF193 ctgtagcaaggttctactgttttcagtttcatattacccctatatgcatcaaagctgcaacttcc cttgc 4296 NM_006301 MAP3K12 ctgcccaagccctgtcttaaggcccagggggaggttaggagactgatagcatgtgatggc tcaggctgaa 4297 NM_006302 GCS1 cttggtggaattggctacttctacggacaagggctggtattgccagacatcggggtggaag ggtctgagc 4298 NM_006325 RAN agccacaaacccaagcgaggaccaggacacaccacagccgatgtcgacacaaaactc agacgcaaagcaa 4299 NM_006329 FBLN5 tagtttgctttttgcgtacacagagaaggctatgtaaacaaaccacagcaggatcgaaggg tttttagag 4300 NM_006343 MERTK aaactcttagaaagtttgcctgacgttcggaaccaagcagacgttatttacgtcaatacaca gttgctgg 4301 NM_006355 TRIM38 agcggcagtcctggaggctaccagacttactgagttctacctgagaaacagccaagcaaa gtgtgagaga 4302 NM_006362 NXF1 ggtccccgagtacgatacaacccctataccacccgacctaaccgtcggggtgatacttgg catgatcgag 4303 NM_006427 SIVA ggtcgtgttgccttagggcccccatgtcagtgccgtcatctagactgattatgcccgcagtg atcctgtc 4304 NM_006472 TXNIP gcactttgttcactgtcctgtgtcagagcactgagctccacccttttctgagagttattacagc cagaaa 4305 NM_006495 EVI2B ctgagataatacaatcatttccaccgcttgactcacttaacttgcccctgccaccagtagattt tatgaa 4306 NM_006509 RELB tgaacagctctgacccccatggcatcgagagcaaacggcggaagaaaaagccggccat cctggaccactt 4307 NM_006534 NCOA3 caagggattagaccacctatggctggatgcaacagttcggtaggcggcatgagtatgtcg ccaaaccaag 4308 NM_006559 KHDRBS1 ttttgtccatttgagattctgcactccatgaaaagttcacttggacgctggggccaaaagctg ttgattt 4309 NM_006565 CTCF gtgtattgcttttaagagagccatcagttagctatcagactctaggttgatgcattttgtactta gctgt 4310 NM_006579 EBP gacgtggacaacttgtgtacctaagtgaccgccccacctgtggcttatacgtggcgtggcc tctttcttc 4311 NM_006591 POLD3 accttcaagtgacttccattatggctggacaggcggtgagctcagtggattgcagtggtgtg ctggtgat 4312 NM_006602 TCFL5 tctgcggaccgggtgaccgtgcttctgtggaatgggtgaatatacttctgcggaccaggtg actatgctt 4313 NM_006676 USP20 aagactctggactcattgctgattggaacaccaggaggaggttggatttctgccagtgggg gatgtttct 4314 NM_006739 MCM5 caccatcttgtcgcgcttcgacatgatcttcatcgtcaaggatgagcacaatgaggagagg gatgtgatg 4315 NM_006747 SIPA1 cgatggtttgcccactatgacgtgcaaagcctgctctttgattgggctccgaggtctcaggg gatgggga 4316 NM_006748 SLA gcagatgggtgccctgaatggaactactttaactaatccatagggacttctggtatgctttcc tctcttt 4317 NM_006759 UGP2 gagaatgaaaaacgaggaattggagatatgaatatcgaaaactcaagagttttgccttaaa gagaaaca 4318 NM_006762 LAPTM5 cacaactgggtcaacgctttaggctgagtcactcctcgggtctctccataattcagcccaac aatgcttg 4319 NM_006769 LMO4 tgcagcgcttgcggacagtcgattcctgcgagtgaactcgtcatgagggcgcaaggcaat gtgtatcatc 4320 NM_006803 AP3M2 aagtgtttaccgccacaagatcttttttgtggccgtgatccagacggaggtcccccctctgtt tgtcatt 4321 NM_006820 IFI44L tttgagtcttctctataagtctagtgttcatggaggtagcattgaagatatggttgaaagatgc agccgt 4322 NM_006825 CKAP4 aaggggagtccttgggttctttcaaaaaattcgtgaggagagctgtctacagtggaatagg gggtctccc 4323 NM_006845 KIF2C cctgtttcccggtctcgctatcaagatccaacgcagtaatggtttaattcacagtgccaatgt aaggact 4324 NM_006857 RY1 gcagtacatgaatcgaaaaggtggattcaacagacctttggatttcattgcatgagaattga agtgttga 4325 NM_006875 PIM2 tcccaagtgctcttattctggtgagaagaaccttacttccataatttgggaaggaatggaaga tggacac 4326 NM_006904 PRKDC tggagactggcggcgtgatcgggatcgactttgggcatgcgtttggatccgctacacagtt tctgccagt 4327 NM_006910 RBBP6 tggatatcatcgatctaggtcaaggtcacccccttacagacgctatcattcacgatcaagat ctcctcaa 4328 NM_006931 SLC2A3 tggaatcacccctagatctttcttgaagacttgaattagattacagcgatggggacacagaa ggtcaccc 4329 NM_006932 SMTN agagcacggactttgaagagcggaagctcatccgggctgcacttcgtgagctccgacaa aggaagagaga 4330 NM_006937 SUMO2 ccatgttaatatgcaagtatactagcagaaaaattgggccatagtatcgtggatttccaggta ttttctg 4331 NM_006938 SNRPD1 tgtacagctggaaacgctgagtattcgaggaaataacattcggtattttattctaccagacag tttacct 4332 NM_006963 ZNF22 ggccggcagcggcagaagtggggcatgactattcgatttgactcaagcttcagtagactc agaagaagct 4333 NM_006981 NR4A3 tccgtgttcgtactcccttttgtatgtttctactgttaatgccatattactatgagataatttgttgc at 4334 NM_007022 CYB561D2 tggtcatcatgaaccaggtgagcaatgcctacctataccgcaagaggatccaaccatgag ctcttcccag 4335 NM_007063 TBC1D8 gccctaaaccgagatttcagtctaccttaccaatggggcatctggctaaacaacctgacaa actgtggcc 4336 NM_007065 CDC37 aaatacgagaaacagatcaagcactttggcatgcttcgccgctgggatgacagccaaaag tacctgtcag 4337 NM_007079 PTP4A3 cctgttctcggcaccttaaattattagaccccggggcagtcaggtgctccggacacccgaa ggcaataaa 4338 NM_007117 TRH gagatgtgtacgcttatgtcggtgtcccaacgtataaactatcacagtagcgctcatggctc gtaggttt 4339 NM_012092 ICOS ataggttgctgtcagactatacccatggtgcctctgggcttgacaggtcaaaatggtcccca tcagcctg 4340 NM_012120 CD2AP tcatcctaataatgggatgagggaagtttccagcagatttcaggctgttcttaaagtttttgttg gtcat 4341 NM_012207 HNRPH3 ggaggttctggaatgggaggctacggaagagatggaatggataatcagggaggctatgg atcagttggaa 4342 NM_012223 MYO1B ttaggtgtatcaaaccgaatgataaaaaagcagcacacatcttcaacgaggctctagtgtgt catcagat 4343 NM_012267 HSPBP1 ttccataaggggggcttacacagttgccctaatgcggctggaatccccattgggggtaggt gagcaggca 4344 NM_012323 MAFF gaaactgctcttattgtgccaatatgccctccaaaccctcccaggattcaaagctaggtttgg ctgtctg 4345 NM_012334 MYO10 acacgaaaaaagaaatttgccttgtccctttgtgtacaaccatgcaaaactgtttgttggctc acagaag 4346 NM_012384 GMEB2 gaggcataaacagaaccagtcactatggaggtcgaggattcccatgtgggcccttcagct tgggctgctt 4347 NM_012417 PITPNC1 tgagatatccaggagattcattaggtcatcagcgatcaaaggttagcattttattatagatgtt cactgt 4348 NM_013282 UHRF1 tgttctacaggggcaaacagatggaggacggccataccctcttcgactacgaggtccgcc tgaatgacac 4349 NM_013314 BLNK ttgttctattgcctgacctgatgaactgttaatatctggtgaggttgagttatcatgctactaata tttt 4350 NM_013416 NCF4 gcggtagatgaggtacttggatcctccttttgtcttcacctcgatgacgaaaacctaaggag gacagagg 4351 NM_014005 PCDHA6 tacagatgtcatttgtctcccgccctaagtcctccagtctccttagagctagtacttactaagc atttac 4352 NM_014207 CD5 cttgacgaaaacagactcctctagtacttggagatcttggacgtacacctaatcccatgggg cctcggct 4353 NM_014232 VAMP2 tgaggaagggtctattgtctttttaaatggcacaattttaagggtttgagggtacagtccctta acctgc 4354 NM_014244 ADAMTS2 tgaatttgtgaacaatacaccctctccgcccttggggtaatgtactttgtgatattgccacccg cccccg 4355 NM_014298 QPRT tgggtctaataaaggatcaaccacatggggttctgcggtgataatgagcacatagtgaggg gtcagcaaa 4356 NM_014345 ZNF318 acttttagaagacgacaaatcggtaaggcttattcatggttcattgccaggagcagatatgct tttgaga 4357 NM_014365 HSPB8 gcctaaaatgggtgatatacaggtcttatatccccatatggaatttatccatcaaccacataa aaacaaa 4358 NM_014575 SCHIP1 caaaacagcaccagcaattatgtgacctgctttcgatcataagactgtgttaagaccttctcc tcagtgt 4359 NM_014595 NT5C gtgtggtttcccccggaaagatgattttgatcaagcacaggtaatcaggactgtcctcagga ctttatgt 4360 NM_014614 PSME4 ttgcagattcacatgaaagcacccagcgatgtgttgcagaaattatagctggtttaatcaga ggttctaa 4361 NM_014624 S100A6 gcagtctgatcgatcgcgatgtaagtcgcgagccggcaatcgcgtgtgcacatactcgca gatccttctc 4362 NM_014667 VGLL4 gctgcctgcagtgcgctctgaccttctcttcatgtgtgtaaatctgtaatataccattctctgtg gcctg 4363 NM_014707 HDAC9 ctggtcacgactgcaagaaactgggctgctaaataaatgtgagcgaattcaaggtcgaaa agccagcctg 4364 NM_014724 ZNF305 tttctgtaaatttgagactacctttatattctccaacacaagaccgtgtaggtgtcccttcagag agtat 4365 NM_014734 KIAA0247 atgtcgcctccatttccgaggaacatccttgcgtagagaatgaaatatgctgcaatcatttct gcatcct 4366 NM_014735 PHF16 atgtttcaagtctagtttttacaagcacattacagtaattgcaggttgtccagaggttggtttgt cagag 4367 NM_014780 CUL7 agatggcagcaaggaacccaggtcgagatgggacattgtgcggctcatcccacctcaga cgtacctgcaa 4368 NM_014792 KIAA0125 attcacatgaacgggcacatacaggaaaacacggtaatgtaattagaatagtcagagaaa agtagccaga 4369 NM_014824 FCHSD2 ctgtccgctcctgtagaaggtagggagcacaatacctagggactaagggatgttcgccgg ttgtggtttg 4370 NM_014890 DOC1 cagtttcagcgttcaaacagcaatagctcaagtgtgataactactgaggataataaaatcca cattcact 4371 NM_014899 RHOBTB3 cctagacatggaaaaacagattactgtctattgtcagcatcattttcatctgtaagtcactact ggaata 4372 NM_014914 CENTG2 ctaatacatggagttgtgcttcctaagtattgatagcggcgtatatataggattcccacaattt gcagtt 4373 NM_015050 KIAA0082 tttttcttccctaataggaggtacaatctgcttttgtttgtcgttaagtggtcactcccatttccttt at 4374 NM_015069 ZNF423 catttgcaacccagatgtaaaactctaatgatttggccatgaggcgctgctattataagcag ctggaaat 4375 NM_015099 CAMTA2 ggctccacgggcactttctacttgtgcatgggcttggtttatacgaattgccattaaacatcg ctgcacc 4376 NM_015147 KIAA0582 taaggcatgctgaaatttgttgtaaatcccaatctttactgccatggggaaaagaacgctgg aattttcc 4377 NM_015149 RGL1 tgtttcctggtggacagccgggtaatgcttttagctgctcgcatgcttgtctttctgcatctcca tcatc 4378 NM_015158 ANKRD15 atgcccatgtcaactttgcaaaagcccagtctccgggcacccctaggcttggaaggaaga cgtctcctgg 4379 NM_015166 MLC1 ctgatctgagaagacatgaacgttttctcttcaccgccgtggggtgtattgactggtccccc atgggctg 4380 NM_015196 KIAA0922 tctggactttttggttccatctgggccccgcaaagcgatgtgtatgaaaattgctgccccatc aacccca 4381 NM_015210 KIAA0802 ctccggaggtccatctccgagatcgaagaccacaaccggcaactgacccacgagctcag caagtttaagt 4382 NM_015261 KIAA0056 agtggtctctagaggtgatcagttcagctgttgacgccttgcagaggctttgtagagcatct gcagagac 4383 NM_015335 THRAP2 ccagattgcaaagagttatggatattctggtggggagatgaacccaacctagtgggtgtaa tacatcatg 4384 NM_015436 RCHY1 aaatatgtttgatgatccagccgactttgacactgttatctccgtaatagctttaccattaggct aggat 4385 NM_015458 MTMR9 aacttgtgagggagtttgtattaggtctggtcatggagggatgatgtaccatcaaggtagac ccatcttc 4386 NM_015474 SAMHD1 gatttattccacttgctcgcccggaggtgaaatggacgcatgaacaaggctcagttatgatg tttgagca 4387 NM_015528 RNF167 tgatgaaggggagccaagggaccaccctgcctcagaaaggaccccacttttgggttctag ccccactctt 4388 NM_015568 PPP1R16B ctcagccagaacctcttggtgtacccgataagctgcaggttatcccttgctctgtgcgccttt tatttgt 4389 NM_015570 AUTS2 caagtctgggaacagccgtaacaggtcaaccttgtggagccatcgcgagttagagggtg aaagatggcag 4390 NM_015636 EIF2B4 gcggggagaacatgttgcgctggctaactggcagaaccacgcatccctacggttgttgaa tctagtctat 4391 NM_015670 SENP3 cgctgccctaagcatattgccaagtatctacaggcagaggcggtaaagaaagaccgact ggatttccacc 4392 NM_015710 GLTSCR2 cgtgagatccagttgtagctgccatcagatgccggagactcgcccttcaataaaaaatctct tctagctg 4393 NM_015833 ADARB1 atgaactgaacggttaaaagcacagtctatggaacgctaatggagtcagcccctaaagct gtttgctttt 4394 NM_015855 WIT-1 gctccccgagagtcctcagtgaaaggattccgcggcactgcctctattattataccgtaaat ctttttaa 4395 NM_015869 PPARG aataaggaggttctttatggaataaacaggtattaagctatttaaaggagagggctgcgaaa tgcttgat 4396 NM_015965 GRIM19 aaatcgaggacttcgaggctcgcatcgcgctgttgccactgttacaggcagaaaccgacc ggaggacctt 4397 NM_016041 DERL2 taacatacctccaacaccgtcatacatatacctccgctacgcaaccttacctagttacgccc caattgta 4398 NM_016091 EIF3S6IP ttcgctctttccggcggtgctcgcaagcgaggcagccatgtcttatcccgctgatgattatg agtctgag 4399 NM_016184 CLECSF6 ttcttattcatgtgtaagggaggtccatagaatttaggtggtctgtcaactattctacttatgag agaat 4400 NM_016195 MPHOSPH1 tggcagtgaaacaccctggttgtaccacaccagtgacagttaagattcccaaggctcgga agaggaagag 4401 NM_016221 DCTN4 atgataacccaaaggtagacctgctgttaatgatccagcattggtcacaatgtaccaactgc tttctgca 4402 NM_016308 UMP-CMPK caagagtaaagactaaggtttcgagagcattcctactcacataagtgaagaaatctgtcag ataggaatc 4403 NM_016343 CENPF gctggagatagaccttttaaagtctagtaaagaagagctcaataattcattgaaagctactac tcagatt 4404 NM_016570 PTX1 aagttacttaaacctgagctttaggacctttaaaatctcagcatgccttttaagctagtactttt cctgt 4405 NM_016734 PAX5 aggcccaataatatttggaccaagtgggaaacaagaacactcggaggggcgggaatca gaagagcctgga 4406 NM_017437 CPSF2 ctttctgtatttgcgtctttcttgtgactaaccaccctgatatagtattaaccactgtgttcaaga gtaa 4407 NM_017448 LDHC tgtgtcttggggcggaatggtgtctcagatgttgtgaaaattaacttgaattctgaggaggag gcccttt 4408 NM_017617 NOTCH1 tgtcaaacatgagatgtgtggactgtggcacttgcctgggtcacacacggaggcatcctac ccttttctg 4409 NM_017771 PXK catgagccgaggggccttgctcagctccatccagaatttccaaaaaggaactttgaggaa agccaaaacc 4410 NM_017787 C10orf26 ttcaatgacaggcttggactagctgtggcccagacatcggccctgcccagaattgccagg aggaggcttt 4411 NM_017794 KIAA1797 tgacagcttgacacatgcctcctaagagaggagtgcattgctttagtacccgggccagttg agactgaaa 4412 NM_018136 ASPM agagcctctgatgtacgaagtaggtccaaagttgttgaccgtatttacagtctctacaaactt acagctc 4413 NM_018209 ARFGAP1 gagctgtcagcgacgtgaggtgtcccttctcgttgagatatttaactttggttttgctctagttc tttct 4414 NM_018248 FLJ10858 gcaagctaccgactagaaatactataatcagttggacatctagcagggtggatcatgttatg gactccgt 4415 NM_018462 C3orf10 agcccttgaacggagaatagagtacattgaagctcgggtgacaaaaggtgagacactca cctagaacagt 4416 NM_018664 SNFT ctcctgggcaaggggctgttgtgagcccattggtatagcaactagtggtgctgtctactgca aagcaaat 4417 NM_018951 HOXA10 gaggactggggtaagcggaataaactagagaagggagacattgtttggatttcctttatact gtgaagtt 4418 NM_019028 ZDHHC13 ttgtccctcaggaagacaccatacaatcttggattcatgcagaacctggcagatttctttcag tgtggct 4419 NM_019071 ING3 tgcagttcatgagggagggggcgggggactgaaggggaaagggcgttaaagtgataca tttttataccaa 4420 NM_019102 HOXA5 atggagatcatagttccgtgagcgagcaattcagggactcggcgagcatgcactccggc aggtacggcta 4421 NM_019111 HLA-DRA acaaagcgctccaactatacttcgatcaccaatgtacctccagacgtaactgtgctcacaa acagccctg 4422 NM_019841 TRPV5 tgcctatgcaagtgtctaacttctgtgcctgttaatcatgggagggtgagacagaacaatcc ctaaaggg 4423 NM_019846 CCL28 catcaggggaaacacgaaacatacggccataaaactccttattagagagtctacagataa atctacagag 4424 NM_019857 CTPS2 acaacgacccccgcgttttccccgtactagatggttagggcgcatagtgccgaactacgct gctgctaca 4425 NM_020310 MNT ctgcaaatctagtgccgaaatctagtgccgaatgactatgtccagattggtgacgatgggt gttgctgtt 4426 NM_020368 SAS10 gcttagggaaatttcacagttcattgtggagtgttaaacttagaacatgtgtaacttttcacata aagag 4427 NM_020371 AVEN ggctgtccttcaggaccagccagtttacaagcatgtctcaagctagtgtgttccattatgctc acagcag 4428 NM_020657 ZNF304 acaaaaggagattcgaacattctagaggggacatccacaagtctcggtgcagttatgatg gtgtgggatg 4429 NM_020841 OSBPL8 gtgaagcggttggatccattactcaacccttacctagcagttatttgatcatccgagctacttc agagtc 4430 NM_020843 ZNF291 tgtttagtaacaagattaccttcttaatggacctcctgatacaccagttgacggtttatgttcca gatga 4431 NM_020892 DTX2 agcaggtctgcagtgatcagatgggtttctcacatattgttaagttgaaagtagccgtggctc agtatga 4432 NM_020944 GBA2 aggggccatgggggctgtgaatgggatgcagccccatggtgtccctgataaatccagtgt gcagtctgat 4433 NM_020956 PRX cacagctgcccgccgtggaaattgaggaagggcggctggagatgatagagacaaaagt caagccctcttc 4434 NM_020998 MST1 cccctgaatgaacaaagtgtggacatgccaatacacattactgacaggtatgcccacctga cctgcaccc 4435 NM_021019 MYL6 gaaaggcgagcaaccagaacagagcacaacaaaggacgagcagcgccagccgagac gacgtaaggacaca 4436 NM_021038 MBNL1 ttaatgcgaacagacagacttgaggtatgtcgagagtaccaacgtggcaattgcaaccga ggagaaaatg 4437 NM_021071 DO gcatctctctcctttttgaccagtgtcatcatcttttccaaaagcagagtataaagaaatcttgt ggctc 4438 NM_021103 TMSB10 ctgggggtgaaatcttacagcgcgggttccgttacctttcccggatacttttccgggaatgat gtacaca 4439 NM_021111 RECK tacagataattacctactctggctagaagctaggggtcccagtgaagagccactgccatta aagaatatg 4440 NM_021114 SPINK2 tacgctcacccacctcactatactctcccttatcgcgcgtctatatggccccgatcacccttc cgccttg 4441 NM_021643 TRIB2 ccgcccgagactccgaacttgtcgcattgcgtttcttgtatcgggaaatacttattgttggaa cctctgg 4442 NM_021814 ELOVL5 gcagtgtattacttatgtgtttgtggagatgttggtgtaaacctactgcactgctaattctataa aagta 4443 NM_021906 USP9X taacttacatggaaagcatgagactatatgctagagaccatgaagattatgacccacaaac tgtgaggct 4444 NM_021949 ATP2B3 ttgtaaactgttccctgatgtccttgtttaaacgataataagaaaaagggcaactccatttgtt gagggt 4445 NM_021960 MCL1 tctggttaaacagctgtacttttgatagctgtgccaggaagggttaggaccaactacaaatta atgttgg 4446 NM_022067 C14orf133 ggttgtcgaaattttgcacaagaacaatgcccctgtgcagatattacaggagtatgtcaatct ggtggaa 4447 NM_022127 SLC28A3 atcgggtccctaggaatcgtgatcggcggactcacgtccatggctccttccagaaagcgt gatatcgcct 4448 NM_022161 BIRC7 catttctgctgcaaacctggtcagagccagtgttccctccatgggacctaaagacagtgcc aagtgcctg 4449 NM_022334 ITGB1BP1 aattggagtttactgtcatctgtttccgtttctctaagatagggatcctggcgaagcccatgaa agccat 4450 NM_022366 TFB2M tatgatgaaaccctggaagataggtagcaactagactgtcgtttttggtggagcggttcattt atttgga 4451 NM_022436 ABCG5 ccagagttaaatgcagatgtccacacgaggggtcggagttacctgatcacatcgagagag tgctgggcag 4452 NM_022438 MAL aaatcagtgcaatgaagactttggatttattaaaaccaagttgtccctaaggaatcagatgtg ggcatct 4453 NM_022469 GREM2 tagcaatgaaagcaatatgatatgctgcagtgtgaagctccttctggggttatcgtatgtaca aagttta 4454 NM_022549 FEZ1 atgcagattcctggtatcacttgctcgctactttctagggtcttaatagtagtcaagaaaagg gatctga 4455 NM_022716 PRRX1 ggaattgcagttagagagagtaaggaataccatttagtcatctatccgttcttcacttagcag gaatatg 4456 NM_024006 VKORC1 caatgatcagctcccgcgactgctacgtgctcattagtgttcgtccgacgacgaccgtcata tgtccacc 4457 NM_024319 C1orf35 ataccagggatggcccctggcttggcctgcgaaggtgaacctgcccagatttatcagtag aggctggact 4458 NM_024408 NOTCH2 ctgtttgtatgagaaacccagtaaccaataaaatgaccgcatattcctgactaaacgtagta aggaaaat 4459 NM_024424 WT1 ctacaagacactgcccccacgctctctgctcagtcctctcccacacgatctatccctaaacc tttcgcgg 4460 NM_024713 C15orf29 tgcacgtctgtgatttgagaggtgagttatttaagaggccagttttcaggacatgggaatttg aattgta 4461 NM_024728 C7orf10 tccagaatggctctggtattaatgaatctagtgccttttaaatgtatcccacgttttgttccctac catc 4462 NM_025263 PRR3 gcctttctcagtgtccgtggcatttttgtgacttcccagcactagaataagttttcctgccaaa atgagt 4463 NM_030660 ATXN3 acagttgagtcatggaatgtaggtgtctgcttcacatcttttagtaggtatagcttgtcaaaga tggtga 4464 NM_030674 SLC38A1 cagatgggtgatttaagtgagtcacaagtcacaaaactttgctattcatagttaatcaaatag aactggg 4465 NM_030915 LBH tttcagtaaaaatgcctgttgtgagatgaacctcctgtaacttctatctgttcttttttgaggctc aggg 4466 NM_030926 ITM2C cattcgatatgctaaccgttctcagccctgagccttggagaggagggctgtaacgccttca gtcagtctc 4467 NM_030935 THG-1 cccacgatgccagcctggttcacaaatctccagaccccttcggagcagtagcagctcaga agttcagcct 4468 NM_031243 HNRPA2B1 gacagtttcttagctttttaattgttgtttctttctagtggtctttgtaagagtgtagaagcattcct tc 4469 NM_031423 CDCA1 gagactgctgatattctatgtccaaaagcaaaacggacaagtcggtttttaagtggcattatc aacttta 4470 NM_031966 CCNB1 ccttttggtttacctggggatccaattgatgtatatgtttatatactgggttcttgttttatatacct gg 4471 NM_032121 DKFZp564K142 atgaatggagacaagttccgtcgccttgtgaaagccccaccgagaaattactccgttatcgt catgttca 4472 NM_033238 PML acagaaactgatgttccatgcatgttcctgcttccaaagcctgaccttccaaagcttgcttcc ttcctcc 4473 NM_033512 TSPYL5 ggatgcctagttgaggatgttcccaaagttttgtccaatcttatcattagtagattttataagcc acaga 4474 NM_033554 HLA-DPA1 ccccacactcgcgagaacgaccaaaaatgaaacgaatacggccggaaaccgatcccat gtgccgggccaa 4475 NM_033642 FGF13 ccaaacaaacaggcagagttcactattctatctgccattagaccttcttatcatccatactaaa gcccca 4476 NM_057168 WNT16 ggataagatccttgaatatggaacttagttacaggactcaataatggtgggtgaacattagt cattttta 4477 NM_058195 CDKN2A gctcttctgttcctgcgacacctctgttctatgatcttcgctcttgttgtttctcaccatgtgtcag ctg 4478 NM_080284 ABCA6 acgacaggagtctagttccactgtggaattcctttctggttgtacatttgctaggtagtgacaa ctaatg 4479 NM_130439 MXI1 cctcactctttatagtgcacaaaatgaatgaggtctgggctaggtagaaaaagggtcaatg ctatttttg 4480 NM_133259 LRPPRC atttccaatcagtttgattgggctctaatgagactagatctttctgttcgaagaactggccgca ttccaa 4481 NM_133378 TTN cagtactacctgggttgagttagcaaccaccgttatacgtactacctataaagccacccgc cttactact 4482 NM_138714 NFAT5 tccagtaaaaaactcctgcactgaagtcattgtgacttgagtagttacagactgattccagtg aacttga 4483 NM_144578 C14orf32 cctggataaaggcactttcactgcctgtcactgatcagcagatactgacttgttgccattaag tgaactt 4484 NM_144628 TBC1D20 actaatcacctcttctgtcattccgtccttggccaccgctcagtgggaatggtctctgatctg gatgctc 4485 NM_145698 ACBD5 ttacaagcagtctgggataactaactcctagggataaccatttctatcctgttccaaagtctta ttttat 4486 NM_147180 PPP3R2 gtggcaatgaccttgaactgagagcctgtatctggatttagcacttgaaagatctaactgga tatttggg 4487 NM_152739 HOXA9 ttgaatattgtttttgcaccagacgaacagtgaggaaattcggagctatacatatgtgcagaa ggttact 4488 NM_152788 EB-1 ggttgatgtatttagcttgaatccttcactttagtggtctaatcaacagataaatgacaagcaa agaatg 4489 NM_152827 SNX3 agaaagtatcttcctccaggcttgtaatacccttcacatggaagattaatgagggaaatcttt atattct 4490 NM_152890 COL24A1 acccagcacgaatctgcaaagatttacttaactgtgaacaaaaagtatcagatggaaaata ctggattga 4491 NM_173156 C1orf16 agtctcccagcctccactttcagagtgaaattcaaggcagcacggacatgtgcccatcag gcacagaaga 4492 NM_173216 SIAT1 ggtggcattccgacagcaggacatacatgttggtgtgaagactgggacgacactgggtag aatctagttt 4493 NM_173609 C15orf21 actgagatagaaggaccagccactttgaacgccttagaggcaaaaagagctttgtgagtt gtaagaggaa 4494 NM_173852 KRTCAP2 agagagccccggatttctcctggactccatgtgcagatgcctagtatttccattctgaccgtt gccctcc 4495 NM_175739 SERPINA9 ctgagaaagtggagccactcactccagaaaaggtggatagaggtgttcatccccagatttt ccatttctg 4496 NM_175744 RHOC ttgttttcggcaggggccttgtctctcactgcatttggtcaggggggcatgaataaaggcta caggctcc 4497 NM_178586 PPP2R5C ctgtacatcagaaatgtcactattccaagtgtctttttagtgtggctttagtatggcttccttttaa tat 4498 NM_181311 TAZ accagggaaagtgaacatgagttccgaattcctgcgtttcaagtggggaatcgggcgcct gattgctgag 4499 NM_181336 LEMD2 atgtctggatgatcggcagggcaggaatctgagcgctggccccgtggtgaggccatgttc tcataatcag 4500 NM_181339 IL24 cctaggcaaagagtatatgtaggaggtgggatatcacttccatgacataagtgctattgcag agccgtgg 4501 NM_181430 FOXK2 tggtatgtttgtatttggggtgtccctccggctctaggcggcctctgacctgctgtctactccc cacctt 4502 NM_181493 ITPA tggcttctgctgtcgtgtccatccttccttcgtctggctcgtgattcacttattcgccctccctac tttg 4503 NM_181702 GEM tgtggtttcccccattgtagcagggagctagcgtattagccttgtgggcaacatgatgcatg ggaaatga 4504 NM_182729 TXNRD1 gctggtctaagcaagctgagatcatttgcaatggaaaacacgtaacttgtttaaaagtttttct ggtagc 4505 NM_182810 ATF4 aaaagggtcccctagttgaggatagtcaggagcgtcaatgtgcttgtacatagagtgctgt agctgtgtg 4506 NM_183395 CIAS1 agacaccaggacaatgacagcatcgggtgttgttgtcatcacagcgcctcagttagagga tgttcctctt 4507 NM_198232 RNASE1 ccttgtccgggcgcaacatgcaattatattaaactcggccaaaccctctgcgggataaagg ggttttgtt 4508 NM_198400 NEDD4 ggatgattctgtgactcatagaacatgatgttaaatgagaccagactcaactgccaccagtc cccagctg 4509 NM_199335 FYB gaccccgaagatggtgcagcttggatagtgaatgtgcaagttagctatgcagagtgtactt ccttttctg 4510 NM_199423 WWP2 ctcactttgaaagtggtgtccgcaaagcccaaggtgcataatcgtcaacctcgaattaactc ctacgtgg 4511 NM_201592 GPM6A tagtaggtagggggtactactagggatatctgtggcatgattatgcattccgtagtattattta attaat 4512 NM_201632 TCF7 agcggcatgtacaaagagaccgtctactccgccttcaatctgctcatgcattacccacccc cctcgggag 4513 NM_201998 SF1 aaagttgccgagggtaggttcatctccaggtttcgggattcccatccgtcctggcgatcctg ccagcagt 4514 NM_212474 FN1 ttgttaccgtgggcaactctgtcaacgaaggcttgaaccaacctacggatgactcgtgcttt gaccccta 4515 R14777 CYFIP2 tcctttcacccaagaaccacaacgagacaaacctgccaacgtccagccttattacctctatg gatccaag 4516 R56397 PIK3C3 cgtaaacagtgttacacggctttcctccacctgcgaaggtattctaatctgattttgaacttgtt ttcct 4517 R59027 GRP58 ctcctccagcctcattgaaactctttttgtggatttgatgaccttatggatattgccaaagtttaa ggca 4518 R72151 GNL3 gcagactgctaaactgttctctgtataagttatggtatgcatgagctgtgtaaattttgtgaata tgtat 4519 R79128 MAP3K1 aagtcttactctgtatgtaacaatccatcattcaccttcactactggtagtaacatagagctgc catttt 4520 R86893 C6orf110 tgcacagttctcgaagcccgcccgtgttacaacgtggctcgcctaatgttcctcgatgcag agaggaaga 4521 T07281 NRIP1 gtgagaaagggcatacatccacagattcactttgtttatgcatatgtagatacaaggatgca catataca 4522 T28925 ITGAL tttccctgtttaatgattgacgtacttagcagctatctctcagtgaactgtgagggtaaaggct atactt 4523 U60115 FHL1 aatacatactaacattcttgtaggagtggttagagaagctgatgcctcatttctacattctgtc attagc 4524 U79271 AKT3 acattcatctggtttagacttaatatgccacaacgcaccacgaccttcccagggtgacacc gcctcagcc 4525 W04885 MYL4 cagtacatccccgcactgggcgtaggtgattttcatctctccagtcggggtccggtcaaac aatgaaaag 4526 X66087 MYBL1 acttagggatggctcattgaacgatggtggtaatatggcgctaaaacatacaccactgaaa acactacca 4527 AK024272 gtgatgttataaatgaggggagtaaaggaacatgagataaccactaatatgacataccaat agactatga 4528 AK025231 IGLC2 agcaacaggcggcgagtcaaaacccaaggtgtgtttatctaaactgggcaattcctcttcta ggaattta 4529 AL080190 taaagcgaggaagcagatgccaggcagtgaagacttgcacaccgtcacactgttaactg gtagagaggca 4530 BU618233 cgataaatccctttaatctcctctacatatactgagtattaaaaaacagaatcggctagaaca ttgttgc

The polynucleotide probes of an HCP combination can comprise RNA, DNA, RNA or DNA mimetics, or combinations thereof, and can be single-stranded or double-stranded. Thus the polynucleotide probes can be composed of naturally-occurring nucleobases, sugars and covalent internucleoside (backbone) linkages as well as polynucleotide probes having non-naturally-occurring portions which function similarly. Such modified or substituted polynucleotide probes may provide desirable properties such as, for example, enhanced affinity for a target gene and increased stability.

As is known in the art, a nucleoside is a base-sugar combination and a nucleotide is a nucleoside that further includes a phosphate group covalently linked to the sugar portion of the nucleoside. In forming oligonucleotides, the phosphate groups covalently link adjacent nucleosides to one another to form a linear polymeric compound, with the normal linkage or backbone of RNA and DNA being a 3′ to 5′ phosphodiester linkage. Specific examples of polynucleotide probes useful in this invention include oligonucleotides containing modified backbones or non-natural internucleoside linkages. As defined in this specification, oligonucleotides having modified backbones include both those that retain a phosphorus atom in the backbone and those that lack a phosphorus atom in the backbone. For the purposes of the present invention, and as sometimes referenced in the art, modified oligonucleotides that do not have a phosphorus atom in their internucleoside backbone can also be considered to be oligonucleotides.

Exemplary polynucleotide probes having modified oligonucleotide backbones include, for example, those with one or more modified internucleotide linkages that are phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters, aminoalkylphosphotriesters, methyl and other alkyl phosphonates including 3′-alkylene phosphonates and chiral phosphonates, phosphinates, phosphoramidates including 3′amino phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkyl-phosphonates, thionoalkylphosphotriesters, and boranophosphates having normal 3′-5′ linkages, 2′-5′ linked analogs of these, and those having inverted polarity wherein the adjacent pairs of nucleoside units are linked 3′-5′ to 5′-3′ or 2′-5′ to 5′-2′. Various salts, mixed salts and free acid forms are also included.

Exemplary modified oligonucleotide backbones that do not include a phosphorus atom are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatom and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages. Such backbones include morpholino linkages (formed in part from the sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulphone backbones; formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones; alkene containing backbones; sulphamate backbones; methyleneimino and methylenehydrazino backbones; sulphonate and sulfonamide backbones; amide backbones; and others having mixed N, O, S and CH₂ component parts.

The present invention also contemplates oligonucleotide mimetics in which both the sugar and the internucleoside linkage of the nucleotide units are replaced with novel groups. The base units are maintained for hybridization with an appropriate nucleic acid target compound. An example of such an oligonucleotide mimetic, which has been shown to have excellent hybridization properties, is a peptide nucleic acid (PNA) [Nielsen et al., Science, 254:1497-1500 (1991)]. In PNA compounds, the sugar-backbone of an oligonucleotide is replaced with an amide containing backbone, in particular an aminoethylglycine backbone. The nucleobases are retained and are bound directly or indirectly to aza-nitrogen atoms of the amide portion of the backbone.

The present invention also contemplates polynucleotide probes comprising “locked nucleic acids” (LNAs), which are novel conformationally restricted oligonucleotide analogues containing a methylene bridge that connects the 2′-O of ribose with the 4′-C (see, Singh et al., Chem. Commun., 1998, 4:455-456). LNA and LNA analogues display very high duplex thermal stabilities with complementary DNA and RNA, stability towards 3′-exonuclease degradation, and good solubility properties. Synthesis of the LNA analogues of adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil, their oligomerization, and nucleic acid recognition properties have been described (see Koshkin et al., Tetrahedron, 1998, 54:3607-3630). Studies of mismatched sequences show that LNA obey the Watson-Crick base pairing rules with generally improved selectivity compared to the corresponding unmodified reference strands.

LNAs form duplexes with complementary DNA or RNA or with complementary LNA, with high thermal affinities. The universality of LNA-mediated hybridization has been emphasized by the formation of exceedingly stable LNA:LNA duplexes (Koshkin et al., J. Am. Chem. Soc., 1998, 120:13252-13253). LNA:LNA hybridization was shown to be the most thermally stable nucleic acid type duplex system, and the RNA-mimicking character of LNA was established at the duplex level. Introduction of three LNA monomers (T or A) resulted in significantly increased melting points toward DNA complements.

Synthesis of 2′-amino-LNA (Singh et al., J. Org. Chem., 1998, 63, 10035-10039) and 2′-methylamino-LNA has been described and thermal stability of their duplexes with complementary RNA and DNA strands reported. Preparation of phosphorothioate-LNA and 2′-thio-LNA have also been described (Kumar et al., Bioorg. Med. Chem. Lett., 1998, 8:2219-2222).

Modified polynucleotide probes may also contain one or more substituted sugar moieties. For example, oligonucleotides may comprise sugars with one of the following substituents at the 2′ position: OH; F; O-, S-, or N-alkyl; O-, S-, or N-alkenyl; O-, S- or N-alkynyl; or O-alkyl-O-alkyl, wherein the alkyl, alkenyl and alkynyl may be substituted or unsubstituted C₁ to C₁₀ alkyl or C₂ to C₁₀ alkenyl and alkynyl. Examples of such groups are: O[(CH₂)_(n)O]_(m)CH₃, O(CH₂)_(n)OCH₃, O(CH₂)_(n)NH₂, O(CH₂)_(n)CH₃, O(CH₂)_(n)ONH₂, and O(CH₂)_(n)ON[(CH₂)_(n)CH₃)]₂, where n and m are from 1 to about 10. Alternatively, the oligonucleotides may comprise one of the following substituents at the 2′ position: C₁ to C₁₀ lower alkyl, substituted lower alkyl, alkaryl, aralkyl, O-alkaryl or O-aralkyl, SH, SCH₃, OCN, Cl, Br, CN, CF₃, OCF₃, SOCH₃, SO₂CH₃, ONO₂, NO₂, N₃, NH₂, heterocycloalkyl, heterocycloalkaryl, aminoalkylamino, polyalkylamino, substituted silyl, an RNA cleaving group, a reporter group, an intercalator, a group for improving the pharmacokinetic properties of an oligonucleotide, or a group for improving the pharmacodynamic properties of an oligonucleotide, and other substituents having similar properties. Specific examples include 2′-methoxyethoxy (2′-O—CH₂CH₂OCH₃, also known as 2′-O-(2-methoxyethyl) or 2′-MOE) [Martin et al., Helv. Chim. Acta, 78:486-504 (1995)], 2′-dimethylaminooxyethoxy (O(CH₂)₂ON(CH₃)₂ group, also known as 2′-DMAOE), 2′-methoxy (2′-O—CH₃), 2′-aminopropoxy (2′-OCH₂CH₂CH₂NH₂) and 2′-fluoro (2′-F).

Similar modifications may also be made at other positions on the polynucleotide probes, particularly the 3′ position of the sugar on the 3′ terminal nucleotide or in 2′-5′ linked oligonucleotides and the 5′ position of 5′ terminal nucleotide. Polynucleotide probes may also have sugar mimetics such as cyclobutyl moieties in place of the pentofuranosyl sugar.

Polynucleotide probes may also include modifications or substitutions to the nucleobase. As used herein, “unmodified” or “natural” nucleobases include the purine bases adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U). Modified nucleobases include other synthetic and natural nucleobases such as 5-methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5-uracil (pseudouracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl and other 8-substituted adenines and guanines, 5-halo particularly 5-bromo, 5-trifluoromethyl and other 5-substituted uracils and cytosines, 7-methylguanine and 7-methyladenine, 8-azaguanine and 8-azaadenine, 7-deazaguanine and 7-deazaadenine and 3-deazaguanine and 3-deazaadenine. Further nucleobases include those disclosed in U.S. Pat. No. 3,687,808; The Concise Encyclopedia Of Polymer Science And Engineering, (1990) pp 858-859, Kroschwitz, J. I., ed. John Wiley & Sons; Englisch et al., Angewandte Chemie, Int. Ed., 30:613 (1991); and Sanghvi, Y. S., (1993) Antisense Research and Applications, pp 289-302, Crooke, S. T. and Lebleu, B., ed., CRC Press. Certain of these nucleobases are particularly useful for increasing the binding affinity of the polynucleotide probes of the invention. These include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6 and O-6 substituted purines, including 2-aminopropyladenine, 5-propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to increase nucleic acid duplex stability by 0.6-1.2° C. [Sanghvi, Y. S., (1993) Antisense Research and Applications, pp 276-278, Crooke, S. T. and Lebleu, B., ed., CRC Press, Boca Raton].

One skilled in the art will recognise that it is not necessary for all positions in a given polynucleotide probe to be uniformly modified. The present invention, therefore, contemplates the incorporation of more than one of the aforementioned modifications into a single polynucleotide probe or even at a single nucleoside within the probe.

One skilled in the art will also appreciate that the nucleotide sequence of the entire length of the polynucleotide probe does not need to be derived from the target gene. Thus, the polynucleotide probe may comprise nucleotide sequences at the 5′ and/or 3′ termini that are not derived from the target gene. Nucleotide sequences which are not derived from the nucleotide sequence of the target gene may provide additional functionality to the polynucleotide probe. For example, they may provide a restriction enzyme recognition sequence or a “tag” that facilitates detection, isolation, purification or immobilisation onto a solid support. Alternatively, the additional nucleotides may provide a self-complementary sequence that allows the primer/probe to adopt a hairpin configuration. Such configurations are necessary for certain probes, for example, molecular beacon and Scorpion probes, which can be used in solution hybridization techniques.

The polynucleotide probes can incorporate moieties useful in detection, isolation, purification, or immobilisation, if desired. Such moieties are well-known in the art (see, for example, Ausubel et al., (1997 & updates) Current Protocols in Molecular Biology, Wiley & Sons, New York) and are chosen such that the ability of the probe to hybridize with its target sequence is not affected.

Examples of suitable moieties are detectable labels, such as radioisotopes, fluorophores, chemiluminophores, enzymes, colloidal particles, and fluorescent microparticles, as well as antigens, antibodies, haptens, avidin/streptavidin, biotin, haptens, enzyme cofactors/substrates, enzymes, and the like.

1.2.1 Preparation of Polynucleotide Probes

The polynucleotide probes of the present invention can be prepared by conventional techniques well-known to those skilled in the art. For example, the polynucleotide probes can be prepared using solid-phase synthesis using commercially available equipment, such as the equipment available from Applied Biosystems Canada Inc., Mississauga, Canada. As is well-known in the art, modified oligonucleotides, such as phosphorothioates and alkylated derivatives, can also be readily prepared by similar methods. The polynucleotide probes can also be synthesized directly on a solid support according to methods standard in the art. This method of synthesizing polynucleotides is particularly useful when the polynucleotide probes are part of a nucleic acid array.

Alternatively, the polynucleotide probes of the present invention can be prepared by enzymatic digestion of the naturally occurring target gene, or mRNA or cDNA derived therefrom, by methods known in the art.

1.2.2 Testing of Polynucleotide Probes

Each polynucleotide probe suitable for use in the HCP combination must be able to specifically detect the expression of a target gene in the HCP set. As noted previously, the specificity or uniqueness of the polynucleotide probe can be determined in silico using methods known in the art.

Alternatively, the ability of the polynucleotide probes to specifically detect the expression of the target gene or mRNA in a sample can be assessed by other standard methods (see, for example, Ausubel et al., (1997 & updates) Current Protocols in Molecular Biology, Wiley & Sons, New York), including hybridization techniques such as Southern or Northern blotting using appropriate controls, and may include one or more additional steps, such as reverse transcription, transcription, PCR, RT-PCR and the like. The testing of the specificity of the polynucleotide probes of the HCP combination using these methods is well within the abilities of a worker skilled in the art.

1.3 Hematological Cancer Profiling (HCP) Combination

An HCP combination comprises a plurality of polynucleotide probes designed to target genes of one or more HCP set, as described above. The HCP combination can be tailored by selection of polynucleotide probes that correspond to those HCP sets that represent a hematological cancer and/or a feature(s) of interest in a hematological cancer. Thus, for example, if one is interested in investigating various features of a single hematological cancer, for example, lymphoma, one would select an HCP combination that comprised probes to the HCP set representing the lymphoma of interest. Similarly, if one is interested in investigating features of several lymphomas, then a combination would be selected that comprised probes representing several HCP sets.

In one embodiment of the present invention, an HCP combination comprises a plurality of polynucleotide probes derived from the nucleotide sequences of the genes of one HCP set. In another embodiment, an HCP combination comprises a plurality of polynucleotide probes derived from the nucleotide sequences of the genes of two or more HCP sets. In another embodiment, the HCP combination comprises a plurality of polynucleotide probes derived from the nucleotide sequences of the genes of three or more HCP sets. In a further embodiment, the HCP combination comprises a plurality of polynucleotide probes derived from the nucleotide sequences of the genes of four or more HCP sets. In other embodiments, the HCP combination comprises a plurality of polynucleotide probes derived from the nucleotide sequences of five or more HCP sets, and six or more HCP sets.

Members of an HCP set may be targeted by one or more than one polynucleotide probe of the HCP combination. Therefore, the HCP combination can comprise several polynucleotide probes targeted to only one gene in an HCP set and other probes that each target a different gene. In one embodiment, polynucleotide probes within the HCP combination each target a different member of an HCP set. In another embodiment, one or more polynucleotide probes of the HCP combination target the same member of an HCP set.

Accordingly, the HCP combination comprises between one and about 10,000 polynucleotide probes. In one embodiment of the present invention, the HCP combination comprises at least 2 polynucleotide probes. In another embodiment, the HCP combination comprises at least 5 polynucleotide probes. In other embodiments, the HCP combination comprises at least 10, 20, 30, 40, 50, 100, 150, 200 and 300 polynucleotide probes. In one embodiment, the HCP combination comprises from about 10 to about 300 polynucleotide probes. In another embodiment, the HCP combination comprises from about 20 to about 300 polynucleotide probes. In a further embodiment, the HCP combination comprises from about 30 to about 300 polynucleotide probes. In other embodiments, the HCP combination comprises from about 40 to about 300, from about 50 to about 300, from about 75 to about 300, and from about 100 to about 300 polynucleotide probes.

In an alternate embodiment, the HCP combination comprises from about 100 to about 10,000 polynucleotide probes. In a further embodiment, the HCP combination comprises from about 200 to about 5,000 polynucleotide probes. In another embodiment, the HCP combination comprises from about 200 to about 4,000 polynucleotide probes. In yet another embodiment, the HCP combination comprises from about 200 to about 3,000 polynucleotide probes. In other embodiments, the HCP combination comprises from about 200 to about 2,000, from about 300 to about 2,000, from about 400 to about 2,000, from about 500 to about 2,000, from about 500 to about 1,500, from about 750 to about 1,500, from about 750 to about 1250, and from about 800 to about 1,200 polynucleotide probes.

In a further embodiment, the HCP combination comprises from about 1,000 to about 10,000 polynucleotide probes. For example, the HCP combination can comprise from about 2,000 to about 10,000 polynucleotide probes. In one embodiment, the HCP combination comprises from about 2,500 to about 9,000 polynucleotide probes. In yet another embodiment, the HCP combination comprises from about 3,000 to about 8,000 polynucleotide probes. In other embodiments, the HCP combination comprises from about 3,000 to about 7,000, from about 3,000 to about 6,000, from about 3,500 to 6,000, from about 4,000 to about 6,000, and from about 4,000 to about 5,000 polynucleotide probes.

As indicated above, an HCP combination comprises a plurality of polynucleotide probes designed to target genes of one or more HCP set. Representative, non-limiting examples of candidate genes for inclusion in HCP sets are shown in Table 1, above. Accordingly, in one embodiment of the present invention, the HCP combination comprises between ten and 5,000 polynucleotide probes, wherein each of the probes comprise a sequence corresponding to or complementary to, the sequence of one of the genes listed in Table 1. Representative, non-limiting examples of HCP sets are provided in Tables 2-19. Thus, in another embodiment, the HCP combination comprises between ten and 5,000 polynucleotide probes, wherein each of the probes comprises a sequence corresponding to or complementary to a gene of an HCP set selected from the group of:

-   -   (a) an HCP set comprising one or more genes as set forth in         Table 2;     -   (b) an HCP set comprising one or more genes as set forth in         Table 3;     -   (c) an HCP set comprising one or more genes as set forth in         Table 4;     -   (d) an HCP set comprising one or more genes as set forth in         Table 5;     -   (e) an HCP set comprising one or more genes as set forth in         Table 6;     -   (f) an HCP set comprising one or more genes as set forth in         Table 7;     -   (g) an HCP set comprising one or more genes as set forth in         Table 8;     -   (h) an HCP set comprising one or more genes as set forth in         Table 9;     -   (i) an HCP set comprising one or more genes as set forth in         Table 10;     -   (j) an HCP set comprising one or more genes as set forth in         Table 11;     -   (k) an HCP set comprising one or more genes as set forth in         Table 12;     -   (l) an HCP set comprising one or more genes as set forth in         Table 13;     -   (m) an HCP set comprising one or more genes as set forth in         Table 14;     -   (n) an HCP set comprising one or more genes as set forth in         Table 15;     -   (o) an HCP set comprising one or more genes as set forth in         Table 16;     -   (p) an HCP set comprising one or more genes as set forth in         Table 17;     -   (q) an HCP set comprising one or more genes as set forth in         Table 18;     -   (r) an HCP set comprising one or more genes as set forth in         Table 19; and     -   (s) an HCP set comprising one or more genes selected from the         genes set forth in Tables 2-19.

In a further embodiment, the HCP combination comprises between ten and 5,000 polynucleotide probes, wherein each of the probes comprises a sequence corresponding to or complementary to a gene of an HCP set selected from the group of:

-   -   (a) an HCP set as set forth in Table 2;     -   (b) an HCP set as set forth in Table 3;     -   (c) an HCP set as set forth in Table 4;     -   (d) an HCP set as set forth in Table 5;     -   (e) an HCP set as set forth in Table 6;     -   (f) an HCP set as set forth in Table 7;     -   (g) an HCP set as set forth in Table 8;     -   (h) an HCP set as set forth in Table 9;     -   (i) an HCP set as set forth in Table 10;     -   (j) an HCP set as set forth in Table 11;     -   (k) an HCP set as set forth in Table 12;     -   (l) an HCP set as set forth in Table 13;     -   (m) an HCP set as set forth in Table 14;     -   (n) an HCP set as set forth in Table 15;     -   (o) an HCP set as set forth in Table 16;     -   (p) an HCP set as set forth in Table 17;     -   (q) an HCP set as set forth in Table 18; and     -   (r) an HCP set as set forth in Table 19.

In another embodiment, the HCP combination represents more than one HCP set and comprises between about 10 and about 5,000 probes, each of said probes comprising a sequence corresponding to, or complementary to, a gene listed in any one of Tables 2-19.

In a further embodiment, the HCP combination comprises between ten and 5,000 polynucleotide probes, each of the probes having a sequence corresponding to or complementary to a nucleotide sequence selected from any one of Tables 20-23, wherein the HCP combination represents one or more HCP sets selected from the group of:

-   -   (a) an HCP set as set forth in Table 2;     -   (b) an HCP set as set forth in Table 3;     -   (c) an HCP set as set forth in Table 4;     -   (d) an HCP set as set forth in Table 5;     -   (e) an HCP set as set forth in Table 6;     -   (f) an HCP set as set forth in Table 7;     -   (g) an HCP set as set forth in Table 8;     -   (h) an HCP set as set forth in Table 9;     -   (i) an HCP set as set forth in Table 10;     -   (j) an HCP set as set forth in Table 11;     -   (k) an HCP set as set forth in Table 12;     -   (l) an HCP set as set forth in Table 13;     -   (m) an HCP set as set forth in Table 14;     -   (n) an HCP set as set forth in Table 15;     -   (o) an HCP set as set forth in Table 16;     -   (p) an HCP set as set forth in Table 17;     -   (q) an HCP set as set forth in Table 18; and     -   (r) an HCP set as set forth in Table 19.

Representative, non-limiting examples of suitable probe sequences targeted to the genes of the HCP sets in Tables 2-19 are provided in Tables 20-23. Accordingly, in a specific embodiment of the present invention, the HCP combination comprises at least ten polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences set forth in SEQ ID NOs:1-4530 (Tables 20-23). In another embodiment, the HCP combination comprises at least 20 polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences set forth in SEQ ID NOs:1-4530 (Tables 20-23). In another embodiment, the HCP combination comprises at least 30 polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences as set forth in SEQ ID NOs:1-4530 (Tables 20-23). In a further embodiment, the HCP combination comprises at least 40 polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences as set forth in SEQ ID NOs:1-4530 (Tables 20-23). In other embodiments, the HCP combination comprises at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90 and at least 100 polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences as set forth in SEQ ID NOs:1-4530 (Tables 20-23). In further embodiments, the HCP combination comprises at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90 and at least 100 polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences as set forth in SEQ ID NOs:1-1153 (Table 20). In other embodiments, the HCP combination comprises at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90 and at least 100 polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences as set forth in SEQ ID NOs:1154-2299 (Table 21). In further embodiments, the HCP combination comprises at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90 and at least 100 polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences as set forth in SEQ ID NOs:2300-3426 (Table 22). In further embodiments, the HCP combination comprises at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90 and at least 100 polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences as set forth in SEQ ID NOs:3427-4530 (Table 23).

1.3.1 Testing of the HCP Combination

The HCP combination can be tested for its ability to detect the expression pattern of genes in the one or more HCP sets that it represents using methods well known in the art and one or more appropriate biological samples that represent the hematological cancer and features that are to be investigated with the HCP combination. Suitable biological samples include blood or tissue samples from patients with the hematological cancer, where each sample is known to exhibit one or more feature of a particular hematological cancer. Alternatively, or in addition, biological samples can be obtained from cultures of appropriate hematological cancer cell lines, where each cell line is known to exhibit one or more feature of a particular hematological cancer. Exemplary hematological cancer cell lines that can be used for testing the HCP combination are provided in Table 24, below. One skilled in the art will appreciate that other hematological cancer cell lines are available that are also suitable for testing an HCP combination. Selection of appropriate cell lines for the testing of a particular HCP combination is within the ordinary skills of a worker in the art. If necessary one or more control samples can be used for comparison purposes, for example, a biological sample taken from a healthy subject, or a normal cell line.

The ability of the HCP combination to detect expression patterns in one or more biological samples can be determined using methods known in the art for the analysis of gene expression (see, for example, Ausubel et al., (1997 & updates) Current Protocols in Molecular Biology, Wiley & Sons, New York). Such methods are typically hybridization-based methods, such as Northern blotting. For example, RNA can be prepared from blood or tissue samples from patients or cultures of cell lines, as noted above, and separated on a gel. Probes of the HCP combination can be labelled and used to detect the expression of specific mRNAs from the sample on the gel, according to methods well known in the art. Other testing methods can include additional steps, such as reverse transcription, RT-PCR and/or PCR (including multiplex PCR). Array based methods can also be used to test an HCP combination. The expression pattern detected with the probes of the HCP combination should correspond to the expression pattern expected for each sample.

TABLE 24 Cell lines exhibiting a gene expression pattern representative of a type of lymphoma or a type of leukemia Representative Type of Lymphoma cell line anaplastic large-cell lymphoma Karpas 299 anaplastic large-cell lymphoma Ki-JK anaplastic large-cell lymphoma SR 786 anaplastic large-cell lymphoma SUDHL-1 anaplastic large cell lymphoma DEL body-cavity lymphoma BC-1 body-cavity lymphoma BC-2 body-cavity lymphoma BC-3 body-cavity lymphoma BCBL1 Burkitt lymphoma BL60 Burkitt lymphoma CA46 Burkitt lymphoma Namalwa Burkitt lymphoma Raji Burkitt Lymphoma Ramos Burkitt lymphoma Thomas diffuse large B-cell lymphoma HBL-2 diffuse large B-cell lymphoma KIS-1 Follicular Lymphoma FL-18 Follicular Lymphoma FL-618 Hodgkin's Disease - H/RS derived cell KMH2 lines Hodgkin's lymphoma DEV Hodgkin's lymphoma HDLM-2 Hodgkin's lymphoma L428 Hodgkin's lymphoma L540 immunoblastic lymphoma line DOHH-2 lymphoblastoid cell lines GM 03299 lymphoblastoid cell lines GM 11854 mantle-cell lymphoma Granta 519 mantle-cell lymphoma NCEB Peripheral T-cell lymphoma H9 Peripheral T-cell lymphoma yt (cytotoxic T-cell lymphoma T-lymphoblastic leukemia/lymphoma CEM T-lymphoblastic leukemia/lymphoma HSB T-lymphoblastic leukemia/lymphoma Jurkat T-lymphoblastic leukemia/lymphoma Molt-4 transformed follicular lymphoma SUDHL-10 transformed follicular lymphoma SUDHL-4 transformed follicular lymphoma SUDHL-5 transformed follicular lymphoma SUDHL-6 Chronic lymphocytic leukemia MEC-1 Acute myelogenous leukemia K-562

2. Hematological Cancer Profiling (HCP) Arrays

The present invention contemplates that the HCP combinations may be provided as an array (HCP array). In the context of the present invention, an “array” is a spatially or logically organized collection of polynucleotide probes. Typically the polynucleotide probes are attached to a solid substrate and are ordered so that the location (on the substrate) and the identity of each are known. The polynucleotide probes can be attached to one of a variety of solid substrates capable of withstanding the reagents and conditions necessary for use of the array. Examples include, but are not limited to, polymers, such as (poly)tetrafluoroethylene, (poly)vinylidenedifluoride, polystyrene, polycarbonate, polypropylene and polystyrene; ceramic; silicon; silicon dioxide; modified silicon; (fused) silica, quartz or glass; functionalized glass; paper, such as filter paper; diazotized cellulose; nitrocellulose filter; nylon membrane; and polyacrylamide gel pad. Substrates that are transparent to light are useful for arrays that will be used in an assay that involves optical detection.

Examples of array formats include membrane or filter arrays (for example, nitrocellulose, nylon arrays), plate arrays (for example, multiwell, such as a 24-, 96-, 256-, 384-, 864- or 1536-well, microtitre plate arrays), pin arrays, and bead arrays (for example, in a liquid “slurry”). Arrays on substrates such as glass or ceramic slides are often referred to as chip arrays or “chips.” Such arrays are well known in the art. In one embodiment of the present invention, the HCP array is a chip.

The HCP array can comprise a single representation of each polynucleotide probe, for example, in the form of a spot deposited on a solid surface, or the array can comprise multiple representations of the same polynucleotide probe. Currently available methods of creating chip arrays, for example, allow for the incorporation of up to about 40,000 spots on a single chip.

The HCP arrays of the present invention, therefore, can comprise as few as two spots or as many as 40,000 spots. Typically an array will comprise between about 15 and about 40,000 spots. The actual number of spots included on the array will be dependent on the number of probes in the HCP combination being used to create the array, how many times each probe is represented in the array, the number of control probes, if any, being included in the array, and the format of the array.

As is known in the art probes of varying lengths can be incorporated into the HCP arrays. In one embodiment of the invention, the probes incorporated into the array are between about 20 and about 100 nucleotides in length. In another embodiment of the present invention, the probes incorporated into the array are between about 25 and about 40 nucleotides in length. In another embodiment, the probes are between about 28 and about 32 nucleotides in length. In a further embodiment, the probes incorporated into the array are 30-mers. In alternate embodiments, the probes incorporated into the array are between about 40 and about 55 nucleotides in length, or are between about 48 and about 52 nucleotides in length. In a further embodiment, the probes incorporated into the array are 50-mers. In further embodiments, the probes incorporated into the array are between about 55 and about 65 nucleotides in length, or are between about 58 and about 62 nucleotides in length. In yet another embodiment, the probes incorporated into the array are 60-mers. In other embodiments, the probes incorporated into the array are between about 65 and about 75 nucleotides in length, or are between about 68 and about 72 nucleotides in length. In a further embodiment, the probes incorporated into the array are 70-mers.

HCP arrays can be designed in various formats, for example, in “small” or “large” format. Small arrays comprise polynucleotide probes that are generally representative of less than 500 genes. In one embodiment, the small arrays contemplated by the present invention comprise polynucleotide probes representative of between about 15 and about 499 genes. In another embodiment, a small array comprises polynucleotide probes representative of between about 50 and about 400 genes. In a further embodiment, a small array comprises polynucleotide probes representative of between about 100 and about 350 genes. In yet another embodiment, a small array comprises polynucleotide probes representative of between about 200 and about 300 genes. As indicated above, the probes representing each gene in a small array can be spotted singly or in multiplicate.

Alternatively, HCP arrays can be designed in a “large” format. Large arrays comprise polynucleotide probes that are generally representative of 500 or more genes. In one embodiment, the large arrays contemplated by the present invention comprise polynucleotide probes representative of between about 500 and about 6000 genes. In another embodiment, a large array comprises polynucleotide probes representative of between about 600 and about 4000 genes. In a further embodiment, a large array comprises comprise polynucleotide probes representative of between about 700 and about 2000 genes. In yet another embodiment, a large array comprises polynucleotide probes representative of between about 900 and about 1000 genes. In still another embodiment, the large array comprises polynucleotide probes representative of between about 1000 and about 1300 genes As for the small arrays, the probes representing each gene in a large array can be spotted singly or in multiplicate.

One skilled in the art will appreciate that as the technology for creating arrays advances, it may be possible to include larger numbers of probes in a single array. Arrays created using such technology with the HCP combinations of the present invention are considered to be within the scope of the invention.

Representative non-limiting examples of combinations of probes that can be used in the preparation of an HCP array include combinations that comprise at least 10 of the polynucleotide probes as set forth in any one of Tables, 20, 21, 22, 23, 25, 26, 27, and 28. In one embodiment of the invention, the HCP array comprises at least ten polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences as set forth in Table 20, 21, 22, 23, 25, 26, 27, and 28. In other embodiments, the HCP array comprises at least 20, at least 30, at least 40, at least 50, at least 60, at least 70, at least 80, at least 90 and at least 100 polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences as set forth in Table 20, 21, 22, 23, 25, 26, 27, and 28.

In another embodiment, the HCP array comprises at least 100 polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences as set forth in Table 20, 21, 22, 23, 25, 26, 27, and 28. In other embodiments, the HCP array comprises at least 200, at least 300, at least 400, at least 500, at least 600, at least 700, at least 800 and at least 900 polynucleotide probes, wherein each of the probes comprises at least 15 consecutive nucleotides of one of the sequences as set forth in Table 20, 21, 22, 23, 25, 26, 27, and 28.

In another embodiment, an HCP array comprises a combination of probes as set forth in any one of Tables 20, 21, 22, 23, 25, 26, 27, and 28.

TABLE 25 Polynucleotide probe sequences for preparation of a small 50 mer nucleic acid array GenBank Accession Number of Target gene Oligonucleotide sequence (5′ to 3′) NM_001728 TCGTGAGTTCCTCGCAGGGCCGGTCAGAGCTACACATTGAGAACCTGAAC NM_018462 GCTCGGGTGACAAAAGGTGAGACACTCACTAGAACAGTGCCGTGCTGCTG NM_002266 CCAGAAACTACCTCTGAAGGCTACACTTTCCAAGTTCAGGATGGGGCTCC NM_004310 GGCGACTCTGCTGTGGGGAAAACCTCTCTGTTGGTGCGCTTCACCTCCGA NM_006152 AGGACTCATGGACGTCTCTAGAACATATCTTGTGGCCATTTACCAGACTC NM_012203 CATCAGCAGGGGCGACGTCGTAAACCAGGACGACCTGTACCAGGCCTTGG NM_058197 ATTGGAATCAGGTAGCGCTTCGATTCTCCGGAAAAAGGGGAGGCTTCCTG NM_000277 CGCTACGACCCATACACCCAAAGGATTGAGGTCTTGGACAATACCCAGCA NM_133480 GCTAATTGCCCAGGGCCTTTTGGAGTCTGAGGACCGCCCCGCAGAGGACT NM_002447 AACAGCCGCAGTTCTCACCCATGCCAGGGAATGTACGCCGGCCCCGGCCA NM_001197 GGAGAACATAATGAGGTTCTGGAGATCCCCGAACCCCGGGTCCTGGGTGT NM_030674 GCCTGCTCATCGAGTAATGGTGAAGGCCACTGAAACCCGCCGAGAAAAAG NM_004907 GGGACGTTGGACTGGTCCCGAGCAAGAAAGCCCGTCTGGAAGAAAAGGAA NM_002910 TTTCAAAGGCTGCTTCCACGTGCCGCGGTGCCTAGCCATGTGCGAGGAGA NM_001901 TGGGCCTGCCCTCGCGGCTTACCGACTGGAAGACACGTTTGGCCCAGACC NM_005526 TAGAGGAGGCGAGTCCCGGGCGCCCATCTTCCGTGGACACCCTCTTGTCC NM_000852 CCTCCCCTGAGTACGTGAACCTCCCCATCAATGGCAACGGGAAACAGTGA NM_002511 GGGAGGAAGTCCTATCAAGAGAGAGGAACCAGCTACCTACTCAGCTCTTC NM_000365 TCCTTGTGGGTGGTGCTTCCCTCAAGCCCGAATTCGTGGACATCATCAAT NM_001891 CCAAGAACTTCTACTTAACCCCACCCACCAGATCTACCCTGTGACTCAGC NM_006851 TACGGACCAGGAGGGAATTACCCAACTTGGCCATATAAGAGAGGAGCCAC NM_005178 GAGTGCCAAGAAACCGTGCAGCTCTTGCTAGAGCGCGGTGCCGACATCGA NM_005582 GCAAACCCGCCATCTCTAAGGGGAGTTAAGCTATCTGATGTCAAGCTTTC NM_001344 TGGGGAGTTTCATCCTAGCGGTTTGCCTGAGAATACAGATCAACCCACAG NM_002086 TTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGT NM_002228 TCCTCCCGTCCGAGAGCGGACCTTATGGCTACAGTAACCCCAAGATCCTG NM_002961 GTAACGAATTCTTTGAAGGCTTCCCAGATAAGCAGCCCAGGAAGAAATGA NM_002987 GGGGCTTCTCTGCAGCACATCCACGCAGCTCGAGGGACCAATGTGGGCCG NM_182908 ACGTCAACGGGGAGAACATTGCGGTGGCAGGCTACTCCACTCGGCTCTGA NM_004434 TACCCCTGCTCGCAGTTCAGGGCTCCAAGCCACATCTACGGCGGGCACAG NM_002444 CATGCTGAGAACATGCGACTGGGCCGAGACAAATACAAGACCCTGCGCCA NM_002048 TACGATGAGGACTACGATGACGAGCAGCGCACCGGGGGCGCGGGTGGTGA BM_722299 CCTGCTCTCGCACCGTCCGAGCGGAGCTTTCGTTTTCAGTGAGCCAGGTG NM_004289 GCCAGTCAATCCCAACCACTATGCTCTCCAGTGTACCCATGATGGAAGTA NM_004665 AGGTGCTGAAAGATGGGCGTTTGGTAAACAAGAATGGATCATCTGGGCCT NM_001715 TCCTCCTGATGGAAGTTGTCACTTATGGGCGGGTGCCATACCCAGGGATG NM_001783 AACGAGTCATACCAGCAGTCCTGCGGCACCTACCTCCGCGTGCGCCAGCC NM_001618 GGTGTAGACGTTCCTCTTGGGACCGGGATTTCATCTGGTGTGATAGACAC NM_002167 CAGACAGCCGAGCTCGCTCCGGAACTTGTCATCTCCAACGACAAAAGGAG NM_006115 CCAGCTTACAACCTTAAGCTTCTACGGGAATTCCATCTCCATATCTGCCT NM_015055 AGCCCTCCACCACACAAAGAAGCCCGCCAGCGTCGGAAAGAACTCCGGAA NM_000038 CAGGGCCAGTGCAGCACTCCACAACATCATTCACTCACAGCCTGATGACA NM_020992 AAGTGTTAAAGCTCCTGTCACTAAAGTGGCTGCGTCGATTGGAAATGCTC NM_002661 AGAAGATATGTTCAGCGATCCCAACTTTCTTGCTCATGCCACTTACCCCA NM_002838 CACACCACAGCTCTGCTGCCTTACCTGCACGCACCTCCAACACCACCATC NM_005215 CCAACAGAGGATTCAGCCAATGTGTATGAACAGGATGATCTGAGTGAACA NM_022743 TGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGC NM_004119 AGATGGATTTGGGGCTACTCTCTCCGCAGGCTCAGGTCGAAGATTCGTAG NM_024408 CAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTATCATCCTTTCCC NM_000314 GGAAGTCTATGTGATCAAGAAATCGATAGCATTTGCAGTATAGAGCGTGC NM_001795 ACGTGGATTACGACTTCCTTAACGACTGGGGACCCAGGTTTAAGATGCTG NM_001226 GAGACAATCTTACCCGCAGGTTTTCAGATCTAGGATTTGAAGTGAAATGC NM_006763 TTGGGGAGGACGGCTCCATCTGCGTCTTGTACGAGGAGGCCCCACTGGCC NM_053056 AACAAACAGATCATCCGCAAACACGCGCAGACCTTCGTTGCCCTCTGTGC NM_004126 GGGAATTCCAGAAGACAAGAACCCCTTTAAAGAAAAAGGCAGCTGTGTTA NM_006579 GGGCCACCCTCTCTACTTCTGGTTTTACTTTGTCTTCATGAATGCCCTGT NM_007360 TGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCAGCCTTCTGAAAGTAT NM_030956 TGCTAGGTCAATGCACACAAACATGGCACAGGGTTAGGAAAACAACCCAA NM_003254 GGGTTCCAAGCCTTAGGGGATGCCGCTGACATCCGGTTCGTCTACACCCC NM_001760 ACCCGCCATCCATGATCGCCACGGGCAGCATTGGGGCTGCAGTGCAAGGC NM_005225 TTTCAGATCTCCCTTAAGAGCAAACAAGGCCCGATCGATGTTTTCCTGTG NM_003810 TAGACATGGACCATGAAGCCAGTTTTTTCGGGGCCTTTTTAGTTGGCTAA NM_006325 GCACAGTATGAGCACGACTTAGAGGTTGCTCAGACAACTGCTCTCCCGGA NM_004225 GAAGATCAAAGACAACCCACTGATCCAGCCCCCCTACGAGGTCTGCATGA NM_005781 AGCTCTTCGGGCTGGGTCTGCGGCCCAGAGGGGAGTGCCACAAAGTGCTG NM_002648 CTGTATGATATGGTGTGTGGAGATATTCCTTTCGAGCATGACGAAGAGAT NM_006769 GAATCGCCTGGTCCCGGGAGATCGGTTTCACTACATCAATGGCAGTTTAT NM_004689 GCTGGCCGGGCCTGCGAGAGCTGTTACACCACACAGTCTTACCAGTGGTA NM_003403 CCCTCATAAAGGCTGCACAAAGATGTTCAGGGATAACTCGGCCATGAGAA NM_002592 AACGGTGACACTCAGTATGTCTGCAGATGTACCCCTTGTTGTAGAGTATA NM_005104 TCCTCTGCACAGCAAGTAGCAGTGTCACGCCTTAGCGCTTCCAGCTCCAG NM_004762 ATCAGCAGGGACCCTTTCTACGAAATGCTCGCAGCACGGAAAAAGAAGGT NM_004475 CTGTGCATGCCCTCACAGGCGTGGACCTGTCTAAGATACCCCTGATCAAG NM_134269 TCTACCGCTGTCTGGTCCAGAAGGGGCTGGTAAAAACCAAAAAGTCCTAA NM_017935 CAAGACAGAGCTCGGATAGAGAGTCCAGCCTTTTCTACTCTCAGGGGCTG NM_002129 GCTATGACAGGGAGATGAAAAATTACGTTCCTCCCAAAGGTGATAAGAAG MM_001469 AAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCA MM_006819 GCTACCAGCGCTGTATGATGGCGCAGTACAACCGGCACGACAGCCCCGAA NM_004941 ATGAGGAACCCAATGCCTGGAGAATATCTCGAGCTTTCCGACGGCGCTGA NM_003352 CTCTTTGAGGGTCAGAGAATTGCTGATAATCATACTCCAAAAGAACTGGG NM_000626 GCTTCACGGTGAAAATGCACTGCTACATGAACAGCGCCTCCGGCAATGTG NM_001237 CTACCTCAAAGCACCACAGCATGCACAACAGTCAATAAGAGAAAAGTACA BC011857 TCCTGAGCCTCTTCTACAGTACCACCGTCACCTTGTTCAAGGTGAAATGA NM_002466 TACTCCATGGACAACACTCCCCACACGCCAACCCCGTTCAAGAACGCCCT NM_000424 CCAGTCAAGTGTGTCCTTCCGGAGCGGGGGCAGTCGTAGCTTCAGCACCG AB037771 GCCAACCAGAACTAGACTCTATTTCTACCTGTCCAAATGAGACAGTTTCA NM_025113 AGCCCATTTTCAATTTGCTGAGCATCGGCCAAAGCCTGTATGCGAAAGCC NM_032873 ACCAATCCTTCCTCTTACCCATGGACCAACTGGGGGCTTCAACTGGAGAG NM_023037 TCCTCACTACTTTTCTTCCAGACTCCAGTGTTTCTGGCACTAGTCTCTGA NM_033306 TTGACCATCTGCCTCCGAGGAATGGAGCTGACTTTGACATCACAGGGATG NM_003217 CGTCCTTGTTGATACTCAACTCATTATTGAAAAGGCCGAACATGGAGATC AF509494 AAGAAGAAAGGCGACAGCAACTTCGTAGGAAGGTAGTTGAAATTCTTCCA NM_001781 CACATTCTCAATGCCATCAGACAGCCATGTTTCTTCATGCTCTGAGGACT NM_002984 CAGCCAGCTGTGGTATTCCAAACCAAAAGAAGCAAGCAAGTCTGTGCTGA BC025340 CGCAGCATGGAGTCTGCTCTCAGCTGTTGGGGAATTACCGATGCCTTTGA NM_030926 CCCCTCGCAACTTCTGGGAGCTCCTCATGAACGTGAAGAGGGGGACCTAC AF331856 GGTATTTGGTTTCCCAGTCCACTATACTGACGTCTCCAACATGAGCCGCT NM_000405 GAAAAAGCCATCCCAGCTCAGTAGCTTTTCCTGGGATAACTGTGATGAAG NM_000483 CCGCTGTAGATGAGAAACTCAGGGACTTGTACAGCAAAAGCACAGCAGCC NM_001888 CAGCCCACTGTGAGAAGACCACGGTGTTCAAGTCTTTGGGAATGGCAGTG NM_014670 GTCTGAGCTGACTCTGTTACTGAAGATTCAGGAGTATTGCTATGACAACA NM_003804 AGCTATCTTTGATAATACCACTAGTCTGACGGATAAACACCTGGACCCAA AB018263 TCAGGACCACCCTGCTGCTTAACTCCACGCTCACTGCCTCGGAGGTCTGA NM_006475 GCAGTCTTCAGCCTATTATCAAAACTGAAGGACCCACACTAACAAAAGTC NM_001786 AATCCTACAGGGGATTGTGTTTTGTCACTCTAGAAGAGTTCTTCACAGAG NM_031942 CGGCAGCGAGATGGACGGTGTGCGACTGGGGTCCTTGTGTATTTAGCCAA NM_001640 CGCATGGAGAACATTCGATTCTGCCGCCAATACCTGGTGTTCCATGACGG NM_002483 GTGCTCCTGTCCTCTCAGCTGTGGCCACCGTCGGCATCACGATTGGAGTG NM_003915 CACACCCATCCAGGTGCAATGCTCCGATTATGACAGTGACGGGTCACATG NM_147180 CCACAATGGGAAACGAGGCCAGTTACCCGGCGGAGATGTGCTCCCACTTT NM_000485 TATTCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGCGCC NM_004924 AACCCCTACACCACCGTCACCCCGCAAATCATCAACTCCAAGTGGGAGAA NM_003480 CTGCCCCCTAGGAGACTCCGTCGCTCCAATTACTTCCGACTTCCTCCCTG NM_002023 CAACAATGTCTACACCGTCCCCGATAGCTACTTCCGGGGGGCGCCCAAGC NM_006216 GCCGCTGAAAGTTCTTGGCATTACTGACATGTTTGATTCATCAAAGGCAA NM_003651 GCAGGTGAAGCACCAACTGAGAACCCTGCTCCACCCACCCAGCAGAGCAG NM_006565 GAGAGGACGACCCCCTGGCAGAACCAACCAGCCCAAACAGAACCAGCCAA NM_030666 CTTTTCTTTATTCGGCATAATTCCTCAGGTAGCATCCTATTCTTGGGGAG NM_005537 GGGGTGGAGGGTGGACGAGTTGATTTGAACGTCTTCGGGTCGCTCGGCCT NM_004235 CGTGGCCCCGGAAAAGGACCGCCACCCACACTTGTGATTACGCGGGCTGC NM_016269 CTATCAACCAGATTCTTGGCAGAAGGTGGCATGCCCTCTCCCGTGAAGAG NM_006164 TCAGCACCTTATATCTCGAAGTTTTCAGCATGCTACGTGATGAAGATGGA NM_004630 TCCTCACCCAACTCCCTTTGCCTCTCCCCAAACCGGGCCGCCAGGATCCC NM_003222 CGAACATACAGAACTGCTTGTCTCATTTCAGCCTGATTACCCACGGGTTT NM_000700 GCCATAAGGCATTGATCAGGATTATGGTTTCCCGTTCTGAAATTGACATG NM_019846 GGGCACATCAGGGGAAACACGAAACATACGGCCATAAAACTCCTTATTAG NM_006889 CCTGAAAGATCTGATGAAGCCCAGCGTGTTTTTAAAAGTTCGAAGACATC NM_032738 CAGAAACAGCATCTGTTGTGGCTATCACAGTCCAAGAACTGTTTCCAGCG NM_000417 TTATTATCAGTGCGTCCAGGGATACAGGGCTCTACACAGAGGTCCTGCTG BC019046 TCACCATCTTCATCACACTCTTCCTGTTAAGCGTGTGCTACAGTGCCACC NM_002189 GAGCGCTGTGTCTCTCCTGGCATGCTACCTCAAGTCAAGGCAAACTCCCC NM_004827 AGGGCATCGATCTCTCACCCTGGGGCTTGTGGAAGAATCACGTGGCCTTG NM_001647 ATCAAATCGAAGGTGAAGCCACCCCAGTTAACCTCACAGAGCCTGCCAAG NM_014257 AGACCAGTCCAAGCAGCAGCAAATCTATCAAGAACTGACCGATTTGAAGA NM_001830 TTGCCCAGAGGAGGGAACTGATTCTCGCAATAAATAACGCCAGACAGAGG NM_020944 CAAACAGGGCACAGGACTAAGGACAGGGCCTATGTTTGGACCAAAGGAAG NM_021643 CATCCTTGGTTTTCTACAGATTTTAGCGTCTCGAATTCAGCATATGGTGC NM_017784 AGGAACGGAAGCGCGAGAACCTCCGCACACCATGGAAGCCCAAATATTTT NM_022366 GCGTTCCAAAGATTGTGCTTATAAATGGCTGTATGATGAAACCCTGGAAG NM_002933 TGTGGCCTGTGAAGGGAGCCCATATGTGCCAGTCCACTTTGATGCTTCTG NM_022829 CCTTCCCGGACTGGGCTGATATGTACTCGGTCAATGTCACAGCATTGCCA NM_003339 AGATGATCCTTTAGTGCCTGAGATTGCTCGGATCTACAAAACAGATAGAG NM_005277 AATCTCTGCTTGGACCTTCGTCAGTTTGGAATTGTGACAATTGGAGAGGA NM_006820 CAAAGCCGGGTCATGAATGTCCATAAAATGCTAGGCATTCCTATTTCCAA NM_024728 CCCATGGCCCCTTCCTTCATCTTCAAGGATCAGCAAGGGTATTACACAAT NM_025263 GCTTTCACAAGGAACAGAGAAACCCTCGAAGGCTCAAAAGCTGGTCTCTT BC046632 AGCAGTGCCGGTGCATGTCCGTGAACCTGAGCGACTCGGACAAGCAGTGA NM_000877 TGGTCAGGGGACTTTACACAGGGACCACAGTCTGCAAAGACAAGGTTCTG NM_014365 TTGACAGCCTCTTGGCCCGACTGGGCTCTGCCTCGTCTCTCCTCCGCCTG AK092000 ATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAG NM_022436 GCTCAAATGTTTCTGTGACAACTAATCCAATGTGTGCCTTCACTCAAGGA NM_001165 CAACATTTGACTTGTGTAATTCCAATCCTGGATAGTCTACTAACTGCCGG BX647445 ACTGTTGCCCTGGCTGTATTCATAAGATTCCAGCTCCTTCAGGTGTTTGA BC022095 CATGCGCACGGGGTTCCTAGCTCCCACGTCTATGTTCACATTTGTGGTCC NM_031305 CAGACTGTCCACCTATGATAATGTCCATCAACAGTTCTCCATGATGAACC NM_006191 CCAATGGCCCCATGCGGATAACCAGTGGTCCCTTCGAGCCTGACCTCTAC NM_014792 CCGGTGAGCTTGTGGTGTGGGTTTTCAGGCTGTATCCTTCTACCTCCTGA NM_014686 TGTGAACCAGGATAACAAAACCAAAACGTGGCCACCCAAAGCACCCTGGC AB029034 CAGGCAAACCGCAGCACCACACCTATGGCCCCCGGTGTCTTCTTGACCCA BQ722784 ATCGGTCTTTCTCTTTCAATCCTCACCCGGGATATTTGACCCCTTCCATG NM_198243 CTGTGTGCACGGATGTTATATAATTACGGAGCAGACACGAACACACGGAA NM_016570 GCACATGCCATTCTGGCAGTTTTTTGTAAGACTCTGTGGTATTGTTGGAG BC001077 CCACTGCCCTCTAAGACCTTGGAAGGGGAAACACCAGAAGGTGTGGGTGC NM_138379 ACATTGGAGATAGTAAAAATGTCCTCAATGACGTGCAGCATGGAAGGGAA NM_024319 ATGTTCGGCTCCAGTCGTGGAGGCGTGCGCGGCGGGCAGGACCAGTTCAA AB032991 GGAAGGTATGGTGCTATCTGCGGATTTGGCCTTTCCTTGATCAAATGGAT NM_015670 CCTATTTTGACTCGCAGCGTACCCTAAACCGCCGCTGCCCTAAGCATATT NM_015436 CCTTGCTGTGACAAGCTTTATACTTGCCGCTTGTGTCATGATAACAATGA NM_032263 AAGATTCGGCCACTTACAACAGTCTCCTGCAAGCTTTGAGCAAAGAGAGG NM_021960 AAGGACAAAACGGGACTGGCTAGTTAAACAAAGAGGCTGGGATGGGTTTG NM_000295 TGACCACCGTGAAGGTCCCTATGATGAAGCGTTTAGGCATGTTTAACATC NM_002390 ACCCACGGGGGAGACGGAGAGATATAAAGGTCCCAGCGGCACCAACATCA NM_001706 CTTCCGCTACAAGGGCAACCTCGCCAGCCACAAGACCGTCCATACCGGTG NM_005214 TGCAGCAGTTAGTTCGGGGTTGTTTTTTTATAGCTTTCTCCTCACAGCTG NM_006850 TCCGGAGAGCATTCAAACAGTTGGACGTAGAAGCAGCTCTGACCAAAGCC NM_000418 GGACAGGGAGCCACCTCGCAGTCCGCAGAGCTCACATCTCCCAAGCAGCT NM_002835 CCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGTGGAAAACCCAA NM_002927 CTGGATGGCATGTGAAACCTATAAGAAAATTGCCTCACGGTGGAGCAGAA NM_003005 CTAGGAACATATGGAGTTTTTACAAACGCTGCATTTGACCCGAGTCCTTA NM_005449 TCCAGATGCCTGCATATGCCAGTTCTTCCAAATTCGTAACCAGAGTTACC NM_000075 CAGAGGATGACTGGCCTCGAGATGTATCCCTGCCCCGTGGAGCCTTTCCC NM_004064 AATAAGGAAGCGACCTGCAACCGACGATTCTTCTACTCAAAACAAAAGAG NM_004454 GGAGGACACCCTGCCGCTGACCCACTTTGAAGACAGCCCCGCTTACCTCC NM_001775 GCCAGGATCCCACCATAAAAGAGCTGGAATCGATTATAAGCAAAAGGAAT NM_176783 ACTCAAATCTCTAAGTATTTCTCTGAGCGTGGTGATGCAGTGACTAAAGC NM_016187 TTGTACTTCCCCCACCTTAATGACATCTCAGGTTGCTTCAGAGCCTGGAG NM_006495 GGAGTTCTCTATTCCTCCCAACTCTGATCAAGATCTTAATGAATCCCTGC NM_042066 CTCCATCAAGAGAGCTACTGAAGCATCCAGTCTTTCGTACTACATGGTAG NM_005248 CAGCATCCCTGTACGAGGCCATGGAACAGACCTGGCGTCTGGACCCGGAG NM_032663 AAAGAAGCGTAGAAAAGGGCTTGTGCCTGGCCTTGTTAATTTAGGGAACA NM_000633 CCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGGGCCACAAGTGA NM_005100 AATGGCCAGAAAGGAGCCCTGAACGGTCAAGGAGCCCTAAACAGCCAGGA NM_014207 CATCGCAACCACACGGCAACCGTCCGATCCCATGCTGAGAACCCCACAGC NM_001831 TGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGA NM_006187 ACAGAGCTACAACGGGACTTCATCATCTCTCGCCCTACCAAGCTGAAGAG NM_058176 GCCTGTGGCCAAAGAGTTTGATCCAGACATGGTCTTAGTATCTGCTGGAT NM_002738 GATTTTTCACCCGCCATCCACCAGTCCTAACACCTCCTGACCAGGAAGTC NM_001774 TGTGCAGAAACCTGGACCACGTCTACAACCGGCTCGCTCGATACCGTTAG NM_152866 AAGAAACAGAGACGAACTTTCCAGAACCTCCCCAAGATCAGGAATCCTCA NM_006184 GCCGAGCAGGATCCCAATGTACAGGTGGATCATCTGAATCTCCTGAAACA NM_003955 CCTATGAGAAAGTCACCCAGCTGCCGGGGCCCATTCGGGAGTTCCTGGAC NM_002162 AGAGCACCTATCTGCCCCTCACGTCTATGCAGCCGACAGAAGCAATGGGG NM_000598 AGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGTGAC NM_006472 CCTGAGTTCAAGTTCATGCCACCACCGACTTATACTGAGGTGGATCCCTG NM_005998 CTGTGAGACCTGGGGTGTAAATGGTGAGACGGGTACTTTGGTGGACATGA NM_000884 TGGAAGGTGGCGTCCATAGCCTCCATTCGTATGAGAAGCGGCTTTTCTGA NM_006636 CTGCAAAAAAGGTGCTGAGGCTTGAAGAGCGAGAAGTGCTGAAGTCTAAA NM_000269 AAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCC NM_004619 GCCAAGAACGCCTACATTAAAGATGACACTCTGTTCTTGAAAGTGGCCGT NM_004972 GGGATCTAGCTCTTCGAGTGGATCAAATAAGGGATAACATGGCTGGATGA NM_019841 CTGGGGCACTTGAATCTTGGACTGAACCTTAGTGAGGGGGATGGAGAGGA NM_156039 CGACTGTGTCTTTGGGCCACTGCTCAACTTCCCCCTCCTGCAGGGGATCC NM_002467 AGGAGGAACGAGCTAAAACGGAGCTTTTTTGCCCTGCGTGACCAGATCCC NM_002460 GCAATCCAGAAGATTACCACAGATCTATCCGCCATTCCTCTATTCAAGAA NM_001242 GGGCCCTGTTCCTCCATCAACGAAGGAAATATAGATCAAACAAAGGAGAA NM_001877 TAGAAGCACGAGAAGTATATTCTGTTGATCCATACAACCCAGCCAGCTGA NM_004513 TGGGTGGCACTGCCATGCAGGGCCTCACACGGTTTGAAGCCTGGAACATC NM_007289 CAGAAATGCTTTCCGCAAGGCCCTTTATGGTACAACCTCAGAAACAGCAA NM_018209 GCCCCTCGGAGGGCCACAGTTATCAGAACAGCGGTCTGGACCACTTCCAA NM_002166 TTGGACCTGCAGATCGCCCTGGACTCGCATCCCACTATTGTCAGCCTGCA NM_001882 GAAAACCCAAATGGAAACAGTATCGGGGAATTCTGTTTGTCTGGTCTTTG NM_000698 ACGGTCACCGTGGCCACTGGCAGCCAGTGGTTCGCCGGCACTGACGACTA NM_001923 GCAAACCTACAGTATGACGATGGCAGCGGTATGAAGCGAGAGGCCACTGC NM_031966 ATGCCACATCGAAGCATGCTAAGATCAGCACTCTACCACAGCTGAATTCT NM_001987 AAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAA NM_002574 CTGTTGGCCGCTCTGTGGATGAGACTTTGAGACTAGTTCAGGCCTTCCAG NM_000034 TCCCTTCCCCCAAGTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGG NM_003656 AGATACAGCTCTAGATAAGAATATCCACCAGTCGGTGAGTGAGCAGATCA NM_002168 CCGCGGCGCCACTATGCCGACAAAAGGATCAAGGTGGCGAAGCCCGTGGT NM_005566 CGGAATAAAGGATGATGTCTTCCTTAGTGTTCCTTGCATTTTGGGACAGA NM_003070 GCGGAGGGAAGATGCCCGGAACCCGAAACGGAAGCCCCGTTTAATGGAGG NM_007146 AATGAGACCTGTAGAGAGCATGCCTTTCTTGCCCCAAGCTTTGCCTACAT

TABLE 26 Polynucleotide probe sequences for preparation of a small 30mer nucleic acid array GenBank Accession No. of Oligonucleotide Target gene sequence (5′ to 3′) NM_001728 AAGAACGTCCGCCAGAGGAACTCTTCCTGA NM_018462 GACACTCACTAGAACAGTGCCGTGCTGCTG NM_002266 TACACTTTCCAAGTTCAGGATGGGGCTCCT NM_004310 AGGAGACGAAACAGAAGGAGGCTCTTCTCC NM_006152 CTCCGACACAATGGGCCACCACCAGTGTGA NM_012203 AGGGGAGCCGATGCCTAGTGAACTCAAGCT NM_058197 GGAGTTTTCAGAAGGGGTTTGTAATCACAG NM_000277 CCAGCAGCTTAAGATTTTGGCTGATTCCAT NM_133480 CACTTAGTGCCCACAACCGCACCAAGAAGC NM_002447 TCTCACCCATGCCAGGGAATGTACGCCGGC NM_001197 TGAGGTTCTGGAGATCCCCGAACCCCGGGT NM_030674 CACACATCAGCAATCTCTCACCACTTCTTT NM_004907 AGCGTCATCCGAAGTCGCCGATCGCCTGCA NM_002910 AAAGGCTGCTTCCACGTGCCGCGGTGCCTA NM_001901 AATCGCTGTACTACAGGAAGATGTACGGAG NM_005526 CCCAAAGCCAAGGACCCCACTGTCTCCTAG NM_000852 CTCCCCATCAATGGCAACGGGAAACAGTGA NM_002511 CACAGCATGAAGCAGGAAATGGCAATGTGA NM_000365 CTCAAGCCCGAATTCGTGGACATCATCAAT NM_001891 CCACCCACCAGATCTACCCTGTGACTCAGC NM_006851 CCACGTAACAGATACACTTCTCTCTTTCTC NM_005178 TCAGCTCCAATGGTCTTCTCTCCGCATCAC NM_005582 CTGTGGGATTACAGCCATAGGCATTTTCTT NM_001344 GTTTGCCTGAGAATACAGATCAACCCACAG NM_002086 CCGAGAGAGTGAGAGCGCTCCTGGGGACTT NM_002228 TGATAATCCAGTCCAGCAACGGGCACATCA NM_002961 CTTTGAAGGCTTCCCAGATAAGCAGCCCAG NM_002987 TGCTCCAGGGATGCCATCGTTTTTGTAACT NM_182908 TTGCGGTGGCAGGCTACTCCACTCGGCTCT NM_004434 ACAAGCATCATGCAGTGGCGCGTCATTTAG NM_013451 CAGCCCAACATTTCCAGATACTACCTGCGT NM_002444 ATGACATGATCCATGCTGAGAACATGCGAC NM_002048 TGAGGACTACGATGACGAGCAGCGCACCGG BM722299 GTGGTTCACAACGACAGGCTACTGAGCACC AB033114 TAGGAGAAGCACTGTTGTTTTCCACACAGT NM_004665 GACCAGCAATTCAGCAATAACTTACCTGCT NM_001715 GATGAGCAACCCCGAGGTCATCCGCAACCT NM_001783 AGGAGGGCAACGAGTCATACCAGCAGTCCT NM_001618 GACCGGGATTTCATCTGGTGTGATAGACAC NM_002167 CGGAACTTGTCATCTCCAACGACAAAAGGA NM_006115 GTGGGGACAGAACCTTCTATGACCCGGAGC NM_015055 ACCCTCACCTGATCACTAACTGGGGACCTG NM_000038 AGAGAGGCAGGCGTGAAATCCGAGTCCTTC NM_020992 TATGAAGTGGTCACTGTGTTCCCCAAGTGA NM_005933 ACTGGGGCAAGAACGGAGTTGCTTCTATAA NM_002661 CAGTGTTAATGAGAACCACTCCAGCTGTAC NM_002838 CACCATCACAGCGAACACCTCAGATGCCTA NM_005215 CCAATGTGTATGAACAGGATGATCTGAGTG NM_022743 GAATGCGACGCCAACATCAGAGCATCCTAA NM_004119 TCTCCGCAGGCTCAGGTCGAAGATTCGTAG NM_024408 CACATGTCTGAGCCACCACACAACAACATG NM_000314 CCACTGACTCTGATCCAGAGAATGAACCTT NM_001795 GACTGGGGACCCAGGTTTAAGATGCTGGCT NM_001226 CGCAGGTTTTCAGATCTAGGATTTGAAGTG NM_006763 AAGAACTACGTGATGGCAGTCTCCAGCTAG NM_053056 TGATCAAGTGTGACCCAGACTGCCTCCGGG NM_004126 AGCTTCGCAAAGAAGTGAAGTTGCAGAGAC NM_006579 ATGCTGTGAAGCACCTCACTCATGCCCAGA NM_007360 GTGCACTCTATGCCTCGAGCTTTAAAGGCT NM_030956 GAGGTTCTACAATCTCTCTGATGAGAACAG NM_003254 AACTGCAGAGTGGCACTCATTGCTTGTGGA NM_001760 CCTACAGATGTCACAGCCATACACCTGTAG NM_005225 CTCATCCCTCACCACAGATCCCAGCCAGTC NM_003810 CAGTTTTTTCGGGGCCTTTTTAGTTGGCTA NM_006325 AGAGGTTGCTCAGACAACTGCTCTCCCGGA NM_004225 ACCCACTGATCCAGCCCCCCTACGAGGTCT NM_005781 AAGTGCTGGAGATGTTCGACTGGAACCTGG NM_005243 AGTACTCAGCCGGCAGCATAATGAAAAGTG NM_002648 GATAGGCCAACCTTCGAAGAAATCCAGAAC NM_006769 TGAATTCACTTCAGAGCAATCCACTACTGC NM_004689 AACCGCAGTAACATGAGTCCCCACGGCCTC NM_003403 AACATCTGCACACCCACGGTCCCAGAGTCC NM_002592 TACTTGGCTCCCAAGATCGAGGATGAAGAA NM_005104 TCAGACACCAGTGATTCAGACTCAGGCTAA NM_004762 AAGAAGGTCTCCTCCACGAAGCGACACTGA NM_004475 ATCAAGAAGGCCACTGGTGTGCAGGTGTGA NM_013995 GTGCTGGTCTTTCAGGCTTGATTATCGTTA NM_134269 GAAGGGGCTGGTAAAAACCAAAAAGTCCTA NM_017935 CGACCCCAAGTTGAAAAGGAATTTGGTTTC NM_002129 GCTGCATATCGTGCCAAGGGCAAAAGTGAA NM_181430 GCCAGCTCAGACTGGAGTTGCCTCAGTTGA NM_031844 AGGTAAGAAGAAGGCGGAAGGCGGCGGAGG NM_006819 ATGGATGTGGGTCTGATTGCAATTCGGTGA NM_004941 AGAATATCTCGAGCTTTCCGACGGCGCTGA NM_003352 GAACAAACGGGGGGTCATTCAACAGTTTAG NM_000626 ACAGAGCTGCGAGTCATGGGATTCAGCACC NM_001237 AAGTATCATGGTGTTTCTCTCCTCAACCCA BC011857 TCCCGACGGTGGGTTTGTTCTACTGGGGCC NM_002466 CACACATCTCGGACCCTCATCTTGTCCTGA NM_000424 TGGCTTCAGTGCAAGCAGTGGCCGAGGGCT AB037771 CCAAGCTCTCTTTTCCAGAGAGCAGTGGCT NM_025113 GACTGTTCAACATGCCTTATGATAACACCG NM_032873 GGACCAACTGGGGGCTTCAACTGGAGAGAG NM_023037 GACTCCAGTGTTTCTGGCACTAGTCTCTGA NM_033306 GGCTCTATCTTCATCACACAACTCATCACA NM_003217 GGCTTCGTCCTTGTTGATACTCAACTCATT AF509494 CTTGAGTAAGACAAGTCTGGTGAACGAATG NM_001781 ACAACTGGTTCAACGTTACAGGGTCTGACA NM_002984 GAGTACGTGTATGACCTGGAACTGAACTGA BC025340 CAGCTGTTGGGGAATTACCGATGCCTTTGA NM_030926 GCTCCTCATGAACGTGAAGAGGGGGACCTA AF331856 ACTATACTGACGTCTCCAACATGAGCCGCT NM_000405 AAGATCGCTGCCTCTCTAAAGGGCATATAG NM_000483 AGGGACTTGTACAGCAAAAGCACAGCAGCC NM_001888 CAAACTCATCTATGATTCCTGGTCATCTGG NM_014670 TTGCTGCCTTTACTACTCAAGGTCAGTCTG NM_003804 AGCAGCTTGATTTACGTCAGCCAGAACTAA AB018263 AACTCCACGCTCACTGCCTCGGAGGTCTGA NM_006475 CAATAACTGAAGTGATCCATGGAGAGCCAA NM_001786 GGGGATTGTGTTTTGTCACTCTAGAAGAGT NM_031942 TGAGATACAAGATGGAATGAGGCTGCAGTC NM_001640 AGGGCATGGAGTATTACCGTGCCCTCAAGA NM_002483 GTGGCCACCGTCGGCATCACGATTGGAGTG NM_003915 GCTCCGATTATGACAGTGACGGGTCACATG NM_018842 CCAGTGAGAAGCTTCAGTGGAGAGGCCTAA NM_147180 TATCCTTTGAGGAATTCAGTGCTGTGGTCA NM_000485 TGGCACCTGTACCCTTCTTCTCTCTCCTGC NM_004924 ACGGCCTTGTATGGCGAGAGCGACCTGTGA NM_002276 ATCACTACAACAATTTGTCTGCCTCCAAGG NM_003480 CCTCCCTGTGAAAATGTGGATTTGCAGAGA NM_002023 CTCCAAGGCAATAGGATCAATGAGTTCTCC NM_006216 GTGTTATTCATGGGGCAGATAAACAAACCC NM_001675 AAGGCAAGGGGGAAGAAAAGGGTCCCCTAG NM_021813 TAAGTGTACAACTGACGAACAGCCCAGGAA NM_006565 GAAGACCAGAATACAGGTGCAATTGAGAAC NM_030666 GGTAGCATCCTATTCTTGGGGAGATTTTCT NM_005537 CTTTCGGGCGCGGATTTATAGCAGTAGCAG NM_004235 CCTCGCCTTACACATGAAGAGGCATTTTTA NM_016269 TGCATCAGGTACAGGTCCAAGAATGACAGC NM_006164 TTCTCCTAGTGAATACTCCCTGCAGCAAAC NM_004630 CTCTCCTCACCCAACTCCCTTTGCCTCTCC NM_003222 CCAGCTGATTCTAACAAAACCCTGGAGAAA NM_000700 GCCAAGCCATCCTGGATGAAACCAAAGGAG NM_019846 GAAACACGAAACATACGGCCATAAAACTCC NM_006889 GCCCAGCGTGTTTTTAAAAGTTCGAAGACA NM_032738 AACAGCATCTGTTGTGGCTATCACAGTCCA NM_000417 GCCCCAGCTCATATGCACAGGTGAAATGGA BC019046 TACAGGAACATGATCGGACAGGGGGCCTAG NM_002189 GACTTGGAAAACTGCTCTCACCACCTATGA NM_004827 TGGGGCTTGTGGAAGAATCACGTGGCCTTG NM_001647 TTGGCAAGAAACCCTAATCTCCCTCCAGAA NM_001830 CAGGACCCCGAATCCATCATGTTTAATTAG NM_020944 GGACAGGGCCTATGTTTGGACCAAAGGAAG NM_021643 GGAAGAGAACTTGGACCCTTTCTTTAACTG NM_017784 TGGAAGCCCAAATATTTTATCCAGGAGGGC NM_022366 CTGTATGATGAAACCCTGGAAGATAGGTAG NM_002933 CATATGTGCCAGTCCACTTTGATGCTTCTG NM_022829 TTGGCCAATGACACATTTCGGACCCTCTGA NM_003339 CCTGAGATTGCTCGGATCTACAAAACAGAT NM_005277 TCCAAAGAGCGGCTCAATGCATACACATAA NM_006820 TTCTCATCCTCTCTGCACTGAGGCAGATGC NM_024728 CATCTTCAAGGATCAGCAAGGGTATTACAC NM_025263 CATCCAGGCGTCAATGGACCTCCTCTGTGA BC046632 GTGAACCTGAGCGACTCGGACAAGCAGTGA NM_024713 CCATCTTACTTTGGTTCCAGGATATACTGG NM_000877 TTCATCTAAACACCAGTTACTGTCACCAGC NM_014365 CAGGACAGCCAGGAAGTCACCTGTACCTGA AK092000 CAGTGTACTGAACATACTGTATACCTCGTG NM_022436 CCAGCTCTTGTCATCCTAGGAATAGTTGTT NM_001165 GTGTCCTATTTGTAGGAGTACAATCAAGGG BX647445 CATAAGATTCCAGCTCCTTCAGGTGTTTGA NM_001743 ATCGATGGAGATGGCCAGGTCAATTATGAA BC022095 GTCTTGCGAGGACAGCCTCATAGAGAATGA NM_031305 CGAGAGAGGAAACACAATATGGATTCAGTG NM_006191 GAGAATCCCACCAGTGGGGAAACATTAGAA NM_014792 GTTTTCAGGCTGTATCCTTCTACCTCCTGA NM_014686 AGTGTGGGCCGCAACCAACGACTGCAGTGC AB029034 AGAGACTCGGCCGTATCCTGAAAATCCACA BQ722784 ACCCCAGATGGTGAAACGGCCCAAGCCAAA NM_198243 TAATTACGGAGCAGACACGAACACACGGAA NM_016570 CGTTTCAGACTTGGATCCTATAAACCTGTC BC001077 CGCGGTAGACGAGCGGATGCTGCGCTTTCT NM_138379 GAAGACGAAGACGGCCTTTTTACCCTCTAA NM_024319 TCTCGCAGGTGGCATGACAGAGGCTCTGAG NM_005340 CTTGGAGGTCGGCAAATGCATTGGCCTCCT AB032991 CAGAAACATGTCTGAAAGTATGGCAGCTGC NM_015670 GAGCTGTGTCACTGCAAACTCACTGTGTGA NM_015436 CAAGCTTTATACTTGCCGCTTGTGTCATGA NM_032263 GGCGAGGCACTATGATACGGAGAGAAATTG NM_021960 TAGTTAAACAAAGAGGCTGGGATGGGTTTG NM_000295 GGTCTGCCAGCTTACATTTACCCAAACTGT NM_002390 ATTCGCCGAGGAAGGTCCGGAGGGGCCTAA NM_001706 ACCAAGGTGCAATACCGCGTGTCAGCCACT NM_005214 CCTCACAGCTGTTTCTTTGAGCAAAATGCT NM_006850 GGGAAGTGGACATTCTTCTGACCTGGATGC NM_000418 CTCCGTGGGACCCACATACATGAGGGTCTC XM_034274 CCAGTAGTACTTCAAGAGCTCTCATACTGT NM_002835 CCAAGAGATCCACCTTCAGAATGGACATGA NM_002927 GGATTCCTACCCCAGATTTCTAAAGTCAGA NM_003005 ACAAACGCTGCATTTGACCCGAGTCCTTAA NM_000075 CTACATAAGGATGAAGGTAATCCGGAGTGA NM_004064 GACGGTTCCCCAAATGCCGGTTCTGTGGAG NM_004454 CCCACTTTGAAGACAGCCCCGCTTACCTCC NM_001775 GAGGATTCATCTTGCACATCTGAGATCTGA NM_176783 CAGGGGAGAAACAAAGGGAATGATCTATTG NM_001826 ACGAGGAGTTTGAGTATCGACATGTCATGC NM_016187 CTTCAAGTCTCCATGGTACCAGAAAACAAC NM_006495 CTCTATTCCTCCCAACTCTGATCAAGATCT XM_042066 AAGCATCCAGTCTTTCGTACTACATGGTAG NM_005248 GACTACTTCACCTCCGCTGAACCACAGTAC NM_032663 CCCTCACACCAGTATTTATCCTTAACACTC NM_000633 ACCCTGGGTGCCTATCTGGGCCACAAGTGA NM_005100 CAGGAGGAGAACCGAAATATCGAACAGATT NM_014207 GACTATGATCTGCATGGGGCTCAGAGGCTG NM_005574 GCCTGGACCCTTCAGAGGAACCAGTGGATG NM_001831 GCAGGAATACCGCAAAAAGCACCGGGAGGA NM_006187 GCTGCATGGGACGGAATGGCATCCCCATCC NM_058176 GCCCTTCTAGGAAATGAGCTGGAGCCACTT NM_002738 ACCAGTCCTAACACCTCCTGACCAGGAAGT NM_001774 GTCTACAACCGGCTCGCTCGATACCGTTAG NM_133378 TGGCTCCCTCTTCGACCGTCTGGTCCTCAA NM_152866 CCTCACCAATAGAAAATGACAGCTCTCCTT NM_006184 TTCTCGAGCGGCTCCCTGAGGTTGAGGTGC NM_003955 TTCCTGGACCAGTACGATGCCCCGCTTTAA NM_002162 ACGTCTATGCAGCCGACAGAAGCAATGGGG NM_000598 TGTGGATAAGTATGGGCAGCCTCTCCCAGG NM_006472 ACCACCGACTTATACTGAGGTGGATCCCTG NM_005998 AGAAAGGCGATGACCAGAGCCGGCAAGGCG NM_000884 CTCCATTCGTATGAGAAGCGGCTTTTCTGA NM_006636 GTCTAAAGAGCTTGGGGTAGCCACTAATTA NM_000269 CTGGTAGATTACACGAGCTGTGCTCAGAAC NM_004619 AGATGACACTCTGTTCTTGAAAGTGGCCGT NM_004972 GGATCAAATAAGGGATAACATGGCTGGATG NM_156039 CCCAGGCGATCTGCATACTTTAAGGACCAG NM_002467 CTTGTTGCGGAAACGACGAGAACAGTTGAA NM_002460 CAGATCTATCCGCCATTCCTCTATTCAAGA NM_001242 TGCAGAGCCTTGTCGTTACAGCTGCCCCAG NM_001877 TCTCCTCCTGTGACTCGCTGCCCTAATCCA NM_004513 GATGGACCTGTCACGATTGTCATCAGGAGA NM_007289 AAACAGATGTGCACAGTCCAGGCAATTTCA NM_018209 GATGATGGCTGGGACAACCAGAACTGGTAG NM_001092 AGGTTCTGGAGGACGAAGATGTGTTTCTCC NM_002046 GTGGACCTCATGGCCCACATGGCCTCCAAG NM_002166 CACGGATATCAGCATCCTGTCCTTGCAGGC NM_001882 ATCGGGGAATTCTGTTTGTCTGGTCTTTGA NM_000698 AGCCAGTGGTTCGCCGGCACTGACGACTAC NM_021603 TGACTGGGTTGTCGATGGACGGTGGCGGCA NM_001923 TGGCAGCGGTATGAAGCGAGAGGCCACTGC NM_031966 TAGTTCAAGATTTAGCCAAGGCTGTGGCAA NM_001987 CAGATGAAATCATGAGTGGCCGAACAGACC NM_002574 GACAAACATGGGGAAGTGTGCCCAGCTGGC NM_000034 TCAAATCCAAGGGCGGTGTTGTGGGCATCA NM_004044 TGGCTCCCGGCCAGCTCGCCTTATTTAGTG NM_003656 TGTTGCTGTCGAGACTGCTGCGTGGAGCCG NM_002168 CCGTATTATCTGGCAGTTCATCAAGGAGAA NM_007146 TGCCTTTCTTGCCCCAAGCTTTGCCTACAT

TABLE 27 Polynucleotide probe sequences for preparation of a large 50mer nucleic acid array GenBank Accession Number of Target gene Oligonucleotide sequences (5′ to 3′) NM_000246 GGCTTTCCCCAAACTGGTGCGGATCCTCACGGCCTTTTCCTCCCTGCAGC NM_005175 GGCTGGCATTGGAACCGTGTTTGGCAGCTTGATCATTGGCTATGCCAGGA NM_006559 TGTGGGGAAGATTCTTGGACCACAAGGGAATACAATCAAAAGACTGCAGG NM_030666 CTTTTCTTTATTCGGCATAATTCCTCAGGTAGCATCCTATTCTTGGGGAG NM_003955 CCTATGAGAAAGTCACCCAGCTGCCGGGGCCCATTCGGGAGTTCCTGGAC NM_018209 GCCCCTCGGAGGGCCACAGTTATCAGAACAGCGGTCTGGACCACTTCCAA NM_001165 CAACATTTGACTTGTGTAATTCCAATCCTGGATAGTCTACTAACTGCCGG NM_014670 GTCTGAGCTGACTCTGTTACTGAAGATTCAGGAGTATTGCTATGACAACA NM_144578 CACACCAGGACTCTATCCTACTCCCAGTAATCCTTTCCAAGTGCCTTCAG NM_144628 CGGTTTCGGGGACTTCTGCGGCCTGAAGATCGAACAAAAGATGTCCTGAC NM_032263 AAGATTCGGCCACTTACAACAGTCTCCTGCAAGCTTTGAGCAAAGAGAGG NM_006579 GGGCCACCCTCTCTACTTCTGGTTTTACTTTGTCTTCATGAATGCCCTGT NM_000877 TGGTCAGGGGACTTTACACAGGGACCACAGTCTGCAAAGACAAGGTTCTG NM_002266 CCAGAAACTACCTCTGAAGGCTACACTTTCCAAGTTCAGGATGGGGCTCC NM_018462 GCTCGGGTGACAAAAGGTGAGACACTCACTAGAACAGTGCCGTGCTGCTG NM_002444 CATGCTGAGAACATGCGACTGGGCCGAGACAAATACAAGACCCTGCGCCA AB032991 GGAAGGTATGGTGCTATCTGCGGATTTGGCCTTTCCTTGATCAAATGGAT NM_004762 ATCAGCAGGGACCCTTTCTACGAAATGCTCGCAGCACGGAAAAAGAAGGT NM_000295 TGACCACCGTGAAGGTCCCTATGATGAAGCGTTTAGGCATGTTTAACATC NM_030674 GCCTGCTCATCGAGTAATGGTGAAGGCCACTGAAACCCGCCGAGAAAAAG NM_022743 TGAGACTGGCTTTTGATATTATGAGAGTGACACATGGCAGAGAACACAGC NM_003217 CGTCCTTGTTGATACTCAACTCATTATTGAAAAGGCCGAACATGGAGATC NM_022366 GCGTTCCAAAGATTGTGCTTATAAATGGCTGTATGATGAAACCCTGGAAG NM_014268 CTAATGGACATCCTGTATGCTTCAGAAGAACACGAGGGCCACACAGAAGA NM_003352 CTCTTTGAGGGTCAGAGAATTGCTGATAATCATACTCCAAAAGAACTGGG NM_001923 GCAAACCTACAGTATGACGATGGCAGCGGTATGAAGCGAGAGGCCACTGC NM_033503 TGAGGAACCCCAGCGACTCTTTTATGGCAATGCTGGCTATCGGCTTCCTC NM_001776 CCCTGGTCCTTTTCACAGTGGCCATCATAGGCTTGCTTATCTTTCACAAG NM_178155 AAAGTTCGAGAGAAGATAGAAACGGTCAAGTACCCCACATATCCTGAGGC XM_088315 CCAGTACTACCGGCCCCTGCATGATGAGTACTGTTTCTACAATGGCAAAA AK024458 TTCCCGGTGAGGTCAGGCCTCGTATTACATAAAAATACCTGTGCTGGGAC NM_014397 TGTCACCGGAGAGGATCCATGAGAACGGCTACAACTTCAAGTCCGACATC NM_005969 TTTTTCCGTGAGCGGATAGTCCCGCGGGCTGTGCTGTACTTCACTGGGGA NM_002221 CGGGAGGATGGCTACCTCTCGGGGCTCAATAACCTCGTCGACATCCTGAC NM_013314 TAGATCAACCAAGCCAAATTCCTCAACGCCCGCCTCTCCTCCAGGAACAG NM_004844 TGGGATGATGTTCCCAGTGTTGGGCCCTCGAAGTGAATGCAGCGGGGCCT NM_001759 CAGCAGTACCGTCAGGACCAACGTGACGGATCCAAGTCGGAGGATGAACT NM_001987 AAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAA NM_002827 CTACGGTCCTCACGGCCGGCGCTTACCTCTGCTACAGGTTCCTGTTCAAC NM_004513 TGGGTGGCACTGCCATGCAGGGCCTCACACGGTTTGAAGCCTGGAACATC NM_001237 CTACCTCAAAGCACCACAGCATGCACAACAGTCAATAAGAGAAAAGTACA NM_172164 GGAGGTCAGGAGAAGCAGGGAGAGGTAATTGTGAGCATAGAGGAGAAGCC NM_000424 CCAGTCAAGTGTGTCCTTCCGGAGCGGGGGCAGTCGTAGCTTCAGCACCG AB037771 GCCAACCAGAACTAGACTCTATTTCTACCTGTCCAAATGAGACAGTTTCA NM_025113 AGCCCATTTTCAATTTGCTGAGCATCGGCCAAAGCCTGTATGCGAAAGCC NM_032873 ACCAATCCTTCCTCTTACCCATGGACCAACTGGGGGCTTCAACTGGAGAG NM_023037 TCCTCACTACTTTTCTTCCAGACTCCAGTGTTTCTGGCACTAGTCTCTGA AF509494 AAGAAGAAAGGCGACAGCAACTTCGTAGGAAGGTAGTTGAAATTCTTCCA NM_004556 AGGCTGGTGCCCAGGTAGATGCCCGCATGCTGAACGGGTGCACACCCCTG NM_002984 CAGCCAGCTGTGGTATTCCAAACCAAAAGAAGCAAGCAAGTCTGTGCTGA BC025340 CGCAGCATGGAGTCTGCTCTCAGCTGTTGGGGAATTACCGATGCCTTTGA NM_030926 CCCCTCGCAACTTCTGGGAGCTCCTCATGAACGTGAAGAGGGGGACCTAC AF331856 GGTATTTGGTTTCCCAGTCCACTATACTGACGTCTCCAACATGAGCCGCT NM_000483 CCGCTGTAGATGAGAAACTCAGGGACTTGTACAGCAAAAGCACAGCAGCC NM_001888 CAGCCCACTGTGAGAAGACCACGGTGTTCAAGTCTTTGGGAATGGCAGTG NM_003804 AGCTATCTTTGATAATACCACTAGTCTGACGGATAAACACCTGGACCCAA AB018263 TCAGGACCACCCTGCTGCTTAACTCCACGCTCACTGCCTCGGAGGTCTGA NM_006230 CCGGACACTCTAGGTTGTTACCCCTTCTACAAAACTGACCCGTTCATCTT NM_006475 GCAGTCTTCAGCCTATTATCAAAACTGAAGGACCCACACTAACAAAAGTC NM_001786 AATCCTACAGGGGATTGTGTTTTGTCACTCTAGAAGAGTTCTTCACAGAG NM_031942 CGGCAGCGAGATGGACGGTGTGCGACTGGGGTCCTTGTGTATTTAGCCAA NM_001640 CGCATGGAGAACATTCGATTCTGCCGCCAATACCTGGTGTTCCATGACGG NM_002483 GTGCTCCTGTCCTCTCAGCTGTGGCCACCGTCGGCATCACGATTGGAGTG NM_003915 CACACCCATCCAGGTGCAATGCTCCGATTATGACAGTGACGGGTCACATG NM_018842 AACTCCGCCCGACTGTGACGAATGATCGCTCGGCACCCATCATTCGATGA NM_147180 CCACAATGGGAAACGAGGCCAGTTACCCGGCGGAGATGTGCTCCCACTTT NM_004924 AACCCCTACACCACCGTCACCCCGCAAATCATCAACTCCAAGTGGGAGAA NM_002276 CCTGCTCGAGGGACAGGAAGATCACTACAACAATTTGTCTGCCTCCAAGG NM_002695 GGTGAAGATCATCCGGCCCAGTGAGACGGCTGGCAGGTACATCACCTACC NM_003480 CTGCCCCCTAGGAGACTCCGTCGCTCCAATTACTTCCGACTTCCTCCCTG NM_002023 CAACAATGTCTACACCGTCCCCGATAGCTACTTCCGGGGGGCGCCCAAGC NM_006216 GCCGCTGAAAGTTCTTGGCATTACTGACATGTTTGATTCATCAAAGGCAA NM_021813 GAGAAACTGTTGTCAGAGAGGAATCAACTGAAAGCATGCATGGGGGAACT NM_003651 GCAGGTGAAGCACCAACTGAGAACCCTGCTCCACCCACCCAGCAGAGCAG NM_006565 GAGAGGACGACCCCCTGGCAGAACCAACCAGCCCAAACAGAACCAGCCAA NM_005537 GGGGTGGAGGGTGGACGAGTTGATTTGAACGTCTTCGGGTCGCTCGGCCT NM_004235 CGTGGCCCCGGAAAAGGACCGCCACCCACACTTGTGATTACGCGGGCTGC NM_006235 AAGAGGATAGCGACGCCTATGCGCTTAACCACACTCTCTCTGTGGAAGGC NM_016269 CTATCAACCAGATTCTTGGCAGAAGGTGGCATGCCCTCTCCCGTGAAGAG NM_006164 TCAGCACCTTATATCTCGAAGTTTTCAGCATGCTACGTGATGAAGATGGA NM_003222 CGAACATACAGAACTGCTTGTCTCATTTCAGCCTGATTACCCACGGGTTT NM_000700 GCCATAAGGCATTGATCAGGATTATGGTTTCCCGTTCTGAAATTGACATG NM_019846 GGGCACATCAGGGGAAACACGAAACATACGGCCATAAAACTCCTTATTAG NM_032738 CAGAAACAGCATCTGTTGTGGCTATCACAGTCCAAGAACTGTTTCCAGCG BC019046 TCACCATCTTCATCACACTCTTCCTGTTAAGCGTGTGCTACAGTGCCACC NM_016732 CATCTTTGACTATGATTACTACCGGGACGACTTCTACGACAGGCTCTTCG NM_002189 GAGCGCTGTGTCTCTCCTGGCATGCTACCTCAAGTCAAGGCAAACTCCCC NM_004827 AGGGCATCGATCTCTCACCCTGGGGCTTGTGGAAGAATCACGTGGCCTTG NM_001830 TTGCCCAGAGGAGGGAACTGATTCTCGCAATAAATAACGCCAGACAGAGG NM_020944 CAAACAGGGCACAGGACTAAGGACAGGGCCTATGTTTGGACCAAAGGAAG NM_017784 AGGAACGGAAGCGCGAGAACCTCCGCACACCATGGAAGCCCAAATATTTT NM_002933 TGTGGCCTGTGAAGGGAGCCCATATGTGCCAGTCCACTTTGATGCTTCTG NM_022829 CCTTCCCGGACTGGGCTGATATGTACTCGGTCAATGTCACAGCATTGCCA NM_006399 CCCACGCATTCCACCAACCTCATGTCAGCTCCCCGCGCTTCCAGCCCTGA NM_002893 CCTTCGAATCTCATAAAGATGAAATTTTCCAGGTCCACTGGTCTCCACAT NM_003339 AGATGATCCTTTAGTGCCTGAGATTGCTCGGATCTACAAAACAGATAGAG NM_005277 AATCTCTGCTTGGACCTTCGTCAGTTTGGAATTGTGACAATTGGAGAGGA NM_006820 CAAAGCCGGGTCATGAATGTCCATAAAATGCTAGGCATTCCTATTTCCAA NM_024728 CCCATGGCCCCTTCCTTCATCTTCAAGGATCAGCAAGGGTATTACACAAT NM_025263 GCTTTCACAAGGAACAGAGAAACCCTCGAAGGCTCAAAAGCTGGTCTCTT BC046632 AGCAGTGCCGGTGCATGTCCGTGAACCTGAGCGACTCGGACAAGCAGTGA NM_024713 CAGGCCACCTGCCTGAAAAATTACACCATGATAGTCGAACATATTTGGTT NM_014365 TTGACAGCCTCTTGGCCCGACTGGGCTCTGCCTCGTCTCTCCTCCGCCTG NM_002947 CGCGCATCAACGCCGGCATGCTAGCTCAATTCATCGACAAGCCTGTCTGC AK092000 ATCGAGCATGCTATTCCAGTGTACTGAACATACTGTATACCTCGTGTTAG NM_022436 GCTCAAATGTTTCTGTGACAACTAATCCAATGTGTGCCTTCACTCAAGGA NM_002967 TGATGAACCGAGGAGGAATGTCAGGGCGCGGCAGCTTTGCCCCAGGCGGG BX647445 ACTGTTGCCCTGGCTGTATTCATAAGATTCCAGCTCCTTCAGGTGTTTGA BC022095 CATGCGCACGGGGTTCCTAGCTCCCACGTCTATGTTCACATTTGTGGTCC NM_006808 GCCCTGTTCCAGTATTGGTTATGAGTCTTCTGTTCATCGCTTCTGTATTT NM_031305 CAGACTGTCCACCTATGATAATGTCCATCAACAGTTCTCCATGATGAACC NM_014792 CCGGTGAGCTTGTGGTGTGGGTTTTCAGGCTGTATCCTTCTACCTCCTGA NM_006304 GTAGAGGATGACTTCTCTAATCAGTTACGAGCTGAACTAGAGAAACATGG NM_014686 TGTGAACCAGGATAACAAAACCAAAACGTGGCCACCCAAAGCACCCTGGC AB029034 CAGGCAAACCGCAGCACCACACCTATGGCCCCCGGTGTCTTCTTGACCCA BQ722784 ATCGGTCTTTCTCTTTCAATCCTCACCCGGGATATTTGACCCCTTCCATG NM_198243 CTGTGTGCACGGATGTTATATAATTACGGAGCAGACACGAACACACGGAA NM_016570 GCACATGCCATTCTGGCAGTTTTTTGTAAGACTCTGTGGTATTGTTGGAG BC001077 CCACTGCCCTCTAAGACCTTGGAAGGGGAAACACCAGAAGGTGTGGGTGC NM_138379 ACATTGGAGATAGTAAAAATGTCCTCAATGACGTGCAGCATGGAAGGGAA NM_024319 ATGTTCGGCTCCAGTCGTGGAGGCGTGCGCGGCGGGCAGGACCAGTTCAA NM_015670 CCTATTTTGACTCGCAGCGTACCCTAAACCGCCGCTGCCCTAAGCATATT NM_015436 CCTTGCTGTGACAAGCTTTATACTTGCCGCTTGTGTCATGATAACAATGA NM_001240 AATCCTCGGTCTGGTGGAATCTCCTCGAGATCTGGCAATACAGACAAACC NM_001261 ATGTTTTGGTCAAGTTCACGCTGTCTGAGATCAAGAGGGTGATGCAGATG NM_003095 GCAAATACAGAAGAATACATAGATGGAGCTTTGTCTGGACATCTGGGTGA NM_021102 TGCACCGCCAACGCAGTCACTGGGCCTTGCCGTGCATCCTTCCCACGCTG NM_006819 GCTACCAGCGCTGTATGATGGCGCAGTACAACCGGCACGACAGCCCCGAA NM_032966 AGTTCCGCAGTGACCTGTCGCGGCTCCTGACGAAGCTGGGCTGTACCGGC NM_006284 ATTCGGCTCATCTCCTTAGCTGCCCAGAAATTCATCTCAGATATTGCCAA NM_003199 TTCACCTCCTGTGAGCAGTGGGAAAAATGGACCAACTTCTTTGGCAAGTG NM_030752 ACCTCGAGACAACAAACAAGCAGGGGTGTTTGAACCAACCATAGTTAAAG NM_003299 AGAATGCTTCGCCTCAGTTTGAACATTGACCCTGATGCAAAGGTGGAAGA NM_006758 ATGGACAGCCGATCCACGCCGAGCTGTCACCCGTGACGGACTTCAGAGAA NM_194259 AGTACGAGAAAAGGGTCCGAGCACAAGCCAAGAAGTTTGCGCCCTCATAA NM_003366 CAATGGCAGCAAGTGGAAATTTGGGACATACACCTTTTGTTGATGAGTTG NM_006004 ATGCGAGGGACCATTGCGTGGCCCACAAACTCTTTAACAACTTGAAATAA NM_003374 TGGACAGCAGGAAACAGTAACACGCGCTTCGGAATAGCAGCCAAGTATCA NM_006761 ATTTTTCCGTATTCTACTACGAAATTCTTAATTCCCCTGACCGTGCCTGC NM_005781 AGCTCTTCGGGCTGGGTCTGCGGCCCAGAGGGGAGTGCCACAAAGTGCTG NM_005243 TTAAAAAGTACCCGTACTCAGTACTCAGCCGGCAGCATAATGAAAAGTGG NM_003902 GCTGAGTATTATAGACAACAAGCAGCCTATTATGCCCAGACAAGTCCCCA NM_006769 GAATCGCCTGGTCCCGGGAGATCGGTTTCACTACATCAATGGCAGTTTAT NM_004689 GCTGGCCGGGCCTGCGAGAGCTGTTACACCACACAGTCTTACCAGTGGTA NM_006875 TTCCCAGCCCATGTCTCCCCAGACTGCTGTGCCCTAATCCGCCGGTGCCT NM_002953 CTGGCAGGATATACTCCATTTGCCAACGGTCCCAGTGACACACCAGAGGA NM_004965 AGCTAAACCTCCTGCAAAAGTGGAAGCGAAGCCGAAAAAGGCAGCAGCGA NM_000592 GCAGCCTGTGCCCAGCTCAACGACTTCCTCCAGGAGTATGGCACTCAGGG NM_178014 CGGCCGATACCTCACCGTGGCTGCTGTCTTCCGTGGTCGGATGTCCATGA NM_005742 TCAGGGAGCTCTCTTTTGGGCGTGGCTCCACGGCACCTGTAGGAGGCGGG NM_001901 TGGGCCTGCCCTCGCGGCTTACCGACTGGAAGACACGTTTGGCCCAGACC NM_004907 GGGACGTTGGACTGGTCCCGAGCAAGAAAGCCCGTCTGGAAGAAAAGGAA NM_003070 GCGGAGGGAAGATGCCCGGAACCCGAAACGGAAGCCCCGTTTAATGGAGG NM_001255 ATGAGACCCTGAGGCTATGGCGCTGTTTTGAGTTGGACCCTGCGCGGCGG NM_002417 CCTACGGAAACTGAAATTCACAATGAGCCATTTTTAACTCTGTGGCTCAC NM_006209 ATACATAGGATGGATCATTATGCTGCGGAAACTCGTCAGGACAAAATGAC NM_002162 AGAGCACCTATCTGCCCCTCACGTCTATGCAGCCGACAGAAGCAATGGGG NM_000587 AGACGATGTCTGAGTGTGAGGCGGGCGCTCTGAGATGCAGAGGGCAGAGC NM_031243 GAGGAGGATCTGATGGATATGGCAGTGGACGTGGATTTGGGGATGGCTAT NM_003017 CACTCCGAAGTGTGTGGGTTGCTAGAAACCCACCCGGCTTTGCTTTTGTT NM_004994 AACCAGGTGGACCAAGTGGGCTACGTGACCTATGACATCCTGCAGTGCCC NM_002966 CGCTGGGGATAAAGGCTACTTAACAAAGGAGGACCTGAGAGTACTCATGG NM_001345 CCGGGCTGCATTGTGTATGGTGCCACCTAGAGATCCACGATGACTGCCTG NM_002497 GAACATCATGAGGAGTGAGAATTCTGAGAGTCAGCTCACATCTAAGTCCA NM_000545 GCCTCACGCCCACCAAGCAGGTCTTCACCTCAGACACTGAGGCCTCCAGT NM_006184 GCCGAGCAGGATCCCAATGTACAGGTGGATCATCTGAATCTCCTGAAACA NM_000598 AGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGTGAC NM_006152 AGGACTCATGGACGTCTCTAGAACATATCTTGTGGCCATTTACCAGACTC NM_006274 GACCAGCCCTGGGTAGAACGCATCATCCAGAGACTGCAGAGGACCTCAGC NM_001428 CATCCTGCCAGTCCCGGCGTTCAATGTCATCAATGGCGGTTCTCATGCTG NM_002415 TGCACAGCATCGGCAAGATCGGCGGCGCGCAGAACCGCTCCTACAGCAAG NM_003234 ATGAAACGCTGTTCAGAAACCAGTTGGCTCTAGCTACTTGGACTATTCAG NM_001728 TCGTGAGTTCCTCGCAGGGCCGGTCAGAGCTACACATTGAGAACCTGAAC NM_002460 GCAATCCAGAAGATTACCACAGATCTATCCGCCATTCCTCTATTCAAGAA NM_003403 CCCTCATAAAGGCTGCACAAAGATGTTCAGGGATAACTCGGCCATGAGAA NM_001344 TGGGGAGTTTCATCCTAGCGGTTTGCCTGAGAATACAGATCAACCCACAG NM_002648 CTGTATGATATGGTGTGTGGAGATATTCCTTTCGAGCATGACGAAGAGAT NM_006585 CTTACCTGGGAAAATATTGGGCTATCAAACTCGCTACTAATGCTGCAGTC NM_001826 TATTCGGACAAATACGACGACGAGGAGTTTGAGTATCGACATGTCATGCT NM_002466 TACTCCATGGACAACACTCCCCACACGCCAACCCCGTTCAAGAACGCCCT NM_005582 GCAAACCCGCCATCTCTAAGGGGAGTTAAGCTATCTGATGTCAAGCTTTC NM_001831 TGACTCTGATCCCATCACTGTGACGGTCCCTGTAGAAGTCTCCAGGAAGA NM_000038 CAGGGCCAGTGCAGCACTCCACAACATCATTCAGTCACAGCCTGATGACA NM_001226 GAGACAATCTTACCCGCAGGTTTTCAGATCTAGGATTTGAAGTGAAATGC NM_005190 GAGAGCAGGGTCCAAATGGAAGTCAGAACTCTAGCTACAGCCAATCTTAA NM_001795 ACGTGGATTACGACTTCCTTAACGACTGGGGACCCAGGTTTAAGATGCTG NM_030582 GGGCACCACTCACGGGGCCCTCAGTGCCACCACCATCTTCAGAGCGCATC NM_001848 CGACAACCTGAGGGACAGGTACTACCGCTGTGACCGAAACCTGGTGTGGA NM_004378 CGTTTGGCGCCGATGACGTGGTCTGCACCAGAATTTATGTCCGGGAATGA NM_004380 GCCACGTTGCCTCCGCACAGCCGTTTACCATGAGATCCTTATTGGATATT NM_005215 CCAACAGAGGATTCAGCCAATGTGTATGAACAGGATGATCTGAGTGAACA NM_004948 AGAGGGACTGGAGTTTCTAGATCACCTGGAACCCAAATTTAGGACATTAG NM_001397 AGGCGCTGAGGGAGTCCGTGCTGCATTTGGCCTTGCAGATGTCGACGTAC NM_004448 GCCTCTTAGACCATGTCCGGGAAAACCGCGGACGCCTGGGCTCCCAGGAC NM_001982 AAAAACTCTACGTAGCTTAGAGGCTACAGACTCTGCCTTTGATAACCCTG NM_006137 TCGGCGGCATGTGTGGTGTACGAGGACATGTCGCACAGCCGCTGCAACAC NM_005245 ATGCCCCTTACCCGCCAGGGTATCAAAGACACTTCGAGGCGCCCGCTGTC NM_004119 AGATGGATTTGGGGCTACTCTCTCCGCAGGCTCAGGTCGAAGATTCGTAG NM_182925 GCCGCCAGGTATTACAACTGGGTGTCCTTTCCCGGGTGCCTGGCCAGAGG NM_000629 CTCTCCCGTTTGTCATTTATGCTGCGAAAGTCTTCTTGAGATGCATCAAT NM_001552 GGTGCCTGCAGAAGCACTTCGCCAAAATTCGAGACCGGAGCACCAGTGGG NM_000572 TAAGGGTTACCTGGGTTGCCAAGCCTTGTCTGAGATGATCCAGTTTTACC NM_000640 GGTCTGCTTTTGCGTAAGCCAAACACCTACCCAAAAATGATTCCAGAATT NM_000564 GAAGTCATCTGTTATATAGAGAAGCCTGGAGTTGAGACCCTGGAGGATTC NM_176786 GCATGTTGCTCCCTTCTGTCCTCAGCAAGGCTCGGTCCTGGACATTCTAG NM_000213 GTAAGGACCCAGGAACTAGGCCTGGCCGGAGATGTGGCTGAACGAGGTCT NM_001967 TTGGAGATTGAGTTCAAGGAGACCCAAGCACTAGTATTGGCCCCCACCAG NM_004933 GGACGACCTTCGAGACAATGTCCTCAACTACGATGAGCAAGGAGGCGGGG NM_000224 CTTGGTGATGCCTTGGACAGCAGCAACTCCATGCAAACCATCCAAAAGAC NM_002758 GAATTCCAAAGAACGGCCTACATACCCAGAGCTAATGCAACATCCATTTT NM_002412 CAGCGGAGCCGTGGGCAACTACTCCGGAGGACTGGCCGTGAAGGAATGGC NM_004530 TGAAGAGCGTGAAGTTTGGAAGCATCAAATCCGACTGGCTAGGCTGCTGA NM_002422 TTTCCCTCCAACCGTGAGGAAAATCGATGCAGCCATTTCTGATAAGGAAA BC063294 ACAAGCCGCATACGCACCCAGAGCTTTTCCTTGCAGGAGCGTCAGTTGCG NM_004557 CGGCCCAACCCTGCGATAATGCGAGGAAGATACGGAGTGGCTGCCGGGCG NM_002514 TCATTGGGACCTGCACCTGTCACACCAACTGTCCTAAGAACAATGAGGCC NM_000300 ACCAGTACTATTCCAATAAACACTGCAGAGGGAGCACCCCTCGTTGCTGA NM_001276 AGTGGGTAGGATACGACGACCAGGAAAGCGTCAAAAGCAAGGTGCAGTAC NM_000535 CACTGAAAGGGCTAAACTGATTTCCTTGCCAACTAGTAAAAACTGGACCT NM_015869 GACAGATTGTCACGGAACACGTGCAGCTACTGCAGGTGATCAAGAAGACG NM_002805 GAACGAACTAAATGCTAAAGTTCGCCTATTGCGGGAGGAGCTACAGCTGC NM_000314 GGAAGTCTATGTGATCAAGAAATCGATAGCATTTGCAGTATAGAGCGTGC NM_002868 AGGGGTGCCCAAGCTGCAATCGTGGTTTACGACATTACTAATCAGGAAAC NM_002901 GTTGGAAGCCAAGCTACCAATTACGGGGAAGATCTCACAAAAAATCATGA NM_003821 GTCTTCAGCCTTACCCGGAAATACTTGTGGTTTCTAGATCACCATCTTTA NM_005617 CAGAGCCCTTGCCCGCTCGGGTATGAAGATCGGGCGGATTGAGGATGTCA NM_014624 CCTTCCTGGGGGCCTTGGCTTTGATCTACAATGAAGCCCTCAAGGGCTGA XM_044622 CCAGGAGATTGAAGGACCTAGTGTGAGCATAATGGAAAAAACACAATCAC NM_000602 ATGTTCAGACAGTTTCAGGCTGACTTCACGAGTCTTTCAGACCAAGAGCC NM_003012 AGAAAATGAAAAACCATGAGTGCCCCACCTTTCAGTCCGTGTTTAAGTGA AF311912 ACAAGCTGAACGGTGTGTCCGAAAGGGACCTGAAGAAATCGGTGCTGTGG NM_139276 TCACCTTTGACATGGAGTTGACCTCGGAGTGCGCTACCTCCCCCATGTGA NM_003220 GCCAGGGACTTTGGGTACGTGTGCGAAACCGAATTTCCTGCCAAAGCAGT NM_003225 TGTGCAAATAAGGGCTGCTGTTTCGACGACACCGTTCGTGGGGTCCCCTG NM_003842 AGCACAGTGGGGAAGCCCCAGCTGTGGAGGAGACGGTGACCTCCAGCCCA NM_000546 AGTATTTGGATGACAGAAACACTTTTCGACATAGTGTGGTGGTGCCCTAT NM_138764 GGCCTTCTGGAGCAGGTCACAGTGGTGCCCTCTCCCCATCTTCAGATCAT NM_001328 AAACCGTCAAGCCCGAGGCGGATAGAGACCACGCCAGTGACCAGTTGTAG NM_058197 ATTGGAATCAGGTAGCGCTTCGATTCTCCGGAAAAAGGGGAGGCTTCCTG NM_000594 CCCCCAGAGGGAAGAGTCCCCCAGGGACCTCTCTCTAATCAGCCCTCTGG NM_003810 TAGACATGGACCATGAAGCCAGTTTTTTCGGGGCCTTTTTAGTTGGCTAA NM_001798 ACCCTTTCTTCCAGGATGTGACCAAGCCAGTACCCCATCTTCGACTCTGA NM_002609 AAACCCGAGGTTGCTGACGAGGGCCCACTGGAGGGTTCCCCCAGCCTAGC NM_003005 CTAGGAACATATGGAGTTTTTACAAACGCTGCATTTGACCCGAGTCCTTA NM_002985 GCAGTCGTCTTTGTCACCCGAAAGAACCGCCAAGTGTGTGCCAACCCAGA NM_000964 AGCATATGTTCGGGGATTTGGTGTGCAGTTGGAAATTGGCAGCCATTGAG NM_024408 CAGGACGGGCAGGTAGCTCAGACCATTCTCCCAGCCTATCATCCTTTCCC NM_001465 GATACCTCTGATTTCCCTGTTTCATCAGCAGAGATGAGTCAAGGAACTAA NM_001618 GGTGTAGACGTTCCTCTTGGGACCGGGATTTCATCTGGTGTGATAGACAC NM_078487 GTGCGACAGCTCCTGGAAGCCGGCGCGGATCCCAACGGAGTCAACCGTTT NM_004322 GGACTTCCTCGCCCGAAGAGCGCGGGCACAGCAACGCAGATGCGGCAAAG NM_021960 AAGGACAAAACGGGACTGGCTAGTTAAACAAAGAGGCTGGGATGGGTTTG NM_138578 AGCTTTGAACAGGATACTTTTGTGGAACTCTATGGGAACAATGCAGCAGC NM_004383 CGTCCAGAAGCGGGAGGGCGTGAAGGCGGGTACCAAACTCAGCCTCATGC NM_015583 GCCAGGTAGGTTGGAATGTTCAGTGATGTTCTGTAGTCATATCAGACAGT XM_373407 CCGCCGCAACCTCAGCTACACCTGCCGGTCCAACCGTGACTGCCAGATCG NM_016734 TTGTGACAGGCCGTGACTTGGCGAGCACGACCCTCCCCGGGTACCCTCCA NM_000808 CAACAGTGTCAGCAAGGTTGACAAAATTTCCCGCATCATCTTTCCTGTGC NM_002964 TCTGGTGATAAAGATGGGCTGGCAGCCCACAAAAAAAGCCATGAAGAAAG NM_002965 AGATGCACGAGGGTGACGAGGGCCCTGGCCACCACCATAAGCCAGGCCTC NM_001250 CCAGGAGATCAATTTTCCCGACGATCTTCCTGGCTCCAACACTGCTGCTC NM_003407 TCCTGTCGCTGAGCCCTGACGTGCCCGTGCCATCCGACCATGGAGGGACT NM_003674 GGAGAAGCCCCTACCCTGTGAGCCGGAGCTCATGCCGACCTTTCCCCACC NM_078467 GCATGACAGATTTCTACCACTCCAAACGCCGGCTGATCTTCTCCAAGAGG NM_006145 CCCGAAAGGATTCCCCAGACATCAAGAACCGTACTTGAGCAGGTTCTTCC NM_000122 AGGCGCCCAGCAAACATGTACACCCGCTCTTCAAGCGCTTTAGGAAATGA NM_006712 TGCCGCTACCCTTCGAGGAACTGGAGTCCCAGAGAGGCCTGCCCCAGCTC NM_000175 TGCAGTGGCGAAGCACTTTGTTGCCCTGTCTACTAACACAACCAAAGTGA NM_000162 CCCAGACCAAGATCCCAACTCCCACAACCCAACTCCCAGGTAGAGCAGAT NM_000852 CCTCCCCTGAGTACGTGAACCTCCCCATCAATGGCAACGGGAAACAGTGA NM_005526 TAGAGGAGGCGAGTCCCGGGCGCCCATCTTCCGTGGACACCCTCTTGTCC NM_001540 TGGCTACATCTCCCGGTGCTTCACGCGGAAATACACGCTGCCCCCCGGTG NM_002432 GAACAGTTGACCGCAAGCTGAAACTGGTGTGTGGAAGTCACAGCTTCATC NM_002505 CATCCGCCTCAGGCCAGCAAGTCCAGACCCTCCAGGTAGTCCAAGGGCAG NM_002511 GGGAGGAAGTCCTATCAAGAGAGAGGAACCAGCTACCTACTCAGCTCTTC NM_006170 CTCTGTGAGGATGCCTTCTCTACTGTGCATACCCATGAAATTTAATACAC NM_002910 TTTCAAAGGCTGCTTCCACGTGCCGCGGTGCCTAGCCATGTGCGAGGAGA NM_005281 CTGCCTGCCTCCCACTATGTGGCCACCCGCAAGGGCATTGCCACACTGGC NM_005981 GATTTCGGAATCAGAAGGATCCTAGAGCCAACCCCAGTGCCTTTCTATGA NM_003410 GTTCTTCTGGAATGACCATGGACACAGAGTCGGAAATTGATCCTTGTAAA NM_007146 AATGAGACCTGTAGAGAGCATGCCTTTCTTGCCCCAAGCTTTGCCTACAT NM_002419 CTCGCCCCTTCGCAGCCGCATTGATCCCTGGAGCTTTGTGTCAGCTGGGC NM_001197 GGAGAACATAATGAGGTTCTGGAGATCCCCGAACCCCGGGTCCTGGGTGT NM_000418 GGACAGGGAGCCACCTCGCAGTCCGCAGAGCTCACATCTCCCAAGCAGCT NM_006254 GTGTGGACACGCCACATTATCCCCGCTGGATCACCAAGGAGTCCAAGGAC NM_002166 TTGGACCTGCAGATCGCCCTGGACTCGCATCCCACTATTGTCAGCCTGCA NM_033306 TTGACCATCTGCCTCCGAGGAATGGAGCTGACTTTGACATCACAGGGATG NM_020250 GGGCGGGGTTTAAGAGGACGACAGGTGTCTGTATTGCTCTACCTACCTAA NM_002228 TCCTCCCGTCCGAGAGCGGACCTTATGGCTACAGTAACCCCAAGATCCTG NM_001654 GCAAAATCTCCAGCAACTGCCCCAAGGCCATGCGGCGCCTGCTGTCTGAC NM_004047 GCCGTGGGAGTCTGCTACACCATTTTTGATTTGGGCTTCCGCTTTGATGT NM_000729 CCGGAAAGCTCCTTCTGGACGAATGTCCATCGTTAAGAACCTGCAGAACC NM_006273 CAGAAGGACCACCAGTAGCCACTGTCCCCGGGAAGCTGTAATCTTCAAGA NM_001256 ATCCCAGGAGAGCAGCATGACAGATGCGGATGACACACAACTTCATGCAG NM_004073 TTGTGGCCCGAAATCGTAGTGCTTGTACTTACCTCGCTTCCCACCTTCGG NM_006268 CGTGGCTACCACATGTACTGTCTCACCCCGTCCATGTCTGAGCCCCCTGA NM_002104 GAAATACCAGACTTGGATCAAAAGCAACCTTGTCCCGCCTCATACAAATT AK127132 TTTAAATATGCTCTGGTCTGGGGTCTCTCTGTGAAACACAATCCTCAGAA NM_004422 GGGAAGCAAGTGGGACTAGCGATGGGGGCCCTCCTCCATCCAGAGGCTCA NM_006014 TTGGAGGCGGAAATCGCCCATGGGTCCCTGGCACCAGATGCCGAGCCCCA NM_003824 CAGACACCAAGATCGACAGCATCGAGGACAGATACCCCCGCAACCTGACA NM_002055 GAAGGCCACCTCAAGAGGAACATCGTGGTGAAGACCGTGGAGATGCGGGA NM_005313 TGTGCCTTCTCCATATGAAGTCAGAGGTTTTCCTACCATATACTTCTCTC NM_001513 ATCTCACCCCCTACCCTACCATCAGCTCCATCAACAAGAGGCTGCTGGTC NM_003883 TGGCCAAGACCGTGGCCTATTTCTACGACCCCGACGTGGGCAACTTCCAC NM_005339 GACCTCCAGACACACCATATGAAGGAGGAAGATACCAACTAGAGATAAAA NM_003549 TCAGGGCCCCCTTCAAAAAGCCTGCTGGAGACACAATATCAAAATGTGAG NM_004763 ATGCTCTCTACTTAATAATCCGGATGGTGTGTTACGATGACGGTCTGGGG NM_002301 GCGGAATGGTGTCTCAGATGTTGTGAAAATTAACTTGAATTCTGAGGAGG NM_004993 GCTTCAGGCAGCTGTGACCATGTCTTTAGAAACTGTCAGAAATGATTTGA NM_002790 AGGAGAAGCTGAATGCAACAAACATTGAGCTAGCCACAGTGCAGCCTGGC NM_002971 CAAACTGAAGGACAATTCCGGTTTAGAGGTCGATGTGGCAGAATATAAAG NM_003769 AAGCACCAGCTATGGCTACTCACGGTCTCGGTCTGGGTCAAGGGGCCGTG NM_181314 GCTGCCCTGCTCCACCCCACGTCTGGCCTTCTGTCCACTGTGCTGCAGGA NM_003262 CAGTGACAGGAGGGAAGATGATCGATCCCAGCACAGTAGTGGAAATGGAA NM_006497 TCGCTGGATGAAGCACGAGCCGGGCCTGGGTAGCTATGGCGACGAGCTGG NM_007117 GTCCCAGATCTTTCAATCTGACTGGCTCTCCAAACGTCAGCATCCAGGCA NM_006759 TATTAGAGAACAAGATAGTGTCTGGAAACCTTCGCATCTTGGACCACTGA NM_014232 CCCTGCACCCCCTCCAAACCTCACCAGTAACAGGAGACTGCAGCAGACCC NM_006299 AATCACCGAGGAATCCACAATATACAGAAACGGTACCACTGCAAGGAGTG NM_003427 CCTCACCATCCCCAGTCCTGATGCCGACCTGGCCACATCTGGCACACATA NM_000072 GAGACCTGTGTACATTTCACTTCCTCATTTTCTGTATGCAAGTCCTGATG NM_002211 TGGTTGCTGGAATTGTTCTTATTGGCCTTGCATTACTGCTGATATGGAAG NM_004242 CCGTTGCTTTACTTTTTGCTTCACCGACATAGTCATTATGCCGAAGAGAA NM_005589 CCAATGTTCTCATTCACCGGCTCTCGATCCTCCTTCAGGGGAGACACCAA NM_022067 TAGAACTAGACCTGGAAGTTTCCAGTCCCTTTCTGATGCTCTGTCAGACA NM_001752 TACCGTGCTCGAGTGGCCAACTACCAGCGTGATGGCCCGATGTGCATGCA NM_001793 CGGCAACTTTATAATTGAGAACCTGAAGGCGGCTAACACAGACCCCACAG NM_003159 GTAAACCAAGCTGCGCTCCTGACATACCATGAGAATGCGGCACTGACGGG NM_156039 CGACTGTGTCTTTGGGCCACTGCTCAACTTCCCCCTCCTGCAGGGGATCC NM_004941 ATGAGGAACCCAATGCCTGGAGAATATCTCGAGCTTTCCGACGGCGCTGA NM_021071 CCTGATCCTATAGCTATTGCATCTCTCTCCTTTTTGACCAGTGTCATCAT NM_005665 GCTTCAAGGACAGCTTAACAAGTCTGATTCTAACCAGTATATTGGGGAAC NM_004475 CTGTGCATGCCCTCACAGGCGTGGACCTGTCTAAGATACCCCTGATCAAG NM_002133 AGAGGGAAGCCCCCACTCAACACCCGCTCCCAGGCTCCGCTTCTCCGATG NM_004125 CGAGCGCCCTGCAGCGCTTGGTAGAGCAGCTCAAGTTGGAGGCTGGCGTG NM_002102 TGGTGGGCGATGGCTCGTGTTATTTTTGAGGTGATGCTTGTTGTTGTTGG NM_005318 CCTCGGGGTCCTTCCGGCTAGCCAAGAGCGACGAACCCAAGAAGTCAGTG NM_002108 GAATCAAGACCTCTTTCTCCAACAGCCTTTTCACTGCAATTTCTGCACAA NM_006644 ATTTTGGTGCTGAACCTCCACATCAGAATGGTGAATGTTACCCTAATGAG NM_181430 GCCTCAGAAGGCCCCCATGTGCCAGCTCAGACTGGAGTTGCCTCAGTTGA NM_014780 CCTCACCTTCCATACCCTACAGATTCGCTCCCGGGGTGTGCCCTATGCCT NM_005123 ACGACCACAAGTTTACCCCACTTCTCTGTGAAATCTGGGACGTGCAGTGA NM_000917 CATGACCCTGAGACTGGAAAATTGACCACAGCACAGTACAGAGTATCTAA NM_000869 GACAAGCTGCTATTCCACATTTACCTGCTAGCGGTGCTGGCCTACAGCAT NM_006218 GATGTGTTACAAGGCTTATCTAGCTATTCGACAGCATGCCAATCTCTTCA NM_005084 CCAGGGACCAACATTAACACAACCAATCAACACATCATGTTACAGAACTC NM_002890 GCTCTCACCAAACTGCCCACTTCGTTGCTTGCTGAGACTCTCGGGCCAGG NM_134269 TCTACCGCTGTCTGGTCCAGAAGGGGCTGGTAAAAACCAAAAAGTCCTAA NM_004177 AGATGAAACGAAAAAAGCTGTGAAATACCAGAGTCAGGCCCGGAAGAAAT NM_003242 CCTGTGTCGAAAGCATGAAGGACAACGTGTTGAGAGATCGAGGGCGACCA NM_003451 CACTAACCTTATAATGCACAAGCGAATCCACAATGGCCAGAAACTCCATG NM_019841 CTGGGGCACTTGAATCTTGGACTGAACCTTAGTGAGGGGGATGGAGAGGA NM_003177 TCAGCGGGTGGAATAATCTCAAGAATCAAATCATACTCCTTCCCAAAGCC NM_000277 CGCTACGACCCATACACCCAAAGGATTGAGGTCTTGGACAATACCCAGCA NM_053056 AACAAACAGATCATCCGCAAACACGCGCAGACCTTCGTTGCCCTCTGTGC NM_000873 TATGAGCCTGTGTCGGACAGCCAGATGGTCATCATAGTCACGGTGGTGTC NM_001092 CTTCAGCTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGA NM_004454 GGAGGACACCCTGCCGCTGACCCACTTTGAAGACAGCCCCGCTTACCTCC NM_005225 TTTCAGATCTCCCTTAAGAGCAAACAAGGCCCGATCGATGTTTTCCTGTG NM_001760 ACCCGCCATCCATGATCGCCACGGGCAGCATTGGGGCTGCAGTGCAAGGC NM_004064 AATAAGGAAGCGACCTGCAACCGACGATTCTTCTACTCAAAACAAAAGAG NM_000075 CAGAGGATGACTGGCCTCGAGATGTATCCCTGCCCCGTGGAGCCTTTCCC L27560 CGCCAAGCCCCCCTCAAGGTGGGACAGTACCCCGGACCCATCCACTCACT NM_002467 AGGAGGAACGAGCTAAAACGGAGCTTTTTTGCCCTGCGTGACCAGATCCC NM_001175 ACCTCAGCTGGGAGTGGAACCTGTCGATTAAGAAGGAGTGGACAGAATGA AB007921 GGTGCACAGTGGACATTTGGGGAGCGTTGTGGGTGACCCCCACACAGGCA NM_000724 TGTAACGTCACCCCACTCCAAAGAGAAAAGAATGCCCTTCTTTAAGAAGA NM_005187 GAGGACATAGCCATGGCCCACCACTTCCGAGATGCCTACCGCCACCCAGA NM_002987 GGGGCTTCTCTGCAGCACATCCACGCAGCTCGAGGGACCAATGTGGGCCG NM_001803 AGCGGAGGCATTTTCCTTTTCTTCGTGGCCAATGCCATAATCCACCTCTT NM_014376 GAGCTGGCCAGATACATTGAGACCAGTGCTCACTATGAAGAGAACAAGTC NM_182908 ACGTCAACGGGGAGAACATTGCGGTGGCAGGCTACTCCACTCGGCTCTGA NM_004434 TACCCCTGCTCGCAGTTCAGGGCTCCAAGCCACATCTACGGCGGGCACAG NM_014210 CAAAACAGCTCACAGGACCCAACCTAGTGATGCAATCTACTGGAGTGCTC NM_013451 AATTGGACAAAATAAATTAATTGGCACGGCGACTGTAGCCCTGAAGGACC NM_003088 ATCGTGTTCCGCGGGGAGCATGGCTTCATCGGCTGCCGCAAGGTCACGGG NM_000156 ACGGCAGACACACAAGGTCATCCCCTTGAAAGGCCTGTGGGAGGATGTGG NM_002048 TACGATGAGGACTACGATGACGAGCAGCGCACCGGGGGCGCGGGTGGTGA NM_002051 GACGGTCAAGGCAACCACGTCCCGCCCTACTACGGAAACTCGGTCAGGGC NM_000169 CTTCCCTGGGTAAAGGAGTGGCCTGTAATCCTGCCTGCTTCATCACACAG BM722299 CCTGCTCTCGCACCGTCCGAGCGGAGCTTTCGTTTTCAGTGAGCCAGGTG NM_002224 GTGAAGAACAAGACCGACTACACGGGCCCTGAGAGCTACGTGGCCCAGAT NM_005335 GGGAAGTGATGAGCTTTCCTTTGATCCGGACGACGTAATCACTGACATTG NM_002167 CAGACAGCCGAGCTCGCTCCGGAACTTGTCATCTCCAACGACAAAAGGAG NM_004633 AATACCCTGAGTTTTCAGACACTACGCACCACAGTCAAGGAAGCCTCCTC NM_015187 GGTTTTTTGGACCCCTGAAGTACTATCGCCTTCGCAGTCTGCACCCCGCC NM_015196 AATACTACCCGGGGTTCAACCCGTTTCGCGCCTATATGAACCTGGACATA NM_005556 GTGGCATTGGGCTGACCCTCGGGGGAACCATGGGCAGCAATGCCCTGAGC NM_002752 CAGACAGCAGTCTTGATGCCTCGACGGGACCCCTTGAAGGCTGTCGATGA NM_005933 GTTGCCCCTTCCCCATTAGTACTGGGGCAAGAACGGAGTTGCTTCTATAA NM_005098 AACCACCGCTTAAATCGGACTGGAACTCACTTGATGGGATTATTCGTTAA U50748 GGTGTGCTTTTGACTGACAAGTCAAGGGTATCGTGCCCATTCCCAGCCCC AB033114 CTCCCAAATTCTCCTTATCCACCATTCACATACGACTGACGGCCAAAGGA NM_002499 AGACAGGGCCAATTCCACAGAATCCGTTCGAAATACCCCCAGCACTGACA NM_004289 GCCAGTCAATCCCAACCACTATGCTCTCCAGTGTACCCATGATGGAAGTA NM_005654 TTCGTGCTCAACGCGGCCCAGTGCTCTATGCCGCTGCACGTGGCGCCGTT NM_020992 AAGTGTTAAAGCTCCTGTCACTAAAGTGGCTGCGTCGATTGGAAATGCTC NM_003311 CTGCTGGAACGCGGCCATCGCGCTGGCGCTCATCGATTTCCAGAACCGCC NM_002661 AGAAGATATGTTCAGCGATCCCAACTTTCTTGCTCATGCCACTTACCCCA NM_015568 CAAGGCTCCCTTGATCGGAGGCAGAACTTCACCGTACAGCAGCAATGGGA NM_006115 CCAGCTTACAACCTTAAGCTTCTACGGGAATTCCATCTCCATATCTGCCT NM_080588 GCTAGACAGAGGGGGGATGATCCAGACGGCAGAGCAGTACCAGTTCCTGC NM_021038 GCTGCACAGAAATTAATGCGAACAGACAGACTTGAGGTATGTCGAGAGTA NM_006498 TGAGCGTAAGGGGCGGGTTCAACATGTCCTCTTTCAAGTTAAAAGAATAA NM_014904 GGGGATCTGATAGCCCTTGTGACTTGAAATCACCTAATGCATTTAGTGAA NM_002870 CTGGCCCGGGACATCTTGCTCAAGTCAGGAGGCCGGAGATCAGGAAACGG NM_002972 TGCGGCCCTACAGCAACGTGTCCAACCTGAAGGTGTGGGACTTCTACACT NM_003569 GAAAATGCAGAGGTGCACGTTCAGCAAGCAAATCAGCAGCTGTCAAGGGC NM_015055 AGCCCTCCACCACACAAAGAAGCCCGCCAGCGTCGGAAAGAACTCCGGAA NM_015173 CCATAGTTGACTTTATAAAAAGCACGCTACCCAACCTTGGCTTGGTACAG NM_016021 ACCCAACCTGTAGCTAAGAATACCTCCATGAGCCCTCGACAGCGCCGGGC NM_005573 GGAGAGGAGGTTGCTCAAAGAAGTACAGTCTTTAAAACAACCATACCTGA NM_031407 TTGAAGACTCCTATCGTGAGCTGCATCGCAAATCCCCCGAAGAAATGAAG NM_004665 AGGTGCTGAAAGATGGGCGTTTGGTAAACAAGAATGGATCATCTGGGCCT NM_001783 AACGAGTCATACCAGCAGTCCTGCGGCACCTACCTCCGCGTGCGCCAGCC NM_000626 GCTTCACGGTGAAAATGCACTGCTACATGAACAGCGCCTCCGGCAATGTG NM_006762 AAGTGCGTGTGGCGGTGCTACAGATTGATCAAGTGCATGAACTCGGTGGA NM_002838 CACACCACAGCTCTGCTGCCTTACCTGCACGCACCTCCAACACCACCATC NM_173216 ACCTGCTTGGAAAAGCCACACTGCCTGGCTTCCGGACCATTCACTGCTAA NM_002163 CGGATGTTTCCAGATATTTGTGCCTCACACCAGAGATCATTTTTCAGAGA NM_002339 GTTTGTGGCCACCGGGCATGGGAAGTATGAGAAGGTGCTTGTGGAAGGGG NM_152866 AAGAAACAGAGACGAACTTTCCAGAACCTCCCCAAGATCAGGAATCCTCA NM_006495 GGAGTTCTCTATTCCTCCCAACTCTGATCAAGATCTTAATGAATCCCTGC NM_005246 AGCAAGCAAGAGAGCAAGTAGAAAGAGGATACCGGATGTCAGCTCCCCAG NM_000698 ACGGTCACCGTGGCCACTGGCAGCCAGTGGTTCGCCGGCACTGACGACTA NM_004271 CAAAGAGCTTTTTCTTGACCTAGCTCTCATGTCTCAAGGCTCATCTGTTT NM_001715 TCCTCCTGATGGAAGTTGTCACTTATGGGCGGGTGCCATACCCAGGGATG NM_003254 GGGTTCCAAGCCTTAGGGGATGCCGCTGACATCCGGTTCGTCTACACCCC AK090461 TCCTGAGCCTCTTCTACAGTACCACCGTCACCTTGTTCAAGGTGAAATGA NM_004071 CCAGGAAACGTAAATATTTTCACCACGATCGATTAGACTGGGATGAACAC NM_000757 CCCCTGCCCCGTTTTAACTCCGTTCCTTTGACTGACACAGGCCATGAGAG NM_020548 GACATAAATACAGAACGGCCCGGGATGTTGGACTTCACGGGCAAGGCCAA NM_002017 AGCGACGACCAGTCCCTCTTTGACTCAGCGTACGGAGCGGCAGCCCATCT NM_000206 ATAGCCCCTACTGGGCCCCCCCATGTTACACCCTAAAGCCTGAAACCTGA NM_004559 CTTCAATTACCGACGCAGACGCCCAGAAAACCCTAAACCACAAGATGGCA NM_021975 CTCCCCAATGGCCTCCTTTCAGGAGATGAAGACTTCTCCTCCATTGCGGA NM_138933 CCCCTTCTGTTAGAGAAATTTACATGAATGTACCTGTAGGGGCTGCGGGA NM_005919 GGGGCCCCGGCGACTTTCCTAAGACCTTCCCCTATCCCTTGCTCCTCGCC NM_000026 ATCATTTACTGGATCCTTCTTCTTTCACTGGTCGTGCCTCCCAGCAGGTG NM_000687 TGGGCATGTCCTGTGATGGCCCCTTCAAGCCGGATCACTACCGCTACTGA NM_001621 CGTCAGAAGCCAGACCTTTTCCTGATTTGACATCCAGTGGATTCCTGTAA NM_001647 ATCAAATCGAAGGTGAAGCCACCCCAGTTAACCTCACAGAGCCTGCCAAG NM_001664 CAGAGATATGGCAAACAGGATTGGCGCTTTTGGGTACATGGAGTGTTCAG NM_152862 GGAAGCAGTAGAAGTAACATTTGCAGATTTCGATGGGGTCCTCTATCATA NM_005171 TCTGTTCCAACTCCCATCTATCAGACTAGCAGCGGACAGTACATTGCCAT NM_001519 GGAGAGGCTTTGCTCCCAAGCTCTCCCACCCTCGAAGCTGAGCCTGCCAG NM_000900 TCAATAGGGAAGCCTGTGATGACTACAGACTTTGCGAACGCTACGCCATG NM_001746 CCGTGGCTGTGGGTAGTCTATATTCTAACTGTAGCCCTTCCTGTGTTCCT NM_004347 GCGAAAGAATCGCGTGGCTCATCAAATGTTTACCCAAACACTTCTCAATA NM_005201 TCTTCAACTACCTAGGAAGACAAATGCCTAGGGAGAGCTGTGAAAAGTCA NM_000560 GCTATGCGAAAGCAAGACTGTGGTTTCATTCCAATTTCCTGTATATCGGA NM_004356 TGACCACCTCAGTGCTCAAGAACAATTTGTGTCCCTCGGGCAGCAACATC NM_001769 TCAGTATGATCTTGTGCTGTGCTATCCGCAGGAACCGCGAGATGGTCTAG NM_001827 CCGGCATGTTATGTTACCCAGAGAACTTTCCAAACAAGTACCTAAAACTC NM_000397 AACCCTGAGTAAACAAAGCATCTCCAACTCTGAGTCTGGCCCTCGGGGAG NM_004728 GGAAGGCAGTCGAGGCTTCAGGGGACAGCGGGACGGAAACAGAAGATTCA NM_021907 TTCTTCCTTTCCTCATATAAATGTTTCTCCTCTTCTCCCCGCACATCATC NM_006169 CTGGCTACACAATCGAATGGTTTGAGGTGATCTCGCAAAGTTATTCTTCC NM_004416 TACTGGGCCGGTCCATCCGGCCCTGGCAGGGATGACCGGGATACTGCTGT NM_001948 CTGCTCTGAAGAGACACCCGCCATTTCACCCAGTAAGCGGGCCCGGCCTG NM_001951 GAGTCGAGTTCATCTAAGCCCGTGGTTTTTCCTGTTCCCCCACCTGATGA NM_001961 TGACCACTGGCAGATCCTGCCCGGAGACCCCTTCGACAACAGCAGCCGCC NM_003752 CTACCGCAAAAACGAGGGCTACATGCGCCGCGGTGGCTACCGCCAGCAGC NM_001436 GGACACTTTGTGATTTCCATTAAGGCCAACTGCATTGACTCCACAGCCTC NM_005252 GACATGGACCTATCTGGGTCCTTCTATGCAGCAGACTGGGAGCCTCTGCA NM_000146 CTGGGCTGGGCGAGTATCTCTTCGAAAGGCTCACTCTCAAGCACGACTAA NM_012197 TACAGGACTTGGAACACCATTTAGGGCTTGCCCTCAATGAGGTGCAGGCA NM_000435 TCCCAGTGAGCACCCTTACCTGACCCCATCCCCCGAATCCCCTGAGCACT NM_005890 CAATATGGAGAACAGCTTTGACGATGTTTCTTGCCTCTCTCCCCAGAACC NM_002065 GAAGATCGTCGCCCCTCTGCCAACTGCGACCCCTTTTCGGTGACAGAAGC NM_002080 AATTGGCATGTTCTGTTTCACAGGGCTAAAGCCTGAACAGGTGGAGCGGC NM_002092 CAAGGATCGGTCCCACGTTCATCATAGGTATATTGAACTGTTCCTGAATT NM_004493 TGGCTCCCATAGGTATCCGGGTGATGACCATTGCCCCAGGTCTGTTTGGC NM_004964 AATGCTGCCGCACGCACCTGGGGTCCAAATGCAGGCGATTCCTGAGGACG NM_004494 AAAAGAATAGCACCCCCTCTGAGCCCGGCTCTGGCCGGGGGCCTCCCCAA NM_002129 GCTATGACAGGGAGATGAAAAATTACGTTCCTCCCAAAGGTGATAAGAAG NM_031266 TATGGCTATTACGGCTACGGCCCCGGCTACGACTACAGTCAGGGTAGTAC NM_014413 CTCAAGACAAAGGGGTGAGGGATGACGGAAAGGATGGGGGCGTGGGATGA NM_198336 GCTTTTCTAGCTACGCTGATCACGCAGTTTCTCGTGTATAATGGTGTCTA NM_000212 ATAAAGAGGCCACGTCTACCTTCACCAATATCACGTACCGGGGCACTTAA XM_290793 CATCCATCTGGCAGATTGGAAGCGGGGAAGGAATGAAGCGTGTCCTGACT NM_005956 GGACGGCCCAGTTTGATATCTCTGTGGCCAGTGAAATTATGGCTGTCCTG NM_005962 GAGAGTGTGAACATGGCTACGCCTCTTCATTCCCGTCCATGCCGAGCCCC NM_000265 CGCCTCAGCCAGGACGCCTATCGCCGCAACAGCGTCCGTTTTCTGCAGCA NM_005601 GCCAACAGGGCATGGGGACATCATATCAGGCTACATCCACGTGACGCAGA NM_002512 GAAGAACTGGTTGACTACAAGTCTTGTGCTCATGACTGGGTCTATGAATA NM_000270 TTGTCTCCATTCTTATGGCCAGCATTCCACTCCCTGACAAAGCCAGTTGA NM_004152 TAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCGG NM_001604 TGCAGATGCAAAAGTCCAAGTGCTGGACAATCAAAACGTGTCCAACGGAT NM_002541 CCAACTTCGACATCAATCAGCTATATGACTGCAATTGGGTTGTTGTCAAC NM_013232 GAGGTTGACGGATATATTCAGACGTTACGACACGGATCAGGACGGCTGGA NM_021129 TCTGCCTGCACAGTACCAACAGACGTGGATAAGTGGTTCCATCACCAGAA NM_001198 AAGAGAAGTGTACATACATTGTGAACGACCACCCCTGGGATTCTGGTGCT NM_006406 TTGGGCCAATAAGGATTCCACTTCTTTCAGATTTGACCCATCAGATCTCA NM_002836 GTCAAGAGCCTGCGGCTACAGAGGCCACACATGGTCCAGACACTGGAACA NM_002871 GACCAATTGGCTGGCATTGCCTAGATGACAAGAACAGTTTCTATGTGGCC NM_002881 AATCACAGAACATGAATCCTTTACAGCAACTGCCGAATTCAGGGAACAGA NM_005777 AACCAGCAAAAGACAGTCCAACGAGACTTATCGAGATGCTGTTCGAAGAG NM_004159 CTTCTAGTCTTCTGGTTGAAGCTGCGCCTTTAGATGACACGACCCTACCC NM_002923 AGAACAACTCTTATCCTCGTTTCTTGGAGTCAGAATTCTACCAGGACTTG NM_000976 CTGGGGACTGCCCAGTCAGTGGGCTGTAATGTTGATGGCCGCCATCCTCA NM_000983 GAAGAAGAATAATCTACGTGACTGGTTGCGCGTAGTTGCTAACAGCAAAG NM_000969 CCTCACAGTACCAAACGATTCCCTGGTTATGATTCTGAAAGCAAGGAATT NM_000970 CTCCAGGGCTACCTGCGATCTGTGTTTGCTCTGACGAATGGAATTTATCC NM_000661 GTTATCCAGGAGAATGGGTCTCTTGTTGAAATCCGAAATTTCTTGGGTGA NM_002951 CATCCTTCACCCCTGTAGGGGATGTTTTTGAACTAAATTTCATGAACGTC NM_001028 ACAGAGCTCAAGTAATTTACACCAGAAATACCAAGGGTGGAGATGCTCCA NM_001031 TGGAATTCATGGACGACACGAGCCGATCCATCATCCGCAATGTAAAAGGC NM_001007 CCTGTGTATGGTGACTGGAGGTGCTAACCTAGGAAGAATTGGTGTGATCA NM_001009 ACTCCACACGCATTGGGCGCGCCGGGACTGTGAGACGACAGGCTGTGGAT NM_001011 ATTGTGGGCAAGAGAATCCGCGTCAAACTAGATGGCAGCCGGCTCATAAA NM_001013 TGCTGCGGCGGCTGGTCCGCATTGGGGTGCTGGATGAGGGCAAGATGAAG NM_003011 TCGGCGCAGGCGGCCAAAGTCAGTAAAAAGGAGCTCAACTCCAACCACGA NM_006427 TGGACCACGTGTGGGATGAAGGCTGTGCCGTCGTTCACCTGCCAGAGTCC NM_001636 TTCTTCAAGGGTGCGTGGTCCAACGTCCTGCGGGGCATGGGGGGCGCCTT NM_006516 GCTTCCGGCAGGGGGGAGCCAGCCAAAGTGATAAGACACCCGAGGAGCTG NM_002860 ATGCCAGCACTCGCTTTTCTGATGGTTACCGCTTTGGACTGGGAGCTGAA NM_003134 ATTCCAAAGAAAGGTACTGTGGAGGGCTTTGAGCCCGCAGACAACAAGTG NM_006280 ATCGGCCTTGTGATCTACTACTTGGCCTTCAGTGCGAAGAGCCACATCCA NM_003153 CAATCTGGGATCTCAATGTCCCACATGGACCTAAGGGCCAACCCCAGTTG NM_005801 ACAGGGTGACCAACGCAAGAACATATGCCAGTTCCTCGTAGAGATTGGAC NM_003258 ATTGGGGGAGCAGACAAGTACCACTCCGTGTGTCGGCTCTGCTACTTCAA NM_014220 GGAATGGAATGTATCTCTGTTTTCTATCCTCTTGGCTCTTGGTGGAATTG NM_003318 TAAAGAATGACTTTCCACCTGCTTGTCAGTTGTCAACACCTTATGGCCAA NM_006000 CACCACCTTCTTCTGTGAAACTGGTGCTGGAAAACACGTACCCCGGGCAG NM_006009 CCTCGATATTGAGCGTCCAACCTATACTAACCTGAATAGGTTAATAGGTC NM_006002 ATGGAGCGCGACCCTGATGAACTAAGATTTAATGCGATTGCTCTTTCTGC NM_000375 ATCAAATTAAGTTTGCAGCCATCGGCCCCACTACGGCTCGCGCGCTGGCC NM_003380 GGACATTCCTGATTAAGACGGTTGAAACTAGAGATGGACAGGTTATCAAC NM_000377 CCCCTATTGTGGGGGGTAACAAGGGTCGTTCTGGTCCACTGCCCCCTGTA NM_005080 TGTCCTCTCTGCTTGGTGTAAACCATTCTTGGGAGGACACTTTTGCCAAT NM_153380 TCCCCCATAGCCCTTCCTCTACTAAGAATGAGAATGCTAAAACAGGAGCA NM_012203 CATCAGCAGGGGCGACGTCGTAAACCAGGACGACCTGTACCAGGCCTTGG NM_001785 CGTGTACATGACCAAGCCGGATGGTACGTATATTGTCATGACGGTCCAGG NM_002341 GGGGCGAGAGGGTGTACGTCAACATCAGTCACCCCGATATGGTGGACTTC NM_001152 CCGGGTTGACTTCCTATCCATTTGACACCGTTCGCCGCCGCATGATGATG NM_144488 GGGCCCTACAGAGATGCTCCGAGGCATGTACCTCACTCGCAACGGGAACC NM_021966 GAAGCAGCACGCCTGGCTGCCCTTAACCATCGAGATAAAGGATAGGTTAC NM_002350 TTATGTGAGAGATCCAACGTCCAATAAACAGCAAAGGCCAGTTCCAGAAT NM_001774 TGTGCAGAAACCTGGACCACGTCTACAACCGGCTCGCTCGATACCGTTAG NM_013230 CAGCCAGTCTCTTCGTGGTCTCACTCTCTCTTCTGCATCTCTACTCTTAA NM_006325 GCACAGTATGAGCACGACTTAGAGGTTGCTCAGACAACTGCTCTCCCGGA NM_005340 AATGTGCTGCTGATCTGGGCCTGAATAAGGGTTATCGAATGGTGGTGAAT NM_002046 ACAGCAACAGGGTGGTGGACCTCATGGCCCACATGGCCTCCAAGGAGTAA NM_000334 TGCTTGCCAACACCATGAGCAAGATGTATGGCCACGAGAATGGGAACAGC NM_000484 GTGGTTCGAGAGAAGTGGTATAAGGAAGTACATTCTGGCCAGGCACGATG NM_170662 GATAGCCCAGAATAATGTCGAAGTTGCCCGGAGCATCCTCCGAGAATTTG NM_006904 CCATGACCTCCAGGTTAGGATTAATTGAGTGGCTTGAAAATACTGTTACC NM_133480 GCTAATTGCCCAGGGCCTTTTGGAGTCTGAGGACCGCCCCGCAGAGGACT NM_000633 CCCTGGTGGGAGCTTGCATCACCCTGGGTGCCTATCTGGGCCACAAGTGA NM_002086 TTTCTTATCCGAGAGAGTGAGAGCGCTCCTGGGGACTTCTCCCTCTCTGT NM_005248 CAGCATCCCTGTACGAGGCCATGGAACAGACCTGGCGTCTGGACCCGGAG NM_002447 AACAGCCGCAGTTCTCACCCATGCCAGGGAATGTACGCCGGCCCCGGCCA NM_003656 AGATACAGCTCTAGATAAGAATATCCACCAGTCGGTGAGTGAGCAGATCA NM_138980 AAGACTAAAAATGGTGTAGTAAAAGGACAGCCTTCTCCTTCAGCACAGGT NM_016072 TAGAAGAGTGCCAGTCCTTGGATCCCTCCTAAATTTACCTGGAATTAGAT NM_000785 CACGGTGTCCAACACGCTCTCTTGGGCTCTGTATGAGCTCTCCCGGCACC AF200348 GTTCAAGCGCCTGCGAGATGGGGACAGGTTGTGGTATGAGAACCCTGGGG BC060842 GGGACATGTGAATTATATCCATGGAAGCAGTCAAGCCCAGTTTGTAGCTG NM_006302 TTTGGGAGCAGTACAGTGACCGCGATGGGCGAGGCATGTGCCGCCCTTTC NM_020199 GGAATACCATCGCCTAGATCAGAATGTTAATGAGGCAATGCCTTCTTTGA NM_024006 CTGCATTGTTTGTATCACCACCTATGCTATCAACGTGAGCCTGATGTGGC NM_002229 AAGGTGAAGACGCTCAAGGCCGAGAACGCGGGGCTGTCGAGTACCGCCGG NM_024099 CCCCTTCAAAGCCAGCCAGGACTAGTGAACCACAGCTCAAAAGGCAAAAG NM_006378 CGGATAGGGAGGACTCACAGAGGATCGACGACCTTTCTGCCAGGGACAAG NM_033334 CTGCCCCTCCTCTTTAAGGTGGTGCTGCATTCCTGCAAGACCAGTGTGGG NM_002814 ACACTGAGGGTAACACTCCTCTACACTTAGCCTGTGATGAGGAGAGAGTG NM_017771 CCACAAACAGTACTATTTTGCAGATGCTCATGTAAGCAGCTTTTCGAGAG NM_003002 TGGGGCCTTGGACAAGTTGTTACTGACTATGTTCATGGGGATGCCTTGCA NM_003627 GTGTTCGCCTTGCTTCAGCAGCCACTTTTCATGGCGATGGTGGGACCCCT NM_005638 TGTCACCTTCAAAACTACCAGCAGAAATCTTGCTCGAGCCATGTGTATGA NM_003288 CAGACCTCTACAAGAAGACTCAGGAAACTCTTTCACAGGCAGGACAGAAG NM_003302 TTCTTTGGTGTTCACTGGCATTTTGGGGGTGCACTGGCACTTTGGAACAA NM_016308 GCTTCGTGATGAAAGGAAGAACCCAGATTCACAGTATGGTGAACTTATTG NM_006113 CATTTCTCACGGCCTGTTGTGAGACGTTTGGAATGAGGAAAAGTGAACTT NM_006802 CATGGCATGAGGTGTTTGGGCATCCCAAATACTGCTCACTTTGCTAATGT NM_004184 AAACCAAGGTCAATAAGCATGCGTTTTCTGGAGGGAGAGACACCATCGAG NM_000089 AAGAGGGGAACGCGGTCCCCCAGGTGAGAGTGGTGCTGCCGGTCCTACTG NM_004951 ACGGCAAGTCAGTGTATCGATTTCTAGTGCTGTGAAGTCAGCCCCTGAAG NM_002600 GAAAGTTACTGGTGAATAAAAGCATTCGGCAGCGTCGTCGCTTCACTGTG NM_005178 GAGTGCCAAGAAACCGTGCAGCTCTTGCTAGAGCGCGGTGCCGACATCGA NM_001753 ATTCAGTGCATCAGCCGTGTCTATTCCATCTACGTCCACACCGTCTGTGA NM_002414 GGAATGCCAACGCAGAGCCAGCTGTTCAGCGTACTCTTTTAGAGAAATAG NM_001788 AACAAGAATAAAGGGCAGCTGACTAAGAGCCCTCTGGCACAAATGGAAGA NM_004067 GAGTCTCTGGGTTCACTGAACACATTGAAGATGTCAAAATGGCATTTGAC NM_016184 GCTGCGTTGTGCTAAATTTTCGTAAATCACCCAAAAGATGGGGCTGGAAT NM_005627 TCCCCAACTCCATTGGCAAGTCCCCTGACAGCGTCCTCGTCACAGCCAGC NM_006329 AGGGCAGAGAATTTTACATGCGGCAAACGGGCCCCATCAGTGCCACCCTG NM_016195 GAGGAGGACTTGGTGAAATGTGAAAATAAGAAGAATGCTACACCCAGAAC NM_006310 CTGGGAAGAACTTTATAACCGATACCAGGGAGGATTCTTAATATCCAGAC NM_003707 AACAGATCATTAAAATCCGTGCCCAGACGGAAGGAATCAACATCAGTGAG NM_001845 ACGCTTACAGCTTTTGGCTCGCCACCATAGAGAGGAGCGAGATGTTCAAG NM_006803 AACATAACATCAGTTTCCGGGACAGTAGTTCCCTTGGACGCTTTGAAATA NM_001219 TGGGAGGAGTATAAAAATGCCACCTACGGCTACGTTTTAGATGATCCAGA NM_001260 GCGTTCCAATCCACATGCTGCCTATCCCAACCCTGGACCAAGCACATCAC NM_001916 CTGGGCATCTGAGCCAGAGCACGACCATCGAAAACGCATGGGGCTCAAGA NM_000121 GGCTCCCGCCGCCTGAGACACCCATGACGTCTCACATCCGCTACGAGGTG NM_002394 AGCGCTCCCTACTGCATGGGGACTTCCACGCGTTCTCCGCTGGGCCTGGA NM_004483 GGAAAGTGTGAAAGCTGCTAGTGAACTCTATTCTCCTTTATCAGGAGAAG NM_000521 CTGACAAGGCACCGCTGCAGGATGGTCGAACGTGGAATAGCTGCACAACC XM_167711 GAAAGCGCAGTCCTGAAAGTCAGGTCACGATTATGGGCCCACACCTTCCT AL833311 ACTCATATTCTCGGTGTCCTGCTATCACACAGAACAACTTTCTAACCTAG NM_013995 CTAGTGTTGCTGGCTTATTTTATTGGTCTCAAGCACCATCATGCTGGATA NM_024321 CCTTCGTCCCCCACGTGCTACAGAGAGCAGATTCCGCTCTCTCCTCTGCA NM_000946 CTAAAACAGGTCGCATCTCTGTGCCTATTGATTTGCAGAAAGTGGACCAG NM_004176 GGGGACTGGTCCGTGCTCAGTACCCCATGGGAGAGCCTGTACAGCTTGGC NM_002958 AGCAGCTGGTACAGTGCCTAACAGAGTTTCATGCAGCCCTGGGGGCCTAC NM_005063 AAGGCCGCCATCTTGGCCAGGATTAAAAGAACCGGAGATGGAAACTACAA NM_003132 AGTCTCTTCAAGGAGTCCTATTACCAGCTCATGAAGACAGCCCTCAAGGA NM_005100 AATGGCCAGAAAGGAGCCCTGAACGGTCAAGGAGCCCTAAACAGCCAGGA NM_021822 AACCTTGGGTCAGAGGACGGCATGAGACTTACCTGTGTTATGAGGTGGAG NM_020993 GGGGGATCTGGAAGGAGTGCCACCCTCTAAAAAGATGAAACTGGAGGCCT NM_015099 CAGGCAGCTGCTCGGGGTCCCCCACCACAGTCAGTAGCAGGTGGGAGAAG NM_005127 ACCTCAGCGATGATGGTGCAGCAACAGCTAGATGTTACACCGAAAGAAAA NM_004010 AGACATTTAATTCTCGTTGGAGGGAACTACATGAAGAGGCTGTAAGGAGG NM_002305 GCGGGAGGCTGTCTTTCCCTTCCAGCCTGGAAGTGTTGCAGAGGTGTGCA NM_000237 GACTGAGAGTGAAACCCATACCAATCAGGCCTTTGAGATTTCTCTGTATG NM_006187 ACAGAGCTACAACGGGACTTCATCATCTCTCGCCCTACCAAGCTGAAGAG NM_005419 TTGCCCTGTGATCTGAGACATTTGAACACTGAGCCAATGGAAATCTTCAG NM_002390 ACCCACGGGGGAGACGGAGAGATATAAAGGTCCCAGCGGCACCAACATCA NM_016187 TTGTACTTCCCCCACCTTAATGACATCTCAGGTTGCTTCAGAGCCTGGAG NM_014207 CATCGCAACCACACGGCAACCGTCCGATCCCATGCTGAGAACCCCACAGC NM_005214 TGCAGCAGTTAGTTCGGGGTTGTTTTTTTATAGCTTTCTCCTCACAGCTG NM_003564 GCTGATGAATCTGGGTGGGCTGGCAGTAGCCCGAGATGATGGGCTCTTCT NM_002002 AGCCAGCGAAGGTTCCGCGGAGTCCATGGGACCTGATTCAAGACCAGACC NM_004001 CCAAGGCCCCAGACTAAGGACGGCAGCGAAGCAGAGCTCCCTCGTTGGTG NM_058176 GCCTGTGGCCAAAGAGTTTGATCCAGACATGGTCTTAGTATCTGCTGGAT NM_001558 ATCTGACTGGAGCTTTGCCCATGACCTTGCCCCTCTAGGCTGTGTGGCAG NM_006850 TCCGGAGAGCATTCAAACAGTTGGACGTAGAAGCAGCTCTGACCAAAGCC XM_042066 CTCCATCAAGAGAGCTACTGAAGCATCCAGTCTTTCGTACTACATGGTAG NM_033004 CCAGCCAGCCGTGGAACCTCAGGTGCAACAGAGACGCCAGGAGATACTAG NM_002835 CCAACAGAAGCCACAGATATTGGTTTTGGTAATCGATGTGGAAAACCCAA NM_000593 GCAGCTCCTGTACGAAAGCCCTGAGCGGTACTCCCGCTCAGTGCTTCTCA NM_002927 CTGGATGGCATGTGAAACCTATAAGAAAATTGCCTCACGGTGGAGCAGAA NM_005012 GCATCTTTACTAGGAGACGCCAATATTCATGGACACACCGAATCTATGAT NM_000655 CATGGTTACTGCATTCTCTGGGTTGGCATTTATCATTTGGCTGGCAAGGA NM_005449 TCCAGATGCCTGCATATGCCAGTTCTTCCAAATTCGTAACCAGAGTTACC NM_133378 TAATATCCTCTGGGGTACAGTCATGTATAACAAGTTTTCTGACCCTGCCA NM_032663 AAAGAAGCGTAGAAAAGGGCTTGTGCCTGGCCTTGTTAATTTAGGGAACA NM_030753 TGTTAGTGTCCAGGGAGTTCGCGGATGCGCGCGAGAACAGGCCGGACGCG NM_017935 CAAGACAGAGCTCGGATAGAGAGTCCAGCCTTTTCTACTCTCAGGGGCTG NM_003202 AGACAGGTGGCCTAGCAGGCACAGGACACCTGGCCGCCTCCAGGAGCCTA NM_030764 TGATGCCGGCAAATATTACTGTAGAGCTGACAACGGCCATGTGCCTATCC NM_023109 GTGGGCCAGTCTACTGGGAAGGAGACCACTGTCTCGGGGGCTCAAGTTCC NM_002738 GATTTTTCACCCGCCATCCACCAGTCCTAACACCTCCTGACCAGGAAGTC NM_006472 CCTGAGTTCAAGTTCATGCCACCACCGACTTATACTGAGGTGGATCCCTG NM_000417 TTATTATCAGTGCGTCCAGGGATACAGGGCTCTACACAGAGGTCCTGCTG NM_001775 GCCAGGATCCCACCATAAAAGAGCTGGAATCGATTATAAGCAAAAGGAAT NM_005574 TGTGCGAACAGGACATCTACGAGTGGACTAAGATCAATGGGATGATATAG XM_034274 CTCTAGAACTTATTGAATCTGATCCTGTAGCATGGAGTGACGTTACCAGT NM_001706 CTTCCGCTACAAGGGCAACCTCGCCAGCCACAAGACCGTCCATACCGGTG NM_000902 CAGAAATGCTTTCCGCAAGGCCCTTTATGGTACAACCTCAGAAACAGCAA NM_001102 ACACCGGCCCCGACTCCGTGCCAGGTGCTCTGGACTACATGTCCTTCTCC NM_001718 CCCGAGTATGTCCCCAAACCGTGCTGTGCGCCAACTAAGCTAAATGCCAT NM_033554 GGACCAGCCGCTCCTCAAGCACTGGGAGGCCCAAGAGCCAATCCAGATGC NM_002122 AGGAGACTGTCTGGTGTTTGCCTGTTCTCAGACAATTTAGATTTGACCCG NM_019111 TAACTGTGCTCACGAACAGCCCTGTGGAACTGAGAGAGCCCAACGTCCTC NM_002124 GGAGCACCCAAGCGTAACGAGCGCTCTCACAGTGGAATGGAGAGCACGGT NM_014745 CGTCCTCCCTATCAGACGACCAGGTACCCGAGGCTTTCCTGGTCATGCTG NM_006993 TCCCGGCCCCGGTCACTATGGACAGTTTTTTCTTCGGCTGTGAGCTCTCC NM_014366 GAGCATAAGAGCCATCAAGGGCCCTCATTTGGCCAATAGCATCCTTTTCC NM_003255 AGTGCAAGATCACGCGCTGCCCCATGATCCCGTGCTACATCTCCTCCCCG NM_002658 ACAAGGACTACAGCGCTGACACGCTTGCTCACCACAACGACATTGCCTTG NM_002704 CTTGTATGCTGAACTCCGCTGCATGTGTATAAAGACAACCTCTGGAATTC NM_000090 TTCTCCCCAGTATGATTCATATGATGTCAAGTCTGGAGTAGCAGTAGGAG NM_002026 CTGAGAGATGGACAGGAAAGAGATGCGCCAATTGTAAACAAAGTGGTGAC NM_001766 GCTTTACCTCCCGGTTTAAGAGGCAAACTTCCTATCAGGGCGTCCTGTGA NM_006614 TGGTGCCTACGCTGGATCTAAGGAGAAGGGATCTGTTGAAAGCAATGGAA NM_004445 TACTGGGACATGAGTGAGCAGGAGGTACTAAATGCAATAGAGCAGGAGTT NM_006058 CCAGGCCTACAGAACCAGAGCCAGCTGATCTCAGATTGCCAAGAAACTAG NM_052938 GGGACACATATGGAGGACAAGGTTTCCTTAGACATCTATTCCAGGCTGAG NM_004126 GGGAATTCCAGAAGACAAGAACCCCTTTAAAGAAAAAGGCAGCTGTGTTA NM_007360 TGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCAGCCTTCTGAAAGTAT NM_004225 GAAGATCAAAGACAACCCACTGATCCAGCCCCCCTACGAGGTCTGCATGA NM_005940 AAGGCTTCCCCCGTCTCGTGGGTCCTGACTTCTTTGGCTGTGCCGAGCCT NM_003800 TGCCAAAGAAGTGAGCCATGAAATGGATGGACTTATTTTTCAGCCTACTG NM_030956 TGCTAGGTCAATGCACACAAACATGGCACAGGGTTAGGAAAACAACCCAA NM_003453 GGACCGAAACACCTTGGAAAATATGCTTGTACGGGTTCTTCTAGTAAAAG NM_018136 CCTGTAAGGACCAGAATAGTTTCAAGACTTAAGCCAGATTGGGTTTTGAG NM_000682 GCATCTACCTGATCGCCAAACGCAGCAACCGCAGAGGTCCCAGGGCCAAG NM_181802 GTCAGGACCATTCTGCTCTCCATCCAGAGCCTTCTAGGAGAACCCAACAT XM_058619 ACATTGCCCGTCAGAAGCTTTTAGGTTTGTTCTGTCAGTCAAAACCAAGG NM_016343 CCAAAGCTGGACTGGAGTCCAAGGGCAGTGAGAACTGTAAGGTCCAGTGA NM_018248 GCAAGCGTTCCACCATGAAAACAGTATTGAAGATTGGACCTAACAATGGA NM_000194 GAGCTATTGTAATGACCAGTCAACAGGGGACATAAAAGTAATTGGTGGAG NM_004526 TGGCAAGCACAAGGTACGTGGTGATATCAACGTGCTCTTGTGCGGAGACC NM_002426 CCAAGAACTTCCAAGGAATCGGGCCTAAAATTGATGCAGTCTTCTATTCT NM_002608 CTGTCTCTCTGCTGCTACCTGCGTCTGGTCAGCGCCGAGGGGGACCCCAT AF108138 GGTGCCCGAGGGGTGGTAGTTGGGTTCGAGGCAGAAGGGAGAGGGCTACC NM_002692 CTACGACAAATACCGAATGCCTCTGCATAAACCCTGGCTCTTTTCCAAGA NM_003349 TTCAAGCGTCTTACCTGAAGTCACAAAGCAAACTGAGTGATGAAGGAAGA NM_001067 CTCCTCGGGCAAAATGTGTACGGGCAAAGAAACCTATAAAGTACCTGGAA NM_013282 TGCAAGCACTGCAAGGACGACGTGAACAGACTCTGCCGGGTCTGCGCCTG NM_002356 GGCGGCTGTGGCCTCGTCGCCTTCCAAAGCGAACGGACAGGAGAATGGCC NM_002592 AACGGTGACACTCAGTATGTCTGCAGATGTACCCCTTGTTGTAGAGTATA NM_003113 ACTCCCAGGGAATTTGAAATTGAAGGAGACCGCGGAGCATCCAAGAACTG NM_005292 GCGCAGAAAAAGTTTCCGATCTGGTAGTCTACGGTCACTAAGCAATATAA NM_000022 CTCCCAGCTAACACAGCAGAGGGGCTGCTGAACGTCATTGGCATGGACAA NM_005163 TACAAGGAGCGGCCGCAGGATGTGGACCAACGTGAGGCTCCCCTCAACAA NM_001295 TGTTTCAGGCTCTGAAACTGAACCTCTTTGGGCTGGTATTGCCTTTGTTG NM_005191 AGAGAAGGAGGAATGAGAGATTGAGAAGGGAAAGTGTACGCCCTGTATAA NM_006889 CCTGAAAGATCTGATGAAGCCCAGCGTGTTTTTAAAAGTTCGAAGACATC NM_001846 TGGTGATGTCTGCTACTATGCCAGCCGGAACGACAAGTCCTACTGGCTCT NM_004460 ACCAGAACCACGGCTTATCCGGCCTGTCCACGAACCACTTATACACCCAC NM_032682 CCATCCAGAATGGGTCGGGCGGCAGCAACCACTTACTAGAGTGCGGCGGT NM_006120 CTTCTGTGGCTGCTACCCCACTCCTGGGCCGTCCCTGAAGCTCCTACTCC NM_002120 ATATGTGAGGACGCAGATGTCTGGTAATGAGGTCTCAAGAGCTGTTCTGC NM_006010 TACATCCGGAAGATAAATGAACTGATGCCTAAATATGCCCCCAAGGCAGC NM_005533 TACCCCAAGGACAGCAGGGCCTAGCAGTCTTCACCTCTGAGTCAGGCTAG NM_001560 GTTACTCATTGTTCCAGTCATCGTCGCAGGTGCAATCATAGTACTCCTGC NM_000632 TCCTGATCGTGAGCACAGCTGAGATCTTGTTTAACGATTCCGTGTTCACC NM_004972 GGGATCTAGCTCTTCGAGTGGATCAAATAAGGGATAACATGGCTGGATGA NM_004995 CTCCCAGAGGGTCATTCATGGGCAGCGATGAAGTCTTCACTTACTTCTAC NM_172390 ACCTTTCTCCCGCTGCCTACACCAAGGGCGTTGCCAGCCCGGGCCACTGT NM_005384 CAGAGGTTGTCTCACTCAAGAGACTTATAGCCACACAACCAATCTCTGCT NM_001675 ATTTGATAGAAGAGGTCCGCAAGGCAAGGGGGAAGAAAAGGGTCCCCTAG NM_000960 GCCGTGGGAACGTCGTCCAAAGCAGAAGCCAGCGTCGCCTGCTCCCTCTG NM_000963 CGGACTAGATGATATCAATCCCACAGTACTACTAAAAGAACGTTCGACTG NM_003037 AAACAAATTCCATCACAGTCTATGCTAGTGTGACACTTCCAGAGAGCTGA NM_003121 GCGCGCGCCCTCCGAAACTACGCCAAGACCGGCGAGATCCGCAAGGTCAA NM_007315 CTCGGATAGTGGGCTCTGTAGAATTCGACAGTATGATGAACACAGTATAG NM_006290 GGCAATGCCAAGTGCAACGGCTACTGCAACGAATGCTTTCAGTTCAAGCA NM_007115 CTGGCACATTAGACTCAAGTATGGTCAGCGTATTCACCTGAGTTTTTTAG NM_012452 AGTCCGGCCAAGTCTTCCCAGGATCACGCGATGGAAGCCGGCAGCCCTGT NM_003820 AAGGTGATCGTCTCCGTCCAGCGGAAAAGACAGGAGGCAGAAGGTGAGGC NM_005104 TCCTCTGCACAGCAAGTAGCAGTGTCACGCCTTAGCGCTTCCAGCTCCAG NM_000043 GCTGGAGTCATGACACTAAGTCAAGTTAAAGGCTTTGTTCGAAAGAATGG NM_003326 GAATGGCGGAGAACTGATTCTTATCCATCAAAATCCTGGTGAATTCTGTG NM_005658 GCCTACGTGAAGGACGACACAATGTTCCTCAAGTGCATTGTGGAGACCAG NM_006060 CGCTGCCACAACTACTTGGAAAGCATGGGCCTTCCGGGCACACTGTACCC NM_002371 AGGGTGTCATCCAGGTACGTTCCAGCCGGCCAGCCATGCTCCTCCAGTGA NM_005608 AGAGCAGGTCCCCGTGCGGGCTGAGGAAGCCAGAGACAGTGACACGGAGG NM_005348 TGAACCTATGGGTCGTGGAACAAAAGTTATCCTACACCTGAAAGAAGACC NM_000033 CTCGCGTGTGGTGGCCAACTCGGAGGAGATCGCCTTCTATGGGGGCCATG NM_004915 GAAGAGGTAAAGCAGACAAAACGATTAAAGGGGTTGAGAAAGGACTCCTC NM_005186 GATCAGCGTGAAGGAGTTGCGGACAATCCTCAATAGGATCATCAGCAAAC NM_005166 ATGCGTCTGTTCCAAGGGGTTTCCCTTTCCACTCATCGGAGATTCAGAGG NM_015193 GACACGCAGATCTTCGAGGACCCTCGAGAGTTCCTGAGCCACCTAGAGGA NM_001178 GCAACCGCAAACGGAAAGGCAGCTCCACTGACTACCAAGAAAGCATGGAC NM_004317 GTGAAGCTGCCGCTGTTACCCCATGAGGTGCGGGGGGCAGACAAGGTCAA NM_001187 GCTGGAGGTTGGAGCCTGAAGACGGCACAGCTCTGTGCTTCATCTTCTGA NM_172171 GGATCACCAGAAACTAGAACGTGAGGCTCGGATATGTCGACTTCTGAAAC NM_016280 GGCTGAGGTAGGTCTCCGGCTGGTACGTCTCTGGCTGGACACCCACACCT NM_000743 GGACAGCAGGATTGTTTCTGCAACCCCTGATGGCCAGGGAAGATGCATAA NM_001762 TAAAATTCAAGCAGAACATTCAGAATCAGGTCAGCTTGTGGGTGTGGACC NM_001910 CTGCAAAACGCCATTGGGGCAGCCCCCGTGGATGGAGAATATGCTGTGGA NM_000778 ACCTGCTTGTCTACCTGTCTCCTACCCACCTGTATCTCTTGTTGGGAGAA U53532 ATGAATATCTTGGTAACTCACCTCGACTTGTCATTACGCCTCTAACTGAC NM_001939 CACACACTCCCGAATTGAGCATTTTGCGAGCAGGCTTGCTGAGATGGAAA NM_004091 GGTAGGCAGGGGAATGTTTGAAGACCCCACCAGACCTGGGAAGCAGCAAC NM_001441 AGCTGCAGGGTGCCGTGCCCTTCGTGCACACCAATGTTCCACAGTCCATG NM_000148 TTTGCTGGCGATGGACAGGAGGCTACACCGTGGAAAGACTTTGCCCTGCT NM_001777 CTATACAACCTCCTAGGAAAGCTGTAGAGGAACCCCTTAATGCATTCAAA NM_002049 ATGCGGAAGGATGGTATTCAGACTCGAAACCGCAAGGCATCTGGAAAAGG NM_002068 AAGAAGGGCGCACGATCCCGACGCCTTTTCAGCCACTACACATGTGCCAC NM_005275 CCCGGGCCATACCCGATACTTTCAGACCTACTTTCTTACCCCCTCTGTGA NM_002076 CCGTCTCATGTTCAGCAATCGCGGCAGTGTCAGGACTCGAAGATTTTCCA NM_005288 TTGATAGCGGATTACACCTACCCCTCCATCTATACCTACGCCACCCTCCT NM_002094 GTCGGATTTCTGTCCTTGGTACATTGGATTACCGTTTATTCCATATCTGG NM_005513 AAAGGAAGCATATATAGCAATGGGACAACGCATGTTTGAGGACCTCTTTG NM_004963 GGTAGCCAGCTATAAAAAAGGCACTCTGGAATACTTGCAGCTGAATACCA NM_000182 GATTTGAATTCTGACATGGATAGTATTTTAGCGAGTCTGAAGCTGCCTCC XM_033511 ATACTACCCCTCTGGTTTCCCGGAGTGTTCCACCAGTCAAACTGGAGGAT NM_006825 AGGACTGCTGTGGACAGTTTGGTTGCATACTCGGTCAAAATAGAAACCAA NM_000867 GTACCAGAGTCCAATGAGGCTCCGAAGTTCAACCATTCAGTCTTCATCAA NM_006764 TGCTGCCTTCAAAGCCCGGACCAAGGCTCGAAGCCGTGTGCGGGACAAGC NM_000612 GGAGGCCAAACGTCACCGTCCCCTGATTGCTCTACCCACCCAAGACCCCG NM_006083 GTATGGTATCAAAATGTCTGAAGGGCGGAAAACCAGGCGCTTCAAGGAAA NM_006084 CTGCCCAGCAACGAGTGCGTGGAGCTCTTCAGAACCGCCTACTTCTGCAG XM_045712 ATTAACACCGAACCCCTGTTTGGCACATTGAGAGATGGATGCCATCGGCT NM_000229 ATTTCCACACCCAGCTTCAACTACACAGGCCGTGACTTCCAACGCTTCTT NM_000234 GTGCTCAGGTGGCCTGTTTGTACCGGAAGCAAAGTCAGATTCAGAACCAA NM_025247 TTCAGCCTTTCAGTCCCTCTCTCTCTGCCTGTGGGAATCTGGACACATTT NM_004255 AACTTAGACCAACTTTAAATGAACTGGGAATCTCCACTCCGGAGGAACTG NM_133259 ATCTGTTTCTAAAGCGTTACGCATCTTTGCTGAAGTATGCTGGAGAGCCT NM_000239 GTGCAAAGAGGGTTGTCCGTGATCCACAAGGCATTAGAGCATGGGTGGCA NM_005909 CATGAGAAACAGCAAGATCTCAACATCATGGTTTTAGCAAGCAGCAGCAC NM_002379 CAGGCCCTGACCAGGAAACTGGAAGCTGTGAGTAAGCGGCTGGCCATCCT NM_002396 TGTATGAATGGCCAGAATCTGCATCAAGCCCTCCTGTGATAACAGAATAG NM_139202 TGAGGACCCTCCCAGGTTTCCCACTGCGGAACAGGAGTGACTCTGGCTGC NM_002421 CAAAATGATAGCACATGACTTTCCTGGAATTGGCCACAAAGTTGATGCAG NM_002523 CGTCGATGTGTTCGGAGGGGCCTCCAAGTGGCCCGTGGAGACGTGTGAGG NM_001862 AATACCAGCGTCGTCTGGTTTTGGCTGCACAAAGGCGAGGCCCAGCGATG NM_006981 AACAAGATCACAAGCAGTTTAAAAGACCACCAGAGTAAGGGACAGGCTCT NM_002527 AATAAACTCGTGGGCTGGCGGTGGATACGGATAGACACGTCCTGTGTGTG NM_002557 CATTCCTCTGTCAACTCAGTAACCCCTCAAACAAGTCCTCTTTCTCTAAA NM_014735 CCATGACTCTAGACGGGATTGCCATGGTAAAAGCAAGACACATCCCCTTT NM_032940 AATACGATCCAGACAATGCCCTGAGGCACACAGTGTACCCCAAGCCCGAG NM_002739 TGGAACGATTGGAGATCCCGCCTCCTTTCAGACCCCGCCCGTGTGGCCGC NM_134260 TGGGATTCTCCAAATACTCCATCAGTGTATCCTGTCTTCAGGTGATGCTT NM_003973 GCATGCAGCTCACTGATTTCATCCTCAAGTTTCCGCACAGTGCCCACCAG NM_006642 CATGCTGTTAATCAGCTCAAAGATTTGTTGCGCCAACAAGCAGATAAGGA NM_002640 AAGATTAGGAATGATCGATGCTTTTGACGAAGCCAAGGCAGACTTTTCTG NM_004374 GGCTGATCAAAGAAAGAAGGCATACGCAGATTTCTACAGAAACTACGATG NM_005850 CCGGGTGGGATGCCCCATCCAGGGATGTCTCAGATGCAGCTTGCACACCA NM_000578 GCTGAACAAGGTCGTCACCTCTTCCATCATGGTGCTAGTCTGCACCATCA NM_014251 GGTGTAACTTTGCTGACTTACGAATTGCTACAGCGATGGTTCTACATTGA NM_006841 GCGGCATGTGCTTATTGCCGTTGGCCTGCTCACTTGTATCAACCTGCTGG NM_033262 TGATGGGCCCCCGCATGGTGGATATGAGTTTTCAGAAAGCGCTCCTGTTA NM_014720 AGCTCATGAAACGCAGGAAAGAGGAGCTTGCACAAAGCCAGCATGCTCAG NM_006938 CCTGTACAGCTGGAAACGCTGAGTATTCGAGGAAATAACATTCGGTATTT NM_003107 CCGGGACCTGGATTTTAACTTCGAGCCCGGCTCCGGCTCGCACTTCGAGT NM_012448 CACAGAACCCTGACTCAGTCCTTGACACCGATGGGGACTTCGATCTGGAG NM_006453 CTGCGCTTCTGCGTCACGTGGAACACCAACTCGCGGCACTGCCACGAGGC NM_003315 AAGAAAAAGACTCGCTATGACAGTGGACAGGACCTAGATGAGGAGGGCAT NM_170695 ATACACAGAGTGGTCTTTTCAACACTCCTCCCCCTACTCCACCGGACCTC NM_005077 CCGTTCCTGTAAATTGCTACCCGATGGCTGCACTCTCATAGTGGGAGGGG NM_133502 AGGAGAAGCAGGAGGATGCAGCCATCTGCCCAGTGACAGTGCTCCCTGAG NM_005157 AGGCATGGGGGTCCACACTGCAATGTTTTTGTGGAACAAGCCCTTCAGCG NM_004418 CATCTGTCTGGCATACCTCATGCAGAGTCGCCGTGTGCGGCTGGACGAGG NM_001719 GACGCTGGTCCACTTCATCAACCCGGAAACGGTGCCCAAGCCCTGCTGTG NM_006835 CAAGACAAGAGGGACATGCTTCCCCTTGTCCACCTTTGCAGCCTGTTTCT NM_000610 CCAAACACCCAGAGAAGACTCCCATTCGACAACAGGGACAGCTGCAGCCT NM_012287 CTTGTTACGTTTAGCAAGAATGAATGAAGAGATGCGGGAATCAGAAGGAC NM_003879 TCTGGCTGCAGCACACTCTGAGAAAGAAACTTATCCTCTCCTACACATAA NM_005197 TGCCAGTGCCATGATGCTTTTGAATACTCCCCCTGAGATACAAGCAGGTT NM_001882 GAAAACCCAAATGGAAACAGTATCGGGGAATTCTGTTTGTCTGGTCTTTG NM_001319 CTCAGGTCTACTACTTCGGTCCGTGCGGGAAGTACAACGCCATGGTGCTG NM_001921 GTGCAGCAAGATTGTCATTGACTTTGATTCAATTAACAGCAGACCGAGTC NM_006824 TTTCCTTGAGGGAGATCAGAAACCTCTGGCACAGCGCAAGAAGGCAGGAG NM_003648 TCTGTGAGTATAAGGACATCTTCACACGGCACGACATCCGGGGCTCTGAG NM_004441 CCGCAGTGGCTGCGATGGAAGAAACGTTAATGGACACCAGAACGGCTACT NM_002025 CATACTGCTGGACACTCTGAGCAGAGCACCTTTTCCATCCCAGGACAGGA NM_001530 ATACAAGGCAGCAGAAACCTACTGCAGGGTGAAGAATTACTCAGAGCTTT NM_005531 AAAGTGGGAATACCGGGGAGTTGAGATCTGTAATTCATAGTCACATCAAG NM_000874 GCTATTCACAGGTGCAGTCATAATGCACTACAGTCTGAAACTCCTGAGCT NM_014002 GAACTGAGGTCCAGGCTGCGGACTCTAGCGGAGGTCCTCTCCAGATGCTC NM_000628 GCACCTGAAAGAGTTTTTGGGCCATCCTCATCATAACACACTTCTGTTTT NM_000880 GGAAGGTATGTTTTTATTCCGTGCTGCTCGCAAGTTGAGGCAATTTCTTA NM_001567 TTCAATAACCCTGCCTACTACGTCCTTGAAGGGGTCCCGCACCAGCTGCT NM_001398 TGAGCATGCTGCAGACCCAAGACCTCGTGAAGTCGGTCCAGCCCACGACT NM_005544 GTCTGGCCCGGTGGCTTTCCACAGCTCACCTTCTGTCAGGTGTCCATCCC NM_002249 GAGAAAGCGACTGAGTGACTATGCTCTGATTTTTGGGATGTTTGGAATTG NM_002755 ATACGGAATGGACAGCCGACCTCCCATGGCAATTTTTGAGTTGTTGGATT NM_003954 GAAAGTCCAAATACAGTCTCTTAATGGTGAACACCTGCACATCCGGGAGT NM_002748 CCTGCTTTTGATACCAATTACTCTACTGAGCCTTGTTGGCAATACTCAGA NM_002408 GGGGAGATATTAGGGACCATGAACTCTGTAAAAGTTATAGAAGACTGCAG NM_004927 CAACATCCCCGTCTACAAGGACATCACGCATGGCAACCGGCAGATGACTG NM_004998 GCAGTCTACCAGTTCAGACCGAGTGTCACAGACGCCAGAGAGCCTGGATT NM_003908 GACTCTATTTCCTACAGTGCGAAACTTGTCATTCTAGATGTTCTGTTGCC NM_005009 AGGCTGCCCCAGGAACCATAAGGGGTGACTTCAGCGTCCACATCAGCAGG NM_002542 CAGGTCATCACCACTTTTATGACCTTTCTCGGACCCCATAGGCTGGATCA NM_012383 GCACTGCCTTATACTGGGCTTGCCACGGGGGCCACAAAGATATAGTGGAA NM_005746 TATCTTTACATAGGACGCCAGCAGGGAATTTTGTTACACTGGAGGAAGGA NM_002649 CGAAGTTTGCAGAGACAAAGGATGGACTGTGCAGTTTAATTGGTTTCTAC NM_021127 GGCTCCAGCAGAGCTGGAAGTCGAGTGTGCTACTCAACTCAGGAGATTTG NM_006237 TCCCTGAGCACAAGTACCCGTCGCTGCACTCCAGCTCCGAGGCCATCCGG NM_003479 ATACCGACCTAAGATGCGATTACGCTTCAGAGATACCAATGGGCATTGCT NM_014369 TGATCCTGATGGCCTGTCGAGAGATAGAGAATGGGCGGAAAAGGTGTGAG NM_002828 GTCATTTTGGTTGGCGCTTTTGTTGGCTGGAGACTGTTTTTTCAGCAAAA NM_001469 AAAGACTGGGCTCCTTGGTGGATGAGTTTAAGGAGCTTGTTTACCCACCA NM_001754 GCCCTGGGAGGTGGGAGATCTTTGTATAAAAATTGGAACCCAAACTATAA NM_006918 CCTTTGAGGGGAAGGGACCGCTCAGTTATGTGAAGGAGATGACAGAGGGA NM_004630 GCAGGGCGAGCCCACGGCCACACTGGCACCTGAGCTGACCTTTGATTTCC NM_003105 GGGCTATGAGATACACATGTTTGATAGTGCCATGAATATCACAGCTTACC NM_004509 TCTTGAAGGCCTACTGTCATCCACAAAGCTCCTTTTTTACGGGCATCCCA NM_007237 TTTGTACAAGACATGCGCCTCATCTTCCAGAACCACAGGGCCTCTTACAA NM_003120 CACCCCCACCACGTGCACAGCGAGTTCGAGAGCTTCGCCGAGAACAACTT NM_182692 TGTCAGTTAACTCTGAGAAGTCGTCCTCTTCAGAAAGGCCGGAGCCTCAA NM_001066 CAGGTCAATGTCACCTGCATCGTGAACGTCTGTAGCAGCTCTGACCACAG NM_006708 GACCCTCGAGGATTCGGTCATATTGGAATTGCTGTTCCTGATGTATACAG NM_003387 TCCCTCAGTTCGTCCACGCCCCCGTTACCTTCGCCAGGACGTTCAGGTCC NM_006748 TTGGGGTAGACGAGTCCCTTTTCAGCTATGGCCTTCGAGAGAGCATTGCC NM_001877 GGGAAACAAATCCATTCACTGTATGCCTTCAGGAAATTGGAGTCCTTCTG NM_000878 AGTGGCTCTCTTCGCCCTTCCCCTCATCGTCCTTCAGCCCTGGCGGCCTG NM_005923 ATGACTTAAAATGCTTGAGACTAAGGGGAGGGATGCTGTGCACACTGTGG NM_000941 TGTGGGGATGCACGGAACATGGCCAGGGATGTGCAGAACACCTTCTACGA NM_001242 GGGCCCTGTTCCTCCATCAACGAAGGAAATATAGATCAAACAAAGGAGAA NM_006994 TCTGCAACAACCAATCAGAACCATAAGCTACAGGCACGCACTGAAGCACT NM_001629 TTTCCTCGCTGTGCTCTGGTCTGCGGGGCTACTTTGCAGCCAAGTTCCTG NM_002107 CGGTGCTTTGCAGGAGGCAAGTGAGGCCTATCTGGTTGGCCTTTTTGAAG NM_021603 GCTGTGGGGGCAATAAGAAGCGCAGGCAAATCAATGAAGATGAGCCGTAA NM_003376 AACTTCTGGGCTGTTCTCGCTTCGGAGGAGCCGTGGTCCGCGCGGGGGAA NM_000034 TCCCTTCCCCCAAGTTATCAAATCCAAGGGCGGTGTTGTGGGCATCAAGG NM_005998 CTGTGAGACCTGGGGTGTAAATGGTGAGACGGGTACTTTGGTGGACATGA NM_002156 AAGAGAAGGACCCTGGAATGGGTGCAATGGGTGGAATGGGAGGTGGTATG NM_002168 CCGCGGCGCCACTATGCCGACAAAAGGATCAAGGTGGCGAAGCCCGTGGT NM_000884 TGGAAGGTGGCGTCCATAGCCTCCATTCGTATGAGAAGCGGCTTTTCTGA NM_005566 CGGAATAAAGGATGATGTCTTCCTTAGTGTTCCTTGCATTTTGGGACAGA NM_006636 CTGCAAAAAAGGTGCTGAGGCTTGAAGAGCGAGAAGTGCTGAAGTCTAAA NM_000269 AAGGACCGTCCATTCTTTGCCGGCCTGGTGAAATACATGCACTCAGGGCC NM_002629 CGCCTCAATGAGCGGCACTATGGGGGTCTAACCGGTCTCAATAAAGCAGA NM_000365 TCCTTGTGGGTGGTGCTTCCCTCAAGCCCGAATTCGTGGACATCATCAAT NM_001148 GATGCTAGTTCTTTGGATTCAAAGACCAAATGCCCAGTAAAAACCCGAAG NM_138271 CAAAAGGTACAGTGATTGTACAGCCAGAGCCAGTGCTGAATGAAGACAAA NM_004049 TGCGGAGTTCATAATGAATAACACAGGAGAATGGATAAGGCAAAACGGAG NM_006624 CAAGAAGCTGGCAACACAGCACAAGCAACTGATTTCTCAGACCAAGAAGA NM_004166 TGCCAAACCCAGTGGTCCGGGAGTTCAGGATTGCATGAAAAAGCTGAAGC NM_002989 GCTATCCTGTTCTTGCCCCGCAAGCGCTCTCAGGCAGAGCTATGTGCAGA NM_003542 TGTGCTTAAGGTTTTCTTAGAGAACGTTATTCGAGACGCCGTCACCTATA NM_012073 GGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCA NM_000732 TGCAATACCAGCATCACATGGGTAGAGGGAACGGTGGGAACACTGCTCTC NM_000733 CCAGAAGATGCGAACTTTTATCTCTACCTGAGGGCAAGAGTGTGTGAGAA NM_001781 CACATTCTCAATGCCATCAGACAGCCATGTTTCTTCATGCTCTGAGGACT NM_001809 ACTTCAATTGGCAAGCCCAGGCCCTATTGGCCCTACAAGAGGCAGCAGAA NM_001280 AGTCAGAGTGGTGGCTACAGTGACCGGAGCTCGGGCGGGTCCTACAGAGA NM_007096 GGTTATGTCACAAACATAAACCATCCTTGCTACAGCCTAGAACAGGCAGC NM_001891 CCAAGAACTTCTACTTAACCCCACCCACCAGATCTACCCTGTGACTCAGC NM_001321 CACAACAGTGGCAATTCACGATGAAGAGATCTACTGCAAATCCTGCTACG NM_001908 AGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATCCGCA NM_005517 AAGGGGCATATGTCACTAATAGAATGTCTCCAAAGCTGGATTGATGTGGA NM_001909 CCGCTGATTCAGGGCGAGTACATGATCCCCTGTGAGAAGGTGTCCACCCT NM_014750 CTTGATTCACCAGGTCTAAACTGCAGTAATCCATTTACTCAGCTGGAGAG NM_004944 CAAGGGCCTTCACCAACAGCAAAAAATCTGTCACTCTAAGGAAGAAAACA NM_004089 AGCCAGCGTGGTGGCCATAGACAACAAGATCGAACAGGCCATGGATCTGG NM_004111 GGTGAGACCACCAGCCACCTGATGGGCATGTTCTACCGCACCATTCGCAT NM_006851 TACGGACCAGGAGGGAATTACCCAACTTGGCCATATAAGAGAGGAGCCAC NM_000405 GAAAAAGCCATCCCAGCTCAGTAGCTTTTCCTGGGATAACTGTGATGAAG NM_002110 TCCGAGCTCTGGAGCGTGGATACCGGATGCCTCGCCCAGAGAACTGCCCA NM_005524 CAGTTTGCTTTCCTCATTCCCAACGGGGCCTTCGCGCACAGCGGCCCTGT NM_002136 GTCGTGGAGGTGGTTTCGGTGGGAATGACAACTTCGGTCGTGGAGGAAAC NM_145904 GCCACAGCCCCCTTGCCCTCCGCCTGGGATCTGAGTACATATTGTGGTGA NM_005527 GAGCAGATGTGTAACCCTATCATCACAAAACTCTACCAAGGAGGATGCAC NM_007355 GTGGTGCTGCTGTTTGAAACCGCCCTGCTATCTTCTGGCTTTTCCCTTGA NM_004258 GGTACGTGTCTCCAAAGTGTACTGGACCGAAAATGTGACTGAGCACAGAG NM_002194 ATTTGCCACAGTTGGTGTACCACGTGGAAAATGAGGGTGCTGCTGGGGTG NM_000885 CTTGTCCAAGACTGATAAGAGGCTATTGTACTGCATAAAAGCTGATCCAC NM_002306 TTCTGGGCACGGTGAAGCCCAATGCAAACAGAATTGCTTTAGATTTCCAA NM_002348 AGCCACAGAGGAGTCAGCTGCAAATATTCTCTTCTGTTCTACAGACCTCT NM_005916 AGAGTCTCTGGCTGACTACATCACAGCAGCATACGTGGAGATGAGGCGAG NM_005520 TGATGGGAGGCATGGGCTTGTCAAACCAGTCCAGCTACGGGGGCCCAGCC NM_002397 ACGATGCCATCAGTGTCTGAGGATGTCGACCTGCTTTTGAATCAAAGGAT NM_014791 CCTGGGTTTACAAAAGATTAGTGGAAGACATCCTATCTAGCTGCAAGGTA NM_000918 AACGGGGAACGCACGCTGGATGGTTTTAAGAAATTCCTGGAGAGCGGTGG NM_002627 GGGGGGCTCGCGGCCGGAGCTGATGCCGCATACATTTTCGAAGAGCCCTT NM_006219 AACAAAGATGCCCTTCTGAACTGGCTTAAAGAATACAACTCTGGGGATGA NM_002654 CGGAATCCCCAGACAGCTCGTCAGGCCCACCTGTACCGTGGCATCTTCCC NM_000302 GCTGGACCCTCATGCACCCTGGACGACTCACGCATTACCATGAGGGGCTC NM_002674 GGTCTGCCACTCAATCTGGCTATAAAAGGATATCAAGCACTAAAAGGATC NM_002140 AGATCGGATCATTACCATTACAGGAACACAGGACCAGATACAGAATGCAC NM_002702 TTATTGGAACCCTTCCATGGGTAGTGAACTCAGCTAGTGTGGCGGCCCCA NM_002802 ATATGACTCCAATTCTGGTGGTGAGAGAGAAATTCAGCGAACAATGTTGG NM_005055 CTCCGCCATGAGCATCATGACCGAGATCGGAAACCGCCTGGGGCAGGTGC NM_015004 ATGTCCCCTGCATTGTCACTCTGTGCAAGATTGGCTATCGGCATGTGGTG NM_002970 GTTGGTTTTGCCATGTACTATTTTACCTATGACCCGTGGATTGGCAAGTT NM_005410 AAACCTCCCATCTTTATGTAGCTGACAGGGACTTCGGGCAGAGGAGAACA NM_003034 GTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTTTCAGAAC NM_005628 GGCAGGACTCCTCCAAAATTATGTGGACCGTACGGAGTCGAGAAGCACAG NM_004955 TCCAGCCGTGACTGTTGAGGTCAAGTCCAGCATCGCAGGCAGCAGCACCT NM_031844 CTCAAGGCCGAGCTCATGGAGCGACTCCAGGCTGCGCTGGACGACGAGGA NM_003091 CGATTCCTCAGGGCCACGTTACCACAGACCTGTTTGTTTCTTATGCTGTT NM_004780 GCCCGCAATTTAGAGGGGACATACATGGCAGAAATTTAAGCAATGAGGAG NM_005650 CCGTGCCCTCTCCCCCCCTTGCAGAACAAGACCGCGAAAGGCAGCCTCAG NM_003249 AAGCTGCATCCTGAGACCCGGCGGTTCCGAGGATGCCAGCGCCATGCTGA NM_148968 AGGTGACATGGTCCTGGGACCAGTTGCCCAGCAGAGCTCTTGGCCCCGCT NM_000074 ATTTGAATTGCAACCAGGTGCTTCGGTGTTTGTCAATGTGACTGATCCAA NM_016292 TGGACTTGTTGACGACCCTAGGGCCATGGTGGGCCGCTTGAATGAGCTGC NM_021643 CATCCTTGGTTTTCTACAGATTTTAGCGTCTCGAATTCAGCATATGGTGC BX436497 AAACTGTTTTTTGGCAGTGGAACCCAGCTCTCTGTCTTGGAGGACCTGAA NM_005347 ATTGTTCAACCAATTATCAGCAAACTCTATGGAAGTGCAGGCCCTCCCCC NM_003328 GCTTAGGAAGGAAATGCTACTGAGTGTATGCCAGGATATATGTGAAGGAA NM_007013 CAAACTGGTGAATTGACAGTTGTGCTTGATGGATTGGTGATTGAGCAAGA NM_021089 AGCCGGCGGCGTGAACAATCCTCGAGCAGGAACTCACACCTGGTTCAGCA NM_004310 GGCGACTCTGCTGTGGGGAAAACCTCTCTGTTGGTGCGCTTCACCTCCGA NM_016733 CAGGACTGTCAACGAAACCTGGCACGGCTCTTGCTTCCGGTGTTCAGAAT NM_002818 CTCCAAGGAGACTCATGTAATGGATTACCGGGCCTTGGTGCATGAGCGAG NM_005018 GGAGTATGCCACCATTGTCTTTCCTAGCGGAATGGGCACCTCATCCCCCG NM_002574 CTGTTGGCCGCTCTGTGGATGAGACTTTGAGACTAGTTCAGGCCTTCCAG NM_031966 ATGCCACATCGAAGCATGCTAAGATCAGCACTCTACCACAGCTGAATTCT NM_006854 GCCTCTCATTTTTAGTTAATCACGATTTCTCTCCTCTTGAGATCCTCTGG NM_006332 GCGGAGAGCTCATGGAAGGCGAGTGGGAACTCGGCTGCCTGCCTTTTTTT NM_004619 GCCAAGAACGCCTACATTAAAGATGACACTCTGTTCTTGAAAGTGGCCGT NM_016155 GCCCACAATGACAGGACTTATTTCTTTAAGGACCAGCTGTACTGGCGCTA NM_002659 GAACGCTCACTCTGGGGAAGCTGGTTGCCATGTAAAAGTACTACTGCCCT NM_000485 TATTCAGGGACATCTCGCCCGTCCTGAAGGACCCCGCCTCCTTCCGCGCC NM_006763 TTGGGGAGGACGGCTCCATCTGCGTCTTGTACGAGGAGGCCCCACTGGCC NM_001743 ATCTCTTGGGCAGAATCCCACAGAAGCAGAGTTACAGGACATGATTAATG NM_006191 CCAATGGCCCCATGCGGATAACCAGTGGTCCCTTCGAGCCTGACCTCTAC NM_176783 ACTCAAATCTCTAAGTATTTCTCTGAGCGTGGTGATGCAGTGACTAAAGC NM_002961 GTAACGAATTCTTTGAAGGCTTCCCAGATAAGCAGCCCAGGAAGAAATGA

TABLE 28 Polynucleotide probe sequences for preparation of a large 30mer nucleic acid array GenBank Accession Number Polynucleotide probe of Target gene sequence (5′ to 3′) NM_000246 CAACAGGATTCACGGATCAGCCTGAGATGA NM_005175 TTGGCAGCTTGATCATTGGCTATGCCAGGA NM_006559 GGTGCAAAGATCTCTGTATTGGGAAAGGGC NM_030666 GGTAGCATCCTATTCTTGGGGAGATTTTCT NM_003955 TTCCTGGACCAGTACGATGCCCCGCTTTAA NM_018209 GATGATGGCTGGGACAACCAGAACTGGTAG NM_001165 GTGTCCTATTTGTAGGAGTACAATCAAGGG NM_014670 TTGCTGCCTTTACTACTCAAGGTCAGTCTG NM_144578 ATGCCTGGTGGCCCCCATTCTTACCATTAA NM_144628 GGCAGTGATGGGGCTGACAGTGGCACTTGG NM_032263 GGCGAGGCACTATGATACGGAGAGAAATTG NM_006579 ATGCTGTGAAGCACCTCACTCATGCCCAGA NM_000877 TTCATCTAAACACCAGTTACTGTCACCAGC NM_002266 TACACTTTCCAAGTTCAGGATGGGGCTCCT NM_018462 TTTACACAACACAGGCCACATGGGAAAGGC NM_002444 GGGCCGAGACAAATACAAGACCCTGCGCCA AB032991 CAGAAACATGTCTGAAAGTATGGCAGCTGC NM_004762 AAGAAGGTCTCCTCCACGAAGCGACACTGA NM_000295 GGTCTGCCAGCTTACATTTACCCAAACTGT NM_030674 CACACATCAGCAATCTCTCACCACTTCTTT NM_022743 GAATGCGACGCCAACATCAGAGCATCCTAA NM_003217 GGCTTCGTCCTTGTTGATACTCAACTCATT NM_022366 CTGTATGATGAAACCCTGGAAGATAGGTAG NM_021109 TCCACTGCCTTCCAAAGAAACGATTGAACA NM_014268 TTCAGAAGAACACGAGGGCCACACAGAAGA NM_003352 GAACAAACGGGGGGTCATTCAACAGTTTAG NM_001923 TGGCAGCGGTATGAAGCGAGAGGCCACTGC NM_033503 AAGCAGAGGTACAGATTGCCCGAAAGCTTC NM_178155 AACGGTCAAGTACCCCACATATCCTGAGGC XM_088315 TGTGCGTGGTCTCCAGGTTTCCCTATTACA AK024458 GCTGGGATCCATGGTTTCCTTACTACAATT NM_014397 AGAGACCTGACATCGGATACGTGCACCAGG NM_005969 GATGATGCGGAAATTAACCCCAAGGTGTAA NM_002221 GGGGCTCAATAACCTCGTCGACATCCTGAC NM_013314 CCCATGGTGAATAGATCAACCAAGCCAAAT NM_004844 GCTGACATAAAAATGGTGCAGATTGGCTGA NM_001759 CCTACAGACGTGCGGGATATCGACCTGTGA NM_001987 CAGATGAAATCATGAGTGGCCGAACAGACC NM_002827 GCTTACCTCTGCTACAGGTTCCTGTTCAAC NM_004513 GATGGACCTGTCACGATTGTCATCAGGAGA NM_001237 AAGTATCATGGTGTTTCTCTCCTCAACCCA NM_172164 GAGAATCAGCTGAAACGCGGAGCAGCAGTG NM_000424 TGGCTTCAGTGCAAGCAGTGGCCGAGGGCT AB037771 CCAAGCTCTCTTTTCCAGAGAGCAGTGGCT NM_025113 GACTGTTCAACATGCCTTATGATAACACCG NM_032873 GGACCAACTGGGGGCTTCAACTGGAGAGAG NM_023037 GACTCCAGTGTTTCTGGCACTAGTCTCTGA AF509494 CTTGAGTAAGACAAGTCTGGTGAACGAATG NM_004556 GCGGAATGTGGAGGATGAGACGCCCCAGGA NM_002984 GAGTACGTGTATGACCTGGAACTGAACTGA BC025340 CAGCTGTTGGGGAATTACCGATGCCTTTGA NM_030926 GCTCCTCATGAACGTGAAGAGGGGGACCTA AF331856 ACTATACTGACGTCTCCAACATGAGCCGCT NM_000483 AGGGACTTGTACAGCAAAAGCACAGCAGCC NM_006931 CCATCCTTCCTGCTATCCTACAAAGTGCAG NM_001888 CAAACTCATCTATGATTCCTGGTCATCTGG NM_003804 AGCAGCTTGATTTACGTCAGCCAGAACTAA AB018263 AACTCCACGCTCACTGCCTCGGAGGTCTGA NM_006230 TTCTCGGGCTTCGGGGCAGAGGACGATGAC NM_006475 CAATAACTGAAGTGATCCATGGAGAGCCAA NM_001786 GGGGATTGTGTTTTGTCACTCTAGAAGAGT NM_031942 TGAGATACAAGATGGAATGAGGCTGCAGTC NM_001640 AGGGCATGGAGTATTACCGTGCCCTCAAGA NM_002483 GTGGCCACCGTCGGCATCACGATTGGAGTG NM_003915 GCTCCGATTATGACAGTGACGGGTCACATG NM_018842 CCAGTGAGAAGCTTCAGTGGAGAGGCCTAA NM_147180 TATCCTTTGAGGAATTCAGTGCTGTGGTCA NM_004924 ACGGCCTTGTATGGCGAGAGCGACCTGTGA NM_002276 ATCACTACAACAATTTGTCTGCCTCCAAGG NM_002695 GTGAGACGGCTGGCAGGTACATCACCTACC NM_003480 CCTCCCTGTGAAAATGTGGATTTGCAGAGA NM_002023 CTCCAAGGCAATAGGATCAATGAGTTCTCC NM_006216 GTGTTATTCATGGGGCAGATAAACAAACCC NM_021813 TAAGTGTACAACTGACGAACAGCCCAGGAA NM_006565 GAAGACCAGAATACAGGTGCAATTGAGAAC NM_005537 CTTTCGGGCGCGGATTTATAGCAGTAGCAG NM_004235 CCTCGCCTTACACATGAAGAGGCATTTTTA NM_006235 GCGCTTAACCACACTCTCTCTGTGGAAGGC NM_016269 TGCATCAGGTACAGGTCCAAGAATGACAGC NM_006164 TTCTCCTAGTGAATACTCCCTGCAGCAAAC NM_003222 CCAGCTGATTCTAACAAAACCCTGGAGAAA NM_000700 GCCAAGCCATCCTGGATGAAACCAAAGGAG NM_019846 GAAACACGAAACATACGGCCATAAAACTCC NM_032738 AACAGCATCTGTTGTGGCTATCACAGTCCA BC019046 TACAGGAACATGATCGGACAGGGGGCCTAG NM_016732 ACCGGGACGACTTCTACGACAGGCTCTTCG NM_002189 GACTTGGAAAACTGCTCTCACCACCTATGA NM_004827 TGGGGCTTGTGGAAGAATCACGTGGCCTTG NM_001830 CAGGACCCCGAATCCATCATGTTTAATTAG NM_020944 GGACAGGGCCTATGTTTGGACCAAAGGAAG NM_017784 TGGAAGCCCAAATATTTTATCCAGGAGGGC NM_002933 CATATGTGCCAGTCCACTTTGATGCTTCTG NM_022829 TTGGCCAATGACACATTTCGGACCCTCTGA NM_006399 AACCTCATGTCAGCTCCCCGCGCTTCCAGC NM_002893 GAAGAGTCAGATGTCACGACATCCGAACTG NM_003339 CCTGAGATTGCTCGGATCTACAAAACAGAT NM_005277 TCCAAAGAGCGGCTCAATGCATACACATAA NM_006820 TTCTCATCCTCTCTGCACTGAGGCAGATGC NM_024728 CATCTTCAAGGATCAGCAAGGGTATTACAC NM_025263 CATCCAGGCGTCAATGGACCTCCTCTGTGA BC046632 GTGAACCTGAGCGACTCGGACAAGCAGTGA NM_024713 CCATCTTACTTTGGTTCCAGGATATACTGG NM_014365 CAGGACAGCCAGGAAGTCACCTGTACCTGA NM_002947 CCCTCAGTTTTATCCTTTAGGGATTGTGCA AK092000 CAGTGTACTGAACATACTGTATACCTCGTG NM_022436 CCAGCTCTTGTCATCCTAGGAATAGTTGTT NM_002967 ATCCCACACGGTGGCATGCAGGGCGGGTTT BX647445 CATAAGATTCCAGCTCCTTCAGGTGTTTGA BC022095 GTCTTGCGAGGACAGCCTCATAGAGAATGA NM_006808 CACATTTGGGGCAAGTACACTCGTTCGTAG NM_031305 CGAGAGAGGAAACACAATATGGATTCAGTG NM_014792 GTTTTCAGGCTGTATCCTTCTACCTCCTGA NM_006304 CAGTTACGAGCTGAACTAGAGAAACATGGT NM_014686 AGTGTGGGCCGCAACCAACGACTGCAGTGC AB029034 AGAGACTCGGCCGTATCCTGAAAATCCACA BQ722784 ACCCCAGATGGTGAAACGGCCCAAGCCAAA NM_198243 TAATTACGGAGCAGACACGAACACACGGAA NM_016570 CGTTTCAGACTTGGATCCTATAAACCTGTC BC001077 CGCGGTAGACGAGCGGATGCTGCGCTTTCT NM_138379 GAAGACGAAGACGGCCTTTTTACCCTCTAA NM_024319 TCTCGCAGGTGGCATGACAGAGGCTCTGAG NM_015670 GAGCTGTGTCACTGCAAACTCACTGTGTGA NM_015436 CAAGCTTTATACTTGCCGCTTGTGTCATGA NM_001240 CTCCTCGAGATCTGGCAATACAGACAAACC NM_001261 AACCAGACGGAGTTTGAGCGCGTCTTCTGA NM_003095 GCTTTGTCTGGACATCTGGGTGAAGTTTTA NM_021102 CGTCTGGAGCTCCGGAGATGACAAGGAGCA NM_003133 ACAGTCAACTAATGCGACTTATGGTAGCCA NM_006819 ATGGATGTGGGTCTGATTGCAATTCGGTGA NM_032966 TGTCGCGGCTCCTGACGAAGCTGGGCTGTA NM_006284 TGCCCTCAGCGAGTATGGCATCAATGTGAA NM_005648 GCTGATGGCTGCGAACTTCTTAGATTGTTA NM_003199 AAATGGACCAACTTCTTTGGCAAGTGGACA NM_003299 GAACATTGACCCTGATGCAAAGGTGGAAGA NM_006758 GCGTGACAGGAGGCGGTCGAGAGATCGTGA NM_194259 GAGAAAAGGGTCCGAGCACAAGCCAAGAAG NM_003366 CAGCAAGTGGAAATTTGGGACATACACCTT NM_006004 CGTGGCCCACAAACTCTTTAACAACTTGAA NM_003374 CACGCGCTTCGGAATAGCAGCCAAGTATCA NM_007048 TGACAGGTGGAAGTACCTGTGTTATTTCCA NM_006761 ACGGTGAAGAGCAGAATAAAGAAGCGCTGC NM_005781 AAGTGCTGGAGATGTTCGACTGGAACCTGG NM_005243 AGTACTCAGCCGGCAGCATAATGAAAAGTG NM_003902 GATCCAGCCAGTATAGAACTAGCTCTGTAG NM_006769 TGAATTCACTTCAGAGCAATCCACTACTGC NM_004689 AACCGCAGTAACATGAGTCCCCACGGCCTC NM_006875 TTGGCCTGGTCCTTGCTACCCTAAGCCTGG NM_002953 CACGTACTCCGCACTCAACAGCTCCAAGCC NM_004965 CAAAAGTGGAAGCGAAGCCGAAAAAGGCAG NM_000592 TGAGGCTGCTCTGGGGGCTGATCTGGGCAT NM_178014 TGAACGACCTCGTCTCTGAGTATCAGCAGT NM_005742 GCTTGATGACTTAGGGAAAGATGAGTTGTG NM_001901 AATCGCTGTACTACAGGAAGATGTACGGAG NM_004907 AGCGTCATCCGAAGTCGCCGATCGCCTGCA NM_003746 ACCGAAAGGCCGTGATCAAAAATGCGGACA NM_001255 TGGCGCTGTTTTGAGTTGGACCCTGCGCGG NM_002417 CTTTGGTGATTCCATTAATGAGAGTGAGGG NM_006209 TATGCTGCGGAAACTCGTCAGGACAAAATG NM_002162 ACGTCTATGCAGCCGACAGAAGCAATGGGG NM_000587 GCATCTCTGTCACCAGCATAAGGCCTTGTG NM_031243 GGTGGAGGAAACTATGGTCCAGGAGGCAGT NM_003017 CTCGTAGTCGATCTAGGTCAAATGAAAGGA NM_004994 CTACGTGACCTATGACATCCTGCAGTGCCC NM_002966 CTTCTTTTCCCTAATTGCGGGCCTCACCAT NM_001345 CCCCCCGCTCCACCAATTTCTTTGGCTTCT NM_002497 GGCTCAAGCCCTGTCAGATATTGAGAAAAA NM_000545 TGAGTCCGGGCTTCACACGCCGGCATCTCA NM_006184 TTCTCGAGCGGCTCCCTGAGGTTGAGGTGC NM_000598 TGTGGATAAGTATGGGCAGCCTCTCCCAGG NM_006152 CTCCGACACAATGGGCCACCACCAGTGTGA NM_006274 TCAGCCAAGATGAAGCGCCGCAGCAGTTAA NM_002105 TGTACACCGGCTGCTGCGGAAGGGCCACTA NM_001428 TCAATGTCATCAATGGCGGTTCTCATGCTG NM_002415 AACTATTACGACATGAACGCGGCCAATGTG NM_003234 GGTGACGTTTGGGACATTGACAATGAGTTT NM_001728 AAGAACGTCCGCCAGAGGAACTCTTCCTGA NM_002460 CAGATCTATCCGCCATTCCTCTATTCAAGA NM_003403 AACATCTGCACACCCACGGTCCCAGAGTCC NM_001344 GTTTGCCTGAGAATACAGATCAACCCACAG NM_002648 GATAGGCCAACCTTCGAAGAAATCCAGAAC NM_006585 GCTATCAAACTCGCTACTAATGCTGCAGTC NM_001826 ACGAGGAGTTTGAGTATCGACATGTCATGC NM_002466 CACACATCTCGGACCCTCATCTTGTCCTGA NM_005582 CTGTGGGATTACAGCCATAGGCATTTTCTT NM_001831 GCAGGAATACCGCAAAAAGCACCGGGAGGA NM_000038 AGAGAGGCAGGCGTGAAATCCGAGTCCTTC NM_007295 TTGCAAGGTCTTACTCTGTTGTCCCAGCTG NM_001226 CGCAGGTTTTCAGATCTAGGATTTGAAGTG NM_033357 TGGATGCAGGTACAGTAGAACCCAAAAGAG NM_005190 GAAGTCAGAACTCTAGCTACAGCCAATCTT NM_001795 GACTGGGGACCCAGGTTTAAGATGCTGGCT NM_001848 AGACGATAACAACGACATTGCACCCCGAGG NM_004380 CAGCCGTTTACCATGAGATCCTTATTGGAT NM_005215 CCAATGTGTATGAACAGGATGATCTGAGTG NM_004948 TGGAGTTTCTAGATCACCTGGAACCCAAAT NM_001397 TGCTGTCGGCGCTGGGGATGTCGACGTACA NM_004448 CATTGACGAGACAGAGTACCATGCAGATGG NM_001982 TTCCCCAAGGCTAATGCCCAGAGAACGTAA NM_006137 ACGAGGACATGTCGCACAGCCGCTGCAACA NM_005245 AGAGGTGACGATCCCGCCCCTGGATTCCCA NM_004119 TCTCCGCAGGCTCAGGTCGAAGATTCGTAG NM_182925 GATAGAGAGCAGGCATAGACAAGAAAGCGG NM_000629 CAGTTCCCAAACTAGCCAAGATTCAGGAAA NM_001552 TGTGGACCGGAAGACGGGGGTGAAGCTTCC NM_000572 GGCTACGGCGCTGTCATCGATTTCTTCCCT NM_000640 GCCAAACACCTACCCAAAAATGATTCCAGA NM_000564 CCACTAACTATGAGGTCCTCTGCATTTTCA NM_176786 CTCAGCAAGGCTCGGTCCTGGACATTCTAG NM_000213 ACTAGGCCTGGCCGGAGATGTGGCTGAACG NM_001967 GACCCAAGCACTAGTATTGGCCCCCACCAG NM_004933 TGTATGGGCACCCGTGCGGGTTGGAGTACG NM_000224 CACCAACTACCGGTCCCTGGGCTCTGTCCA NM_145110 CCAGCATGCCCCAGTCCAAAGGAAAATCCA NM_002758 CTACATACCCAGAGCTAATGCAACATCCAT NM_002412 AAGCCAGGCTTGGGAGGGAGCTCAGGTCTG NM_004530 AGCATCAAATCCGACTGGCTAGGCTGCTGA NM_002422 CTTTCCAGGGATTGACTCAAAGATTGATGC BC063294 GAGCTTTTCCTTGCAGGAGCGTCAGTTGCG NM_004557 CCTCCAAGAAATGCCCATAAACCAAGGAGG NM_002514 CACACCAACTGTCCTAAGAACAATGAGGCC NM_000300 CACTGCAGAGGGAGCACCCCTCGTTGCTGA NM_001276 GGCCAGGATCTGCGCTTCCCTCTCACCAAT NM_000535 GCCAACCTGGGTGTCATTTCTCAGAACTGA NM_015869 GTGCAGCTACTGCAGGTGATCAAGAAGACG NM_002805 TGACACCCAATTGCCGGGTGGCTCTAAGGA NM_000314 CCACTGACTCTGATCCAGAGAATGAACCTT NM_002868 CAAAGAGTGAACCCCAGAATCTGGGAGGTG NM_002901 GCTACCAATTACGGGGAAGATCTCACAAAA NM_003821 CCGGAAATACTTGTGGTTTCTAGATCACCA NM_005617 ATCCCCTCTGACAGCACTCGCAGGAAGGGG NM_014624 TTGATCTACAATGAAGCCCTCAAGGGCTGA XM_044622 GATTGAAGGACCTAGTGTGAGCATAATGGA NM_000602 GGAACAGTCCTTTTCATGGGCCAAGTGATG NM_003012 TGCCCCACCTTTCAGTCCGTGTTTAAGTGA AF311912 ATCACCTCGGTGAAGCGGTGGCAGAAGGGG NM_139276 ACCTCGGAGTGCGCTACCTCCCCCATGTGA NM_003220 AGCCACACGGACAACAACGCCAAAAGCAGT NM_003225 ATCCTAATACCATCGACGTCCCTCCAGAAG NM_003842 AAGAATCAGGTACAAAGCACAGTGGGGAAG NM_000546 CTCCCGCCATAAAAAACTCATGTTCAAGAC NM_138764 GGTCTATAATGCGTTTTCCTTACGTGTCTG NM_001328 GATAGAGACCACGCCAGTGACCAGTTGTAG NM_058197 GGAGTTTTCAGAAGGGGTTTGTAATCACAG NM_000594 CCCAGGGACCTCTCTCTAATCAGCCCTCTG NM_003810 CAGTTTTTTCGGGGCCTTTTTAGTTGGCTA NM_002609 AGGTTGCTGACGAGGGCCCACTGGAGGGTT NM_001069 CACGGCCGACGAACAAGGGGAGTTCGAGGA NM_003005 ACAAACGCTGCATTTGACCCGAGTCCTTAA NM_002985 AAAGAACCGCCAAGTGTGTGCCAACCCAGA NM_000964 GCATATGTTCGGGGATTTGGTGTGCAGTTG NM_024408 CACATGTCTGAGCCACCACACAACAACATG NM_001465 GAGAGAAACCTAAAGTCTCTGACTCAGACA NM_001618 GACCGGGATTTCATCTGGTGTGATAGACAC NM_004322 TCCAGTCCTGGTGGGATCGGAACTTGGGCA NM_021960 TAGTTAAACAAAGAGGCTGGGATGGGTTTG NM_004383 TGAGCACATCAAAACCCACGAGCTGCACCT NM_015583 TGGAGGGAGGTTTTCAGCCCTGGTATATGA XM_373407 TGTCGGGGAGTACCTTCAACTGGCCCTACG NM_016734 GCTCCCCCTACTATTATAGCGCTGCCGCCC NM_000808 GCCACATATGTCAACCGGGAGTCAGCTATC NM_002964 GGCTGGCAGCCCACAAAAAAAGCCATGAAG NM_002965 AGAAGATGCACGAGGGTGACGAGGGCCCTG NM_001250 AGAGAGTCGCATCTCAGTGCAGGAGAGACA NM_003407 GACTCCCCATCTTCAATCGCATCTCTGTTT NM_003674 GAGGGCCAGAGCAAGCGCTGTAAACCCTGA NM_078467 CTCCAAACGCCGGCTGATCTTCTCCAAGAG NM_006145 ATCAAGAACCGTACTTGAGCAGGTTCTTCC NM_000122 CACCCGCTCTTCAAGCGCTTTAGGAAATGA NM_006712 ACCCTTCGAGGAACTGGAGTCCCAGAGAGG NM_000175 TTGCCCTGTCTACTAACACAACCAAAGTGA NM_000162 ATGCTGGACGACAGAGCCAGGATGGAGGCC NM_000852 CTCCCCATCAATGGCAACGGGAAACAGTGA NM_005526 CCCAAAGCCAAGGACCCCACTGTCTCCTAG NM_001540 GCAAAATCCGATGAGACTGCCGCCAAGTAA NM_002432 AAACTGGTGTGTGGAAGTCACAGCTTCATC NM_004146 AAGGCGGCAGAGTTGGCCAAAGGCCAGGGA NM_002505 GTCCAGACCCTCCAGGTAGTCCAAGGGCAG NM_002511 CACAGCATGAAGCAGGAAATGGCAATGTGA NM_006170 GCCTTCTCTACTGTGCATACCCATGAAATT NM_002910 AAAGGCTGCTTCCACGTGCCGCGGTGCCTA NM_005281 TTCCGATCCCGCTCCCCCAGTGATGTCTAG NM_005981 CCTAGAGCCAACCCCAGTGCCTTTCTATGA NM_003410 AAAGTGGATGGCACTTGCCCTGAGGTCATC NM_007146 TGCCTTTCTTGCCCCAAGCTTTGCCTACAT NM_002419 TTGATCCCTGGAGCTTTGTGTCAGCTGGGC NM_001197 TGAGGTTCTGGAGATCCCCGAACCCCGGGT NM_000418 CTCCGTGGGACCCACATACATGAGGGTCTC NM_006254 CAAGAGGCTGGGAATGACGGGAAACATCAA NM_002166 CACGGATATCAGCATCCTGTCCTTGCAGGC NM_033306 CCACCATAGAACGACTGTCCATGACAAGAT NM_020250 ACAGGTGTCTGTATTGCTCTACCTACCTAA NM_000249 CCTGGCTCCATTCCAAACTCCTGGAAGTGG NM_002228 TGATAATCCAGTCCAGCAACGGGCACATCA NM_001654 CTACTCAGCGCAGCCCGCCTTGTGCCTTAG NM_004047 TTGGGGTCATCGTCGCAATTCTTCAGACCT NM_000729 AGTGCCGAGGAGTATGAGTACCCCTCCTAG NM_006273 ACTGTCCCCGGGAAGCTGTAATCTTCAAGA NM_004073 GCTTGTACTTACCTCGCTTCCCACCTTCGG NM_006268 TCTCACCCCGTCCATGTCTGAGCCCCCTGA NM_002104 AGCAACCTTGTCCCGCCTCATACAAATTAA AK127132 AGTGGGTAAAGACCATACGTTGGAGGATGA NM_004422 TGGCCATGGGCAATCCCAGCGAGTTCTTTG NM_006014 TGCCGAGCCCCACCAAAGGGTGGTTGGGAA NM_003824 GTGACCTCCAGAACAGGAGTGGGGCCATGT NM_002055 GAGAGGTCATTAAGGAGTCCAAGCAGGAGC NM_005313 AGCTACAAACCCCCCTGTAATTCAAGAAGA NM_001513 CCAGATACACCCACTGAGCTGAGGGCCTAG NM_003883 GCCAAGACCGTGGCCTATTTCTACGACCCC NM_005339 ACCCATTTAATCCCCCTAAGGTCCGGTTTA NM_003549 AGGGCCCCCTTCAAAAAGCCTGCTGGAGAC NM_004763 CTCTGAAGACCACAGATGCAAGCAATGAGG NM_002301 GCGGAATGGTGTCTCAGATGTTGTGAAAAT NM_004993 CTGACATACGAGCTCCATGTGATTTTTGCT NM_002790 CCTGGCCAGAATTTCCACATGTTCACAAAG NM_002971 CGGTTTAGAGGTCGATGTGGCAGAATATAA NM_003769 CACTACTTCTCTCCTTTCAGGCCCTACTGA NM_005835 CCACCAGGAAAGGTCCAGATTTCTGTTCAT NM_181314 CCCACGTCTGGCCTTCTGTCCACTGTGCTG NM_003262 ATCGATCCCAGCACAGTAGTGGAAATGGAA NM_006497 GGGACCATCGACCGTTTCTCTCCCACCTAG NM_007117 CTGAAAAACGCCAGCATCCGGGCAAGAGGG NM_006759 TCTGGAAACCTTCGCATCTTGGACCACTGA NM_014232 ATCTTGGGAGTGATTTGCGCCATCATCCTC NM_006299 AGCTTTAATCGACACTGCAACCTCATTCGC NM_000072 CAGTGTTGGTGTGGTGATGTTTGTTGCTTT NM_002211 CCAAACTACGGACGTAAAGCTGGTCTCTAA NM_004242 AGGAAGGTACTGCACCATCTGAAAATGGTG NM_005589 GCTGTTGTCATGCCTACCATGGGCCGTTAG NM_022067 TCCAGTCCCTTTCTGATGCTCTGTCAGACA NM_001752 AGTCCGGATCTCACTTGGCGGCAAGGGAGA NM_001793 TGTTCGACTATGAGGGCAGCGGCTCCGACG NM_003159 GACATACCATGAGAATGCGGCACTGACGGG NM_156039 CCCAGGCGATCTGCATACTTTAAGGACCAG NM_004941 AGAATATCTCGAGCTTTCCGACGGCGCTGA NM_021071 CATCTCTCTCCTTTTTGACCAGTGTCATCA NM_005665 AACAGAAGACAGTGTGCTGGAGACCAGAGA NM_004475 ATCAAGAAGGCCACTGGTGTGCAGGTGTGA NM_002133 ACAGTTGCTGTAGGGCTTTATGCCATGTGA NM_004125 GGCTGGCGTGGAGAGGATCAAGGTCTCTCA NM_002102 GGCTCGTGTTATTTTTGAGGTGATGCTTGT NM_005318 TCCAGTGCCAAGAGGGCCGGCAAGAAGAAG NM_002108 CAACAGCCTTTTCACTGCAATTTCTGCACA NM_006644 CCCCTTCACCTGAACTTACCTCAGAAGAAA NM_181430 GCCAGCTCAGACTGGAGTTGCCTCAGTTGA NM_014780 AGATTCGCTCCCGGGGTGTGCCCTATGCCT NM_000917 GGAAAATTGACCACAGCACAGTACAGAGTA NM_000869 CCCACCTCCTGCATGTGTCTCTTGCCTCTG NM_006218 CATGGTGGCTGGACAACAAAAATGGATTGG NM_005084 GGGACCAACATTAACACAACCAATCAACAC NM_002890 CGCTCCTCCAACTAACCAGTGGTATCACGG NM_134269 GAAGGGGCTGGTAAAAACCAAAAAGTCCTA NM_003242 GAAGACGGCTCCCTAAACACTACCAAATAG NM_003451 AATGCACAAGCGAATCCACAATGGCCAGAA NM_019841 ACTGAACCTTAGTGAGGGGGATGGAGAGGA NM_000416 GCTGCTTTACTACTCTTTCTAGTGCTTAGC NM_003177 GTCAGCGGGTGGAATAATCTCAAGAATCAA NM_000277 CCAGCAGCTTAAGATTTTGGCTGATTCCAT NM_053056 TGATCAAGTGTGACCCAGACTGCCTCCGGG NM_000873 GTGTTGCTGTCCCTGTTCGTGACATCTGTC NM_001092 AGGTTCTGGAGGACGAAGATGTGTTTCTCC NM_004454 CCCACTTTGAAGACAGCCCCGCTTACCTCC NM_005225 CTCATCCCTCACCACAGATCCCAGCCAGTC NM_001760 CCTACAGATGTCACAGCCATACACCTGTAG NM_004064 GACGGTTCCCCAAATGCCGGTTCTGTGGAG NM_000075 CTACATAAGGATGAAGGTAATCCGGAGTGA L27560 TCACTCCTGAGAGGGCTCCGGCCCAGAATG NM_002467 CTTGTTGCGGAAACGACGAGAACAGTTGAA NM_001175 CTGTCGATTAAGAAGGAGTGGACAGAATGA AB007921 GGTGCCTGGGATTTTGACTGGGAGATATAG NM_000724 TAAATACATTATTCCTGGGGGTTCGGCAGA NM_002987 TGCTCCAGGGATGCCATCGTTTTTGTAACT NM_001803 CTTCGTGGCCAATGCCATAATCCACCTCTT NM_014376 AGACCAGTGCTCACTATGAAGAGAACAAGT NM_182908 TTGCGGTGGCAGGCTACTCCACTCGGCTCT NM_004434 ACAAGCATCATGCAGTGGCGCGTCATTTAG NM_014210 GCTCACAGCTACAAGGGAAAGAAAAGATGA NM_013451 CAGCCCAACATTTCCAGATACTACCTGCGT NM_003088 TTCGAGTTCTGCGACTATAACAAGGTGGCC NM_000156 ATCATGTTTGAGGAGACGCAGGTGCCCGCG NM_002048 TGAGGACTACGATGACGAGCAGCGCACCGG NM_002051 TGGACCACACCACCCCTCCAGCATGGTCAC NM_000169 ATCCCACAGGCACTGTTTTGCTTCAGCTAG BM722299 GTGGTTCACAACGACAGGCTACTGAGCACC NM_002224 CAGGCAACGCCTAGGCTTTGTGGATGTCCA NM_005335 CTTCCCTGCAAATTATGTCAAGCTTCTGGA NM_002167 CGGAACTTGTCATCTCCAACGACAAAAGGA NM_004633 TGGATGCACAGACGGTGCAAACACAGAACT NM_015187 TACTATCGCCTTCGCAGTCTGCACCCCGCC NM_015196 AGAGACTCGAGTTACTGTGGGAATGTGTGA NM_005556 GAAGGCTTATTCCATCCGGACCGCATCCGC NM_005356 CCCATAGTCCGACTGGATGGGAAGGGCAGG NM_005933 ACTGGGGCAAGAACGGAGTTGCTTCTATAA NM_005098 GACTGGAACTCACTTGATGGGATTATTCGT U50748 GCCTCAATTCCAAACTTGTTCTACTCAGAC AB033114 TAGGAGAAGCACTGTTGTTTTCCACACAGT NM_002499 CCCACCTGGAAGGACTAATGAAGGACCTAA NM_004289 CTTGATAGTACCCAAAGAACTGGTGGCCTC NM_005654 TTCAACTGGCCTTACATGTCCATCCAGTGC NM_020992 TATGAAGTGGTCACTGTGTTCCCCAAGTGA NM_003311 TGAAATCCCCCGACGAGGTGCTACGCGAGG NM_002661 CAGTGTTAATGAGAACCACTCCAGCTGTAC NM_015568 AAGGTGCATGGCTGTTGCCGTATCTCCTAG NM_006115 GTGGGGACAGAACCTTCTATGACCCGGAGC NM_080588 TCCAGACGGCAGAGCAGTACCAGTTCCTGC NM_021038 CGGCTGTCAAATCACTGAAGCGACCCCTCG NM_006498 GCGTAAGGGGCGGGTTCAACATGTCCTCTT NM_014904 AGGGTAATGGAAGAAACGCCCAGTATTCTC NM_002972 TCTCGTTACCGACCACTAGGGGTGGCAGGG NM_006142 TGGAGACTGAGCTCCAGGGCGTGTGCGACA NM_003569 AGTCTCATCATATGGGGATTGAACCACTGA NM_015055 ACCCTCACCTGATCACTAACTGGGGACCTG NM_015173 ACCTTAGAACTGGAGCGGTCGGCCCTGCTG NM_016021 GCATTGGCAGCTCTTATATTCCGACGAATA NM_005573 GAGGAGGTTGCTCAAAGAAGTACAGTCTTT NM_031407 TCCCCTTTCCATGCCGTCCATGATCCCCAC NM_004665 GACCAGCAATTCAGCAATAACTTACCTGCT NM_001783 AGGAGGGCAACGAGTCATACCAGCAGTCCT NM_000626 ACAGAGCTGCGAGTCATGGGATTCAGCACC NM_006762 CAGATTGATCAAGTGCATGAACTCGGTGGA NM_002838 CACCATCACAGCGAACACCTCAGATGCCTA NM_173216 CTGCCTGGCTTCCGGACCATTCACTGCTAA NM_002163 GCCTCACACCAGAGATCATTTTTCAGAGAA NM_002339 GGAAGTATGAGAAGGTGCTTGTGGAAGGGG NM_152866 CCTCACCAATAGAAAATGACAGCTCTCCTT NM_006495 CTCTATTCCTCCCAACTCTGATCAAGATCT NM_005246 ACCTGAAAATCGCCCTAAGTTCAGTGAACT NM_000698 AGCCAGTGGTTCGCCGGCACTGACGACTAC NM_004271 CTGAAAAACGGTCCACCGTGGCCTGTGCCA NM_001715 GATGAGCAACCCCGAGGTCATCCGCAACCT NM_003254 AACTGCAGAGTGGCACTCATTGCTTGTGGA AK090461 TCCCGACGGTGGGTTTGTTCTACTGGGGCC NM_004071 CTCTCAGAGAAGCCTTAAAGCATCCTTTCT NM_000757 CGTTCCTTTGACTGACACAGGCCATGAGAG NM_020548 TCTGCCAATCCGGGCACTGGGACAGAGGCT NM_005232 GAGGCTGGTCTAATTTTCCTTCCCGGGAGC NM_002017 ATCAATCAGCCAGTGAGGGTCAACGTCAAG NM_000206 CCATGTTACACCCTAAAGCCTGAAACCTGA NM_004559 GCTGAGAATTCGTCCGCTCCCGAGGCTGAG NM_021103 ACGCAGGAGAAGAACACCCTGCCGACCAAA NM_138933 GCAGTCCATCATTTTGCAAACTTTGCTGGA NM_001614 TGGAAGAAGAGATCGCCGCGCTGGTCATTG NM_005919 AAGACCTTCCCCTATCCCTTGCTCCTCGCC NM_000026 TCTTTCACTGGTCGTGCCTCCCAGCAGGTG NM_000687 CCCTTCAAGCCGGATCACTACCGCTACTGA NM_001621 CCTGATTTGACATCCAGTGGATTCCTGTAA NM_001647 TTGGCAAGAAACCCTAATCTCCCTCCAGAA NM_001664 CAAGCTAGACGTGGGAAGAAAAAATCTGGT NM_152862 ATCACGGGGAAGACGTTTTCATCCCGCTAA NM_005171 TCAGACTAGCAGCGGACAGTACATTGCCAT NM_001519 GTGTCATACCACGCCGACGAGGAGGCTGAC NM_000900 GCCATGGTTTATGGATACAATGCTGCCTAT NM_001746 AGAAGATGGTGGCACTGTCAGTCAAGAGGA NM_004347 ACCATAGAACGAGCAACCTTGACAAGAGAT NM_005201 CGTTCCTCCAGCGTAGACTACATTTTGTGA NM_000560 GACAAAACCAGCCAGACCATAGGGCTATGA NM_004356 AGGAGGACTGCCACCAGAAGATCGATGACC NM_001769 GCTATCCGCAGGAACCGCGAGATGGTCTAG NM_001827 GAGTCTAGGCTGGGTTCATTACATGATTCA NM_000397 TCTCCAACTCTGAGTCTGGCCCTCGGGGAG NM_004728 GAAGCGGAGTTTCAGTAAAGCATTTGGTCA NM_021907 ACAAGGTACGAGGAGAAACCTCCGCAATGA NM_006169 AAGGACTTTTCTCCCTGGTGGCGAGGAAGC NM_004416 TGGCAGGGATGACCGGGATACTGCTGTGCG NM_001948 CTTACGTCTCTGCTTCGCTCAGCGATGCAA NM_001951 CCCCGGCAGATGACTACAACTTTAATTTAG NM_001961 TCCTGCCCGGAGACCCCTTCGACAACAGCA NM_001412 CATACGGCGAGCTTCCAGAGCATGCTAAAA NM_003752 AAACGAGGGCTACATGCGCCGCGGTGGCTA NM_001436 ATGCCGTGGTCGTGGGAGTGTACAGGCCAC NM_005252 AGCTGCACTGCTTACACGTCTTCCTTCGTC NM_000146 TTCGAAAGGCTCACTCTCAAGCACGACTAA NM_012197 ACCGGGGTTCAAGGGAAAGAGACTTGCTGA NM_000435 GCCGGAAGTTACCCCCAAGAGGCAAGTGTT NM_005890 GACGATGTTTCTTGCCTCTCTCCCCAGAAC NM_002065 ATGAAACCGGCGATGAGCCCTTCCAGTACA NM_002080 CTCCAGCAACGTGGGCTACCTTGCCCATGC NM_002092 GGTCCCACGTTCATCATAGGTATATTGAAC NM_004493 GTGATGACCATTGCCCCAGGTCTGTTTGGC NM_004964 GACAAACGAATTGCCTGTGAGGAAGAGTTC NM_004494 CCAGGCATCAGAGATCATGAGAGCCTGTAG NM_002129 GCTGCATATCGTGCCAAGGGCAAAAGTGAA NM_031266 GCCCCGGCTACGACTACAGTCAGGGTAGTA NM_014413 GATGACGGAAAGGATGGGGGCGTGGGATGA NM_002568 CGCCCAGCTGCTCCTAGACCACCATTTAGT NM_198336 ACATAGGACGACAGTTAGCTATGGGTGTTC NM_000212 TTCACCAATATCACGTACCGGGGCACTTAA XM_290793 AGCGGGGAAGGAATGAAGCGTGTCCTGACT NM_005956 TCTGTGGCCAGTGAAATTATGGCTGTCCTG NM_005962 ACGCCTCTTCATTCCCGTCCATGCCGAGCC NM_000265 ACCAAGCGGAAGCTGGCGTCTGCCGTCTGA NM_005601 ATCCTCTTGCTCTGTACAGGTGCCCTGAGC NM_002512 GTCTTGTGCTCATGACTGGGTCTATGAATA NM_000270 AGCATTCCACTCCCTGACAAAGCCAGTTGA NM_004152 CTACACGTTCGAGAGAGAGTCTTCGGGAGA NM_001604 CCCATGCAGATGCAAAAGTCCAAGTGCTGG NM_002541 AAGCCAAGACTTCGGACCACCATCAGCCGC NM_013232 TACCTGTCCATGGTCTTCAGTATCGTATGA NM_000291 CCTGGGGTGGATGCTCTCAGCAATATTTAG NM_021129 AGACGTGGATAAGTGGTTCCATCACCAGAA NM_001198 GCCACCAACAGTGAAGAGGTTATTGGAGTG NM_006406 GGAAACCTGGTAGTGAAACAATAATCCCAG NM_002836 TTCAGGTAATTCTGACTCGAAGGACAGAAG NM_002871 GTGGCCTTGGAACGAGTTTCCCATGAGTAA NM_002881 TCAGCGAAGACCCGGGCCAACGTGGACAAG NM_005777 GCTGTTCGAAGAGTCATGTTTGCTCGATAT NM_004851 CTTCTTGGGGACGTATGTGGCCGTCTTCGA NM_004159 GCTGCGCCTTTAGATGACACGACCCTACCC NM_002923 CAAATCACCACAGAGCCTCATGCTACATGA NM_000976 AGTGGTGCTGTGGAATGCCCAGCCAGTTAA NM_000980 CGCTACGAGAGTACAAGGTAGTGGGTCGCT NM_000983 ACTGGTTGCGCGTAGTTGCTAACAGCAAAG NM_000969 AGAAGAAGGATCGGGTAGCTCAAAAGAAGG NM_000970 CGATCTGTGTTTGCTCTGACGAATGGAATT NM_000661 CTTGTTCAGTATCTCAAGCCCAGAAAGATG NM_002951 GTTGGCCCTGACAATCATAGCCAGCACCTG NM_001014 TGGAGGGTGAGCGACCTGCGAGACTCACAA NM_001021 CTTTTGGACTTCGGCAGTCTGTCCAACCTT NM_001028 ACCAGAAATACCAAGGGTGGAGATGCTCCA NM_001031 TCAGAGCGAGAAGCCCGGAGGTTGCGCTGA NM_001007 GAGACAAAAGACTGGCGGCCAAACAGAGCA NM_001009 CAAGGGCTCCTCGAACTCCTATGCCATTAA NM_001011 CGGGCAAGGATGTTAATTTTGAATTCCCAG NM_001013 GTCCTTCATTGTCCGCCTGGATTCCCAGAA NM_003011 CACGACGGGGCCGACGAGACCTCAGAAAAA NM_006427 GTGGGCAGATGCTGATTGGACCAGACGGCC NM_001636 CATGTACACGGGCACCGTCGACTGTTGGAG NM_006516 CATCCCCTGGGGGCTGATTCCCAAGTGTGA NM_002860 TTACTACTAAGTGGCTGCTGCGAGGGAAGG NM_003134 TAGAGCTAACATGGATGGGTTGAAGAAGAG NM_006280 CTTGGCCTTCAGTGCGAAGAGCCACATCCA NM_003153 CCACATGGACCTAAGGGCCAACCCCAGTTG NM_005801 GACGATCAGCTGAAGGTTCATGGGTTTTAA NM_003258 CAGATTCTGCAATGCAGCCCTGCCAACTGA NM_014220 CATATGTGGCTTTTGCTGCTCTCACCAACA NM_003318 GGTGGTGAAAGTCATAATTCTTCATCCTCC NM_006000 AGGTGGGCATCGACTCCTATGAGGACGAGG NM_006009 GCGTCCAACCTATACTAACCTGAATAGGTT NM_006002 GCGACCCTGATGAACTAAGATTTAATGCGA NM_006508 GCTGAGTTGCCCAAGGCCCAGATCAGCTGC NM_000375 AGTTTGCAGCCATCGGCCCCACTACGGCTC NM_003380 GAAACTTCTCAGCATCACGATGACCTTGAA NM_000377 GGAGCGCTTTTGGATCAAATCCGGCAGGGA NM_005080 AGACTACGTGCACCTCTGCAGCAGGTGCAG NM_153380 ACCTTCACCTGGAAGTCACGCCTCAATATA NM_012203 AGGGGAGCCGATGCCTAGTGAACTCAAGCT NM_001101 TCGAGCAAGAGATGGCCACGGCTGCTTCCA NM_001785 GGTACGTATATTGTCATGACGGTCCAGGAG NM_002341 AACATCAGTCACCCCGATATGGTGGACTTC NM_001152 CAAGGGTGCATGGTCCAATGTTCTCAGAGG NM_144488 GAGGCATGTACCTCACTCGCAACGGGAACC NM_021966 CTACCCTGATGGACGATACCGATCCTCAGA NM_002350 GAGATCCAACGTCCAATAAACAGCAAAGGC NM_001774 GTCTACAACCGGCTCGCTCGATACCGTTAG NM_013230 CTCACTCTCTCTTCTGCATCTCTACTCTTA NM_006325 AGAGGTTGCTCAGACAACTGCTCTCCCGGA NM_005340 CTTGGAGGTCGGCAAATGCATTGGCCTCCT NM_003039 GGCAACCCTGATAGCTGCCTTTGGGTCATC NM_002046 GTGGACCTCATGGCCCACATGGCCTCCAAG NM_000334 AGACTGTGCGCCCAGGTGTCAAGGAGTCTC NM_000484 AAGTGGTATAAGGAAGTACATTCTGGCCAG NM_170662 CCTCCAGTATCCCCACGTCTAAATCTATAG NM_006904 GAGAAGGCGGCTTACCTGAGTGATCCCAGG NM_133480 CACTTAGTGCCCACAACCGCACCAAGAAGC NM_000633 ACCCTGGGTGCCTATCTGGGCCACAAGTGA NM_002086 CCGAGAGAGTGAGAGCGCTCCTGGGGACTT NM_005248 GACTACTTCACCTCCGCTGAACCACAGTAC NM_002447 TCTCACCCATGCCAGGGAATGTACGCCGGC NM_003656 TGTTGCTGTCGAGACTGCTGCGTGGAGCCG NM_138980 GACCCTGGCATCTGACACTGACAGCAGCCT NM_016072 CCTTGGATCCCTCCTAAATTTACCTGGAAT NM_000785 CTGGTACCTGAAAGGAGCATCAACCTACAG AF200348 TATGAGAACCCTGGGGTGTTCTCCCCGGCC BC060842 GGCTACCCATACAGCTTTCTGATGAGTTAA NM_006302 GACCAGCCTTGTCTTACTGGCCATGGCTGA NM_020199 CCTAGATCAGAATGTTAATGAGGCAATGCC NM_024006 GTTTCCGGAAGGTCCAAGAACCCCAGGGCA NM_002229 CTGCTTGGGGTCAAGGGACACGCCTTCTGA NM_024099 CTAGTGAACCACAGCTCAAAAGGCAAAAGA NM_006378 TGTGAGCTGAAGTTCGCTGACTCAGACGCA NM_033334 GCACTATTTCTGTTTCAGATGATCGGGCTG NM_002814 GGCCAAAGGTGGCCTGGGTTTAATACTCAA NM_017771 GATGCTCATGTAAGCAGCTTTTCGAGAGAA NM_003002 CAACTATCACGATGTGGGCATCTGCAAAGC NM_003627 GTGCTTAGCGGCTCTGAGGTGACCGCATAG NM_005638 AGAAACATAGATCTGGTAGCTCAGCGAGGA NM_003288 CAGGAAACTCTTTCACAGGCAGGACAGAAG NM_003302 TCTCAGTTCCAGTTCCCATCCTTTGATTGA NM_016308 GGAAAAGAGAATTCAGACCTACCTTCAGTC NM_006113 GAGGCATTTGACTTGTTTGATGTTCGTGAC NM_006802 GAGGATCTGAAAAGACAAGGACTGCTCTAG NM_004184 GATGAGATAGTGAAAGAGTTCATGACTCCC NM_000089 CAAGGTCCAGTTGGCCGAACTGGAGAAGTA NM_004951 TTTCTAGTGCTGTGAAGTCAGCCCCTGAAG NM_002600 AGCATTCGGCAGCGTCGTCGCTTCACTGTG NM_005178 TCAGCTCCAATGGTCTTCTCTCCGCATCAC NM_001753 GCAATGTCCGCATCAACTTGCAGAAAGAAA NM_002414 CCAGCTGTTCAGCGTACTCTTTTAGAGAAA NM_001788 GAAAAACGTCGTCAGTTCGAGGATGAGAAA NM_016184 GAGCTGGTTCATACAACATTGGAGTGTGTG NM_005627 TATGCGCCTCCCACGGACTCTTTCCTCTGA NM_006329 ACTGCGGATATATGTGTCGCAGTACCCATT NM_016195 CTCTTCCTGACCCCCAGGAAGCTACTGCTT NM_006310 CTTCAGCGGAAGGCCTCACCACCCACAGTG NM_003707 GCTGACCAGCAGGATAAGTACATGAAGTGA NM_001845 CGTCAGCCGCTGCCAAGTCTGTATGAGAAG NM_006803 GCTGGCCATTTCTGGACTCAAGGTGAATCG NM_001219 CACCTACGGCTACGTTTTAGATGATCCAGA NM_001260 CAGTACTCACATCAGACACATCGGTACTGA NM_001916 ATAAAGCGGCACAAGTGGTCAGTCCTGAAG NM_000121 GCTTATCCGATGGCCCCTACTCCAACCCTT NM_002394 TTTCTGGTAGTGCTTAACTTTGGGGATGTG NM_004483 GATCAAGATGACACTGAGTAACCCTTCAGA NM_000521 GATGGTCGAACGTGGAATAGCTGCACAACC XM_167711 CTGACAAATGACAAGACCCCTGAGGCATGA AL833311 CCTGCTATCACACAGAACAACTTTCTAACC NM_013995 GTGCTGGTCTTTCAGGCTTGATTATCGTTA NM_024321 CAGAGAGCAGATTCCGCTCTCTCCTCTGCA NM_005952 TCCTGCTCGCCTGTTGGCTCCTGTGCCTGT NM_005375 CTACCAGTAAGACTGTCATCATGTGCTTGA NM_000946 CCGTGAATTGGATGCCATTTCCACTAATGA NM_004176 TGCTGCACGACTGTCAGCAGATGCTCATGC NM_002958 ACAGAGTTTCATGCAGCCCTGGGGGCCTAC NM_005063 CCAGGATTAAAAGAACCGGAGATGGAAACT NM_145341 CAGATACTGAATGTAAACCCTGCAGATCCT NM_003132 AAGTACTACAACTCCGACGTGCACCGCGCC NM_005100 CAGGAGGAGAACCGAAATATCGAACAGATT NM_021822 CCAGGACTACAGGGTTACCTGCTTCACCTC NM_020993 GCCTCTCAACAAAACTCCGAAGAGATGTAG NM_015099 GACCTGGATTGCACTTAAGTTTGCACTCTA NM_005127 CAGCAACAGCTAGATGTTACACCGAAAGAA NM_004010 CCAGCCTATTTCCTTAATGCTGTAAGGAGG NM_002305 ACCGTCAAGCTGCCAGATGGATACGAATTC NM_000237 GAAAGTGTCTCATTTGCAGAAAGGAAAGGC NM_006187 GCTGCATGGGACGGAATGGCATCCCCATCC NM_005419 GATGGACCCTTGATGCCTTCTGACTTCTAG NM_002576 CAGCTAAGGAGGCAACAAAGAACAATCACT NM_002390 ATTCGCCGAGGAAGGTCCGGAGGGGCCTAA NM_016187 GGTATCCACAAGTGAAAATCCACAACTCTG NM_014207 GACTATGATCTGCATGGGGCTCAGAGGCTG NM_005214 CCTCACAGCTGTTTCTTTGAGCAAAATGCT NM_003564 GGCTACGGGATGCCACGCCAGATCCTCTGA NM_002002 AGTCCATGGGACCTGATTCAAGACCAGACC NM_004001 ACGGCAGCGAAGCAGAGCTCCCTCGTTGGT NM_058176 GCCCTTCTAGGAAATGAGCTGGAGCCACTT NM_001558 CTCATCTCTAGCCTGCAGTCAAGTGAGTGA NM_006850 GGGAAGTGGACATTCTTCTGACCTGGATGC XM_042066 AAGCATCCAGTCTTTCGTACTACATGGTAG NM_033004 GTGGAACCTCAGGTGCAACAGAGACGCCAG NM_002835 CCAAGAGATCCACCTTCAGAATGGACATGA NM_000593 TGGAGAAAAAGGGGTGCTACTGGGCCATGG NM_002927 GGATTCCTACCCCAGATTTCTAAAGTCAGA NM_005012 GCCAATATTCATGGACACACCGAATCTATG NM_000655 CAGTGCTGTACTTGATGACAGACACTTCTA NM_005449 TCTGAATCTCCCTGGCTCCATGCCCCATCT NM_133378 GTCATGTATAACAAGTTTTCTGACCCTGCC NM_032663 CCCTCACACCAGTATTTATCCTTAACACTC NM_030753 GCCAGGAGTGTATTCGCATCTACGACGTGC NM_017935 CGACCCCAAGTTGAAAAGGAATTTGGTTTC NM_003202 ACAGGTGGCCTAGCAGGCACAGGACACCTG NM_030764 TGAATATCCCTGTGAGAATTCCAGTGTCTC NM_023109 CCATCTCAGTAGGGATCTAGCCACATCCCC NM_002738 ACCAGTCCTAACACCTCCTGACCAGGAAGT NM_006472 ACCACCGACTTATACTGAGGTGGATCCCTG NM_000417 GCCCCAGCTCATATGCACAGGTGAAATGGA NM_001775 GAGGATTCATCTTGCACATCTGAGATCTGA NM_005574 GCCTGGACCCTTCAGAGGAACCAGTGGATG XM_034274 CCAGTAGTACTTCAAGAGCTCTCATACTGT NM_001706 ACCAAGGTGCAATACCGCGTGTCAGCCACT NM_000902 AAACAGATGTGCACAGTCCAGGCAATTTCA NM_001102 ACGGCGCTGTACGGCGAGAGTGACCTCTAA NM_001718 GCGCCAACTAAGCTAAATGCCATCTCGGTT NM_033554 TCATAAAGTCTCTGCGTTCTGGCCATGACC NM_002122 CCTGTTCTCAGACAATTTAGATTTGACCCG NM_019111 CCTGTGGAACTGAGAGAGCCCAACGTCCTC NM_002124 CCACGTTTCTTGTGGCAGCTTAAGTTTGAA NM_014745 CTCACCAAGAAGTACAATCATCTCAACCTC NM_006993 ATCCTTCCTGCCAAAAAGCAGGGGGGCAGG NM_014366 TCTGAGGAGACTACAGCAGGTGAACAGTCT NM_003255 CAGGAGTTTCTCGACATCGAGGACCCATAA NM_002658 CACACTTCTTACCCTGGATCCGCAGTCACA NM_002704 GAACCCATTGCAACCAAGTCGAAGTGATAG NM_000090 TCGAGGATTCCCTGGTAATCCAGGTGCCCC NM_002026 AGGGAAATTCTTTGGAAGAAGTGGTCCATG NM_001766 AGGCAAACTTCCTATCAGGGCGTCCTGTGA NM_006614 TCTACAGCAACTTTTCCCCTTCGGGCATAA NM_004445 CCAAGTTTGGCCTCTGTACCTTCAGTGATG NM_006058 ACCAGAGCCAGCTGATCTCAGATTGCCAAG NM_052938 TCCAGGCTGAGGAAAGCAAACATTACAGAT NM_004126 AGCTTCGCAAAGAAGTGAAGTTGCAGAGAC NM_007360 GTGCACTCTATGCCTCGAGCTTTAAAGGCT NM_004225 ACCCACTGATCCAGCCCCCCTACGAGGTCT NM_005940 GGTCCTGACTTCTTTGGCTGTGCCGAGCCT NM_003800 CCTGGATGTTCTCTTATCTGGAATCCATCA NM_030956 GAGGTTCTACAATCTCTCTGATGAGAACAG NM_003453 CCTTGGAAAATATGCTTGTACGGGTTCTTC NM_018136 GGAAGAAATCACAAATCCCCTGCAAGCTAT NM_000682 ACTTCCGCCGTGCCTTCCGGAGGATCCTGT NM_181802 ATCCAGAGCCTTCTAGGAGAACCCAACATT XM_058619 CTCCACAAACTGGTTGTGCTCGGCACCTGA NM_018248 GCAAGCGTTCCACCATGAAAACAGTATTGA NM_000194 GACAAGTTTGTTGTAGGATATGCCCTTGAC NM_004526 GAGAAAGTGTCCAGCCGAGCCATCTTCACC NM_002426 CTTCCTACTCCAACGTATCACCAAAACACT NM_002608 TCTCTGCTGCTACCTGCGTCTGGTCAGCGC AF108138 TGTGCTGCACTTCTATGCCACCCTGCGGCG NM_002692 CTCTGCATAAACCCTGGCTCTTTTCCAAGA NM_003349 GTCACAAAGCAAACTGAGTGATGAAGGAAG NM_001067 GGGCAAAGAAACCTATAAAGTACCTGGAAG NM_013282 ACGTGAACAGACTCTGCCGGGTCTGCGCCT NM_002356 TCAAGAAGTCTTTCAAGCTGAGCGGCTTCT NM_002592 TACTTGGCTCCCAAGATCGAGGATGAAGAA NM_003113 GCTGCAGCTGACAAGCAGTTTTATGAAAAG NM_005292 GATCTGGTAGTCTACGGTCACTAAGCAATA NM_005192 GCAGAGTTGTCCAAACAGACACAGAAGAAC NM_000022 CCAGCAGCAGACCGTGGTAGCCATTGACCT NM_005163 CCACCTGACCAAGATGACAGCATGGAGTGT NM_001295 CCTCCACAGGGGAGCATGAACTCTCTGCTG NM_006887 ACAGCTACCTAAGCGGCTCCCTGAGCTCCG NM_005191 TTGAGAAGGGAAAGTGTACGCCCTGTATAA NM_006889 GCCCAGCGTGTTTTTAAAAGTTCGAAGACA NM_001846 ATCGAATGCAATGGAGGCCGCGGCACCTGC NM_002090 ATCGAAAAGATACTGAACAAGGGGAGCACC NM_004460 GGCCTGTCCACGAACCACTTATACACCCAC NM_032682 CTGGAAAACAGCCTAAAGAGCAACAGCAGG NM_006120 ACTCCTGGGCCGTCCCTGAAGCTCCTACTC NM_002120 CTGGTAATGAGGTCTCAAGAGCTGTTCTGC NM_006010 ACTGATGCCTAAATATGCCCCCAAGGCAGC NM_001560 GACTCTGTAGTGCTGATAGAAAACCTGAAG NM_172174 GGCATTCATGTCTTCATTTTGGGCTGTTTC NM_000632 CTTCAAGCGGCAATACAAGGACATGATGAG NM_004972 GGATCAAATAAGGGATAACATGGCTGGATG NM_004995 GCTCTACTGCCAGCGTTCCCTGCTGGACAA NM_172390 GACCTCTCCAGCACGAGCACCCACTCCTAG NM_005384 AGACTTATAGCCACACAACCAATCTCTGCT NM_001675 AAGGCAAGGGGGAAGAAAAGGGTCCCCTAG NM_000960 TCCAAAGCAGAAGCCAGCGTCGCCTGCTCC NM_000963 CCACAGTACTACTAAAAGAACGTTCGACTG NM_003037 TATGCTAGTGTGACACTTCCAGAGAGCTGA NM_018664 GCTGCTCAGAGAAGTCGGAAGAAGCAGACC NM_003121 CTCCGAAACTACGCCAAGACCGGCGAGATC NM_007315 GGCTCTGTAGAATTCGACAGTATGATGAAC NM_006290 CTACTGCAACGAATGCTTTCAGTTCAAGCA NM_007115 AATGGATCCTGTATCCAAATCCAGTCAAGG NM_012452 CAGACAGTGGCCTTGGCATTGTGTGTGTGC NM_003820 TCATTCACGGGGAGGAGCCCAAACCACTGA NM_005104 TCAGACACCAGTGATTCAGACTCAGGCTAA NM_000043 GCCAATTCCACTAATTGTTTGGGTGAAGAG NM_003326 GAATGGCGGAGAACTGATTCTTATCCATCA NM_005658 AATGTTCCTCAAGTGCATTGTGGAGACCAG NM_006060 AAGCATGGGCCTTCCGGGCACACTGTACCC NM_005608 GGAAGCCAGAGACAGTGACACGGAGGGCGA NM_005348 GTCGTGGAACAAAAGTTATCCTACACCTGA NM_000033 ACCCACCGGCCCTCCCTGTGGAAATACCAC NM_004915 TTCACTTCCCCGAGCTCCGGAGAGGGATGG NM_005186 AAGTGGTTGCAGCTGACCATGTTTGCATGA NM_005166 CGCGAACTGCAGCGGCACGGCTATGAGAAC NM_015193 GCAGCTCATCCAGAGGGGCATGGAGGTGCA NM_001178 GCAGCTCCACTGACTACCAAGAAAGCATGG NM_004317 CCATGAGGTGCGGGGGGCAGACAAGGTCAA NM_001187 GACGGCACAGCTCTGTGCTTCATCTTCTGA NM_172171 CGTGAGGCTCGGATATGTCGACTTCTGAAA NM_016280 ACCCACACCTCCTTGGCTCTATGCTCCTGA NM_000743 GAAACATCCGATCAAGAACCTGGGCTATGA NM_001762 TTCTCTTGGTTGATGAGATCATGCGAGCTG NM_000085 TTCATTCCCTCTTTGTGACGTCGCGGGGCA NM_001910 AAAACGCCATTGGGGCAGCCCCCGTGGATG NM_000778 CCTACCCACCTGTATCTCTTGTTGGGAGAA U53532 TTGTTTCGACGAGTTCAACCGGAATTCGTG NM_001939 TTCTGATGTGACTGCCAACACCCTGCTGGC NM_004091 TACGACCTTGGGGACCTGTTGATTAATTGA NM_001441 GAGTTGTGTCTGCGGTTCATGCGGGAGGTG NM_000148 TTAATGCAGACTTGTCTCCACTCTGGACAT NM_001777 AAGCTGTAGAGGAACCCCTTAATGCATTCA NM_002049 GTGCTGTCAGGGCCTGTTAGCCACCTCATG NM_002068 ACGCCTTTTCAGCCACTACACATGTGCCAC NM_005275 TGGCTGGCCGAAACCCTTATGCCCTGCTGG NM_002076 GCGGCAGTGTCAGGACTCGAAGATTTTCCA NM_005288 CCCCTCCATCTATACCTACGCCACCCTCCT NM_002094 TGCCTTGAGACCTTTAAAGACTTCCCTCAG NM_005513 TGGGACAACGCATGTTTGAGGACCTCTTTG NM_004963 GCACTCTGGAATACTTGCAGCTGAATACCA NM_000182 TAGTGGACCGGCTCAAGAAATATGAAGCTG XM_033511 CACTATGTCCCAAGATGGATTCCCAAATGA NM_006825 TGCCCTCGGCCAAACAAAGGGGCTCCAAGG NM_000867 CATTCTACTAGATACGCTTCTCCTCACTGA NM_006764 ACCAAGGCTCGAAGCCGTGTGCGGGACAAG NM_000612 CCCTGATTGCTCTACCCACCCAAGACCCCG NM_006083 AAGGGCGGAAAACCAGGCGCTTCAAGGAAA NM_006084 AGCAGGCCTTTGCCCGATACTTGCTGGAGC XM_045712 ATCGGCTCCCCAAGATTAAGGAAACCACAG NM_000229 ACCCTGTGGGTGTGCTCTATGAGGATGGTG NM_000234 TCAGAACCAACAAGGCGAGGACTCAGGCTC NM_025247 CTGGGAAAATGGAATGCAACCCACATTGTA NM_004255 GAACTGGGAATCTCCACTCCGGAGGAACTG NM_133259 CTGTCCCTTTCATTGAACCCCCTGAAAGCT NM_000239 CGTCAGTATGTTCAAGGTTGTGGAGTGTAA NM_005909 CAACATCATGGTTTTAGCAAGCAGCAGCAC NM_002379 GAAGCTGTGAGTAAGCGGCTGGCCATCCTG NM_002396 GCATCAAGCCCTCCTGTGATAACAGAATAG NM_139202 CCACTGCGGAACAGGAGTGACTCTGGCTGC NM_005936 GGTGTCATCCAGGTACGTTCCAGCCGGCCA NM_002421 GAAAGCTAATAGCTGGTTCAACTGCAGGAA NM_002476 TTCTTGCCCATCCTGCAGCACATTTCCCGC NM_002523 TCGATGTGTTCGGAGGGGCCTCCAAGTGGC NM_001862 TTGGCTGCACAAAGGCGAGGCCCAGCGATG NM_006981 CCTGCTTTCAAATGAATGATCAGGGTCTCT NM_002527 GCCTTGTCGAGAAAAATCGGAAGAACATGA NM_002557 GTAACCCCTCAAACAAGTCCTCTTTCTCTA NM_014735 GCCATGGTAAAAGCAAGACACATCCCCTTT NM_032940 TCTGCGTCCTGAAACCATTGTCCTGTCAGC NM_002739 CCAGGGCTTCACCTACGTGAACCCCGACTT NM_134260 GGAGGCAGAATGGCAAGCCACCATATTCAC NM_003973 AGCTCTCCTGAAAGCTTCTCCCAAAAAAGC NM_006642 TGAGACTGGCTGATGTTCAGAGCACTTACT NM_002640 TGGAGCCAAGATTCTGTGCAGACCACCCTT NM_004374 GGCATACGCAGATTTCTACAGAAACTACGA NM_005850 CCTATGCCTCCGCATGGTATGCGTGGACCT NM_000578 TCTGGACCTGTTGCCTTGCCCACGGAGCCA NM_014251 TATCTACCTCAAAGGCTATTGGTGGAGGCC NM_006841 CTATGCTTGGCTTCTTGCTGATGACCATGA NM_033262 GCCCCCGCATGGTGGATATGAGTTTTCAGA NM_014720 GAGGAGCTTGCACAAAGCCAGCATGCTCAG NM_006938 CAGTTTACCTCTGGATACACTACTTGTGGA NM_003107 TAACTTCGAGCCCGGCTCCGGCTCGCACTT NM_012448 AGTCAGTGGATCCCGCACGCACAATCGTGA NM_006453 TGGGAAACCCATAAAGGCGCACTGCCCTAG NM_003315 CTTTGAAGCATCTGGTCCAGGGAATTTCTT NM_170695 GTTGCACTCAAACGGGCTGCAGAGATGGAG NM_005077 ATGATAAGTACATAGTCACTGGCTCGGGGG NM_133502 GGAGGCAGAAGATTTCTGGCCAGTGGAGAG NM_003430 CTTTTAGCCATTCTTCAGCCCTTGCTAAAC NM_005157 CATGGGGGTCCACACTGCAATGTTTTTGTG NM_004418 TACCTCATGCAGAGATCGCCGTGTGCGGCTG NM_001719 AACCCGGAAACGGTGCCCAAGCCCTGCTGT NM_006835 TCCCCTTGTCCACCTTTGCAGCCTGTTTCT NM_000610 TACAAATACGGGTTCATCACTGATTCCACC NM_012287 CCCAAATGGCATCCAATAATCCAGAGAAAC NM_003879 GCCCATTGTCCTGATCTGAAAATTCTTGGA NM_005197 TGCTTTTGAATACTCCCCCTGAGATACAAG NM_001882 ATCGGGGAATTCTGTTTGTCTGGTCTTTGA NM_001319 GTGGAGGTGGCCGATGAAACCAAATGCTGC NM_001921 AACAGCAGACCGAGTCAAAAGCTTCAGTGA NM_006824 AGCAGATGAGGAAGGGGCCCAGTGCTAAAC NM_003648 ACGTCGGGTCAGATCCGACAGAAGACCATC NM_004441 GAGCCTGTATGTCTCTTCTTTCTGTCCGTG NM_002025 TGAGCAGAGCACCTTTTCCATCCCAGGACA NM_001530 ACTGCAGGGTGAAGAATTACTCAGAGCTTT NM_005531 GGGGAGTTGAGATCTGTAATTCATAGTCAC NM_000874 ACAGTCGTCCTGCCTAAGCTTCCCCAGTAG NM_014002 CGAACGGCTAAATAGAGTCCCAGCACCTCC NM_000628 ACTCTGAGAGCGGCAAGCAGAATCCTGGTG NM_000880 TGAACTGCACTGGCCAGGTTAAAGGAAGAA NM_001567 ACCCGGCTCACAAGCGCCTCCTTCTGGACA NM_001398 GACCTCGTGAAGTCGGTCCAGCCCACGACT NM_005544 CCACCCGCCGCTCAAGTGAGGATTTAAGCG NM_002249 CTCTTGGGGTTTGTACTCAAAGGACTCCAT NM_002755 CAGTGGAGTGTTCAGTCTGGAATTTCAAGA NM_003954 ACTCGGGCATCGACCTGCAGTGCACACTGG NM_002748 CCTCAAATTCCTCATCAAACATACAGCAGC NM_002408 GGGAGATATTAGGGACCATGAACTCTGTAA NM_004927 AGGAGCTTAAAGCCTGGCTCTTGGAGAAAG NM_004998 GACTACGAGGCAAGCCAGGGCTGTTCCCCA NM_003908 CGAGCACAGCTCCGTGCCAAAGCTAACTAA NM_005009 AGAGCAGTGAGCTGGTGAGCTGGGCAGACG NM_002542 GACTTCTTCCTCTAGACTTGGAGGGCCTCC NM_012383 ACTGCCTTATACTGGGCTTGCCACGGGGGC NM_005746 GATCTTCTCCATACTGTCTTCAAGAATGGC NM_002649 CATCTTGTTCTTGGCATCAAACAAGGAGAG NM_021127 GTCGAGTGTGCTACTCAACTCAGGAGATTT NM_006237 AAGCGGATGAAATTCTCTGCCACTTACTGA NM_003479 TACGCTTCAGAGATACCAATGGGCATTGCT NM_014369 GAGATAGAGAATGGGCGGAAAAGGTGTGAG NM_002828 CTTTTGTTGGCTGGAGACTGTTTTTTCAGC NM_001469 CTGCCGGGCTTACGGGCTGAAGAGTGGTCT NM_001754 GAAGCTTTCTCTAGGTGTAGCAGAAACTGC NM_006918 CTCAGTTATGTGAAGGAGATGACAGAGGGA NM_004630 CTCTCCTCACCCAACTCCCTTTGCCTCTCC NM_003105 CCAGGCTGGGGTCCGCAATCTTCTCCTCTG NM_004509 GCCTACTGTCATCCACAAAGCTCCTTTTTT NM_007237 GGTCAGTTTCTTGTTTCTCTACAGAGACCT NM_003120 ACCTACCAGTTCAGCGGCGAAGTGCTGGGC NM_182692 GGAATTCTTCAATCGCAGAGGAGAACTGCG NM_001066 GAATGTGCCTTTCGGTCACAGCTGGAGACG NM_003985 TCATCGAGGGCAGCTCCTCTTTCCACAGCC NM_006708 CTGATGATGGTAAAATGAAAGGCCTGGCAT NM_003387 CGGAGTGAGTATTTCTGCCAAGGTTTTTGA NM_003422 ATGGTCCCCTTGTGTATGCAGGGTTCGCGC NM_175870 TCAACCGTCATCCTTTCCCTCGTCCTGGCT NM_006748 TTCTCATCACCACCTTACTTTGAGGACTAG NM_001877 TCTCCTCCTGTGACTCGCTGCCCTAATCCA NM_000878 CAGGGTCAGGACCCAACTCACTTGGTGTAG NM_005923 CTAAGGGGAGGGATGCTGTGCACACTGTGG NM_000941 AGGCGGTGGACTACATCAAGAAACTGATGA NM_001242 TGCAGAGCCTTGTCGTTACAGCTGCCCCAG NM_006994 CAACAACCAATCAGAACCATAAGCTACAGG NM_001629 ACCATCTCCCCTCTACTTCTCATTCCCTAA NM_002107 CAGCTAGCACGCCGCATACGTGGAGAACGT NM_021603 TGACTGGGTTGTCGATGGACGGTGGCGGCA NM_003376 TCTGGGCTGTTCTCGCTTCGGAGGAGCCGT NM_000034 TCAAATCCAAGGGCGGTGTTGTGGGCATCA NM_004044 TGGCTCCCGGCCAGCTCGCCTTATTTAGTG NM_005998 AGAAAGGCGATGACCAGAGCCGGCAAGGCG NM_002156 GGTGCAATGGGTGGAATGGGAGGTGGTATG NM_002168 CCGTATTATCTGGCAGTTCATCAAGGAGAA NM_000884 CTCCATTCGTATGAGAAGCGGCTTTTCTGA NM_005566 TGGGGGATCCAAAAGGAGCTGCAATTTTAA NM_006636 GTCTAAAGAGCTTGGGGTAGCCACTAATTA NM_000269 CTGGTAGATTACACGAGCTGTGCTCAGAAC NM_002629 GGATGAAGAGACGGTGCGCAAAGCCATGGA NM_000365 CTCAAGCCCGAATTCGTGGACATCATCAAT NM_001148 GAGGACATCTTTGACACAAGGCCCATTTGG NM_138271 GAAAATCTCAAAAAACGCGGAGAAGATGGG NM_004049 ACACAGGAGAATGGATAAGGCAAAACGGAG NM_006624 CACAAGCAACTGATTTCTCAGACCAAGAAG NM_004166 TCCGGGAGTTCAGGATTGCATGAAAAAGCT NM_002989 AGGACTGAGCGGTCACAGACCCCTAAAGGG NM_003542 TAAAACGTCAGGGGCGCACTCTGTATGGCT NM_012073 GATTGATGACATTCGTAAGCCTGGAGAATC NM_000732 CCCCTCCGAGATCGAGATGATGCTCAGTAC NM_000733 TATTCTGGCCTGAATCAGAGACGCATCTGA NM_001781 ACAACTGGTTCAACGTTACAGGGTCTGACA NM_001809 CCAGGCCCTATTGGCCCTACAAGAGGCAGC NM_001280 AGACAGTTACGACAGTTACGCTACACACAA NM_007096 CCATCCTTGCTACAGCCTAGAACAGGCAGC NM_001891 CCACCCACCAGATCTACCCTGTGACTCAGC NM_001321 GGAGCAGGGGCTCTTGTTCATGCCCAGTAA NM_001908 GAATTCCACGCACCGATCAGTACTGGGAAA NM_005517 AACCACAGAGAAGATCCGCGAGGTTGTCTG NM_001909 TCTTCATCGGCCGCTACTACACTGTGTTTG NM_014750 GGAGACATCAAGAACATGCCAGACACATTT NM_004944 CCTTCACCAACAGCAAAAAATCTGTCACTC NM_004089 AGAGCCAGCTCCCGAATCCCCACAAGTGCC NM_004111 GGCAGCAGGGAAGTTTAAAAGGGGAAAATA NM_002036 TCTGGGTATGTCCTCCAGGCGGAGCTCTCC NM_006851 CCACGTAACAGATACACTTCTCTCTTTCTC NM_000405 AAGATCGCTGCCTCTCTAAAGGGCATATAG NM_002110 GGAGCGGCCGACCTTCGAATACATCCAGAG NM_005524 TCCTCATTCCCAACGGGGCCTTCGCGCACA NM_002136 CGGCTTTGGCGGTGGTAGTGGAAGCAATTT NM_145904 GAGGGGTGAGTCCCCTACTCCCTCTTCACT NM_005527 CTGCGGAACAGGGTATGTGCCTGGAAGGCC NM_007355 GATGCGTCTCGCATGGAAGAAGTCGATTAG NM_004258 GTGACCACAAATAGGAGGGAAGACGAGGAG NM_002194 CTGGTCCAAAACCTGGCACCTGCAGAGACG NM_000885 TCTCATATGTTATGTGGAAGGCTGGCTTCT NM_002306 GACCTCACCAGTGCTTCATATACCATGATA NM_002348 CTATACTCTGTGCTCTCCCAAGGATATGAG NM_005916 CTAGGAGACAAGGGGCAGACAGCTAGGACT NM_005520 TGTCAAACCAGTCCAGCTACGGGGGCCCAG NM_002397 TGTCTGAGGATGTCGACCTGCTTTTGAATC NM_014791 GGAAGACATCCTATCTAGCTGCAAGGTATA NM_000918 GCAGGGGATGATGACGATCTCGAGGACCTG NM_002627 TCAGGCCAGCTGGAACATGTGCAGCCCTGG NM_006219 AGGGAAAGCTGGACTACTAAAGTGAACTGG NM_002654 AACACCATGCGTGTTGTTCCTGTGCCGTGA NM_000302 TACATCGCAGTCTCCTTCGTCGATCCCTAA NM_002674 AGAGTCTACCGACCCTGTTGGCAAGTCTGA NM_002702 GCAATCGGCGCCAGACGCTCAAGAACACCA NM_002802 GAAGGCACCCCTGAGGGGCTGTATCTCTAA NM_005055 ATGACCGAGATCGGAAACCGCCTGGGGCAG NM_015004 GCCTCCTTGCAGAGTGTTCTGCACAAGGAA NM_002970 ATTTTACCTATGACCCGTGGATTGGCAAGT NM_005410 AAGCCAGTGCCAGTTGACGCTGAAAGAATC NM_005411 ATGGAGTGAGTCAGTGACAGGAGCAGCGAC NM_003034 GAAGATACCTCACTCCAGCCCACTTCCTAG NM_005628 AACCCCCTCCTCAAACACTATCGGGGGCCC NM_004955 AGAGACCGCAGGAGCCATCATGGCCTTCTT NM_031844 AGGTAAGAAGAAGGCGGAAGGCGGCGGAGG NM_003091 GATTGTCTGGTTTCCTTACAGGGCCCCCTC NM_004780 GCAAAACGGGGCGGTCCTTATCCTATTTAA NM_005650 GCAGAACAAGACCGCGAAAGGCAGCCTCAG NM_003249 TGCATCCTGAGACCCGGCGGTTCCGAGGAT NM_000074 ATGGCACTGGCTTCACGTCCTTTGGCTTAC NM_016292 AGGGCCATGGTGGGCCGCTTGAATGAGCTG NM_021643 GGAAGAGAACTTGGACCCTTTCTTTAACTG BX436497 AACCCAGCTCTCTGTCTTGGAGGACCTGAA NM_006088 ACAATGTGAAAACGGCTGTCTGTGACATCC NM_005347 ATGAAGCTCTCCCTGGTGGCCGCGATGCTG NM_003328 CTGGCACCAATGTCCATATATGAAGTCATG NM_007013 CATGAAAATGGAGAGCCTTCAGCAAGGACA NM_003441 AGACGGTCCACAGATCGGAGTCAACATAAG NM_021089 GGGTGCTTCCATGTTATTTGACATCAGAGA NM_004310 AGGAGACGAAACAGAAGGAGGCTCTTCTCC NM_016733 GGCACGGCTCTTGCTTCCGGTGTTCAGAAT NM_002818 GAGAAAATTGTCACCCCAAAGGGTGAAGAA NM_005018 TTCCTAGCGGAATGGGCACCTCATCCCCCG NM_002574 GACAAACATGGGGAAGTGTGCCCAGCTGGC NM_031966 TAGTTCAAGATTTAGCCAAGGCTGTGGCAA NM_006854 GTAGTCCAGACCATCCTATACTGTGACTTC NM_006332 TCCAGACCCTCGGCACCTGCTACTTACCAA NM_004619 AGATGACACTCTGTTCTTGAAAGTGGCCGT NM_016155 GGTCTGCTCATGCACCTCTGGGGCATCCTC NM_002659 TGTGAGGAAGCCCAAGCTACTCATGTATAA NM_000485 TGGCACCTGTACCCTTCTTCTCTCTCCTGC NM_006763 AAGAACTACGTGATGGCAGTCTCCAGCTAG NM_001743 ATCGATGGAGATGGCCAGGTCAATTATGAA NM_006191 GAGAATCCCACCAGTGGGGAAACATTAGAA NM_176783 CAGGGGAGAAACAAAGGGAATGATCTATTG NM_002961 CTTTGAAGGCTTCCCAGATAAGCAGCCCAG

The present invention further contemplates arrays that comprise an HCP combination as a subset of a larger collection of probes for applications other than profiling hematological cancers.

As indicated above, in addition to the polynucleotide probes of the HCP combination, the arrays can comprise one or more control probes. Controls that can be included on the arrays of this invention include hybridization controls, scanning controls, normalization controls, expression level controls and mismatch controls. The controls can be positive or negative controls, and may be selected to target bacterial sequences that are not found in humans. Examples of positive control target genes that can be included on arrays are found in Table 29 below. Examples of negative control target genes that can be included on arrays are found in Table 30 below.

TABLE 29 Exemplary positive control target genes Target Sequences (GenBank ™ Accession No.) Description NM_000518 Human gene sequence (Homo sapiens hemoglobin, beta (HBB), mRNA) NM_000518 Human gene sequence (Homo sapiens hemoglobin, beta (HBB), mRNA) NM_000518 Human gene sequence (Homo sapiens hemoglobin, beta (HBB), mRNA) NM_000518 Human gene sequence (Homo sapiens hemoglobin, beta (HBB), mRNA) NM_000518 Human gene sequence (Homo sapiens hemoglobin, beta (HBB), mRNA) CP000001 Bacterial sequence (Bacillus cereus E33L, complete genome) CP000001 Bacterial sequence (Bacillus cereus E33L, complete genome) CP000001 Bacterial sequence (Bacillus cereus E33L, complete genome) CP000001 Bacterial sequence (Bacillus cereus E33L, complete genome) CP000001 Bacterial sequence (Bacillus cereus E33L, complete genome) NC_007384 Bacterial sequence (lla sonnei Ss046, complete genome) NC_007384 Bacterial sequence (lla sonnei Ss046, complete genome) NC_007384 Bacterial sequence (lla sonnei Ss046, complete genome) NC_007384 Bacterial sequence (lla sonnei Ss046, complete genome) NC_007384 Bacterial sequence (lla sonnei Ss046, complete genome) AK152894 Mouse sequence (Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone: F830213J22 product: polynucleotide kinase 3′- phosphatase, full insert sequence) AK152894 Mouse sequence (Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone: F830213J22 product: polynucleotide kinase 3′- phosphatase, full insert sequence) AK152894 Mouse sequence (Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone: F830213J22 product: polynucleotide kinase 3′- phosphatase, full insert sequence) AK152894 Mouse sequence (Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone: F830213J22 product: polynucleotide kinase 3′- phosphatase, full insert sequence) AK152894 Mouse sequence (Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone: F830213J22 product: polynucleotide kinase 3′- phosphatase, full insert sequence) AK172558 Mouse sequence (Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone: F830213J22 product: polynucleotide kinase 3′- phosphatase, full insert sequence) AK172558 Mouse sequence (Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone: F830213J22 product: polynucleotide kinase 3′- phosphatase, full insert sequence) AK172558 Mouse sequence (Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone: F830213J22 product: polynucleotide kinase 3′- phosphatase, full insert sequence) AK172558 Mouse sequence (Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone: F830213J22 product: polynucleotide kinase 3′- phosphatase, full insert sequence) AK172558 Mouse sequence (Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone: F830213J22 product: polynucleotide kinase 3′- phosphatase, full insert sequence) NC_007292 Bacterial sequence (Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome) NC_007292 Bacterial sequence (Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome) NC_007292 Bacterial sequence (Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome) NC_007292 Bacterial sequence (Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome) NC_007292 Bacterial sequence (Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome)

TABLE 30 Exemplary negative control target genes Target Sequences (GenBank ™ Accession No.) DeSCRI10ption NC_007292 Bacterial sequence (Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome) NC_007292 Bacterial sequence (Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome) NC_007292 Bacterial sequence (Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome) NC_007292 Bacterial sequence (Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome) NC_007292 Bacterial sequence (Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_007384 Bacterial sequence (Shigella sonnei Ss046, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) NC_004547 Bacterial sequence (Erwinia carotovora subsp. atroseptica SCRI1043, complete genome) Bacterial sequence (E. coli rafA, rafB, and rafD genes encoding alpha-D- M27273 galactosidase, raf-permease, and raf-invertase, complete cds) Bacterial sequence (E. coli rafA, rafB, and rafD genes encoding alpha-D- M27273 galactosidase, raf-permease, and raf-invertase, complete cds) M27273 Bacterial sequence (E. coli rafA, rafB, and rafD genes encoding alpha-D- galactosidase, raf-permease, and raf-invertase, complete cds)

An example of a hybridization control would be to include several spots of the same polynucleotide probe on one chip, each spot containing a different amount of probe. This allows for the amount of probe of a given sequence to be optimized. Another example of a hybridization control is dimethyl sulfoxide (DMSO), which is used as a negative control (i.e. should give no signal), and can also be used as a scanning control. Plant or bacterial sequences having sufficiently low homology with human sequences can also be utilized as negative hybridization and scanning controls. If a signal is detected at a plant spot, this could indicate a problem with hybridization, i.e. too low a hybridization stringency was used, or with scanning, for example, the chip was inserted into the scanner at the incorrect orientation. Poly A can be used as a positive hybridization specificity/non specificity control. A poly A spot should always give intense hybridization, thus if no signal is detected at a poly A spot this could indicate use of too high a hybridization stringency.

Dyes, for example fluorescent dyes such as Cy3 or Cy5, can be incorporated into a nucleic acid sequence, such as a PCR product, and can be used as a positive scanning control for chip arrays that utilise these fluorescent dyes. Other detectable labels such as gold, for example colloidal gold or other particles, can also be used. A positive scanning control should always give a signal.

Normalization controls are nucleic acid probes that are complementary to labeled reference oligonucleotides or other nucleic acid sequences that are added to the test sample. The signals obtained from the normalization controls after hybridization provide a control for variations in hybridization conditions, label intensity, “reading” efficiency and other factors that may cause the signal of a perfect hybridization to vary between arrays. For example, signals (such as fluorescence intensity) read from all other probes in the array can be divided by the signal from the control probe(s) thereby normalizing the measurements.

Expression level controls are probes that hybridize specifically with constitutively expressed genes in the test sample. A variety of constitutively expressed genes known in the art can be used for expression level controls, for example, constitutively expressed “housekeeping genes” such as the β-actin gene, the transferrin receptor gene, the GAPDH gene, and the like. Mismatch controls may also be provided for the probes to the target genes, for expression level controls or for normalization controls. Mismatch controls are oligonucleotide probes or other nucleic acid probes identical to their corresponding test or control probes except for the presence of one or more mismatched base that are sufficient to prevent hybridization. Controls for arrays can be synthesized by standard techniques or purchased from a variety of commercial suppliers, for example, Stratagene (SpotReport™, La Jolla, Calif., USA). Other controls suitable for inclusion in arrays are known in the art.

The array may additionally comprise one or more probes each of which is targeted to a gene that is diagnostic of a hematological cancer on a general level, but which does not provide any information regarding the type/subtype, or other features of a hematological cancer. Examples of such these genes that relevant to lymphoma are listed in Table 31.

TABLE 31 Genes that show common expression patterns in all subtypes of lymphoma Symbol Modulation 11-Sep Over ABCC4 Under ABCD1 Under ADRB2 Under AKR1C3 Under ANXA1 Under ARRB2 Under ASPM Over BIRC5 Over C15orf20 Over CAT Under CCL5 Under CCNA2 Over CCNB1 Over CCR1 Under CD33 Under CD36 Under CDC2 Over CDC20 Over CDCA1 Over CDH5 Over CDKN3 Over CENPF Over CES1 Under CHEK1 Over CHN2 Under CIAS1 Under CLECSF6 Under CNN3 Over COL1A2 Over CSF3R Under CSPG2 Under CTGF Over CTSB Under CX3CR1 Under DAF Under DF Under DGKA Under DHFR Over DNAJB6 Under DOC1 Over DOK2 Under DPYD Under ENPP2 Over EVI2B Under FBN2 Under FEN1 Over FGR Under FLI1 Under FLNA Under FLPRL1 Under FN1 Over FOS Under GBA2 Under GEM Over GNS Under HAL Under HCK Under HHEX Under HIST1H2AC Under HOXA4 Over HOXA5 Over ID2 Under IGFBP7 Over IL2RA Over KIAA0247 Under KIF2C Over KLF4 Under LILRB3 Under MBNL1 Under MCM2 Over MCM5 Over MGC5395 Under MLC1SA Over MMP9 Over MSN Under MYO1B Over NRIP1 Under P2RY5 Under PCAF Under PCDH9 Under PF4 Under PFC Under PLAU Over POLD2 Under PPBP Under PTGDR Under PTPN12 Under RAB13 Over RELB Over RGL1 Over RNASE1 Over RNASE2 Under RPS6KA1 Under S100A12 Under S100A4 Under S100A6 Under SAMHD1 Under SATB1 Under SELPLG Under SERPING1 Over SESN3 Over SFRS3 Over SLC11A1 Under SMTN Over SNX2 Under SPIB Over SYNPO Over TBC1D8 Under TCF4 Over TDO2 Over TIE1 Over TM4SF2 Over TRIP6 Over TXNIP Under VIPR1 Under WEE1 Over

2.1 Preparation of the HCP Array

The HCP arrays can be prepared using one or a combination of standard array synthesis methods known in the art, such as spotting technology or solid phase synthesis.

For example, the HCP array can be synthesized either in situ (see, for example, Hughes, T R, et al. Nature Biotechnology, 19:343-347 (2001)) or by conventional synthesis followed by immobilization onto the substrate, for example using robotic spotting. Other in situ synthesis or depositing technologies currently being used to manufacture oligonucleotide-based chips and could be used to prepare the HCP arrays of the present invention (see for example, Lockhart D J, et al., Nat. Biotechnol. 1996 December; 14(13):1675-80 and Yershov G, et al., Proc Natl Acad Sci USA. 1996 May 14; 93(10):4913-8). Many kits and packages for preparing arrays are commercially available, for example, the Pronto!™ Microarray Printing kit (Promega, Madison, Wis.). In addition, many companies provide custom array synthesis services.

Detailed discussion of methods for attaching nucleic acids to a solid substrate can be found in, for example, U.S. Pat. Nos. 5,837,832; 5,215,882; 5,707,807; 5,807,522; 5,958,342; 5,994,076; 6,004,755; 6,048,695; 6,060,240; 6,090,556 and 6,040,138.

2.2 Testing of HCP Arrays

HCP arrays can be tested for their ability to detect the expression pattern of genes in the one or more HCP sets that they represent using methods known in the art and one or more appropriate biological samples. Appropriate biological samples include those listed above in section 1.3.1. For example, blood or tissue samples from patients with a hematological cancer, or samples from cultures of cell lines as described in section 1.3.1, can be used to prepare labelled RNA samples. These labelled RNA samples can be hybridized to the HCP array to determine the expression pattern of the genes targeted by the HCP combination on the array according to methods known in the art.

3. Methods of Profiling Hematological Cancers

The system of the present invention further provides for methods of profiling hematological cancers using the HCP combinations or HCP arrays described above. These methods provide for the determination of the expression pattern of genes of one or more HCP sets in a test sample taken from a subject having, suspected of having, or suspected of being at risk of developing, a hematological cancer. In general such methods involve contacting a test sample with an HCP combination or HCP array under conditions that permit hybridization of the probe(s) in the combination or array to any target nucleic acid(s) present in the test sample and then detecting any probe:target duplexes formed as an indication of the presence of the target nucleic acid in the sample. Expression patterns thus determined can be compared to one or more reference expression patterns to provide information relating to the features of the hematological cancer(s) under investigation.

A test sample can be contacted with each probe in an HCP combination sequentially or simultaneously. Contacting a test sample with an HCP array, for example, allows for the simultaneous analysis of several features of one or more types of hematological cancers. In one embodiment of the present invention, the methods employ an HCP array. In another embodiment, the methods allow for the screening of several features of one or more types of hematological cancers in a single assay.

3.1 Test Samples

Test samples suitable for use in the methods of the present invention comprise nucleic acids that provide gene expression information (i.e. comprise mRNA, or nucleic acids derived from mRNA). The test sample can be, for example, a blood or biopsy sample taken from the subject to be profiled. A biopsy sample can comprise, for example, cells or tissue from a hematological cancer.

The test sample can be a biological sample that is used directly in a method of the invention, or it can be a biological sample that is submitted to one or more preparation steps, for example, the test sample may be submitted to an enrichment or culture step to increase the number of cells in the sample; to one or more extraction, purification, and/or amplification steps to isolate, purify and/or amplify nucleic acids in the sample, to one or more reverse transcription or transcription steps, or combinations of these procedures and thereby provide a test sample for use in the methods of the invention.

For example, if required, nucleic acids for use in the methods of the present invention can be isolated from the sample according to one or a combination of a number of methods well known to those of skill in the art (see, for example, Laboratory Techniques in Biochemistry and Molecular Biology: Hybridization With Nucleic Acid Probes, Part I. Theory and Nucleic Acid Preparation, P. Tijssen, ed. Elsevier, New York, N.Y. (1993)). For example, cDNA corresponding to the mRNA in the test sample can be prepared by reverse transcription of the mRNA, and the resulting cDNA can be utilised in the methods of the invention. Alternatively, RNA can be transcribed from the cDNA using in vitro transcription techniques to provide cRNA, or DNA can be amplified from the cDNA using standard amplification methodology, such as PCR. The resulting cRNA or amplified DNA can then be used in the hematological cancer profiling methods. In the above cases, the isolated nucleic acids provide a test sample suitable for used in the methods of the present invention.

The test sample can also include control nucleic acids. For example, to ensure that any amplification and/or labeling procedures do not change the true distribution of target nucleic acids in a sample. For this purpose, a sample can be spiked with a known amount of a control polynucleotide and a control probe that specifically hybridizes to the control polynucleotides. After hybridization and processing, the hybridization signals obtained from the hybridised control polynucleotide and probe should reflect accurately the amount of control target polynucleotide added to the sample. Other controls are known in the art and can be included in the test sample.

Prior to using the test sample in the profiling method, it may be desirable to fragment the nucleic acids in the test sample. Fragmentation can improve hybridization by minimizing secondary structure and cross-hybridization to other nucleic acids in the test sample or to non-complementary polynucleotide probes. Fragmentation can be performed by mechanical or chemical means known in the art.

The nucleic acids in the test sample can be labeled if necessary with one or more detectable labels to allow for detection of hybridized probe/target duplexes. A detectable label is a moiety that can be detected by spectroscopic, photochemical, biochemical, bioelectronic, immunochemical, electrical, optical, chemical means and the like. Examples include, but are not limited to, radioisotopes, chemiluminescent compounds, labeled binding proteins, heavy metal atoms, spectroscopic markers (such as fluorescent markers and dyes), magnetic labels, linked enzymes, mass spectrometry tags, spin labels, electron transfer donors and acceptors, colloidal particles, and the like. Exemplary dyes include quinoline dyes, triarylmethane dyes, phthaleins, azo dyes, cyanine dyes and the like. Non-limiting examples of fluorescent markers include fluorescein, phycoerytirin, rhodamine, lissamine, Cy3 and Cy5. Biotin and colloidal gold are also suitable for labeling the nucleic acids in the test sample. Methods of labeling nucleic acids are well known in the art.

3.2 Hybridization and Detection

The hybridization and detection steps of the methods of the present invention can be carried out using standard techniques known in the art. In general during the hybridization step, the test sample is contacted with an HCP combination under conditions that permit hybridization of the probes in the combination to their target sequences. Hybridization can be, for example, standard solution hybridization, utilizing an HCP combination of probes in solution, or array hybridization utilizing an HCP array.

Examples of solution hybridization techniques contemplated by the present invention include, but are not limited to, Northern analysis, clone hybridization, cDNA fragment fingerprinting, subtractive hybridization, differential display, differential screening and combinations of these techniques (see, for example, Lockhart and Winzeler (2000) Nature 405:827-836, and references cited therein). Such methods are well known in the art.

In solution hybridization techniques the probes can be labeled with a detectable label, for example, a radioisotope, fluorophore, chemiluminophore, enzyme, colloidal particle, and fluorescent microparticle, antigen, antibody, hapten, avidin/streptavidin, biotin, enzyme cofactor/substrate, and the like. Alternatively, the presence of a probe:target hybrid can be detected using an intercalating dye such as ethidium bromide, SybrGreen, SybrGold, and the like.

Other techniques include those based on the polymerase chain reaction (PCR) and other amplification technologies, such as in vitro transcription (IVT), NASBA and other isothermal amplification techniques. Such methods typically involve reverse transcriptase-PCR (RT-PCR), in which cDNA is prepared from the test sample mRNA by reverse transcription using a poly-dT oligonucleotide primer, and the cDNA is then subjected to PCR. The PCR product is then detected using probes of the HCP combination. As indicated above, the probes can be labeled or unlabeled probes can be used in combination with an interchelating dye. If desired, the PCR product can be evaluated in real-time using methods known in the art, for example using techniques involving fluorescence resonance energy transfer (FRET), in which case, the probes could be TaqMan® probes, molecular beacon probes, Scorpion probes, or the like. Technology platforms suitable for analysis of PCR products include the ABI 7700, 5700, or 7000 Sequence Detection Systems (Applied Biosystems, Foster City, Calif.), the MJ Research Opticon (MJ Research, Waltham, Mass.), the Roche Light Cycler (Roche Diagnostics, Indianapolis, Ind.), the Stratagene MX4000 (Stratagene, La Jolla, Calif.), and the Bio-Rad iCycler (Bio-Rad Laboratories, Hercules, Calif.). Molecular beacons and other sensitive probes can also be used to detect the presence of a nucleic acid sequence in a mRNA or cDNA sample that has not been submitted to an amplification step.

Alternatively, the hybridization and detection steps can involve standard array-based techniques in which an HCP array of the invention is employed. Such array-based techniques generally involve contacting a test sample with the array under hybridization conditions, whereby complexes are formed between the polynucleotide probes on the HCP array and any complementary target nucleic acid molecules in the test sample. The presence of probe:target complexes is then detected, either qualitatively or quantitatively. Specific hybridization technology which may be practiced to generate the expression patterns are well known in the art, and include the technology described in U.S. Pat. Nos. 5,324,633; 5,470,710; 5,492,806; 5,525,464; 5,800,992; as well as WO 95/21265; WO 96/31622; WO 97/10365; WO 97/27317; and EP 373 203.

3.3 Determination of the Expression Pattern

The level of gene expression of one or more target genes in the test sample being evaluated, or the “expression pattern,” can be evaluated by qualitative and/or quantitative measures. Qualitative techniques detect differences in expression and classify these differences in expression into distinct modes without providing significant information regarding quantitative aspects of expression. For example, a technique can be described as a qualitative technique if it detects the presence or absence of expression of a gene sequence, i.e. an on/off pattern of expression. Quantitative techniques rate expression on a scale, for example, a scale of 0-5, a scale of 1-10, a scale of +−+++, from grade 1 to grade 5, a grade from a to z, or the like. It will be understood that the numerical, and symbolic examples provided are arbitrary, and that various graduated scales (or symbolic representations of graduated scales) can be employed in the context of the present invention to describe quantitative differences in gene expression. Typically, such techniques yield information corresponding to a relative increase or decrease in expression with respect to an appropriate control.

Various techniques known in the art that yield either quantitative or qualitative expression data are suitable for evaluating gene expression in a test sample in the methods of the present invention. In some cases, for example, when multiple techniques are employed to determine expression patterns of target genes, the determined expression pattern may be the result of a combination of quantitative and qualitative data.

3.4 Data Analysis

Once the expression pattern for the test sample has been determined, it can be compared with one or more reference or control expression patterns using methods known in the art. The increase or decrease in the level of expression of the various genes being interrogated with the HCP combination provides information relating to one or more features of a hematological cancer in the subject from which the test sample was taken. A reference or control expression pattern in the context of the present invention is an expression pattern obtained from probing a sample taken from an individual known to exhibit a particular feature of the hematological cancer under investigation (a positive reference or control expression pattern) or a sample taken from an individual known to lack a specific feature of the hematological cancer (a negative reference/control pattern). Alternatively, the reference may be the expression pattern obtained from probing a test sample taken from the same individual at a different time point, for example at an earlier stage in the disease, or prior to a particular therapy or treatment, and can thus act as a reference for whether the disease has progressed in that individual and/or to investigate the effects of a certain treatment. It will be readily apparent that when multiple features of a specific hematological cancer are being investigated that an expression pattern determined using the methods of the invention may need to be compared to several references in order to obtain information relating to all features under investigation. The methods of the present invention are also suitable for providing reference or control expression patterns.

In certain embodiments, the expression pattern determined from the test nucleic acid sample is compared to a single reference/control pattern to determine a feature of a hematological cancer. In other embodiments, the expression pattern determined from the test nucleic acid sample is compared to two or more different reference/control patterns to determine features of a hematological cancer. For example, the expression pattern determined from the test sample may be compared to a positive and negative reference pattern to obtain confirmed information regarding a feature of a hematological cancer.

The comparison of the expression pattern determined from the test sample and the one or more reference/control patterns can be performed using a number of methodologies known in the art, for example, by comparing digital images of the expression patterns, by comparing databases of expression data, etc. Patents describing ways of comparing expression patterns include, but are not limited to, U.S. Pat. Nos. 6,308,170 and 6,228,575.

The comparison step results in information regarding how similar or dissimilar the obtained expression pattern is to the control/reference patterns, which similarity/dissimilarity information is employed to determine the feature of the hematological cancer. For example, similarity with a positive control indicates that the test sample has the feature(s) of the hematological cancer present in the control sample. Likewise, dissimilarity with a positive control indicates that the test sample lacks these feature(s) of the hematological cancer.

Depending on the type and nature of the reference/control pattern(s) to which the expression pattern determined from the test sample is compared, the above comparison step yields a variety of different types of information regarding the test sample that is assayed. As such, the above comparison step can yield information regarding multiple features of hematological cancers.

It is contemplated that one or more databases of reference/control expression patterns can be compiled and that the expression pattern of a test sample can be carried out using a computer program that compares the expression pattern of the test sample with those in the database. This type of analysis would allow information regarding the features of the hematological cancer under investigation to be obtained rapidly and would further provide for rapid throughput of multiple test samples.

3.5 HCP Signatures

As noted above, the methods and system of the present invention can be used to determine the expression pattern of genes from one or more HCP sets by probing a test sample with an HCP combination. Once a representative number of test samples have been probed, the expression pattern obtained from each test sample for the genes from the one or more HCP sets can be analysed in order to identify “HCP signature genes” that represent one or more features of a hematological cancer. HCP signature genes are identified on the basis of the extent that the level of expression of the gene changes when compared to the control. For example, statistical analysis can be employed in order to determine which genes show a statistically significant change in expression level over the control. Alternatively, a pre-determined differential expression limit can be imposed as a “cut-off” value. In one embodiment, HCP signature genes are defined as genes that show at least a 2-fold change in expression level relative to the control. In another embodiment, HCP signature genes are defined as genes that show at least a 3-fold change in expression level relative to the control. In a further embodiment, HCP signature genes show at least a 5-fold change in expression level. In a further embodiment, HCP signature genes show at least a 10-fold change in expression level. The change in expression level demonstrated by an HCP signature gene can be an increase in expression or a decrease in expression relative to the control.

The combination of the HCP signature thus identified represents a refined HCP set that can be used to define an expression pattern profile, or “HCP signature,” that is specific to the one or more features of a hematological cancer of interest. This HCP signature can be used as a reference expression pattern considered indicative of one or more feature of a hematological cancer, and thus be compared to the expression pattern obtained from a test sample in order to determine whether the test sample has one or more features of the hematological cancer. The number of genes represented in an HCP signature can vary between about 10 and about 500. In one embodiment, the number of genes represented in an HCP signature is between about 20 and about 300. In another embodiment, the number of genes represented in an HCP signature is between about 30 and about 200. In a further embodiment, the number of genes represented in the HCP signature is between 30 and about 160.

Representative examples of HCP signatures are depicted in Tables 32-41 below.

TABLE 32 DLBCL Signature (≧2-fold relative to control) [51 genes] Overexpressed Underexpressed Symbol Symbol ABTB2 ABCB1 BASP1 BCL2 BIK BTBD3 CCNE2 CASP10 CD22 CDC25B CDCA7 CLECSF2 CDK4 CSTA CKS1B EBI2 CYP27B1 EPHB6 DNMT3B GNG11 E2F5 ICAM2 FAP IL10RA GRHPR LYN IL1R1 MLLT2 LOC90925 MRPL33 MAD2L1 PDCD4 MCM4 PRKCQ MCM7 RORA MMP12 SFRS7 MS4A1 SFRS9 NME1 TES PARP1 TGFBR2 PLCG2 TGFBR3 POLE2 RGS13 TERF2 TOP2A TRAF1

TABLE 33 FL Signature (≧2-fold relative to control) [70 genes] Overexpressed Underexpressed Symbol Symbol ABTB2 ABHD3 ARID5B ADAM10 BASP1 ASB7 BIK BIN2 CCL19 BZRP CD19 CASP3 CD22 CYBB CD24 DAXX CD81 EMP3 CDCA7 HK2 CLU HSPA6 CR2 IFI30 CTLA4 IL15 E2F5 KLRK1 FCER2 LGALS1 GCET2 LYN GPR18 MRPL33 GYPC NKG7 IGJ NPC1 IL1R1 P4HA1 IRF8 PRKCD KHDRBS3 RBBP4 KIAA0746 SERPINA1 LOC90925 SFRS7 LPL SYBL1 MAGED1 TGFBR3 MCM4 TIGD7 MS4A1 TLE1 OSBPL10 TNFSF10 PARP1 TYROBP PIK3C2B WARS POSTN RGS13 SPAP1 TIMD4 TNFRSF7 TRAF1 TRAF5 UBE2J1

TABLE 34 HL Signature (≧2-fold relative to control) [33 genes] Overexpressed Underexpressed Symbol Symbol AKR1C1 13CDNA73 APOC2 CDKN2D CCL19 CSTA CD81 EBI2 CTLA4 GNG11 CYP27B1 HSPA6 DHCR24 KLRK1 FLJ40504 LYN GSTT1 MRPL33 IL1R1 PISD KIAA0992 SORL1 LGMN STS-1 MMP12 TGFBR3 NFKBIA PIK3C2B PRAME SLAMF1 STAT1 TFF3 TRAF1

TABLE 40 AML Cell Line Signature (≧5-fold relative to control) [129 genes] Overexpressed Underexpressed GenBank ™ GenBank ™ Symbol Accession No Symbol Accession No BIRC5 NM_001168.1 AKAP12 AI672553.1 BZRP NM_007311.2 ANXA1 NM_000700.1 C13orf18 NM_025113.1 APOBEC3G NM_021822.1 C3orf6 AK055652.1 ASPM NM_018136.2 CDC20 NM_001255.1 AUTS2 NM_015570.1 CDC6 NM_001254.2 BASP1 NM_006317.3 CDCA7 NM_031942.3 BCL2A1 NM_004049.2 CDKN3 NM_005192.2 BIRC3 NM_001165.3 CHEK1 NM_001274.2 BTK NM_000061.1 CLIC5 AL049313.1 CASP4 AL050391.1 CSF1R NM_005211.2 CCL5 NM_002985.2 DMD NM_000109.2 CCNA2 NM_001237.2 FGR NM_005248.1 CD2 NM_001767.2 HCK NM_002110.2 CD24 NM_013230.1 IL16 NM_004513.3 CD36 NM_001001547.1 KNTC2 NM_006101.1 CD3D NM_000732.2 LGALS1 NM_002305.2 CD44 NM_000610.3 LGALS3 NM_002306.1 CD79B NM_000626.1 LILRB1 AI523104.1 CD86 NM_006889.2 NKG7 NM_005601.3 CDC2 NM_001786.2 PCDH9 BC042366.1 CDCA1 NM_031423.2 PLA2G7 NM_005084.2 CR2 NM_001877.2 PLCG2 NM_002661.1 CSF3R NM_156038.2 PON2 NM_000305.1 CSTA NM_005213.2 PPBP NM_002704.2 CTGF NM_001901.1 PRKCD NM_006254.3 CX3CR1 NM_001337.2 PTPN6 NM_002831.3 CXCR4 NM_003467.1 PTPRC NM_002838.2 DNTT NM_004088.2 RAB13 NM_002870.2 EBI2 NM_004951.2 RAG2 NM_000536.1 ENPP2 NM_006209.2 S100A6 NM_014624.2 ENTPD1 NM_001776.3 SERPINA1 NM_000295.3 FCER2 NM_002002.3 SFRS3 BE927772.1 FLJ40504 NM_173624.1 SPAP1 NM_030764.2 GUCY1A3 NM_000856.1 SPIB NM_003121.1 HCLS1 NM_005335.3 TCF4 AI307786.1 HIST1H2AC BC050602.1 TCF7 NM_201632.1 HIVEP2 NM_006734.2 TIMP1 NM_003254.1 HLA-DMA NM_006120.2 TLE1 NM_005077.3 HLA-DPA1 NM_033554.2 HLA-DPB1 NM_002121.4 HLA-DRA NM_019111.2 IFI30 NM_006332.3 IFI44L NM_006820.1 IGJ NM_144646.2 IL10RA NM_001558.2 KIF2C NM_006845.2 KLRK1 NM_007360.1 KRT19 NM_002276.3 LCK NM_005356.2 LTB NM_002341.1 LY86 NM_004271.1 MAD2L1 NM_002358.2 MAL NM_022438.1 MBNL1 NM_021038.3 MGMT NM_002412.2 MS4A1 NM_021950.2 MT1G NM_005950.1 MYL4 W04885.1 NAPSA NM_004851.1 NCF4 NM_013416.2 P2RY5 NM_005767.3 PF4 NM_002619.1 PLAU NM_002658.1 POLE2 NM_002692.2 PRAME NM_006115.3 PSPH NM_004577.3 PTPRCAP NM_005608.1 RGL1 NM_015149.2 RIPK2 NM_003821.4 RNASE1 NM_198232.1 S100A12 NM_005621.1 S100A4 NM_002961.2 SAMHD1 NM_015474.2 SERPINB1 NM_030666.2 SERPING1 NM_000062.1 SESN3 BU929213.1 SLA NM_006748.1 SLAMF1 NM_003037.1 SLC1A4 NM_003038.2 SORL1 U90916.1 STMN1 NM_005563.3 SWAP70 AB014540.1 TCL1A NM_021966.1 TFRC NM_003234.1 TOP2A NM_001067.2 TRIP6 NM_003302.1 TXNIP NM_006472.1 TYROBP NM_003332.2 VEGF BC058855.1 ZAP70 NM_001079.3

TABLE 41 T-ALL Cell Line Signature (≧5-fold relative to control) [111 genes] Overexpressed Underexpressed GenBank ™ GenBank ™ Symbol Accession No Symbol Accession No BIRC5 NM_002102.2 AKAP12 W04885.1 C13orf18 NM_001168.1 ANXA1 NM_013230.1 C3orf6 NM_001255.1 APP NM_173624.1 CD74 NM_006101.1 ASPM BC058855.1 CDC20 NM_001254.2 AUTS2 NM_002358.2 CDC6 NM_001274.2 BASP1 NM_018136.2 CHEK1 NM_000536.1 BCL2A1 NM_006845.2 CLIC5 NM_004088.2 BIRC3 NM_031966.2 CSF1R NM_201632.1 BTK NM_001237.2 DNTT NM_005601.3 CASP4 NM_001067.2 FGR NM_002838.2 CCL5 NM_003234.1 GYPE AL049313.1 CCNA2 NM_001786.2 IL16 AI307786.1 CCNB1 NM_002692.2 KNTC2 NM_000305.1 CD2 NM_004577.3 LILRB1 AK055652.1 CD24 NM_022438.1 NKG7 NM_002870.2 CD36 NM_006748.1 PCDH9 NM_025113.1 CD37 NM_004615.2 PLCG2 NM_002661.1 CD3D NM_000700.1 PON2 NM_003121.1 CD44 NM_000732.2 PTPRC NM_004513.3 CD86 NM_003467.1 RAB13 AI523104.1 CDC2 NM_001767.2 RAG2 NM_004355.1 CNN3 NM_005356.2 SERPINA1 BC042366.1 CSF3R NM_006734.2 SPIB NM_005248.1 CSTA NM_001079.3 TCF4 NM_001242.3 CTGF NM_005608.1 TCF7 NM_005211.2 CXCR4 NM_005531.1 TNFRSF7 NM_000295.3 EBI2 NM_012151.2 ENG AI672553.1 ENPP2 BU929213.1 ENTPD1 NM_005965.3 F8A1 NM_000237.1 FCER2 NM_001839.2 FLJ40504 NM_006209.2 FN1 NM_000062.1 HCK NM_212474.1 HCLS1 NM_001901.1 HIST1H2AC NM_003302.1 HIVEP2 NM_003821.4 HLA-DMA BC050602.1 HLA-DPA1 NM_015149.2 HLA-DPB1 NM_021966.1 HLA-DRA NM_002002.3 IFI16 NM_006317.3 IFI30 NM_006120.2 IFI44L NM_001774.1 IGJ NM_144646.2 IL10RA NM_021950.2 KIF2C NM_002341.1 KLRK1 NM_013416.2 LCK NM_005213.2 LPL NM_015570.1 LTB U90916.1 LY86 NM_004049.2 MAD2L1 NM_015474.2 MAL NM_004951.2 MBNL1 NM_003037.1 MS4A1 NM_156038.2 MYL4 NM_001776.3 MYLK NM_004851.1 NAPSA NM_000484.2 NCF4 NM_006820.1 POLE2 NM_000061.1 PSPH NM_002985.2 PTPRCAP NM_001558.2 RGL1 NM_000610.3 RIPK2 NM_004271.1 S100A12 AB014540.1 S100A4 NM_001165.3 SAMHD1 NM_006889.2 SERPING1 NM_002110.2 SESN3 NM_005335.3 SLA NM_007360.1 SLAMF1 NM_000118.1 SORL1 AL050391.1 SWAP70 NM_001001547.1 TCL1A NM_005621.1 TFRC NM_021038.3 TM4SF2 NM_006332.3 TOP2A NM_002961.2 TRIP6 NM_006472.1 TXNIP NM_003332.2 TYROBP NM_033554.2 VEGF NM_002121.4 ZAP70 NM_019111.2

TABLE 35 MCL Signature (≧2-fold relative to control) [80 genes] Overexpressed Underexpressed Symbol Symbol 3.8-1 13CDNA73 ADAM19 ABHD3 ARHGAP24 AHR BANK1 BIN2 BASP1 CAMK1 C13orf18 CCND3 C3orf6 CD58 CACNB2 CD86 CD19 CSTA CD22 FAS CD24 GATA3 CD79B HBS1L CELSR1 IFI30 CR2 IL1B DNMT3A LGALS2 E2F5 MAPKAPK3 GM2A MLLT3 GTF2E2 MRPL33 HLA-DOB NKG7 ITGAD NUCB2 KCNN4 PISD KIAA0355 PRKCQ KIAA0746 S100A10 LOC55565 SERPINA1 LOC90925 SERPINB1 LPL SERPINB8 MCM7 SLAMF1 MGC39372 SORL1 MME STAT5B KIAA0504 TNFSF10 MS4A1 TYROBP MYH11 WARS NAPSA NFATC1 NFKBIE OSBPL10 PARP1 PDLIM1 PIK3C2B PLCG2 RASA1 SPAP1 SYK TNFRSF13B TNFRSF7 TRAF5 UNG ZNF177

TABLE 36 MZL Signature (≧2-fold relative to control) [159 genes] Overexpressed Underexpressed SYMBOLol Symbol ABTB2 13CDNA73 AKR1C1 ABCB1 APOC2 ABHD3 APOD ANXA5 ARID5B APC BAIAP2L1 APOBEC3G BASP1 ARF6 BIK ARID4A BTG2 ASB7 C13orf18 BCL2A1 C3orf6 BLVRB CCL19 C5orf15 CD19 CAMK1 CD209L CASP3 CD22 CCND3 CD24 CCNG2 CD72 CCR5 CD79B CCT6A CDCA7 CD86 CDK4 CLECSF2 COL9A2 CYBB COL9A3 DCK CR2 EIF4A2 CRYM ELF1 CSNK1E FKBP5 CTSD GLUD1 DBN1 GMPS DHCR24 GNG10 DMD GNG11 DNMT3B HIST1H2BK DVL2 HSPCA E2F5 HSPH1 EPHB6 IL15 FCER2 IL8 FLJ40504 IQWD1 FSCN1 ITGB1 GM2A KLRK1 GSTT1 LGALS3 HIP1R LOC54103 HLA-DOB LTBP1 HLA-DQA1 LYN IGHM MAFB IGJ MAPK9 ITGAD MGC5395 ITIH3 MLLT2 KCNN4 MYC KHDRBS3 NFE2L2 KIAA0746 NFE2L3 KRT5 NKG7 LOC55565 NPC1 LOC90925 NT5E LPL NUCB2 MAGED1 P4HA1 MCM7 PBX3 MME PIK3CA MS4A1 PPM1B NFATC1 PRDM2 NME1 PROS1 OSBPL10 PTPRC PIK3C2B RBBP4 PLK3 RBM12 PRKCB1 RORA PTPN7 S100A10 RASA1 SAFB RASGRF1 SELL RGS13 SERPINA1 SH3BP5 SERPINB1 SLC38A3 SFRS9 SPAP1 SORL1 SYK STAT3 TCL1A SYBL1 TFF3 TEGT TNFRSF13B TES TNFRSF7 TNFSF10 TRAF5 TOP2B TYMS TYROBP WNT10A UBE2D2 WNT5B WAC YWHAE WARS ZBTB16

TABLE 37 SLL Signature (≧2-fold relative to control) [128 genes] Overexpressed Underexpressed Symbol Symbol 3.8-1 ABCB1 AKAP12 ABHD3 AKR1C1 ADAM10 ARID5B ANXA5 BIK BCL2A1 C13orf18 BID C3orf6 BIRC2 CACNB2 BTBD3 CCL19 CAMK1 CCNE1 CASP3 CD19 CCNG2 CD209L CCR5 CD22 CD86 CD24 CLU CD72 CSF1R CD79B CSTA CDK4 CYBB COL9A2 EBI2 COL9A3 EIF4A2 CR2 FKBP5 CSNK1E GATA3 CTSD HK2 DMD HLA-DRB1 DNMT3B HSPA5 E2F5 HSPH1 FCER2 IFI30 FLJ40504 IL15 CS0DC015YK09 IL1B HIVEP2 IL8 HLA-DOB IQWD1 HLA-DQA1 ITGB1 IGFBP4 LGALS1 IRF8 LGALS2 KCNN4 LGALS3 KIAA0746 LTBP1 LOC55565 MLLT2 LPL MLLT3 MS4A1 MYC MYH11 NFE2L2 NFATC1 NKG7 NFKBIE NPC1 NME1 NUCB2 OSBPL10 P4HA1 PBP PRKCD PLK3 PTPRC POLE2 RBM12 PRKCB1 RORA PTPN7 S100A10 RASA1 SAFB RASGRF1 SERPINA1 SH3BP5 SERPINB1 SLC38A3 SFRS9 SPAP1 SLC20A1 SYK SORL1 TCL1A STAT5B TFF3 SYBL1 TNFRSF7 TEGT TOSO TES TRAF5 TGFBR2 UNG TIMP1 WNT10A TNFSF10 ZNF177 TOP2B TRA1 TYROBP WARS ZBTB16

TABLE 38 TCL Signature (≧2-fold relative to control) [92 genes] Overexpressed Underexpressed Symbol Symbol AKR1C1 13CDNA73 BAD BACH2 CCL19 BANK1 CCL8 BCL6 CDC6 BTK CDCA4 CCNG2 CDK4 CD69 CDKN1A CD79B CKS1B CLECSF2 CKS2 CYBB DBN1 DGKD DHCR24 EBI2 DNMT3B EIF4A2 DXS9879E FCER2 E2F2 IFI16 FAP ITGB1 GSTT1 KLRK1 H2AFX LOC54103 HLA-DQA1 LOC90925 IL15RA LTBP1 IL6 LY64 KIAA0992 LY86 LARGE LYN MAD2L1 MIR MCM4 MLLT2 MT1G MS4A1 MT1H NAP1L1 NID2 NAPSA NME1 NFATC1 PARD3 NFE2L2 PNAS-4 NUCB2 POLE2 PDCD4 POSTN PRDM2 PSPH PTPRC RAMP3 SAFB SLC38A3 SELL TIMP1 SERPINB1 TPM4 SFRS9 UBE2J1 SORL1 WNT5B SP110 SPAP1 STARD7 SWAP70 SYK TCL1A TEGT TES TGFBR2 TGFBR3 TLE1 TNFSF10 ZNF91

TABLE 39 CLL Signature (≧5-fold relative to control) [66 genes] Overexpressed Underexpressed GenBank ™ GenBank ™ Symbol Accession No. Symbol Accession No BAIAP2L1 NM_018842.3 ANXA1 NM_000700.1 C3orf6 AK055652.1 BCL2A1 NM_000484.2 CD74 NM_004355.1 CCNA2 NM_004049.2 CDCA7 NM_031942.3 CD24 NM_001237.2 CDKN3 NM_005192.2 CDC2 NM_013230.1 CLIC5 NM_016184.2 CSF3R NM_001786.2 CNN3 AL049313.1 ENTPD1 NM_156038.2 COL1A2 NM_001839.2 EN1 NM_001776.3 CX3CR1 NM_000089.3 APP NM_212474.1 ENPP2 NM_001337.2 STMN1 NM_005531.1 GATA3 NM_006209.2 IFI16 NM_001558.2 HCK NM_002051.2 IL10RA NM_007360.1 IGFBP7 NM_002110.2 KLRK1 NM_000237.1 ITGAL NM_001553.1 LPL NM_002341.1 LGALS2 T28925.1 LTB NM_002358.2 LGALS3 NM_006498.1 MAD2L1 NM_021038.3 LOC54103 NM_002306.1 MBNL1 NM_002619.1 MT1H AI523104.1 PF4 NM_002692.2 NK4 T66903.1 POLE2 NM_006115.3 NKG7 NM_005951.1 PRAME NM_004577.3 PLA2G7 NM_004221.3 PSPH NM_005608.1 PLAU NM_005601.3 PTPRCAP NM_015149.2 PON2 NM_005084.2 RGL1 NM_003821.4 PPBP NM_002658.1 RIPK2 NM_005621.1 PRKCD NM_000305.1 S100A12 NM_006748.1 SPAP1 NM_002704.2 SLA U90916.1 SPIB NM_006254.3 SORL1 NM_005563.3 STAT1 NM_030764.2 SWAP70 AB014540.1 TCF4 NM_003121.1 TFRC NM_003234.1 TLE1 AK022231.1 TRAF1 NM_005658.2 TNFSF10 AI307786.1 ZAP70 NM_001079.3 TRIP6 NM_005077.3 TYROBP NM_003810.2 CLECSF6 NM_003302.1 LILRB1 NM_003332.2

4. Profiling of Hematological Cancers

The HCP system of the present invention provides for the profiling of a hematological cancer in a subject with respect to one or more features of the hematological cancer. Hematological cancers that can be profiled using the system of the present invention are selected from the group of lymphoma or leukemia. The information provided by the hematological cancer profiling methods has a number of applications, for example, in disease prognosis, diagnosis, staging or grading, treatment management, monitoring of disease progression, predicting disease outcome or complications, pharmacogenomics, and the like. Treatment management, for example, includes selecting the most appropriate drug(s) or other therapy for effective treatment of the hematological cancers. Predicting disease outcome can involve, for example, predicting a patient's chance of survival, relapse, or the likelihood of disease progression.

For example, the expression pattern of genes in one or more HCP sets in a test sample obtained from a patient suspected of having a hematological cancer can be compared to the expression pattern of genes in the same HCP set(s) in samples from control subjects. Examples of control subjects include, but are not limited to, subjects known to have a specific hematological cancer, healthy subjects, subjects having a hematological cancer at a defined stage or grade, subjects having drug-resistant, multi-drug resistant or drug-sensitive hematological cancer, subjects undergoing a defined chemotherapy regimen, untreated subjects having a hematological cancer, subjects having a specific subtype of a hematological cancer, and the like. Similarly, for some treatments with known side effects, the HCP combination can be employed to “fine tune” the treatment regimen. A dosage is established that causes a change in gene expression patterns indicative of successful treatment. Expression patterns associated with undesirable side effects are avoided. This approach may be more sensitive and rapid than waiting for the patient to show inadequate improvement, or manifest symptoms, before altering the course of treatment.

As the HCP combinations of the present invention allow for the simultaneous investigation of several features of a hematological cancer in a single assay, the information obtained from a single assay may be applicable in several areas. Thus, the HCP system of the present invention provides for methods of diagnosing a hematological cancer, typing a hematological cancer, monitoring progression of a hematological cancer, monitoring the rate of progression of a hematological cancer, predicting therapeutic outcome, determining prognosis, monitoring response to treatment, predicting survival, selecting appropriate drug(s) and/or therapies for treatment, and combinations thereof.

In addition, the present invention also contemplates that the methods can be used in drug discovery and development, toxicological and carcinogenicity studies, forensics, and the like, wherein the test sample may be taken from either an in vitro cell culture, or from a human or other animal subject. For example, expression patterns relating to the effects of currently available therapeutic drugs can be investigated. Test samples obtained from individuals treated with these drugs can be analyzed and compared to samples from untreated patients. In this way, an expression pattern of known therapeutic agents will be developed. Knowing the identity of sequences that are differentially regulated in the presence and absence of a drug will allow researchers to elucidate the molecular mechanisms of action of that drug. Similarly, large numbers of candidate drugs can be screened based on the expression pattern similar to those of known therapeutic drugs, with the expectation that molecules with the same expression profile will likely have similar therapeutic effects. Thus, the invention provides the means to determine the molecular mode of action of a drug.

5. Other Uses of the HCP Combinations

The HCP system of the present invention further provides for the nucleotide sequences of the HCP combination in computer-readable media for in silico applications and as a basis for the design of gene-specific primers for amplification of one or more genes of an HCP set.

Gene-specific primers based on the nucleotide sequences of genes of the HCP sets of the system can be designed for use in amplification of the genes of the HCP set. For use in amplification reactions such as PCR, a pair of primers will be used. The exact composition of the primer sequences is not critical to the invention, but for most applications the primers will hybridize to specific genes of the HCP set under stringent conditions, particularly under conditions of high stringency, as known in the art. The pairs of primers are usually chosen so as to generate an amplification product of at least about 50 nucleotides, more usually at least about 100 nucleotides. Algorithms for the selection of primer sequences are generally known, and are available in commercial software packages. These primers may be used in standard quantitative or qualitative PCR-based assays to assess gene expression levels of genes of the HCP set. Alternatively, these primers may be used in combination with probes, such as molecular beacons, as described supra, in amplifications using real-time PCR.

6. HCP Profiling Kits and Packages and Computer-Readable Media

The present invention further provides for kits and packages for the profiling of hematological cancers in a subject comprising the probes of an HCP combination. The probes can be provided in the kit immobilized to a solid substrate (i.e. as an HCP array) or in the form of isolated nucleic acids suitable for use in solution hybridization assays, or in the preparation of an HCP array. Where appropriate, the HCP probes provided in the kit may incorporate a detectable label, such as a fluorophore, radioactive moiety, enzyme, biotin/avidin label, chromophore, chemiluminescent label, or the like, or the kit may include reagents for labeling the probes. The probes can be provided in separate containers or pre-dispensed into a convenient format for subsequent use, for example, into microtitre plates.

The kits can optionally include additional reagents, such as buffers, salts, enzymes, enzyme co-factors, substrates, labels, detection reagents, and the like. Other components, such as buffers and solutions for the isolation, treatment or amplification of a test sample, may also be included in the kit, for example, the kit may contain reagents for reverse transcription, transcription and/or PCR, including enzymes, primers and nucleotides. The kit may additionally include one or more controls. One or more of the components of the kit may be lyophilised and the kit may further comprise reagents suitable for the reconstitution of the lyophilised components.

The various components of the kit are provided in suitable containers. Where appropriate, the kit may also optionally contain reaction vessels, mixing vessels and other components that facilitate the preparation of reagents or the test sample.

The kit can optionally include instructions for use, which may be provided in paper form or in computer-readable form, such as a disc, CD, DVD or the like.

The present invention further contemplates that the kits described above may be provided as part of a package that includes computer software to analyze the gene expression patterns generated from the use of the kit.

The present invention further provides a computer-readable medium comprising one or more digitally-encoded HCP signatures, each signature being associated with one or more values and each value representing the expression of a gene represented by the HCP signature which is correlated with a feature of the hematological cancer represented by the HCP signature. Such a computer-readable medium can be used as a reference to compare the expression profile for the genes of a HCP signature generated from profiling a test sample. The digitally-encoded HCP signatures can be comprised in a database (such as the database described in U.S. Pat. No. 6,308,170).

The invention will now be described with reference to specific examples. It will be understood that the following examples are intended to describe embodiments of the invention and are not intended to limit the invention in any way.

EXAMPLES Example 1 Selection of Genes for an HCP Set Specific for DLBCL

Genetic profiling studies of hundreds of DLBCL patient samples has distinguished several subtypes of DLBCL: a type derived from differentiated activated peripheral blood b-cells (ABC), a second type derived from the undifferentiated germinal centers of lymph nodes (GC), a third type called Mediastinal Large B-Cell Lymphoma (MLBCL), and a fourth category that remains largely heterogeneous (Rosenwald A, Wright G, Chan W C et al. N Engl J Med. 2002; 346(25):1937-47; Rosenwald A, Wright G, Leroy K. et al. J Exp Med. 2003; 198(6):851-62; Wright G, Tan B, Rosenwald A, et al. Proc Natl Acad Sci USA. 2003; 100(17):9991-6; Savage K J, Monti S, Kutok J L, et al. Blood. 2003; 102(12):3871-9). These studies show that patients with GC-DLBCL have a significantly better survivability than patients with ABC-DLBCL. Savage et al. also presented a genetic signature for MLBCL that allows it to be distinguished from DLBCL.

Genes specific for DLBCL were selected by mining public databases. The genes are listed in Table 6 and include genes in the following categories.

ABC vs. GC DLBCL: These genes distinguish between ABC and GC subtypes of DLBCL. Each one of these two subtypes of DLBCL express genes with a specific expression pattern. The genes chosen for this section are unique to either ABC or GC DLBCL and can therefore be used to distinguish the two diseases, as described in Alizadeh A A, Eisen M B, Davis R E et al. Nature. 2000; 403(6769):503-11; Rosenwald A, Wright G, Chan W C et al. N Engl J Med. 2002; 346(25):1937-47; Wright G, Tan B, Rosenwald A, et al. Proc Natl Acad Sci USA. 2003; 100(17):9991-6; Shipp M A, Ross K N, Tamayo P et al. Nat Med. 2002 January; 8(1):68-74; and Pan Z, Shen Y, Du C, et al. Am J Pathol. 2003; 163(1):135-44.

DLBCL vs. FL: FL is closely related to DLBCL. The genes in the DLBCL vs. FL section allow identification of the two major types of disease, as well as give us the ability to predict whether or not a particular FL will progress into the more aggressive DLBCL (Shipp M A, Ross K N, Tamayo P et al. Nat Med. 2002 January; 8(1):68-74; Lossos I S, Alizadeh A A, Diehn M, et al. Proc Natl Acad Sci USA. 2002; 99(13):8886-91; de Vos S, Hofmann W K, Grogan T M, et al. Lab Invest. 2003; 83(2):271-85).

MLBCL vs. DLBCL: Similar to the last category, these genes separate DLBCL from Mediastinal Large B-cell Lymphoma (Savage K J, Monti S, Kutok J L, et al. Blood 2003; 102(12):3871-9; Kossakowska A E, Urbanski S J, Watson A, et al. Oncol Res. 1993; 5(1):19-28).

SURVIVAL: Shipp et al. correlated patient survival with a group of 96 marker genes; these genetic markers have the ability to predict a patient's life expectancy with significance and have therefore been included in our chip (Shipp M A, Ross K N, Tamayo P et al. Nat Med. 2002 January; 8(1):68-74).

Other genes, such as those described in Nishiu M, Yanagawa R, Nakatsuka S, et al. Jpn J Cancer Res. 2002; 93(8):894-901, can also be selected indicate the advancement of DLBCL within the sample.

Example 2 Selection of Genes for an HCP Set Specific for FL

Follicular lymphoma is an indolent or slow growing cancer that is the result of a t(14;18) translocation mutation in genomic DNA. FL accounts for 25-40% of all non-Hodgkin's lymphomas. Though FL is slow growing and 60-70% of patients live longer than five years after diagnosis, it is nonetheless incurable; patients endure continued relapse and decreased sensitivity to therapy until succumbing to disease. FL transforms into a more aggressive form of large b-cell lymphoma in 25-60% of patients (Lossos I S, Alizadeh A A, Diehn M, et al. Proc Natl Acad Sci USA. 2002; 99(13):8886-91).

Lossos et al. performed genetic profiling experiments on FL patients and tracked their progress to observe transformation into DLBCL. They found that follicular lymphomas that transformed into DLBCL de-regulated a particular gene signature that could be identified by microarray analysis. The genes chosen for this section have been shown to predict which cases will transform from FL into DLBCL. Several other teams have investigated the gene expression profile of FL in comparison with DLBCL, Burkitt's lymphoma and normal germinal center B-cells. Some of the genes in this set form a signature pattern enabling diagnostic separation of FL tissue from healthy samples and several other types of lymphoma (Shipp M A, Ross K N, Tamayo P et al. Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat Med. 2002 January; 8(1):68-74; Lossos I S, Alizadeh A A, Diehn M, et al. Proc Natl Acad Sci USA. 2002; 99(13):8886-91; Maesako Y, Uchiyama T, Ohno H. Cancer Sci. 2003: 94(9):774-81; Ghia P, Boussiotis V A, Schultze J L, et al. Blood. 1998; 91(1):244-51; Akasaka T, Lossos I S, Levy R. Blood. 2003; 102(4):1443-8; Elenitoba-Johnson K S, Gascoyne R D, Lim M S, et al. Blood 1998; 91(12):4677-85).

Genes specific for FL were selected by mining public databases. The genes are listed in Table 7 and include genes in the following categories.

DLBCL vs. FL: The genes in the DLBCL vs. FL section allow identification of the two major types of disease, and the prediction of whether or not a particular FL will progress into the more aggressive DLBCL (Shipp M A, Ross K N, Tamayo P et al. Nat Med. 2002 January; 8(1):68-74; Lossos I S, Alizadeh A A, Diehn M, et al. Proc Natl Acad Sci USA. 2002; 99(13):8886-91; Husson H, Carideo E G, Neuberg D, et al. Blood. 2002; 99(1):282-9; Lestou V S, Gascoyne R D, Sehn L, et al. Br J Haematol. 2003; 122(5):745-59; Ghia P, Boussiotis V A, Schultze J L, et al. Blood. 1998; 91(1):244-51).

BCL6 TRANSLOCATION PARTNERS The t(14;18) translocation mutation characteristic of FL deregulates the BCL6 gene. The genes contained in this set are linked closely with BCL6 and thus may be deregulated following the initial mutation. Expression data from these genes may show that they are important in the FL signature (Akasaka T, Lossos I S, Levy R. Blood. 2003; 102(4):1443-8).

FL vs. BURKITT'S Maesako et al., discovered a subset of genes that were deregulated when expression data of either FL or Burkitt's lymphomas were compared. Genes in this set will help separate FL samples from Burkitt's (Maesako Y, Uchiyama T, Ohno H. Cancer Sci. 2003; 94(9):774-81).

Example 3 Selection of Genes for an HCP Set Specific for CLL

Chronic Lymphocytic Leukemia is the most common type of human leukemia representing 30% of adult leukemia (Hamblin T J, Davis Z, Gardiner A, et al. Blood. 1999; 94(6):1848-54). In similar fashion to DLBCL and FL, the clinical outcome of CLL patients can vary greatly. Hamblin and his colleagues (1999) discovered that the overall survival of patients afflicted with this disease is correlated with the mutational status of the immunoglobulin V(H) genes; CLL patients whose cells had unmutated Ig V(H) cells had poorer clinical outcomes than patients whose B-cells had already undergone somatic mutation (Hamblin T J, Davis Z, Gardiner A, et al. Blood. 1999; 94(6): 1848-54).

Thus, CLL is a heterogeneous disease with at least two subtypes that are molecularly distinguishable. The genes chosen for this section reflect this hypothesis and have been selected because they were found to be related to both survival and Ig mutational status. Analyzing the expression pattern of genes selected for this set will make it possible to distinguish indolent and aggressive forms, thus assisting clinicians in forming an accurate and suitable treatment regimen (Rosenwald A, Alizadeh A A, Widhopf G, et al. J Exp Med. 2001; 194(11):1639-47; Hamblin T J, Davis Z, Gardiner A, et al. Blood. 1999; 94(6):1848-54; Damle R N, Wasil T, Fais F, et al. Blood. 1999; 94(6):1840-7; Wiestner A, Rosenwald A, Barry T S, et al. Blood. 2003; 101(12):4944-51; Nagy B, Ferrer A, Larramendy M L, et al. Haematologica. 2003; 88(6):654-8; Cro L, Guffanti A, Colombi M, et al. Leukemia. 2003; 17(1):125-32; Thieblemont C, Chettab K, Felman P, et al. Leukemia. 2002; 16(11):2326-9; Korz C, Pscherer A, Benner A, et al. Blood. 2002; 99(12):4554-61).

Genes specific for CLL were selected by mining public databases. The genes are listed in Table 5 and include genes in the following categories.

MUTATIONAL STATUS These genes are differentially regulated between IgV mutated and unmutated CLLs and allow us to differentiate between the two. Since IgV mutation has also been correlated with survival, these genes may also serve as prognostic markers (Rosenwald A, Alizadeh A A, Widhopf G, et al. J Exp Med. 2001; 194(11):1639-47).

CLL vs. DLBCL A number of genes were discovered to distinguish between CLL and DLBCL (Rosenwald A, Alizadeh A A, Widhopf G, et al. J Exp Med. 2001; 194(11):1639-47; Wiestner A, Rosenwald A, Barry T S, et al. Blood. 2003; 101(12):4944-51; Korz C, Pscherer A, Benner A, et al. Blood. 2002; 99(12):4554-61).

CLL vs. MCL Korz et al., performed real time reverse transcription PCR analysis on a number of genes and discovered those that were significantly deregulated between MCL and CLL (Thieblemont C, Chettab K, Felman P, et al. Leukemia. 2002; 16(11):2326-9; Korz C, Pscherer A, Benner A, et al. Blood. 2002; 99(12):4554-61).

Example 4 Selection of Genes for an HCP Set Specific for MCL

Mantle Cell Lymphoma affects 6% of non-Hodgkin's patients but accounts for a disproportionately larger number of deaths because it is an incurable malignancy. Within the population affected by the disease, some patients succumb in under a year while others survive for much longer. The median survival for patients with MCL is approximately 3 years (Rosenwald A, Wright G, Leroy K. et al. J Exp Med. 2003; 198(6):851-62). Rosenwald et al. and Martinez et al (Martinez N, Camacho F I, Algara P, et al. Cancer Res. 2003; 63(23):8226-32) have performed gene expression analysis on a number of samples and have correlated survivability with the up or down regulation of certain genes. Rosenwald and his team discovered that by observing the expression of 20 genes that function to govern the proliferation, or rate of growth and multiplication of cells, one is able to predict a patient's survival on a significantly accurate level. Martinez and her team performed a similar study and discovered 25 different genes that were able to perform a similar function.

MCL also has a subtype known as MCL-BV for Mantle Cell Lymphoma Blast Variant. MCL-BV has been shown to be more aggressive and result in poorer clinical outcome than non BV MCL. A paper by de Vos lays out the genes deregulated in MCL-BV that are correlated with more aggressive progression of disease. Other genes in this set have been discovered to be differentially regulated between MCL and other lymphomas such as DLBCL, MZL, and CLL. The expression pattern of genes selected for MCL may allow diagnosis of MCL from a variety of other lymphomas and result in an accurate prognosis based on the expression of certain molecular markers (Rosenwald A, Wright G, Leroy K. et al. J Exp Med. 2003; 198(6):851-62; de Vos S, Hofmann W K, Grogan T M, et al. Lab Invest. 2003; 83(2):271-85; Thieblemont C, Chettab K, Felman P, et al. Leukemia. 2002; 16(11):2326-9; Korz C, Pscherer A, Benner A, et al. Blood. 2002; 99(12):4554-61; Robetorye R S, Bohling S D, Morgan J W, et al. J Mol Diagn. 2002; 4(3):123-36; Martinez N, Camacho F I, Algara P, et al. Cancer Res. 2003; 63(23):8226-32; Kobayashi T, Yamaguchi M, Kim S, et al. Cancer Res. 2003; 63(1):60-6).

Genes specific for MCL were selected by mining public databases. The genes are listed in Table 9 and include genes in the following categories.

SIGNATURE The genes as described in Thieblemont C, Chettab K, Felman P, et al. Leukemia. 2002; 16(11):2326-9; Korz C, Pscherer A, Benner A, et al. Blood. 2002; 99(12):4554-61; Robetorye R S, Bohling S D, Morgan J W, et al. J Mol Diagn. 2002; 4(3):123-36; and Kobayashi T, Yamaguchi M, Kim S, et al. Cancer Res. 2003; 63(1):60-6, have been shown to be deregulated between a MCL and a variety of other lymphomas (MZL, CLL, DLBCL) and thus should be able to distinguish an MCL positive sample.

MCL vs. MCL-BV Genes as described in de Vos S, Hofmann W K, Grogan T M, et al. Lab Invest. 2003; 83(2):271-85, distinguishes between the aggressive MCL-BV or the more indolent form, MCL.

SURVIVAL Certain genetic markers have been correlated with a patient's overall survival after diagnosis. The genes incorporated into this section of the chip will be able to give a patient a prognosis based, not only on morphological studies, but on minute molecular changes (Rosenwald A, Wright G, Leroy K. et al. J Exp Med. 2003; 198(6):851-62; Martinez N, Camacho F I, Algara P, et al. Cancer Res. 2003; 63(23):8226-32).

Example 5 Selection of Genes for an HCP Set Specific for HL

Hodgkin's lymphoma has a fairly good prognosis with a 20 percent mortality rate (Devilard E, Bertucci F, Trempat P, et al. Oncogene. 2002; 21(19):3095-102). Diagnosis of this disease still relies on the observance of a particular type of cell morphology. The expression pattern of genes selected for inclusion in this set will allow diagnosis without the need for microscopy (Devilard E, Bertucci F, Trempat P, et al. Oncogene. 2002; 21(19):3095-102; Kuppers R, Klein U, Schwering I, et al. J Clin Invest. 2003; 111(4):529-37; Thorns C, Gaiser T, Lange K, et al. Pathol Int. 2002; 52(9):578-85).

Genes specific for HL were selected by mining public databases. The genes are listed in Table 8 and include genes in the following categories.

SIGNATURE Hodgkin's lymphoma is characterized by the presence of Reed-Sternberg cells. The genes selected for this section are genes that have been compared to various other types of lymphoma and have been found to be specific to Reed Sternberg cells and thus to Hodgkin's lymphoma (Kuppers R, Klein U, Schwering I, et al. J Clin Invest. 2003; 111(4):529-37).

SURVIVAL Devilard et al., related patient survival to a number of genes, all of which have been included in this set (Devilard E, Bertucci F, Trempat P, et al. Oncogene. 2002; 21(19):3095-102).

HL vs. ALCL This section distinguishes HL from a similar non-Hodgkin's lymphoma, ALCL (Thorns C, Gaiser T, Lange K, et al. Pathol Int. 2002; 52(9):578-85).

Example 6 Selection of Genes for an HCP Set Specific for ALCL

Anaplastic Large Cell Lymphoma is of T-cell origin and is a disease observed primarily amongst children (Villalva et al., Br J Haematol. 2002; 118(3):791-8). The majority of ALCLs bear a translocation at t(2;5)(p23;q35) that involve both the nucleophosmin (NPM) and anaplastic lymphoma kinase (ALK) genes. A number of diagnostic markers have also been discovered (Thorns C, Gaiser T, Lange K, et al. Pathol Int. 2002; 52(9):578-85; Villalva C, Trempat P, Greenland C, et al. Br J Haematol. 2002; 118(3):791-8; Wellmann A, Thieblemont C, Pittaluga S, et al. Blood. 2000 Jul. 15; 96(2):398-404; Nishikori M, Maesako Y, Ueda C, et al. Blood. 2003; 101(7):2789-96).

Genes specific for ALCL were selected by mining public databases. The genes are listed in Table 4 and include genes in the following categories.

ALCL vs. HL These genes distinguish HL from a similar non-Hodgkin's lymphoma, ALCL (Thorns C, Gaiser T, Lange K, et al. Pathol Int. 2002; 52(9):578-85).

ALK+ vs. ALK− These genes make a distinction between ALK bearing ALCLs from ALCL lacking samples (Villalva C, Trempat P, Greenland C, et al. Br J Haematol. 2002; 118(3):791-8).

Example 7 Design and Selection of Nucleotide Sequences Suitable for the Preparation of Polynucleotide Probes from an HCP Set

Nucleotide sequences suitable for the preparation of polynucleotide probes from an HCP set were selected based on the following criteria. The sequences selected were based on regions of the target gene in the HCP set that were 30 or 50 nucleotides in length, and had between 25 and 75% G+C content. The sequences were additionally selected such that self-complementary interactions were minimized. Nucleotide sequences thus selected that can be used for preparation of polynucleotide probes are found in Tables 25-28.

Example 8 Selection of Polynucleotide Probes for Preparation of a Small 50Mer Nucleic Acid Array

234 50mer polynucleotide probes were selected for the preparation of a small array for profiling lymphoma. Polynucleotide probes to be used in the preparation of this array were selected as described in example 7, and were designed to be 50 nucleotides in length. The nucleotide sequences of the polynucleotide probes selected for the preparation of this array are listed in Table 25.

Example 9 Selection of Polynucleotide Probes for Preparation of a Small 30Mer Nucleic Acid Array

248 30mer polynucleotide probes were selected for the preparation of a small array for profiling lymphoma. Polynucleotide probes to be used in the preparation of this array were selected as described in example 7, and were designed to be 30 nucleotides in length. The nucleotide sequences of the polynucleotide probes selected for the preparation of this array are listed in Table 26.

Example 10 Selection of Sequences for/Preparation of a Large 50Mer Nucleic Acid Array

971 50mer polynucleotide probes were selected for the preparation of a large array for profiling lymphoma. Polynucleotide probes to be used in the preparation of this array were selected as described in example 7, and were designed to be 50 nucleotides in length. Other polynucleotide probes corresponding to genes diagnostic of lymphoma on a general level were designed and selected according to methods known in the art. All polynucleotide probe sequences chosen for the large 50mer nucleic acid array are listed in Table 27.

Example 11 Selection of Sequences for/Preparation of a Large 30Mer Nucleic Acid Array

971 30mer polynucleotide probes were selected for the preparation of a large array for profiling lymphoma. Polynucleotide probes to be used in the preparation of this array were selected as described in example 7, and were designed to be 30 nucleotides in length. Other polynucleotide probes corresponding to genes diagnostic of lymphoma on a general level were designed and selected according to methods known in the art. All of the polynucleotide probe sequences chosen for the large 50mer nucleic acid array are listed in Table 28.

Example 12 Preparation of a Nucleic Acid Array

Small or large nucleic acid arrays can be prepared using the similar protocol.

A small 50mer nucleic acid array was prepared using UltraGAPS™ slides (Corning Life Sciences) as follows. Oligonucleotide probes with the sequences as set forth in Table 25 were synthesized and purified according to standard methods and were spotted in duplicate onto the slides at a concentration of 0.50 mg/mL using Corning's Pronto!™ Universal Spotting Solution. The slides were then incubated in a dessicator for 24-48 hours. Probes were immobilized onto the GAPS-coated surface of the slide by UV cross-linking.

Example 13 Preparation of Test Samples

A test sample, either a tissue or blood sample, obtained from a patient having, suspected of having, or suspected of being at risk for a hematological cancer can be prepared for use with a hematological cancer profiling array as follows.

RNA Isolation (with Qiagen RNeasy Kit, Boom et al., 1990)

1) Approximately 20-30 mg tissue is placed in liquid nitrogen and ground thoroughly using a mortar and pestle. The ground powder and liquid nitrogen are poured into a cooled 2 ml microfuge tube. The liquid nitrogen is allowed to evaporate off without letting the samples thaw out. Approximately 600 μl of buffer RLT are added in order to disrupt the cells.

2) Following the disruption of the cells by buffer RLT containing β-ME and guanidine thiocyanate, the cells are homogenized by passage through a 20 gauge needle.

3) The tissue lysate is spun for 3 min at maximum speed in a microcentrifuge. The supernatant is carefully transferred to a new microcentrifuge tube by pipetting. Only the supernatant (lysate) is used in subsequent steps.

4) Approximately 600 μl of 70% ethanol to the homogenized lysate is added and, mixed well by pipetting. It is not centrifuged as it would cause precipitation and decrease in RNA yield.

5) Up to approximately 700 μl of the sample, including any precipitate that may have formed, is added to an RNeasy mini column placed in a 2 ml collection tube (supplied in the kit). The column is centrifuged for 15 s at ≧8000×g (≧10,000 rpm) and flow through is discarded. The collection tube is reused in step 6.

6) Approximately 700 μl Buffer RW1 is then added to the RNeasy column and centrifuged for 15 s at ≧8000×g (≧10,000 rpm) to wash the column. Flow through is discarded alongside of the collection tube used for the first wash stage.

7) The RNeasy column is placed into a new 2 ml collection tube (supplied). Approximately 500 μl of Buffer RPE is pipetted onto the column and it is centrifuged for 15 s at ≧8000×g (≧10,000 rpm) to wash. Flow-through is again discarded.

8) A second volume of 500 μl Buffer RPE is added to the RNeasy column and it is centrifuged for about 2 min at ≧8000×g (≧10,000 rpm) to dry the RNeasy silica-gel membrane. As buffer RPE contains ethanol, special care is taken to ensure thorough drying and removal of all traces of ethanol.

9) The RNeasy column is relocated to a new 1.5 ml collection tube (supplied). An appropriate amount (30-50 μl, for example) of RNase-free water is gently pipetted directly onto the center of the RNeasy silica-gel membrane and centrifuged for 1 min at ≧8000×g (≧10,000 rpm) to elute.

10) The RNA content is then quantified by measuring the optical density of a 100× dilution and applying the following formula from Beer's law:

A ₂₆₀·Dilution Factor·40=[RNA] in μg/1 ml

11) The RNA is then qualitatively assessed by denaturing agarose gel electrophoresis with ethidium bromide staining according to methods known in the art.

RNA Labeling (Modified Eberwine Process, Van Gelder et al., 1990)

1) Synthesis of First Strand cDNA

1.1 Prepare working solution of Bacterial Control mRNAs

1.2 Prepare each total RNA sample for manual target preparation (exemplary proportions are given below):

0.2-2 μg total RNA X μl working solution of bacteria control mRNAs (1 μl per 1 μg input total RNA, dilute as required) 1 μl T7 oligo (dT) primer Y μl nuclease-free water 12 μl Final Volume

1.3 Incubate approximately 10 min in 70° C. water bath; immediately place tube on ice until cool.

1.4 Centrifuge for 5 s to collect sample at the bottom of the tube; return tube to ice.

1.5 Keep the tube on ice and add the following reagents to the total volume (12 μl, in the above example) of total RNA/control mRNA/primer mix from above:

2 μl 10x first strand buffer 4 μl 5 mM dNTP mix 1 μl RNase inhibitor 1 μl reverse transcriptase 20 μl  Final volume

1.6 Incubate 2 h in a 42° C. water bath

1.7 Centrifuge for 5 s to collect sample at the bottom of the tube.

2) Synthesis of Second Strand cDNA

2.1 Prepare the following second strand cDNA synthesis mix for each sample from step 2:

Approximately 20 μl First strand cDNA reaction from step 1.7 63 μl Nuclease-free water 10 μl 10x second strand buffer 4 μl 5 mM dNTP mix 2 μl DNA polymerase mix 1 μl RNaseH 100 μl Final Volume

2.2 Gently flick tube to mix then centrifuge at ≧10 000×g to combine the reactants. Incubate 2 h at 16° C. in an incubator.

2.3 Centrifuge 5 s at maximum speed to collect sample at the bottom of the tube. Mix gently and place the tube on ice. Proceed directly to step 4 or store overnight at −20° C.

3) Purification of Double-Stranded cDNA (Qiagen, Boom et al., 1990)

3.1 Add approximately 500 μl buffer PB to the cDNA from step 2.3 and mix gently by pipetting up and down.

3.2 Place a QIAquick spin column into a 2 ml collection tube.

3.3 Transfer the cDNA buffer PB solution to the QIAquick spin column.

3.4 Centrifuge the spin column at ≧10 000×g for 30-60 s.

3.5 Discard the flow-through. To wash the column, add 700 μl buffer PE to the column and centrifuge at ≧10 000×g.

3.6 Discard the flow-through. To dry the column, place the QIAquick column into a new 2-ml collection tube and centrifuge at ≧10 000×g for 1 min.

3.7 Place the QIAquick column into a clean 1.5-ml microcentrifuge tube.

3.8 To elute the cDNA, add approximately 30 μl of EB buffer to the center of the QIAquick membrane. Let the column stand for 1 min, then centrifuge for 1 min at ≧10 000×g. Repeat once to generate a total of approximately 60 μl eluate. 3.9 Dry the cDNA solution in a SpeedVac concentrator under medium heat (approximately 1 h).

4) Synthesis of cRNA by In Vitro Transcription (IVT) Using T7 RNA Polymerase (All Measurements are Approximate)

4.1 Make a resuspension solution by placing the following components in a new RNase-free microcentrifuge tube (approximate volumes):

9.5 μl Nuclease-free water 4.0 μl 10X T7 reaction buffer 13.5 μl  Total Volume

4.2 Resuspend each cDNA pellet from step 3.9 with 13.5 μl of the above resuspension solution. Pipette up and down to ensure resuspension of the pellet(s).

4.3 Make the IVT mixture by adding the following in another RNase-free microcentrifuge tube (volumes are approximate):

4.0 μL T7 ATP solution 4.0 μL T7 GTP solution 4.0 μL T7 CTP solution 3.0 μL T7 UTP solution 7.5 μl mM biotin-11-UTP 4.0 μl 10X T7 enzyme mix 26.5 μl  Final Volume

4.4 Mix the components of the IVT mixture by briefly vortexing the tube. Centrifuge the tube for 5 s at ≧10 000×g. Transfer this reaction mixture (26.5 μl) into the tube of resuspended cDNA from step 4.2, and gently pipette up and down to ensure complete mixing.

4.5 Incubate the reaction for 14 h in an air incubator at 37° C. (Water baths and open heat blocks are not recommended due to condensation on the lid of the microcentrifuge tube)

5) Recovery of Biotin Labelled cRNA (Qiagen, Boom et al., 1990) (All Measurements are Approximate)

5.1 Prepare working solutions of the RLT and RPE buffers.

5.2 Adjust the IVT reaction volume to approximately 100 μl by adding an appropriate volume (for example, 60 μl) of nuclease-free water.

5.3 Add 350 μl buffer RLT to the sample and mix thoroughly by pipetting up and down.

5.4 Add 250 μl of 100% ethanol to the reaction sample and mix well by pipetting up and down. Do not centrifuge.

5.5 Apply the sample (700 μl) to an RNeasy spin column in a collection tube. Centrifuge for 15 s at ≧8000×g.

5.6 Transfer the RNeasy column into a new 2-ml collection tube (supplied). Add 500 μl of buffer RPE to column and centrifuge for 15 s at ≧8000×g. Discard flow-through and reuse the collection tube. Repeat this wash step once.

5.7 Place the RNeasy spin column into a new 2 μl collection tube and centrifuge at ≧8000×g for 2 min to dry the membrane.

5.8 Transfer the RNeasy column into a new 1.5-ml collection tube (supplied), and pipette 50 μl of nuclease-free water directly onto the RNeasy membrane without touching the membrane.

5.9 Incubate at ambient temperature for 10 minutes. Elute the cRNA by centrifugation at ≧8000×g for 1 min. Do not remove the column.

5.10 Pipette another 50 μl of nuclease-free water directly onto the same RNeasy membrane.

5.11 Incubate at ambient temperature for 10 min. Elute the cRNA (into the same tube used in step 5.8) by centrifugation at ≧8000×g for 1 min.

5.12 Remove the column. Mix the solution by flicking the tube.

5.13 Store the cRNA at −70° C.

6) Assessment of cRNA Concentration, Yield and Quality

The UV spectrophotometric quantitation method is described. Other methods of quality analysis involve either denaturing gel-electrophoresis or Agilent 2100 Bioanalyzer.

6.1 Prepare a appropriate dilution (for example, 1:50) for each sample of cRNA in nuclease-free water:

2 μl cRNA 98 μl nuclease-free water 100 μl Final Volume

6.2 Vortex the mixture and centrifuge for 5 s at ≧10 000×g to collect all fluid at the bottom of the tube.

6.3 Transfer the cRNA dilution to a 100-μl quartz cuvette (1-cm pathlength) and measure UV absorbance at 260 nm. If the A₂₆₀ values are less than 0.15, prepare a 1:20 dilution of the cRNA and measure its UV absorbance at 260 nm. For accurate concentration determination, the dilution must yield an A260 in the linear range of approximately 0.15-0.95. If the initial reading with 1:50 dilution is not in the linear range, prepare another sample with the appropriate dilution change.

6.4 Calculate the cRNA concentration:

1A ₂₆₀ unit=40 μg/ml (1-cm pathlength cuvette):

Concentration in μg/μl=A ₂₆₀×dilution factor×40 μg/ml×0.001 ml/μl

6.5 The A₂₆₀:A₂₈₀ ratio is sensitive to pH. Thus, to accurately determine the purity of the sample, it can be buffered. Transfer the diluted cRNA from the cuvette to a new microcentrifuge tube and add 11.1 μl of 0.1 M Tris-HCl, pH 7.6. Vortex the mixture.

6.6 Transfer the Tris-diluted cRNA (˜100 μl) to a quartz cuvette and measure UV absorbance at 260 nm and 280 nm. The A₂₆₀:A₂₈₀ ratio is a measure of sample purity and should be within 1.8-2.1.

1.1 For each array to be loaded, bring approximately 10 μg of cRNA (from step 6.6) to a final volume of about 20 μl with nuclease-free water in a thin walled microcentrifuge tube.

1.2 Add 5 μl of 5× buffer for each microarray. Place tube in a thermal cycler and heat for 20 min at 94° C. using the heated lid feature.

1.3 Cool to 0° C. in the thermal cycler for at least 5 min.

Hybridization and Washing:

1) Fragmentation of cRNA in Preparation for Hybridisation to the Array

1.1 For each microarray to be loaded, bring 10 μg of cRNA (from step 6.6) to a final volume of 20 μl with nuclease-free water in a thin walled microcentrifuge tube.

1.2 Add 5 μl of 5× fragmentation buffer for each microarray. Place tube in a thermal cycler and heat for 20 min at 94° C. using the heated lid feature.

1.3 Cool to 0° C. in the thermal cycler for at least 5 min.

2) Preparation of Hybridization Reaction Mixtures

2.1 Set the temperature of the shaker-incubator to 37° C. for hybridization. Assemble microarray tray posts from the CodeLink Shaker Kit onto the incubator platform.

2.2 For each microarray to be processed, prepare 260 μl of hybridization solution containing 10 μg of fragmented target cRNA in a 1.5-microcentrifuge tube:

78 μl hybridization buffer component A 130 μl hybridization buffer component B 27 μl nuclease-free water 25 μl fragmented cRNA (from section 1) 260 μl total volume

2.3 Vortex the solution for 5 s at maximum speed. Incubate the hybridization solution at 90° C. for 5 min to denature the cRNA.

2.4 Cool the tube(s) on ice for at least 5 and no more than 30 min. Load all microarrays within 30 min of denaturing the cRNA.

3) Loading of Reaction Mixtures into Microarray Chambers

3.1 Set a slide shaker tray on a level surface. Place the microarrays into the shaker tray with the input/output ports facing up. Load microarrays in sets of 12 or less.

3.2 Vortex the hybridization reaction mixture for 5 s at maximum speed. Centrifuge briefly to gather the liquid at the bottom of the tube. Place the tube back on ice.

3.3 For each microarray, draw 250 μl into a 1-ml wide-bore pipette tip and slowly inject the entire sample into the chamber without using the blowout feature of the pipettor. Discard any excess target mix remaining in the pipette tip. Aspirate any excess fluid surrounding the outside of the port with a pipette tip and discard. Use a lint-free wipe to blot residual fluid from around the port, taking care not to actually touch the port.

3.4 After loading up to 12 microarrays, seal the Flex Chamber ports using sealing strips and port sealing tool. Do not touch the Flex Chamber or directly depress the port.

4) Hybridization

4.1 Align the 12-slide shaker tray notches with the front and back posts fixed to the shaker-incubator platform to place the loaded shaker tray into the shaker-incubator. The Flex Chamber should be facing up.

4.2 Set the shaker speed to 300 rpm and incubate slides for 18-24 h at 37° C. It is critical that arrays used in any form of comparison are hybridized for the same amount of time within the given range.

4.3 To prepare for the next step, fill a large reagent reservoir with 240 ml of filtered 0.75×TNT buffer. Cover the reservoir and incubate in a 46° C. water bath overnight.

5) Post-Hybridization Wash

5.1 Fill each slot in the medium reagent reservoir with 13 ml of filtered 0.75×TNT. Place the microarray rack into the reservoir. Leave at ambient temperature.

5.2 Remove the 12-slide shaker tray from the shaker incubator, and place on a level surface at ambient temperature. Process only 12 slides at a time per person. Leave the trays in the shaker until ready to process.

5.3 Place the first microarray to be processed into the Flex Chamber removal tool.

5.4 Remove the Flex Chamber by lifting the tab and slowly pulling it back at a 60° angle without creasing the Flex Chamber.

5.5 Place the microarray into a slot of the microarray rack, which was placed to a medium reagent reservoir containing 0.75×TNT in step 5.1. Use the microarray position tool, tooth-side down, to ensure the microarrays are properly seated.

5.6 To avoid potential cross-contamination, rinse the surface of the Flex Chamber removal tool with approximately 5 ml of ambient temperature 0.75×TNT buffer dispensed from a squirt bottle. Keep the medium reagent reservoir at ambient temperature until all microarrays have been processed.

5.7 Repeat steps 5.3-5.6 for each hybridized microarray.

5.8 Transfer the microarray rack with microarrays from the medium reagent reservoir into the pre-warmed, 0.75×TNT-filled large reagent reservoir from step 4.3. Replace the lid on the large reagent reservoir and then on the water bath. Incubate at 46° C. for exactly 1 h; longer incubation time may significantly reduce signal intensities.

Detection with Streptavidin-Dye Conjugate

6.1 Fill each slot in the small reagent reservoir with 3.4 ml of Cy5-Streptavidin working solution. Leave at ambient temperature. Cover the small reagent reservoir with its lid to prevent photobleaching of the fluorophore by ambient light.

6.2 Remove the microarray rack with microarrays from the large reagent reservoir at 46° C., and place into the small reagent reservoir containing the Cy5-Streptavidin working solution. Cover with the lid and incubate microarrays at ambient temperature for 30 min.

6.3 During incubation, prepare for the wash steps by filling four large reagent reservoirs each with 240 ml of ambient temperature 1×TNT buffer.

6.4 After the 30 min incubation, remove the microarray rack with microarrays from the staining solution and place into one large reagent reservoir containing 1×TNT buffer (prepared in 6.3). Do not drain the solution from the microarrays. Incubate at ambient temperature for 5 min, covered from light.

6.5 Remove the microarray rack from the first large reagent reservoir with 1×TNT buffer and place into a second large reagent reservoir containing 1×TNT buffer. Again, do not attempt to drain the solution from the microarrays. Incubate at ambient temperature for 5 min, covered from light. Repeat this step with two additional large reagent reservoirs containing fresh 1×TNT buffer for a third and fourth wash.

6.6 During the third wash, thoroughly rinse a large reagent reservoir with distilled water and dry it. Completely fill this reservoir with the final rinse 0.1×SSC/0.05% Tween 20 solution.

6.7 Transfer the microarray rack into the large reagent reservoir completely filled with 0.1×SSC/0.05% Tween 20 at ambient temperature. Incubate the slides for 30 seconds while continually agitating mildly up and down.

6.8 Remove the microarray rack from the large reagent reservoir and blot the bottom edge of the microarrays briefly on an absorbent paper towel. Place the microarray rack in a clean, dry medium reagent reservoir. Dry the microarrays by centrifugation in the Qiagen Sigma 4-15 C centrifuge with corresponding bucket rotor (2×96-well plate) or similar system using following settings:

Speed: 2000 rpm (644×g) Acceleration: 9 Deceleration: 9 Time: 3 min

6.9 Use the microarray removal tool to easily remove the microarrays from the microarray rack, and place the dry microarrays into a light-protected slide box until they are scanned. Microarrays should be scanned within two days of assay completion.

6.10 Repeatedly rinse all reservoirs with deionized water to clean, and invert to dry.

6.11 Wash the rack with Alconox™ soap, scrubbing between the rails with a pipe cleaner style brush. Rinse thoroughly with deionized water to remove residual soap. Air-dry the rack.

7) Microarray Scanning and Analysis

7.1 Turn the scanner on 15 min prior to use.

7.2 Slide the cover to the left to expose the slide holder.

7.3 Lift the latch of the slide holder and lift the upper clip.

7.4 Wearing latex gloves, load the microarray into the tray with the label side down and closest to the front of the scanner.

7.5 Pull the clip on the left of the slide out and let the microarray fall into place. Release the clip to put pressure against the microarray.

7.6 Grab microarray by the edges and move the microarray toward you.

7.7 Lower upper clip and press down on the latch until it clicks.

7.8 Slide the cover to the right to cover the slide holder.

7.9 Open the array analysis software program and select the following settings:

Wavelength: 635 nm

PMT voltage: 600 V Laser power: 100% Pixel size: 10 μm Focus position: 0 μm

7.10 The hematological cancer array can be scanned according to the standard protocol.

7.11 Enter the microarray serial number and click Next. The Experiment and Scan Information interface is displayed.

7.12 Type in the project name, experiment name, and sample name. The username is automatically captured. When opening this interface for the first time, a message box may ask whether to allow an ActiveX interaction to proceed.

7.13 Select a setting (.gps) file. If a settings file was previously selected, the name and path are displayed under Current Settings File. To select a new file, click Browse under Select New Settings File. The values for project name, experiment name, user name, and settings file that were entered for a previous microarray are retained but may be changed.

7.14 In the Load and Scan Slide screen, the standard TIF file name for the current microarray is displayed. If desired, the name may be changed.

7.15 Click Browse to select the image path or the location where the image files will be stored. If a Security Alert message box is displayed.

7.16 Click Scan Slide. The Image tab will display, and the instrument will perform the scan.

7.17 When complete, the view will return to the Report tab.

7.18 Click Save Image to save the scanned image at the appropriate file location.

7.19 Slide the cover to the left and remove the microarray.

7.20 To scan the next microarray, click New Slide and enter the serial number for the next microarray. The setting information previously entered will be retained.

7.21 Analyze the image from each microarray using the software.

Example 14 Selection of Additional Genes for HCP Sets Relating to Lymphoma or Leukemia

Genes whose expression pattern is indicative of one or more features of a hematological cancer selected from the group of lymphoma and leukemia were selected for inclusion into HCP sets as follows. Initial gene selection was carried out by consulting numerous publications to identify genes that have been shown to hold diagnostic or prognostic potential for lymphoma and/or leukemia. A list of publications consulted is found below:

-   Staudt L M. Molecular diagnosis of the hematologic cancers. N Engl J     Med. 2003; 348(18): 1777-85. [Erratum: N Engl J Med. 2003;     348(25):2588.] -   Diehl V, Thomas R K, Re D. Part II: Hodgkin's lymphoma—diagnosis and     treatment. Lancet Oncol. 2004; 5(1):19-26. -   Soukup J, Krskova L, Mrhalova M, et al. Large-cell diffuse B-cell     lymphoma: heterogenous origin and prognosis from the aspect of     modern diagnosis. Cas Lek Cesk. 2003; 142(7):417-2 -   Guermazi A, Brice P, Hennequin C, et al. Lymphography: an old     technique retains its usefulness. Radiographics. 2003;     23(6):1541-58; discussion 1559-60. -   Alizadeh A A, Eisen M B, Davis R E et al. Distinct types of diffuse     large B-cell lymphoma identified by gene expression profiling.     Nature. 2000; 403(6769):503-11. -   Harris N L, Jaffe E S, Diebold J et al. Lymphoma classification—from     controversy to consensus: the R.E.A.L. and WHO Classification of     lymphoid neoplasms. Ann Oncol. 2000; 11 Suppl 1:3-10. -   Rosenwald A, Wright G, Chan W C et al. The use of molecular     profiling to predict survival after chemotherapy for diffuse     large-B-cell lymphoma. N Engl J Med. 2002; 346(25): 1937-47. -   Rosenwald A, Wright G, Leroy K. et al. Molecular diagnosis of     primary mediastinal B cell lymphoma identifies a clinically     favorable subgroup of diffuse large B cell lymphoma related to     Hodgkin lymphoma. J Exp Med. 2003; 198(6):851-62. -   Wright G, Tan B, Rosenwald A, et al. A gene expression-based method     to diagnose clinically distinct subgroups of diffuse large B cell     lymphoma Proc Natl Acad Sci USA. 2003; 100(17):9991-6 -   Savage K J, Monti S, Kutok J L, et al. The molecular signature of     mediastinal large B-cell lymphoma differs from that of other diffuse     large B-cell lymphomas and shares features with classical Hodgkin     lymphoma. Blood. 2003; 102(12):3871-9 -   Shipp M A, Ross K N, Tamayo P et al. Diffuse large B-cell lymphoma     outcome prediction by gene-expression profiling and supervised     machine learning. Nat Med. 2002 January; 8(1):68-74. -   Pan Z, Shen Y, Du C, et al. Two newly characterized germinal center     B-cell-associated genes, GCET1 and GCET2, have differential     expression in normal and neoplastic B cells. Am J Pathol. 2003;     163(1):135-44. -   Nishiu M, Yanagawa R, Nakatsuka S, et al. Microarray analysis of     gene-expression profiles in diffuse large B-cell lymphoma:     identification of genes related to disease progression. Jpn J Cancer     Res. 2002; 93(8):894-901. -   Lossos I S, Alizadeh A A, Diehn M, et al. Transformation of     follicular lymphoma to diffuse large-cell lymphoma: alternative     patterns with increased or decreased expression of c-myc and its     regulated genes. Proc Natl Acad Sci USA. 2002; 99(13):8886-91. -   de Vos S, Hofmann W K, Grogan T M, et al. Gene expression profile of     serial samples of transformed B-cell lymphomas. Lab Invest. 2003;     83(2):271-85. -   Kossakowska A E, Urbanski S J, Watson A, et al. Patterns of     expression of metalloproteinases and their inhibitors in human     malignant lymphomas. Oncol Res. 1993; 5(1):19-28. -   Husson H, Carideo E G, Neuberg D, et al. Gene expression profiling     of follicular lymphoma and normal germinal center B cells using cDNA     arrays. Blood. 2002; 99(1):282-9. -   Lestou V S, Gascoyne R D, Sehn L, et al. Multicolour fluorescence in     situ hybridization analysis of t(14;18)-positive follicular lymphoma     and correlation with gene expression data and clinical outcome. Br J     Haematol. 2003; 122(5):745-59. -   Maesako Y, Uchiyama T, Ohno H. Comparison of gene expression     profiles of lymphoma cell lines from transformed follicular     lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell     lymphoma. Cancer Sci. 2003; 94(9):774-81. -   Ghia P, Boussiotis V A, Schultze J L, et al. Unbalanced expression     of bcl-2 family proteins in follicular lymphoma: contribution of     CD40 signaling in promoting survival. Blood. 1998; 91(1):244-51. -   Akasaka T, Lossos I S, Levy R. BCL6 gene translocation in follicular     lymphoma: a harbinger of eventual transformation to diffuse     aggressive lymphoma. Blood. 2003; 102(4):1443-8. -   Elenitoba-Johnson K S, Gascoyne R D, Lim M S, et al. Homozygous     deletions at chromosome 9p21 involving p16 and p15 are associated     with histologic progression in follicle center lymphoma. Blood.     1998; 91(12):4677-85. -   Rosenwald A, Alizadeh A A, Widhopf G, et al. Relation of gene     expression phenotype to immunoglobulin mutation genotype in B cell     chronic lymphocytic leukemia. J Exp Med. 2001; 194(11):1639-47. -   Hamblin T J, Davis Z, Gardiner A, et al. Unmutated Ig V(H) genes are     associated with a more aggressive form of chronic lymphocytic     leukemia. Blood. 1999; 94(6):1848-54. -   Damle R N, Wasil T, Fais F, et al. Ig V gene mutation status and     CD38 expression as novel prognostic indicators in chronic     lymphocytic leukemia. Blood. 1999; 94(6): 1840-7 -   Wiestner A, Rosenwald A, Barry T S, et al. ZAP-70 expression     identifies a chronic lymphocytic leukemia subtype with unmutated     immunoglobulin genes, inferior clinical outcome, and distinct gene     expression profile. Blood. 2003; 101(12):4944-51. -   Nagy B, Ferrer A, Larramendy M L, et al. Lymphotoxin beta expression     is high in chronic lymphocytic leukemia but low in small lymphocytic     lymphoma: a quantitative real-time reverse transcriptase polymerase     chain reaction analysis. Haematologica. 2003; 88(6):654-8. -   Cro L, Guffanti A, Colombi M, et al. Diagnostic role and prognostic     significance of a simplified immunophenotypic classification of     mature B cell chronic lymphoid leukemias. Leukemia. 2003;     17(1):125-32. -   Thieblemont C, Chettab K, Felman P, et al. Identification and     validation of seven genes, as potential markers, for the     differential diagnosis of small B cell lymphomas (small lymphocytic     lymphoma, marginal zone B cell lymphoma and mantle cell lymphoma) by     cDNA macroarrays analysis. Leukemia. 2002; 16(11):2326-9 -   Korz C, Pscherer A, Benner A, et al. Evidence for distinct     pathomechanisms in B-cell chronic lymphocytic leukemia and mantle     cell lymphoma by quantitative expression analysis of cell cycle and     apoptosis-associated genes. Blood. 2002; 99(12):4554-61. -   Robetorye R S, Bohling S D, Morgan J W, et al. Microarray analysis     of B-cell lymphoma cell lines with the t(14;18). J Mol Diagn. 2002;     4(3):123-36. -   Martinez N, Camacho F I, Algara P, et al. The molecular signature of     mantle cell lymphoma reveals multiple signals favoring cell     survival. Cancer Res. 2003; 63(23):8226-32. -   Kobayashi T, Yamaguchi M, Kim S, et al. Microarray reveals     differences in both tumors and vascular specific gene expression in     de novo CD5+ and CD5− diffuse large B-cell lymphomas. Cancer Res.     2003; 63(1):60-6. -   Devilard E, Bertucci F, Trempat P, et al. Gene expression profiling     defines molecular subtypes of classical Hodgkin's disease. Oncogene.     2002; 21(19):3095-102. -   Kuppers R, Klein U, Schwering I, et al. Identification of Hodgkin     and Reed-Sternberg cell-specific genes by gene expression profiling.     J Clin Invest. 2003; 111(4):529-37. -   Thorns C, Gaiser T, Lange K, et al. cDNA arrays: gene expression     profiles of Hodgkin's disease and anaplastic large cell lymphoma     cell lines. Pathol Int. 2002; 52(9):578-85. -   Villalva C, Trempat P, Greenland C, et al. 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Points were awarded to genes of interest based on the number of independent researchers who found modulations within lymphoma and/or leukemia, as well as the number of different methods used. For example, four scientists found CD22 to be differentially expressed between subtypes using three different techniques (microarray analysis, FISH and PCR); therefore CD22 was assigned 4 points for independent research and 3 points for different methods for a total of 7 points. Another gene, CD3D, was shown to be differentially expressed by three researchers; however they all used microarray analysis as their method. Consequently, CD3D was assigned 3 points for independent research but only one for different methods, resulting in a total score of 4 points. The identified genes were ranked and the 1154 with the highest point values were selected for inclusion in one or more HCP sets. A list of these genes is shown in Table 1.

Example 15 Identification of Polynucleotide Probes for Detecting Expression Levels of Genes in HCP Sets

Nucleotide sequences suitable for the preparation of polynucleotide probes for detecting expression levels of genes in HCP sets were determined as described in Example 7. The nucleotide sequences of the polynucleotide probes selected in this manner are shown in Table 20.

Example 16 Preparation of an Hematological Cancer Profiling (HCP) Array

The HCP array was manufactured using CodeLink technology, by GE Healthcare (USA). Briefly, the probes are manufactured and then tethered onto the array glass slide containing CodeLink's proprietary 3-D aqueous gel. This tethering step was performed in a class 1000 clean room to avoid contamination of the array slide surface. Manufactured array slides were then subjected to quality control before usage.

The HCP array slide contained 1192 probes targeting human mRNA sequences and 62 control (30 positive control and 32 negative control) probes which target bacterial sequences that are not found in humans. These control target genes are shown in Tables 29 and 30.

Example 17 Preparation of Test Samples from Lymphoma and Leukemia Tissues for Profiling Using an HCP Array

Test samples from 23 human lymphoma tissues, 2 leukemia tissues, and 2 control tissues were prepared. Lymphoma samples were taken from lymph nodes, leukemia samples were prepared from blood samples, and control tissues consisted of human white blood cells. The 23 lymphoma samples consisted of 5 DLBCL, 4 FL, 4 HL, 4 MCL, 2 MZL, 2 SLL and 2 peripheral TCL samples as shown in Table 42. Both the leukemia RNA samples were from CLL patients, and the 2 cell lines used were Jurkat (T-ALL) and K-562 (AML), as shown in Table 43.

TABLE 42 Lymphoma samples Lymphoma Location or Cell type DLBCL-1 Stomach DLBCL-2 Lymph node DLBCL-3 Spleen DLBCL-4 Spleen DLBCL-5 Groin FL-1 Lymph node FL-3 Small intestine FL-4 Lymph node FL-5 Lymph node HL-1 Lymph node HL-2 Lymph node HL-3 Lymph node HL-4 Lymph node MCL-1 Lymph node MCL-2 Ileum MCL-3 Lacrimal gland MCL-4 Spleen MZL-2 Lymph node MZL-4 Lymph node SLL-1 Lymph node SLL-3 Lymph node TCL-1 Lymph node TCL-2 Testis

TABLE 43 Leukemia samples Patient sample or Leukemia Cell line CLL-1 Patient sample CLL-2 Patient sample AML K-562 (Cell line) T-ALL Jurkat (Cell line)

Total RNA samples from leukemia, and control tissues were prepared using the Paxgene Blood RNA kit (Qiagen), according to the protocol supplied with the kit. Briefly, total RNA was isolated form 2.5 mL of blood. First, blood RNA tubes were thawed and incubated at room temperature for 2 hours. Next, the tubes were spun for 10 minutes and the supernatant removed. 5 mL of RNase-free water was added, followed by vortexing to resuspend pellet. The RNA tube was again spun for 10 minutes and supernatant removed. Buffers BR1 (360 μL), BR2 (300 μL) and 40 μL Proteinase K were added to the sample, vortexed and incubated for 10 min in 55° C. shaker-incubator. After incubation, the sample was spun for 3 min and supernatant was transferred to a new 1.5 mL tube. 350 μL ethanol was added, and the solution was loaded onto PAXgene column. Column was centrifuged for 1 minute and flow-through discarded. Buffers (700 μL BR3 and 2×500 μL BR4, respectively) were added to the column, spun and flow-through discarded each time. Column was transferred to new 1.5 mL tube, 40 μL Buffer BR5 added and column was spun for 1 minute. Another 40 μL Buffer BR5 was added to column and spun for 1 min. Eluate was incubated for 5 min at 65° C., chilled on ice and stored at −70° C.

Lymphoma samples were prepared from lymph node samples using the Qiagen RNeasy kit according to the protocol supplied with the kit.

Poly-A mRNA was isolated from the cell lines using the Ambion Poly(A)Purist Kit for mRNA isolation, according to the protocol supplied with the kit. Sample RNA quality was assessed using an Agilent 2100 Bioanalyzer.

Sample RNA quality from all samples was assessed using an Agilent 2100 Bioanalyzer.

Biotin-labeled cRNA was prepared from the RNA samples as follows. cRNA synthesis was performed essentially as described by Shippy et al. BMC Genomics. 2004 Sep. 2; 5(1):61. Briefly, cRNA was prepared by in vitro transcription using a single, labeled nucleotide, biotin-11-UTP in the IVT reaction at a concentration of 1.25 mM. Unlabeled UTP was present at 3.75 mM, while GTP, ATP, and CTP were at 5 mM. The mixture was incubated at 37° C. overnight for 14 hours. The labeled cRNA was then purified using an RNeasy® mini kit (Qiagen) according to the manufacturer's protocol. The concentration and quality of the cRNA were confirmed using an Agilent 2100 Bioanalyzer.

Example 18 Hybridization of Test Samples to HCP Array and Detection of Hybridization

Each sample was run in duplicate (and in some cases triplicate) on the HCP array. The replicates were compared to ensure the consistency of the array. Sample replicates were hybridized with the HCP array described in Example 16, using a method similar to that described by Davidson et al. Cancer Res. 2004 Sep. 15; 64(18):6797-6804. Briefly, the purified cRNA was fragmented in 5× fragmentation buffer at 94° C. for 20 minutes. 6 μg of fragmented cRNA in 60 μl of hybridization solution was added to each array chamber and incubated for 18 hours at 37° C., while shaking at 225 r.p.m. After hybridization, the arrays were washed in 0.75×TNT (0.1M Tris-Hcl, pH 7.6, 0.15M NaCl, 0.05% Tween 20) buffer at 46° C. for 1 hour followed by incubation with Cy5™-streptavidin at room temperature for 30 minutes in the dark. Arrays were then washed in 1×TNT four times for 5 minutes each followed by a rinse in 0.05% Tween 20/SSC buffer. The arrays were then dried by centrifugation, chamber units were removed and slides were kept in the dark until scanning.

Slides were scanned using the GenePix 4000B (Axon Instruments) and image analysis was carried out with the CodeLink Expression v4 software (Amersham Biosciences).

Example 19 Analysis of Data Generated from Hybridization of Lymphoma Test Samples to HCP Array

The gene expression profiles resulting from the hybridization of lymphoma test sample cRNA with the HCP array were analyzed using microarray analysis software to identify differentially expressed genes and establish distinct genetic profiles for lymphoma subtypes. Clustering algorithms were also employed.

Lymphoma and leukemia experiments were performed at different times and, therefore, were analyzed separately. The data analysis methods varied for the two data sets due to the differing sample sizes and subtype representation of the lymphoma and leukemia studies. The analysis of data generated from leukemia samples is described in Example 20.

Before performing analyses, expression values were normalized using the quantile normalization method so that the gene expression between samples could be compared. Technical replicates were merged by taking the average of expression values.

Lymphoma Data Analysis

To determine the unique gene signatures for each subtype, two methods were used to generate two independent lists. Both methods used the entire discovery gene list as shown in Table 1 as a starting point and imposed a two-fold differential expression limit; however, one list was compiled manually by evaluating differences in fold change relative to the control, while the other list was generated using statistical analyses to determine genes that were significantly differentially expressed between the subtypes. For each subtype, the two lists were compared and overlapped to produce a subtype-specific gene signature.

Genes that were common to all subtypes of lymphoma, either always overexpressed or always underexpressed vs. control, were removed from subtype signatures. These genes are listed in Table 31, and may be of interest when comparing subtypes to each other, however they do not aid in distinguishing subtypes in relation to the control.

The size of the gene signatures ranged from 33 genes for HL, to 159 genes for MZL (See Tables 32-38). Because they were based on fewer samples, the signatures for MZL, SLL and TCL are larger, yet less reliable than the other subtypes. The total number of genes that make up the seven lymphoma subtype-specific signatures was determined to be 296. These genes are shown in Table 2:

Signature genes for each lymphoma subtype are listed in Tables 32-38 and shown as hierarchical clustering images in FIGS. 1-7.

The 296 genes found to be differentially expressed between subtypes, relative to the control, were clustered using hierarchical clustering with average linkage using the Euclidian distance metrics, shown in FIG. 8. Differential gene expression is seen between lymphoma and controls as well as between the various lymphoma subtypes.

Results

The HCP array was able to detect genes in the lymphoma and control samples. Correlation coefficient and other statistical analyses revealed that sample replicates were highly similar to one another, demonstrating the consistency of the HCP array. Statistical analyses also revealed a high dissimilarity between the lymphoma and leukemia subtypes (see Example 20) and controls, indicating that the HCP array is able to detect differential expression profiles (see FIGS. 8 and 9). As well as distinguishing between “diseased” and “healthy” samples, the HCP array identified distinct gene expression profiles that were produced by the different lymphoma and subtypes. These profiles, seen in FIGS. 1-8, provide information useful for accurate diagnosis and risk assessment.

The HCP array identified unique gene expression profiles, referred to as signatures, for each of the lymphoma subtypes tested. The following genetic signatures distinguished specific subtypes, and are listed in relation to the expression level in control samples.

Diffuse Large B-Cell Lymphoma

Diffuse Large B-Cell Lymphoma (DLBCL) is the most common subtype of non-Hodgkin's lymphoma, accounting for 40% of annual NHL cases. DLBCL is an aggressive malignancy, with less than half of patients achieving remission. DLCBL signature genes are shown in Table 32

Follicular Lymphoma

Follicular lymphoma (FL) is an indolent or slow growing cancer that accounts for about 25% of all non-Hodgkin's lymphomas. Due to the slow onset of FL, many patients exhibit wide-spread disease by the time they are diagnosed. Another complication of FL is that it undergoes a transformation into a more aggressive form of DLBCL in 25-60% of patients. FL signature genes are shown in Table 33.

Hodgkin's Lymphoma

Hodgkin's Lymphoma (HL) has a fairly good prognosis, with a 20 percent mortality rate. HL is characterized by the presence of a particular type of cell morphology, known as Reed-Sternberg Cells. While HL is easier to distinguish than many subtypes, its similarity to T-Cell lymphomas, such as ALCL, still proves an obstacle to diagnosis. HL signature genes are shown in Table 34.

Mantle Cell Lymphoma

Mantle Cell Lymphoma (MCL) accounts for only 6% of NHL's but claims for a disproportionately larger number of lives because it is an aggressive, incurable disease. Due to delayed diagnosis, many patients already have bone marrow involvement by the time MCL is identified. Some patients succumb to MCL in under a year while others survive for longer; the median survival for MCL is 3 years. MCL signature genes are shown in Table 35.

Marginal Zone B-Cell Lymphoma

Marginal Zone B-Cell Lymphoma (MZL) is similar to MCL in appearance but progresses much more slowly. MZL can be difficult to detect, because, unlike many other lymphomas, it is not uncommon for marginal zone tumors to occur “extranodally” in areas outside the lymph nodes, such as the stomach, thyroid or bladder. MZL signature genes are shown in Table 36.

Small Lymphocytic Lymphoma

Small Lymphocytic Lymphoma (SLL) is closely related to B-Cell Chronic Lymphocytic Leukemia (B-CLL) and tends to follow a less severe disease course than many lymphomas. However, in approximately 15% of cases, SLL transforms into aggressive DLCBL. Recent research has shown the potential of gene expression profiling to help predict these deadly transformations. SLL signature genes are shown in Table 37.

T-Cell Lymphoma

T-Cell Lymphomas (TCL) account for only 15% of NHL, but tend to have a poor prognosis. TCL often strikes immuno-compromised individuals and is resistant to therapy. TCL signature genes are shown in Table 38.

The results of this study indicated that the above gene signatures can be used to distinguish between lymphoma subtypes thereby facilitating accurate diagnosis and timely treatment for patients.

The generated lymphoma subtype gene signatures were tested by using each signature as a reference and comparing it to the gene expression for all 23 lymphoma samples. For each sample, points were assigned for every gene that matched the reference signature, then totaled and expressed as a percentage of the total number of genes for that signature. The results of this test confirmed that the signatures were effective in classifying lymphoma subtypes. For example, the four FL samples matched the expression of the 70 genes in the FL signature for an average of 97.5%. The next closest sample, DLBCL-5, registered an 88.5% match, with most other samples showing much lower correlations. The results of this testing procedure are shown in Table 44 below.

An example of partial raw test data for HL signature genes in shown below in Table 45. Some columns were removed in order to fit onto page; this table is meant to explain how percentage scores were reached, rather than show complete data. Score columns were added for each sample, and the total score was divided by the number of genes in the signature (33 in the case of HL) to arrive at a percentage match value.

Summary of test results for subtype signatures (percentage match values for all signatures and samples) Samples DLBCL-1 DLBCL-2 DLBCL-3 DLBCL-4 DLBCL-5 FL-1 FL-3 FL-4 FL-5 HL-1 HL-2 HL-3 HL-4 Signatures DLBCL 98.04 90.20 98.04 92.16 94.12 72.55 54.90 50.98 52.94 50.98 50.98 50.98 33.33 FL 68.57 54.29 61.43 41.43 88.57 94.29 98.57 98.57 98.57 41.43 62.86 42.86 55.71 HL 42.42 69.70 72.73 75.76 78.79 69.70 72.73 69.70 66.67 100.00 100.00 100.00 90.91 MCL 51.25 36.25 53.75 33.75 60.00 56.25 58.75 66.25 50.00 25.00 38.75 22.50 55.00 MZL 71.07 63.52 69.81 32.70 64.15 77.36 46.54 62.26 49.69 51.57 41.51 46.54 37.74 SLL 64.06 53.91 59.38 31.25 66.41 68.75 49.22 65.63 50.00 40.63 39.06 38.28 39.06 TCL 60.87 71.74 70.65 44.57 52.17 58.70 27.17 35.87 38.04 68.48 38.04 69.57 16.30 Samples MCL-1 MCL-2 MCL-3 MCL-4 MZL-2 MZL-4 SLL-1 SLL-3 TCL-1 TCL-2 Signatures DLBCL 58.82 62.75 54.90 31.37 58.82 58.82 50.98 52.94 60.78 54.90 FL 67.14 71.43 68.57 47.14 75.71 78.57 61.43 71.43 45.71 38.57 HL 54.55 63.64 48.48 51.52 57.58 66.67 54.55 45.45 72.73 57.58 MCL 91.25 97.50 97.50 92.50 76.25 78.75 81.25 78.75 21.25 37.50 MZL 84.28 74.84 63.52 40.88 100.00 100.00 78.62 73.58 57.23 39.62 SLL 84.38 76.56 74.22 48.44 82.03 86.72 100.00 98.44 47.66 43.75 TCL 53.26 50.00 39.13 17.39 51.09 51.09 42.39 47.83 100.00 98.91

TABLE 45 Raw test data for HL signature genes Reference HL DLBCL-1 DLBCL-2 FL-4 FL-5 HL-1 HL-2 HL-3 HL-4 Genes vsZ vsZ Score vsZ Score vsZ Score vsZ Score vsZ Score vsZ Score vsZ Score vsZ Score CCL19 up up 1 up 1 up 1 up 1 up 1 up 1 up 1 up 1 CYP27B1 up up 1 up 1 null 0 up 1 up 1 up 1 up 1 up 1 PISD down null 0 null 0 null 0 null 0 down 1 down 1 down 1 null 0 DHCR24 up up 1 up 1 up 1 null 0 up 1 up 1 up 1 up 1 LGMN up null 0 null 0 up 1 up 1 up 1 up 1 up 1 up 1 TGFBR3 down down 1 down 1 down 1 down 1 down 1 down 1 down 1 down 1 EBI2 down down 1 down 1 null 0 null 0 down 1 down 1 down 1 null 0 TFF3 up null 0 up 1 up 1 null 0 up 1 up 1 up 1 up 1 MMP12 up up 1 up 1 null 0 null 0 up 1 up 1 up 1 up 1 LYN down down 1 down 1 down 1 down 1 down 1 down 1 down 1 null 0 IL1R1 up null 0 up 1 up 1 up 1 up 1 up 1 up 1 up 1 CD81 up null 0 null 0 up 1 up 1 up 1 up 1 up 1 up 1 APOC2 up null 0 up 1 null 0 up 1 up 1 up 1 up 1 up 1 TRAF1 up up 1 up 1 up 1 up 1 up 1 up 1 up 1 up 1 SLAMF1 up down 0 up 1 up 1 up 1 up 1 up 1 up 1 up 1 CDKN2D down null 0 down 1 down 1 down 1 down 1 down 1 down 1 down 1 PRAME up up 1 null 0 null 0 null 0 up 1 up 1 up 1 up 1 SORL1 down null 0 down 1 null 0 null 0 down 1 down 1 down 1 down 1 CSTA down down 1 null 0 down 1 null 0 down 1 down 1 down 1 down 1 HSPA6 down null 0 down 1 down 1 down 1 down 1 down 1 down 1 down 1 GSTT1 up null 0 up 1 up 1 null 0 up 1 up 1 up 1 up 1 PIK3C2B up up 1 null 0 up 1 up 1 up 1 up 1 up 1 up 1 KIAA0992 up null 0 null 0 null 0 null 0 up 1 up 1 up 1 up 1 GNG11 down down 1 down 1 null 0 down 1 down 1 down 1 down 1 down 1 13CDNA73 down down 1 down 1 down 1 down 1 down 1 down 1 down 1 down 1 CTLA4 up null 0 up 1 up 1 up 1 up 1 up 1 up 1 up 1 MRPL33 down down 1 down 1 down 1 down 1 down 1 down 1 down 1 down 1 STAT1 up down 0 null 0 null 0 up 1 up 1 up 1 up 1 up 1 FLJ40504 up down 0 up 1 up 1 null 0 up 1 up 1 up 1 up 1 AKR1C1 up null 0 null 0 up 1 up 1 up 1 up 1 up 1 up 1 KLRK1 down null 0 down 1 down 1 down 1 down 1 down 1 down 1 down 1 NFKBIA up null 0 null 0 up 1 up 1 up 1 up 1 up 1 up 1 STS-1 down null 0 down 1 down 1 down 1 down 1 down 1 down 1 down 1 42.4 69.7 69.7 66.7 100 100 100 90.9

Numerous genes on the HCP array found to be differentially expressed in certain subtypes are consistent with recent publications. For example, Rosenwald et al. showed that both BANK1 and SPAP1 were overexpressed in MCL, in agreement with the hematological cancer profiling signatures as shown in Table 35. As well, several of the DLBCL signature genes identified using the HCP array, namely the overexpression of NME1, MCM7 and BIK, have been confirmed by multiple sources.

Example 20 Analysis of Data Generated from Hybridization of Leukemia Test Samples to HCP Array

The gene expression profiles resulting from the hybridization of test sample cRNA with the HCP array were analyzed using microarray analysis software to identify differentially expressed genes and establish distinct genetic profiles for lymphoma subtypes. Clustering algorithms were also employed.

Lymphoma and leukemia experiments were performed at different times and, therefore, were analyzed separately. The data analysis methods varied for the two data sets due to the differing sample sizes and subtype representation of the lymphoma and leukemia studies.

Before performing analyses, expression values were normalized using the quantile normalization method so that the gene expression between samples could be compared. Technical replicates were merged by taking the average of expression values.

Leukemia Data Analysis

SAM analysis was performed to identify genes with significant differential expression. From the resulting set of genes, a one-way ANOVA, with Stepdown Westfall-Young adjustment to p-values, was used to select genes with p<0.01. These analyses yielded a list of 157 genes that were differentially expressed between leukemia subtypes.

The 157 genes found to be differentially expressed were clustered using hierarchical clustering with average linkage using the Euclidian distance metrics, shown in FIG. 9. A list of these genes is found in Table 3 above. Differential gene expression is seen between leukemia and controls as well as between the various leukemia subtypes.

To determine the unique gene signatures for each leukemia subtype, a 5 fold filter was imposed on the 157 significant genes. Only genes that showed a fold change of greater than 5 or less than −5 in a subtype were considered to be “signature” genes. Gene lists for CLL, AML and T-ALL were each filtered to meet these criteria, thereby producing subtype-specific gene signatures. Signature genes for individual leukemia subtypes are listed in Tables 39-41 and shown as hierarchical clustering images in FIGS. 10-12.

Results

The HCP array was able to detect genes in the leukemia and control samples. Correlation coefficient and other statistical analyses revealed that sample replicates were highly similar to one another, demonstrating the consistency of the HCP array. Statistical analyses also revealed a high dissimilarity between the lymphoma and leukemia subtypes and controls, indicating that the HCP array is able to detect differential expression profiles (see FIG. 9). As well as distinguishing between “diseased” and “healthy” samples, the HCP array identified distinct gene expression profiles that were produced by the different leukemia subtypes. These profiles, seen in FIGS. 9-12, provide information useful for accurate diagnosis and risk assessment.

The HCP array identified unique gene expression profiles, referred to as signatures, for each of the leukemia subtypes tested. The following genetic signatures distinguished specific leukemia subtypes, and are listed in relation to the expression level in control samples.

Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia (CLL) is the most common adult leukemia. CLL is a cancer of the B- or T-lymphocytes; B-CLL is the prevalent form of CLL, T-lymphocyte abnormalities, while more severe, account for less than 5% of CLL cases. CLL can be difficult to diagnose, due to its slow onset and vague symptoms. The Flu-like nature of some of the common CLL symptoms, such as fever and fatigue, are often a cause of delayed or misdiagnosis.

CLL has become a topic of particular interest to physicians due to its inconsistent response to treatment. Many CLL patients respond well to chemotherapy and/or radiation, while others show virtually no improvement. Recent research by Mackey et al. Blood 2005 Jan. 15; 105(2): 767-774, and Vallat et al. Blood 2003 Jun. 1; 101(11): 4598-4606, has suggested the existence of distinct CLL subtypes that are resistant to chemotherapy and radiation treatment, respectively. Identification of new CLL subtypes is the next step in understanding and improving the prognosis of CLL. CLL signature genes are shown in Table 39.

Acute Myelogenous Leukemia

Acute Myelogenous Leukemia (AML) patients worsen quickly, making fast and accurate diagnosis a must. Unfortunately, AML can easily be misdiagnosed using common (aforementioned) methods. Most AML patients respond well to initial treatment, however, AML has a high rate of relapse. Improved understanding of gene expression within AML will lead to efficient diagnostic tools as well as outcome prediction. AML signature genes are shown in Table 40.

Acute T-Cell Lymphocytic Leukemia

Acute T-Cell Lymphocytic Leukemia (T-ALL) is the most common leukemia among children and adolescents. Less understood than its B-Cell counterpart, T-ALL proves difficult to classify. T-ALL does not display distinct subtypes, making risk assessment challenging. However, a recent study by Chiaretti et al. Blood 2004 Apr. 1; 103(7): 2771-2778, showed that gene expression profiles can provide insight into prognosis of T-ALL, with certain genes indicating a favorable outcome and others a high risk of relapse. T-ALL signature genes are shown in Table 41.

The results of this study indicate that the above gene signatures can be used to distinguish between leukemia subtypes thereby facilitating accurate diagnosis and timely treatment for patients.

The disclosure of all patents, publications, including published patent applications, and database entries referenced in this specification are specifically incorporated by reference in their entirety to the same extent as if each such individual patent, publication, and database entry were specifically and individually indicated to be incorporated by reference.

Although the invention has been described with reference to certain specific embodiments, various modifications thereof will be apparent to those skilled in the art without departing from the spirit and scope of the invention as outlined in the claims appended hereto. 

1. A system for profiling a hematological cancer comprising at least ten polynucleotide probes, each of said probes being between about 15 and about 500 nucleotides in length and comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene selected from the group of genes set forth in Table 1, wherein the level of expression of said gene is indicative of one or more features of said hematological cancer.
 2. The system according to claim 1, wherein said one or more features are selected from the group of: presence, absence, type, subtype, stage, progression, grade, aggressivity, outcome, survival and drug-responsiveness.
 3. The system according to claim 1, wherein each of said probes comprises a sequence corresponding to, or complementary to, an mRNA transcribed from a gene selected from the group of genes set forth in Tables 2-19.
 4. The system according to claim 1, wherein said at least ten polynucleotide probes are selected from: (a) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 2; (b) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 3; (c) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 4; (d) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 5; (e) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 6; (f) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 7; (g) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 8; (h) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 9; (i) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 10; (j) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 11; (k) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 12; (l) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 13; (m) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 14; (n) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 15; (o) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 16; (p) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 17; (q) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 18, and (r) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table
 19. 5. The system according to claim 1, wherein each of said probes comprises at least 15 nucleotides of a sequence as set forth in any one of SEQ ID NOs: 1-4530.
 6. The system according to claim 1, wherein each of said probes comprises a sequence as set forth in any one of SEQ ID NOs: 1-4530.
 7. The system according to claim 1, wherein said system comprises at least 50 polynucleotide probes.
 8. The system according to claim 1, wherein said system comprises at least 100 polynucleotide probes.
 9. The system according to claim 1, wherein said hematological cancer is selected from the group of lymphoma and leukemia.
 10. The system according to claim 1, wherein said hematological cancer is a lymphoma selected from the group of: B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), B-cell prolymphocytic leukemia, lymphoplamacytic lymphoma, splenic marginal zone B-cell lymphoma, nodal marginal zone B-cell lymphoma, hairy cell leukemia, plasma cell myeloma/plasmacytoma, follicular lymphoma (FL), mantle cell lymphoma (MCL), Burkitt's lymphoma, diffuse large cell B-cell lymphoma (DLBCL) Hodgkin's lymphoma, lymphoblastic lymphoma, anaplastic large cell lymphoma (ALCL), cutaneous T-cell lymphoma, mycosis fungoids/Sézary's syndrome, peripheral T-cell lymphomas, angioimmunoblastic lymphoma, angiocentric lymphoma (nasal T-cell lymphoma), intestinal T-cell lymphoma, and adult T-cell lymphoma/leukemia.
 11. The system according to claim 1, wherein said hematological cancer is a leukemia selected from the group of: acute myelogenous leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, and chronic lymphocytic leukemia.
 12. Use of the system according to claim 1, for the preparation of a nucleic acid array.
 13. A method of profiling a hematological cancer in a subject comprising: (a) providing one or more gene sets, each gene set comprising at least five genes selected from the genes set forth in Table 1, wherein the expression level of each gene in said one or more gene sets is indicative of a feature of a hematological cancer; (b) determining the expression level of each gene in said one or more gene sets in a test sample obtained from said subject to provide an expression pattern profile, and (c) comparing said expression pattern profile with a reference expression pattern profile.
 14. The method according to claim 13, wherein said feature is selected from the group of: presence, absence, type, subtype, stage, progression, grade, aggressivity, outcome, survival and drug-responsiveness.
 15. The method according to claim 13, wherein the expression level of each gene is determined in step (b) by contacting the test sample with a plurality of polynucleotide probes, each of said probes being between about 15 and about 500 nucleotides in length and comprising a sequence corresponding to, or complementary to, a gene from said one or more gene sets.
 16. The method according to claim 15, wherein each of said probes comprises at least 15 nucleotides of a sequence as set forth in any one of SEQ ID NOs: 1-4530.
 17. The method according to claim 13, wherein said hematological cancer is selected from the group of lymphoma and leukemia.
 18. The method according to claim 13, wherein said hematological cancer is a lymphoma selected from the group of: B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), B-cell prolymphocytic leukemia, lymphoplamacytic lymphoma, splenic marginal zone B-cell lymphoma, nodal marginal zone B-cell lymphoma, hairy cell leukemia, plasma cell myeloma/plasmacytoma, follicular lymphoma (FL), mantle cell lymphoma (MCL), Burkitt's lymphoma, diffuse large cell B-cell lymphoma (DLBCL) Hodgkin's lymphoma, lymphoblastic lymphoma, anaplastic large cell lymphoma (ALCL), cutaneous T-cell lymphoma, mycosis fungoids/Sézary's syndrome, peripheral T-cell lymphomas, angioimmunoblastic lymphoma, angiocentric lymphoma (nasal T-cell lymphoma), intestinal T-cell lymphoma, and adult T-cell lymphoma/leukemia.
 19. The method according to claim 13, wherein said hematological cancer is a leukemia selected from the group of: acute myelogenous leukemia, acute lymphocytic leukemia, chronic myelogenous leukemia, and chronic lymphocytic leukemia.
 20. The method according to claim 13, wherein each of said gene sets comprises at least ten genes and said one or more gene sets are selected from the group of: (a) a gene set comprising at least ten genes selected from the genes set forth in Table 32; (b) a gene set comprising at least ten genes selected from the genes set forth in Table 33; (c) a gene set comprising at least ten genes selected from the genes set forth in Table 34; (d) a gene set comprising at least ten genes selected from the genes set forth in Table 35; (e) a gene set comprising at least ten genes selected from the genes set forth in Table 36; (f) a gene set comprising at least ten genes selected from the genes set forth in Table 37; (g) a gene set comprising at least ten genes selected from the genes set forth in Table 38; (h) a gene set comprising at least ten genes selected from the genes set forth in Table 39; (i) a gene set comprising at least ten genes selected from the genes set forth in Table 40, and (j) a gene set comprising at least ten genes selected from the genes set forth in Table
 41. 21. A nucleic acid array comprising at least ten polynucleotide probes immobilized on a solid support, each of said probes being between about 15 and about 500 nucleotides in length and comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene selected from the group of genes set forth in Table 1, wherein the level of expression of said gene is indicative of one or more features of said hematological cancer.
 22. The nucleic acid array according to claim 21, wherein said one or more features are selected from the group of: presence, absence, type, subtype, stage, progression, grade, aggressivity, outcome, survival and drug-responsiveness.
 23. The nucleic acid array according to claim 21, wherein each of said probes comprises at least 15 nucleotides of a sequence as set forth in any one of SEQ ID NOs: 1-4530.
 24. The nucleic acid array according to claim 21, wherein each of said probes comprises a sequence as set forth in any one of SEQ ID NOs: 1-4530.
 25. The nucleic acid array according to claim 21, wherein each of said probes comprises a sequence as set forth in any one of SEQ ID NOs: 1-1153.
 26. The nucleic acid array according to claim 21, wherein each of said probes comprises a sequence as set forth in any one of SEQ ID NOs: 1154-2299.
 27. The nucleic acid array according to claim 21, wherein each of said probes comprises a sequence as set forth in any one of SEQ ID NOs: 2300-3426.
 28. The nucleic acid array according to claim 21, wherein each of said probes comprises a sequence as set forth in any one of SEQ ID NOs: 3427-4530.
 29. The nucleic acid array according to claim 21, wherein said nucleic acid array comprises at least 50 polynucleotide probes.
 30. The nucleic acid array according to claim 21, wherein said nucleic acid array comprises at least 100 polynucleotide probes.
 31. The nucleic acid array according to claim 21, wherein each of said probes comprises a sequence corresponding to, or complementary to, an mRNA transcribed from a gene selected from the group of genes set forth in Table
 2. 32. The nucleic acid array according to claim 21, wherein each of said probes comprises a sequence corresponding to, or complementary to, an mRNA transcribed from a gene selected from the group of genes set forth in Table
 3. 33. The nucleic acid array according to claim 21, wherein said at least ten polynucleotide probes are selected from: (a) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 32; (b) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 33; (c) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 34; (d) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 35; (e) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 36; (f) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 37; (g) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 38; (h) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 39; (i) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table 40, and (j) at least ten polynucleotide probes comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene from a set of genes comprising one or more genes as set forth in Table
 41. 34. The nucleic acid array according to claim 21, further comprising one or more control probes.
 35. A polynucleotide probe between about 15 and about 500 nucleotides in length and comprising a sequence corresponding to, or complementary to, an mRNA transcribed from a gene selected from the group of genes set forth in Table 1, wherein said probe comprises at least 15 consecutive nucleotides of a sequence as set forth in any one of SEQ ID NOs: 1-4530.
 36. The polynucleotide probe according to claim 35, wherein said polynucleotide probe comprises a sequence as set forth in as set forth in SEQ ID NOs: 1-4530.
 37. The polynucleotide probe according to claim 35, wherein said polynucleotide probe consists of a sequence as set forth in any one of SEQ ID NOs: 1-4530.
 38. A set of genes having an expression pattern representative of one or more features of a hematological cancer and comprising at least ten genes selected from: (a) at least ten genes selected from the genes set forth in Table 32; (b) at least ten genes selected from the genes set forth in Table 33; (c) at least ten genes selected from the genes set forth in Table 34; (d) at least ten genes selected from the genes set forth in Table 35; (e) at least ten genes selected from the genes set forth in Table 36; (f) at least ten genes selected from the genes set forth in Table 37; (g) at least ten genes selected from the genes set forth in Table 38; (h) at least ten genes selected from the genes set forth in Table 39; (i) at least ten genes selected from the genes set forth in Table 40, and (j) at least ten genes selected from the genes set forth in Table
 41. 39. The set of genes according to claim 38, wherein said one or more features are selected from the group of: presence, absence, type, subtype, stage, progression, grade, aggressivity, outcome, survival and drug-responsiveness.
 40. The set of genes according to claim 38, wherein said hematological cancer is a lymphoma and said at least ten genes are selected from: (a) at least ten genes selected from the genes set forth in Table 32; (b) at least ten genes selected from the genes set forth in Table 33; (c) at least ten genes selected from the genes set forth in Table 34; (d) at least ten genes selected from the genes set forth in Table 35; (e) at least ten genes selected from the genes set forth in Table 36; (f) at least ten genes selected from the genes set forth in Table 37; and (g) at least ten genes selected from the genes set forth in Table
 38. 41. The set of genes according to claim 38, wherein said hematological cancer is a leukemia and said at least ten genes are selected from: (a) at least ten genes selected from the genes set forth in Table 39; (b) at least ten genes selected from the genes set forth in Table 40, and (c) at least ten genes selected from the genes set forth in Table
 41. 42. A library of genes for profiling a hematological cancer, comprising the genes as set forth in Table
 1. 43. A computer-readable medium comprising one or more digitally-encoded expression pattern profiles representative of the set of genes according to claim 38, each of said one or more expression pattern profiles being associated with one or more values wherein each of said one or more values is correlated with one of said one or more features of a hematological cancer. 